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Query: PF02463.17; SMC_BACSU/2-1172; RecF/RecN/SMC N terminal domain, from PfamA30U

Results of FFAS03 search in PfamA30U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst FLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAIRWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTRRVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSIFEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEKKKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKIQALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETVLKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHSQVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVKEVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQNSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTVLITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDVTKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQVAEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQKQTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSFLTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMKRLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKRVKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMTKRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNLLSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIVITHRKGTMEEADVLYGVTMQESGVSKLast
1 -323.000PF02463.17; SMC_BACSU/2-1172; RecF/RecN/SMC N terminal domain  ali  100  1FLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAIRWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTRRVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSIFEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEKKKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKIQALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETVLKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHSQVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVKEVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQNSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTVLITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDVTKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQVAEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQKQTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSFLTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMKRLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKRVKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMTKRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNLLSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIVITHRKGTMEEADVLYGVTMQESGVSK 1171
2 -48.700PF13476.4; Q6C910_YARLI/6-233; AAA domain  ali follow..  20  1...KLSIQGIRSFTERETITFNKPLTLIVGQNGSGKTTIIECLRYATGDLPPHSKGGAFIHDPKICGEKEVL----GQVKLAFTNVNGIQMICTRTMQVLVKMASNNGERTTVSTRCAELDAQMPLYLGVSKSILDYVIFCHQEESLWPLSEPAVLKKRFDEIFEALKFT-------KALDSIKSLRKEKNVEIKLQTQTTEYLKADKDRADKAAEKANLLLE.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 225
3 -38.300PF06470.11; Q0UYB6_PHANO/522-635; SMC proteins Flexible Hinge Domain  ali follow..  25  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LPGVHGTIADLLEVPEQYRTVVENAAEGAMFNVVVDDDSVSTKLIDRLIKDKAGRLTFIPLNRIHAPDLN-------LPTRSDMQPLLPKLRYDEQFEDAIRHVFAKIVICPTLDACKSNA....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 114
4 -34.900PF12128.6; Q8EAA0_SHEON/8-1195; Protein of unknown function (DUF3584 topsan)  ali follow..  16......................NGHTNICGTNASGKTTLQRLVPVFYGEYPSRVVPSTRDSFERW-----------------LPHDSSYIIYEYQK--------ADGLLYQAVLASAGDGKGVNYRFIAKGFELSDYRDLKRQGIATTNLLNTREYRAIIQNDRTLLSTGSNRSERQFALCDGEHSLRHIEKLMETVKSMIAAILEEDGVNPPSSRLNPQ-AWIRESQLIQGFEVIRPEFEKLEQEFNQLLSAEMRLSSLSRGYRNDESLEADRLEIQQTLSKELNLKLRMLDDEWKEVRDE---LNLDLSAAKGDVAKCEYELDAIEDQHGAFLEQAKADLDMLPNWRADMENLSERHKLQTEKHQDIEAAYNARRSKIGEQLNRELEGLHSEQDKQR--EARDKQREVARGDLDALEAQWRSQMDAGKASFSEQEYQFKLNAAELKLRVDGVTYTEEEKLNLAIFDERIHRADEEQESCNAKVERLTSDERKLRAKRDQANEALRIASLRVNERQTALDELHHMLFPQSH-----------TLLEFLRKEAQGWEQSLGKVIAPELLHRTDL----------------------------------HPSVTGESDTVFGVNLDLKAIDVPEYAASEQELRIRLSKAEEAL------------QSAQELQAEAESQLVAINGELDKLSRELTFARTAYKNSRDDLRRLFDEKRSEQDKINKLAERKAFAQQRLTQLDGELKQLKHQHQLWLEEQKEIGALDNQLGQIKATIDARRESAKAEQKACETWYKNELKSRGVDEDNILKLKQQIRELETKISRAEQRRSEVLRFDDWYQHTWPKLQTQLSDVKRAASEIDQQLKAKTQEVKTRRQQLETERKASDAAQIEASENLTKLRAVMRKLAELKLPANSLGERLRQGEDLLLKRDYLMGSVKQYVEHFDSVIASKSGSGLAETWERAREESSINDKGIRLLDYRKLVPQLEQLLNVIVPQSMALREQGRIFGVDLTAFYDVLADIDRRIASQSARITREVGEEVSESAVRIRSKISELIGRAALTGGISK--RLKEGNSDLIIR---RQLNESS--SHGMAYLILCKFLLAFTRL-----WPIDEL-GTLHHTNVKK----IFDACGNNNISVLG........................ 1167
5 -31.700PF01576.17; G3Q6K2_GASAC/841-1921; Myosin tail  ali follow..  12  109.............................................................................................................................................EQQLDQEEGARQKLQMEKVTTDAKLKKLEEDVMVLDDQNNKLLKEKKQMEERISEFTTNLTEEEEKKSLQKLKNKHEAMITDLEDRL---VRQELEKNRRKLEGDSSELHDQMSDLQAQIDELRAQLAKKEEELLAALSRIEEEAAAKNAAQKQIRELEAQISELQEDLELERQARAKAEKHRRDLGEELEALKTELEDTLDSTAAQQELRSKREVEVTHLKKSLEEEAKIHEQQMADMRQKHNQAFEE---LNDQLEQAKKNKMSMEKAKQALESEWNELQIEMKTLTQGKGDSEQRRKKAESQVQELQVKYSESERQRQEVAEKITKMQSELEHVNSLLSEADNKNIKFSKDISATESQLQDAQELLQEETR------QKLALSTRLRLVEDEQN-----NLREMLEEEEEGKKNVEKQITT-----------------------------------LQAQLADMKKKLENE-----------LSVEGAEEGRKRSQRELEGVMQQLEEKTAAYDKLDKTKTRLQQELDDLLVDQDHLRQIVSNLEKKQKKFDQMLAEEKTISTQYAEERDKAEAEAREKETRALTLARELETLSDVKNELDRANKMLKAEMDDLVSSKDDVGKSVHELERSKRAMDQQLEEMRVQVEELEDELQATEDAKLRLEVNMQAMKAQFDRLVKQVREMEVDLEDERKQRSHALSAKKKLELDLGELEVQIEAANKGRDEALKQLKKLQALMKDQMRELDELRLSRDEAVNGAKETERKLRAMEADALHFQEDLATAEKVKKQVQAERDELQEEISSTNTKNSVLAEDKRRLEARITQLEEELEEEQLNTEMVNDRLKRSVLQTEQMTTELAEERSGSLRLEGARSQLDRQNKEMKLKLQE............................................................................................................................................. 956
6 -31.300PF15921.3; G5BJQ7_HETGA/1-1111; Coiled-coil domain-containing protein 158  ali follow..  10  86.......................................................................................................................................................................QVKDLQRRLNESNELHEKQKFYLRQSVINLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMMENSSTQIEQLRKVMLSHEGVLQEIWTILVDFEEASGKKIHEQDNMSTMPFR-TLKAESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMCHLSELESTVSQLRSEL----EAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDMGNSITIDHLRRELDDRNMEVQRLEALLKTMKECQGQMEQQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELT-----AKKMTLENSERTVSDLTASLQEKE-----------------------------------RAIEATNSEITKLRSRVDLKLQELQHLKTEEEHLQHAQTECEALRLQ--------------MAGKDKVIEILRQQIENMMQLVGQHGRTAGAILVEKAQLEKEINDRRLELQEFKVLKDKKDAKIRELEAKVSDLELEKVKLVNAGSERLRAVRDIKQERDQLLNEVKNSRSELNNLSEDYEVLKRNFRKLKMQLKSAQSELEQTRNTLKSMEGADGHAVKVAVGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDVKELQGPGFTSNSSMKPRLLQPASFTRTHSNVPSSQSTASFL-----------HHSRKTTALKEDPTKDLKQLLQELRSVINEEPTVQLSK............................................................................................................................................ 926
7 -27.800PF05483.10; SYCP1_RAT/28-813; Synaptonemal complex protein 1 (SCP-1)  ali follow..  12  4.....................................................................................................................................................DSNYFKTVNKCTEGDFGVPLTMSSLSKNRENIDTDPAFQKLSILPMLEQVANSGSCHYQEGVNDSDFENSEPMSRLYSKLYKEAEKIKKWKVSIESELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHWCNLLKETCARSAEKTSKYEYEREETRQVYVDLNNNIEKMILAFEELRVQAEEMHFKLKEDHEKIQHLEEEYQKEVNNKENQVSLLLIQSTEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELNEKKDHLTSELEDIKMSMQRSMSTQKTLEEDLQIATKTIYQLTEEKEAQMEELNKAKTTHSVVTELKATTCTLEELLRTEQQRLENNE-----LKLITMELQKKSSELE-----EMTKFKNNKEVELEELKTILAEDQ---------------------------------LLDEKKQVEKLAEEL-----------------------------------------------------------QGKEQELTFLLQTREKEIHDLEVQVTVTKTSEEHYLKQVEEMKTELEKEKLKNIELTANSDMLLLENKKLVQEASDMVLELKKHQEDIINCKKQEERMLKQIETLEEKEMNLRDELEEFIQQGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKSKNIEELHQENKALKKKSSAENKQLNAYEIKVNKLELELASTKQKFEEMINN---YQKEIEIKKISEEKLLGEVEKAKATVDEAVKLQKEIDLRCQHKIAEMVALME------KHKHQYDKIVEERDSELGLYKNREQEQSSAKVALETELSNIRNELVSLKKQLEVEKEEKEKLKMEQENTAILTDKK............................................................................................................................................ 786
8 -27.500PF05911.9; U5GNM3_POPTR/17-877; Filament-like plant protein, long coiled-coil  ali follow..  11  6.........................................................................................................................................................KQHAKVAEEAV------SGWEKAEAEALALKNHLETVTLSKLTAEDRASHLDGAKECMRQIRNLKEEHEQKVQDVVLNKKKQLDKIKMDFEAKIGNLDQELLRSAAENAALSRSLQERSNMLIKISEERSQAEADIELLKSNIESCEREINSLKYELHVTSKELEIRNEEKNMIMRSAEAANKQHTEGVKKIAKLEAECQRLRGLVRKKLPGPAAL-AQMKLEVESLGRDYGDSRLRRSPVKPPSPHLSSVPEFSLDNVQKFNKENEFLTERLFAVEEETKMLKEALAKRNSELQASRNLCAKTASKLQSLEAQFQINNHQKSSPKSITQVPAEGYSSATTSVSDVSHFKKDNHIEKSNKAENAKHLELMDDFLEMEKLACLNADSATTISSSPNNKASETANTDALAEVSLQKEDALSEEKRDLDPLANHVSCNKDSSAINSGSDADLSSFGKLQSRISMLLESVSKEVDVDKILEEIKQVVHDAETAASCGSKEVHHSD---ATCDRQTCPEDAVIMGEKEITLLQESIIHDFVLLLGKEAMAVHDTSCDSIGLSQKIEEFSITFKKVLCSDRSLIDFMFDLSRVLALASG------LRFNVLGYKCNEAEINSPDCIDKVALPENKVIQNDSPGETFQNGCANISSPTSNPEPDYGNLVPGYGSNTTSCKVSLEEFEELKSEKDTMAMDLARCTENLEMTKSQLHETEQLLAEVKSQLVSAQKSNSLAETQLKCMAESYRSLETRAQELETEVNLLRVKTETLESELQEEKTSHQDALTRCKELEEQLQTKESSSADGIDLKSKQEKEITAAAEKLAECQETIFLLG-------KQLKYLRPQTEIM........................................................................................................................................................................ 861
9 -23.700PF10174.7; H2T771_TAKRU/113-856; RIM-binding protein of the cytomatrix active zone  ali follow..  12  1.............................................................................................................................................QAQLRN-LQRENDNLRRELDRG----RSCSTNNVNFWSPEVKRDKGVRREEGVRSLKDQYRSNHEDLQQLPLTVELQEELRAHREMNSRLQHQRQQGNSGSYPPPLDPSEENFLRLQSDHERQAKELLLLRKTMEEMETRIDSQKQTLDARDESIQRLLELLQGQGQGTWSRGHRAGIITMAAQEAEAHQENMELQRRTQPQAEPAKTRALQAVIDMKDTKISSLERNIRDLEDEVQMLKTSGLLQPDDRQDELKQVEVYKSHSKFMKMKIEQLKQELNKKESEMQALQTKLETLTNQNSDCKQHIDVLKESFSAKEQRANTLQTEVDALRVRLEEKEQFLTKKTKQLQDLTDEKSTLTGEIRDLKDMLDVKER----------------------------------------------------------------------------------------KVNVLQKKIENLLEQL---------------------------------------------KDKDKQLAGLRERVQGFQTDSSNTDTALATLEEALSEKERVIENLREQKETRLEELDQMRKENQELKDKLTALQPPKELKEFSLVDLMCSSQAVFTLLTSTPIKDLDVWSHHKSAAMKNSGLIQNTEEATRKCADITDRLRLLEQEVARNREDSRKSKAEVERLMLALREAEMEKLSKEKKIADLESIAYTLFHLKREGLHVLSKDNSWFKKAQGTEEKAKLGLNSLLEQLEELMGALEKTRQELDTTKLHLSSTQQSLHERDRHLNSLHQDRRKQLQEILEMKQQALLAAISEKDANIALELSSSKRKKAQEEVMAL--------REKDRLMHQLKQQTQSRMKL................................................................................................................................................................. 744
10 -21.500PF07111.10; CCHCR_MOUSE/27-758; Alpha helical coiled-coil rod protein (HCR)  ali follow..  10  2....................................................................................................................................................................................................................................................APTWASDVPLVQSPASQDVLERRLDAQRSTVTTWGQDFCGDGQGL-RGRSLELGFSSALSQQAELISRQLQELRRLEEEVRSLRETSLQQKMRLETQAVELDALAVAEKAGQAEAEGLRTALAGAEMVRKNLEEAKHKELEEIQSLQEQLSSLTQAHQKALDSLASKAEGLEKSLNSLETKRAGEAKQLAMAQKEADMLRNQLSKTQEELEAQVTLVESLRKYVGEQVLPEFPSQEWELERKELLDTLKHLKEDRADLQATVELLQVRVQSLTHMLALQEEELTRKIQPLDPLEPEFPKKCRSLLRNWREKVFALMVQLKAQD---------------------------------HRDSTSQLRIQVAELQEQV-------TSQSQEQAILQR------------------------ALQDKTAQVEVERMSTKSLQMELDQAQEARRRQEQQIASAEEQLKFVVGAMNSTQAKLQSTMTRMDQAVARIPSLSNRLSYAVRKVHTIKGLMARKVALAQLRVESSPPSEAAPPLDTDLSVELEQLREERNRLDAELQLSAHLIQQEVGRAR---EQGEVERRRLIEVAQQLEQELQRAQESLASVGQQLEAARRGQQESTEEAASLRQELTQQQEIYGQALQ--EKVAEVETRLREQLSDTKRRLNEARREQAKAVVSLRQIQHKATQEKERNQELRRLQDEARK------EEGQRLTRRVQELERDKNLMLQRLLAVLPSGVNKKCSPRSVESSSSESPAAASCKESVKGSLTVLLDNLQGLSEA............................................................................................................................................. 716
11 -21.000PF09730.7; H3DKP7_TETNG/4-712; Microtubule-associated protein Bicaudal-D  ali follow..  3.......................................................................................................................................................................AYTNHRKVAADGESREESLIQESACKEAYYEQRVLELQNDLRQARNLVANAQS-----------ENDRQNALSQEIKDHSQMVELQRNQLRDDIKEYKLLEARLLQDYTELEEENITLQKQVSVLKQSQVEFEG----LKHEIRRLEEDTQFLNSQLEDAIRLKEIAERQLGEALETIKTERELKASLRKELSHYMNIGDALYNSISLDGLKFSEEAATEPNNDEALLGYENGFTKLANAINYDNCVSTPKKELFPPAPSLVDDLLSELNSEIQKLKQQLMQMEREKVNLLTTLQDSQKQLEQANGALSEHQDKVNRLTENLNAIRKLQASKE-------------------------------------------RQSALDNEKERDSHEDGDYYEVDI-----------------------------------------------------------------------------------------------GPEILECKYKVAVSEAGELKEELKTLKAEYQACQSR---YEDDRARLENDVTTLGEKLASLEKTSHVDREEKNKLETELRKLRDVAGESQGSLSVAQDELVTFSEELATLYNHVCMCNNETPNMLDFYKEGKGGRSSPEGRGRRSPILLTKGLFPEPGKTDLSDRAPSPVSSLPSPVSDHRREPMNIYNLVAIIRDQIKHLQLAVDRTTELSRQRVASLELGTVADKDKEACMEEILKLKSLLSTKREQIATLRTVLKANKQTAEVALANLKSKYENEKAMVTET-----------------MMKLRNELKGLKEDAATFSSLRAMFATRCDEYVMQLEEMQRQLTAAEDEKKTLNSLLRMAIQQ-KLALTQRLEDLE................................................................................................................................... 708
12 -20.600PF05701.9; W5B560_WHEAT/161-725; Weak chloroplast movement under blue light  ali follow..  10  1.............................................................................................................................................KGLIDT--AAPFESVREAVTKFGGIVDWKAHKVQMMERRKFIQLELENAQKEIPKCKEELEAAEMAKSQVLD------------------ELETTKRIVEELKHELEKAQMEEVQAKQDSELAQLRVQEIERGVADAKTQMEVAKERHEKSVAELKSVKEELRTLHEEYASLVNERDRAIKRAEEVLAAGKDIEKRVEGLTVELIAAKGSLELAHAAHHDAEERR----IGAVLAKEQDCLAWDRELVQAQEEVQQLNNKLLSQNDLKKNLEANLRKLHGLKSELADYVESILCKEALGVAKEHESEDARQISSSIKETLASTQKELEEVKANIENTKTEAKLLRVAATTLRS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELDREKASLDSLQQREVMASIAVSSLEAELNRTQKEIESVRSKEEDAQEKMVELPKMLQQAAQEAEDAKDAAQAAEEELRKAKEDTEQTKAAATTTSSRLCAVLKEIEASKASERLALAAVRALNESKEA-----SDVEDSPRGVTLPISEYYALSKKAQDAEELANEKVTEALAQVESVKGSELESLDRLTEATKEMDEKKRTLELALERAERANEGKLAAEQQLRKWRSDHEQ.................................................................................................................................................................................................................................................................... 564
13 -20.300PF05557.11; G3PW04_GASAC/52-714; Mitotic checkpoint protein  ali follow..  10  1..................................................................................................................................................................................................................AAEKVQSKNRYLQLDQEKRQME-LSHKRARYELERAASDSARDFEHEVDRNQDLLGRIKKLEERETEEAKNLSEQVEVNRSLRKNLDGLNRKVEERDTRLNTANQTISSLKDEIRELKQKIQNQDSAVSSHTLENQELQEHLDLQRRKYQEVSQLCQSLQAAQSSCSEHIIT--IKELERRLALQEQDFAIVKNIKSEVARVPDLERDLKRLREDNAFLRESRENCS-LLKEEVEGLRKKLERTERTKEELVNMELEKERVAEKLRAWETIGQSTGLNIRKPEDLSREVI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------HIQQIEISLKEQNYTLNSRVRSAERSQAELRAELSKQRGRTQEEQKKREAQDALVRRLQKRVLLLTKERDGMRAILESYDGELAQLSKRLREAEEVLQRTQKHNVEMEGQLTKAQEEAGTLKLQLHAVELEMESLRKQQASGDGSSSETKEEVSILRQKIEDLEAERQSLEQQNNVLEMRLERHNLQGDYDPVKTRVLHLKMNPTATAKQQRQQDGEALREEVTRLREVVRSDESGLSLPPPKEVLGSFLCNHNLVNLRKQMESSELRNQRLKEVFQ----------RKIQEFRTVCYVLTGYQIDITTENQYRLTSL--YAEHMDDSLLFKKMGSNGAKMQLMETEFSKTLGEMVA--HLHHQKSLPAFLSAVTLDLF........................................................................................................................ 659
14 -20.100PF15070.4; W5MC41_LEPOC/402-1036; Putative golgin subfamily A member 2-like protein 5  ali follow..  11  1...................................................................................................................................................................................................QLMESVQQLKTERDQYAAQLQEEGKVWKDRTEQLLSQVNSLSEEKERSMTQIQELENLVIELRNASALLSQEREDQAAPEPTPSENETALQEALGKLQQEKDDLSTQYQAQVRDNEQLSRLCQEQEERLLELERTVQRFSEDAVDRQQILESMQSDKATISRALAQNRE--------LKEQLAELQNGFVKLTNENMELMSALQSEQHVKKELAKKMGQMQEELHQSREELEGKTQEARSLLEQRDQYLAHLQQYTAGYQQLVAEREELHKQYLHQVQLMDRLQHEEVQGKVQLELSQKELERAK------EKLTQLAKDNESLKTEVKELTGLGTQPRDQGDGV------------------------------------------------------------------------------------------------------------------------------------ESKSPAESFQKASIAIPEDFDSREEMAAFLQSALSQVEREWDEVSRLYEEEQRLHQAALQQVAALRSEHQHHSTAAAGPAGDGVP-VEVHEALRAAMEKLQSRFTALMQEKADLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAIMKQRHMEKEHYISMLAKDKEEMKAKLAELQDLVLRLVGERNEWYSKYITSVSNPDLLPSSSVEPSAPAERRIELNATDGPEAPELSSLEAAPEGDLSGQAGQPPRPQEDGTARQIM........................................................................................................................................................................................................................................... 595
15 -19.500PF05622.10; H2QW41_PANTR/12-710; HOOK protein  ali follow..  13..................................................................................................................................................................................NVDAPCQTVEDLTNVMAQVLQKIDPNRIKTEVGDNWRLKISNLKK--------ILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAE-NQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEID-VLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEE--------------------------------------------------------------------------------------------------------------------------------------SKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLALNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLE----EHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLD--PKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKK-AAEDRLASTGSGQSFLARQRQATSSRRSYPG............................................................................................................................................................................................ 699
16 -19.200PF07888.9; CACO1_DANRE/5-593; Calcium binding and coiled-coil domain (CALCOCO1) like  ali follow..  11  4......................................................................................................EFRNVGSCYFPQSRDCHYND--------GLFKVGWSSVKE-QASYLPGPSAQQYQFVYVDGKGEICSCSAAFTFSAPKPLEELVTLEEEGQGEEVGEDMLLVIPRAQLLQSRLQECLKERAELLQALEAADQNVEREKGRRERDRGSWEHTRKELERKIDDLKEEVREYREKVEDMKKKQKEVEDLGEALTEEKRALLAQKEANEQRIRELEEDIKILTQRGLERETDLERMRERAKKSAAQKREDEDEHKNLKLKMEQTEKEL----HSLSAEFQSLRSSLAQRDTHALQLRDTITTLTHKLNSAHRKEAANELA----LNELRSVQERLNVSEHCVETLRGELRDMVAQRDSAHAELHQARLQAAQLTLQLADASLALREGRANWA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QERETLQQNAEIDKVRLERQNDEIQQKEEMLQKARMEREKAVVELGREKDCNRELKASLRVAQKEKEQLQTEIQEVMEYSRQLERRLEVLSDCKWSETALLQSSRAESPLLSDSEDENPEALQDTHSSGPLNHYSLCEQPQSDLLLPATPPPSPRHPSTVVISQPAPLSSPHQPSAR............................................................................................................................................................................................................................................................................................................................... 589
17 -19.000PF15964.3; SDCG8_HUMAN/6-706; Centrosomal colon cancer autoantigen protein family  ali follow..  10  13.............................................................................................................................................QRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNEDARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKM--------SPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFG--KAASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVG-GLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALI------------------------------QCDQLRKELERQAE-----RLEKELASQQEKRAIEKDMMKKE------------------------------------------------------------------------------------------------------------TKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQLQAQQREQELTQKIQQMEAQHDKTENEQYLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL................................................................................................................................................................................................ 700
18 -17.300PF04310.10; MUKB_ECOLI/2-227; MukB N-terminal  ali follow..  15  6.FRSLTLINWNGFFART-FDLDELVTTLSGGNGAGKSTTMAAFVTALPDLTRNTTEAGATSGSRDKGLHGKLKAGVCYSMLDTINSRH------QRVVVGVRLQQVAGRDRKVDIKPFAIQGLPMSVQPTQLVTETLNVLPLNELKDKLEAMEGVQFKQFNSITDYHSLMFDLGIIARRLRSASDRSKFYRLIEASL--YGGISSAITRSLRDYLLPENS....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 225
19 -16.900PF13555.4; Q0A6A1_ALKEH/19-80; P-loop containing region of AAA domain  ali follow..  27  1.LQRLEVFNWGTFHDRVSLQPGGDNSLLTGDIGSGKSTLVDAITTLLVPAQRITYNKAAGAE..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 62
20 -16.200PF04849.11; H3AF28_LATCH/123-428; HAP1 N-terminal conserved region  ali follow..  11  1...........................................................................................................................................................................KEGVPHYTLRADTIFGYDHDDWLHTPLLPPEANLELTPEQIEETLKYFL-----------LCSERVGRVTKTYHDIEAVSHLLEEKERDLELAARIGQSLLKQNQSLTEKDEYLEEQLQLAKEEIAQLRHEIAMRDDLLHVYTNTAEESESSSTVSTPLRRNESSASLQHYIHLDFLQEKLRGLEEENQKLRSEATDMVTETVDFEEQEQQLMIDCVQELAEANREVGMLSEELARKTEDILRQQEEISQLLAQIVDLQQKCKSITTESEELSQHLALSRERQEQLRLELKDLQEKHAEYKELLQETREENKNLRNK........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 306
21 -16.000PF00261.18; I3J233_ORENI/12-247; Tropomyosin  ali follow..  11  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RKIQCLQQQADDAEDRAQVLQRELDSERELREKAEGEVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAELSECKASDLEEELKNVTNNLKSLEAQSEKYSEKEDKYEEEIKVLTDKLKEAETRAEFAERTVAKLEKSIDDLEEKLSHAKEENLGMHQVLDQTLQELN..................................................................................................................................................................................................................................................................... 235
22 -14.800PF15818.3; G3T452_LOXAF/26-1066; Coiled-coil domain-containing protein 73 family  ali follow..  10  2.....................................................................................................................................................................LLDFKTSLLEALEELRMRREAETQYEEHIGKIIVETQELKWQKETLQNQKETLAKQHEEAMAVF----KQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKLSEMEQKVQLHFLAKEDHHKQLNEIEKYYAIITGQFGLVKENHEKLERNVQEAIQLNKRLSALNKKQEFELCSLKKELKKVTSDLIKSKVTCQYKMGEENTNLTIKERKFQELQERLNMELELNKKINEEISRIQEEKQNVIISFQHMQQLLQQQTQANAEMKAELKVLKENNQTLERDNELQREKVRENEEKFLNLQNEHEEAQGTWKKVEELNGEINEIKNELSSLKETHIKLQEHYNKIYDQKKFEEDKKFQNVPEVSNEHSRMSAEKSEDTT--------------------------ILTYNSGQEIREENSMNFCSDTEYREKKEGPPKEEI--------IIEDLQLLEKSCKNEIITTVPQDE----------------------NQSEISLSKVLCTDKEVISQGQTLNVPDFRKSITTEIKDKLCLEKDNGCTEFQSPTSLILVADTSIETKMIHLESMGGLDSHHPDVHLEAENHRSCDSILNDNTNHSKDVSENEPFKQQFRLLPCTQKSTAERVMTNTDQTKAELDSLDVKEKPVHWEKCSLHNSSSVMLDDKRCKTKQLLRTQSECGILPLKQTSDFQQLCNDTSEKAQLNIPCDTASSYPISYAAFSDNLKLLENSDKKVSIVPMLVKPNSSPGKRTTRKNLDAQSSQFKDCLERLENNMTIPHLQIDNENIHASQPKDMKTAVYRKTSTEIQLSSKDSQIDENQITEATKNDNNTEKTESLNDIVSQLEESRSFHIKASGDSVNTS-----------GMSAFDLSTSDKKTE--LNFLDPGTWSKVNQIE----SQTVSTSASSILSSPKERPI---IVSTTVVRPDTTSINRVADTLNNSS--------IHPKGEPSEERNATAKTFYDSS... 968
23 -14.700PF06818.13; H3A1M8_LATCH/446-647; Fez1  ali follow..  11  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KWEVCQKSGEISLLKQQLKDSQVELAQKGNEILSLKAQLRGVRAELQACEDQLQELQEAAHTKTLELEVCENELQRKKNEADLLREKVGKLEREVAGLREMVARSRQSQEQEDAFLLYESDEAKAQRQNADTLLGLRQQVERLKAELLYERRRSEDQLEGFEEERRTWHEEKEKVIRYQKQLQHNYIQMYRQNRELEREMR........................................................................................................................................................................................................................................................................................................ 202
24 -14.400PF04582.10; Q9DPB5_9REOV/1-326; Reovirus sigma C capsid protein  ali follow..  12  6..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PLQRREVVSLILSLTSSTTTNPGDLTAVYERLTNLEASTKSLRQSLSSIVSDLSDVSVDLQDTTRALDDAIATLKGLNTTVAALQNSVASLSSTVNGLTDISSAHSEALSFLRTTIDGNTVAISNLKGDVSTNGLNIADLQNRMKSLESSTSHGLSFSPPLSVADGVVSLDMDPYFCSQRVSLTSYSA-EAKLMQFQWMAKGTSGSSDVIDMTVNAHCHGRRTDYMMSSTGGLTVTSNAVSLTFSLDYITNMPSDLSRL.............................................................................................................................................................................................................................................. 263
25 -14.200PF09728.7; W4Z3B2_STRPU/161-468; Myosin-like coiled-coil protein  ali follow..  11  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HMSRAIMQALNGLETPEDKIAALCKKYAELLGEHKSLQRDSKTQTKQLSQIQRERDHLQSEHGRALLAKSKLESLCRELQRHNKTIKEESLQRAREEDEKRKEVNKFQQTINEITTQMQDNHTRNIKLKEENIELASKLKNLVEQYERREEHIEKLFKHKDESQLYDAKLQQSNLALAEEKERNKREKELLIAESVDSKRRLEMFTKQEAQLKAQLAVYTEKFEEFQSTLTKSNEVFQTFKQEMDKMTKKIKKLEKETNLWRGRWETSNKSLMTMVEEKGRHEKDMSDKLIKINRLEKLCRAL............................................................................................................................................................................................. 305
26 -14.200PF15358.4; G1M5D4_AILME/26-577; Testis-specific serine kinase substrate  ali follow..  11  1.........................................................................................................................................................ESRSQLVPEAPGGVTTPAKGITKKKKAVSFH----------------VEP-RMSHEPMHWCLNLKRSSACTNVSLLLAAMEPTDTSGTDSTTEDSGPLVLPVPPASPTPPWASDDPDITEILSGVNSGLVRAKDSITSLKEKTTRVNQHVQTLQSECSVLSENLERRRQEAEELEGYCSQLKENCRKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQRQLQDETPRRQEAELQELEQKLDAGSRHGLGPTAQSPGCCGPPGSPNEPPRPRSMAPGGWGMGPRAGEGPIVSEQEMQKVSAGLEELRREVSSLTARWHQEEGAVQEALRLLGGLGGRLDGFLGQWERAQ------REQAQAARGLQELRGRADELCTMVERSAVSVA----------------------------------------------------------------------------------------------------------------------------SLRSDLEGLGPVKPILEELGRQFQSSRRGSDLSMNLDRPPQGSCGRCASQGPQLSTESLQQLLERALTPLVDEVKQRGLAPACPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEALRAKNLLLTDKMKPEEKVATVDYLHLKMCSLHDQLSNLPLE........................................................................................................................................................................................................................................................................................................................................................... 527
27 -13.800PF10481.7; G7NUK3_MACFA/1-307; Cenp-F N-terminal domain  ali follow..  11  2...............................................................................................................................................................................SWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQF------------------QLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCSTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQTTMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQKTPIRRDFCSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLEQLKVQNQELRSKINELELRLQGQEK..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 306
28 -13.700PF14915.4; G1KGA5_ANOCA/157-457; CCDC144C protein coiled-coil region  ali follow..  15  5..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QDELSVLRLELDRIRIQHQEQESK---YLEENEALKEKIEELKLNEDALTQTVFQCNGQINISKTEAAMLTTKLEHIKEHKERLEMEINSFHSRLNSTAQELERCQLGKNDAERVLQRERDEWIR---LKDKLNHDICTLREASNTMSQQLSKSESKANGLENELHQVTYTLREKSLLLESCQRDLNQAQGQVKELENARQAEKDQMNKYIVKHDSMQERLAQLQSENLLLRQQLEDFQNKSIIKEKVVTDVQDRFNDIFSKLRSDTEKQVQLME------ERNKELVTKCDNQREQVLKYEAEKADR............................................................................................................................................................................................. 300
29 -13.700PF13166.4; Q63PW4_BURPS/9-780; AAA domain  ali follow..  11  37............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GKTTLSRIIGAVITNNNIPAQGHDIRVYNKDFVDEHLAFLRDE-QGHISPFAVLGSKNKEIEVEIDKLEDELGSVENKTGLRHSYQEKKKAHADKKKAAQDAQDELDKKIFDKANKNPTGIKHNSKLDIKTVQDKKIAPLDDADRSSKVKLLSEVALPDIEKRLSFNSSLPALAKSTVELITKKIKPSAPIQELPLPADLWKRLGDHFNQESQDLEKDLDSVLTKISNEKTRIKNVSANQATFDNLKADLDDAINNHEKSLQSLEDELNA-RKKDIFTERSTIDVQDNTVSISQKVSLVNELIERNNKTTTSLEEDQKIARNELRLSEISQFTIDIDLAGEEKKIKALEDQITKAKDELDAV--------AEGKKRVDRVKELRTQLRDEKRGAEQVNQYLGHF----------------------------LGHGGLSLSAVEEANTATYRFQILRGDQAAYN---LSEGEC--SLVAFCYFLAKLEDILIIYIDDPISSLDSNHIFFVFSLIENYITKPQLFISTHN...................... 622
30 -13.400PF15934.3; B3MK61_DROAN/489-722; Yuri gagarin  ali follow..  10  2........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LKEIADLICKLRSTDFSYNEIYNETSTENPFCVAIMEMFDEKSEQTEKEYESLAANERLVCQISALKETLNDRNELINHLQSMIGNYMSENNRLKEENHDLKMKNSENIRKAREIAEQLNGQVTQRVELVNKYESLSSSFEEQCQELKGANRRVQSLQTRLCQVEKLQEELRTERKMLREEVIALKEKDACSVGRERALQDQLRCSQMDLDKSRCLIRNMQSQLQQQDKL..................................................................................................................................................................................................................................................................................... 233
31 -13.300PF15905.3; HMMR_MOUSE/15-339; Hyaluronan mediated motility receptor N-terminal  ali follow..  12  13...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KTSEATKGPVSFQKSQRFKNQRESQQNLNIDKDTTLLASAKKAKKSVSKKDSQKNDKDVKRLEKEIRALLQERGTQDKRIQDMESELEKTEAKLNAAVREKTSLSASNASLEKRLTELTRANELLKAKFSEDQKNMRALSLELMKLRNKRETKMRSMMVKQEGMELKLQATQKDLTESKGKIVQLEGKLVSIEKEKIDEKCETEKLLEYIQEISCASDQVEKCKVDIAQLEEDLKEKDREILSLKQSLEENITFSKQIEDLTVKCQLLETERDNLVSKDRERAETLSAEMQILTERLALERQEYEKL............................................................................................................................................................................................. 321
32 -13.300PF07058.9; I1Q190_ORYGL/30-591; Microtubule-associated protein 70  ali follow..  10  1..................................................................................................................................................................................................................................................................DEFIALMHGSDPVRVELTRLENELRDKERELGEAQTEIRALRLSERAREKAVEELTDELEKMFEKLKLTESLLDSKNLEVKKINDEKKAAMAAQFAAEATLRRVHAQKDDDMPPIEAILAPLEAELKLARQEIAKLQDDNRALDRLTKQKEAALLDAERTV----EIAMAKAAMVDDLQNKNQELMKQIEICHEENKILDKLQRQKVAEVKKLSLTVKELEEAVLRGGATANVVRDYQRQVQEVNDQKKTLECELARA--------------------------------------------------------------------------------------------------------------------------------------------------------------KVTANRVAVVVANEWKDSNDKVMPVKQWLEERRFLQGEMQQLRDKLAVAERTARSEAQLKEKYQLRLKVLEDGLRGPPSGSSRLPTEGKSFSNGPSRRLSLGGADNMSKLSPNGLLARRSPSFHSRSSLSSSSSLVLKHAKGTSKSFDGGTRSLDRSKINGNGA-HLLNRSTDAVRDCETNDSWKGNADEGTIENTNSNTDESNKETANNKSAEMVSGFLYDMLQKEVISLRKACHEKDQSLKDKDDAIEMLAKKVDTLTKAMEVEAKKMRREVA-AMEKEVAAMRVDKEQEVKARRLGSSKGTGSS.............................................................................................................................................................................................. 560
33 -13.200PF09311.9; F6RFI5_XENTR/524-830; Rabaptin-like protein  ali follow..  11  2...............................................................................................................................................................................................DMCSNYEKQLQGIQTQEAEIRDQVKKLQS----MLRQVNDQLEKTLKDKKDLEDYMKQNTEETSTQISTLTIRTNQSETLADLQQAFTQAKRNIQDQMAVLMHSREQVSEELLRLQRDNESLQGKHSLHVSLQQAENFSLPETSEELQKYREDIISVRTAADHLEEKLKAEILFLKEQIQAEQCQKENIEETLQIEIENCKEEIASTSSLKLELDRVKAEREQLEASLQEKTRALQNLQTLKDSLEDQLKKETGGKASLEQLVFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQTD................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 307
34 -13.100PF05667.9; CCD22_AEDAE/1-553; Protein of unknown function (DUF812 topsan)  ali follow..  11  250................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SKGGTKHRLAEPSGAAASSGTTEKVVLNNITVETKPGKTPLESLQEEIDALQQEIVQHSEEGVQLESSRKETDESIEEYRKTIVRLKEEKKIKERTHILLEDPEVNVKKLEAIIAAGGERMKKLQDQWDAHRIPLVDTLEAYRLKNSDKLSKSQQVLDQIESTRQKCEEVVIDLQTKGAMYARLQKEFEKLNKTVSR-----TAYTSRILEIIGNIRKQKNGIDQILQDTRSLQKEINNITGQLDRQFTVTDDLIFRNAKKDEHSKRAYKLLVT------SDCEELIKLVQETGAIKREVRDLEDQIENE............................................................................................................................................................................................. 550
35 -13.100PF06637.9; F1MHE4_BOVIN/1-440; PV-1 protein (PLVAP)  ali follow..  12  18...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SRGCWYYLRYFFLFVSLIQ----VYGNVHVSTESNLQATERRADGLYGQVVGLTASQANLTKELNLTARAKEAINQMMLSARRDLDRINASFRQCQADRVIYMNNQRYMAAIILSEKQCQEHLKEANKSCDALALTLTQKAKTLEVELAKEKLVC---TKDKDGLTVGKRVAEEQLAECGKTRDQQQQERQLAEDRLRKVQAFCIPLDRDLRNLWRDSIIPRTLSTLSFNLYHPLGSELPSIQRACDSLPSIMTKVEELARSLRAGIDSVTLENEKLQRQKLEVEQSLRASQEAKEKVEKEAQAQAVKLQAECARQTQLALE------EKVALQKERDRLVKELEEK--------RETEHLKLQLAVSNSALDTCIKAKSQL.......................................................................................................................................................... 396
36 -12.700PF14662.4; H9GPA1_ANOCA/135-325; Coiled-coil region of CCDC155 or KASH  ali follow..  14  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EEAADLMNSIKDLQQGNKQLAVQNTKLQRTIETAEELNSRLSEEISELKGKLRSTQEQARAVANELEDLKVFSKTLEEENNRLHAQTRQLEKEQQLLFVRVDNLQEENKKLLTEKENSKCKIKELFTKKASLKSKICEYEKLTSCKDAALNEKTKRIEELTMILDEYRTVVEELRLEVRRLQDHLCQ..................................................................................................................................................................................................................................................................................................................... 190
37 -12.700PF17078.3; SHE3_CANTT/23-265; SWI5-dependent HO expression protein 3  ali follow..  13  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TKVIDSLHSKIDELTDELTTLKQSHQELTKKHSIVAKKNDSFVDQLANAKHENDMLSALLKRKERRILDLEDQYNDLNSQIENLSLSNKNMKIRCENLQNNSNASIAEFERLKISYDALIASQMEYKNHYQQELNTLQT------SFDKYRTENTKRYEDLQSSISSNDKDIDTLLDSLTNKRKTMDNIYVNKNN------KILQLLTSLASLIKLHAEDTKGQVEQNVDVIKILMEKYPDLQEKILEKEKVEV................................................................................................................................................................................................................................................... 243
38 -12.600PF15742.3; F1SF94_PIG/172-554; Domain of unknown function (DUF4686 topsan)  ali follow..  12  12..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QEELQQLRQDLHRLQVLCSSAEKELRYERGKNLDLKQHNSLLQGESLKIKTELKQAQQKLLDSAKMCSSLTAEWKHCQQKIKELELEVLTQAQSGKSLSSLEEALAREKSNVAAAEEKISDLQQKLEHGKKQLEERIKEAMENEAKIKQNYQEEQQKRKLLHQNMNELQNQVKTLQDKERQLKMTNVQQQLRIQQQEAQLKELKNERRLCDEHLKSNQELSEKLSGLQQEKEALGRECGRLLKQLDVHVRNYNEKHQHHKAKLRRVRDHNTNE-----IETLLEVECSDIVKCEPPKNEEEKEFQKQVIAQNDTLSLEKRKLREQLVRQEGIIDKNRWMLSSVQKRVLFLDQENKH............................................................................................................................................. 375
39 -12.500PF09738.7; LRRF2_XENTR/31-329; LRRFIP family  ali follow..  10  24..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ERQQKELDEKIDKQFTENYSRPSSRNATSGIPGTFTPLSGSSSRRGSGDANSSLDPDASLSELRESLAEVEEKYKKAMVSNAQLDNEKSNLVYQVDTLKDVVEEMEEQMAEYHRENEEKSKELERQKHNCSILQHKLDELKEGIQQRDEFIEKHGLVIIPDGTPNGDINHEPVVGAITVVSQEAAHVLESAGEGPLDVRLRKLAEEKEELVAQIRKLKLQLDDERQRSAKNNSTTTDSTGLENGSDLQLIEMQRDANRQISEYKFKISKAEQD................................................................................................................................................................................................................................ 296
40 -12.400PF10168.7; I3KZS6_ORENI/8-718; Nuclear pore component  ali follow..  421.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VEHILCTRPLLTSQSAPIRGFLIVSDLALGATMICITSTYECILLPLLSSIRPPSPPLLCSHPGLGSASSPLRGLAEDSFEQHIRNILARSSTNPLVLKAGDKDTSPPPPECLELLSRATQVFREEY-----ILKQDMAREEMQRRVKLLTGQKNKQLEELSLCREERKSLREAAERLADKYEDAKYRQETIMNRVKKVLCSLQSQLPILSNSEKEM----------KKELQTINDQLKHLDNCIRQVNMKMEYQKTQV---DKDMPGTRARVSLNAPQKKVVQDVLKEQGQQIGDMMKQIKDIKNHFS..................................................................................................................................................................................................................................................................... 711
41 -12.400PF08614.9; K5XJL3_AGABU/10-204; Autophagy protein 16 (ATG16)  ali follow..  1..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LRLRLIERDATESSFSSVIEQYRRLAQQTKLLKERNATLLRAVGSVKSGQGSSAVSAPASSEENPIRAAYLASLESQISSLRDELATVYKTQGQNAQRLLAMNETLREKEELARLDTENLRKTKDELAVLRRKVDQHAELMQEKDRTVQILHDEISTLQLELGQIEDRNQTLLKDNAKLLQRWLDAKQAEAN..................................................................................................................................................................................................................................................................................................................... 192
42 -12.300PF06008.12; LAMA1_HUMAN/1575-1831; Laminin Domain I  ali follow..  11  5..............................................................................................................................................................................NLTGIIPVPYGILSNLENTTKYLQESLLKENMQKDLGKI------------------KLEGVAEETDNLQKKLTRMLASTQKVNRATERIFKESQDLAIAIERLQMSITEIMEKTTLNQTLDEDFLLPNSTLQNMQQNGTSLLEIMQIR--DFTQLHQNATLELKAAEDLLSQIQENYQKPLEELEVLKEAASHVLSKHNNELKAAEALVREAEAKMQESNHLLLMVNANLREFSDKKLHVQEEQNLTSELIVQGRGLIDAAAAQTDAVQDAL.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 257
43 -12.200PF15254.4; G1T8F1_RABIT/39-892; Coiled-coil domain-containing protein 14  ali follow..  11  246.......................................................................................................................................................................................................................KEADLLKCFQTYMSLFQSHGKETHPDNQTYQSPTRSQQAFLASSEDKDAREQIGESTSEGKDLNIHKQDAK--------------------MVKDVQKAKNVNQTAEKVTTIKYFLGELKALVAEQEDEIQRLITEVEACVSELPAVSGNTNI-QVEIALAMQPLRSENAHLRSRQLRILNQ-RLREQEKTKKTTGSVECNLELFSLQSLNMSLQSQLQESLKNQELLQSKNEELLKVIENQKDENKKYTSIFKEKDQTILENKQQFDIEITKI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIELEEALVDVKSSKFKLDTAEKENQILGITLRQRDAEVARLRELTRTLQNSMAKLLSDLSVDSARCKSGNNLTKSLLNIYDR--QLQHDPAPAHTSIMSYLNKLETNHSVAHLEPLSTIKNEETTEPDRPYENVLPSKGPQPRNTSGREEEPASGIISALSKQDSDAENETLTVIEDECNLDSTV---YIPFVRSTSKMNSPLSKRLSPQPQMSVAITQLVGNSGLVSETEKKLCAHAVTCSSRQEVEDAHEKLSRTADTEDKQLLKKIKEAIGKIPVAREDPEATCQGPSACHKSSIRVKGSTACDGSVLNSDLMSDWSISSFSTFTSLDEQDFRNGLAALDANIARLQKSLRSGLLEK........................................................................................................................................ 854
44 -12.000PF09787.7; W4YU02_STRPU/423-727; Golgin subfamily A member 5  ali follow..  11  1...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SAEEAKQELTDYKQKATRILQSKDKLISSLKEGVEGIEGSTAVSYELEEIKNERDMLREELQQANIKIEQLKMDLQEIESLQQMESESLQEQLRDLEDQEIQSRQSLRETEADLARKCEELRYAEEELHRQRLDLQAKIKDREDDIQRLRNQLKTKSMSSSSETELEGRLHALTESLIQKQTMLETLSSEKNSLGLQLERLQRQYKEVQATATPTHTVNIGSYEEEEASTRQRLPLFMQEAPSDGGMTRKVKQAASTIDKFSIR................................................................................................................................................................................................................................ 264
45 -12.000PF09789.7; Q16UI1_AEDAE/24-343; Uncharacterized coiled-coil protein (DUF2353 topsan)  ali follow..  10  1................................................................................................................................................................................HRKLQSKVEALKIMRNELEKYRSERDQFKLMAETLQRYSAMKSSLNSPEFQ--FGHSSAVSLLVNQTRERNISLSTEVEALRQRVHELEGDIDVLRTKNFDLQAAFNKMKSETKLRDRKGIVWDEEKSKLIAQMETLKKKNAQLQYDVRSLLDEKEDVVMERDAYKCKAHRLNHELSVMLKGDQSQQKIVD--VDGLILENKYQQEKITNLENELELSRQSATKYKNMLDTKRKKGIIKLGTNNRVMSHSQVKDLLERGTVEELPLKAATISELKSLCLALLDNVNDKSLALSHQKKTNKLLAAKITELEQRILAL....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 320
46 -11.200PF15324.4; H9GLI0_ANOCA/127-1404; Hedgehog signalling target  ali follow..  10  1...............................................................................................DIFISQ--YDAGQKEAVRAVFKQRVKEVKVQLLGSHSEMDSAATIA--KVQSDFEAKVSSVSKILNKLQETDRRLQLAVERQSSLKAPTRERSPCHQRFGELEKQMHLFMEQR------LRNLENFQQQQMNIQSHLISSPQDLLAARAVHMQACSRPFGSHAVHRQKSPLNTPAPRRYAPVPVSRDAKISQKMSKREPPVGEKENMHQPAYGTTVGGGKLLEQILNSQETPASQDT--YSLKESSGNNAVLWPFERECRSSVQEPEPFCAFKSTNQNLNPVERTVQKAGDVLRDLGQLKREMHDILQDAKEWKSDMNKFMKTTAHPGEAIQAKDRLPQSQSSSSLLPSSEAFLPMPPPAENYTVAPTLRELQQLSKSSILQSTQASKSIRDAEKILRAVQKNKKLLEENLEAIIRAKDG-------VLEEIRIRKTVDEWIK-AISMEIQDEMERTDSLKRQ..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 524
47 -11.200PF09731.7; F1MXX0_BOVIN/42-730; Mitochondrial inner membrane protein  ali follow..  184..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QQAIVAQNAAVQAVTAHANILKAAMDDSEIAGDKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKEVAGAKSHITAAEGKLHNMIIDLDNVVQKVQAAQSEAKVVSQYHELVVQAREDFKRELDSITPEVLPGWKGMTDKLSA-DDLNALIAHAHRRIDQLNRALAEQKATEK------QHIALALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRAAAHTDHLRDVLRVQEQELKYEFEQDLSEKLAEQELQFR-RLSQEQVDNFTLDINTA---RLRGIEQAVQSHAVAEEEARKVHQLWLSVEALRYRMKTASADLPTVLGSAVEAIRASAQALTAAL------------PPESLTRGVYSEET---KLARRVAMIDETRNSLYQLSYLQSLLLFPPQ-FTLLSYASYCLEHGDLELAAKFVNQLKGESRRAALKEARVTLETRQIVEILTAYAS.... 689
48 -11.200PF13514.4; D8PEH4_9BACT/1-216; AAA domain  ali follow..  17  3.LARLLLFAFGPFTNKT-LDFSVGLHVIYGPNEAGKSSALRAMT-----------------DLRF-GIPLRSPDDFVHPAGDLRIGGVFIDQTGRPVGLIRRKGRGTTL----PGFTVDSGLERELT--GGLDRQEFE-LNHARLRELLNGEGDLGSALFEASAGTSGIAALLAALDTDAKKLYSQHGRINEARRQLDEQRKAWREAQTKPAEW............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 216
49 -11.000PF04094.12; Q7XPH2_ORYSJ/208-1047; Protein of unknown function (DUF390 topsan)  ali follow..  13  422..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EEGRRSVDAMVEVGRKAHRRHISELEARKAALAEIAREVEEEREAALIATTAMIEAQDSLRQHGSWEAELKKKLDAAQGVLDAAAAREQRATEAKAACRQREEALEARAMALEDHAGAVEISLADREAAAAIREVTLAAHEAACAEEESALRLREDALAERERALEESEAATQRLTDSLSLRKAAQEEQARRNLECIRAEREAREKELDARERSGGAATGESDLVARLAAAEHTVADMQRALDSSTGEAEALRLLGEIGPGMLWDAVSRLDRAGREAGLWKGHTISHSTNLEGLAPHLRRMAWAVQRLPEELEKTIKS-QGAVELVLASYQARDPGFSPWMALEEFPPGTEDDARARVRDAANHIVQSFEGSAPRL------AFAPSSDEEGDASGED--AGDPG............................................................................................ 839
50 -11.000PF09726.7; H2MT57_ORYLA/2-679; Transmembrane protein  ali follow..  13  30YLKFLVVWALVLLAD-LEFRFE-----YLWP-------------WLFIRSVYDSFRYQGLAFSVF----------FVCVAFTSD----FIPVQWSTYVWVQYVWHTERG-FVYIEAAIRFKDLKNFHVD------GYPVVTLGGFKSYVSYKMRLRKQ-----------KEVQKENEFYMQLLQQALPPEQQMLQRQEREAEEAAKGASEVETLPVTQNGAPPNK-----KTSVPLPELEYREKGKDGRGGGEAKKQHNSNNILQPSLDSKIHEMEYMENHMNKRLTTELDSTESLLLKEDNNSSCSSSSSSSSKNYKNASSNAAALNSSPRGHSTTNGSVAFSASSSTTNTAKNDKKHKLPVGKGTAGGSHKDPADNWIPNNQLSKPEALVRLEQDIKKLKADLQASRQVEQDLRSQISSLGSAERSIRTELGQLRQENELLQNKLHNAVQAKQKDKQTVGQLEKKLKGEQEARATAEKQLAEEKKRKKLEEATAA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------RAVALAAASRGECTDTLRRRITELETECKKLTMDIKLKEDQIRELEIKVQELHKYKENEK-DTEVLMSALSAMQDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQMIQKDQEIKDLKQKIAEVMAVMPSISYTTDTSSMTPVAPHYSSKFMDTSPSGLDPNASVYQP.............................................................................................................................................................................................................................................................................................................................................. 677
51 -10.900PF03429.11; B9KHR1_ANAMF/1-756; Major surface protein 1B  ali follow..  3............................................................................................................................................................................................................EDDKQQQQNQSDVVQAISA--------VFQRKSAELQRLNDFIKGADGTLKNVHPHMKSLEALSKQLSEKIAAEAAAKADAKYESVGLRAKAAAALGNLGRLVARGKLKSSDAPKDLDQSIDALPFMDEAPDTGEKIEVPAGEEQEFGKAAAWGLAGFKRTVDESLEMLDRGMHMLAEGQAQISQGIDAKDTAL--VREGLETSRLGAGLCRNGLVEASYGVGYANETMGKYAGKLDKCKNKLDNACHKWSKALEEIESLRTAIDAKAEQQVEGEAWSPEGVSANTFYKGLHKIGTAIAVAAQATWEGLAMTGKFMGAVAKLAGAVSMCVAAYTAAIVGMAAAT-PATLLLTAMDNQSVNN----------------------------------AVVKVSEYLHSNVEQATKDLMASEFAMMTFGGIMTCAKLMKGSFAAIEINATLTREATDIAQGVKETYQSIGDAFGNAFKSVGDAFKSIGDAFKSANDGIAKWTAALAGYASVEQLEEAKEADRGERAATVAAGTETIKTIVSDMRNELAKGHEQLQLVITDMCNELAQIGAFSQAERDALVKSFTPKPPARTTKELISHMHSGLESVMFRMARSKASIEANSQDNSVEVAEISPETQNMSDAIPVEEAQIVETALLAAVNDTSKDDQAIVTDLINATIEVCTEQTNTLAGHTAEVQAGLEAAGIRFDDAQGLQEATPEAKGVEGINQEELEQAAEGLAAAVNEASADGKMQSLNQQETQIAQGEQQQQQSS........................................................................................................................................................................................................ 752
52 -10.900PF06160.10; R7G8R1_9FIRM/22-573; Septation ring formation regulator, EzrA  ali follow..  121...............................................................................................................................................VLDDILEQENEQRVHINA------TFRKVKKTIHENRTAYSQSYEYLETEIIAIEKMFSKFEEWMFAS-EFNKAADQQKEIKITRLNEIVEALPSLYERAKGILPRAIDEVGYNYARAKNVSKNLDVISDMLKNDLNRLHSGT--PENVKEDLDDLEVRIAQLAEQIRLEEEAFDEVNDGLTALFDSIREVNCEFDDIKSLYARVYERFTQRLQDTQTRLDVLNDMQRRLDKIVLDKQVPYTTILIAYKELAQSNAGFSKEVELMKEKLNNACSDEERAKKQLIKLQLIINEIRVKMLKHR---AQYEKDLCKGEDMMHDVRDILEHSPLDVTQLNAKLREAIDFIYTLYNNVNNLVGMAIMVENTIVFGNRYRSSCPEIDSELTRCEQYTKALKIGI-QCIEKM............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 542
53 -10.900PF10146.7; J9JPB5_ACYPI/20-267; Zinc finger-containing protein  ali follow..  3............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KDIRDKTEKLETLKMNILKEIEASDQEDKCLIEYRKELELLLQEKMAHVEELRQIHADINAMESVIKKAEESRNRSMERAKQVHDEYKPLKTDIDLMRRDLLGLERLPELHEEESDLVRPDLFVQTYFDKQIKPAVSTPPNSDWHNGDSVQNLTQAHQHAQAAVAAFLGS............................................................................................................................................................................................................................................................................................................................................. 172
54 -10.800PF04111.10; W1QBV0_OGAPD/127-441; Autophagy protein Apg6  ali follow..  13  8..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................STLIDELKQQFEQMTKEKDTYVQFLKKLTAQSGPNRKKAQDSLSELALLKEEETKLLEELEKAEKEEEQLTQQLVEVEQELEDLENQEKEFCLQKNAYDLELIEFVNERERIKASYEYNLNRLDSLRKTNVFNDVFMISHDDQFGTINGLRLGNLDNVKVSWHEINAALGQLALLLATVVR............................................................................................................................................................................................................................................................................................................................ 188
55 -10.700PF01540.14; O53101_MYCHO/1-353; Adhesin lipoprotein  ali follow..  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MKKSKNIFITLCGIAATAILPVATISCNDDKLAEKNGKEKADAALKQANALVEELKKNPDYSKILETLNKEIAEATKSFKEAGSYGDYPAIISKLSAAVENAKNEKKAIDDKNAQIAKELAERNAKIQSNIEELKKINNEAFELSKTVNKTIAEVEKKFKIEASFKEQLENFADDLLDKSRQIDEFGFTLAELESFKEITTTWFNGMKSEWARVLDAWKNELTEINSIIKGVEELKKLSHEISEFSNSVKKTISELEKKFKIDDKTNKDEAK---QFKNELENFADQLLNKSHEIDKFVTVTSAREDFSLSELESFKSFNTT---FNEMKCEWARVQEAWKDQLKEISTK................................................................................................................................................ 353
56 -10.400PF06785.9; Y616_CHLTR/25-425; Uncharacterised protein family (UPF0242 topsan)  ali follow..  46..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LFPVVSSLGWLFAIGRRERQLRAAAGQLLEAKIRKLTEQDEGLKNIRETIEKRQKETDRLKLHNDKLVEQLGQAREVFIQAKGRYDHMEELSRRLKEENQQLQIQLEAAVRERNEKILENQELLQELKETLAYQQELHDEYQA---TFVEQHSMLDKRQAYIGNLEAKVQDLMCELRNLLQLEMGAKTNLPG---KPVASRDVVAQLVLEFRKIVFRVETTEAADSLTALRYTRTDPSAHNYSLACRQLFDGLREENLGMLFIYAPFAQRVLFANALFNDWTGYGLEDFLNRES-DVVLEGFAQWERDLLTE............................................................................................................................................................................................. 350
57 -10.300PF13779.4; D7A9C0_STAND/55-942; Domain of unknown function (DUF4175 topsan)  ali follow..  12  429.....................................................................................................................................................IGRSRPRTFVLPERSFSNPLARALIDERRVLAFDANQRERVEAGLDALAIAPEKFTPDPS---HYMGLRSAYWRLANAKSDEDLRGVVAYLWEIAVRIEDGDRDAQQALQNALENNASDDEIKRLTQELREAMQEFMQALAEEAQRNAQADSDQPMGPNTRMVRPQDLQKMLDRIEDMARNRDAARQMLSELQNMLNGLQAGRQQQRRQGQNQMSQAMDQLGDMIRRQQQLRDRTFKQGREQGQ-QGQQGQQDQRFGDLKQSQEQLREQLRQLREKMQQAMRGRQQGQGEQGQQGQGEQQGQNGQGQQGQQGEGQQGQGMPGEGGLGEAEQAMREAEQALGAVDAQSEALQALRKGAQQMAEAMQQ................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 809
58 -10.300PF04108.10; S8BG25_DACHA/15-418; Autophagy protein Apg17  ali follow..  5...............................................................................................................................................................................NAKNSLNSVTYCTRGNEIITSTRNALIDASIMASRASFLQ------------------NGIKDELKLLQHANTLMENQRETARKGFQTSLGDLDEANHRLDEILSLLRATEVEEAFSTAEKSEQQVQRSLFD-DEDGIENLRSRLRGIIDQVQETDENFESHLEPFTQLIAFITESLGALSKKSAPAIPNPVVAITPSLQSMEDHASVMASLLESLARHYDLCEDKADMLAVLQRDAGEVDDVVTEIKERLDEMETTSVLVEQTVAHIGDHYRTMLSLLSKMHEGQSSLVNCTIQSKEFVQKQMDNQGVIAERLDELQRLTDHYVLFGEAYDALLVEVGR---------------IAVQRQKDSIIQEALAKIDMLNEGDLNEREQFRSEF----GDYLPSDI................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 396
59 -10.200PF06317.9; L_TACVF/1-2207; Arenavirus RNA polymerase  ali follow..  10  36..GSLLQEGFKLLSNLVELE----------SHACHLNTCQKYVDVILSDHGI----CPTLPKVIPDG----------------------FKLTGKTLILLETFVRVNPEEF-WKSDMTKLLNLKQDLLRSGIGRTNYRFTPEWVVERILRKSRSSAEIDIEDQ----EY-QRLIHSLSNVRNQSLGFENIECLKRNVKGDVRESVIREELMKLRLWYKGKFRITNRSELLNNLIRLGKHEDNTTSDCPFCVNKFMDIIYSLTFTALKRQDREKSNSELDQYVVCPHEKAYLGVLSICNKIKGLKVFNTRRNTL-DLFTAKPEALDSLRRSGLILGQMVTLVNDRALDFLEAVKLIKKKIETNVKWVENCSKILRRSQQDIWSQISVWARYP-----DLSKLISIAQTISSDRPIMRYSAGGNFNTECKHKTFHMMSDAEQVEAFKILSSVSLSLINSMKTSFSSRLLINEKEYSFYQKTGERSGCYSIYTCEDGVLVEKGSFYCDPKRFIFSQEVLVEMCDEMTTWLDFNSDLMVISKEKLRLLLLSILCAPSKRNQVFLQGLRYFLMAYSNQFHHVDLLSK------------------LKVECMSGSEVIVQRLAVDLFQCLLGEGVDSDPYFARRFKYLLNVSYL---------------------HLITKETP-DRLTDQIKCFEKFIEDFNCVIVNPSLNGQLTEAQEGMMLDGLDKFYSKTLKDCSDTKLPGVSNELLSYCISLFNKGKLKVTGEKPNITSTALDLSSNKSVVVPKLDELGNVLSVYDREKMISSCVSSMAERFKTKGRYNIDPSTLDYLILKNLTGLVSIGSKTQRDCEELSMMFEGLTEEQAEAFNDIKNSVQLAMVKMKDSKSGDVNLSPNQKEGRVKSSTGVKDFDPDVLASDLYKELCDVVYYSSSKPEYFLERPLEVCPLGLLLKNLTTSAYFDEEYFECFKYLLIQGHYDQKLGSYEHRSRSRLGFTNEALRVKDNSEAIADKLDRSYFTNAALRNLCFYSDDSPTEFTSISSNNGNLKFGLSYKEQVGSNRELYVGDLNTKLITRLVEDFAEAVGSSMRYTCLSSEKEFD----AICDMKLAVNNGDLSCSLDHSKWGPTMSPALFLTFLQFLELRTP............................. 1213
60 -10.200PF10498.7; IFT57_XENTR/25-383; Intra-flagellar transport protein 57  ali follow..  10  26...................................................................................................................................LSRHYFAL----------PTNPGEQFYMFCTLA-LISKAGHHFDQPQEYDDPNATISNILSELRSFGYSVD-CYVLDCFAEEVLKHIHFSWKRPTYPTEEQDEENVIEDDAELTLNKIEDEIAEEDSDNDQEHFIDLNALSAQTQKLNTKESSKPEEILESNTDAAEWILEVERVLPQLK------VTIRTDNKDWRVHVDQMHQHRDGIDTSLKETKGYLDKLHNEVAKALEKVSSREKYINNQLEQLVQEYRSVQAQLSEAKERYQQASGGVTERTRILAEITEELEKVKQEMEEKGSSMTD-GAPLVKIKQALTKLKHEIVQMDIRTGVVEHTL............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 359
61 -10.200PF17045.3; M4AQB6_XIPMA/17-262; Centrosomal protein of 63 kDa  ali follow..  13  1..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LSSCEPELQELMKQIDMISHQRREWQVEKHFLEVRVKNGEEGLLTSKNIIERRDLEIGVLQKQLEEILRSRQEAVAKY---EQQLQKLREELDLLKGSYQKLQRKQLKQTSGGAKESDQLKEYQRLSAEWEQQRAQYQKQLTTLEAENKSLTEEISHIKSAPWRVEQEHMECCSEVQHLGALLEKARSSLLSQEMELERLRPCEALLGASQPQQLRSDEPDASRGPDQDQQRRGNEAVRLRQLLHAKD............................................................................................................................................................................................................................................................. 246
62 -10.100PF10212.7; PPR21_MOUSE/255-771; Predicted coiled-coil domain-containing protein  ali follow..  1................................................................................................................................................................................................IAGQALAFVQDLVPALLNFHTYTEQRIQIFPVD------AIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKMFSDHLTSYVRFLRKILPYQLKSLEEECESSLCTPALRARNLELSQDMKTMTAVFEKLQTYVTLLALPSTEPDGLLRTNYTSVLTNVGAALHGFHDVMKDISKHYSQKASIEHEIPTATQKLVTTNDCILSSAVTLTNGAGKIASFGNNVDYFIASLSYGPKTASGFISPLSQYKKKAAAYMKSLRTPLAESVPYGEAVANRRVLLSSTESREG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADRLRGTTSAQLPGLAQENATVPIASSQEEAAAKVLTEPVQSTSLVGMLTRTPDSEAPDVESREDYMARIAELTSQLQLADSKSVHFYAECRALSKRLALAEKSKETLTEEMRLASQNISRLQDELMSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMASK........................................................................................................................................................................................................................................................................................................ 517
63 -9.980PF11398.6; Q6D3T4_PECAS/1-377; Protein of unknown function (DUF2813 topsan)  ali follow..  15  2HLESIEILGFRGINR-LSLTL-DENNVLIGENAWGKSSLLDALSLLLAPTLPL--YHFDMQDFHFTPGDENSREKHLQIIFTFCETAPGHHLSPRYRSLSPVWVEGNESLYRV-----FYRLEGEVDESQSVFTWRSFLDADGHPIPLDNIDELAREII-------LHPVLRLRDARFMRRLRSGTAATLDNSNEKLAQQFEQLIRELVQNPQKLTDKELRQGLV.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 212
64 -9.920PF17097.3; KRE28_ZYGRC/1-362; Spindle pole body component  ali follow..  12  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KSDLDGYEVRIKSLENQTAHYSEQAQRVLASLREITQNVIAMGQENSLVEIKGELESKEESELVIDPSGFQEKIDTFVELVELLKVTHLEQETLDNFLRYTISSSNLLQINSVQDAKYVEQVKELEQGTLESHKREIEATKGQIKNLCQELSMAQDSINETFLDTSNALEECDALLNELTQLRMEKQTSEEADTIEDDPVSQTYEDWESLQKELRLLEEETSRLQSRVESYEDYQKRSRQLSNNDPRMLQNHKALELLVELWMTKFLPQP-SHLELFPQSRKFQFDVEPTFTVVITLADQTTFQNVQVYRKDAKSLVMDHGLNDEIKNSYLGTNNIYNGLNDIIHTLQR.................................................................................................................................................... 362
65 -9.920PF08317.9; B6HCL6_PENRW/924-1250; Spc7 kinetochore protein  ali follow..  13  69.......................................................................................................................................................................................................................................MLELYQHSCRELKSYISEGRQVIRSIEAETYAENPALFK---EYVTAPPDIRVIMDNQFRNVKTHARLLSKATWYEWRMKLLEGLKEGLLRHVEEMKADDDLLSEREELLNRNVPLLVEKHASLEQEATNLQQLVDEMENCDQDELRSTRSKLSEVDSEIAAKRRELEQLQEEVKEKVTFIEAGAEMRDEFLAQIQEAERVKEECRGWSAREINELKASVQRIQQ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 290
66 -9.860PF15771.3; F7CHR8_HORSE/9-582; Domain of unknown function (DUF4700 topsan)  ali follow..  13  1....................................................................................................................................................................GNTKSSNWNSNQTD-LFGSQFCPESSETLSAPLDFGAHLRRPKQSQQNSLESEPSVFTKYQTKPQLFGGDKKDGGLFPLPLSVGKSKGLLEQFEEDSEALYNFISHTRESIYRLQTSVEKSEEHLSSRSQSIDSLETVAKTLQETAQAQSDLVLETAQDKGNMEQAILEMQKRFEARQAEFSEMKSNLKHLEVLVAQQNKDFQQLCEQLGQL--NVPSILAELKRLISVPQVPRHVKDSTSQTSPPLAQSLNFTRQDKYASEEPILWQAQALPAARILNRGSLQPGEFGVWGERAKNDTLQKEAALLAVGTGKRNRPVKDKAVQ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 340
67 -9.840PF15290.4; M3ZY07_XIPMA/184-491; Golgi-localised syntaxin-1-binding clamp  ali follow..  38.............................................................................................................................................................................................................................................RYKRVSLGRYRSCEDNHGVRPPNPEQYLTPLQQKEVAIRHLKTKLMESENKVHDRENEIQEFKSQLCRMREDWIEEECHRVEAQLSLKEARKEIRQLRQVVETMKNSLMEKDKGIQKYFIDINIQNRKLESLLHSMELAQSGSALQDEGALDFMCDGP------EGGGKKLMGEEDGGLEMGNPGAEAMADSGLLVNDEMANREDIFEKVFMSTAADFSQDSSSSQGLPVASPPNALSSTVTISSNAPCHQNTDDKEVQTDFPSISADLQALLLQ................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 306
68 -9.820PF05478.9; F1S5C8_PIG/18-820; Prominin  ali follow..  162..................................................................................................................................................................................................................................................ANQHMRTKAGEVKHFTTMAVNLGTAFIILAKQIDYIAEQYTTTKERVFSDLDNIKVLLGSYQQLKPKLIPMLDDAMAIGEELKTLRESLVQANLNLMDTKQSLTQLGHNLSDVRRGLEQTLSDSTCHADPVQTTCNDIRSSLGLVPDQLPSLEEHINNLTAVLR------TNLTALAHQGYNYLYTIPERVQ------NETVNIIADVKRALNSIGSNIETASQGFP-IRDRLSYFSSYLKKAEDYIHRYLRVLEEYDLYRWLGCLVA--------SLGLLCGTYGYDQSASPTGRGFISNTGGVFLM-----VGVGFSFF-------MTLVVLSFVLGANMEKLVCEPYQSKKLFQVLDTPYLLKEDWKYYLSGMIFDNSDIQITFEQVYSDCKENKSIYATLKLEHAY--------------NITDQVNITKYTGDIYSSFENMNISIKNVMKVDEEGRRNLRAFHSELDKVDYAAIMAETAKPPTQVNLLTFADNLDAKASNLSHAETLRRIHDVQVVLLQRLLSAVYQCMQELQQKTTGLGVRMQNILFFVNDTQNFVTNLITAVVHEERR-KYVTTILSYFEQYLQWVKHSVTE.......................................................................................................................................................................................................................................................................................................................................... 746
69 -9.800PF10234.7; CLUA1_MOUSE/14-283; Clusterin-associated protein-1  ali follow..  13  9...................................................................................................................................ISMENFRTPNFGLVSEVLLETEQDRVFFIKAIAQFMATKAHIKLNTKKLYQADGY--AVKELLKITSVLYNAMKTKGMEGSNVGEEDISKFKFDLGSKIADLKAARQEITAKGASLYDLLGKEVELRELRTEAIARPLEINETEKVMRIAIKDLLAQVQKTKDLLNNVASDEANLEAKIEKRKLELERNRKRLQTLQSVRPAFMDEYEKVEEDLQKQYDVYLEKFRNLAYLEQQLEDHHRMEQER........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 270
70 -9.730PF15960.3; Q4V3S3_DROME/9-228; Domain of unknown function (DUF4763 topsan)  ali follow..  10  2.................................................................................................................................................................RAPGIPK-DLVSSGIDPSDAEEETDLDAAYDELEEMKQRLITLRNKIIITNPDACQDLKIRDLW--------TPEGGELQELRDQKCQLICQLQEATQHLKDSQNELKELETWRCHLQLRIHQAKRQLSQFENFKLKVIHQFGLCIERWENQKTCKLDCTT-YRKEMAAHILHADNSRKSVVYQKCHKSYRRRIRVELMLVRVFLHNLFEAMVNDFRFFSRH.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 220
71 -9.710PF03904.11; YP2A_STAAU/1-230; Domain of unknown function (DUF334 topsan)  ali follow..  11  1......................................................................................................................................................................................................................................MRKGQLIMSMKDIKNNKENPNTQMNSKSTGTPSSSTQNSLNNEELSELKRQNKLIVKYLAEIQENQKIREKEQKEITSELKEATKDFRDKSLKIRNDFVDVLQEKLKHVDTEELKDILGRGIYKVREENDRMLQEVKRSHEHYQTRQKYLFTGIGAML............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 158
72 -9.660PF15175.4; D5K8A3_PIG/10-191; Spermatogenesis-associated protein 24  ali follow..  11  1................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GGSGSVCLAFDQLRDVIESQEELIHQLRNVMVLQDENFVSKEEFQAVEKKLVEEKAAHAKTKVLLAKEEEKLQFALGEVEVLSKQLEKEKLAFEKALSSVKSRALQESSKKDQLITKCNEIESHIIKQEDILNGKENEIKELQQVISQQKEIFRNHMSDFRIQKQQENYMAQVLDQKHKR............................................................................................................................................................................................................................................................................................................................... 180
73 -9.540PF15619.4; C3YX78_BRAFL/18-210; Ciliary protein causing Leber congenital amaurosis disease  ali follow..  17  8................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ARRVKIKDLTSQIFELQRELDDLRRENKLLKTLQHKQEKALTRFEDQESDLPQLLARHSAEVRNLKERLRHKQDSNHRSEQKIKDLRDDLEKKEHQVSKLQKIVRDKDELNRKLMRTEQMLLDKEKKVTELNKHLELVQGSSTRQLNAERARHKETQDKLSSLQEEYERLQNKLKEKEKEL.............................................................................................................................................................................................................................................................................................................................. 193
74 -9.460PF08580.8; V5HV84_BYSSN/491-1186; Yeast cortical protein KAR9  ali follow..  12  1.......................................................................................................................................SFS----SQLSQLTSINLPEPSSLEGRISSIPDAAAAIRALNGAAQQIQTWIGKASDVLSGLDAEDDVEWAAAGGREGLDDVDRAITKFEVNVYVTAIEDVQLR-TINGDVLKTIVVQMETILQNWSRIRTHLKGVKEQVELAMEWEELWGVVLGDVGLEVEDLGRVIFELEEK---------RHLSMFEDEEEAEGNNGMDISELETIIEETPPTNSTPNKRFSMPQTYSTPSQQPVPRSTGPDDSALLGLFARLQPLRASLDFLPMRLSMFQSRAERIPTACQDLEMKREKLENAYKKLESDAEVLRKELDEDRLVFRNAGRQARTMCESVERSIGKLQEALDTGAQHATLAKRIESFEAKKIHYGPAIERVLSIIEK................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 378
75 -9.450PF12795.5; Q7MYS5_PHOLL/31-261; Mechanosensitive ion channel porin domain  ali follow..  1....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ELKQIESSKNPQDAEVAQALQGALNWIADTKSANDRTQKYQTAIDDFPKITKELRQKLLTESDTPRPIPANQPIVEQQIIQVSSRLLEQGGQLQQEQDKGREISDSLVLLPQQQSEARRLLTEASSRLQSLGTPSTPLEAQFALAQAEVNAHKATVNELEIAQLSANNRQEISRMRVELFKKRYHRLDLELQQLRSQLNAQRQQKAELALEHTEMLAEQSD.................................................................................................................................................................................................................................................................................. 224

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Slabinski L, Jaroszewski L, Rychlewski L, Wilson IA, Lesley SA, Godzik A. XtalPred: a web server for prediction of protein crystallizability. Bioinformatics. 2007 Dec 15;23(24):3403-5. Epub 2007 Oct 5.