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Query: VFG002420(gi:21281752) (adsA) Adenosine synthase A [AdsA (VF0422)] [Streptococcus pyogenes MGAS315], from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKALLLKTSVWLVLLFSVMGLWQVSNAAEQHTPMKAHAVTTIDKATTDRQQVPPTKEAAHHYGEEAATNVSASAQGTADDTNNKVTSNAPTNKPTTAVSTTGNKRHDVDAQQASTQKPTHTATFKLSNAKTASLSPRMFAANVPQTTTHKILHTNDIHGRLAEEKGRVIGMAKLKTVKEQEKPDLMLDAGDAFQGLPLSNQSKGEEMAKAMNAVGYDAMAVGNHEFDFGYDQLKKLEGMLDFPMLSTNVYKDGKRAFKPSTIVTKNGIRYGIIGVTTPETKTKTRPEGIKGVEFRDPLQSVTAEMMRIYKDVDTFVVISHLGIDPSTQETWRGDYLVKQLSQNPQLKKRITVIDGHSHTVLQNGQIYNNDALVQTGTALANIGKITFNYRNGEVSNIKPSLINVKDVENVTPNKALAEQINQADQTFRAQTAEVIIPNNTIDFKGERDDVRTRETNLGNAIADAMEAYGVKNFSKKTDFAVTNGGGIRASIAKGKVTRYDLISVLPFGNTIAQIDVKGSDVWTAFEHSLGAPTTQKDGKTVLTANGGLLHISDSIRVYYDMNKPSGKRINAIQILNKETGKFESIDLKRVYHVTMNDFTASGGDGYSMFGGPREEGISLDQVLASYLKTANLAKYDMTEPQRMLLGKPVASEQPAKGQQGSKGSESGKDTQPIGKEKVMNPAKQPATGKVVLLPAHRGTVSSGTEGSDRALEGTAVSSKSGKQLANMSAPKGSAHEKQLPKTGTDQSSSPAAMFVLVTGIGLIATVRRRKASLast
1 -160.000 VFG002420(gi:21281752) (adsA) Adenosine synthase A [AdsA (VF0422)] [Streptococcus pyogenes MGAS315]  ali  100  1MKALLLKTSVWLVLLFSVMGLWQVSNAAEQHTPMKAHAVTTIDKATTDRQQVPPTKEAAHHYGEEAATNVSASAQGTADDTNNKVTSNAPTNKPTTAVSTTGNKRHDVDAQQASTQKPTHTATFKLSNAKTASLSPRMFAANVPQTTTHKILHTNDIHGRLAEEKGRVIGMAKLKTVKEQEKPDLMLDAGDAFQGLPLSNQSKGEEMAKAMNAVGYDAMAVGNHEFDFGYDQLKKLEGMLDFPMLSTNVYKDGKRAFKPSTIVTKNGIRYGIIGVTTPETKTKTRPEGIKGVEFRDPLQSVTAEMMRIYKDVDTFVVISHLGIDPSTQETWRGDYLVKQLSQNPQLKKRITVIDGHSHTVLQNGQIYNNDALVQTGTALANIGKITFNYRNGEVSNIKPSLINVKDVENVTPNKALAEQINQADQTFRAQTAEVIIPNNTIDFKGERDDVRTRETNLGNAIADAMEAYGVKNFSKKTDFAVTNGGGIRASIAKGKVTRYDLISVLPFGNTIAQIDVKGSDVWTAFEHSLGAPTTQKDGKTVLTANGGLLHISDSIRVYYDMNKPSGKRINAIQILNKETGKFESIDLKRVYHVTMNDFTASGGDGYSMFGGPREEGISLDQVLASYLKTANLAKYDMTEPQRMLLGKPVASEQPAKGQQGSKGSESGKDTQPIGKEKVMNPAKQPATGKVVLLPAHRGTVSSGTEGSDRALEGTAVSSKSGKQLANMSAPKGSAHEKQLPKTGTDQSSSPAAMFVLVTGIGLIATVRRRKAS 772
2 -15.100 VFG000680(gi:6470207) (capA) CapA, required for Poly-gamma-glutamate transport [Capsule (VF0141)] [Bacillus anthracis]  ali follow..  16  33.........................................................................................................................IAVILIAATWVQRTEAVAPVKHRENEKLTMTMVGDI-GRHVKEIVNRYGTDYVFRHVSP-----YLKNSDYVSGNFEHPVLLEDETVKAVKEAGFTVLNLANHMTDYGAKGTKDAFKEADLDYVGAGENFKDV---KNIVYQNVNGVRVATLGFTDAFVAGAIATKEQPGSLSMNPLKQISKAKDPKKGNADLVVVNTHWGEEYDNKPSPRQEALAKAMVDA----GADIIVGHHPH-VLQSFDVYKQGIIFYS------LG--NFVFDQGWTRTKDSALVQYHLRDNGTAILDVV................................................................................................................................................................................................................................................................................................................................................................... 332
3 -8.950 VFG045588(gi:52842794) (legS1) Dot/Icm type IV secretion system effector LegS1 [Dot/Icm (VF0156)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]  ali follow..  11  1...............................................................................................................................MNFSIRVILLLTGFVSLAFSAPKFLTISDIHAKDGQDTGKEFLDVTFKRFEELSQNDFILHLGDLPTHSLFSIPKKEEYEQVVFHGL-----ITGNNDSPLNLALDWDGACAYCDGLIIDDTHMRKDGYYSSYVIPNNKEIIL--IALNSVQWTKTPVFLPKYPNQQRDAFVQLFWLEQQLKNRAKQLLLAMHVGTAYNGNRFWHDIYLDRFLTLLDKYHQSYDQITSHSHM--------EEFRKIRLSD-----GSTIYAFSTPGISRAHHN-----KIFDLDKQMRVRNSTTYYTSDLYEWGNEYYQAMNTPDAIFPNCQNKTIPQCLDTLSPE..................................................................................................................................................................................................................................................................................................................... 354
4 -8.630 VFG000106(gi:15640862) (acfD) accessory colonization factor AcfD [ACF (VF0127)] [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  10  1MKIRIVSLIVLGFLLDGNLKFDSSLLCNDQDASHFQISQKDNVFCTINGRSIAT----TAPFDANKNGRNTDSEVLSLISADEYRDSPVRQENLQILMKNMATIHGDKISLVFRSTLDALTFENYLRHNLDLPKDQFLEAITEKIANDNQV-HVPNISPSFTPGTSSNLNSPFVSANAEESSLGRLLDSGRVINGVSYFSNTRGITGVDKTGA----ILNDGSFEFSWG-DIISFSIDTFELGSTRAN-----KTDFYISELGK-DNEGKNAEALIHRYASIDDS-----KLIIPDKVTQI------FSLYPNVINEVISLSLPNGDIELDIGD-------------GKTQIVPGEFFKQFDSGALIDQSISPISRFKFEDSLPKKK-----SAIDSESSQIQDIINKLWGATDTVQANVDRFH-----------IFHDSTNFYGSTGSARAQAANIANSAFPVLMARNDNNY--GKPKAWDSNS-VSEDISLGEIGKGKLVLVCPWGGTVKNGTCSRDDMANFFSNVIRYLTGSTSNDVIVGTN-KSSGQTMGSKANFELDSRFSKQTQQLT-------SFHDLDVNTIPLIIINAYGKNINSPYPLSADVGSPKLSRSDVLIDYINNGGSV........................................................................................................................................... 697
5 -8.550 VFG013321(gi:16272676) (lpxH) UDP-2,3-diacylglucosamine pyrophosphohydrolase [LOS (CVF494)] [Haemophilus influenzae Rd KW20]  ali follow..  14  3.....................................................................................................................................................HSYFISDLHLSETQPELTALFVDFMQNLAPQAERLYIL--GDLFDGDDEQSALIQQDLIKFVSDQGVQCYFQGNRDFLIGERFSKE----------------TGAQLLPDYQLITLYDKKILLC-LCIDDEAYQQFRRRVHQLFLCLPLKVRVIIAEKIRAKSNQ---------DKQAKSQEIMDVNQAFTAEKVQEFGVNLLIHGHTHREAIHQQEEFTRIVL--GDWRKNYASILKMDESGEFGFIK...................................................................................................................................................................................................................................................................................................................................................................................... 236
6 -7.880 VFG043508(gi:29374740) (fss1) Enterococcus faecalis surface protein Fss1, fibrinogen binding protein [Fibrinogen binding protein (AI271)] [Enterococcus faecalis V583]  ali follow..  11 1202...................................................................................................................................................LYQFTEIEAPTGYLLDTTNTSGQIRDVHVKMLNYQGSAELQAGNPLAGAEFS--TTGQAVREHLGKVTVTDLAPGKYQ-------FVETKAPAGYLLSAFTIAASDRGKPATVIATANFVNYQGTAKLIKKD----VNGHLLSGATFKVLDAKGETIQTGLTTNNQGEIVAEHLGYLLNTTPYKGAFQIVKTNSADQPLAGAVFELYDHNKQSLGITATSGKD------------GKIIFR----DLAPGTYYYKEIKAPKLPDGADYIIYPELVKVEIRGDFKGDPEIFQLGAFANFKGRAVFKKIDANANPLPGTLYRIENGEKIFEREVTAEKDGSLAEDLGAGSYELDELDATDGYGAVFAIYNADEQNQPQGSPITFLNRAGEKVSEITTDKTG-AKGLNEGHYVLVETKAPTGYLLDTTAQLTKENETGEALA-GAVFKVIDET-LMSDKQGYRFVETQAPTSYLLNETPSASFTIAKDNQGKPATGAAKLVKIDQQKNALAGAEFKVTDAETGQTVARSVETKAPDGYQLSKQAVAFTIAATAKDKPELVNAGTFVNEKQPVSKKTKPNQPTTKQAARETGWLGLPKTNTQVNYFFVFIGLMLVGLASWLFYKKSKK. 1987
7 -7.330 VFG045343(gi:218928804) (yapJ) autotransporter protein YapJ [YapJ (VF0509)] [Yersinia pestis CO92]  ali follow..  10  748................................................................................ATVNRLSAADIAADPTLVATETGALTLAEGGALSSLGDSVLSGNLISAGGILLSNHYTGGNGAATDDRLTV--ENNGSGE--------GAWLALDTVLDDSATDRLVINGDA----------TGTTSVRVNNAGGLGDKTLG-------------------INLITVDGLAQDDTFLLAGDYVTTDGYQAVVGGLQADGEAATAGRNYLSSELMLTEGVRYQAGVPLYEQYPQVLAALNTLPTLQQRVGNRYGAPGALADLDFDNNQWA--IEGSHQVTDPARSTSGSQ---REIDVWKLQTG---------------IDVPLYQSQDGSLLTGGVNFSYGKAKADIHSF-----FGDGRINSAG----------GLGGVYVDGQLQTMWFDSDLSSRTA-NNGRGYTSAIEAGGYALGNGLSLTPQMQVTTFRDPFDSEVSDSLRGRIGVSLDKETTWSAKDGTTRRSHIYSHLDLHNEFLNGSKVQVSGVEFATRDERQSVGLGAGGTYEWQNGRYAVYGNVNLLGATRNVSDNYAVGGTI..................................................................................................................................................... 1262
8 -7.210 VFG045344(gi:22127304) (yapV) autotransporter protein YapV [YapV (VF0507)] [Yersinia pestis KIM 10]  ali follow..  10  726......................................................................NATLGLTPATTILNRLSAADIAADPTLVATETGALTLAEGGALSSLGDSVLSGNLISAGGILLSNTYTGGNGAATDDRLTV--ENNGSGE--------GAWLALDTVLDSATDRLVIN-GDA----------TGTTSVRVNNAGGLGDKTLG-------------------INLITVDGLAQDDTFLLAGDYVTTDGYQAVVAGLQADGEAATAGRNYLSSELMLTEGVRYQVGVPLYEQYPQVLAALNTLPTLQQRVGNRYGAPGALADLNFDDNQWA--IEGSHQVTDPARSTSGSQR---EIDVWKLQTG---------------IDVPLYQSQGGSLLTGGVNFTYGKAKADIHSF-----FGDGRINSAG----------GLGGVYVDGQLQTMWFDSDLSSRTA-NNGRGYTSAIEAGGYALGNGLSLTPQMQVTTFRDPFDSEVSDSLRGRLGVSLDKETTWSAKDGTTRRSHIYSHLDLHNEFLNGSKVQVSGVEFATRDERQSVGLGAGGTYEWQNGRYAVYGNVNLLGATRNVSDNYAVGGTI..................................................................................................................................................... 1250
9 -6.990 VFG001210(gi:15599750) (pilY1) type 4 fimbrial biogenesis protein PilY1 [Type IV pili (VF0082)] [Pseudomonas aeruginosa PAO1]  ali follow..  11  476.......DQLVAAFQDILNRISGKDLPASRPAISSSLQEDDTGDKLTRFAYQTSFASDKNWAGDLTRYSLTTQDKATVQTKLWSAQSILDAMPNGGA----GRKIMMAGSGTSGLKEFTWGSLSADQQRQLNRDPDRNDVADTKGQDRVAFLRGDRRKEN-------------------RTRNSIL---GDIINSSPATAQYLTYLAQPIEPSGNYSTVYVGNHGFDTDGNETFAFIPSAVFEKLHKQFYVDGSPVVADAFFLRAGGKGLFALDVTDPANIKLVDQEPDLGYSFPKPT------VARLHNGKWAVVT----GYSSLND---KAALLIIDLETGAITRKLEVTGRTGVPNGLSSPRLANSDGVADYAYAGDLQGNLRFDLIAGKVNQDDPFSRANDGPAVASSFRVSFGGQPLYSAVDSAGAAQAITAAPSLVRHPTRKGYIV---GTGKYFENA--DARADTSRAQTLYGIWDQQTKGEAASTPRLTRGNLQQQTLDLQADSTFASTARTIRIASQNPVNWLNNDGST----KQSGWYLDFMVN-------GTLKGEMLIEDMIAIGQVVLLQTI-------TPNDDPCADGASNWTYGLDPYTGGRTSFTVF..................................................................................................................................................... 1087
10 -6.960 VFG002173(gi:29377844) (asa1) aggregation substance Asa1 [AS (VF0352)] [Enterococcus faecalis V583]  ali follow..  920......................................................................................................................................................................................................................................................................................................................................................GEDINHGKVARGD-SYEMTWDLKGYDKDFAFDTVDLATGVSFFDVTPIKDLLRVKDSKGEDITNQFTISWDDAKGTVTQAFILAHGGQELRVTLPTKVKANVSGDVYNLAEQNTFGQRIKTNTVVNHIPKVNPKKDVVIKVGDK--QSQNGATIKLGEKFF----------YEFTSSDIPAEYAGIVEEWSISDKLDVKHDKSGQWSVFANTFVLADGTKVNKGDDISKLFTMTFEQGVVK-ITASQAFLLKENKNVAHSWKAFIGVERIAA---DVYNTIEESFNNE------KIKTNTVVTHTPEKPQTPPEKTVIVPPTPKTPQAPVEPLVVEKAS-----------------------------------------------------VVPELPQTGEKQNVLLTVAGSLAAMLGLAGLGFKRRKE 1294

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;