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Query: gi|6319258|ref|NP_009341.1| NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source; Bdh1p (YAL060W) [Saccharomyces cerevisiae], from S.cerevisiae

Results of FFAS03 search in COG0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRALAYFKKGDIHFTNDIPRPEIQTDDEVIIDVSWCGICGSDLHEYLDGPIFMPKDGECHKLSNAALPLAMGHEMSGIVSKVGPKVTKVKVGDHVVVDAASSCADLHCWPHSKFYNSKPCDACQRGSENLCTHAGFVGLGVISGGFAEQVVVSQHHIIPVPKEIPLDVAALVEPLSVTWHAVKISGFKKGSSALVLGAGPIGLCTILVLKGMGASKIVVSEIAERRIEMAKKLGVEVFNPSKHGHKSIEILRGLTKSHDGFDYSYDCSGIQVTFETSLKALTFKGTATNIAVWGPKPVPFQPMDVTLQEKVMTGSIGYVVEAFEEVVRAIHNGDIAMEDCKQLITGKQRIEDGWEKGFQELMDHKESNVKILLTPNNHGEMKLast
1 -79.500[Q] KOG0024 Sorbitol dehydrogenase  ali follow..  26  10.LSLVVHGPGDLRL-ENYPIPEP-GPNEVLLRMHSVGICGSDVHYWEYGRIGNFI---------VKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPR--------------ENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGL-GSEMTTVPLLHAAIREVDIKGVFRY-CNTWPVAISMLASKSV---NVKPLVTHRFPLEKALE-AFETF--KKGLGLKIMLKCDPSDQ.. 355
2 -51.900[ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases  ali follow..  20  1MKAIVWQGVNKVGV-ETVPDPTLLLPTDAIVKITSTAICGSDLHLLDG-------------IPSMETGDILGHEFMGEVVEVGSEVRKLKVGDRVVVPFNIACGV--------------CDPCKRGFFSACDNSALFGYGGYAGGQAQYVRVPFADVFKIESGLKDEQVLLTDIFPTGYQAAEQCNIVPGDVVAVFGAGPVGQFAARSAQMLGAAHVIVIDRVPERLAMAEAAGCQTIN---EKEDVLLSLREATGGR-GPDHVIDAVGMEAALRWAILSCAKGGTVSMPGVYGGLVDKMPIGAAFAKGLIFRMGQTHTHRHIPSLLGRIEAGQIDPSF---VITHRASLDQA-PELYKTFRDKQDCCIKVVLNPWA..... 392
3 -38.900[Q] KOG0022 Alcohol dehydrogenase, class III  ali follow..  24  11.KAAVLWELKKPFSIEEVEV-APPKAHEVRIKMVAAGICRSDEHVVSGN-------------LVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGK--------------CRICKNPESNYCLKNDFVGVS----TFSQYTVVDENAVAKIDAASPLEKVCLI--FSTGYGSAKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATEINPQDYKKPIQEVLKEMTDG--GVDFSFEVIGRLDTMMASLLCCHEAGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNILPFEK-INEGFDLLRSGKS--IRTVLT........ 374
4 -38.300[C] COG1062 Zn-dependent alcohol dehydrogenases, class III  ali follow..  21  4.RAAVAFAPGKPLEIVEIDV-APPKKGEVLIKVTHTGVCHTDAFTLSGDD------------PEGVFPVVLGHEGAGVVVEVGEGVTSVKPGDHVIPLYTAECGE--------------CEFCRSGKTNLCVAVRYMGCS----TFSEYTVVAEVSLAKINPEANHEHVCLL--VTTGIGAVNTAKVQPGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPKKFDLARRFGATDINPNDYDKPIKDVLLDINKW--GIDHTFECIGNVNVMRAALESAHRGGQSVIIGVAGSGQEISTRPFQLVTGRVWKGSAFGGVKGRSQLPGMVEDAMKGDIDLEPFVTHTMSLDE-INDAFDLMHEGKS--IRTVIR........ 368
5 -36.000[R] COG1064 Zn-dependent alcohol dehydrogenases  ali follow..  21  26.......................PRDDDVVIDIKYCGVCHSDIHQ------------ARDEWGNSTFPMVPGHEIVGIVRAVGSQVTRFKIGDRVGVGCFVDS--------------TTCAKRDLDLEQYLPGLVVT--TPTQGGYSDHIVVKEGYVLSIPENLPLDAAAPLLCAGITLYSLRHWKAGPGKKVAIVGLGGLGHMGVKLAHAMGA-EVTVLSQTLSKKEDGLKLGADHYYATKDPETFTKLAGSF-------DLIICTVAAEIDWNAYLNLLKVDGELVLVGI-PENPVPVHAFSLVPARRSISGSMIGSIKETQEMLDFCGEHGIVSE------IETIRMEQ-INEAYERVVRS-DVRYRFVIDMES..... 344
6 -36.000[Q] KOG0023 Alcohol dehydrogenase, class V  ali follow..  22  35.......................NGENDVTVKILFCGVCHTDLHTIK------------NDWGYSYYPVVPGHEIVGIATKVGKNVTKFKEGDRVGVGVISGS--------------QSCESCDQDLENYCPQMSFT--TKNYGGYSENIVVDQRFVLRFPENLPSDSGAPLLCAGITVYSPMKGMTEAGKHLGVAGLGGLGHVAVKIGKAFGLKVTVISSSSTKAEEAINHLGADSFLVTTDPQKMKAAIGTM-------DYIIDTISAVHALYPLLGLLKVNGKLIALGL-PEKPLELPMFPLVLGRKMVGGSDVGGMKETQEMLDFCAKHNITAD------IELIKMDE-INTAMERLAKS-DVRYRFVIDVAN..... 355
7 -33.900[CR] KOG1198 Zinc-binding oxidoreductase  ali follow..  18  3LRYVVHDEISGFD-PEEYEVPQKLNPGEVLVKLKAASLNYRDL-IITKGLYPLPLQLPVVPGS----------DGAGIIEKVGEDVEGFEKGDSVV--------------------CNFFTNYLDGTPTDFATHSALG-GTRDGCFQKYAVLPAHALVHAPKNLSFEEIATLPCAAVGLFGSKEHQVKPGNNVLVLGTGGVSTFALQFALAAGA-NVTVTSSSDEKLEFAKKLGATHTINYKKTPQWASPALKMTNG-VGYHHVIEVGG-EKTLPQSIACLAKDGMISMIGFVTTPNLTSIIGQILNRNANIRGIFVGSVSMFRDMVACIEAKDI-----HPVVDKVFPFDQ-LKEAYEYQWSQAH---KVVLKID...... 346
8 -33.400[KC] KOG0025 Zn2+-binding dehydrogenase (nuclear receptor binding factor-1)  ali follow..  19  17TRQLVYENPPEAIQLKTVTIADKPSADQVLVQWIAAPINPADLNVYPVKP---------------ALPAVGGNEGFGKVISVGSNVSSIKVGDHV-----------------------------------------IPDRSGLGTWRELGLHQENDLFPIDNTLSMEYAAQVNPPTAYRMLKDFIDLKKGDTVAQNGASAVGKHVIQICRILGIKTVNVVDNLEELVKELKDLGADEVITQEELYSRKKKF-------PGVKLALNCVGGRSS-LFLASLLDHGGCMVTYGGMSKQPVDCPTGPLIFKDISLRGFWEKRHEMYQELAGWMKSGEI-----KKQEIVKNRLED-HAKALDTALSKFDKKQFFVLE........ 344
9 -29.300[CR] KOG1197 Predicted quinone oxidoreductase  ali follow..  19  2VKGIRVYGGPEVLKWEDVEVGE-PKEGEIRVKNKAIGLNFIDVYF------------RKGVYKPASMPFTPGMEAVGEVVAVGSGLTGRMIGDLVAY-----------------------------------------AGNPMGAYAEEQILPADKVVPVPSSIDPIVAAMLKGMTAQFLLRRCFKVEPGHTILVAAAGGVGSLLCQWANALGA-TVIGTVSTNEKAAQAKEDGCHHVIMYKN-EDFVSRVNDITSG-KGVNVVYDSVG-KDTFKGSLACLKSRGYMVSFGQSSGSPDPIPLSDLAPKSLFLTSMMHYNET--GEVFANVTSGILKAR-----VNHKYPLSRVA-DAHADLENRITSGSVVLL......... 323
10 -16.700[CR] COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases  ali follow..  16  16..........SVQTLDESRLPE----GDVTVDVHWSSLNYKDLAITGKGKII------------RNFPMIPGIDFAGTVRT--SEDPRFHAGQEVLLT------------------------------------GWGVGENHWGGLAEQARVKGDWLVAMPQGLDARKAMII-TAMLCVMALEDAGVRPQDEIVVTGAGGVGSTAVALLHKLG--QVVAVSGRESTHEYLKSLGASRILPRDEFAESRPLEKQVWAG------AIDTVGDK-VLAKVLAQMNYGGCVAACGLAGGFTLPTTVMPFILRNVRLQGVDSVMTPPERRAQAWQRLVADLPESFYTQAAKEISLSEAPNFAEAIINNQIQGRTLVKVN........ 324
11 -11.900[R] KOG1196 Predicted NAD-dependent oxidoreductase  ali follow..  14  21........ESDLVITSTIDLRVLKGSMTALVKNLYLSC-----DPYMRNRM----RKPDPLSPATAQSFTPGKPISGFGVSIDSGHSDYEEGDLIW------------------------------------------------GWEEYSVITPILHFKIHHTLSYYTGLLGMPGMTAYVGFEICTPKKGDTVFVSAAGAVGQLVGQFAKLMGCYVVGSAGSKEKVDLLKNKFGFDDAFNYKEEHNLIGALKRCFP--EGIDIYFENVGGK-MLDAVILNMRPHGRIAACGMISQYNLK-GLSLITYKRIRIEGFNCFDFHKYSEFLEFVVP----------IKEGKIKYVEDVADGLESAPAHGKNVGKQLVVVSPS.... 346
12 -11.600[R] COG2130 Putative NADP-dependent oxidoreductases  ali follow..  16  25..............LETAQIPE-LQDGQVLVRNHFLS-----LDPYMRGRM--------NDSKSYAQPQPLGEVMIGGTVGEASRNPAYAVGDNVV---------------------------------------------GMFGWQEVGISDGRGMQKVDTRLSAYLGSVGMPGVTAWYGLRIMHPKPGQTVAVSAAGAVGSVVGQLAKLKGCRAVGFAGGKDKCDYVVNELGFDACIDYKAAKDPKELYAMLKEAPDGIDAYFENVGGD-ILDAVLRRMNPFGRIAMCGMIAGYDGQ-NPQLILVSRLTVEGFIVSEMDVWPEALRELGG----------VAQGKLKFRESVAQGLASAPEKGKNFGKQLVK........ 334
13 -10.200[R] COG3897 Predicted methyltransferase  ali follow..  16  62...............................................................................................................................................................................GLARYILDHPESVCGKRVLDFASG-SGLVAIAAAKA-GAAKVLAADIDPWTETAIRLNAALNGVDIGFTGLDLVGKPVDADVLLAGDVFYDRA-FADLLVPWFVELTEKGMIVLVGDPGRAYLP................................................................................... 182

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.