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Query: PF00009.25; EF2_METJA/19-258; Elongation factor Tu GTP binding domain, from PfamA30U

Results of FFAS03 search in SCOP206
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst DRIRNIGICAHIDHGKTTLSDNLLAGAGMISKELAGEQLALDFDEEEAQRGITIFAANVSMVHTYEGNEYLINLIDTPGHVDFGGDVTRAMRAIDGAIVVVCAVEGVMPQTETVLRQALRERVKPVLFINKVDRLINELKLTPEELQSRFIKIINDINNLIRKMAPEEFKDKWLVRVEDGSVAFGSAYNNWAISVPFMKKSGITFKDIIKYCEEDRQDELAEKAPLHEVVLDMVIKHLPSLast
1 -98.800d1n0ua2 c.37.1.8 (A:3-343) Elongation factor 2 (eEF-2), N-terminal (G) domain {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}  ali model 3D-neighbors follow..  41  15TNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEV-LGDVQVYPARGTVAFGSGLHGWAFTIRYAKKFGVDKAKMMDRLWGDSFFNPKTKKWLERAFNMFILDPI.. 279
2 -40.600d2bv3a2 c.37.1.8 (A:7-282) Elongation factor G (EF-G), N-terminal (G) domain {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  43  4KRLRNIGIAAHIDAGKTTTTERILYYTGRIHKEVHEGAATMDFMEQERERGITITAAVTTCFW----KDHRINIIDAPGHVDFTIEVERSMRVLDGAIVVFDSSQGVEPQSETVWRQAEKYKVPRIAFANKMDKTGADLWLVIRTMQERLGARPVVMQLPIGR............................................................................. 164
3 -38.500d2dy1a2 c.37.1.8 (A:8-274) Elongation factor G (EF-G), N-terminal (G) domain {Thermus thermophilus, EF-G-2 [TaxId: 274]}  ali model 3D-neighbors follow..  20  2..IRTVALVGHAGSGKTTLTEALLYKTGAKERRVEEGTTTTDYTPEAKLHRTTVRTGVAPLLF----RGHRVFLLDAPGYGDFVGEIRGALEAADAALVAVSAEAGVQVGTERAWTVAERLGLPRMVVVTKLDKLPIDLPLYEGGKWVGLIDVFHEVPPEERERVQRFRQEVLEAIVETDEGLLEKYLEGEEVTLEKAFHEAVRRGLLYPVALASGEREIGVLP-----LLELILEALPS 267
4 -31.400d4ac9a4 c.37.1.8 (A:1-179) Elongation factor SelB, N-terminal domain {Methanococcus maripaludis [TaxId: 39152]}  ali model 3D-neighbors follow..  35  7....NLGIFGHIDHGKTTLSKVLTEIASTSA---------HDKLPESQKRGITIDIG----FSAFKLENYRITLVDAPGHADLIRAVVSAADIIDLALIVVDAKEGPKTQTGEHMLILDHFNIPIIVVITKSDNAGTEIKRTEMIMKSILQSTHNLKNSSI............................................................................... 151
5 -28.400d2c78a3 c.37.1.8 (A:9-212) automated matches {Thermus thermophilus HB8 [TaxId: 300852]}  ali model 3D-neighbors follow..  33  5....NVGTIGHVDHGKTTLTAALAAAENPNVEVKDYGD--IDKAPEERARGITINTAHVE--YETAKRHYS---VDCPGHADYIKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVP-VVFMNKVDMVDDPELLDLVEMEVR------------------DLLNQYEFPGDEVPVIRGSAL.................................................... 168
6 -25.100d1f60a3 c.37.1.8 (A:2-240) Elongation factor eEF-1alpha, N-terminal (G) domain {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}  ali model 3D-neighbors follow..  25  8....NVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEVLDKLKAERERGITIDIA----LWKFETPKYQVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGVGEFEQTREHALLAFTLGVRQLIVVNKMD--------SVKWDESRFQEIVKETSNFIKKVGYNP--KTVPFVPISGNMIEATTNAPW................................................. 207
7 -24.700d1g7sa4 c.37.1.8 (A:1-227) Initiation factor IF2/eIF5b, N-terminal (G) domain {Methanobacterium thermoautotrophicum [TaxId: 145262]}  ali model 3D-neighbors follow..  25  8.....VSVLGHVDHGKTTLLDHIRGSA--VASREAGGITQHIGATEIPMDVIEGICGDFLKKFSIRETLPGLFFIDTPGHEAFTTLRKRGGALADLAILIVDINEGFKPQTQEALNILRMYRTPFVVAANKIDRIHGWRVHEGRPFMETFSKLDTKVYELVGKLHEEGFESERFDRVTD-SIIPISAITGEGIPELLTMLMGLAQQYLREQL............................ 224
8 -24.200d2lkca1 c.37.1.0 (A:5-178) automated matches {Geobacillus stearothermophilus [TaxId: 1422]}  ali model 3D-neighbors follow..  35  7.....VTIMGHVDHGKTTLLDAIRHSK--VTEQEAG--------------GITQHIGA----YQVTVNDKKITFLDTPGHEAFTTMRARGAQVTDIVILVVAADDGVMPQTVEAINHAKAANVPIIVAINKMDK-LMEYNLVPEE............................................................................................... 136
9 -24.200d4rd4a1 c.37.1.8 (A:2-206) automated matches {Sulfolobus solfataricus [TaxId: 273057]}  ali model 3D-neighbors follow..  28  10....NIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNIGVCESCKKPEAYVTEPSCK--ISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFQPQTREHFVALGIIGVKNLIIVNKVDVVSKEEALSQYRQIKQFTK........................................................................................ 170
10 -18.800d1zunb3 c.37.1.8 (B:16-237) Sulfate adenylate transferase subunit cysN/C, EF-Tu domain G-like domain {Pseudomonas syringae pv. tomato [TaxId: 323]}  ali model 3D-neighbors follow..  28  7KEMLRFLTCGNVDDGKSTLIGRLLHDSKMIYEDHLEAITLVDGLQAEREQGITIDVA----YFSTAKRKFII--ADTPGHEQYTRNMATGASTCDLAIILVDARYGVQTQTRRHSYIASLLGIKHIVVINKMDLN......................................................................................................... 155
11 -16.800d1mkya1 c.37.1.8 (A:2-172) Probable GTPase Der, N-terminal and middle domains {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  20  3.....VLIVGRPNVGKSTLFNKLVKKKKAIVEDEEGVTR-----------------DPVQDTVEWYGKTFK--LVDTCGSQKMKEVTLNMIREADLVLFVVDGKRGITKEDESLADFLRKSTVDTILVANKAENLREFEREVKPELY............................................................................................. 134
12 -15.800d4kyua_ c.37.1.0 (A:) automated matches {Bacillus subtilis [TaxId: 224308]}  ali model 3D-neighbors follow..  21  5.....VAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTR-----------------DRIYSSAEWLNYDFN--LIDTGGLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEEVAKILYRTKKPVVLAVNKLDNTEMRANI................................................................................................... 129
13 -13.700d1mkya2 c.37.1.8 (A:173-358) Probable GTPase Der, N-terminal and middle domains {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  16  6TDAIKVAIVGRPNVGKSTLFNAILNKERALVSPIPGTTR--------------------PVDDEVFIDGRKYVFVDTAG-LRRKSRVEDSIEKADVVVIVLDATQGITRQDQRMAGLMERRGRASVVVFNKWDLV......................................................................................................... 133
14 -11.000d1egaa1 c.37.1.8 (A:4-182) GTPase Era, N-terminal domain {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  24  8.....IAIVGRPNVGKSTLLNKLLGQKISITSRKAQTTR-------HRIVGIHTEGAYQAIY------------VDTPG---MNKAASSSIGDVELVIFVVEGTR---PDDEMVLNKLREGKAPVILAVNKVDNVQEKADLLP................................................................................................. 134
15 -10.700d2gj8a_ c.37.1.8 (A:) automated matches {Escherichia coli [TaxId: 469008]}  ali model 3D-neighbors follow..  18  3....KVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTR------DVLREHIHIDGMP-------------LHIIDTAGLREASDEVEREIEQADRVLFMVDGTTTDAVDPAEIFIARLPAKLPITVVRNKAD........................................................................................................... 123
16 -10.700d3t5ga_ c.37.1.8 (A:) GTP-binding protein RheB {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  25  6...RKIAILGYRSVGKSSLTIQFVEGQFVDS--------YDPTIENTFTKLITV-----------NGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTEVIKVIHGKLLDMVGKVQIPIMLVGNKKD-LHMERVISYEE............................................................................................... 132
17 -10.400d1wf3a1 c.37.1.8 (A:3-180) GTPase Era, N-terminal domain {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  24  8.....VAIVGKPNVGKSTLLNNLLGVKVAPISPRPQTTR-------KRLRGI------------LTEGRRQIVFVDTPG---MDQEVYEALADVNAVVWVVDLRHPPTPEDELVARAPLVGKVPILLVGNKLDAA......................................................................................................... 128
18 -10.200d2fh5b1 c.37.1.8 (B:63-269) Signal recognition particle receptor beta-subunit {Mouse (Mus musculus) [TaxId: 10090]}  ali model 3D-neighbors follow..  22  1...RAVLFVGLCDSGKTLLFVRLLTG--------------------QYRDTQTSITDSSAIYKVNNNRGNSLTLIDLPGHESLRFQLDRFKSSARAVVFVVDSVKDVAEFLYQVLIDSMALKNSPSLLINKQD---IAMAKSAKLIQQQLEKELNTLRV................................................................................. 142
19 -10.200d1nrjb_ c.37.1.8 (B:) Signal recognition particle receptor beta-subunit {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}  ali model 3D-neighbors follow..  12  4...PSIIIAGPQNSGKTSLLTLLTTDS------------------------VRPTVVSQEPLSAADYDGSGVTLVDFPGH--LSDYLKTRAKFVKGLIFMVDSLTTTAEFLVDILESSCENGIDILIACNKSE---LFTARPPSKIKDALESEIQKVIERRKKSLNEVERKINEEDYAENTLDVLQSTDGFKFA.............................................. 180
20 -10.100d3w5ja1 c.37.1.0 (A:2-197) automated matches {Gallionella capsiferriformans [TaxId: 395494]}  ali model 3D-neighbors follow..  15  1...KRIALLGMPNTGKSTLFNRMTGGAARVGN------------------GITVELLSGKILLGADM----VEIIDLPGIYDLHGQVVRHFLHDNVPDLALVILNATQIERQMSLLLQLKQLNMNIVVLNMSDEAKQYITIDSRKMSELLQIPVFQLSGKYGTGYQE......................................................................... 151
21 -9.700d1puia_ c.37.1.8 (A:) Probable GTPase EngB {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  11  14DTGIEVAFAGRSNAGKSSALNTLTNQKSLATSKTPGRTQLIN-------------------LFEVADGKR---LVDLPGY----AEVPEEMKRLQGLVVLMDIRHPLKDLDQQMIEWAVDSNIAVLVLLTKADKL----------ASGARKAQLNMVREAVLAFNGDVQVETFSSLKKQGVDKLRQKLDTW................................................. 186
22 -9.340d2evwx_ c.37.1.8 (X:) cH-p21 Ras protein {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  19  5....KLVVVGAGGVGKSALTIQLIQNHFV--------DECDPTIEDSYRKQVVI-----------DGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINEDIHQYREQIKRVKDSDDVPMVLVGNKSD--LAARTVESRQAQD............................................................................................ 132
23 -9.170d3gj0a1 c.37.1.8 (A:2-207) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  20  11....KLVLVGDGGTGKTTFV-----------------KRHLTGEFEKKYVA-TLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPF....................................................................... 160
24 -9.160d2cxxa1 c.37.1.8 (A:2-185) GTP-binding protein engB {Pyrococcus horikoshii [TaxId: 53953]}  ali model 3D-neighbors follow..  18  2....TIIFAGRSNVGKSTLIYRLTGKKVRRGKR-PGVTRKIIEIEWKNHKIIDMPGFGFMMGLPKEVQERIKDEIVH---------IEDNAKNIDVAVLVVDG-RGEIPIDVEFYQFLRELDIPTIVAVNKLDKI......................................................................................................... 134

FFAS is supported by the NIH grant R01-GM087218-01
8 5 8 4 5   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Zmasek CM, Zhang Q, Ye Y, Godzik A. Surprising complexity of the ancestral apoptosis network. Genome Biol. 2007 Oct 24;8(10):R226 [Epub ahead of print]