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PF13166
Query: PF13166.1; Q63PW4_BURPS/9-780; AAA domain, from PfamA26U

Results of FFAS03 search in PfamA26U
Master-slave alignment does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst SFGCFSDFAWNAEVRDHGNNVAKFKKMNVIYGRNYSGKTTLSRIIRSLETGSISPRYASPSFSITISGAVITNNNIPAQGHDIRVYNKDFVDEHLAFLRDEQGHISPFAVLGSKNKEIEVEIDKLEDELGSVENKTGLRHSYQEKKKAHADKKKAAQDAQDELDKKIFDKANKNPTGIKHNSLYKDANYDVRKLKLDIKTVQDKKIAPLDDADRSSKVKLLSEVALPDIEKRLSFNSSLPALAKSTVELITKKIKPSAPIQELLNDAILQNWVKSGIPLHEATRETCGFCGSPLPADLWKRLGDHFNQESQDLEKDLDSVLTKISNEKTRIKNVVTVDRKNFYSANQATFDNLKADLDDAINNHEKSLQSLEDELNARKKDIFTERSTIDVQDNTVSISQKVSLVNELIERNNKTTTSLEEDQKIARNELRLSEISQFTIDIDLAGEEKKIKALEDQITKAKDELDAVEAEGKKRVDRVKELRTQLRDEKRGAEQVNQYLGHFLGHGGLSLSAVEEANTATYRFQILRGDQAAYNLSEGECSLVAFCYFLAKLEDIETKGKKLIIYIDDPISSLDSNHIFFVFSLIENYITKPIEDANGKTILDGNGRPTYRYEQLFISTHNLEFLKYLKRLTKPAKDSESFLITRKQSSSAIGLMPTYLRNYITELNYLFGEIYCCSDANNANSHYHSFYNFGNNLRKFLESFLFFKYPFSISDRTDHDKRIKMFFHDGTNSQAFVERLTNEFSHLGEFIDRGAQPIDCAEIAAVAKFVLKLast
1 -162.000PF13166.1; Q63PW4_BURPS/9-780; AAA domain  ali  100  1SFGCFSDFAWNAEVRDHGNNVAKFKKMNVIYGRNYSGKTTLSRIIRSLETGSISPRYASPSFSITISGAVITNNNIPAQGHDIRVYNKDFVDEHLAFLRDEQGHISPFAVLGSKNKEIEVEIDKLEDELGSVENKTGLRHSYQEKKKAHADKKKAAQDAQDELDKKIFDKANKNPTGIKHNSLYKDANYDVRKLKLDIKTVQDKKIAPLDDADRSSKVKLLSEVALPDIEKRLSFNSSLPALAKSTVELITKKIKPSAPIQELLNDAILQNWVKSGIPLHEATRETCGFCGSPLPADLWKRLGDHFNQESQDLEKDLDSVLTKISNEKTRIKNVVTVDRKNFYSANQATFDNLKADLDDAINNHEKSLQSLEDELNARKKDIFTERSTIDVQDNTVSISQKVSLVNELIERNNKTTTSLEEDQKIARNELRLSEISQFTIDIDLAGEEKKIKALEDQITKAKDELDAVEAEGKKRVDRVKELRTQLRDEKRGAEQVNQYLGHFLGHGGLSLSAVEEANTATYRFQILRGDQAAYNLSEGECSLVAFCYFLAKLEDIETKGKKLIIYIDDPISSLDSNHIFFVFSLIENYITKPIEDANGKTILDGNGRPTYRYEQLFISTHNLEFLKYLKRLTKPAKDSESFLITRKQSSSAIGLMPTYLRNYITELNYLFGEIYCCSDANNANSHYHSFYNFGNNLRKFLESFLFFKYPFSISDRTDHDKRIKMFFHDGTNSQAFVERLTNEFSHLGEFIDRGAQPIDCAEIAAVAKFVLK 772
2 -30.900PF13514.1; B5J9R5_9RHOB/33-1144; AAA domain  ali follow..  10  549......................................GQLRQIEQAEVEAQIRLEQADKRLEVLDKELTALDAAVGAAARQAGLTSTITSAEWLDWVARNSTATEDAQALFAAREEHQPILDRAEDLRAELSRLLTFEATDVASALTVARQVAEGERKQSENEARAQETLQQAKRNLR------KREERHQAALSVEAEARNAWYTLILEMLGDRIAPENLQASLEPLRELREHAKTRASAAQRVASMKVDQERFAEEVAALAKAYNLETLETAAETFSALKT----------RARSAHEAVEKLTGDIKEAEARKSKNSEKLREIKQAIEAIASGFPYSTSLTEIDELRTVVKRAQQVIEERAALVKLQRTVVSELGVNDIKAAREEMAALSLTDLEAAFENSKSDLERAEEELTQAIEIRVAAEQGV-----AQVTGDADIATLVEQKATLELQLEDSALEHLELSLGHYLASNSIRRYRDSHRS--GMMTATERCFASLTQGAYPSLITQVDKDAEVLLAVDCTGASRAAEMSKGTRFQLYLALRAAAHEQLVAQGTRLPFFCDDIFETFDEDRTSAACRVMETI---------------------GSRGQAIYLTHHRHVVDIAMKVCDT......................................................................................................................................... 1105
3 -27.400PF13175.1; A9A6W0_METM6/4-391; AAA ATPase domain  ali follow..  12  3KFRI-KNYK---SIKDSGDVYLSPDNITILAGMNESGKTSVLEALEDFNVGK-------------------------------------------------TVRESAKPICGNLDPEISLFFKLNVEELEKISKDISNIYLSNDFSKNIELEVKKVGSTYFLENNDIYSCLEDYNIGII---------------------------------------------------------------------------------------------------------------------NTLVEIENEINTLSKNIDVIFPTEFNSVEEFRKIMDQKIKDGKSKITDDFNEKIKTQLNALFDEAQKYTLYFLDIDKTLINYIENVVKKEYIPNFIIFKTYKDSKIPNIIPFANL----------------------------------ETDEFIKDLQKVSNLDINLIKSTDRQRKK------------NHHGAININLQEDYSKYWTQSESNLEITWDNNNVEFWVKEDNTSYTPEQRSKGKQWHLAFYIRITA---RSKEGKNNILLIDEPGLFLHAQAQEDIINKLEDASKTM---------------------SIIYTTHSPYLL.................................................................................................................................................. 388
4 -18.100PF02463.14; SMC_BACSU/2-1172; RecF/RecN/SMC N terminal domain  ali follow..  12  675......................................................................................................................SRELEDVTKRLAEMEEKTALLEQEVKTKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQVAEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEE------DIDRLTKQKQTQSSTKESLSNELTEL-----------------------------KIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSFLTSEMSS--STSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTERELKEMKRLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKRVKLIKLAIEEL-DEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMTKRFGRAELRLTDPNDLLHSGVEIIAQKKLQNLNLLSGGERALTAIALLFSILKVRPV----PFCVLDEVEAALDEANVFRFAQYLKKY---------------------SSDTQFIVITHR...................................................................................................................................................... 1149
5 -17.000PF12128.3; Q8EAA0_SHEON/1-1188; Protein of unknown function (DUF3584 topsan)  ali follow..  10  19...........................TNICGTNASGKTTLQRLVPVFYGEYPSRVVPSTRDSFE-------------HDSSYIIYERAIIQNDRTLLSTGSNRSELRAYARQDGEHSLRHIEKLAKAVHSKEGKMETVKSMIAAILEEDGVNPPSSRLNPQRVEAWIRESQLIQGFEVIRPEFEKLEQEFNQLLSAEMRLSSLSRGYRNDESLEADRLEIQQTLSKELNLKLRMKEVRDELNLDLSAAKGDVAKCEYELDAIEDQ--HGAFLDANIEQAKADLDMLPNWRADMENEKHQDIEAAYNARRSKIGEQLNRELEGLHSEQDKQREARDKQREVARGDLDALEAQWRSQMDAGKASFSEQEYQFKLNAAELKLRVDGVTYTEEEKLNLAIFDERIHRADEEQESCNAKVERLTSDERKLRAKRDQANEALRIASLRVNERQTALDELHHMLFPQSHTLEFLRKEAQGWEQSLGKVIAPELLHRTDLHP..................................................................................................................................................................................................................................................................................... 568
6 -16.600PF04094.9; Q8S5S8_ORYSJ/246-1073; Protein of unknown function (DUF390 topsan)  ali follow..  10  382................................................................................................................TVLDGLSAQMEVLQAERAELDAAWARVEEGRRSVEAMVEAGRKHRRHTSELEARRRDLAEIAREVEEERETALIATTVLNEARDDLRLQYGSRAAELEKDAARGVLDAAAARERRAAENEAASRQREEALEARATALEERARAKERDMADREAAV----------------------------AIREATLAAH-EAACAEEESALRLREDTLTERGRALEEAEAAAQRDSLFLREAAREEQARRNLEGARAKRAALDQRVAELEARAKELDARAHSGGAAVGDGDLAARLAAAEHSIAELQGALDSSAGEVEALRLAGEVGPGMLRDAVSRLDRAGRQAGLWGGRCAKYAANQGGLAQRLSEMAGTLQRLPEELEETIKSSSRLARGAVELVLASYQARDPDFSPWAALEEFPPGTEDGARAQVRDGTAPRLAFA--LDSDEEGGDDGAG-----DDPGAS....................................................................................................................................................................................................... 828
7 -16.200PF05557.8; Q9W6G9_XENLA/2-716; Mitotic checkpoint protein  ali follow..  10  169..............................................................................................................LQWKIMNQEMQIKTQETEKQELTEQLEIHRKKLQESNEKMQALHELQAQNADNEQKIKSKLSAQEQDAAIVKSMKSDLTKLPKLERELQQLRDENAYHREMKENNALLKEEVEGLRRAAERFNKMKEDLVGSEIEKEQLVKKLKLWENLEQSTGLNIRTPDDFSRQIMAVQQRELK------------LKEENMTIQISARMLETSRQQLQEELLKVQSGFLEE---------KKRREHQEALVRRLQKRVLLLTKERDGMRAILDSYDSELTPTEHSPQLSRRLKEAEDILQKVQDHNAEMETQLSEALEDAGIQKQKSELLTAELKVLKSQMGSSDQNISFTNEAMSALRLKIEELEAERGRLEEENKILEMRLESLNLQGCYDPSRTKVI............................................................................................................................................................................................................................................................................. 543
8 -16.100PF13779.1; A9D7X3_9RHIZ/37-855; Domain of unknown function (DUF4175 topsan)  ali follow..  393..............................................................................................................LAAAVVEQRGVLALDAQNLPRVFDLHDALTIAPEETIPDLSHYLLLQSVRGRLENARSDEDLHAAIDYMWGVALQLEDGNLSLAERRLRDAQNALAEALENGATDEEIAQLMD-----------------ELREAMQEFLQELARQNQNNPASEMQQAMPENMLRQRDLDNML--------DQIENLARSGARDQAQQMLQELQRMMNNLQAGRQQRQQQQGGPMRQQMDKLGELMRQQ-QQLMDETMRADRDRQSQSGEGRDRQEQGQNQPGQGQDQGQQGQGSQSLEEMLGALGRSQQELQDALGQLQRDLEGMGINPSEGFGEAGEAMGDAAGNLQQ-GQTGQALGDQGRALQALRQGAEDMMNQMMQAMGNQQGDAEGEGPDQNGNRSADDRDPLGRPRATTGPDFGSRVQVPDEQRAREILDAIRKRL----------DQLSPEVEKRYLLLD............................................................................................................................................................................................................ 819
9 -15.700PF15324; H0UVS3.1/99-1343; Hedgehog signalling target  ali follow..  2...........................DIFISQYSVGKDALRTILKQ--KAQSIPIFKEVKVHLLDDAGVEKVAAPPEARGSPS------IDSATAVAAATAAAIATAAPLIKVQSDLEAKVNSVTELLNKLQETDKHLKRVTEQQTSIQNKQEKLYDHEKQMNVFMEQHLKHLEKLQQQQIDIQTHFISAALKTNTFPPASTLAPRAMEKHSREPGCPFVGGSMLSSHEPFASKQATLRKVEDTYFDEQESPLETPAPRRFAPVPVSRDGEMPKRENPMEEKENM----EKSDYKGNTRLLGQILNNNDSSTRKSESSDITSLSRSKLGWNPERRHRFPSSGEPGTAIVTQKPNDVLQDLGQKRKETNSVLQAKRISDNVELADLPQSSCKLQTTNTRSVLKDAEKILRAVQNNKKMLEENLEAIIRAKDGAAMYSFINALSTNREITEKIRIRKTVDEWIKAISAEIQDELARKDFEQRRFAQKNQRTQKAQIMSKDIKANTQDKTVNKSVILKKPQKQVEDYFRSPPARSMAVSSLQKERKA---YMSQVYGKAVYQGHRSTLKRGPYLRFNS.................................................................................................................................................................................................... 553
10 -15.700PF15964; Q5PQY1.1/1-716; Centrosomal colon cancer autoantigen protein family  ali follow..  306.........................................................................................................QTIETLTKERDDLMSVLVSVRSSLAEAQERETSAYKQVKHAVQMTEEANFEKTKALIQCEQLRSELERQTDRLEKELASQQEKRALEKEMIKKEVTREREEAEAKMLILSQNIAKLEAEIEKITREKTSAVSQLEEVQNQLASQEMDVTKVCGEMRFQLNKTEKDEAEKEHKEYKAKSQKDLEMKDQEIEKSESTQQVEQEQQKAARARQECLQVTELLGESERQLHLT-RLEKDSIQQSFSNEAKAQALQALQREQELTQKIQQMETQHDKTDSEQYLLLTSQNLTKLKEECCILAKKLEKVSLKSRSEIVQLSQEKRYLCDKLEKLQKRNDELEDQCVQHGRVHETMKERLRQLDKHGQATAQQLVQLLNKQNQLLLERQNLSEEVDQLRAQLPSM............................................................................................................................................................................................................................................................................. 711
11 -15.400PF09787.4; A7USX6_ANOGA/12-516; Golgin subfamily A member 5  ali follow..  12  102.............................................................................................................SIEQELAAIKIVLAEIKAERDELKSELDSTLSQQLSNGETESKLLDLEVLCQNLSEEKMALAGKLLSLEEANGKYVKSISELESTIAKHIQSEQELNSKLDMAR----------------LETENALTELQQYRVRAHATLQLKEKTIEQLKEQMSGSGRTDSTDS-------------------TDSKHSNAEQILQIELEQTRQEKANLAEELTSLNDRMKQR------------EAQWMNAEEKLRVTVHALEQNVQRLQQQILLDADKFSVLED--DFKLKQRELASVREDLIKQRTSFTLRLHEKESENSKLRNKIHTRPVSPL------NDQEDRLASLTQSLVQKQTALETVTVERNALRIQLEKLENQYRNTASQVRQQRAVYLN.............................................................................................................................................................................................................................................................................. 439
12 -15.300PF11398.3; Q6D3T4_ERWCT/1-377; Protein of unknown function (DUF2813 topsan)  ali follow..  10  10GFRGINRLS-------------TLDENNVLIGENAWGKSSLLDALSLLLAPTLPL------YHFDMQDFHFTPGDENSREKHLQI------IFTFCETAPGHHLSPRYRSLSPVWVEGNESLYRVFYRLEGEVDESQSVFTWRSFLDADGHPIPL----------------------------------------------------------------------------------------------------------------------------------------DNIDELAREIIRLHPVLRLRDARFMRRLRSGTLAATLDNSNE-----------------------------------------------------------KLAQQFEQLIRELVQNPQKLTD----------------------------------KELRQGLVAMQQLLEHYFSEQNATGNDRRHHRHARTHNGKSWRSLDNINRLIADP---------------------------------NSRSSRIILLELFSTLLQAKGSVVLDPLLLIEDPETRLHPIMLSVAWGLLTQL-------------------------QKVTTTNSGELLSLVP---------EQVCRLVRESSRVATYRIGRQGMNAEDSRRIAFHI.................................................................................................. 370
13 -15.200PF10186.4; B2WCB9_PYRTR/2-373; UV radiation resistance protein and autophagy-related subunit 14  ali follow..  11  1.............................................................................................................................................................................................................................................................................................ECDICGRDGSLSQPLHCITCARAYLEHPRIELAKTLIDLDGVEKHVKAIINGSEDKAIQHVSLTDSKGGLLVDRQECTNNLNWQRTKAETAEIQERLG------NISDHAHQLRQQMEATRKLLEAKRAANAQRKSDLSSATYGIESRRAN------ELDKVQQKVKRLDYNADKMHHDTIDLRMQLCTTAAKLAGLKMQRRKTRDGGVKEVFNIGPGSRLRIYDLRDMNDVAPDSLSASLAAVAQLLVRVAA.......................................................................................................................................................................................................................................... 241
14 -15.000PF15921; G3SYM2.1/1-1109; Coiled-coil domain-containing protein 158  ali follow..  402..............................................................................................................LWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNMQTECEALKLQMTEKDKV--IEILRQQIENMTQLVGQHGRTAGA--MQVEKAQLEKEINDRRLELQEFKILKDKKEAKIRELEARVSD--LELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTCRSELNSLTEDYEFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNASKEKHFLKEEKNKLSQELNTVATEKNKMAGELDVL............................................................................................................................................................................................................................................................................. 794
15 -14.900PF10212.4; KRLAQ_CHICK/256-770; Predicted coiled-coil domain-containing protein  ali follow..  11  123..............................................................................................................LKARNMELHRDMKRLTAIFEKLHTYVSLLALPSTKFTNIAASLHGSHDILKDISKHYSQKATLEQDVPTATQKLVTTNDCILSSILSLTNGVGKIASFFSNNLDHFTSSLSYGPKGGTEFISPLSAECMLQYKKKAVAYMKSLKKPCADSVPYEEALANRRVLLSSTESREGLAQQ---------QQSLEKIAK-LEQEKEHWMLEAQLAKIKLEKENQKLKNSLSGHLAETVQERSSNTAEQKEETTEKSQREPIKTTSLIGMLTITTDNEKVPDVESREDLIKKHYMARIAELTSHLQLADSKSVHFHAECRALAKRLSLAEKSKESLTEELKLASQSISRLQDELMTTK---RSYEDQLSMMSDHLCSMNETLTKQREEIDTLKMTSK............................................................................................................................................................................................................................................................................... 515
16 -14.900PF05622.7; HOOK3_HUMAN/5-718; HOOK protein  ali follow..  11  198..............................................................................................................LDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVE----QNRLSEDKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKK.............................................................................................................................................................................................................................................................................. 602
17 -14.600PF07902.6; Q1CPP5_STRPB/1-621; gp58-like protein  ali follow..  1............................................................................................................................MSRDPTLLIDESNLTIGSDGRAYYTFKADGDTKSVKLANNKCIGTTRFNQLMIERGGKPTNYVAPVVVEGSGESTGLFKNLEGALSQLKELNL--ELTDTVNSQLWAKIKLTTNGMLREYHRDNITTEIVESANGIATRISEDTDKKLALINETVSGIRRDY-----QDADRQLSSTYQAGINGLKATMANDKNDLKAVIQATAQGLSQKYDDEIQQLSAKITTTSSGTTEAYESKLADLRAEFTRSHQGMRTVLESRISGLQ-STQQSTAYQISQEIKNREGAVSRVQQDLASYQRRLQDTEKNYSSLTQTVRGLQSTVSAPNRGLESRVTQLAGLIEQKVTRGEMESYIRGAGDSIMLAIKGKLPQSKMSASEI................................................................................................................................................................................................................................................................................ 368
18 -14.600PF14073.1; CEP57_HUMAN/68-245; Centrosome localisation domain of Cep57  ali follow..  12  2.................................................................................................................................................................................................................................................................................................................IFSALKNLQDKIRRLELERIQAEESVKTL------------SRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLL------AAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIF................................................................................................................................................................................................................................................................................ 178
19 -14.600PF05667.6; CCD22_AEDAE/1-554; Protein of unknown function (DUF812 topsan)  ali follow..  210..............................................................................................................VPSLIAANDGAIKTNAKGAIDEVDRQVKLPAINEKLLQYYSKGGTKHRLAEPSGAAASSGTTEKVVLNNITVETKPGKTPLESLQEEIDALQQEIVQHSEEGVQLESSRKETDESIEEYRKTIVRLKEEKKIKERTHILLEDPEVNVKKLEAIIAAG----------------------------GERMKKLQDQWDAHRIPLVDTLEAYRLKNSDKLSKSQQVLDQ----------ESTRQKCEEVVIDLQTKGAMYARLQKEFEKLNKTVSRTAYTSRILEIIGNIRKQKNGIDQILQDTRSLQKEINNITGQLDDDLIFRNAKKDEHSKRAYKLLVTLHSDCEELIKLVQETGAIKREVRDLEDQIENEKGR............................................................................................................................................................................................................................................................................................... 553
20 -14.500PF07888.6; Q7ZTT2_DANRE/1-545; Calcium binding and coiled-coil domain (CALCOCO1) like  ali follow..  6...........................SVHF-RD--AVSTISSQHD------------------------------WSSRDWIGLFKVGWLTVKDYYTFAWALAPEGYQKGADANCSVAFHPSYLPIPGVEEYQFVYVDGRDVCAISSQFTFAAPRPLDELVTLEKSGEGEEDGDDLLLVVPKALILQNLLEGCQRELHELHKKFEAVNGDVE--NERQRWKTDRDEFEILRSDMRSQIEQLKTNLRHSTEKTEELERKHKEAQSSSESMSAEFNALLAERAENQQ-----KELEQDSLTQQKQDIEAELERMKERVKKMTIQRRDEETERIDLQLENEQ--MHADLRTLQERLEASERSTGALRRDLSELGSLQSHSHAELHQVRL--QSAQMSLQLSQANLALREGQSTWAQERETLRQSAELDKDRVQKLSRELQKKEEWLQEERSEREKLEVELGIEKDCNRELRASLRALQKEQEQHQLEKQELLDHIHVLELRLDT.............................................................................................................................................................................................................................................................................. 453
21 -14.400PF15254; G1T8F1.1/39-892; Coiled-coil domain-containing protein 14  ali follow..  11  349..................................................................................................................AEQEDSEIQRLITEVEACVSELPAVSGNTNIQVEIALAMQPLRSENAHLRSRILNQRLREQEKTKKTTGSVECNLELFSLQSLNMSLQSQLQESLKNQELQSKNEELLKVIENQKDENKKYTSIFKEKDQTILENKQQFDIEITKIKIELEEALVD--VKSSKFKLDTAEKENQILGITLRQARLRELTRTLQNSMAKLLSDLSVDSARCKSGNNLTKSLLNIYDRQL----QHDPAPAHTSIMSYLNKLETNHSVAHLEPLSTIKNEETTEPDRPYENVLKQDSDAENETLTVIEDECNLDSTVYIPFVRSTSKMNSPLSKRLSPQPQMSVAITQLVGNSGLVSETEKKLCAHAVTCSSRQEVEDAHEKLSRTADTEDKQLLKKIKEAIGKIPVAREDPEATCQGPSACHKSSIRVKGSTACDGS-SISSFSTFTSL---DEQDFRNGLAALDANIARLQKSLRSGLLE............................................................................................................................................................................................ 853
22 -14.400PF10168.4; Q707M9_XENLA/4-726; Nuclear pore component  ali follow..  402.........................................................................................................................FNRLEKFLSSGEEDKDSLQELAAEQKCLVEHILCTMPLRCRLPSPIQGFWIISDLFLGTSMICITCDFECIARPLLTTIRPPSPPLLCSQIDKSSTEILPHVLADVKGPFEIHIRGILRRNSANPLLLNSSSKDSSPPPEECLQLL------------------------SRATQVFREEYLLKQDLAKEEIQRRVKLLIAQKEKQLEDVRYC---------REERKSLTETAEHLAEKFEEAKERQEDLINRLKRILRSFHTQLP--VLSESERDMKKELQATTEQLQHLGNCINQVKRKMSYQEKQMEKGK----------SPRKSSLTLSDYQKKNIKTVLKEHGEHIQEMVKQINNIRNHVN............................................................................................................................................................................................................................................................................................. 722
23 -14.400PF05483.7; SYCP1_RAT/28-813; Synaptonemal complex protein 1 (SCP-1)  ali follow..  12  289................................................................................................................EKKDHLTSELEDIKMSMQRSMSTQKTLEEDLQIATKTIYQLTEEKEAQMEELNKAKTTHSLVVTELKAEELLRTEQQRLENNEDQLKLITMELQKKSSELEEMTKFKNNKEVELEELKTILAEDQKLLDEKKQVEKLAEELQGKEQELTFLLQTREKE---------------------HDLEVQVTKTSEEHYLKQVEEMKTELEKEKLKNIELTANSDMLLLENKK--LVQEASDMVLELKKHQEDIINCKKQEERMLKQIETLEEKEMNLRD--ELESVRKEFIQQGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKSKNIEELHQENKALKKKSSAENKQLNAYEIKVNKLELELASTKQKFEEMINNYQK.............................................................................................................................................................................................................................................................................. 661
24 -14.300PF04582.7; Q9DPB5_9REOV/1-326; Reovirus sigma C capsid protein  ali follow..  1.............................................................................................................................................................................................................................................................................................................MAGLNPLQRREVVSLILSLTSSTTTNPGDLTAV---------YERLTNLEASTKSLRQSLSSIVSDLSDVSVDLQDTTRALD------DAIATLKGLNTTVAALQNSVASLSSTVNGLTDISSAHSEALSFLRTTIDGNTVAISNLKGDVSTNGLNIADLQNRMKSLESSTSHGLSFSPPLSVADGVVSLDMDPYFCSQRV.............................................................................................................................................................................................................................................................................. 186
25 -14.200PF15934; B4NYC9.1/468-698; Yuri gagarin  ali follow..  41........................................................................................................................................................................................................................................................................................................ELRSQQEQKHTALNEHLACQIQGLEDNLKDRDNQINQLQSMIKSYSDLTENSRLKGEIHDLKLKNCDLSRQLRELSSLMRNQEDQRV------ELCSKYENLMTNFEDQCQELKGAKRKVQSLQSRLDQVEKLQDELRTERKMLREEVIALKEKEAVSAGRERALQEQQKIGHLELEKMRNHIRNMQDHLQLDDI......................................................................................................................................................................................................................................................................................... 229
26 -14.200PF03999.7; PRC1_HUMAN/37-615; Microtubule associated protein (MAP65/ASE1 family)  ali follow..  1.........................................................................................................................LQRTEVVKKHIKELLDMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEIYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEALDHTPDTSFERDVVCEDEDAFCLSLENIAQKLLRQLEEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASD--PNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSK............................................................................................................................................................................................................................................................................................... 383
27 -14.000PF01576.14; O44934_LOLPE/1067-1925; Myosin tail  ali follow..  482................................................................................................................GALEQEEAKVMRATLEISQIRQEID--RRLQEKEEEFDNTRRNHQRAIESMQASLEAEAKGKAEALRIKKKLEGDINELEIALDATNRGKAELEKNVKKYQ--GQIRELQSQVEEEQAQRDEAKEHYQMAERRCAAINGELEELRTILEQAERARKAAENELADASDRVNELQA--------QVSTVGSQKRKLEGDVTAMQSDLDELNNELKDADERAKHAMADATR--LADELRQEQDHGLSVEKMRKSLESQVKELQVRLDESEAAALKGGKKMKLESRVRELEAELDSEQRRHAETQKSMRKVDRRVKELSFQQEEDRKNYERMQELVDKLQNKIKTYKRQVEEAEEIAAINLAKFRKVQQELEDAEERADQSEGALQKLRAKNRS.............................................................................................................................................................................................................................................................................. 859
28 -13.900PF10174.4; Q7Q0K7_ANOGA/59-838; RIM-binding protein of the cytomatrix active zone  ali follow..  318................................................................................................................ELEDKAKEDVDMIRERLDKCQTDLRRAQSEKDNQAEIERLTYELDRSHNLYTKQTASLDSAQEEIARYGLEIEKMRERYEKTAAELRRLQENESFSREARRMKDENDRLREKYDKVIVELENFRGKSQYEQETFDKMKEKFETRENEFQTMELKLHETSLQLDLARAEVTKLIS--------NQDKQRADAERAHIEYEKIRDKHEKLIKEVERLRQNPQSAISPGALAATSTVSLADKNELDRLRDRLEKALQSRDATEMEAGRLAKELEKQLHLTKQQEVYEATRIEFERMSAELTRVLERLEKSEAEKETLRQSTKIYE-KHHQQHASNHHIEQSLMKLEADNKQLMAERDQLVMQLEKSQDMLMSFQQELNAAEVELQRQCEENRRL............................................................................................................................................................................................................................................................................. 701
29 -13.800PF13304.1; B1HP30_LYSSC/55-363; AAA domain  ali follow..  10  2...........................AFIFGPNGSGKSNLFTALKVL---------------------------------------RTLLFNFENLNNVKQLRLPYQPFKLGSQQGQPTEFM---------------------------------------------------------------------------------------------------------------------------------------------------SLFLDGALYYEIQYNASIILYERLHKTTHNLKEELFVRRWDGVDYSYETAHSTAQELTKYTRN-NTAFISVLHVFNDSDALKVFDWFLHKMLFLDEANRLSSHPLIRKLEE----------EPFKKEVIKLLKIADFSIQDVT----------------------------------ARRVERREKNTIGYEFDSPEVIQEVDIDLHYLSFDESGVPIGNETINWTMD--------------------------------------SKGTVRMLHLACVMVDAYNKGK-----TIFIDEFDTAFHVSICEFLMAIMNS--------------------KRNTSNQFVVTSHEIELLD................................................................................................................................................. 309
30 -13.800PF08580.5; Q6FY01_CANGA/41-592; Yeast cortical protein KAR9  ali follow..  10  1................................................................................................................SSIEDLCDVLEWITTQMNRILEIFPQIIDSTGIEVSSLLEYLDWLQERKELLFELVNDINSIGPFLSDILEGIEANLNTDPNKSLDEHEMHLIDLIERCSTLRDDLDPWLNKLRKLLDATLEFKEISNDHMDGLDKVVSENIQSCFDIQEERFTSPVRHAPSFTLEQIVDLLKQ--------NSDSNAISVPTFNKQEKLISERFLELRRSVPAIEKSLTDILPNRIDNFARRDMTNIDSLAEFLRDKYKVLMKKYEFMSSEISELNAELIDKRWNILFVNLNHEINFILDDYEKLKKKLNS-VEEIGINVQIREKMSHQMTQKSLTIERTFKVIFKAQEFSLLD-AGIASKTNEMKNRWEKVRVDDKLLRSVSVDSGPEISSVTKDFES.............................................................................................................................................................................................................................................................................. 380
31 -13.800PF06160.7; EZRA_BACP2/3-562; Septation ring formation regulator, EzrA  ali follow..  97...................................................................................................................SKAKQVLTHIEDLLSAADSNI---EDILKEIADLVTSEEQNRKDIEKVKEQYQTVRKNLLAYSHLYGTLYDKMEQDLDEAWEGIKQYEEETENGNYMKARKILLEQDRRLDQLQLYINDVPKLIADCKQTVPGQLTKLKDGYQEMSEKGYKLEHIQITKELETLNKQLARAEKLLIDELNLEEASSILQMIDDAIETLYDQLEAEVEAGQEIKSRMPELTEEKLEQDHTQTKAETALVKESYKDQQKAFEKRLEEIEKLMKQIREKLDRHVAYSLLMDEINQLETFIEDAKALHDTFKGHLQSLRKEELQARETLAELKTMLTDTVRQLHKSNGVPAEMKERAEKAQEMIHQVHEQLENLPLNMPAVNQQLKEASDTVRNVVDETEEM............................................................................................................................................................................................................................................................................. 492
32 -13.700PF00261.15; Q805C4_TAKRU/12-248; Tropomyosin  ali follow..  16  25........................................................................................................................................................................................................................................................................................................DSERELREKAEGEVAALNRRIQLVEEELDRAQERLAVALQKLEE--AEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEDRKYEEVARKLVILEGELERAEERAELSECKASDLEEELKNVTNNLKSLEAQAEKYSEKEDKYEEEIKILTDKLKEAETRAEFAERTVTKLEKSIDDLEEKLSSAKEENLGMHQVLDQT............................................................................................................................................................................................................................................................................. 230
33 -13.400PF13558.1; A3YC50_9GAMM/971-1061; Putative exonuclease SbcCD, C subunit  ali follow..  13  33.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GSGGEKQSPFYVAIASSLALSNPGRSAGLALLDEAFDKLDEENLKNAMDFMGD........................................................................................................................................................................................ 90
34 -13.400PF05701.6; Q9FWW5_ARATH/24-519; Plant protein of unknown function (DUF827 topsan)  ali follow..  10  34................................................................................................................ESVCDKETQLMLVHKEFMKIKQKLDNAESTRSRLDDLSKAKKTMEDLSNKLETVNKSKQSAIDTKETVQQREEQLEHDKCHGSPPHHHELDVAREQYISTT--VELDAAKQQLNKIRQSFDSAMDFKATALNQAAEAQRALQVNSAKVNELSKEISD---MKDAIHQLKLAAAQ--------NLQEHANIVKEKDDLRECYRTAVEEAEKKLLVLRKEYEPELSRTLEAKLLETTSEIEVLREEMKKAHESEMNTVKIITNELNEATMRLQEADDECSLRSLVNSLRMELEDLRREREELQKEAERLEIEETKKLEALKQESLKLEQMKTEAIEARNEAANMNRKIESLKKETEAAMIAAEEAEKRLELVIREVEEAKSAEEKVREEMKMI............................................................................................................................................................................................................................................................................. 414
35 -13.400PF14662; C9JGW3.1/157-349; Coiled-coil region of CCDC155  ali follow..  13  1...................................................................................................................................................................................................................................................................................................................QATADLLSSLEDLELSNRRLVGENAKL---------QRSMETAEEGSARLGEEILALRKQLHSTQQALQFAKA---MDEELEDLKTLARSLEEQNRSLLAQARQAEKEQQHLVAEMETLQEENGKLLAERDGVKKRSQELAMEKDTLKRQLFECEHLICQRDTILSERTRDVESLAQTLEEYRVTTQELRLEISRL............................................................................................................................................................................................................................................................................. 184
36 -13.400PF09730.4; Q3TBD4_MOUSE/9-723; Microtubule-associated protein Bicaudal-D  ali follow..  11  1......................................................................................GQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEIERQLEEALETLKTEREQKNNLRKELSHYMSINDSFYTSHLQVSLDGLKFSD----APPSPSLVSDLLSELHISEIQKLKQQLVQMEREKVGLLATLQDT---------QKQLEQARGTLSEQHEKVNRLTENLSALRRLQAGKERQTSLDNEKDRYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKISLLEKASHQDRELLAHLEKELKKVSDVAGETQGSLNVAQDELVTFSEELANL............................................................................................................................................................................................................................................................................. 457
37 -13.100PF03904.8; YP2A_STAAU/1-230; Domain of unknown function (DUF334 topsan)  ali follow..  2....................................................................................................................................................................................................................................................................................................................RKGQLIMSMKDIKNNKENPNTQMNSK----------------STGTPSSSTQNSLNNEELSELKRQNKLIVKYLA------EIQENQKIREKEQKEITSELKEATKDFRDKSLKIRNDFVDVLQEKLKHVDTEELKDILGRGIYKVREENDRMLQEVKRSHEHYQTRQKYLFTGIGAMLLVFMLFALIMTIGSDF............................................................................................................................................................................................................................................................................. 174
38 -13.100PF14817; B5X4P2.1/5-647; HAUS augmin-like complex subunit 5  ali follow..  80................................................................................................................AKRFELQEQIEELRVELNHLDSQINGTEAQLVTEE------ESINRSWEMVEENQCRELLLQAFKQRCMKERHSLSEDIHKISGHSQVLEQLSRRAEMKVVFGNETSNSSGDHLNPSGAEPKVLRNVRELCDERLQFFQSLQESELNMTSSTATHLTREQRTALFRHWLSAVE------DLLQCYPPNQVLSALQYLALGQEMTLEEMLASLDVARDVAALRFRYESNHLPDISKE---------EEELPPVKSLLQSAWEEVEQSLMELAQTRS--RIQLLQTQLHARKKEAQLELIGGESQTEALSQSVFKLEMQCGIQAAVRNSLRDQCVQMEQHARDRQEDLRNLRQNIMDFRQLGDVRQEQIRGLIKGNSIAKTELTRVHKEIGQF............................................................................................................................................................................................................................................................................. 450
39 -13.100PF09074.5; RE107_YEAST/19-214; Mer2  ali follow..  2..........................................................................................................................................................................................................................................................................................................................EHSLMITETSSPFRSIFSHSGKVANAGALEESDKQILEWAGKLELESMELRENSDKLIKVLNENSKTLCKSLN--KFNQLLEQDAATNGNVKTLIKDLASQIENQLDKVSTAMLSKGDEKKTKSDSSYRQVLVEEISRYNSKITRHVTNKQHETEKSMRCTQEMLFNVGSQLEDVHKVLLSLSKDMHSL............................................................................................................................................................................................................................................................................. 188
40 -13.000PF08614.6; A16L1_PONAB/13-207; Autophagy protein 16 (ATG16)  ali follow..  3......................................................................................................................................................................................................................................................................................................................RHISEQLRRRDRLQRQAFEEIIL------------QYNKLLEKSDLHSVLAQKLQAEKHDVPNRHEISPGHDGTDSQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQRKDREMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKLRKTTEENQELVTRWMA.............................................................................................................................................................................................................................................................................. 184
41 -13.000PF13555.1; Q0A6A1_ALHEH/19-80; P-loop containing region of AAA domain  ali follow..  22  8NWGTFHD---------RVWSLQPGGDNSLLTGDIGSGKSTLVDAITTLLVPAQRITYNKAAGA..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 61
42 -13.000PF07111.7; CCHCR_PANPA/27-782; Alpha helical coiled-coil rod protein (HCR)  ali follow..  11  331................................................................................................................DSVKQLKGQVASLQEKVTSQSQEQAILQSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEEAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVADVSLELQQLREERNRLD-LQLSARLIQQEVGR----QGEAERQQLSKVAQQLERELQQTQESLASLGLQLEVARQGQQESLTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAA-ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLCSASAPIAAAVPTRESIKGSLSVLLDDLQGLSEAISKEEAVCQGDNLDRCSSSNPQMS.............................................................................................................................................................................................................................................................................. 755
43 -12.900PF05276.9; Q4SIQ7_TETNG/16-252; SH3 domain-binding protein 5 (SH3BP5)  ali follow..  12  21........................................................................................................................................................................................................................................................................................................DDINRWESELEDGRQRFRAVLVEAMCKLDGLMKRIGRAVDDSKP--YWEARKVAKQAQIEAQKATQEFQRSVEILRAA-KETIALAEERLLEEDSRQFDSAWQEMLNHATQRVMEAEQSRTRSEAEHKKTAANYNSSISHMRQLEKKLKRSINKSRPYFELKGKYYLQLEHLKILVNERQAKLMSAKAEYRKALRNLESISEEIHA.............................................................................................................................................................................................................................................................................. 223
44 -12.900PF05335.8; Q8T4I3_DROME/75-260; Protein of unknown function (DUF745 topsan)  ali follow..  1..............................................................................................................................................................................................................................................................................................CGLSQKNAKSKASSIAIKAAQDAKAANDAQMAAGEAASLQVKQDLAEKA---------------VQAARAAEAALAGKQQIMEQLELEEKEAVAVVD------EVKNSLHSTQVNAESAMLAFSEAKIQLDQLKVLLAEATAQMTNIETFANGAQLEMDEKGQLLEAANRRVESISRQVVAARQDYDKTKKAAYKAACAAVEAKQKA....................................................................................................................................................................................................................................................................................... 186
45 -12.800PF04310.7; MUKB_ECOLI/1-227; MukB N-terminal  ali follow..  13  14NWNGFFA-----------RTFDLDELVTTLSGGNGAGKSTTMAAFVTALIPDLT.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 56
46 -12.700PF09728.4; Q5RIN4_DANRE/94-406; Myosin-like coiled-coil protein  ali follow..  11  1..........................................................................................................................KGLGKEAASLLQSLNKLGSPEEKVEMVLKKYSELVDEHRTEKKQLEQFQQRQGLLVKQRDQLQFEHSRAILARSKLETLCRELQRHNRTLKE-ESLQRLREDEMKRKEITTHFQSTLVDIQSQIEQHSNRNNKLCKENSEL--------------------------------AGKLKTIIEQYERREESLEKIFKHRDLQQKLSDAKLEEA------------NMLLTQAEEKHKREKEYLLKEAIDKTKKYCTLREQEL------QMKKQLVLYSQKFDDFQNTLAKSNEIYVTFKQEMDKMTKKMKKLEKESTTWKTRFESCNKALVEMIDERSEKGKEFELFTLKIDRLETLCRALQDE............................................................................................................................................................................................................................................................................................... 312
47 -12.700PF15070; Q5DTL1.1/404-1022; Putative golgin subfamily A member 2-like protein 5  ali follow..  5.............................................................................................................SLKQLQVERDQYAENLKGESAMWQQRVQQMAEQVHTLKEEKEHRERQVQELETSLAALRSQMEEPPPPEPPAGPSEAEEQLQGEVEQLHKELERLTGQLRAQVQDNESLSHLNREQEGRLLELEREAQRWSEQAEERKQILESMQSDRTTISRALSQ------------------------------------NRELKEQLAELQNGFVRLTNENMEITSALQSE----------------QHVKKELARKLGELQERLGELKETVELKSQEAQ------GLQEQRDQCLSHLQQYAAAYQQHLAAYEQLTSEKEAIHKQLLLQTQLMDQLQHEEVQGKMAAELARQELQEAQERLKATSQENQQLQAQLSLLVLPGEGDVDQEEEDEEVPQS.............................................................................................................................................................................................................................................................................. 339
48 -12.700PF15030; Q6ZRC1.1/1-273; Protein of unknown function (DUF4527 topsan)  ali follow..  3.........................................................................................................................................................................................................................................................................................................................................................RDSEAEVTEEDPRLRAQQLHHRVLTLQCQLRDQGAAHQASLD--EATRLQEELQAKLEELQKKQHEAKLAVTPLKAKIASLVRKCRERNRLITHLLQELHRHGLGNLLLSELAQNMLNDVALAEYTATFLAPGVPETSHHLDVKSEMTAALRAQTYL.............................................................................................................................................................................................................................................................................. 157
49 -12.700PF05879.7; RD3H2_ARATH/46-791; Root hair defective 3 GTP-binding protein (RHD3)  ali follow..  1..............................MGPQSSGKSTLLNHLFKTSFREMDAFAGRSQ------TKGIWMARCVGIEPFTIAMDLE--EKQSALFAIAVADIVLINMWCHDIGREQAANKPLLKTVFQVMLRLFSPRKTTLLFVIRDKTKTPIELLERALREDIQKIWDSVRKPEAHKNTPLNEFFNVMIVALSSYEEKEKQFEQEVAELRQRFFHSISPGGLAGDRRGVVPASGFSFSSQQIWKVIKENRDLDPAHKVMVATVRCEEIANEKLRDLATNESW-----GKKLSSILEKYFSEYDAEAIYFDEGVRKEKRLLDFVYPSYATMLGHLRSNALESFKIRLEQSLNQGEGFAKAVRDSQQSCLMVFDKGCEDAAVKQATWDASKIREKLCRDIDAHTFFARSLSELTANYEKRLTQALSEPVESLFEAGGKETWPSIRKLLKRETETAVTDFLDVVTGFELDHAKIDAMVQNLKNYSQSLVE--KKAREEAAKILIRMKDRFSTVFSHDKDSMPRVWTGKEDIRAITKDARAEALSLLSVMTAIRLDERPDN-----IESTLFSLTPVQCKSLWRQFKSETEYTVTQAISAQEAHKRNNNWL----MIVLGFN-EFMMLLKN............................................................................................................................................. 661
50 -12.600PF11172.3; A6B5A0_VIBPA/11-211; Protein of unknown function (DUF2959 topsan)  ali follow..  11  16...................................................................................................................................................................................................................................................................................................EQVGYHKRDIMVDRVEDAKESQQEAQEEFTSALEALSALTNFDGGELESV-----YNNINDKYEDSEKAAQDVRDRIAAIEDVSDALFEEWQGELDLYTSAKLRRSSEQKLRETKASYKTMLSAMKRAEKKMTPVLNTLRTLYLKHNLNASAIGSLQGEFSSLEKDIQFAIKQMNEAIAESDKFLQKLN.................................................................................................................................................................................................................................................................................................... 201
51 -12.500PF16043; A7S4W5.1/475-727; Domain of unknown function (DUF4795 topsan)  ali follow..  1.................................................................................................................................................................................................................................................................................................................MQNMKKTLSMQQEDFKKDMEKNKKAIDQLSRE-----LSLFRAARKAQDAEGFNAVHHVHSMVLELQTKHDKMMATTA------ELVNEYNRREKVLDELADSIDKLEQKKADKQDVNKNIDIKANKEDLE---SKVSMNQFDESFNLLDRGLNEALEKMGNQMTIEDALKETLMDLQSKLTLKLDRNE...................................................................................................................................................................................................................................................................................... 175
52 -12.400PF04849.8; Q4SVU4_TETNG/101-401; HAP1 N-terminal conserved region  ali follow..  11  88........................................................................................................................................................................................................................................................................................................KALSERNDLLEEQVEHIREEVSQLRHDLSMKDELLQFYTNAAEEFTSTPVRPADSNVSTPTFFPLDSLQKKLKDLEEENKSLRSEASHLET--ETISYEEKEQQLVHDCVKELRNSNLQITSLSEELARKSDDASRQQEEITHLLSQIVDLQKKVKLHALENEELTQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNL............................................................................................................................................................................................................................................................................. 297
53 -12.400PF05010.9; Q2NKK4_HUMAN/638-837; Transforming acidic coiled-coil-containing protein (TACC)  ali follow..  1...........................................................................................................................................................................................................................................................................................................QYSQKDLDAVVKATQEENRELRSRCEELHGKNLEL-----GKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEK.............................................................................................................................................................................................................................................................................. 200
54 -12.400PF05911.6; Q10P54_ORYSJ/79-939; Plant protein of unknown function (DUF869 topsan)  ali follow..  473.....................................................................................................QSRISSLLDSESPQNNAGNILDSIRNILKDIEDEADSSNDSKTHHGDMVEVADNGSLMKHSSSGSKHAMDQ-------------ELVNAILKIQDFVKSLDQEVSKFQGQSSDCDGLCDKIQQFSALVEKALSNENVLNDIVMTLSLILSGTSEIKFMMLKENTKEADNNNLDYVDKVTLLENKV-----------QLEPLKDSISGPCLPRSSSDPEIEGPTDSGCDVKTAVQICSSEEF-----EQLKSEKLNLEAELSKCNEVIEETKFRFKELEKSLE------ELTSKLVASEKSNSLAETQLKCMAESYKSLESRKAELENEIKVLQSKIEVLTAELDDERQNHQEDITRYRDLEEKIERYENERNSMEKEIAAAAEKLAECQETILILGRQLQSM............................................................................................................................................................................................................................................................................. 851
55 -12.400PF15358; D2H7U7.1/26-586; Testis-specific serine kinase substrate  ali follow..  115.......................................................................................VRAKDSITSLKEKTTRVNQHVQTLQSECSVLSENLERRRQEAEELEGYCSQLKENCRKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQRQLQDETPRRQEAELQELEQKLDAGLSRHGLGPTAQSPGCCGPPGSPNEPPRPRSMAPGGWGMGPRAGEGPIVSEQEMQKVSAGLEELRRVGQGGGAAREVSSLTARWHQ------EEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQAARGLQE----------------LRGRADELCTMVERSAVSVASLRSDLEGLGP---VKPILEELGRQFQSSRRGSDLSMNLDRPPQGSCGRCASQGPQLSTESLQQLLERALTPLVDEVKQRGLAPACPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEALRAKNLLLT.............................................................................................................................................................................................................................................................................. 504
56 -12.300PF14362.1; D3CY45_9ACTO/50-394; Domain of unknown function (DUF4407 topsan)  ali follow..  12  96................................................................................................................................................................................................................................................................................................VISTPLVLRIFEAEITTELSLMRSERDSEFLATTQTDERGMRIKAL-EAEQKTLQATIDTSTDTVDVSTDPDVARIQKLVDTKQQQYDAAEQAVICENEGTC-GSGKVGRGPAYAEKVALRDRYRDELSVLNGQLTTAQATAR---------SKATDTRGAAQNTAKGRLKTVETELTDLRTARTAAIANFRKENGKENGLLIRIEALDN-------------------------------------LTAHRPALGLAHRFLLVF----------ITAIE-PIGPAN..................................................................................................................................................................................................... 333
57 -12.100PF12795.2; Q3KJ67_PSEPF/35-273; Mechanosensitive ion channel porin domain  ali follow..  2..................................................................................................................................................................................................................................................................................................................SLDKLTDSKLPEADKKALQTVLQNTLNQLNNRRD--YEQKLIDLKQQLATAPKQTIENSRELTRLKASAVVPVAQRFPKENIQQLEQMLTERSTQQSDLQKALADANSLIITAQTRPERAQAEISSSQTRIQQINNILKTSAEQRDLLNAELAALNALIPLRRQELAGNNQLQDLGNSQHDLLSEKSDRLDREIQEL............................................................................................................................................................................................................................................................................. 204
58 -11.900PF15272; G0VHV5.1/200-405; Spindle pole body component BBP1, C-terminal  ali follow..  10  1...............................................................................................................................................................................................................................................................................................................DEYVEEYQELLDEICKNTGALHMLDKELRDKDEHYELQ-----QQSFKSKYENLRVDLIYQLRQTKKVSDKYFELLSKYQNLRK--LAYNLETSSDAEVEDLQLTVTNLRQQLQMAQQDRSDALFRYERIDSALRNSELQRKAYETRIEELERELFARDNNISNSRYPSYKDTTRSTSPYPYMNHRGGRFSLTSDELSST............................................................................................................................................................................................................................................................................. 197
59 -11.900PF13851.1; GAS8_HUMAN/220-420; Growth-arrest specific micro-tubule binding  ali follow..  11  1...........................................................................................................................................................................................................................................................................................................HTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERD---KQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDL................................................................................................................................................................................................................................................................................ 201
60 -11.900PF04163.7; KAR5_SCHPO/1-544; Tht1-like nuclear fusion protein  ali follow..  136.....................................................................................................................................................................................................................................................................................SHFHDVNHLCRLANLEMQKELSIEVNMNVTLVQKQFLEMVILHLRNFESVTDKMNQRIDKFDGKF----NSVIENSFKDINFRVNQEIMGLVELQNHQQEGMVQQKEILS--TIKQLKSEIFDINSFFANFIEESAGYSNSLIEKLNEKFTSENAIALSAIGKYTSEFSAFMEKRIKNLITTTEDSLQQSVQSNIDFVNSGFQPLYDLTIQLKEELQSLKRLSSEQQNLQHEQILQWKSDFLNVSKDHLKVLQQLRPLIDIVEKFMNVYFKGLSNIISS........................................................................................................................................................................................................................ 408
61 -11.900PF06818.10; Q4RYH9_TETNG/478-682; Fez1  ali follow..  2..................................................................................................................................................................................................................................................................................................................KWEVCQKSGEISLLKQQLKEVQGELAQRVGEIVS---RGQLRETRGELTNTQVLLQEAHGTTRTRTLELEVCENELQRKSEAELLREKAGRLEAELAHLKDALASQGPGNRQCQVFPEDQEQLLARAQEPSQNMSVKMDRMRAELSYEHQRAEQQMSSFEEERRIWQEEKDKVIRYQKQLQQNYVQMYRRNRELEQ.............................................................................................................................................................................................................................................................................. 201
62 -11.800PF13870.1; B4J5C0_DROGR/499-675; Domain of unknown function (DUF4201 topsan)  ali follow..  2...............................................................................................................................................................................................................................................................................................................SQKRNEISDDRLYLISRKHTLGRITDKITKL-EQINEDLCMDDFINIQNQVAALDKKIEERNNDLKKLRLNYHTELHLTQHREKALALDSKLDVAKLNLEIMQKKQDQLRECLYKAKLERSNIRKVHS--DLSFQGGLLSMPALMFDYDETVERVRAKQASVKELKETFKHITQRILE................................................................................................................................................................................................................................................................................................... 177
63 -11.700PF14915; E2RN06.1/24-306; CCDC144C protein coiled-coil region  ali follow..  11  51........................................................................................................................................................................................................................................................................................................TMLNSKLQDEKLNRERLEAKLQSYRARLATAIQDRDQSQASKRD-----LELAFQRAKDEWCHLQDKMNFEMSNLKDNNEVLSQQLS------EVESKFNALEIELQHTRDALREKTLALEHLQRNPKQTQGQKKEIEQKSQNEHGKVNKYIGKHESLEEKLSQLQSENMLLREQLDDAYSRVECKEKTIIDLKDQVQVIVRMVRVAGEKRNLLLREKNKELINKCKQIMERAFRYEDEKEERE........................................................................................................................................................................................................................................ 283
64 -11.700PF10481.4; CENPF_HUMAN/1-288; Cenp-F N-terminal domain  ali follow..  15  5......................................................................................................................................................................................................................................................................................................LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSL---------EAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQ------KISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQA..................................................................................................................................................................................................................................................................................... 190
65 -11.700PF04111.7; YDKA_SCHPO/121-497; Autophagy protein Apg6  ali follow..  13  3.....................................................................................................................................................................................................................................................................................................................................EIYNRIFDLLSSKTKVDHPLCVECAELLTEEMSKTLRALKEEKKMYFNYDNFLSSQTVHEENTAALDSEIDELMKQINEKEEKIEEISDETDKLQKLLRELDEEKEKVYAEEQEFYNNLNQFQIKKLSLERQYDCANLEFEHNSRKLEKLQKM...................................................................................................................................................................................................................................................................................................... 155
66 -11.700PF10473.4; Q9GKN4_CANFA/3-142; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1  ali follow..  10  2..............................................................................................................................................................................................................................................................................................................................................................EKKQLHVLEKLRESERKADALQDKIENLERELQ------MSEENQELVILDAENSKAEVETLKTQMELTTKSLKDLESDLVTVRFEKENLIKQLQDKQGQVSELDTLLSSFKGQLEEKEREKIEMKEESRAALEMLRTQLKELNE..................................................................................................................................................................................................................................................................................... 140
67 -11.700PF15233; G3QLD7.1/46-198; Synaptonemal complex central element protein 1  ali follow..  2...........................................................................................................................................................................................................................................................................................................................................................GSLEPRVEVLINRINEVQQAKKKANKDLGEARTICE------ALQKELDSLHGEKVHLKEILSKKQDTLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAREICA...................................................................................................................................................................................................................................................................................... 142
68 -11.600PF13476.1; C4P4D4_ARATH/25-232; AAA domain  ali follow..  11  6NFMCHSNLE-----------IEFGDWVNFITGQNGSGKSAILTALCVAFGCRARGTQRAATLK------DFIKTGCSYALVYVELKNQEIYGDTLIIERRISDSTSLTVLKDHQGRKISSRKEELRELVEHYNIDVENPCVIMSQDKSREFLHSGNDKDKFKFFYKATLLQQVDDILQSIGTKLNSANALLDEMEKTIKPIEKEINELLEKIK............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 208
69 -11.600PF10234.4; A7SE98_NEMVE/14-284; Clusterin-associated protein-1  ali follow..  12  64...........................................................................................................................................................................................................................................................................................................AHIKLNTKKLYGADGYAVKELLKVTSVLYNAMKS-----NVTDDEAEPSDVTSLTFDISSRISDLKASRQLASEITTRGAALYDLLGHEVELRDIRTRAIAKPLEVNELENGIKKSISLAQDDIRKTTQMLDNIASDEANLEAKIDKKKQELERNQKRLRSLESVRPAFMDEYEKLEEELKKVYETYMEKHRNLSYMEQLLDD.............................................................................................................................................................................................................................................................................. 261
70 -11.600PF06637.6; PLVAP_HUMAN/1-442; PV-1 protein (PLVAP)  ali follow..  10  11..............................YARAGGSRG-FVSLIQFL-----------------------------------LVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEV-EIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDS-----PRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARE-NSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQASRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSS............................................................................................................................................................................................................................................................................................... 441
71 -11.600PF10498.4; IFT57_XENTR/25-384; Intra-flagellar transport protein 57  ali follow..  153........................................................................................................................................................................................................................................................................................................EEDSDNDQEHFIDLNALSAQTQKLNTKESSKPEEILES-NTDAAEWILEVERVLPQLKVTIRTDNKDWRVHVDQMHQHRDGIDTSLKETKG--YLDKLHNEVAKALEKVSSREKYINNQLEQLVQEYRSVQAQLSEAKERYQQASGGVTERTRILAEITEELEKVKQEMEEKGSSMTKIKQALTKLKHEIVQMDIRTGVVEHTL................................................................................................................................................................................................................................................................................ 359
72 -11.600PF15397; G1REG6.1/105-362; Domain of unknown function (DUF4618 topsan)  ali follow..  16........................................................................................................................................................................................................................................................................................................NFLTKLNEELIETIQDMESSTTLNVRALLQQQDILATIINILEYSNKQELKSELQEWEEKKKCKMSYLEQQAEQLNAKIEKTQEEVNFLSTYMDKSVQIATLMRQLQQVKDSQQDELDDLSEMRRKVLESLSQKKKKKILSSVVAETQRPYEEALLQKMWESQDFLKCMQRFREFIDQFKENMPVLRAEVEELQAQTREPREVIFE.............................................................................................................................................................................................................................................................................. 232
73 -11.500PF12532.3; B3QEB7_RHOPT/422-613; Protein of unknown function (DUF3732 topsan)  ali follow..  10  1..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................ELISKLESEIEDLTVPPIN-----ERQELFTSALDEAIQDYISLTRDALGNYGNYSEKKLHLRKPRTASTENVGSSSNHMFLHLFLFLGIHERNNGIHVAPFLIIDQFSRPYDVAKVKLALELLNQFITTANTIGKD---------------QIIVFEH....................................................................................................................................................... 167
74 -11.500PF12240.3; B1AXE8_MOUSE/396-605; Angiomotin C terminal  ali follow..  11  1.....................................................................................................................................................................................................................................................................................................................YVDKVEKMQQALVQLQAACEKREQLEHRLRTRLERELESLRIQQRQGNSQPTNASEYNAAALMELLREKEERIL------ALEADMTKWEQKYLEENVMRHFALDAAATVAAQRDTTVISHSPNTSYDTALEARIQKEEEEILMANKRCLDMEGRIKTLHAQIIEKDAMIKVLQQRSRKEPSKTEQLSSM................................................................................................................................................................................................................................................................................. 184
75 -11.500PF06409.6; A6NCT9_HUMAN/1-331; Nuclear pore complex interacting protein (NPIP)  ali follow..  3..............................................................................................................................................................................................................................................................................................C--C---VINTLADHRHRGTDFGGSPWLLIITVFLRSYKFAISLCTSYLCVSFLKTIFPSQNGHDGSTDVQQRARRSNRRRQEGIKIVLEDIFT------LWRQVETKVRAKICKMKVTTKVNRH--DKINGKRKTAKEHLRKLSMKEREHGEKERQVSEAEENGKLDMKEIHTYMEMFQRAQALRRRAEDYYRCKITPSARK........................................................................................................................................................................................................................................................................................... 209

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Ye Y, Godzik A. Flexible structure alignment by chaining aligned fragment pairs allowing twists. Bioinformatics. 2003 Oct;19 Suppl 2:II246-II255.