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Query: PF13166.4; Q63PW4_BURPS/9-780; AAA domain, from PfamA30U

Results of FFAS03 search in PfamA30U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst SFGCFSDFAWNAEVRDHGNNVAKFKKMNVIYGRNYSGKTTLSRIIRSLETGSISPRYASPSFSITISGAVITNNNIPAQGHDIRVYNKDFVDEHLAFLRDEQGHISPFAVLGSKNKEIEVEIDKLEDELGSVENKTGLRHSYQEKKKAHADKKKAAQDAQDELDKKIFDKANKNPTGIKHNSLYKDANYDVRKLKLDIKTVQDKKIAPLDDADRSSKVKLLSEVALPDIEKRLSFNSSLPALAKSTVELITKKIKPSAPIQELLNDAILQNWVKSGIPLHEATRETCGFCGSPLPADLWKRLGDHFNQESQDLEKDLDSVLTKISNEKTRIKNVVTVDRKNFYSANQATFDNLKADLDDAINNHEKSLQSLEDELNARKKDIFTERSTIDVQDNTVSISQKVSLVNELIERNNKTTTSLEEDQKIARNELRLSEISQFTIDIDLAGEEKKIKALEDQITKAKDELDAVEAEGKKRVDRVKELRTQLRDEKRGAEQVNQYLGHFLGHGGLSLSAVEEANTATYRFQILRGDQAAYNLSEGECSLVAFCYFLAKLEDIETKGKKLIIYIDDPISSLDSNHIFFVFSLIENYITKPIEDANGKTILDGNGRPTYRYEQLFISTHNLEFLKYLKRLTKPAKDSESFLITRKQSSSAIGLMPTYLRNYITELNYLFGEIYCCSDANNANSHYHSFYNFGNNLRKFLESFLFFKYPFSISDRTDHDKRIKMFFHDGTNSQAFVERLTNEFSHLGEFIDRGAQPIDCAEIAAVAKFVLKLast
1 -158.000PF13166.4; Q63PW4_BURPS/9-780; AAA domain  ali  100  1SFGCFSDFAWNAEVRDHGNNVAKFKKMNVIYGRNYSGKTTLSRIIRSLETGSISPRYASPSFSITISGAVITNNNIPAQGHDIRVYNKDFVDEHLAFLRDEQGHISPFAVLGSKNKEIEVEIDKLEDELGSVENKTGLRHSYQEKKKAHADKKKAAQDAQDELDKKIFDKANKNPTGIKHNSLYKDANYDVRKLKLDIKTVQDKKIAPLDDADRSSKVKLLSEVALPDIEKRLSFNSSLPALAKSTVELITKKIKPSAPIQELLNDAILQNWVKSGIPLHEATRETCGFCGSPLPADLWKRLGDHFNQESQDLEKDLDSVLTKISNEKTRIKNVVTVDRKNFYSANQATFDNLKADLDDAINNHEKSLQSLEDELNARKKDIFTERSTIDVQDNTVSISQKVSLVNELIERNNKTTTSLEEDQKIARNELRLSEISQFTIDIDLAGEEKKIKALEDQITKAKDELDAVEAEGKKRVDRVKELRTQLRDEKRGAEQVNQYLGHFLGHGGLSLSAVEEANTATYRFQILRGDQAAYNLSEGECSLVAFCYFLAKLEDIETKGKKLIIYIDDPISSLDSNHIFFVFSLIENYITKPIEDANGKTILDGNGRPTYRYEQLFISTHNLEFLKYLKRLTKPAKDSESFLITRKQSSSAIGLMPTYLRNYITELNYLFGEIYCCSDANNANSHYHSFYNFGNNLRKFLESFLFFKYPFSISDRTDHDKRIKMFFHDGTNSQAFVERLTNEFSHLGEFIDRGAQPIDCAEIAAVAKFVLK 772
2 -13.700PF02463.17; SMC_BACSU/2-1172; RecF/RecN/SMC N terminal domain  ali follow..  11  621....................................GTVLITEDL----------------------KGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAKKKNNSLLGRSRELEDVTKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQVAEKNIN------------THLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQKQTQSSTKESLSNELTEL-----------------------------KIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSFL---------TSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRDQRIKLQHGLDTYERELKEMKRLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKRVKLIKLAIEEL-DEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLSGGERTAIALLFSILKVRPV------PFCVLDEVEAALDEANVFRFAQYLKKYSSDT---------------------QFIVITHR...................................................................................................................................................... 1149
3 -12.800PF13175.4; I1YS32_PREI7/1-378; AAA ATPase domain  ali follow..  13  10NFRSYRSVE-------------SFENLTAFIGRNDIGKSTILEALD-------------------------------------IFFNEGKGVVKLEANDLNTEAKGQD----EQYIEITVCFNDLPTEITIDSTYLTTLEDEFLLNEDKELEVIKRYPLKGLKEQVYLSAYHPSGQNCSD-----------------------------------------------------------------------LYTKKSSDLKKIIKDADILC-------------------NNSVNAIMRSAIWKHYDASQHRKLRELDLAKED---------------------------------------------KNIWEKIKEFLPQYSLFQSDRKNSDNDSEVQDPLKEATKEIISSSNLETQFNQIATEVTKKL------------------------REVANSTLSKLKEMNPDIAGLEVKIPEVKDLKWAELFKSVSIEG-----------------------------NDGIAMNKRGSGVRRLILLNFFRAKAEEKASRDNRTIYAIEEPETSQHNEHQKILIDALKNLANN---------------------RQIMLTTHSGNIV.................................................................................................................................................. 378
4 -11.800PF13304.4; A0ZCH2_NODSP/23-347; AAA domain, putative AbiEii toxin, Type IV TA system  ali follow..  12  185.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AELGSTGLGLQAVVKYIKE---KEERTFTRFTALMRRFENFQGVRYNEKISKLVWEFDFGRKTTVEEPDSVSDGFMKAAAISLLAS------LYRPPSLILLEEIENGVNPGNIQELMHWIWQMTSPTSDGYT---------------SQFIITSHSPSVLR................................................................................................................................................. 325
5 -11.500PF12128.6; Q8EAA0_SHEON/8-1195; Protein of unknown function (DUF3584 topsan)  ali follow..  10  21.............................ICGTNASGKTTLQRLVPVFYGEYPSRVVPSTRDSFER-----------PHDSSYIIYE-RFIAKGFELS----KSQNGDTILCHTMAELGRDLKRQGIATTNLLNTREYRAIIQNDRTLLSTGSNRSELRAYARQFALCDGEHSLRHIEKLAKAVHSKEGKMETVKSMIAAILEEDGVNPPSSRLNPQRVEAWIRESQLIQGFEVIRPEFEKLEQEFNQLLSAEMRLSSLSRGYRNDESLEADRLEIQQTLSKELNL----KLRMLDDEWKEVRDELNLDLSAAKGDVAKCEYELDAIEDQHGAFLDANIEQAHKLQTEKHQDIEAAYNARRSKIGEQLNRELEGLHSEQDKQREARD-KQREVARGDLDALEAQWRSQMDAGKASFSEQEYQFKLNAAELKLRVDGVTYTE-RIHRADEEQESCNAKVERLTSDERKLRAKRDQANEALRIASLRVNERQTALDELHHMLFP.............................................................................................................................................................................................................................................................................. 532
6 -10.800PF04582.10; Q9DPB5_9REOV/1-326; Reovirus sigma C capsid protein  ali follow..  1.............................................................................................................................................................................................................................................................................................................MAGLNPLQRREVVSLILSLTSSTTTNPGDLTAV---------YERLTNLEASTKSLRQSLSSIVSDLSDVSVDLQDTTRA------LDDAIATLKGLNTTVAALQNSVASLSSTVNGLTDISSAHSEAL--------------SFLRTTIDGNTVAISNLKGDVSTNGLNIADLQNRMKSLESSTSHGLSFSPPLSVADGVV............................................................................................................................................................................................................................................................................. 173
7 -10.800PF15324.4; H9GLI0_ANOCA/127-1404; Hedgehog signalling target  ali follow..  1...........................DIFISQYDAGKEAVRAVFKQRVQNAPVFKEVKVQLCSNKKDSPKSSHSEMDSAATIAAATAAAIASTLKVQSDFEAKVSSV-------SKILNKLQETDRRLQLAVERQSSLKAPTRERSPCHQRFGELEKQMHLFMEQRLRNLENFQQQ--------QMNIQSHLISSALNPGGLQAASTAASKETTKPTAGRSLASQTSPPQDLLAARAVHMQACSRPFGSHAVHRQKSPLNTPAPRRYAPVPVSRDAKISQKMSK------REPPVGEKENMHQPAYGTTVGGGKLLEQILNSQETPASQDTYSLKESSGNNAVLWPFERECRSSVQEPEPFCAFKSTNQNLNPVERTVQK---------AGDVLRDLGQLKREMHDILQDAKEWKSDMNKFMKTTAHPGEAIQAKDRLPQSQSSSSLLPSSEAFLPMPPPAENYTVAPTLRELQQLSKSSILQSTQASKSILRDAEKILRAV--------------------------QKNKKLLEENLEAIIALHAFIDGLTADRDVLEEIRITVDEWIKAISME................................................................................................................................................................................................... 510
8 -10.400PF04163.10; KAR5_SCHPO/1-544; Tht1-like nuclear fusion protein  ali follow..  113...............................................................................................................................................................................................................................................................VRGSQSECVSKLESTSWLS--TSHFHDVNHLCRLANLEMQKELSIEVNMNVTLVQKQFLEMVILHLRNFESVTDKMNQRI----DKFDGKFNSVIENSFKDINFRVNQEIMGLVELQNHQQEGMVQQKEILS--TIKQLKSEIFDINSFFANFIEESAGYSNSLIEKLNEKFTSENAIALSAIGKYTSEFSAFMEKRIKNLITTTEDSLQQSVQSNIDFVNSGFQPLYDLTIQLKEELQSLKRLSSEQ--------------QNLQHEQILQWKSDFLNVSKDHLKVLQQLRPLIDIVEKFMNVYFKGLSNIISSFAFI...................................................................................................................................................................................................... 412
9 -10.300PF10168.7; I3KZS6_ORENI/8-718; Nuclear pore component  ali follow..  537...................................................................................................................................................................................................................................................................................................SRATQVFREEYILKQDMAREEMQRRVKLLTGQKNKQLEELSLCREERKS--LREAAERLADKYEDAKYRQETIMNRVKKVLCSLQSQLPI---------LSNSEKEMKKELQTINDQLKHLDNCIRQVNMKMEYQKTQVDK----------DMPGTRARVSLNAPQKKVVQDVLKEQGQQIGDMMKQIKDIKNHFS............................................................................................................................................................................................................................................................................................. 711
10 -10.100PF13779.4; D7A9C0_STAND/55-942; Domain of unknown function (DUF4175 topsan)  ali follow..  524.................................................................................................................EDGDLSDVEKKLRDAQQALQNALENNASDDEIKRLTQELREAMQEFMQALAEEAQRNAQADSDQPMGPNTRMVRPQDLQKMLDRIEDMARNGARDAARQMLSELQNMLNGLQAGRQQQRRQGQNQMSQAMDQLGDMIRRQQQLRDRTFKQGREQGQQ--------------------GEQGQQGQQDQRFGDLKQSQEQLREQLRQLREKMQQAMRGRQQGQGEQGQQ--EQQGQNGQGQQGQQGEGQQGQGMPGEGGLGEAEQAMREAEQALGQGDGTGAVDAQSEALQALRKGAQQMAEAMQQQPGQGQGQEPGGPSGETAERNDPLGRPMRSRDYGDDVTVKVPDEIDMQRARRVLEELRRRFGEPERPRLE----LDYLERLLR............................................................................................................................................................................................................................................................................... 888
11 -9.780PF13558.4; B3PE30_CELJU/966-1055; Putative exonuclease SbcCD, C subunit  ali follow..  15  27.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SKRLGPGSGGEHRTPLYVIFGAALASRGSNAGGGIMLLDEAFEKMDAQNVRATADYLNA........................................................................................................................................................................................ 90
12 -9.650PF10186.7; B2WCB9_PYRTR/3-373; Vacuolar sorting 38 and autophagy-related subunit 14  ali follow..  13  1..............................................................................................................................................................................................................................................................................................CDICGRDGSLSQPLHCITCARAYLEHPRIELAKTLIDLDGVEKHVKAIINGSEDKAIQHVSLTDSKGGLLVDRQECTNNLNWQRTKAETAEIQER------LGNISDHAHQLRQQMEATRKLLEAKRAANAQRKSDLSSATYGI------ESRRANELDKVQQKVKRLDYNADKMHHDTIDLRMQLCTTAAKLAGLKMQRRKTRDGGVKEVFNIGPGSRLRIYDLR----------DMNDVAPDSLSASLAAVAQLLVRVAAYLG------PHSDYPQPTIFSPASS....................................................................................................................................................................................................... 268
13 -9.350PF16046.3; F7AMW1_ORNAN/4-306; FAM76 protein  ali follow..  93.........................................................................................................................................................................................................................................................................................GLPHGCEQCKQQCAFDRKDDRKK--TKEQRKHLSSSARAGQPEKEQFSRLSSSSSSSSSGGGSHYNSQKTLSTSSIQNEIPKKKPKFDAIVANGDSFSPDLALDSPGTDHFVIIAQLKEEVATLKKMLHQKDQMILEKEKKITELKADLQ-------------YQESQMRAKVNQMEKTHKDVTEQLQAKNRELLKQAAALSKGKK............................................................................................................................................................................................................................................................................................. 303

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Friedberg I, Godzik A. Functional differentiation of proteins: implications for structural genomics. Structure. 2007 Apr;15(4):405-15.