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PF09726
Query: PF09726.4; Q4SIM5_TETNG/2-648; Transmembrane protein, from PfamA26U

Results of FFAS03 search in PfamA26U
Master-slave alignment does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst TGRRQCHKRTFLYLKFLVVWVLVLLADFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVFFVCVAFTSDIICLLFIPVQWLFFAASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKNFHVDLCRPFAAHCIGYPVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQQMLQRPEKETEEVTKGISEVEPSVTSQNGAPPGKKSSTLQLPELEYREKAKDSTGKEGKKVGINNNSIIHLDSKLQEAEYIENYAGAKRLNNDLAGENTDSNTHSTSKEEMAGTGKNFKYNSGGGANISNSSPRNHSSSNGSVLSGSTSKNEKKQKGAGKAQKDPVENCIPNNQLGKPDALVRLEQDVKRLKTDLQANRQLESELRSQLSSLSSQDRSLRSELGPVRQDNELLQNKLHSAVQAKQKDKQTISQLEKRLKAEQEARTLAEKQLAEERKRKKMEEATAARAVALAAATRVESTDSLRSRIRDLETECKKLTMDMKLKEEQIRDLEGKCQELRKYKENEKDTEVLMSALSAMQEKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQIHQREQEIAELKQKIAEVMAVMPSLSYSSDGSNLSPVTPHYSSKFMDNSPSSLDPNASVYQPLLast
1 -102.000PF09726.4; Q4SIM5_TETNG/2-648; Transmembrane protein  ali  100  1TGRRQCHKRTFLYLKFLVVWVLVLLADFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVFFVCVAFTSDIICLLFIPVQWLFFAASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKNFHVDLCRPFAAHCIGYPVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQQMLQRPEKETEEVTKGISEVEPSVTSQNGAPPGKKSSTLQLPELEYREKAKDSTGKEGKKVGINNNSIIHLDSKLQEAEYIENYAGAKRLNNDLAGENTDSNTHSTSKEEMAGTGKNFKYNSGGGANISNSSPRNHSSSNGSVLSGSTSKNEKKQKGAGKAQKDPVENCIPNNQLGKPDALVRLEQDVKRLKTDLQANRQLESELRSQLSSLSSQDRSLRSELGPVRQDNELLQNKLHSAVQAKQKDKQTISQLEKRLKAEQEARTLAEKQLAEERKRKKMEEATAARAVALAAATRVESTDSLRSRIRDLETECKKLTMDMKLKEEQIRDLEGKCQELRKYKENEKDTEVLMSALSAMQEKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQIHQREQEIAELKQKIAEVMAVMPSLSYSSDGSNLSPVTPHYSSKFMDNSPSSLDPNASVYQPL 647
2 -16.500PF15921; G3SYM2.1/1-1109; Coiled-coil domain-containing protein 158  ali follow..  354..............................................................................................................................................................NSELTEARTERDQISQESGNLDDQLQKLLGDLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNMQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKEAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTCRSELNSDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVMGMQKQITAKRGQIDALQSKIQFLEEAMTNASKEKHFLKEEKNKLSQELNTVATEKNKMAGELDVLRSQERRLKEKVANMEVALDKFAECQDIIQRQEQESVRLKLQHTLDVKELQG. 845
3 -16.400PF04094.9; Q8S5S8_ORYSJ/246-1073; Protein of unknown function (DUF390 topsan)  ali follow..  11  379............................................................................................................................................................................................................................................................................TNTTVLDGLSAQMEVLQAERAELDAAWARVEEGRRSVEAMVEAGRKAHRRHTSELEARRRDL--AEIAREVEEERETALIATTVLNEARDDLRLQYGSRAAELEKKLDAARGVLDAAAARERRAAENEAASRQREEALEARATALEERARAKERDMADREAAVAIREATLAAHEAACAEEESALRLREDTLTERGRALEEAEAAAQRLADSLFLREAAREEQARRNLEGARAKRAALDQRVAELEARAKELDAR----AHSGGAAVGDGDLAARLAAAEHSIAELQGALDSSAGEVEALRLAGEVGPGMLRDAVSRLDRAGRQAGLWGGRCAKYAANQGGLAQRLSEMAGTLQRLPEELEETIKSSSR........... 740
4 -15.900PF00261.15; Q805C4_TAKRU/12-248; Tropomyosin  ali follow..  13  1....................................................................................................................................................................................................................................................................................................................................................................................RKIQTLQQQADDAEDRAQVLQRQLDSERELREKAEGEVAALNRRIQLVEEELDRAQERLAVALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKE-AKHIAEEADRKYEEVARKLVILEGELERAEERAELSECKASDLEEELKNVTNNKSLEAQAEKYSEKEDKYEEEIKILTDKLKEAETRAEFAERTVTKLEKSIDDLEEKLSSAKEENLGMHQVLDQTLLELNSL...................................... 237
5 -15.600PF13779.1; A9D7X3_9RHIZ/37-855; Domain of unknown function (DUF4175 topsan)  ali follow..  377..................................................................................................................................................................SETLETILPGRRFSNPLAAAVVEQRGVLALDAQNLPRVFDLHDALTIAPEETIPDLSLLQSVRGRLENARSDEDLHAAIDYMWGVALQLEDGNLSLAERRLRDAQNALAEALENGATDEEIAQLMDELREAMQEFLQELARQNQNNPASEMQQAMPENMLRQRDLDNMLDQIENLARSGARDQAQQMLQELQRMMNNLQAGRQQRQQQQGGPMRQQMDKLGELMRQQQQLMDETMRADRDRQSQSGEGRDRQEQGQNQPGQ----GQDQGQQGQGSQSLEEMLGALGRSQQELQDALGQLQRDLEGMGINPSEGFGEAGEAMGDAAGNLQQ--GQTGQALGDQGRALQALRQGAEDMMNQMMQAMGNQQGDAEGEGPDQNGNRSADDRDPLGRPRATTGPDFGSRVQV-EIDIQRAREILDAIRKRLGDQLSPEVEKRYLERLLD........................................ 819
6 -15.600PF04849.8; Q4SVU4_TETNG/101-401; HAP1 N-terminal conserved region  ali follow..  1.................................................................................................................................................................................................................................................................................................................................................EYICLPSHGGKAKEVEEEEMDEEQQIGRSSMTTKLLWLKFLRVLCADRVGQMTKTYSDIDAVTRLLEEKERDLELAARIGQSLLKKNKALSERNDLLEEQVEHIREEVSQLRHDLSMKDELLQFYTNAAEESEGESFT-STPVRPADSNVSTPTFFPLDSLQKKLKDLEEENKSLRSEASHLETETISYEE--KEQQLVHDCVKELRNSNLQITSLSEELARKSDDASRQQEEITHLLSQIVDLQKKVKLHALENEELTQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNK....... 300
7 -15.400PF01576.14; O44934_LOLPE/1067-1925; Myosin tail  ali follow..  362..............................................................................................................................................................AIDVERSSAHANNLEKKQRNFDKVVSEWQHKCNDLQAELENAQKEARSYSAELFRVRAQCEEVGDTVASLRRENKNLADEIHDLTDQLGEGGRNTHELEKARKHLALEKEELQAALEEAEGALEQEEAKVMRATLEISQIRQEIDRRLQEKEEEFDNTRRNHQRQASLEAEAKGKAEALRIKKKLEGDINELEIALDATNRGKAELEKNVKKYQGQIRELQSQVEEEQAQRDEAKEHYQMAERRCAAINGELEELRTILEQAERARKAAENELADASDRVNELQAQVSTVGSQKRKLEGDVTAMQSDLDELNNELKD-ADERAKHAMADATRLADELRQEQDHGLSVEKMRKSLESQVKELQVRLDESEAAKGGKKMIQKLESRVRELEAELDSEQRRHAETQKSMRKVDRRVKELSFQQEEDRKNYERMQELVDKLQNKIKTYKRQVEEAEEIAAINLAKFRKVQQELEDAEERADQSEGALQKLRA. 855
8 -15.300PF06008.9; P70570_RAT/237-496; Laminin Domain I  ali follow..  14  6......................................................................................................................................................................................................................................................................................................................................................................SVNTGSLEQIRHVEMQAKDLRNQLLGFRSAISSHGSQMDGLEKELSHLYQEFETLQEKAQVNSRKAQTLYNNIDTTIQNAKELDMKIKNILTNVHILLKQIARPGGEGMDLPVGDWSRESAEAQRMLR-----ELRGRDFKKHLQEAEAQKMEAQLLLNRIRTWLESHQV--ENNGLLKNIRDSLNDYEAKLQDLRSVLQEAAAQGKQATGLNHENEGVLGAIQRQMKEMDSLKKYLTEHLATADASLLQTNSLLQRMDTSQ........................... 260
9 -15.100PF15905; E9Q837.1/14-339; Hyaluronan mediated motility receptor N-terminal  ali follow..  13  6..................................................................................................................................................................................................................................................................................................................................PSPGAYDVKTSEATKGPVSFQKSQRFKNQRESQQNLNIDKDTTLLASAKKAKKSVSKKDSQKNDKDVKRLEKEIRALLQERGTQDKRIQDMESELEKTEAKLNAAVREKTSLSASNASLEKRLTELTRANELLKAKFSEDGHQKNMRALS--LELMKLRNKRETKMRSMMVKQEGMELKLQATQKDLTESKGKIVQLEGKLVSIEKEKI---DEKCETEKLLEYIQEISCASDQVEKCKVDIAQLEEDLKEKDREILSLKQSLEENITFSKQIEDLTVKCQLLETERDNLVSKDRERAETLSAEMQILTERLALERQEYEKLQQ. 324
10 -15.100PF12128.3; Q8EAA0_SHEON/1-1188; Protein of unknown function (DUF3584 topsan)  ali follow..  12  386.............................................................................................................................................................GEQLNRELEGLHSEQDKQREARDKQREVARGDLDALEAQWRSQMDAGKASFSEQEYQFKLNAAELKLRVDGVTYTEEEKLNLAIFDERIHRADEEQESCNAKVERLTSDERKLRAKRDQANEALRIASLRVNERQTALDELHHMLFPQSHTLLEFLRKEAQGWEQSLGKVIAPELLHRTDLHPSVTGESDTVFGVNLDLKAIDVPEYAASEQELRIRLSKAEEALQSAQELQAEAESQLVAINGELDKLSRELTFARTAYKNSRDDLRRLFDEKRSEQDKINKLAERKAFAQQRLTQLDGELKQLKHQHQLWLEEQKE---QALEARMEKQAYWQEVIGALDNQLGQIKATIDARRESAKAEQKACEELKSRGVDEDNILKLKQQIRELETKISRAEQRRSEVLRFDDWYQHTWLIRKPKLQTQLSDVKRAASEIDQLKAKTQEVKTRRQQLETERKASDAAQIEASENLTKLRAVMRKLAELKLPANN. 878
11 -15.000PF14915; E2RN06.1/24-306; CCDC144C protein coiled-coil region  ali follow..  10  2................................................................................................................................................................................................................................................................................................................................................................................RMLQDELAMLRLEIDTIRNQKQEKRYCEDTETEKEKNDSLQNAIKLNENTMLNSKLQDEKLNRERLEAKLQSYRARLATAIQDRDQSQASKRDLELAFQRAKDEWCDKMNFEMSNLKDNNEVLSQQLSEVESKFNALEIELQHTRDALREKTLALEHLQRNKQTQGQKKEIEQKSQNEHGKVNKYIGKHESLEEKLSQLQSENMLLREQLDDAYSRVECKEKTIIDLKDQVQVIVRMVRVGEKRNLLLREKNKELINKCKQIMERAFRYEDEKEERE.. 283
12 -14.900PF09728.4; Q5RIN4_DANRE/94-406; Myosin-like coiled-coil protein  ali follow..  11  1.............................................................................................................................................................................................................................................................................................................................................................................KGLGKEAASLLQSLNKLGSPEEKVEMVLKKYSELVDEHRTEKKQLEQFQQRQGLLVKQRDQLQFEHSRAILARSKLETLCRELQRHNRTLKEESLQRLREDEMKRKEITTHFQSTLVDIQSQIEQHSNRNNKLCKENSELAGKLKTIIEQYERREESLEKIREKEYLLKEAIDKTKKYCTLREQELQMKKQLVLYSQKFDDFQNTLAKSNEIYVTFKQEMDKMTKKMKKLEKESTTWKTRFESCNKALVEMIDERSEKGKEFELFTLKIDRLETLCRALQD. 311
13 -14.800PF10174.4; Q7Q0K7_ANOGA/59-838; RIM-binding protein of the cytomatrix active zone  ali follow..  17........................................................................................................................................................QEMERGQAGIQRIVSERDKAYAELEKIREELERTQATLGKSQLTQEKLQNSLDKAQNEIDHLQEKLDKSGGETRRLQLEKEKINYEFENIQSQLDKSLGQASRIQKEKEAAQMDLDRYRDKADKLQSSLARLQKERDVLSDELEKLKEKSESTQSTALKYQRERDAIQTELEVVKERWEKAHQVQMERDDATTEIDILKEKLDKALYASQKLIDEKDTSTKEFEKMLEKYDRAQNEIYRLQSRVDTAEADRNRLEVEAERSALAAAKAREDLRKIQEETTRLQEACDRAAMQLGRSKELEDKAKEDVDMIRERLDKCQTDLRRAQSEKDNRLTYELDRSHNLYTKQTASLDSAQEEIARYGLEIEKMRERYEKTAAELRRLQENESFSREARRMKDENDRLREKYDKVIVELENFRGKSQYEQETFDKMKEKFETRENEFQTMELKLHETSLQLDLARAEVTKLISNQDKQRADAERAHIEYEKIRDKHEKLIK. 520
14 -14.700PF15934; B4NYC9.1/468-698; Yuri gagarin  ali follow..  10  1..................................................................................................................................................................................................................................................................................................................................................................................VLREIADLICKLGSMEFSYNEIYDESSRENPFCTTIAELFELRSQQEQKHTALNEHLACQIQGLEDNLKDRDNQINQLQSMIKSYSDLTENSRKGEIHDLKLKNCDLSRQLRELSSLMRNQEDQRVELCSKYENLMTNFEDQCQELKGAKRKVQSLQSRDQVEKLQDELRTERKMLREEVIALKEKEAVSAGRERALQEQQKIGHLELEKMRNHIRNMQDHLQLDDIR................................................. 230
15 -14.700PF10168.4; Q707M9_XENLA/4-726; Nuclear pore component  ali follow..  10  467.........................................................................................................................................................................................................................................................................................................................................................................CDFECIARPLLTTIRPPSPPLLCSQIDKSSTEILPHVLADVKGPFEIHIRGILRRNSANPLLLNSSSKDSSPPP------EECLQLLSRATQVFREEYLLKQDLAKEEIQRRVKLLIAQKEKQLEDVRYCREERKSLTETAEHLAEKFEEAKERQEDLINRLKRILR--SFHTQLPVLSESERDMKKELQATTEQLQHLGNCINQVKRKMSYQEKQMEKGKSPRKSSDYQKKNIKTVLKEHGEHIQEMVKQINNIRNHVN.......................... 722
16 -14.400PF07888.6; Q7ZTT2_DANRE/1-545; Calcium binding and coiled-coil domain (CALCOCO1) like  ali follow..  11  98.....................................................................................................................................................................................................................................................................................RGDVCAISSQFTFAAPRPLDELVTLEKSGEGEEDGDDLLLVVPKALILQNLLEGCQRELHELHKKFEAVNGDVENERQRWKTDRDEFEILRSDMRSQIEQLKTNLRHSTEKTEELERKHKEAQSSSESMSAEFNALLAERAENQQRIKELEQDSATLTQQKQDIEAELERMKERVKKMTIQRRDEETERIDLQLENEQMHADL-RTLQERLEASERSTGALRRDLSELGSLQSHSHAELHQVRLQSAQMSL--QLSQANLALREGQSTWAQERETLRQSAELDKDRVQKLSRELQKKEEWLQEERSEREKLEVELGIEKDCNRELRASLRALQKEQEQHQLEKQELLDHIHVLELRLDTETDAKWAEAA. 463
17 -14.300PF05557.8; Q9W6G9_XENLA/2-716; Mitotic checkpoint protein  ali follow..  10  98............................................................................................................................................................READRNQGLHTRIKALEEKENEFQNKLQEQNEMIKSYKKTIEAQSKKLLEKEDKLSESNENISVLKGKASELQWKNQEMQIKTQETEKQELTEQLEIHRKKLQESNEKMQALHELQAQNADNEQKIKSLEQKLSAQEQDAAIVKSMKSDLTKLPKLERELQQLRDENAYHREMKENNALLKEEVEGLRRAAERFNKMKEDLVGSEIEKEQLVKKLK-LWENLEQSTGLNIRTPDDFSRQIMAVQQRELKLKEENMTIQISARMLETSRQQLQEELLKVQSGFLEEKKRREHQEALVRRLQKRVLLLTKERDGMRAILDSYDSELTP--TEHSPQLSRRLKEAEDILQKVQDHNAEMETQLSEALEDAGIQKQ------KSELLTAELKVLKSQMGSSDQNISFTNEAMSALRLKIEELEAERGRLEEENKILEMRLESLNLQGCYDPSRTKVIHLSLNPASKAKQQRTDTVRHLQEECDKLREIVRILEG. 580
18 -14.300PF05483.7; SYCP1_RAT/28-813; Synaptonemal complex protein 1 (SCP-1)  ali follow..  11  49..............................................................................................................................................................MLEQVANSGSCHYQEGVNDSDFENSEPMSRLYSKLYKEAEKIKKWKVSIESELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHWCNLLKETCARSAEKTSKYEYEREETRQVYVDLNNNIEKMILAFEELRVQAENARLEMHFKLKE--DHEKIQHLEEEYQKEVNNKENQVSLLLIQSTEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELNEKKDHLTSELEDIKMSMQRSMSTQKTLEEDLQIATKTIYQLTEEKEAQMEELNKAKTTHSLVVTELKATTCTLEELLRTEQQRLENNEDQLKLITMELQKKSSELEEMTKFKNNKEVELEELKTILAEDQKLLDEKKQVEKLAEELQGKEQELTFLLQTREKEIHDLEVQVTVTKTSEEHYLKQVEEMKTELEKEKLKNIELTANSDMLLLENKKLVQEASDMVLELKKHQEDIINCKKQEERMLK. 534
19 -14.100PF15964; Q5PQY1.1/1-716; Centrosomal colon cancer autoantigen protein family  ali follow..  202........................................................................................................................................................KRPFSHGDAETGKAASTGDADKWRLELERLKLTYEAKTDLLESQLKLLRKDLVEYQKTCEDLKERLKHKESLVTASASSR-VGGLCLKCAQHEAVLSQTHNNVHIQTIETLTKERDDLMSVLVSVRSSLAEAQERETSAYKQVKHAVQMTEEANFEKTKALIQCEQLRSELERQTDRLEKASQQEKRALEKEMIKKEVTREREEAEAKMLILSQNIAKLEAEIEKITREKTSAVSQLEEVQNQLASQEMDVTKVCGEMREHKEYKAKSQKDLEMKDQEIEKLRLELSESTQQVEQEQQKAARARQECLQVTELLGESERQLHLTRLEKDSIQQSFSNEAKAQALQALQREQELTQKIQQMETQHDKTDSEQYLLLTSQNTFLTKEECCILAKKLEKVSLKSRSEIVQLSQEKRYLCDKLEKLQKRNDELEDQCVQHGRVHETMKERLRQLDKHGQATAQQLVQLLNKQNQLLLERQNLSEEVDQLRAQLPSMPQ. 713
20 -14.100PF09738.4; LRRF2_BOVIN/31-326; Double stranded RNA binding protein (DUF2051 topsan)  ali follow..  10  2.................................................................................................................................................................................................................................................................................................................................................................EARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRVSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEE-QEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEKHGLVIPDGTPNGDVHQEPAVGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSGRDGTAGDLAELQNGSDLQLIEMQRDANRQISEYKKLSKAEQDITTL 296
21 -13.900PF15070; Q5DTL1.1/404-1022; Putative golgin subfamily A member 2-like protein 5  ali follow..  11  4..................................................................................................................................................................ESLKQLQVERDQYAENLKGESAMWQQRVQQMAEQVHTLKEEKEHRERQVQELETSLAALRSQMEEPPPPEPPAGPSEAEEQLQGEVEQLHKELERLTGQLRAQVQDNESLSHREQEGRLLELEREAQRWSEQAEERKQILESMQSDRTTISRALSQNRELKEQLAELQNGFVRLTNENMEITSALQSEQHVKKELARKLGELQERLGELKETVELKSQEAQGLQEQRDQCLSHLQQYAAAYQQHLAAYEQLTSEKEAIHKQLLLQTQLMDQLQHEEVQGKMAAELARQELQEAQERLKATSQENQQLQAQLSLLVLPGEDSREAMVAFFNAAIARAEEEQARLRVQLKEQKARCRSLSHLAAPVQSKLEKEAVVSASEESNQALHVAMEKLQSRFLEVMQEKVELKERVEELEHCCIQLSGETDTIGEYIALYQNQRAVLKARHLEKEEYISRLAQDKEEMKVKLLELQELVLRLVNERNEWQG. 518
22 -13.900PF05667.6; CCD22_AEDAE/1-554; Protein of unknown function (DUF812 topsan)  ali follow..  190..................................................................................................................................................................................................................................................................................AEVKEFWSRRNLDCLDEGSLVPSLIAANDGAIKTNAKGAIDEVDRQVKLPAINEKLLQYYSKGGTKHRLAEPSGAAASSGTTEKVVLNNITVETKPGKTPLESLQEEIDALQQEIVQHSEEGVQLESSRKETDESIEEYRKTIVRLKEEKERTHILLEDPEVNVKKLEAIIAAGGERMKKLQDQWDAHRIPLVDTLEAYRLKNSDKLSKSQQVLDQIE----STRQKCEEVVIDLQTKGAMYARLQKEFEKLNKTVSRTSRILEIIGNIRKQKNGIDQILQDTRSLQKEINNITGQLDRQFTVTDDLIFRNAKKDEHSKRAYKLLVTLHSDCEELIKLVQETGAIKREVRDLEDQIENEKGR........... 553
23 -13.600PF05622.7; HOOK3_HUMAN/5-718; HOOK protein  ali follow..  12  151........................................................................................................................................................QELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEITPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAE---DSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKS. 652
24 -13.600PF05276.9; Q4SIQ7_TETNG/16-252; SH3 domain-binding protein 5 (SH3BP5)  ali follow..  11  1..........................................................................................................................................................................................................................................................................................................................................................................EEEEVDPRIQGELEKLNQSTDDINRWESELEDGRQRFRAVLVEAMCKLDGLMKRIGRAVDDSKPYWEARKVAKQAQIEAQKATQEFQRSVEILRAAKETIALAEERLLEEDSRQFD---SAWQEMLNHATQRVMEAEQSRTRSEAEHKKTAANYNSSISHMRQLEK------KLKRSINKSRPYFELKGKYYLQLEHLKILVNERQAKLMSAKAEYRKALRNLESISEEIHAQRRSVAMGTRE.......................................... 234
25 -13.500PF09787.4; A7USX6_ANOGA/12-516; Golgin subfamily A member 5  ali follow..  14  62............................................................................................................................................................................................................................................................................................NASEASSRRSSLNSKKEGTVIDMSEAVAENASYSKPEPSYSIEQELAAIKIVLAEIKAERDELKSELDSTLSQQLSNGETESKLLDLEVLCQNLSEEKMALAGKLLSLEEANGKYVKSISELESTIAKHIQSEQELNSKLDMARLETENALTELQQYRVRAHATLQLKEKTIEQLKEQMSGSGRTDSSTDSKHSNAEQILQIELEQTRQEKANLAEELTSLNDRMKQREAQWMNAEEKLRV--TVHALEQNVQRLQQQILLDADKFSVLEDDFKLKQREREDLIKQRTSFTLRLHEKESENSKLRNKIHDQEDRLASLTQSLVQKQTALETVTVERNALRIQLEKLENQYRNTASQVRQQRA. 435
26 -13.500PF09755.4; A0AUQ3_DANRE/3-319; Uncharacterized conserved protein H4 (DUF2046 topsan)  ali follow..  11  4..................................................................................................................................................................................................................................................................................................................................................................ASESDTDGATPHCSSSSSSSILISSFRLEELSNRLASLQQENKVLKIELETFKLKCKALQEENRDLRKASVTIQARAEQEEEFINTLFKKIQALQKEKETLAVNYEKEEEFLTNESRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKKLENDTISKQLTLEQLRREKIDLENTLEQEQEVNRLWKRMDKLEAEKRILQEKLDQPVSAPPSPRDTISMEIDSPENMMRHIRFLKSEVERLKKNLRTSELQHTEYIEEERHMREENIRLQRKLQREVERREALCRQLSESES. 303
27 -13.400PF08580.5; Q6FY01_CANGA/41-592; Yeast cortical protein KAR9  ali follow..  1............................................................................................................................................................................................................................................................................................................................SSIEDLCDVLEWITTQMNRILEIFPQIIDSTGIEVSSLLEYLDWLQERKELLFELVNDINSIGPFLSDILEEANLNTDPNKSLDEHEMHLIDLIERCSTLRDDLDPWLNKLRKLLDATLEFKEISNDHMDGLDKVVSENIQSCFDIQEERFTSPVRHAPTLEQIVDLLKQNSDSNAISVPTFNKQEKLISERFLELRRSVPAIEKSLTDILPNRFARRDMTNIDSLAEFLRDKYKVLMKKYEFMSSEISELNAELIDKRILFVNLNHEINFILDDYEKLKKKLNSVEEIVQIREKMSHQMTQKSLTIERTFKVIFKAQEFSLLDAGIASKT 343
28 -13.300PF07902.6; Q1CPP5_STRPB/1-621; gp58-like protein  ali follow..  10...............................................................................................................................................................................................................................................................................................................DESNLTIGSDGRAYYTFKADGDTKSVKLANNKCIGTTRFNQLMIERGGKPTNYVAPVVVEGSGESTGLFKNLEGALSQLKELNLELTDTVNS-AKIKLTTNGMLREYHRDNITTEIVESANGIATRISEDTDKKLALINETVSGIRRDYQDADRQLSSTYQAKATMANDKNDLKAVIQATAQGLSQKYDDEIQQLSAKITTTSSGTEAYESKLADLRAEFTRSHQGMRTVLE-SRISGLQSTQQSTAYQISQEIKNREGAVSRVQQDLASYQRRLQDTEKNYSSLTQTVRGLQSTVSAPNRGLESRVTQLAGLIEQKVTRGEMESYIRGAGDSIMLAIKG.... 356
29 -13.300PF15358; D2H7U7.1/26-586; Testis-specific serine kinase substrate  ali follow..  11  99..................................................................................................................................................................................................................................................................................................................................................DDPDITEILSGVNSGLVRAKDSITSLKEKTTRVNQHVQTLQSECSVLSENLERRRQEAEELEGYCSQLKENCRKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQRQLQDETPRRQEAELQELEQKLDAGLSRHGLGPTAQSPGCCGPPGSPNEPPRPRSMAPGGWGMGPRAGEGPIVSEQEMQKVSAGLEELRRVGQGGGAAREVSSLTARWHQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQAARGLQELRGRADELCTMVERSAVSVASLRSDLEGLGPVKPILEELGRQFQSSRRGSD.. 405
30 -13.100PF15254; G1T8F1.1/39-892; Coiled-coil domain-containing protein 14  ali follow..  241..............................................................................................................................................................QQGVPKEADLLKCFQTYMSLFQSHGKETHPDNQTYQSPTRSQQAFLASSEDKDAREQIGESTSEGKDLNIHKQDAKMVKDVQKAKNVNQTAEKVTTIKYFLGELKALVAEQEDSEIQRLITEVEACVSEQVEIALAMQPLRSENAHLRSRQLRILNQRLREQEKTKKTTGSVECNLELFSLQSLNMSLQSQLQESLKNQELLQSKNEELLKVIENQKDENKKYTSIFKEKDQTILENKQQFDIEITKIKIELEEALVDVKSSKFKLDTAEKENQILGITLRQRDAEVARLRELTRTLQNSMAKLLSDLSVDSARCKSGNNLTKSLLNIYDRQLQHDPAPAHTSIMSYLNKLETNHSVAHLEPLSTIKNEETTEPDRPYENVLPSSKQDSDAENETLTVIEDECNLDSTVYIPFVRSTSKMNSPLSKRLSPQPQMSVAITQLVGNSGLVSETEKKLCAHAVTCSSRQEVEDAHEKLSRTADTEDKQLLK. 761
31 -13.000PF16043; A7S4W5.1/475-727; Domain of unknown function (DUF4795 topsan)  ali follow..  2............................................................................................................................................................................................................................................................................................................................................................................QNMKKTLSMQQEDFKKDMEKNKKAIDQLSRELSLFRAARKAQDAEGFNAVHHVHSMVLELQTKHDKMMATTAELVNEYNRREKVLDELADSIDKLEQKKADKQDVNKNIDIKANKEDLESKVSMNQFDESFNLLDRGLNEALEKMGNQMTIEDALKETLMDLQSKLTLKLDRNELDNLRAQLESRIKEVQVTRTVIQVKPEDGEPAGFRRNITEK.................................................................... 216
32 -13.000PF07111.7; CCHCR_PANPA/27-782; Alpha helical coiled-coil rod protein (HCR)  ali follow..  56............................................................................................................................................................EGSQALSQQAEVIARQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKA--EGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLQATVELLQVRVQSLTHILALQEEEREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT-ASAEEQLRLVVNAVSSSQIWLETTMAKVEEAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVADVSLELQQLREERNRLDAELQLSARLIQEVGRAREQGEAERQQLSKVAQQLERELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQE. 569
33 -12.800PF10481.4; CENPF_HUMAN/1-288; Cenp-F N-terminal domain  ali follow..  11  2...............................................................................................................................................................................................................................................................................................................................................SWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQ................................. 288
34 -12.800PF09789.4; Q16UI1_AEDAE/24-343; Uncharacterized coiled-coil protein (DUF2353 topsan)  ali follow..  14  1.....................................................................................................................................................................................................................................................................................................................................................................HRKLQSKVEALKIMRNELEKYRSERDQFKLMAETLQMRYSAMKGHSSAVSLLVNQTRERNISLSTEVEALRQRVHELEGDIDVLRTKNFDLQAAFNKMKSTEETKLRDRKGIVDEEKSKLIAQMETLKKKNAQLQYDVRSLLDEKEDVVMERDAYKCKAHRLNHELSVMLKGDQSQQDVDGLILENKYQQEKITNLENELELSRQSATKYKNMLDTKRKKGIIKLGTNNGTVEELPLKAATISELKSLCLALLDNVNDKSLALSHQKKTNKLLAAKITELEQRILAL... 320
35 -12.700PF06818.10; Q4RYH9_TETNG/478-682; Fez1  ali follow..  11  2...................................................................................................................................................................................................................................................................................................................................................................................KWEVCQKSGEISLLKQQLKEVQGELAQRVGEIVSLRGQLRETRGELTNTQVLLQEAHGTTRTRTLELEVCENELQRRKSEAELLREKA-----------------------------GRLEAELAHLKDALASQGPGNRQCQVFPEDQEQLLAR-AQEPSGGEVLQNMSVKMDRMRAELSYEHQRAEQQMSSFEEERRIWQEEKDKVIRYQKQLQQNYVQMYRRNRELEQLLQE.......................................... 205
36 -12.700PF15619; E9Q424.1/143-336; Ciliary protein causing Leber congenital amaurosis disease  ali follow..  13  4...................................................................................................................................................................................................................................................................................................................................................................................HRILSARLHKIKELKNELADVHRKLEASAIENQFLKQLQLRHLKAIGKYVNSQNNLPQITAKHQNEVKNLRQLLRKSQEKERAVSRKLRETDGELLRTKDVLQALQRLSEDKNLAEREELTDRLTDLTAKMEANDKKIQNLEKQLRLNNRSYS--RQLAKENRKTLAAQTATKTLQAEVRQLQQKLKEKDRE.................................................................................... 193
37 -12.600PF08614.6; A16L1_PONAB/13-207; Autophagy protein 16 (ATG16)  ali follow..  10  3....................................................................................................................................................................................................................................................................................................................................................................................................................................RHISEQLRRRDRLQRQAFEEIILQYNKLLEKSDLHSVLAQKLQAEKHDVPNRHEISPGHDGTWNDSQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQRKDREQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKLRKTTEENQELVTRWMAEKAQEANRLNA................................... 195
38 -12.500PF14662; C9JGW3.1/157-349; Coiled-coil region of CCDC155  ali follow..  16  1..................................................................................................................................................................................................................................................................................................................................................................................................QATADLLSSLEDLELSNRRLVGENAKLQRSMETAEEGSARLGEEILALRKQLHSTQQALQFAKAMDEELED-------------------LKTLARSLEEQNRSLLAQARQAEKEQQHLVAEMETLQEENGKLLAERDGVKK------RSQELAMEKDTLKRQLFECEHLICQRDTILSERTRDVESLAQTLEEYRVTTQELRLEISRLEEQLSQTYE........................................... 193
39 -12.500PF02463.14; SMC_BACSU/2-1172; RecF/RecN/SMC N terminal domain  ali follow..  13  1............FLKRLDVIGFKSFAE--ISVDFVVVGP-WVLGEQSARSLRGGKM------------EDII-----------FAGSD---------SRKRLNLAEVTLTL---FHEVSVRLKDIIDLFMD----------AFSIISQG-DRRSIFEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKIQALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETVLKEELSKQEAVFETLQAEVKQLRAQVKEKQQASLHNENVEEKIEQLKSDYFELLNSQASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHSQVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDKKNNSLLGRSRELEDVTKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETEGLRLKQQDVKGQLYELQVAEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQKQTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKK. 837
40 -12.500PF12795.2; Q3KJ67_PSEPF/35-273; Mechanosensitive ion channel porin domain  ali follow..  12  1...............................................................................................................................................................................................................................................................................................................................................ASLDKLTDSKLPEADKKALQTVLQNTLNQLNNRRDYEQKLIDLKQQLATAPKQTIENSRELTRLKASAVVPVAQRFP-KENIQQLEQMLTERSTQQSDLQKALADANSLIITAQTRPERAQAEISSSQTRIQQINNILKTGKDAGKTVSAEQRDLLNAELAALNALIPLRRQELAGNNQLQDLGNSQHDLLSE------KSDRLDREIQELQTLINQKRLTLSQETVTQQSIEAQKSGSSALLAT................................................................... 238
41 -12.400PF15397; G1REG6.1/105-362; Domain of unknown function (DUF4618 topsan)  ali follow..  11  1......................................................................................................................................................................................................................................................................................................................................................................................LRNGRTALRELQSHENFLTKLNEELIETIQDMESSTTLNVRALLQQQDILATIINILEYSKKRLQELKSELQEWEEKKKCKMSYLEQQAEQLNAKIEKTQEEVNFLSTYMDHEYSVKSVQIATLMRQLQQVKDS---QQDELDDLSEMRRKVLESLSNKIQKKKKKILSSVVAETQRPYEEALLQKMWESQDFLKCMQRFREFIDQFKENMPVLRAEVEELQAQTREPREVIFEDVLLRRPKCTPDMDVILNIPVEE................ 255
42 -12.400PF04582.7; Q9DPB5_9REOV/1-326; Reovirus sigma C capsid protein  ali follow..  10  1................................................................................................................................................................................................................................................................................................................................................................MAGLNPLQRREVVSLILSLTSSTTTNPGDLTAVYERLTNLEASTKSLRQSLSSIVSDLSDVSVDLQDTTRALDDAIATLKGLNTTVAALQNSVASLSSTVNGLTDISSAHSEALSFLRTTIDG-NTVAISNLKGDVSTNGLNIADLQNRMKSLESSTSHGLSFSPPLSVADGVVSLDMDPYFCSQRVSLTSYSAEAKLMQFQWMAKGTSGSSDVIDMTVHGRRTDYMMSSTGGLTVTSNAVSLTFSLDYITNMPSDLSRLIPSVGFQAAS......................... 273
43 -12.200PF05701.6; Q9FWW5_ARATH/24-519; Plant protein of unknown function (DUF827 topsan)  ali follow..  5.....................................................................................................................................................................QSVKAAVSLFGEVAVSKQRSTPRRSRLSSESVCDKETQLMLVHKEFMKIKQKLDNAESTRSRALDDLSKAKKTMEDLSNKLETVNKSKQSAIDTKETVQQREEQLEHDKCHGSPPHHHELDVAREQYISTTVELDAAKQQLNKIRQSFDSAMDFKATALNQAAEAQRSAKVNELSKEISDMKDAIHQLKLAAAQNLQEHANIVKEKDDLRECYRTAVEEAEKKLLVLRKEYEPSRTLEAKLLETTSEIEVLREEMKKAHESEMNTVKIITNELNEATMRLQEAADDECSLRSLVNSLRMELEDLRREREELQQKEAERLEIEETKKLEALKQESLKLEQMKTEAIEARNEAANMNRKIESLKKEEAAMIAAEEAEKRLELVIREVEEAKSAEEKVREEMKMISQKQESKKQDEESSGSKIKITIQEFESLKRGAGEIEKKLATIAAELEEINKRRAEADNKLEANLKAIEEMKQATELAQ.. 496
44 -12.100PF10190.4; Q4RZH2_TETNG/25-129; Putative transmembrane protein 170  ali follow..  13  1.....LSDFSEMW-YGVFLWAVVSSLVFHI-------------PAVLLSLATLRARFMPIAIFLMGIVGPLCVLTSAAIAGVYKAAGKRMLEALVF----GVGQSFFVLVISFLRILATL............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 105
45 -12.000PF03904.8; YP2A_STAAU/1-230; Domain of unknown function (DUF334 topsan)  ali follow..  10  2..............................................................................................................................................................................................................................................................................................................................................................................RKGQLIMSMKDIKNNKENPNTQMNSKSTGTPSSSTQNSLNNEELSELKRQNKLIVKYLAEIQENQKIREKEQKEITSELKEATKDFRDKSLKIRNDFVDVLQEKLKHVD-TEELKDILGRGIYKVREENDRMLQEVKRSHEHYQTRQKYLFTGIGAMLLVFMLFALIMTIGSDFMSFLHVDTLQNAIAGKLKASE...................................................................................... 195
46 -12.000PF15272; G0VHV5.1/200-405; Spindle pole body component BBP1, C-terminal  ali follow..  1............................................................................................................................................................................................................................................................................................................................................................................................................DEYVEEYQELLDEICKNTGALHMLDKELRDKDEHYELQQQSFKSKYENLRVDLIYQLRQTKKVSDKYFELLSKYQNLRKLAYNLETSSDAEVEDLQLTVTNLRQQLQMAQQDRSDALFRYERIDSALRNSEL--QRKKDKIAYETRIEELERELFARDNNISNSRYPSYKDTTRSTSPYPYMNHRGGRFSLTSDELSSTDTNELKYQ............................................ 205
47 -12.000PF05911.6; Q10P54_ORYSJ/79-939; Plant protein of unknown function (DUF869 topsan)  ali follow..  11  1.............................................................................................................................................................................................................................................................................................................................................................KDALVKQHAKVAEEAVSGWEKAEAEASALKLQLETVTLAKLAAEERAAHLDGALKECMKQVRTVKEEGEQVFAKTKQWEKIKAEFEAKLLEFEQELIRAGAENDALSRSLEERGDLLMKIDEEKAR--------AEAEIEVLKNTIQSGEREINSLKYEIHVVSKELEIRNEEKNMSVRSADVTKQHMEDVKKISKLEAECQRLRGLVRKKLPKNSSFHRPMSPMSPVPDYAFENLQHMQKENEFLTARLLSMEDETKMLKEALAKRNSELQTSRNMYAKTAGKLRGLEVQMLTGSQ. 324
48 -11.900PF13851.1; GAS8_HUMAN/220-420; Growth-arrest specific micro-tubule binding  ali follow..  15  5..............................................................................................................................................................................................................................................................................................................................................................QRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQI----LLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPA--ALTLVSRKLEDVLESKNSTIKDL.............................................................................................. 201
49 -11.800PF14073.1; CEP57_HUMAN/68-245; Centrosome localisation domain of Cep57  ali follow..  10  1..................................................................................................................................................................................................................................................................................................................................................................................................................................AIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQE----LTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLEREQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIF................................................ 178
50 -11.800PF00769.14; MOEH_DROME/332-578; Ezrin/radixin/moesin family  ali follow..  12  1.........................................................................................................................................................................................................................................................................................................................................................................ERAEKKQQEYEDRLKQMQEDMERSQRDLLEAQDMIRRLEEQLKQLQAAKDELELRQKELQAMLQRLEEAKNMEAVEKLKLEEEIMAKQMEVQRIQDEVNAKDEETKRLQDEVED-ARRKQVIAAEAAAALLAASTTPQHHHVAEDENENEEELTNGDAGGDVSRDEHIKDPIEDRRTLAERNERLHDQLKALKQDLAQSRDETKETANDKIHRENVRQGRDKYKTLREIRKGNTKRRVDQFEN........................................... 246
51 -11.800PF13805.1; C5DXD8_ZYGRC/1-270; Eisosome component PIL1  ali follow..  53......................................................................................................................................................................................................................................................................................................................................................................DLARKLSQLVSTEKGVLRSLEVVAYERRAAARQLSLWGVDNDDDVSDVTDKLGVLIFELGELQDQFIDKYDQYRVTLKSIRNIEASVQPTRNRKEKITDEIAHLKYKDPH-----------------------SPKIPVLEQELVRAEAESLVAEAQLSNITRERAAYNYQFDSMRELAEKFALIAGYGKALLELLDDSPVTPGETRSAYDGYDASKQIIMDAEAALESWTLDSAAVK................................................... 269
52 -11.700PF03999.7; PRC1_HUMAN/37-615; Microtubule associated protein (MAP65/ASE1 family)  ali follow..  10  1.........................................................................................................................................................................................................................................................................................................................................................................................LQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEETILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEALDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKRKALQLEVDRLEEKMQNMKKVIEAIRVELVQYWDQCFYSQE. 277
53 -11.700PF10234.4; A7SE98_NEMVE/14-284; Clusterin-associated protein-1  ali follow..  23..................................................................................................................................................................................................................................................................................................................................................................AEVLIWLVKRYDPNVELPMDVETEQDRVLFIKAVAQFMATKAHNTKKLYGADGYAVKELLKVTSVLYNAMKSNVTDDEAEPSDVTSLTFDISSRISDLKASRQLASEITTRGAALYDLLGHE-----VELRDIRTRAIAKPLEVNELENGIKKSISLAQDDIRKTTQMLDNIAS------DEANLEAKIDKKKQELERNQKRLRSLESVRPAFMDEYEKLEEELKKVYETYMEKHRNLSYMEQLLDDVNRAEQDRFE.................................... 271
54 -11.600PF15742; F1SF94.1/171-554; Domain of unknown function (DUF4686 topsan)  ali follow..  11  3...........................................................................................................................................................................................................................................................................................................................................................PSGDRTKSQPQEELQQLRQDLHRLQVLCSSAEKELRYERGKNLDLKQHNSLLQGESLKIKTELKQAQQKLLDSAKMCSSLTAEWKHCQQKIKELELEVLTQAQSGKSLSSLEEALAREKSNVAAAEEKISDLQQKHKVCLAETCILGKKQLEERIKEAMENEAKIKQNYQEEQQKRKLLHQ------NMNELQNQVKTLQDKERQLKMTNVQQQLRIQQQEAQLKELKNERRLCDEHLKSNQELSEKLSGLQQEKEALGRECGRLLKQLDVHVRNYNEKHQHHKAKLRRVRDHNTNESI. 299
55 -11.600PF12084.3; A4WDV4_ENT38/1-107; Protein of unknown function (DUF3561 topsan)  ali follow..  20  22..TWSLPGAVVGFVSWLLALGIFLIYGRNTLFFFLYTWPFFLAL------------------MPVAVVVGIALHSLLNGKLLYTTLITIVAVVAIF-------------GLLFLWLMG................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 107
56 -11.600PF05010.9; Q2NKK4_HUMAN/638-837; Transforming acidic coiled-coil-containing protein (TACC)  ali follow..  1............................................................................................................................................................................................................................................................................................................................................QYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEK................................................................................................................... 200
57 -11.600PF06160.7; EZRA_BACP2/3-562; Septation ring formation regulator, EzrA  ali follow..  10  20.....................................................................................................................................................................................................................................................................................RKNIYKEIDRLEAWKIEILNRSIVEEISKIKHLKMTGETEQFFERWRAEWDDIVTAHLPKVEELLYDAEEYSDKYRFSKAKQVLTHIEDLLSAADSNIEDILKEIADLVTSEEQNRKDIEKVKEQYQTVRKNLLAYSHLYGTLYDKMEQDLDEAWEGIKQYEEETEN--GNYMKARKILLEQDRRLDQLQLYINDVPKLIADCKQTVPGQLTKLKDGYQEMSEKGYKLEHI--QITKELETLNKQLARAEKLLIDELNLEEASSILQMIDDAIETLYDQLEAEVEAGQEIKSRMPELTEAFEKLEQDHTQTKAETALVKEQQKAFEKRLEEIEKLMKQIREKLDRDHVAYSLLMDEINQLETFIEDAKA. 394
58 -11.500PF03082.9; MS2A_DROME/1-264; Male accessory gland secretory protein  ali follow..  21............................................................................................................................................................................................................................................................................................................................................DSEQQLDSAMHLKSDSTKSASLKNVAPKNDETQAKIAKDDVALKDAKKGDYIMDIDISDLPLDDYPINRSKSLKSSSIDLNNIPFNKGLDDFPAKEKNQGSNQSALKALQQRLLTEQNNSLLLRNHSIYLMKEI---------------EARKTDIIKVRQLNLDLELELNTVNRRLLELNGQLQNTRKSTKPCKK-RSSKDSAPPAANQFQEANVRNTYRNKYLTLLKELSQKINNEIAKVATDVPTETNPSQGNLPTL....................................................... 264
59 -11.500PF15233; G3QLD7.1/46-198; Synaptonemal complex central element protein 1  ali follow..  11  1...............................................................................................................................................................................................................................................................................................................................................................................VGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQDTLRILRLHCQEKESEAHRKHTMLQECKERI-----------------------------SALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAREICALDSSKEQLLME.................................................................................................. 153
60 -11.500PF15324; H0UVS3.1/99-1343; Hedgehog signalling target  ali follow..  3......................IFISQYSVGQK---------ALRTILKQ-KAQSI---------------------PIF---------VKVHLL---DAGVEKVAAP--------EARGSPSGIDSATAVAAATAAAIATAAPLIKVQSDLEAKVNSVTELLNKLQETDKHLKRVTEQQTSIQNKQEKLYCHDHE-KQMNVFMEQHLKHLEKLQQQQIDIQTHFISAALKTNTFPPASTLAPRAMEKHSREPGCPFVGGSMLSSHEPFASKQATLRKVEDTYFDEQESPLETPAPRRFAPVPVSRDGEMPKRENPMEEKENMEKSDYKGNTRLLGQILNNNDSSTRKSESSDITSLSRSKLGWNPERRHRFPSSGEPGTAIVTVQKP-NDVLQDLGQKRKETNSV--QAKRISDNVELADLPQSSCKLQTTNTRSVLKDAEKILRAVQNNKKMLEENLEAIIRAKDGAAMYSFINALSTNREITEKIRIRKTVDEWIKAISAEIQDELARKDFEQRRFAQKNQRTQKAQIMSKDIKANTQDKTVNKSILKKPQKQVEDYFRSPPARSMAVSSLQKERKAGPLKSPTMIRDEDYMSQ.................................................. 529
61 -11.500PF03148.9; A7SG13_NEMVE/17-399; Tektin family  ali follow..  13.................................................................................................................................................................................................................................................................................................................................ERQREASHRVRQESRFLRNETDNHTRWTQHDSNTKLEKRIDDINDWKRSLERCLAETDNEIALLTREKERTERALEAKKVPLDITLECLMLRENRQSQLHKEVEVIEGTKALLQQKVDESFEQLCLLQEARHQLHLDITDKFTTLQIDGDCYAMNNMSTNIGYQVNPTRTVKGSVTPETWDSFSNYNKLRAEAEMKASKHLREAIFATLQQTAN-AQRKASEYSFRKRIHETDQAKSELEWQQKNTMKEIATLEDDIKGLKEAIDAKNAPMMVAQTRLEQLCHEVAEIAGSMRALTEKLREAQNSLEALRSNLSRINEDLAFKNN. 366
62 -11.400PF01540.11; O53101_MYCHO/1-353; Adhesin lipoprotein  ali follow..  69......................................................................................................................................................................................................................................................................................................................................................................NKEIAEATKSFKEAGSYGDYPAIISKLSAAVENAKNEKKAIDDKNAQIAKELAERNAKIQSNIEELKKINNEAFELSKTVNKTIAEVEKKFKIEASFKEQLENFADDLLDKSRQIDEFTTVTSTQEGFTLAELESFKEITTTWFNGMKSEWARVLDAWKNELTEINSIIKGEELKKLSHEISEFSNSVKKTISELEKKFKIDDKTNKDEAKQF---KNELENFADQLLNKSHEIDKFVTVTSAREDSLSELESFKSFNTTWFNEMKCEWARVQEAWKDQLKEIST.... 352
63 -11.400PF15294; F6PTH6.1/36-314; Leucine zipper  ali follow..  12  3........................................................................................................................................................................................................................................................................................................................................................................RSRRALRLKTVDSCFQDLKDSLVEETFTVDEVAEMLQGLQAVVHGEVEL--ELINSAHTNFLLLRQLFMQAEKWYLKLHTDISELENRELLEQVAEFEKAEFSSSNKKANTEMIK-PKLAPLFESGPSELLNKEISRLQEENDKLKARLKTIEYQATSALGDKIKAESALKDLQKVQDNQKASNPLCTNTQDINILEKTMADLKCDFEKTVNDHTVSQKYLEDNLASTKHELLRVQEQLSSAEKELEKKFQQTAVYRNMKDILTKKNDQIKDLRKRLQK........ 279
64 -11.400PF09730.4; Q3TBD4_MOUSE/9-723; Microtubule-associated protein Bicaudal-D  ali follow..  12..............................................................................................................................................................ADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLTSVAQELKEINQNVEIQRGRLR----DDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNNLRKELSHYMSINDSKFSDDTVTAEPNNDAEALVNGFEHSGLVKSSLDNKTSTPRKDGLAPPSPSLVSDLLSELHISEIQKLKQQLVQMEREKVGLLATLQDTQKQLEQARGTLSEQHEKVNRLTENLSALRRLQAGKERQTSLDNEKDRDSHEDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAE--EKGRYEAEGQALTEKISLLEKASHQDRELLAHLEKELKKVSDVAGETQGSLNVAQDELVTFSEELANLYHHVCMCNNE.......................................... 467
65 -11.400PF08172.7; CASP_SCHPO/399-628; CASP C terminal  ali follow..  10  1...........................................................................................................................................................................................................................................................................................................................................................................................................ITQESKKASFLEQKASEQEEVIRKLEKDLADVDVEGSVYLSNTTYRREGTSGQLSPTSSIMGGNPSLFNGSVLSRNSVNETGSAIVDVIKQQRDRFRRANVTLVNQVSAANDKIALLESKLEEVEKSNTLLYEQDHYQKHVEPSSSHLQTAAAYENSISPFASFRKKEAERAYSRMGSFER....................................................................... 185
66 -11.400PF05769.6; Q4SCC6_TETNG/1-189; Protein of unknown function (DUF837 topsan)  ali follow..  13  1.....................................................................................................................................................................................................................................................................................................................................................................................................................MSCTWENVLGDARTLLERLKEHDTAAEGLIEQSGALSQRVHSMREVGNGLPDKHIEDASEIQELGK----------HKPHVLLTQENTQIKELQQENKELWLSLEEHQYALELIMGRYRKQMLTLMMAKKELDTKPVLSLHEDHAKEVQSQLERICEMGQVMRRAVRVDDQNYCSVRERLAQLEIENKALQDLLA............................................... 185
67 -11.200PF11168.3; Q1ZA28_PHOPR/25-164; Protein of unknown function (DUF2955 topsan)  ali follow..  2............IFRYVIGLVVACALAFGIGWGLSFVAPVFKFLVDHQKPTSHTISQLLLAMTVTVLIGLSVSAGIYPLPLLLLLSLLMFTAYYLFMDPQWNFFATILMIAVMLLPFMGIISPGL.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 118
68 -11.200PF05384.6; A4J6C1_DESRM/9-167; Sensor protein DegS  ali follow..  12  1....................................................................................................................................................................................................................................................................................................................................................................................................DNIIKETISVIEKSKEQIYYIAESAHLEWQRVENEIKQTKYQLGKIIDEVNKLEIEERRARVRLMEVSRDFDRYNEAAIKQAYEQAQVTQLRLVMLREEEKTLRFKRDHLEISLKRMKDTADRAEKLVSQVGVALQYLSK------DLSGVSEKLTNLHDMQQ................................................................................................ 157
69 -11.100PF10498.4; IFT57_XENTR/25-384; Intra-flagellar transport protein 57  ali follow..  10  63...........................................................................................................................................................................................................................................................................................................................................................QEYDDPNATISNILSELRSFGYSVDFPPSRLKAGYGEQCFAEEVLKHIHFSWKRPTYPTEEQDEENVIEDDAELTLNKIEDEIAEEDSDNDQEHFIDLNALSAQTQKLNTKESSKPEEILESNTDAAEWILEVERVLPQLKVTIRTDNKDWRVHVDQMHQHRDGIDTSLKETKGYLDKLHN--EVAKALEKVSSREKYINNQLEQLVQEYRSVQAQLSEAKERYQQASGGVTERTRILAEITEELEKVKQEMEEKGSSMTD-GAPLVKIKQALTKLKHEIVQMDIRTGVVEHTL...... 359
70 -10.900PF07246.6; Q88304_SFSV/4-294; Phlebovirus nonstructural protein NS-M  ali follow..  48..........................................................................................................................................................................................................................................................................................................................................................................GFEMAKMPGFDLHCRFNEEGDFKYMTHENAMKQIKIVTTAPDTMKFSCGETKSLGLSITNDGTNNMMGPAIIYCDTNDFIRNITTGEQSPRVDYEKLKKNAEEKDATIQRKTKEMEEVRAVLDSRNQIAHHEIQQKENEIQKLRNDLRDAIKKGQEHESMKLRVEESDARVKGLKEELKQLTYKIFDHQATKDELQHAKSEMQSLRKKIKDFESIPQAKKSSNSSVTLMTTAVLSLLGS.............................................. 287
71 -10.900PF10473.4; Q9GKN4_CANFA/3-142; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1  ali follow..  13  2...................................................................................................................................................................................................................................................................................................................................................................................EKKQLHVLEKLRESERKADALQDKIENLERELQMSEENQELVILDAENSKAEVETLKTQMELTTKSLKDLESDLVTVRFEKENLIKQLQDKQGQV---------------SELDTLLSSFKGQLEEKEREKIEMKEESRAALEMLRTQLKELNE.......................................................................................................................... 140
72 -10.800PF13514.1; B5J9R5_9RHOB/33-1144; AAA domain  ali follow..  457............................................................................................................................................................EHEKISQTIHNTIDKRDNHQEDLATRIAQGKVLTAGGAVVTDAETEVLLTAREDLWAEHQAALESQTASAFYEAMQKHDKAMDARVTHASELGQLRQIEQAEVEAQIRLEQADKRLEVLDKELTALDAAVGAAARQITSAEWLDWVARNSTATEDAQALFAAREEHQPILDRAEDLRAELSRLLTFEATDVASALTVARQVAEGERKQSENEARAQETLQQAKRNLRKREERHQAALSVEAEARNAWYTLILEMLGDRIAPENLQASLEPL-RELREHAKTRASAAQRVASMKVDQERFAEEVAALAKAYNLETLETAAETFSALKTLSDRARSAHEAVEKLTGDIKEAEARKSKNSEKLREIKQAIEAIASGFPYSTSLTEIDQQVIEERAALVKLQRTVVSELGVNDIKAAREEMAALSLTDLEAAFENSKSDLERAEEELTQAIEIRVAAEQGVAQVTGDADTLVEQKATLELQLEDSALEHLELS.. 961
73 -10.800PF15290; H3CN48.1/194-511; Golgi-localised syntaxin-1-binding clamp  ali follow..  11  58...............................................................................................................................................................................................................................................................................................................................................RPPNPEQYLTPLQQKEVAIRHLRTKLLESENRVHDREAEIQDLKTQLSRMREDWIEEECHRVEAQLSLKEARKEIKQLRQVVETMKSSLMEKDKGIQKYFIDINIQNRKLESLLRSMELAQSGTNLQDENTLDFLCERPN------GGGNKLVGEEGHGLEMGEQGVEAMADSGLLINDEIASRVDILEQVFMSTAVDSQDCKRRADPGVSTLSEDPLMIGEPPKPRSNPISSATSVKQSTEDKGMQTDAMPCSPDLSALVLQLLQ.............................................. 318
74 -10.700PF03383.10; O62449_CAEEL/34-184; Caenorhabditis serpentine receptor-like protein, class xa  ali follow..  11  4..........TVYIYNMIISSSVDIIVMFITFILPVTMT------TINCTFFY----EHPLYLTFLMSIQRIYAVFQPFNQHF--TNGKLWGYCA-----IVAIFSWILLLIPFFSHCPVNINQRVFSFAVACQEQNKYLIILPFTTMLLNV............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 151
75 -10.700PF05335.8; Q8T4I3_DROME/75-260; Protein of unknown function (DUF745 topsan)  ali follow..  13  4...............................................................................................................................................................................................................................................................................................................................................................................................................................................SQKNAKSKASSIAIKAAQDAKAANDAQMAAGEAASLQVKQDLAEKAVQAARAAEAALAGKQQIMEQLELEEKEAVAVVDEVKNSLHSTQVNAESAMLASEAKIQLDQLKVLLAEATAQMTNIETFANGAQLEMDEKGQLLEAANRRVESISRQVVAARQDYDKTKKAAYKAACAAVEAKQK................................... 185

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Jaroszewski L, Rychlewski L, Li Z, Li W, Godzik A. FFAS03: a server for profile--profile sequence alignments. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W284-8.