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Query: gi|6319260|ref|NP_009343.1|(removed signalp:1-19) Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast; Cne1p (YAL058W) [Saccharomyces cerevisiae], from S.cerevisiae

Results of FFAS03 search in COG0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst TSLLSNVTLAEDSFWEHFQAYTNTKHLNQEWITSEAVNNEGSKIYGAQWRLSQGRLQGSAWDKGIAVRTGNAAAMIGHLLETPINVSETDTLVVQYEIKLDNSLTCGGAFIKLMSGFMNVEALKHYAPDTEGVELVFGPDYCAPEINGVQFAINKVDKITHESKLRYLQEMPLSKLTDTSQSHLYTLIIDESAQSFQILIDGKTVMVREHIEDKKKVNFEPPITPPLMIPDVSVAKPHDWDDRIRIPDPEAVKLSDRDERDPLMIPHPDGTEPPEWNSSIPEYILDPNAQKPSWWKELEHGEWIPPMIKNPLCTAERGCGQQIPGLINNAKYKGPGELNEIINPNYMGEWHPPEIENPLYYEEQHPLRIENVISGVILEFWSGSPNMLISNIYVGKNVTEAQIIGNKTWLMRDRAFRGSDGPTERKFMNSRLGNLQTTFHNERESPNPFDRIIDRILEQPLKFVLTAAVVLLTTSVLCCVVFTLast
1 -111.000[O] KOG0675 Calnexin  ali follow..  27  49IKYKTPQPIGEVYFAETFD-----SGRLAGWVLSKAKKDDEISIYDGRWEIEELKENQVPGDRGLVLKSRAKHHAISAVLAKPF-IFADKPLIVQYEVNFQDGIDCGGAYIKLLADTDDLI--LENFYDKTSYIIMFGPDKCGE-DYKLHFIFRHKHPKTGVFEEKHAKPPDVKKFFTDRKTHLYTLVMNP-DDTFEVLVDQTVVNKGSLLED-----VVPPIKPPKEIEDPNDKKPEEWDERAKIPDPSAVKPEDWDESEPAQIEDSSVVKPAGWLDDEPKFIPDPNAEKPDDWNEDTDGEWEAPQILNPACR--IGCGEWKPPMIDNPKYKGVWRPPLVDNPNYQGIWSPRKIPNPDYFEDDHPFLL-TSFSALGLELWSMTSDIYFDNFIICSEKEVADHWAADGWRWKIMIANANKPGVLK-------------------------QLMAAAEGHPWLWLIYLVTAGVPIALITSFCW. 492
2 -94.800[O] KOG0674 Calreticulin  ali follow..  26  10LLATVGFISAEVYLKENFDN----ENWEDTWIYSKHPGK-----EFGKFVLTPGTFYNDEADKGIQTSQDARFYAASRKFDG--FSNEDKPLVVQFSVKHEQNIDCGGGYVKLFDCSLDQ----TDMHGESPYEIMFGPDICGPGTKKVHVIFSYKGK--------NHLISKDIRCKDDVYTHFYTLIVRP-DNTYEVLIDNEKVESGNLEDDWD-------FLAPKKIKDPTATKPEDWDDRATIPDPDDKKPEDWDK---------------------PEHIPDPDATKPEDWDDEMDGEWEPPMIDNPE-------------------FKGEWQPKQLDNPNYKGAWEHPEIANPEYVPDDKLYLR-KEICTLGFDLWQVKSGTIFDNVLITDDVELAAKAAAEVKNTQAGEKKMKEAQDEVQRKKDEEEAKKASDKDDED....................................... 382
3 -5.980[R] KOG1108 Predicted heme/steroid binding protein  ali follow..  58......................................................................................DDIGTLFTPAELAKFNGEEEGRPYLALLGSVFDVSRGIKHYGSGCSYNFFVGRDAS-------------VSFISGDFETYDPETADDVLTLKPDDLIGL--------AGWRDFYQKDYVYKGRVIGR-----YDEKGALTTYHHKFLELLEQARDAKRQVEELRARYPGEWSEERGTRVTTSGDGKERSWI-GYPRKLYSRGNKSFPDAELDEIDAGGKVAHGDAMLKPYDNCEP.................................................................................................................................................................. 278
4 -5.310[C] COG3761 NADH:ubiquinone oxidoreductase 17.2 kD subunit  ali follow..  41...................................................................................................................................................................................................................................QGGKDSEGRTRRWVIFNGYSEASTIPPG-W----------------HGWMHHRVDTPPSKEDYRPREWQKPHLQNLTSPLAYRPKGSIALPGAQPAERPRVTGEYDA-WTPG................................................................................................................................................ 135
5 -5.290[S] COG5508 Uncharacterized conserved small protein  ali follow..  10........................................................................................................................................................................................................................................NIVTETATGMQNDNDNSPDRPKRPLSPAALRALKEAEERRRAEAPKDMPAELGGRGGLDPARF-----GDWE................................................................................................................................................................................... 76
6 -5.250[S] COG4733 Phage-related protein, tail component  ali follow..  11  42...............................LQSILVNKTPLTDTDGNPVIHGVTAVWRAGEQGFESSGAETALGVEVTKAKPVTRTITSANIDRLRVTF--------GVQSLLETTSK--------GDRNPSSVRLLIQLQRNGNWVTEKDVTINGKTTSQFLASV-------------------ILDNLPPRPFNIRMVRETADSTSLQNKTLWSSYT-------EIIDVKQCYPNT-----------QVDAEQFGGQQMTVNYHIRGRIPSNY---------DPEKRT---W----DGSLKPAYSNNPA---------W--DMLTHPRY-DKWALYAIAQPDGFGGTEPRMTFNAYLSQQRKAWDVLSDFCSACMPVWTFVQDSPSDVVWPYTNSDVVVDDNGVGFRYSFSALKDRHTAVEVNYTDPQNGWQTSTELVEDPE...................................... 421
7 -5.250[M] COG3511 Phospholipase C  ali follow..  75....LFQQKGWNPETQALDPTGITLPYRINTTGGPNGVGECVNDPDHQWIAAHLSWNGGANDGWLPAQARTR----VANTPVVMGYYARPDIPIHYLLADTFTI-CDQYFSSLLGGTMPNRLYEPAIQPKLTFTWRIMPQNLSDAGISWKV---YNSKLLGGLNDTSLSRNGYVGSFKQAADPRSDLARYGIAPAYPWDFIRD-VINNTL-------QVSWVVPLTVESEHPSFPVAVGAVTIVNLIRVLLRNPAVWEKTALIIAYDEH----GGFFDHVT-----PLTAPEGTPGEWIPNSVDIDKVDGSGGIRGPGLGFRVPCFVISPYSRGGLM-------------------VHDRFDHTSQLQLIGKRFGVNLTPWRAS---------VTGDMTSAFNFAAPPDPSPPNLDHPVRQLPKVAKCVPN.................................................... 472
8 -5.150[E] COG4311 Sarcosine oxidase delta subunit  ali follow..  19  15.....................................................................................................................................................................................................................................................................................ELEFAYAGEAHIARPADPSTLSDEEWRDFLFSNPRWRHIHGCGRFFNAVRDTVSDK...................................................................................................................................................... 78
9 -5.000[T] COG5253 Phosphatidylinositol-4-phosphate 5-kinase  ali follow..  11  411..........KIFFTEHFDVFRKICDCQENFIQS--------------------------------LSRCVKWDSNGGKSGSGFLKTLDDRFIIK-HAELEAFIKFAPSYFEYMAQAMFHDL-------PTTLAKVFG------------YQIQVKSSISSSKSYKMDVIIMENLFYEKKTTRIFDLHVEQTGKANEVLLDENMVERASVWNDTLFLA-------KMNVMDYSLVIGIDNEGYTLT---DFIRTFTWDKKLESWVKEPTVVTPRQYKKRFREAMERYILMVPDPWYWEGN....................................................................................................................................................................................... 682
10 -4.970[R] COG3271 Predicted double-glycine peptidase  ali follow..  23...............................................................AILIAIGIPAGASEIKVKCVVPENGTTMLLQVPDVRQSTNYSCGASCFQAVVSYWGGKDMGEGQFIELVNTTLGETDRKGTTPSGIKMGLRAEIRENLTLDD-RLQAWKNEDQTWEMNASSHYMVVIGIDSKNVYFEDPWILGSRGYIPHDEFV--------------------ERWHTFSYASPTADKKTN.................................................................................................................................................................................................................................... 211

FFAS is supported by the NIH grant R01-GM087218-01
8 5 8 8 9   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Ye Y, Godzik A. Comparative analysis of protein domain organization. Genome Res. 2004 Mar;14(3):343-53.