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Query: PF09726.7; H2MT57_ORYLA/2-679; Transmembrane protein, from PfamA30U

Results of FFAS03 search in PfamA30U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst KRRNADCSKLRRPLKRNRITEGIYGSTFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVFFVCVAFTSDIICLLFIPVQWLFFAASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKNFHVDLCRPFAAHCIGYPVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQQMLQRQEREAEEAAKGASEVETLPVTQNGAPPNKKTSVPLPELEYREKGKDGRGGGEAKKQHNSNNILQPSLDSKIHEMEYMENHMNKRLTTELDSTESLLLKEDNNSSCSSSSSSSSKNYKNASSNAAALNSSPRGHSTTNGSVAFSASSSTTNTAKNDKKHKLPVGKGTAGGSHKDPADNWIPNNQLSKPEALVRLEQDIKKLKADLQASRQVEQDLRSQISSLGSAERSIRTELGQLRQENELLQNKLHNAVQAKQKDKQTVGQLEKKLKGEQEARATAEKQLAEEKKRKKLEEATAARAVALAAASRGECTDTLRRRITELETECKKLTMDIKLKEDQIRELEIKVQELHKYKENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQMIQKDQEIKDLKQKIAEVMAVMPSISYTTDTSSMTPVAPHYSSKFMDTSPSGLDPNASVYQPLLast
1 -101.000PF09726.7; H2MT57_ORYLA/2-679; Transmembrane protein  ali  100  1KRRNADCSKLRRPLKRNRITEGIYGSTFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVFFVCVAFTSDIICLLFIPVQWLFFAASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKNFHVDLCRPFAAHCIGYPVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQQMLQRQEREAEEAAKGASEVETLPVTQNGAPPNKKTSVPLPELEYREKGKDGRGGGEAKKQHNSNNILQPSLDSKIHEMEYMENHMNKRLTTELDSTESLLLKEDNNSSCSSSSSSSSKNYKNASSNAAALNSSPRGHSTTNGSVAFSASSSTTNTAKNDKKHKLPVGKGTAGGSHKDPADNWIPNNQLSKPEALVRLEQDIKKLKADLQASRQVEQDLRSQISSLGSAERSIRTELGQLRQENELLQNKLHNAVQAKQKDKQTVGQLEKKLKGEQEARATAEKQLAEEKKRKKLEEATAARAVALAAASRGECTDTLRRRITELETECKKLTMDIKLKEDQIRELEIKVQELHKYKENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQMIQKDQEIKDLKQKIAEVMAVMPSISYTTDTSSMTPVAPHYSSKFMDTSPSGLDPNASVYQPL 678
2 -16.800PF07888.9; CACO1_DANRE/5-593; Calcium binding and coiled-coil domain (CALCOCO1) like  ali follow..  10  1.........................................................WVEFRNVGSCY-----------------SRVDCHYTISNDWILFKVG--------WSSVK---------YHTFVWAVAPSSYKEGTSVNCCV---------------------------QASYLPGPSAQQYQFVYVDGKGEICSCSAAFTFSAPKPLEELVTLEEEGQGEEVGEDMLLVIPRAQLLQSRLQECLKERAELLQALEAADQNVEREKGRRERDRGSWEHTRKELERKIDDLKEEVREYREKVEDMKKKQKEVEDLGEALTEEKRALLAQKEANEQRIRELEEDIKILTQRGLERETDLERMRERAKKSAAQKREDEDEHKNLKLKMEQTEKELHSLSAEFQSLRSSLAQRDTHALQLRDTITTLTHKLNSAHRKEAANELALNELRS----VQERLNVSEHCVETLRGELRDMVAQRDSAHAELHQARLQAAQLTLQLADASLALREGRANWAETLQQNAEIDKVRLERQNDEIQQKEEMLQKARMEREKAVVEGREKDCNRELKASLRVAQKEKEQLQTEIQEVMEYSRQLERRLEVLSDCKWSETALLQSSRAESPLLSDSEDENPEALQDTHSSGPLNHYSLCEQPQSDLLLPATPPPSPRHPSTVV.. 573
3 -16.100PF15921.3; G5BJQ7_HETGA/1-1111; Coiled-coil domain-containing protein 158  ali follow..  10  339...............................................................................................................................................................................RMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDMGNSITIDHLRRELDDRNMEVQRLEALLKTMKSECQGQMEQQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLENSERTVSDLTASLQEKERAIEATNSEITKLRSRVDLKLQELQHLKTEEEHLQHAQTECEAQMAGKDKVIEILRQQIENMMQLVGQHGRTAGAILVEKAQLEKEINDRRLELQEFKVLKDKKDAKIRELEAKVSDLELEKVKLVNAGSERLRAVRDIKQERDQLLNEVKNSRSELNNLSEDYEVLKRNFREEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGADGHAVKVVGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTL.... 844
4 -16.000PF00261.18; I3J233_ORENI/12-247; Tropomyosin  ali follow..  13  1...................................................................................................................................................................................................................................................................................................................................................................................................................RKIQCLQQQADDAEDRAQVLQRELDSERELREKAEGEVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKY-EEVARKLVILEGELERAEERAELSECKASDLEEELKNVTNNKSLEAQSEKYSEKEDKYEEEIKVLTDKLKEAETRAEFAERTVAKLEKSIDDLEEKLSHAKEENLGMHQVLDQTLQELNS....................................... 236
5 -15.700PF01576.17; G3Q6K2_GASAC/841-1921; Myosin tail  ali follow..  405...................................................................................................................................................................................QRRKKAESQVQELQVKYSESERQRQEVAEKITKMQSELEHVNSLLSEADNKNIKFSKDISATESQLQDAQELLQEETRQKLALSTRLRLVEDEQNNLREMLEEEEEGKKNVEKQITTLQAQLADMKKKLENESLSVEGAEEGRKRSQRELEGVMQQLEEKTAAYDKLDKTKTRLQQELDDLLVDQDHLRQIVSNLEKKQKKFDQMLAEEKTISTQYAEERDKAEAEAREKETRALTLARELETLSDVKNELDRANKMLKAEMDDLVSSKDDVGKSVHELERSKRAMDQQLEEMRVQVEELEDELQATEDAKLRLEVNMQAMKAQFDRDLLARDEQGEERRKQLVKQVREMEVDLEDERKQRSHALSAKKKLELDLGELEVQEAANKGRDEALKQLKKLQALMKDQMRELDELRLSRDEAVNGAKETERKLRAMEADALHFQEDLATAEKVKKQVQAERDELQEEISSTNTKNSVLAEDKRRLEARITQLEEELEEEQ.. 902
6 -15.600PF15070.4; W5MC41_LEPOC/402-1036; Putative golgin subfamily A member 2-like protein 5  ali follow..  1................................................................................................................................................................................QLMESVQQLKTERDQYAAQLQEEGKVWKDRTEQLLSQVNSLSEEKERSMTQIQELENLV--IELRNASALLSQEREDQAAPEPTGPSENETALQEALGKLQQEKDDLSTQYQAQVRDNEQLSRLCQEQEERLLELERTVQRFSEDAVDRQQILESMQSDKATISRALAQNRELKEQLQNGFVKLTNENMELMSALQSEQHVKKELAKKMGQMQEELHQSREELEGKTQEARSLLEQRDQYLAHLQQYTAGYQQLVAEREELHKQYLHQVQLMDRLQHEEVQGKVQLELSQKELERAKEKLTQLAKDNESLKTEVKELTGLGTQPRDQGDGVESKSPAESQSALSQVEREWDEVSRLYEEEQRLHQAALQQVAALRSEHQHHSTAAAGPAGDGVPVEVHEALRAAMEKLQSRFTALMQEKADLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAIMKQRHMEKEHYISMLAKDKEEMKAKLAELQDLVLRLVGERNEWYS. 524
7 -15.400PF12128.6; Q8EAA0_SHEON/8-1195; Protein of unknown function (DUF3584 topsan)  ali follow..  316...............................................................................................................................................................................GDVAKCEYELDAIEDQHGAFLDANIEQAKADLDMLPNWRADMENLSERHKLQTEKHQDIEANARRSKIGEQLNRELEGLHSEQDKQREARDKQREVARGDLDALEAQWRSQMDAGKASFSEQEYQFKLNAAELKLRVDGVTYTEEEKLNLAIFDERIHRADEEQESCNAKVERLTSDERKLRAKRDQANEALRIASLRVNERQTALDELHHMLFPQSHTLLEFLRKEAQGWEQLGKVIAPELLHRTDLHPSVTGESDTVFGVNLDLKAIDASEQELRIRLSKAEEALQSAQELQAEAESQLVAINGELDKLSRELTFARTAYKNSRDDLRRLFDEKRSEQDKINKALAERKAFAQQRLTQLDGELKQLKHQHQLWLEEQKE-QALEARMEKQAYWQEVIGALDNQLGQIKATIDARKAEQKACETWYKNELKSRGVDEDNILKLKQQIRELETKISRAEQRRSEVLRFDDWYQHTKPKLQTQLSDVKRAASEIDQQLKAKTQ. 832
8 -15.200PF04849.11; H3AF28_LATCH/123-428; HAP1 N-terminal conserved region  ali follow..  1..........................................................................................................................................................................................................................................................................................................................................................................KEGVPHYTLRADTIFGYDHDDWLHTPLLPPEANLELTPEQIEETLKYFLLCSERVGRVTKTYHDIEAVSHLLEEKERDLELAARIGQSLLKQNQSLTEKDEYLEEQLQLAKEEIAQLRHEIAMRDDLLHVYTNTAEESESSSTVSTPLRRNESSASLQ-HYIHLDFLQEKLRGLEEENQKLRSEATDMVTETVDFEE--QEQQLMIDCVQELAEANREVGMLSEELARKTEDILRQQEEISQLLAQIVDLQQKCKSITTESEELSQHLALSRERQEQLRLELKDLQEKHAEYKELLQETREENKNLRNK....... 306
9 -15.100PF15905.3; HMMR_MOUSE/15-339; Hyaluronan mediated motility receptor N-terminal  ali follow..  12  13.........................................................................................................................................................................................................................................................................................................................................................................KTSEATKGPVSFQKSQRFKNQRESQQNLNIDKDTTLLASAKKAKKSVSKKDSQKNDKDVKRLEKEIRALLQERGTQDKRIQDMESELEKTEAKLNAAVREKTSLSASNASLEKRLTELTRANELLKAKFSEDGHQKN--MRALSLELMKLRNKRETKMRSMMVKQEGMELKLQATQKDLTESKGKIVQLEGKLVSIE---KEKIDEKCETEKLLEYIQEISCASDQVEKCKVDIAQLEEDLKEKDREILSLKQSLEENITFSKQIEDLTVKCQLLETERDNLVSKDRERAETLSAEMQILTERLALERQEYEKLQQ. 323
10 -14.700PF09728.7; W4Z3B2_STRPU/161-468; Myosin-like coiled-coil protein  ali follow..  1...............................................................................................................................................................................................................................................................................................................................................................HMSRAIMQALNGLETPEDKIAALCKKYAELLGEHKSLQRDSKTQTKQLSQIQRERDHLQSEHGRALLAKSKLESLCRELQRHNKTIKEESLQRAREEDEFQQTINEITTQMQDNHTRNIKLKEENIELASKLKNLVEQYERREEHIEKLFKHKDLESQLYDAKLQQSNLALAEEKERNKREKELLIAESVDSKRRLEMFTKQEAQLKAQLAVTEKFEEFQSTLTKSNEVFQTFKQEMDKMTKKIKKLEKETNLWRGRWETSNKSLMTMVEEKGRHEKDMSDKLIKINRLEKLCRALQAE............................ 308
11 -14.600PF09311.9; F6RFI5_XENTR/524-830; Rabaptin-like protein  ali follow..  5..........................................................................................................................................................................................................................................................................................................................................................................................SNYEKQLQGIQTQEAEIRDQVKKLQSMLRQVNDQLEKTLKDKKDLEDYMKQNTEETSTQISTLTLLADLQQAFTQAKRNIQDQMAVLMHSREQVSEELLRLQRDNESLQGKHSLHVSLQQAENFSLPETSEELQNLVLKYREDIISVRTAADHLEEKLKAEILFLKEQIQAEQCQKENIEETQIEIENCKEEIASTSSLKLELDRVKAEREQLEASLQEKTRALQNLQTLKDSLEDQLKKETGGKASLEQLVFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQT....... 306
12 -14.600PF17078.3; SHE3_CANTT/23-265; SWI5-dependent HO expression protein 3  ali follow..  2.............................................................................................................................................................................................................................................................................................................................................................................................TKVIDSLHSKIDELTDELTTLKQSHQELTKKHSIVAKKNDSFVDQLANAKHENDMLSALLKRKERRILDLEDQYNDLNSQIENLSLSNKNMKIRCENLQNNSNASIAEFERLKISYDALIASQMEYKNHYQQELNTLQTSFDKYRTENTKRYEDLQSSISSNDKDIDTLLDSLTNKRKTMD-----NIYVNKNNKILQLLTSLASLIKLHAEDTKGQVEQNVDVIKILMEKYPDLQEKILEKEKVE................................................... 242
13 -14.500PF06818.13; H3A1M8_LATCH/446-647; Fez1  ali follow..  18  2....................................................................................................................................................................................................................................................................................................................................................................................................KWEVCQKSGEISLLKQQLKDSQVELAQKGNEILSLKAQLRGVRAELQACEDQLQELQEAAHTKTLELEVCENELQRKKNEADLLREKVGKLEREVAGLREMVARSRQSQEQEDAFLLYESDEAKAQRQNA-DTLLGLRQQVERLKAELLYERRRSEDQLEGFEEERRTWHEEKEKIRYQKQLQHNYIQMYRQNRELEREMR......................................................................................... 202
14 -14.500PF14915.4; G1KGA5_ANOCA/157-457; CCDC144C protein coiled-coil region  ali follow..  11  2......................................................................................................................................................................................................................................................................................................................................................................................QILQDELSVLRLELDRIRIQHQEQESKYLEENEALKEKIEELKLNEDALTQTVFQCNGQINISKTEAAMLTTKLEHIKEHKERLEMEINSFHSRLNSTAQELERCQLGKNDAERVLQRERDEWIRLKDKLNHDICTL----REASNTMSQQLSKSESKANGLENELHQVTYTLREKSLLLESCQRDNQAQGQVKELENARQAEKDQMNKYIVKHDSMQERLAQLQSENLLLRQQLEDFQNKSIIKEKVVTDVQDRFNDIFSKLRDTEKQVQLMEERNKELVTKCDNQREQVLKYEAEKADRE.. 301
15 -14.400PF10174.7; H2T771_TAKRU/113-856; RIM-binding protein of the cytomatrix active zone  ali follow..  10  1..................................................................................................................................................................................QAQLRNLQRENDNLRRELDRGRSCSTNNVNFWSPEVKRDKGVRREEGVRSLKDQYRSNHEDLQQLPLTVQELQEELRAHREMNSRLQHQRQQGNSGSYPPPLDPSEENFLRLQSDHERQAKELLLLRKTMEEMETRIDSQKQTLDARDESIQRLLELLQGQGQGTWSRGHRAGIITMAAQEAEAHELQRRTQPQAEPAKTRALQAVIDMKDTKISSLERNIRDLEDEVQMLKTSGLLQPDDRQDELKQVEVYKSHSKFMKMKIEQLKQELNKKESEMQALQTKLETLTNQNSDCKQHIDVLKESFSAKEQRANTLQTEVDALRVRLEEKEQFLTKKTKQL-QDLTDEKSTLTGEIRDLKDMLDVKERKVNVLQKKIENLLEQKDKDKQLAGLRERVQGFQTDSSNTDTALATLEEALSEKERVIENLREQKETRLEELDQMRKENQELKDKLTALQPPKELKEFSLVDLMCSSQAVFTLLTSTPIKDLDVWSHHKSAA.. 510
16 -14.400PF15934.3; B3MK61_DROAN/489-722; Yuri gagarin  ali follow..  1.................................................................................................................................................................................................................................................................................................................................................................................................................ILKEIADLICKLRSTDFSYNEIY----NETSTENPFCVAIMEMFDEKSEQTEKEYESLAANERLVCQISALKETLNDRNELINHLQSMIGNYSDMSE------NNRLKEENHDLKMKNSENIRKAREIAEQLNGQVTQRVELVNKYESLSSSFEEQCQEKGANRRVQSLQTRLCQVEKLQEELRTERKMLREEVIALKEKDACSVGRERALQDQLRCSQMDLDKSRCLIRNMQSQLQQQDKL................................... 233
17 -14.300PF05483.10; SYCP1_RAT/28-813; Synaptonemal complex protein 1 (SCP-1)  ali follow..  10  32...............................................................................................................................................................................RENIDTDPAFQKLSILPMLEQVANSGSCHYQEGVNDSDFENSEPMSRLYSKLYKEAEKIKKWKVSIESELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHWCNLLKETCARSAEKTSKYEYEREETRQVYVDLNNNEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYQKEVNNKENQVSLLLIQSTEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELNEKKDHLTSELEDIKMSMQRSMSTQKTLEEDLQIATKTIYQLTEEKEAQMEELNKAKTTHSLVVTELKATTCTLEELLRTEQQRLENNEDQLKLITMELQKKSSELEEMTKFKNNKEVELEELKTILAEDQKLLDEKKQVEKLAEELQGKEQELTFLLQTREKEIHDLEVQVTVTKTSEEHYLKQVEEMKTELEKEKLKNIELTANSDMLLLENKKLVQEASDMVLELKKHQEDIINCKKQEERMLK. 534
18 -14.300PF06008.12; LAMA1_HUMAN/1575-1831; Laminin Domain I  ali follow..  5..................................................................................................................................................................................................................................................................................................................................................................................................NLTGIIPVPYGILSNLENTTKYLQESLLKENMQKDLGKIKLEGVAEETDNLQKKLTRMLASTQKVNRATERIFKESQDLAIAIERLQMSITEIMEKTTLNQTLDEDFLLPNSTLQNMQQNGTSLLEIMQIR---DFTQLHQNATLELKAAEDLLSQIQENYQKPLEELEVLKE--AASHVLSKHNNELKAAEALVREAEAKMQESNHLLLMVNANLREFSDKKLHVQEEQNLTSELIVQGRGLIDAAAAQTDAVQDA................................... 256
19 -14.200PF04094.12; Q7XPH2_ORYSJ/208-1047; Protein of unknown function (DUF390 topsan)  ali follow..  11  272...............................................................................................................................................................................ARARRAEEAAREEAARARQAEAMASSEAVHDKTAGASLGPTPSGDAQATTSGAARDKAAGASPGPAPSGDAQDQTGPGDIPELSASSGGPSRVAFSPRRLFSSSSAAPLSAEPLLQALAAANTAVLDGFSAQVEALRAERAELEAAWTRVEEGRRSVDAMVEVGRKAHRRHISELEARKAALAEIAREVEE------EREAALIATTAMIEAQDSLRLQHGSWEAELKKKLDAAQGVLDAAAAREQRATEAKAACRQREEALEARAMALEDHAGAVEISLADREAAAAIREVTLAAHEAACAEEESALRLREDALAERERALEESEAATQRLTDSLSLRKAAQEEQARRNLECIRAERAALEQRAANLEAREKELDAR----ERSGGAATGESDLVARLAAAEHTVADMQRALDSSTGEAEALRLLGEIGPGMLWDAVSRLDRAGREAGLWKGHTISHSTNLEGLAPHLRRMAWAVQRLPEELEKTIKSSS............ 752
20 -14.100PF05557.11; G3PW04_GASAC/52-714; Mitotic checkpoint protein  ali follow..  44...............................................................................................................................................................................EHEVDRNQDLLGRIKKLEERETEEAKNLSEQVEVNRSLRKNLDGLNRKVEERDTRLNTANQTISSLKDEIRELKQKIQNQDSAVSSHTLENQELQEHLDLQRRKYQEVSQLCQSLQAAQSSCSEHIITIKELERRLALQEQDFAIVKNIKSEVARVPDLERDLKRLREDNAFRESRENCSLLKEEVEGLRKKLERTERTKEELVNMELEKERVAEKLRAWETIGQSTGRKPEDLSREVIHIQQIEISLKEQNYTLNSRVRSAERSQAELRAELSKQRGRTQEEQKKREAQDALVRRLQKRVLLLTKERDGMRAILESYDGELAPAEYS--PQLSKRLREAEEVLQRTQKHNVEMEGQLTKAQEEAGTLKLQLHAVELEMESLRKQSILRQKIEDLEAERQSLEQQNNVLEMRLERHNLQGDYDPVKTRVLHLKMNPTATAKQQRQQDGEALREEVTRLREVVRSDESGLSLPVLGSFLCNHNLVNLRKQMESSELRNQRLKE. 567
21 -14.000PF04582.10; Q9DPB5_9REOV/1-326; Reovirus sigma C capsid protein  ali follow..  3...................................................................................................................................................................................................................................................................................................................................................................................GLNPLQRREVVSLILSLTSSTTTNPGDLTAVYERLTNLEASTKSLRQSLSSIVSDLSDVSVDLQDTTRALDDAIATLKGLNTTVAALQNSVASLSSTVNGLTDISSAHSEALSFLRTTIDGNTVAISNLKGDVSTNGLNIADLQNRM-KSLESSTSHGLSFSPPLSVADGVVSLDMDPYFCSQRVSLTSYSAEAKLMQFQWMAKGTSGSSDVIDMTVNAHCHGRRTDYMMSSTGGLTVTSNAVSLTFSLDYITNMPSDLSRLIPSVGFQAAS................................... 273
22 -14.000PF10481.7; G7NUK3_MACFA/1-307; Cenp-F N-terminal domain  ali follow..  12  2................................................................................................................................................................................................................................................................................................................................................................SWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCSTPQKIFTTPLTPSQYYSGSKYEDLKEKEVEERKRLEAEVKALQAKKASQTLPQTTMNHRDIARHQASSSQEKTPSHLSSNSQKTPIRRDFCASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLEQLKVQNQELRSKINELELRLQGQEKE............................ 307
23 -14.000PF13779.4; D7A9C0_STAND/55-942; Domain of unknown function (DUF4175 topsan)  ali follow..  428...............................................................................................................................................................................NIGRSRPRTFVLPERSFSNPLARALIDERRVLAFDANQRERVEAGLDALAIAPEKFTPDPSHYMGLRSAYWRLANAKSDEDLRGVVAYLWEIAVRIEDGDLSDVEKKLRDAQQALQNALENNASDDEIKRLTQELREAMQEFMQALAEEAQRNAQADSDQPMGPNTRMVRPQDLQKMLDRIEDMARNGAR--DAARQMLSELQNMLNGLQAGRQQQRRQGQNQMSQAMDQLGDMIRRQQQLRDRTFKQGRE--QGQQGEQGQQGQQDQRFGDLKQSQEQLREQLRQLREKMQQAMRGRQQGQGEQGQQGQGEQQGQNGQGQQGQQGEGQQGQGMPGEGGLGEAEQAMREAEQALGQG-GAVDAQSEALQALRKGAQQMAEAMQQQPGQGQGQEPGGPSGETAERNDPLGRPMRSRDYGDDVTVKVPDEIDMQRARRVLEELRRRFGEPERPRLELDYLERLLR........................................ 888
24 -13.700PF15818.3; G3T452_LOXAF/26-1066; Coiled-coil domain-containing protein 73 family  ali follow..  1.........................................................................................................................................................................................................................................................................................QLLDFKTSLLEALEELRMRREAETQYEEHIGKIIVETQELKWQKETLQNQKETLAKQHE----------EAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKLSEMEQKVQLHFLAKEDHHKQLNEIEKYYAIITGQFGLVKENHEKLERNVQEAIQLNKRLSALNKKQEFELCSLKKELKKVTSDLIKSKVTCQYKMGEENTNLTIKERKFQELQERLNELNKKINEEISRIQEEKQNVIISFQHMQQLLQQQTQAAEMKAELKVLKENNQTLERDNELQREKVRENEEKFLNLQNEHEEAKKHVEELNGEINEIKNELSSLKETHIKLQEHYNKIYDQKKFEEDKKFQNVPEVSNEHSRMSAEKSEDTTILT. 394
25 -13.700PF05667.9; CCD22_AEDAE/1-553; Protein of unknown function (DUF812 topsan)  ali follow..  186......................................................................................................................................................................................................................................................................................................GDVAAEVKEFWSRRNLDCLDEGSLVPSLIAANDGAIKTNAKGAIDEVDRQVKLPAINEKLLQYYSKGGTKHRLAEPSGAAASSGTTEKVVLNNITVETKPGKTPLESLQEEIDALQQEIVQHSEEGVQLESSRKETDESIEEYRKTIVRLKEEKKIKERTHILLEDP----EVNVKKLEAIIAAGGERMKKLQDQWDAHRIPLVDTLEAYRLKNSDKLSKSQQVLDQIE----STRQKCEEVVIDLQTKGAMYARLQKEFEKLNKTVSRTAYTSRILENIRKQKNGIDQILQDTRSLQKEINNITGQLDRQFTVTDDLIFRNAKKDEHSKRAYKLLVTLHSDCEELIKLVQETGAIKREVRDLEDQIENEKGR........... 553
26 -13.600PF15964.3; SDCG8_HUMAN/6-706; Centrosomal colon cancer autoantigen protein family  ali follow..  10  214...............................................................................................................................................................................AGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKEASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDEQYLLLTSQNTFLTKLKEECCTLAK--KLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL.................... 700
27 -13.600PF15254.4; G1T8F1_RABIT/39-892; Coiled-coil domain-containing protein 14  ali follow..  241...................................................................................................................................................................................QQGVPKEADLLKCFQTYMSLFQSHGKETHPDNQTYQSPTRSQQAFLASSEDKDAREQIGESTSEGKDLNIHKQDAKMVKDVQKAKNVNQTAEKVTTIKYFLGELKALVAEQEDSEIQRLITEVEACVSELPAVSGNTNIQVEIALAMQPLRSENAHLRSRQLRILNQRLREQEKTKKTTGSVECNLELFSLQSLNMSLQSQLQESLKNQELLQSKNEELLKVIENQKDENKKYTSIFKEKDQTILENKQQFDIEITKIKIELEEALVDVKSSKFKLDTAEKENQILGITLRQRDAEVARLRELTRTLQNSMAKLLSDLSVDSARCKSGNNLTKSLLNIYDRQLQHDPASIMSYLNKLETNHSVAHLEPLSTIKNEETTEPDRPYENVLGIISALSKQDSDAENETLTVIEDECNLDSTVYIPFVRSTSKMNSPLSKRLSPQPQMSVAITQLVGNSGLVSETEKKLCAHAVTCSSRQEVEDAHEKLSRTADTEDKQLLK. 761
28 -13.500PF05622.10; H2QW41_PANTR/12-710; HOOK protein  ali follow..  11  119...............................................................................................................................................................................EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEI--DVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKS. 645
29 -13.500PF10168.7; I3KZS6_ORENI/8-718; Nuclear pore component  ali follow..  12  468..........................................................................................................................................................................................................................................................................................................................................................................LSSIRPPSPPLLCSHPGLGSASSPLRGLAEDSFEQHIRNILARSSTNPLVLKAGDKDTSPPPPELELLSRATQVFREEILKQDMAREEMQRRVKLLTGQKNKQLEELSLCREERKSLREAAERLADKYEDAKYRQETIMNRVKKVLCSL----QSQLPILSNSEKEMKKELQTINDQLKHLDNCIRQVNMKMEYQKT--QVDKDMPGTRARVSLNAPQKKVVQDVLKEQGQQIGDMMKQIKDIKNHFS.................................................................... 711
30 -13.500PF14662.4; H9GPA1_ANOCA/135-325; Coiled-coil region of CCDC155 or KASH  ali follow..  12  1.................................................................................................................................................................................................................................................................................................................................................................................................................................EEAADLMNSIKDLQQGNKQLAVQNTKLQRTIETAEELNSRLSEEISELKGKLRSTQQALEQARAVANELED-------------------LKVFSKTLEEENNRLHAQTRQLEKEQQLLFVRVDNLQEENKKLLTEKENSK------CKIKELFTKKASLKSKICEYEKLTSCKDAALNEKTKRIEELTMILDEYRTVVEELRLEVRRLQDHLCQ.............................................. 190
31 -13.400PF05911.9; U5GNM3_POPTR/17-877; Filament-like plant protein, long coiled-coil  ali follow..  10  1.........................................................................................................................................................................................................................................................................................................................................................KENLVKQHAKVAEEAVSGWEKAEAEALALKNHLETVTLSKLTAEDRASHLDGALKECMRQIRNLKEEHEQVLNKKKQLDKIKMDFEAKIGNLDQELLRSAAENAALSRSLQERSNMLIKISEERSQAEADIELLKSNIESCEREINSLKYELHVTSKELEIRNEEKNMIMRSA-EAANKQHTEGVKKIAKLEAECQRLRGLVRKKLPGPAALA---QMKLEVESLGRDYGDSRLRRSPVKPPSPHLSSVPEFSLDNVQKFNKENEFLTERLFAVEEETKMLKEALAKRNSELQASRNLCAKTASKLQSLEAQFQINNHQKSSPKSITQV.... 330
32 -13.200PF15619.4; C3YX78_BRAFL/18-210; Ciliary protein causing Leber congenital amaurosis disease  ali follow..  11  3..................................................................................................................................................................................................................................................................................................................................................................................................................RRILSARRVKIKDLTSQIFELQRELDDLRRENKLLKTLQHKQEKALTRFEDQESDLPQLLARHSAEVRNLKERLRHKQDSNHRSEQKIKDLRDDLEKKEHQVSKLQKIVRDKNLAERDELNRKLMRTEQMLLDKEKKVTELNKH------------------------------LELVQGSSTRQLNAERARHKETQDKLSSLQEEYERLQNKLKEKEKEL....................................................... 193
33 -13.100PF07111.10; CCHCR_MOUSE/27-758; Alpha helical coiled-coil rod protein (HCR)  ali follow..  2.................................................................................................................................................................................................................APTWASDVPLVQSPASQDVLERRLDAQRSTVTTWGQDFCGDGQGLGRRGRSLELGFSSALSQQAELISRQLQELRRLEEEVRSLRETSLQQKMRLETQAVELDALAVAEKAGQAEAEGLRTALAGAEMVRKNLEEAKHKELEEIQSLQEQLSSLTQAHQKALDSLASKAEGLEKSLNSLETKRAGEAKQLAMAQKEADMLRNQLSKTQEELEAQVTLVESLRKEQVLPEFPSQEWELERKELLDTLKHLKEDRADLQATVELLQVRVQSLTHMLALQEEELTRKIQPLDPLEPEFPKKCRSLLRNWRELMVQLKAQDLQHRDSTSQLRIQVAELQEQVTSQSQEQAILQRAQDKTAQVEVERMSTKSLQMELDQAQEARRRQEQQIASAEEQLKFVVGAMNSTQAKLQSTMTRMDQAVARIPSLSNRLSYAVRKVHTIKGLMARKVALAQLRVESSPPSEAAPPLDTDL 479
34 -12.900PF05701.9; W5B560_WHEAT/161-725; Weak chloroplast movement under blue light  ali follow..  70...................................................................................................................................................................................DELETTKRIVEELKHELEKAQMEEVQAKQDSELAQLRVQEIERGVAD--DSSVIAKTQMEVAKERHEKSVAELKSVKEELRTLHEEYASLVNERDRAIKRAEEVLAAGKDIEKRVEGLTVELIAAKGSLELAHAAHHDAEERRIGAVLAKEQDCLAWDRELVQAQEEVQQLNNKLLSQNDLKKNLEANLRKLHGLKSELADYVESILCKEALGVAKEHESEDARQISSSIKETLASTQKELEEVKANIENTKTEAKLLRVAATTLRSELDREKASLDSLQQREVMASIAVSSLEAELNRTQKEIESVRSKEEDAQEKMVELPKMLQQAAQEAEDAKDAA-QAAEEELRKAKEDTEQTKAAATTTSSRLCAVLKEIEASKASERESKEASDVEDSPRGVTLPISEYYALSKKAQDAEELANEKVTEALAQVESVKGSELESLDRLTEATKEMDEKKRTLELALERAERANEGKLAAEQQLRKWRSDHEQ........... 564
35 -12.800PF09730.7; H3DKP7_TETNG/4-712; Microtubule-associated protein Bicaudal-D  ali follow..  11  166...............................................................................................................................................................................KTERELKASLRKELSHYMNIGDALYNSPLSISLDGLKFSEEAATEPNNDEALLGYENGFTKLANAINYDNCVSTPKKELFPPAPSLVDDLLSELNISEQKLKQQLMQMEREKVNLLTTLQDSQKQLEQANGALSEHQDKVNRLTENLNAIRKLQASKERQSALDNEKERDSHEDGDYYEVDINGPEILECKYKVAVSEAGELKEELKTLKAEYQACQSRYEDDRARLENDVTTLGEKLASLEKTSHVDREEKNKLETELRKLRDVAGESQGSLSVAQDELVTFSEELATLYNHVCMCNNETPNEGKGGRSSPEGRGRRSPILLTKGLFPEPGKTDLSDRAPSPVSSLPSPVSDHRREPMNIYNLVAIIRDQIKHLQLAVDRTTELSRQMEEILKLKSLLSTKREQIATLRTVLKANENEKAMVTETMMKLRNELKGLKEDAATFSSLRAMFATRCDEYVMQLEEMQRQLTAAEDEKKTLNSLLRMAIQQKLALTQRLEDLE.. 708
36 -12.700PF15358.4; G1M5D4_AILME/26-577; Testis-specific serine kinase substrate  ali follow..  13  66..............................................................................................................................................................................................................................................................................................................................................................EPTDTSGTDSTTEDSGPLVLPVPPASPTPPWASDDPDITEILSGVNSGLVRAKDSITSLKEKTTRVNQHVQTLQSECSVLSENLERRRQEAEELEGYCSQLKENCRKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQRQLQDETPRRQ--EAELQELEQKLDAGLSRHGLGPTAQSPGCCGPPGSPNEPPRPRSMAPGGWGMGPRAGEGPIVSEQEMQKVSAGLEELRREVSSLTARWHQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQAARGLQELRGRADELCTMVERSAVSVASLRSDLEGLGPVKPILEELGRQFQS. 390
37 -12.400PF05010.12; F6UEE1_XENTR/677-877; Transforming acidic coiled-coil-containing protein (TACC)  ali follow..  11  2..................................................................................................................................................................................................................................................................................................................................................................................................................................SQKDMDAAIEAVRLEVQEKELEVLEWKNKHEKLYLEYVEMGKIIAEFEGTITQMLEDSQRQKEMGKLELSKVLQEKQQVQVDLNSMEKSFSEMFKRFEK----QKEVLEGYRKNEEALKKCVEDYLARIKKEEQRYQALKAHAE------------EKLNRANEEIAHVRSKAKAEATALQATLRKEQMKTQSLERSLEQKSKENDELTKICDDL............................................. 200
38 -12.300PF09787.7; W4YU02_STRPU/423-727; Golgin subfamily A member 5  ali follow..  11  3............................................................................................................................................................................................................................................................................................................................................................................EEAKQELTDYKQKATRILQSKDKLISSLKEGVEGIEGSTAVSYELEEIKNERDMLREELQQANIKIEQLKMDLQEIESLQQMESESLQEQLRDLEDQEIQSRQSLRETEADLARKCEELRYAEEELHRQRLDLQAKIKDREDDIQRLRNQLKTK-SMSSSSETELEGRLHALTESLIQKQTMLETLSSEKNSLGLQLERLQ--RQYKEVQATATPTHTVNIGSYEEEEASTRQRLPLFMQEAPSDGGMTRKVKQAASTIDKFSIRLGVFLRRYPIAR..................................... 276
39 -12.200PF08614.9; K5XJL3_AGABU/10-204; Autophagy protein 16 (ATG16)  ali follow..  6...................................................................................................................................................................................................................................................................................................................................................................................................................IERDATESSFSSVIEQYRRLAQQTKLLKERNATLLRAVGSVKSGQGSSAVSAPASSEENPIRAAYLASLESQISSLRDELATVYKTQGQNAQRLLAMNETLREKEELARLDTENL-RKTKDELAVLRRKVDQHAELMQEKDRTVQILHDEISTLQ------LELGQIEDRNQTLLKDNAKLLQRWLDAKQAEAN................................................................................. 192
40 -12.200PF07058.9; I1Q190_ORYGL/30-591; Microtubule-associated protein 70  ali follow..  11  1..................................................................................................................................................................................................................................................................................................................................................................DEFIALMHGSDPVRVELTRLENELRDKERELGEAQTEIRALRLSERAREKAVEELTDELEKMFEKLKLTESLLDSKNLEVKKINDEKKAAMAAQFAAEATLRRVDDDMPPIEAILAPLEAELKLARQEIAKLQDDNRALDRLTKQKEAALLDAERTVEIAMAAMVDDLQNKNQELMKQIEICHEENKILDKLQRQKVAEVKKLSLTVKEANVVRDYQRQVQEVNDQKKTLECELARAKVTANRVAVVVANEWKDSNDKVMPVKQWLEERRFLQGEMQQLRDKLAVAERTARSEAQLKEKYQLRLKVLEDGLRGPPSGSSRLP.. 340
41 -12.100PF12084.6; E6WG98_PANSA/1-105; Protein of unknown function (DUF3561 topsan)  ali follow..  18  2.QNVTPMLARKDERPQDEPRSSLPGGVIGFLSYWCALAIFLLYGSNTLFFFLYTWPFFLALLPVSVLI---GIVLSLMM--LFWSGVVTAIVVVCLFWLLFS................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 101
42 -12.000PF09789.7; Q16UI1_AEDAE/24-343; Uncharacterized coiled-coil protein (DUF2353 topsan)  ali follow..  10  1....................................................................................................................................................................................................................................................................................................................................................................................................HRKLQSKVEALKIMRNELEKYRSERDQFKLMAETLQMRYSAMKSSLNSPEGHSSAVSLLVNQTRERNISLSTEVEALRQRVHELEGDIDVLRTKNFDLQAAFNKMKSTEETKLRDRKIVWDEEKSKLIAQMETLKKKNAQLQYDVRSLLDEKEDVVMERDAYKCKAHRLNHELSKGDQSQQKIVDVDGLILENKYQQEKITNLENELELSRQSATKYKNMLDTKRKKERGTVEELPLKAATISELKSLCLALLDNVNDKSLALSHQKKTNKLLAAKITELEQRILAL... 320
43 -11.600PF06785.9; Y616_CHLTR/25-425; Uncharacterised protein family (UPF0242 topsan)  ali follow..  61..........................................................................................................................................................................................................................................................................................................................................................................................RRERQLRAAAGQLLEAKIRKLTEQDEGLKNIRETIEKRQKETDRLKLHNDKLVEQLGQAREVFIQAKGRYDHMEELSRRLKEENQQLQIQLEAAVRERNEKILENQELLQELKETLAYQQELHDEYQATFVEQ----HSMLDKRQAYIGNLEAKVQDLMCELRNLLQLEMGAKTNLP--GKPVASRDVVAQLVLEFRKIVFRVETTEAADSLTALRYTRTDPSAHNYSLACRQLFDGLREENLGMLFIYAPFAQ.............................................. 308
44 -11.600PF06496.9; V5SI92_9RHIZ/8-165; Protein of unknown function (DUF1097 topsan)  ali follow..  14  1.................AVSIGLLGGVATYLFLLQIWAAFI-------------WASFYHAGGGTSGFTSSGVLWGAITICVAIGVALMILGAIPA--QVYGFASTVAFTLLTNTAFALTRPDLSNPAIVIASSMVV-----------------GAVFGLVSQKLA................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 157
45 -11.600PF09738.7; LRRF2_XENTR/31-329; LRRFIP family  ali follow..  3.....................................................................................................................................................................................................................................................................................................................................ARLAAKRAARAEARDIRMRELERQQKELDEKIDKQFTENYSRPSSRNATSGIPGTFTPLSGSSSRRGSGDANSSLDPDASLSELRESLAEVEEKYKKAMVSNAQLDNEKSNLVYQVDTLKDVVEEMEEQMAEYHRENEEKSKELERQKHNCSILQHKLDELKEGIQQRDEFIEKHGLVIIPDGTP--------NGDINHEPVVGAITVVSQEAAHVLESAGEGPLDVRLRKLA------EEKEELVAQIRKLKLQLDDERQRSAKNNSTTTDSTGLENGSDLQLIEMQRD---ANRQISEYKFKISKAEQDMTT....................................... 299
46 -11.500PF10498.7; IFT57_XENTR/25-383; Intra-flagellar transport protein 57  ali follow..  110................................................................................................................................................................................................................................................................................................................................................................................................EEVLKHIHFSWKRPTYPTEEQDEENVIEDDAELTLNKIEDEIAEEDSDNDQEHFIDLNALSAQTQKLNTKESSKPEEILESNTDAAEWILEV---ERVLPQLKVTIRTDNKDWRVHVDQMHQHRDGIDTSLKETKGYLDKLHNEVAKALEKVSSREKYINNQLEQLVQEYRSVQAQSEAKERYQQASGGVTERTRILAEITEELEKVKQEMEEKGSSMTD-GAPLVKIKQALTKLKHEIVQMDIRTGVVEHTL......................................... 359
47 -11.500PF10146.7; J9JPB5_ACYPI/20-267; Zinc finger-containing protein  ali follow..  3............................................................................................................................................................................................................................................................................................................................................................................................................KDIRDKTEKLETLKMNILKEIEASDQEDKCLIEYRKELELLLQEKMAHVEELRQIHADINAMESVIKKAEESRNRSMERAKQVHDEYKPLKTDIDLMRRDLLGLERLPELH--------EEESDLVRPDLFVQTYFDKQIKPAVSTPPNSDWHNGDSVQNLTQ....................................................................................................................... 157
48 -11.400PF01540.14; O53101_MYCHO/1-353; Adhesin lipoprotein  ali follow..  1.....................................................................................................................................................................................................................................................................................................MKKSKNIFITLCGIAATAILPVATISCNDDKLAEKNGKEKADAALKQANALVEELKKNPDYSKILETLNKEIAEATKSFKEAGSYGDYPAIISKLSAAVENAKNEKKAIDDKNAQIAKELAERNAKIQSNIEELKKINNEAFELSKTVNKTIAEVEKKFKIEASFKEQLENFADDLLDKSRQIDEFTTVTSTQEGFTLAELESFKEITTTWFNGMKSEWARVLDAWKNELTEINSIIKGVEELKKLSHEISEFSNSVKKTISELEKKFKIDD--KTNKDEAKQFKNELENFADQLLNKSHEIDKFVTVTSAREDFLSELESFKSFNTTWFNEMKCEWARVQEAWKDQLKEIST................................ 352
49 -11.400PF14073.4; H3AGN0_LATCH/55-232; Centrosome localisation domain of Cep57  ali follow..  12  2.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................ILSALKNLQEKIRKLELERTQAEDNLRRLSQETSEYKKVLDKEIRQKDSSKTEVARQNRE----LSTQLAAAESRCTLLEKQLEYMRKMVKNAESERTTVLKQASIGRERSLDHLELQTKLEKLDMLEQEYLKLTATQNIAQNKICLLEQKLREEEHQRKLVQDKAAQLQTGLETNRILL......................................... 178
50 -11.300PF11086.6; A1U0Q4_MARHV/9-160; Protein of unknown function (DUF2878 topsan)  ali follow..  15  1.........................NLLNFILFQAGWACVLYPGLATVGLILVFLGLHLALVS---QQRFSELQFIGFGVVLGGLMDTL---WFRTGVLALDSGEEVLAAPPW---------LIAIWTIFTTLCHSLGWISQRQWLPWALAPIAAYWSASQLGIVALPD............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 134
51 -11.300PF10242.7; TMHS_RAT/25-202; Lipoma HMGIC fusion partner-like protein  ali follow..  14  3..................................VMWGTLTICFSVLVM-ALFIQPYWIGDSVSTPQAGYFGLKTAMFFVALAMFLIIGSIICFSLFFVCNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMEQTGKYTLGHCTI------AFMLAILSIGDALILSFLAFVLGYR............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 178
52 -11.200PF03383.13; O62449_CAEEL/34-184; Caenorhabditis serpentine receptor-like protein, class xa  ali follow..  10  4...........................TVYIYNMIISSSVDIIVMFITFILPVTMT------TINCTFFY----EHPLYLTFLMSIQRIYAVFQPFNQHFTNGKLWGYCAIV-------AIFSWILLLIPFFSHCPVNINQRVFSFAVACQEQNKYLIILPFTTMLLNV............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 151
53 -11.200PF03904.11; YP2A_STAAU/1-230; Domain of unknown function (DUF334 topsan)  ali follow..  13  2.............................................................................................................................................................................................................................................................................................................................................................................................................RKGQLIMSMKDIKNNKENPNTQMNSKSTGTPSSSTQNSLNNEELSELKRQNKLIVKYLAEIQENQKIREKEQKEITSELKEATKDFRDKSLKIRNDFVDVLQEKLKHVDT--------EELKDILGRGIYKVREENDRMLQEVKRSHEHYQTRQKYLFT.......................................................................................................................... 152
54 -11.200PF14089.4; N0AV75_9BACI/12-190; KinB-signalling pathway activation in sporulation  ali follow..  14  12.........VRWGEFAHFFTDYEVGEIISIMFWLMGIGLIFSVLSQMGF-FAYL--LWNRVQIVLIALVLFDLVYFRYSFFAKKGESFIPYVVVAL--FIFVFGLIIAWQKAKQTSKDAFVSALFFMVVITVLEWTLRVNEKSWLYLMLIPLLV--CNAYQLLIL................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 176
55 -11.100PF06637.9; F1MHE4_BOVIN/1-440; PV-1 protein (PLVAP)  ali follow..  51..............................................................................................................................................................................................................................................................................NVHVSTESNLQATERRADGLYGQVVGLTASQANLTKELNLTARAKEAINQMMLSARRDLDRINASFRQCQADRVIYMNNQRYMAAIILSEKQCQEHLKEANKSCDALALTLTQKAKTLEVELAKEKL---VCTKDKDGLTVGKRVAEEQLAECGKTRDQQQQERQLAEDRLRKVQAFCIPLDRN--KFETDLRNLWRDSIIPRTLSTLSFNLYHPLGSELPSIQRACDSLPSIMTSKVEELARSLRAGIDSVTLENEKLQRQKLEVEQSLRASQEAKEKVEKEAQAQAVQAECARQTQLALEEKVALQKERDRLVKELEEKKRETEHLKLQLAVSNSALDTCIKAKSQLTIPGPRPAVPVPNPPPIDPASLEEFKRRILDSQRAPASNVLVSA............... 440
56 -11.100PF15397.4; W5QCZ5_SHEEP/103-360; Domain of unknown function (DUF4618 topsan)  ali follow..  1..............................................................................................................................................................................................................................................................................................................................................................................................................LRNRRTSYQELCDHEDFLTKLSGELIKTIQDTEDGAALKVRMLLQQQDVYTTITDILKKLHQMKCELQEWEEKEESKIHNLEQQVEQLDAQIKKVREQVSFVSTYKDHEYPIKLVQVANLVRQLQQVKDSQLDELDELSEMCRTVLASMSNQIQNKKKNLLRSLVVKIQRANQETLLQKTWNTQVILKYMDKFREFIDRFEEEIPRLRAEMEQLEFQIWEPREIVFADVLLRRS.............................................. 239
57 -11.100PF15771.3; F7CHR8_HORSE/9-582; Domain of unknown function (DUF4700 topsan)  ali follow..  10  32.............................................................................................................................................................................................................................................................................................................................................................................ESSETLSAPLDFGAHLRRPKQSQQNSLESEPSVFTKYQTKPQLFGGDKKDGGLFPLPLSVGKSKGLLEQFEEKKKRAKDRCDSEALYNFISHTRESIYRLQTSVEKSEEHLSSRSQSILDSLETVAKTLQETAQAQSDLVLETAQDKGNMEQAILEMQKRFEARQAEFSEMKSNLKHLEVLVAQQNKDFQQLCEQLNVPSILAELKRLISVPQVPRHVKDSTSQTSPPLAQSLNFTRQDKYASEEPILWQAQALPAARILNRGSLQPGEFGVWGERAKNDTLQKEAALLAVGTGKRNRPVKDKAVQTN..... 342
58 -11.100PF06653.9; Q9TZ35_CAEEL/1-155; Tight junction protein, Claudin-like  ali follow..  12  1..............................MRKVGAIGVLILLGFIFNA-VSVFTDSWLVWSY-YSSSEPTWLAAASWMMFISFGLFFPVILYLHASHKVYHHGCCHSIRHNFNGISLLCSLIVILQAVAFILMAA----NASDYYGSLGYSAYFALVSGILTTIAMSLSGHVSRHD..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 153
59 -11.100PF17045.3; M4AQB6_XIPMA/17-262; Centrosomal protein of 63 kDa  ali follow..  12  3.............................................................................................................................................................................................................................................................................................................................................................................................................................SCEPELQELMKQIDIMISHQRREWQVEKHFLEVRVKNGEEGLLTSKNIIERRDLEIGVLQKQLEEILRSRQEAVAKYEQQLQKLREELDLLKGSY-----------QKLQRKQLKQTSGGAKESDQLKEYQRLSAEWEQQRAQYQ------KQLTTLEAENKSLTEEISHIKSAPWRVEQEHMECCSEVQHLGALLEKARSSLLSQEMELERLRPCEALLGASQPQQLRSDEPDASRGPDQDQQRRGNEAVRLRQLLHAKD.... 246
60 -11.000PF15742.3; F1SF94_PIG/172-554; Domain of unknown function (DUF4686 topsan)  ali follow..  11  1.........................................................................................................................................................................................................................................................................................................................................................................................RPSGDRTKSQPQEELQQLRQDLHRLQVLCSSAEKELRYERGKNLDLKQHNSLLQGESLKIKTELKQAQQKLLDSAKMCSSLTAEWKHCQQKIKELELEVLTQAQSGKSLSSLEEALAREKSNVAAAEEKISDLQQKHKVCLAETCILGKKQLEERIKEAMENEAKIKQNYQEEQQKRKLLHQNNELQNQVKTLQDKERQLKMTNVQQQLRIQQQEAQLKELKNERRLCDEHLKSNQELSEKLSGLQQEKEALGRECGRLLKQLDVHVRNYNEKHQHHKAKLRRVRDHNTNESIETLLEVEC 306
61 -11.000PF09755.7; T1IG88_RHOPR/5-307; Uncharacterized conserved protein H4 (DUF2046 topsan)  ali follow..  11  3........................................................................................................................................................................................................................................................................................................................................................................................................ESDSSSIDGGPIMMPPSPITREQLQKRIESLQQQNRVLKVELDTYKLRVKALQEENRGLRQASVIIQAKAEQEEEFINTLLKKIQALKKEKETLAHHYEQEEECLTNDSRKLTQLRQEKCKLEQTLEQEQECLVNKLMRKIEKLEAETLAKQSNLEQLRREKVELENTLEQEQEVNRLWKRMDKLETEKRTLQIKLDQPVSDPAS--PRDLSNGDTASNLSAHIQHLRGEVSRLRAQLAEHTEKMEKFAKEEKHVKEENLRLQRKLQLEVERREALCRHLSESES. 293
62 -11.000PF15233.4; I3M9X9_ICTTR/45-196; Synaptonemal complex central element protein 1  ali follow..  11  2..................................................................................................................................................................................................................................................................................................................................................................................................SLEPQIEVLINRINEVQQAKKKASEELGEARTVWDALQKELDSLHEEKVHLKEILSKKQESLRILRLHCQEKESEAQRKHTLLQECKERIFALNSQIEEEKNKQRQLRLDFEEQLEALMGQHKDLWEFHRP--EQLAREICTLDSSKEQLLKE........................................................................................................................................... 152
63 -11.000PF02463.17; SMC_BACSU/2-1172; RecF/RecN/SMC N terminal domain  ali follow..  13  1.............................FLKRLDVIGFKSFAE--ISVDFVVVGP-WVLGEQSARSLRGGKMEDIIFLAEVTLTLD-----FLPIDF-----HEVSVTRRVYRSGES-----------FLINNQPCRLKDIIDLFMD----------AFSIISQG-KVEEILSSKAEDRRSKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEKKKELEHVEYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKIQALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETVLKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHSQVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGKKKNNSLLGRSRELEDVTKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRKQQDVKGQLYELQVAEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQKQTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKK. 837
64 -11.000PF16043.3; H3BA08_LATCH/112-317; Domain of unknown function (DUF4795 topsan)  ali follow..  10  1.................................................................................................................................................................................................................................................................................................................................................................................................................................................QCQDAELLNHVQNAILLLQAECEKLNSTAGDLIEDHNKKQDDIDHLYETVEKLEEKKADKEIVDMEIDVKADKFALANKVSRTQFDSTTEQLGKMIQDLLSKMSVQEQDWQKVIEKISTEMECKLDRLEIDPLKKMLEERWKSIRKQLKERSPSYEADE...................................................................................... 159
65 -10.900PF16454.3; A0A087ZTP6_APIME/937-1097; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain  ali follow..  14  2..............................................................................................................................................................................................................................................................................................................................................................................................................................................QDDEIASTTDMANVAQKYIELDKEITDALKEYKELSELYNRTSFEVQLKRQALEAFSEAIKMFEDQMKLQEKYQKEAQPHEISTLTDNAELLKRRLKSLEDSREQLDGSLKEQIAYNRTLEREMHKLKELLQLVRQRDKHLIWLKKNGMKQNKISQLV.......................................................................................... 160
66 -10.900PF10212.7; PPR21_MOUSE/255-771; Predicted coiled-coil domain-containing protein  ali follow..  10  70.............................................................................................................................................................................SITEDTVTVLETTVKLKMFSDHLTSYVRFLRKILPYQLKSLEEECESSLCTPALRARNLELSQDKTMTAVFEKLQTYVTLLALPSTEPDGLLRTNYTSVLTNVGAALHGFHDVMKDISKHYSQKASIEHEIPTATQKLVTTNDCILSSAVTLT------NGAGKIASFFGNNVDYFIASLSYGPKTASGFISPLSAECMLQYKKKAAAYMKSLRTPLAESVPYGEAVANRRVLLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADRLRGTTSAQLPGLAQENATVPIASSQEEAAAKVLTEPVQSTSLVGMLTRTPDSEAPDVESREDLIK---SHYMARIAELTSQLQLADSKSVHFYAECRALSKRALAEKSKETLTEEMRLASQNISRLQDELMTTKR---SYEDQLSMMSDHLCSMNETLSKQREEIDTLKMASK............................................... 517
67 -10.900PF15960.3; Q4V3S3_DROME/9-228; Domain of unknown function (DUF4763 topsan)  ali follow..  10  10..........................................................................................................................................................................................................................................................................................................................................................................................................................DEQEESDLVSSGIDPSDAEEETDLDAAYDELEEMKQRLITLRNKIIITNPDACQDLKIRDPEGGELQELRDQKCQLICQLQEATQHLKDSQNEL---------------KELETWRCHLQLRIHQAKRQLSQFENFKLKVIHQFGLCIERWENQKTCKLDCTTYRKEMAAHILHADNSRKSVVYQKCHKSYRRRIRVELMLVRVFLHNLFEAMVNDFRFFSR.............................................. 219
68 -10.800PF12795.5; Q7MYS5_PHOLL/31-261; Mechanosensitive ion channel porin domain  ali follow..  1.................................................................................................................................................................................................................................................................................................................................................................................ELKQIESSKNPQDAEVAQALQGALNWIADTKSANDRTQKYQTAIDDFPKITKELRQKLLTESDTPRPIPANQP-----IASVEQQIIQVSSRLLEQGGQLQQEQDKGREISDSLVLLPQQQSEARRLLTEASSRLQSLGTPSTPLAEAQFALAQAEVNAHKATVNELEIAQLSANNRQEISRMRVELFK------KRYHRLDLELQQLRSQLNAQRQQKAELALEHTEMLAE............................................................................. 221
69 -10.800PF04108.10; S8BG25_DACHA/15-418; Autophagy protein Apg17  ali follow..  5.........................................................................................................................................................................................................................................................................................................................................................NAKNSLNSVTYCTRGNEIITSTRNALIDASIMASRASFLQNGIKDELKLLQHANTLMENQRETARKGFQTSLGDLDEANHRLDEILSLLRATEVEEAFSTAEKSEQQVQ-DGIENLRSRLRGIIDQVQETDENFESHLEPFTQLIAFITESLGALSKKSAPAIPNPVVAITPSLQSMEDHASVMASLLESLARHYDLCSMALKRAESHDSGVSSQEGDLQTEEDKADMLAVLQRDAGEVDDVVTEIKERLDEMETTSVLVEQTVAHIGDHYRTMLSLLSKMHEGQSSLVNCTIQSKEFVQKQMDNQGVIAERLDELQRLTDHYVLFGEAYDAL 345
70 -10.800PF17098.3; T1JJM3_STRMM/71-267; WTAP/Mum2p family  ali follow..  11  1..............................................................................................................................................................................................................................................................................................................................................................................................................................EATRRENLLVVRLAAKEQEMQEYASQIQELKQSQTPGSSQLRSTLLD-PAVNLMFENMKKELIATKAKLEETQNELSAWKFTPDRWNFAHSLCFPVERVSQASEAGDIVHVPARHYTAALKILNTGKRLMAKCRLLYQENEELGKMISSGRM-AKLEGDLALQKNFSEEMKKSQTELDDFLLELDEDVEGMQSTI..................................................................... 197
71 -10.800PF10226.7; F6QKS9_MONDO/11-201; CCDC85 family  ali follow..  13  1..........................................................................................................................................................................................................................................................................................................................................................................................................................KEDLSKVPDEELLRWSKEELARRLRRAEGEKMGLMVEHGNLMKDVNRRLQLHLHEIRGLKEVNQKLQDDNHELRELCCFLDDDRQKGKKLSREWQRFGRHTAGVLWKEVALSQQKLRELEARQEALLRENLELKEIVLMLDEERSGAGSRSSIDSQ................................................................................................................ 156
72 -10.700PF13851.4; K3WLB8_PYTUL/230-429; Growth-arrest specific micro-tubule binding  ali follow..  11  4.............................................................................................................................................................................................................................................................................................................................................................................................TAHEKAFGEIKNYYNDITHNNLDLIKSLKEEVSEMKKKEAQDEKLMFEISQENKRMSEPLKRALQDVEKLRKNIKVYQEE----RIELRTAKAQLLVLEEEYATLSWEYEVLQQRFAQVQNEYAELNDQFQRSIYDVQQKTGLKNLLLEKKMDAMTIRLEQKDAELNEV----------------LLHAKLEPAIVDRVKGRLDDIMANKNQDLREL................................................................................ 200
73 -10.700PF06717.9; YGGM_ECOLI/14-320; Protein of unknown function (DUF1202 topsan)  ali follow..  19.....................................................................................................................................................................................................................................................................................................................................................KDQFKKQYHGILKLDAITLKNLDAKGNQATWSAEGDVSSSDDLYTWVGQLADYELLEQTWTKDKPVKFSAMLTSKGTPASGWSVNFYSFQAAASDRGRVVDDIKTNNKYLIVNSEDFNYRFSQLESALNTQKNSIPALEKEVKALDKQMVAAQKAADAYWGKDANGKQMTREDAFKKHQQRDEFNKQNDSEAFAVKYDKEVYQPAIAACHKQSEECYEVPIQQKRDFDINEQRRQTFLQSQKLSRKLQDD---WVTLEKGQYPLTMKVSEINSKKVAILMKIDDINQANER.............................................. 307
74 -10.700PF09632.8; YPKA_YERPE/436-732; Rac1-binding domain  ali follow..  1................................................................................................................................................................................................................................................................................................................................................DVRRITPKKLRELSDLLRTHLSSAATKQLDMGGVLSDLDTMLVALDKAEREGGVDKDQLKSFNSLILKTYRVIEDYVKGREGDTKNSSTEVSPYHRSNFMLSIVEPSLQRIQKHLDQTHSFSIGSLVRAHKHLETLLEVLVTLSQQGQPVSSETYGFLNRLTEAKITLSQQLNTLQQQQESAKAQLSILINRSGSWADVARQSLQRFDSTRPVVKFGTEQYTAIHRQAAHAAITLQEVSEFTDDMRNFTVDSIPLLIQLGRSSLMDEHLVEQREKLRELTTIAER......................................................... 288
75 -10.600PF16034.3; U3K4P9_FICAL/415-612; JAKMIP CC3 domain  ali follow..  1................................................................................................................................................................................................................................................................................................................................................................................................................ERERLLRSKKQRRKSLKPPKRHVVETFFGFDEE--SVDSETSSVTSYNTDKTDRTPATPEEDLEDSTPKEEAELRFCQLTREYQALQRAYALLQEQVGGTLDA----------------EREARTREQLQADLLRCQAKIEDLEKALIEKGQDSKWVEEKQLLIRTNQELLEKIYRMEQEEHQLKNEMQDAKDQNELLEFRVLELEERERRSPA................................................................ 196

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Ye Y, Godzik A. Comparative analysis of protein domain organization. Genome Res. 2004 Mar;14(3):343-53.