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PF02463
Query: PF02463.14; SMC_BACSU/2-1172; RecF/RecN/SMC N terminal domain, from PfamA26U

Results of FFAS03 search in PfamA26U
Master-slave alignment does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst FLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAIRWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTRRVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSIFEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEKKKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKIQALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETVLKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHSQVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVKEVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQNSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTVLITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDVTKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQVAEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQKQTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSFLTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMKRLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKRVKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMTKRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNLLSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIVITHRKGTMEEADVLYGVTMQESGVSKLast
1 -247.000PF02463.14; SMC_BACSU/2-1172; RecF/RecN/SMC N terminal domain  ali  100  1FLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAIRWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTRRVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSIFEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEKKKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKIQALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETVLKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHSQVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVKEVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQNSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTVLITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDVTKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQVAEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQKQTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSFLTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMKRLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKRVKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMTKRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNLLSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIVITHRKGTMEEADVLYGVTMQESGVSK 1171
2 -47.100PF13514.1; B5J9R5_9RHOB/33-1144; AAA domain  ali follow..  11  1...........................IYGPNEAGKTTTMEAAL-----------------RLFY-GFPLREAYAFKH--------SATFDIEGAARRFTRL--KRIGSLVDETGTALPEAALSAHL--AGLSEGDYR-LDDETIEEIANAQGDIGRLLFSAAAGVADLSGVLDGVRDEANSIRGRTTRIAELKHALADVEKEIREKDVTAGAWKGLKKALTQAQ------YEQAARKSRDVLNISKAQIAGQQRALPLMAE---STLEKSTATYSEYPDQLDFDPERLIELRTDHGTASQNIERLTMEITALKNELDEITLDKEQLELAVQ---DALHDLSVRNRSAQLDLQRRQVEKDVAEEAMSSAALDLGVSPKADLQDLVLSQADISKLETAKEELRDAIASVANESREVADLKKKLEAAGDAVETNTGDTDDSPSISDFDVDRLAPAHAAALQAIGAAKTKARKALSALTFGTVVFEDVPTGVSSMIQAQSWAAEHEKISQTIHNTIDKRDNHQEDLATRIAQGKVLTAGGAVVTDAETEVLLTAREDLWAEHQAALESQ----------------------------------------------------------TASAFYEAMQKHDKA-------------------------MDARVTHASELGQLRQIEQAEVEAQIRLEQADKRLEVLDKELTALDAAVGAATEDAQALFAAREEHQPILDRAEDLRAELSRLLTFEATDVASALTVARQVAEGERKQSENEARAQETLQQAKRNLRKREERHQAALSVEAEARNAWYTLILEMLGDRIAPENLQASLEPLR-ELREHAKTRASAAQRVASMKVDQERFAEEVAALAKAYAETFSALKTLSDRARSAHEAVEKLTGDIKEAEARKSKNSEKLREIKQAIEAIAQQVIEERAALVKLQRTVVSELGVNDIKAAREEMAALSLTDLEAAFENSKSDLERAEE-QVTGDADIATLVEQKATLELQLEDSALEHLELSLGHYLASNSIRRYRDSHRSGMMTATERCFASLTQGAYPSLITQVDKD----AEVLLAVDCTGASKRAAEMSKGTRFQLYLALRAAAHEQTRLPF-FCDDIFETFDEDRTSAACRVMETIGSRGQAIYLTHHRHVVDIAMKVCD.......... 1104
3 -41.400PF13476.1; C4P4D4_ARATH/25-232; AAA domain  ali follow..  21  1...RIRLENFMCH-SNLEIEFGDWVNFITGQNGSGKSAILTALCVAFGCRARGTQRAATLKDFIKTGCSY----ALVYVELKNQGEDAFKPEIYGDTLIIERRISDSTSLTVLKDHSSRKEELRELVEHYNIDVENPVIMSQDKSREFLHSGDKDKFKFFYKATLLQQVDDILQSIGTKLNSANALLDEMEKTIKPIEKEINELLEKIK.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 208
4 -35.400PF12128.3; Q8EAA0_SHEON/1-1188; Protein of unknown function (DUF3584 topsan)  ali follow..  10  16......................NGHTNICGTNASGKTTLQRLVPVFYGEYPSRVVPSTRDS-IIY---EYQKADGLLYQAVLASAGDGK-----------RFIAKGFELSDYIKSQN---AELGRDLKRQGINTREYRAIIQNDRTLLSTGSNRSELRAYARQFALCDGEHSLEKLAKAVHSKEGKMETVKSMIAAIPQRVEAWIRESQLIQGFEVIRPEFEKLEQEF---QLLSAEMRLSSLSRGYRNDESLEADRLEIQQTLSKELDEWKEVRDELNLDLSAAKGDVAKCEYELDAIEDQHGAFLDAAKADLDMLPNWRADMENLSERHKLQTEKHQDIEAAYNARRSKIEQLNRELEGLHSEQDKQREARDKQREVARGDLDALEAQWRSQMDAGKASFSEQEYQFKLNAAELKLRVDGVTYTEEEKLNLAIFDERIHRADEEQESCNAKVERLTSDERKLRAKRDQANEALRIASLRVNERQTALDELHHMLFPQSH-----TLLEFLRKEAQGWEQSLGKVIAPELLHRTDLHPSVTGESDTVFGVNLDLKAIDVPEYAASE-----------------------------------------------------------QELRIRLSKAEE------------------------ALQSAQELQAEAESQLVAINGELDKLSRELTFARTAYKNSRDDLRRLFDEKRSEQDKINKLAERKAFAQQRLTQLDGELKQLKHQHQLWLEEQKEQALEANQLGQIKATIDARRESAKAEQKACETWYKNELKSRGVDEDNILKLKQQIRELETKISRAEQRRSEVLRFDDWYQHTWPKLQTQLSDVKRAASEIDQQLKAKTQEVKTRRQQLETERKASDAAQIEASENLTKLRAVMRKLAELEEAQGSLGERLRQGEDLLLKRDYLMGSVKQYVEHFDSVIASKSGSGLAETWERAREESSINDKGIRLLDYRKLVPQLEQLNVIVPQSIMALREQGRIFGVDLTAFYDVLADIDRRIASQSARITREVGEE--RIRSKISELALDIIGRAALTGGISK--RLKEGNSDLIIR---RQLNESS--SHGMAYLILCKFLLAFTRLGRADVWPIDEL-GTLHHTNVKKIFDAC----GNNNISVLG........................ 1167
5 -31.900PF15921; G3SYM2.1/1-1109; Coiled-coil domain-containing protein 158  ali follow..  13  145.......................................................................................................................................................................QLQNTVHELEAAKCLKDDMLKDSCTQIEQLRKMMLSHEGVLQEIRS-VDFEEASGKKVYDHESMSALHVRNLGSAIGKILRELDTEISYLKGRIFPLEEQLEALKSESQNKIELLLQQHQD--RIEQLMNEHEVEVTGLTEKASSARSQANSIQSQLEIIQEQAR---NQNSMYMRQLSDLESTVSQLRSELREAKRTYEDKIEELEKQLVLANSELTEARTERDQISQESGNLDDQLQKLLGDLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQEKERAIEAT----------AEITKLRSRVDLKLQE------------------------------------------------------------------------------------------------HLKNEGDHLRNMQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKEAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTCRSELNSLTEDYEVLKRNFREMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNASKEKHFLKEEKNKLSQELNTVATEKNKMAGELDVLRSQERRLKEKVANMEVALDKFAECQDIIQRQEQESVRLKLQHTLDVKELQGPGYTSNSSVKPRLLQPSSAARSHSNVPSSQSTGSFLSHHSVKSNTLKEDPTRDLKQLLQE............................................................................................................................................. 905
6 -31.800PF06470.8; Q0UYB6_PHANO/522-635; SMC proteins Flexible Hinge Domain  ali follow..  25  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LPGVHGTIADLLEVPEQYRTVVENAAEGAMFNVVVDDDSVSTKLIDRLIKDKAGRLTFIPLNRIHAPDLN-------LPTRSDMQPLLPKLRYDEQFEDAIRHVFAKIVICPTLDACKSNA....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 114
7 -31.400PF01576.14; O44934_LOLPE/1067-1925; Myosin tail  ali follow..  11  128.......................................................................................................................................................................KNQEATNELGDQIDQLQKVKSRLEKEKTQLRAEMDDVQSQVEHAGK-GCSEKMSKQME------QLSELNAKIDDQARSVSELTSQKSRLQTEAADLTRQLEEAEHNVGQLTKLKSSLGASLEDAKRSLEDEGRLRAKLQAEVRNLNSDIDGIRESLEEEAESKSDLQRALSRANAEVQQWRSKFEARADELEDAKRKLQAKLSEAEQTADTLHSKCAGLEKAKSRLQGELEDLAIDVERSSAHANNLEKKQRNFDKVVSEWQHKCNDLQAELENAQKEARSYSAELFRVRAQCEEVGDTVASLRRENKNLADEIHDLTDQLGEGGRNTHELEKARKHLALEKEEQAALEEAEGALEQEEAKVMRATLEIS-----QIRQEIDRRLQEKEEEFDNTRRN------------------------------------------------------------------------------------------------------------QRAIESMQASLEAEAKGKAEALRIKKKLEGDINELEIALDATNRGKAELEKNVKKYQGQIRELQSQVEEEQAQRDEAKEHYQMAERRCAAINGELEELRTILEQAERARKAAENELADASDRVNELQAQVSTVGSQKRKLEGDVTAMQSDLDELNNELKDADERAKHAMADATRLADELRQEQDHGLSVEKMRKSLESQVKELQVRLDESEAALKGGKKMIQKLESRVRELEAELDSEQRRHAETQKSMRKVDRRVKELSFQQEEDRKNYER---------------QELVDKLQNKIKTYKRQVEEA--------EIAAINLAKFRKVQQELEDAEERADQSEGALQKLRAKNRS............................................................................................................................................. 859
8 -31.400PF10174.4; Q7Q0K7_ANOGA/59-838; RIM-binding protein of the cytomatrix active zone  ali follow..  11  2.............................................................................................................................................KAKLENAQGEQESLKQEMERGQAGIQRIVSERDKAYAELEKIREELERTQATLGKSQLTQEKLQNSLDKAQEIDHLQEKLDKSGGETLQLEKEKINYEFENIQSQLDKSLGQASRIQKEKEAAQMDLDRYRDKADKLQSSLARLQKERDVLSDELEKLKEKSESTQSTALKYQRERDAIQTELEVVKERWEKAHQVHQKLQMERDDATTEIDILKEKLDKALYASQKLIDEKDTEFEKMLEKYDRAQNEIYRLQSRVDTAEADRNRLEVEAERSALAAAKAREDLRKIQEETTRLQEACDRAAMQLGRSKELEDKAKEDVDMIRERLDKCQTDLRRAQSEKDNQQAEIERLTYELDRSHNLYTKQTASLDSAQE---------EIARYGLEIEKMRERYEKTAAELRRLQENESFSREARRMKDE----------------------------------------------------------------------------------------------------------RLREKYDKVIVELENFRGKSQYEQETFDKMKEKFETRENEFQTMELKLHETSLQLDLARAEVTKLISNQDKQRADAERAHIEYEKIRDKHEKLIKEVERLRQNPQSAISPGAATSTVSLADKNELDRLRDRLEKALQSRDATEMEAGRLAKELEKAQLHLTKQQEVYEATRIEFERMSAELTRVLERLEKSEAEKETLRQSTK-IYEKHHQQHASNHHIEQSLMKLEADNKQLMAERDQLVMQLEKSQDMLMSFQQELNAAEVELQRQCEENRR------SSPQQPGSAPAAPQQGQAAAQEIQNYKKEITKLKQMLQETGARGDNELEQWRKVVEQEKNRADQAEKAAIELQKRMQ.............................................................................................................................................. 779
9 -28.700PF05483.7; SYCP1_RAT/28-813; Synaptonemal complex protein 1 (SCP-1)  ali follow..  11  4.....................................................................................................................................................DSNYFKTVNKCTEGDFGVPLTMSSLSKNRENIDTDPAFQKLSILPMLEQVANSGSCHYQEGVNDSDFENSEPMSRLYSKLYKEAEKIKKWKVSIESELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHWCNLLKETCARSAEKTSKYEYEREETRQVYVDLNNNIEKMILAFEELRVQAEEMHFKLKEDHEKIQHLEEEYQKEVNNKENQVSLLLIQSTEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELNEKKDHLTSELEDIKMSMQRSMSTQKTLEEDLQIATKTIYQLTEEKEAQMEELNKAKTTHSVVTELKATTCTLEELLRTEQQRLENNE---------------------------------DQLKLITMELQKKSSE--------------------------------------------------------------LEEMTKFKNNKEVELE------------------ELKTILAEDQKLLDEKKQVEKLAEELQGKEQELTFLLQTREKEIHDLEVQVTVTKTSEEHYLKQVEEMKTELEKEKLKNIELTANSDMLLLENKKLVQEASDMVLELKKHQEDIINCKKQEERMLKQIETLEEKEMNLRDELESVRKEFDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKSKNIEELHQENKALKKKSSAENKQLNAYEIKVNKLELELASTKQKFEEMINNYQKEIEIKKISEEKLLGEVEKAKATVDEAVKLQKEIDLRCQHKIAEMVALMEKDKIVEERDSELGLYKNREQEQSSAKVALETELSNIRNELVSLKKQLEVEKEEKEKLKMEQENTAILTDKK............................................................................................................................................ 786
10 -24.400PF05911.6; Q10P54_ORYSJ/79-939; Plant protein of unknown function (DUF869 topsan)  ali follow..  12  6.........................................................................................................................................................KQHAKVAEEAV------SGWEKAEAEASALKLQLETVTLAKLAAEERAAHLDGALKECKQVRTVKEEGEQKLHDVVFAKTKQWEKIKAEFEAKLLEFEQELIRAGAENDALSRSLEERGDLLMKIDEEKARAEAEIEVLKNTIQSGEREINSLKYEIHVVSKELEIRNEEKNMSVRSADVATKQHMEDVKKISKLEAECQRLRGLVRKKLPGPAALRDYGESRLRRSPAKNSSFHRPMSPMSPVPDYAFENLQHMQKENEFLTARLLSMEDETKMLKEALAKRNSELQTSRNMYAKTAGKLRGLEVQMLTGSQRKSTSNPNMDIHFDGASCTESWANALVSELSHIKKEKGAKSSVTEGSNRLE----LMDDFLEMEKLACLSSEANGHVSTVEKMKIDDTEASLSGITERDGVKDSQSVLALPGTPSNKLQLSDSSPLLKLQSRISSLLDSESPQNNAGNILDSI-----ILKDIEDEADSSNDSKTHHGDMV---------------VADNGSLMKHSSSGSKHAMDQELVNAILKIQDFVKSLDQEVSKFQGQSSDCDGLCDKIQQFSALVEKALSNENVLNDIVMTLSLILSGTSEIKFMMLKENTKEADNNNLDYVDKVTLLENKVQLEPLKDSISGPCLPRSSSDPEIEGPTDSSSEEFEQLKSEKLNLEAELSKCNEVIEETKFRFKELEKSLEELTSKLVASEKSNSLAETQLKCMAESYKSLESRKAELENEIKVLQSKIEVLTAELDDERQNHQEDITRYRDLEEKIERYENERNSMCVDEDADTKAKQEK---------EIAAAAEKLAECQETILIL--------------GRQLQSMRPPAESMGSS.............................................................................................................................................................. 861
11 -23.700PF05557.8; Q9W6G9_XENLA/2-716; Mitotic checkpoint protein  ali follow..  1......................................................................................................................................................................................................................................................................DDSEDNTTVISTLRSFNKFLSQPLEGTAPSLGTSTSTGASLQMQFQQRFLLEDQAAQIRSK-----SNLIQVEREKMQMELSHKRARIELEKAASTNAKNYEREADRNQGLHTRIKALEEKENEFQNKLQEQNEMIKSYKKTIEAQSKKLLEKEDKLSESNENISVLKGKASELQWKIMNQEMQIKTQETEKQELTEQLEIHRKKLQESNEKMQALHELQAQNADNEQKIKSLEQKLSAQEQDAAIVKSMKSDLTKLPKLERELQQLRDE-----------------NAYHREMKENNALLKEE-----------------------------------------------------------VEGLRRAAERFNKMKEDLV------------------GSEIEKEQLVKKLKLWENLEQSTGLNIRTPDDFSRQIMAVQQRELKLKEENMTIQISARMLETSRQQLQEELLKVQSGFLEEKKRREHQEALVRRLQKRVLLLTKERDGMRAILDSYDSELTPTEHS-PQLSRRLKEAEDILQKVQDHNAEMETQLSEALEDAGIQKQKSELLTAELKVLKSQMGSSDQNISFTNEAMSALRLKIEELEAERGRLEEENKILEMRLESLNLQGCYDPSRTKVIHLSLNPASKAKQQRTDTVRHLQEECDKLREIVRILEGGAQIP----------DKLEATGSPQSSQELAELKKQVESA-----------LKNQRLREVFQTKIHEFRTACYMLTGYRIDITTENQYRLTSMYGE..................................................................................................................................... 656
12 -22.300PF15070; Q5DTL1.1/404-1022; Putative golgin subfamily A member 2-like protein 5  ali follow..  11  1...............................................................................................................................................QLMESLKQLQVERDQYAENL------KGESAMWQQRVQQMAEQVHTLKEEKEHRERQVQELETSLAALRS--QMEEPPPPEPPAGPSEAEEQLQGEVEQLHKELERLTGQLRAQVQDNESLSHLNREQEGRLLELEREAQRWSEQAEERKQILESMQSD----RTTISRALSQNRELKEQLAELQNGFVRLTNENMEITSALQSEQHVKKELARKLGELQERL----GELKETVELKSQEAQGLQEQRDQCLSHLQQYAAAYQQHLAAYEQLTSEKEAIHKQLLLQTQLMDQLQHEEVQGKMAAELARQELQEAQERLKATSQENQQLQAQLSLLVLPGEGDVDQEEEDEEVPQSSL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------AIPEDLDSREAMVAFFNAAIARAEEEQARLRVQLKEQKARCRSLSHLAAPVQSKLEKEAVVPRNVDD--SASEESNQALHVAMEKLQSRFLEVMQEKVELKERVEELEHCCIQLSGETDTIGEYIALYQNQRAVLKARHLEKEEYISRLAQDKEEMKVKLLELQELVLRLVNERNEWQGKFLAVSQNPGDVLTPVPTGSQEFGAADQQDDLREVSL---ADDIEPAQGEAGVPAPHENPTAQQIMQLLREIQNPRERPGLGSNPCIPFFYRADE................................................................................................................................................................................................................................. 610
13 -22.200PF13555.1; Q0A6A1_ALHEH/19-80; P-loop containing region of AAA domain  ali follow..  27  1.LQRLEVFNWGTFHDRVSLQPGGDNSLLTGDIGSGKSTLVDAITTLLVPAQRITYNKAAGAE..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 62
14 -21.900PF07111.7; CCHCR_PANPA/27-782; Alpha helical coiled-coil rod protein (HCR)  ali follow..  10  65.................................................................................................................................................AEVIARQLQELRRLEEE---VRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEV-KNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKHSQTWELERQKLLETMQHLQEDRDSLQATVELLQVRVQSLTHILALQEEELRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEEAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQL-----------------------------------------------------------------------------------------------------------------------------------------------ESCPLPPPVADVSLELQQLREERNRLDAELQLSARLIQEVGRAREQGEAERQQLSKVAQQLERELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQE-TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLTVLPSLLDKKKSVVSSPRPPECSASAPIAAAVPTRESIKGSLSVLLDDLQGLSEAISKEEAVCQGDNLDRCSSSNPQMSS................................................................................................................................................................................................................................ 756
15 -21.400PF15964; Q5PQY1.1/1-716; Centrosomal colon cancer autoantigen protein family  ali follow..  10  1.....................................................................................................................................................................MAKSPGNSTLEDSLGQYQRSLRERANRSIHQLKCALREVDATIEEAWHELQHSHAVNQLKALLRQQTSTENETSPRRRKLSPSRPSDCEDGSLPTMHNLVPIINDQSQYIHHLEAEVKFCKDELSSMKNRVQVVVLENERLQQELKSQRQEETLREQTLLDMSGNVQNSWMKTREDSRVIETTKRDADKWRLELERLKLTYEAKTDLLESQLKLLRKDLVEYQKTCEDLKERLKHKESLVTASASCLKCAQHEAVLSQTHNNVHIQTIETLTKERDDLMSVLVSVRSSLAEAQERETSAYKQVKHAVQMTEEANFEKTKALIQCEQLRSELERQT------------------------------------------DRLEKELASQQEKRALEKEMIKKE------------------------------------------------------------------------------------------------------------TREREEAEAKMLILSQNIAKLEAEIEKITREKTSAVSQLEEVQNQLASQEMDVTKVCGEMRQLNKTKMEKDEAEKEHKEYKAKSQKDLEMKDQEIEKLRLELSESTQQVEQEQQKAARARQECLQVTELLGESERQLHLTRLEKDSIQQSFSNAKAQALQALQREQELTQKIQQMETQHDKTDSEQYLLLTSQNTFLTKLEECCILAKKLEKVSLKSRSEIVQLSQEKRYLCDKLEKLQKRNDELEDQCVQHGRVHETMKERLRQLDKHGQATAQQLVQLLNKQNQLLLERQNLSEEVDQLRAQLPSMPQSD......................................................................................................................................................................................... 715
16 -20.700PF05622.7; HOOK3_HUMAN/5-718; HOOK protein  ali follow..  11  20..................................................................................................................................................................................NVDAPCQTVEDLTNVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAE--------NQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEID-VLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVK------------------------------------------------------------------------------------------------------------------------------------------------------------------LLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAEIVTPEIREKLIRLQHENKMLKLNQEGDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQEDRLFHSLEKEYEKTKSQREMEEKYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSRRSYPGHVQPA............................................................................................................................................. 711
17 -20.600PF09730.4; Q3TBD4_MOUSE/9-723; Microtubule-associated protein Bicaudal-D  ali follow..  11  2.............................................................................................................................................................................QAHTNHKKVAADGESREESLIQESASKEQYYVRKVL------ELQTELKQLR------VLTNTQSENERLTSVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNNLRKELSHYMSINDSLQVSLDGLKFSDDTVTAEPNNDAEALVNGFEHSGLVKSSLDNKTSTPRKDGLAPPSPSLVSDLLSELHISEIQKLKQQLVQMEREKVGLLATLQDTQKQLEQARGTLSEQHEKVNRLTENLSALRRLQAGKERQTSLDNEKDRDS-------------------------------------------------------------------------------------------------------------------------------------------------------HEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEA---EGQALTEKISLLEKASHQDRELLAHLEKELKKVSDVAGETQGSLNVAQDELVTFSEELANLYHHVCMCNNELDYYREGQGKAGRTSPEGRGRRSPVLLPKGLLATEVGRADGGTGDSPSPSSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTNEQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTE------TMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQ-KLALTQRLELLE................................................................................................................................... 714
18 -19.900PF04310.7; MUKB_ECOLI/1-227; MukB N-terminal  ali follow..  15  7.FRSLTLINWNGFFART-FDLDELVTTLSGGNGAGKSTTMAAFVTALIPDLTLLHFRNTTEAGATSGSRDKLKAGVCYSMLDTINSRH------QRVVVGVRLQQVAGRDRKVDIKPFAIQGLPMSVQPTQL------VTETLNERQARVLPLNELKDKLEAMEGVFKQFNSITDYHSLMFDLGIIARRLRS--ASDRSKFYRLIEASLYGGISSAITRSLRD.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 219
19 -18.400PF00261.15; Q805C4_TAKRU/12-248; Tropomyosin  ali follow..  10  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RKIQTLQQQADDAEDRAQVLQRQLDSERELREKAEGEVAALNRRIQLVEEELDRAQERLAVALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAELSECKASDLEEELKNVTNNLKSLEAQAEKYSEKEDKYEEEIKILTDKLKEAETRAEFAERTVTKLEKSIDDLEEKLSSAKEENLGMHQVLDQTLLELNSL................................................................................................................................................................................................................................................................... 237
20 -18.300PF07888.6; Q7ZTT2_DANRE/1-545; Calcium binding and coiled-coil domain (CALCOCO1) like  ali follow..  11  46..........................................................................................................................................................................................................................................GWLTVKDYYTFAWALAPEGYQKGADANCSVAFHPSYLPIPGVEEYQFVYVDGRGDVCAISSQFTFAAPRPLDELVTLEKSGEGEEDGDDLLLVVPKALILQNLLEGCQRELHELHKKFEAVNGDVENERQRWKTDRDEFEILRSDMRSQIEQLKTNLRHSTEKTEELERKHKEAQSSSESMSAEFNALLAERAENQQRIKELEQDSATLTQQKQDIEAELERMKERVKKMTIQRRDEETERIDLQLENEQMHADLRTLQERLEA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SERSTGALRRDLSELGSLQSHSHAELHQVRLQSAQMSLQLSQANLALREGQ---STWAQERETLRQSAELDKDRVQKLSRELQKKEEWLQEERSEREKLEVELGIEKDCNRELRASLRALQKEQEQHQLEKQELLDHIHVLELRLDTETDAKWAEAAATPICQFAKSYLHRAAYIDSLPSIDEKPLLESSSELSLSALDSEQHNESTEKNPKDNEDDVMQEDLEVQPFSSGIADQMLS.................................................................................................................................................................................................................................................................... 544
21 -18.300PF05701.6; Q9FWW5_ARATH/24-519; Plant protein of unknown function (DUF827 topsan)  ali follow..  2..............................................................................................................................................................................................................................................................APFQSVKAAVSLFGEVAVSKQRSTPRRSRLSSESVCDKETQLMLVHKEFMKIKQKLDNAESTRSRALDDLSKAKKTMEDLSNKLETVNKSKQSAIDTKETVQQREEQLEHDKCHGSPPHHHELDVAREQYISTTVELDAAKQQLNKIRQSFDSAMDFKATALNQAAEAQRALQVNSAKVNELSKEISDMKDAIHQLKLAAAQNLQEHANIVKEKDDLRECYRTAVEEAEKKLLVLRKEYEPEL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRTLEAKLLETTSEIEVLREEMKKAHESEMNTVKIITNELNEATMRLQEAADDECSLRSLVNSLRMELEDLRREREELQQKEERLEIEETKKLEALKQESLKLEQMKTEAIEARNEAANMNRKIESLKKETEAAMIAAEEAEKRLELVIREVEEAKSAEEKVREEMKMISQKQESKKQDEESSGSKIKITIQEFESLKRGAGE---TEAAIEKKLATIAAELEEINKRRAEADNKLEANLKAIEEMKQATELAQ.................................................................................................................................................................................................................................................... 496
22 -18.100PF13166.1; Q63PW4_BURPS/9-780; AAA domain  ali follow..  12  119..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EVEIDKLEDELGSVENKTGLRHSYQEK-KKAHADKKKAAQDAQDELDKKIFDKANKNPTGIKHNSLYKDANYDVRKLKLDIKTVQDKKIAPLDDADRSSKVKLLSEVALPDIEKSLPALAKSTVELITKKIKPSAPIQELPLPADLWKRLGDHFNQESQDLEKDLDSVLTKISNEKTRIKNVVTVDRKYSANQATFDNLKADLDDAINNHEKSLQSLEDELNARKKDIFT-ERSTIDVQDNTVSISQKVSLVNELIERNNKTTTSLEEDQKIARNELRLSEISQFTIDIDLAGEEKKIKALEDQITKA--------DELDAVEAEGKKRVDRVKELRTQLRDEKRGAEQVNQYLGHFL---------------------GHGGLSLSAVEEANTATYRFQIL---RGDQAAYNLSEGECSLVAFCYFLAKLEDIETLIIYIDDPISSLDSNHIFFVFSLIENYYRYEQLFISTHN...................... 622
23 -17.100PF04849.8; Q4SVU4_TETNG/101-401; HAP1 N-terminal conserved region  ali follow..  12  1.................................................................................................................................................................................EYICLPSHGGKAKEVEEEEMDEEQQIGRSSMTTKLLWLKFLRV-----------LCADRVGQMTKTYSDIDAVTRLLEEKERDLELAARIGQSLLKKNKALSERNDLLEEQVEHIREEVSQLRHDLSMKDELLQFYTNAAEESEGESFTSTPVRPADSNVSTPTFFPLDSLQKKLKDLEEENKSLRSEASHLETETISYEEKEQQLVHDCVKELRNSNLQITSLSEELARKSDDASRQQEEITHLLSQIVDLQKKVKLHALENEELTQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNK........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 300
24 -16.700PF09738.4; LRRF2_BOVIN/31-326; Double stranded RNA binding protein (DUF2051 topsan)  ali follow..  10  6..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRVSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEKHGLVIIPDGTPNGDVHQEPAVGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSGRDGTAGDLAELQNGSDLQLIEMQRDANRQ-----------------ISEYKFKLSKAEQDITTL............................................................................................................................................................................................. 296
25 -16.200PF08580.5; Q6FY01_CANGA/41-592; Yeast cortical protein KAR9  ali follow..  10  7..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................CDVLEWITTQMNRILEIFPQIIDSTGIEVSSLLEYLDWLQERKELLFELVNDINSIGPFLSDILEGIELNTDPNKSLDEHEMHLIDLIERCSTLRDDLDPWLNKLRKLLDATLEFKEISNDHMDGLDKVVSENIQDIQEERFTSPVRHAPSFTLEQIVDLLKQNSDSNAISVPTFNKQEKLISERFLELRRSVPAIEKSLTDILPNRIDNRRDMTNIDSLAEFLRDKYKVLMKKYEFMSSEISELNAELIDKRILFVNLNHEINFILDDY-EKLKKKLNSVEEIGINVQIREKMSHQMTQKSLTIERTFKVIFKAQEF-AGIASKTNEMKNRWEKVRVDDKLLRSVSVDSGPEISS............................................................................................................................................. 373
26 -15.900PF06160.7; EZRA_BACP2/3-562; Septation ring formation regulator, EzrA  ali follow..  13  27.....................................................................................................................................................................IDRLEAWKIEILNRSIVEEISKIKHLKMTGETEQFFERWRAEWDDIVT-PKVEELLYDAEEYSDKYRFSKAKQVLTHIEDLLSAADSNIEDILKEIADLVTSEEQNRKDIEKVKEQYQTVRKNLLAYSHLYGTLYDKMEQDLDEAWEGIKQYEEETEN-----GNYMKARKILLEQDRRLDQLQLYINDVPKLIADCKQTVPGQLTKLKDGYQEMSEKGYKLEH--IQITKELETLNKQLARAEKLLID-ELNLEEASSILQMIDDAIETLYDQLEAEVEAGQEIKSRMPELTEAFEKLEQDHTQTKAETALVKESYKLTAGELDQQKAFEKRLE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIEKLMKQIREKLDRDHVAYSLLMDEINQLETFIEDAKALHDTFKGHLQSLRKEELQARETLAELKTMLTDTVRQLHK-----SNIPGVPAEMKERAEKAQEMIHQVHEQLENLPLNMPAVNQQLKEASDTVRNVVDETEEMLSKVDQIERIIQYGNRFRSQNHILSEQLKEAERRFYAY--DYNGSFDIAAAAVEKASPGAVQKLLAQQE................................................................................................................................................................................................................................................................................................ 559
27 -15.500PF15934; B4NYC9.1/468-698; Yuri gagarin  ali follow..  13  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LREIADLICKLGSMEFSYNEIYDESSRENPFCTTIAELFELRSQQEQKHTALNEHLACQIQGLEDNLKDRDNQINQLQSMIKSYSDL-----TENSRLKGEIHDLKLKNCDLSRQLRELSSLMRNQEDQRVELCSKYENLMTNFEDQCQELKGAKRKVQSLQSRLDQVEKLQDELRTERKMLREEVIALKEKEAVSAGRERALQEQQKIGHLELEKMRNHIRNMQDHLQLDDIR....................................................................................................................................................................................................................................................................... 230
28 -15.200PF09728.4; Q5RIN4_DANRE/94-406; Myosin-like coiled-coil protein  ali follow..  10  3.....................................................................................................................................................................LGKEAASLLQSLNKLGSPEEKVEMVLKKYSELVDEHRTEKKQLEQFQQ------------------RQGLLVKQRDQLQFEHSRAILARSKLETLCRELQRHNRTLKEESLQRLREDEMKRKEITTFQSTLVDIQSQIEQHSNRNNKLCKENSELAGKLKTIIEQYERREESLEKIFKHRDL---QQKLSDAKLEEANMLLTQAEEKHKREKEYLLKEAIDKTKKYCTLREQELQMKKQLVLYSQKFDDFQNTLAKSNEIYVTFKQEMDKMTKKMKKLEKESTTWKTRFESCNKALVEMIDERSEKGKEFELFTLKIDRLETLCRALQD..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 311
29 -15.000PF09787.4; A7USX6_ANOGA/12-516; Golgin subfamily A member 5  ali follow..  13  90.........................................................................................................................................................................ENASYSKPEPSYSIEQELAAIKIVLAEIKAERDELKSELDSTLSQQLSNGETES--------KLLDLEVLCQNLSEEKMALAGKLLSLEEANGKYVKSISELESTIAKHIQSEQELNSKLDMARLETENALTELQQYRVRAHATLQLKEKTIEQLKEQMSGSGRTDSAEQILQIELEQTRQEKANLAEELTSLNDRMKQREAQWMNAEEKLRVTVHALEQNVQRLQQQILLDADKFSVLEDDFKLKQRELASVREDLTSFTLRLHEKESENSKLRNKIHTPVSPLNDQEDRLASLTQSLVQKQTALETVTVERNALRIQLEKLENQYRNTA............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 427
30 -14.800PF15742; F1SF94.1/171-554; Domain of unknown function (DUF4686 topsan)  ali follow..  4................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SGDRTKSQPQEELQQLRQDLHRLQVLCSSAEKELRYERGKNLDLKQHNSLLQGESLKIKTELKQAQQKLLDSAKMCSSLTAEWKHCQQKIKELELEVLTQAQSGKSLSSLEEALAREKSNVAAAEEKISDLQQKLEHGKKQLEERIKEAMENEAKIKQNYQEEQQKRKLLHQNMNELQNQVKTLQDKERQLKMTNVQQQLRIQQQEAQLKELKNERRLCDESNQELSEKLSGLQQEKEALGRECGRLLKQLDVHVRNYNEKHQHHKAKLRRVRDHNTNESIETLLEVECSDIVKCEPPKNEEEKEFQKQVIAQNDTLSLEKRKLREQLVRQEGIIDKNRWMLSSVQKRVLFLDQENKH............................................................................................................................................. 376
31 -14.600PF10168.4; Q707M9_XENLA/4-726; Nuclear pore component  ali follow..  376...................................................................................................................................................LYRDPICPSRYHCTHVAGVHSVG---NRLEKFLSSGEEDKDSLQELAAEQKCLVEHILCTMPLRCRMICITCDFECIARPL-LTTIRPPSPPLLCSQIDKSSTEILPHVLADVKGPFEIHIRGILRRNSANPLLLNSSSKDSSPPPEECLQLRATQVFREEYLLKQDLAKEEIQRRVKLLIAQKEKQLEDVRYCREERKSLTETAEHLAEKFEEAKERQEDLINRLKRILRSFHTQLPVLSESERDMKKELQATTEQLQHLGNCINQVKRKMSYQEKQMEKGKSPR---KSSLTLSDYQKKNIKTVLKEHGEHIQEMVKQINNIRNHVN....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 722
32 -14.600PF10481.4; CENPF_HUMAN/1-288; Cenp-F N-terminal domain  ali follow..  11  19.......................................................................................................................................................................................................................................KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSAGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQ.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 288
33 -14.600PF14915; E2RN06.1/24-306; CCDC144C protein coiled-coil region  ali follow..  13  5..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QDELAMLRLEIDTIRNQKQEKRYCEDTETEKEKNDSLQNAIKLNENTMLNSKLQDEKLNRERLEAKLQSYRARLATAIQDRDQSQASKRDLELAFQRAKDEWDKMNFEMSNLKDNNEVLSQQLSEVESKFNALEIELQHTRDALREKTLALEHLQRNPKQTQGQKKEIEQKSQNEHGKVNKYIGKHESLEEKLSQLQSENMLLREQLDDAYSRVECKEKTIIDLKDQVQVIVRMVRAGEKRNLLLREKNKELINKCKQIMERAFRYEDEKEE................................................................................................................................................................................................................................. 281
34 -14.600PF03999.7; PRC1_HUMAN/37-615; Microtubule associated protein (MAP65/ASE1 family)  ali follow..  12  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LQRTEVV--KKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGET----TILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEALDHTPDTSFE-RDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKRKALQLEVDRLEEKMQNMKKVIEAIRVELVQYWDQCSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKEL-FEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKE--EKQRAKLQKMLPKLEEELKARIELW......................................................................................................................... 377
35 -14.500PF06008.9; P70570_RAT/237-496; Laminin Domain I  ali follow..  10  2...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LQGLSVNTGSLEQIRHVEMQAKDLRNQLLGFRSAISSHGSQMDGLEKELSHLYQEFETLQEKAQVNSRKAQTLYNNIDTTIQNAKELDMKIKNILTNVHILLKQIARPGGEGMDLPVGDWSRESAEAQRMLRELRGRDFKKHLQEAEAQKMEAQLLLNRIRTWLESHQVENNGLLKNIRDSLNDYEAKLQDLRSVLQEAAAQGKQATGLNHENEGVLGAIQRQMKEMDSLKKYLTEHLATADASLLQTNSLLQRMD.................................................................................................................................................................................................................................................... 257
36 -14.200PF09789.4; Q16UI1_AEDAE/24-343; Uncharacterized coiled-coil protein (DUF2353 topsan)  ali follow..  11  1..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HRKLQSKVEALKIMRNELEKYRSERDQFKLMAETLQMRYSAMKSSLNSPEFQAAGFG-HSSAVSLLVNQTRERNISLSTEVEALRQRVHELEGDIDVLRTKNFDLQAAFNKMKSTEETKLRDRKVWDEEKSKLIAQMETLKKKNAQLQYDVRSLLDEKEDVVMERDAYKCKAHRLNHELSVMLKGDQSQQK-----IVDVDGLILENKYQQEKITNLENELELSRQSATKYKNMLDTKRKKGIIKLGTNNNQRVMSHSQVKDLLE--------------------------RGTVEELPLKAATISELKSLCLALLDNVNDKSLALSHQKKTNKLLAAKITELEQRILAL................................................................................................................................................... 320
37 -14.000PF06818.10; Q4RYH9_TETNG/478-682; Fez1  ali follow..  10  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KWEVCQKSGEISLLKQQLKEVQGELAQRVGEIVSLRGQLRETRGELTNTQVLLQEAHGTTRTRTLELEVCENELQRRKSEAELLREKAGRLEAELAHLKDALASQGPGNRQCQVFPEDQEQLLA--RAQEPSGGEVLQNMSVKMDRMRAELSYEHQRAEQQMSSFEEERRIWQEEKDKVIRYQKQLQQNYVQMYRRNRELEQLLQE................................................................................................................................................................................................................................................................................................... 205
38 -14.000PF12795.2; Q3KJ67_PSEPF/35-273; Mechanosensitive ion channel porin domain  ali follow..  11  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SLDKLTDSKLPEADKKALQTVLQNTLNQLNNRRDYEQKLIDLKQQLATAPKQTIENSRELTRLKASAVVPVAQRFP-KENIQQLEQMLTERSTQQSDLQKALADANSLIITAQTRPERAQAEISSSQTRIQQINNILKTGKDAGKTVAEQRDLLNAELAALNALIPLRRQELAGNNQLQDLGNSQHDLLSEKSDRLDREIQELQTLINQKRLTLSQETVTQQSIEAQKSGSSALLAT.................................................................................................................................................................................................................................................................... 238
39 -14.000PF15905; E9Q837.1/14-339; Hyaluronan mediated motility receptor N-terminal  ali follow..  12  13..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VKTSEATKGPVSFQKSQRFKNQRESQQNLNIDKDTTLLASAKKAKKSVSKKDSQKNDKDVKRLEKEIRALLQERGTQDKRIQDMESELEKTEAKLNAAVREKTSLSASNASLEKRLTELTRANELLKAKFSEDGHQ-KNMRALSLELMKLRNKRETKMRSMMVKQEGMELKLQATQKDLTESKGKIVQLEGKLVSIEKEKIDEKCETEKLLEEISCASDQVEKCKVDIAQLEEDLKEKDREILSLKQSLEENITFSKQIEDLTVKCQLLETERDNLVSKDRERAETLSAEMQILTERLALERQEYEKL............................................................................................................................................................................................. 322
40 -13.900PF04582.7; Q9DPB5_9REOV/1-326; Reovirus sigma C capsid protein  ali follow..  11  6..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PLQRREVVSLILSLTSSTTTNPGDLTAVYERLTNLEASTKSLRQSLSSIVSDLSDVSVDLQDTTRALDDAIATLKGLNTTVAALQNSVASLSSTVNGLTDISSAHSEALSFLRTTIDGNTVAISNLKGDVSTNGLNIADLQNRMKSLESSTSHGLSFSPPLSVADGVVSLDMDPYFCSQRVSLTSYSMAKGTSGSSDVIDMTVNAHCHGRRTDYMMSSTGGLTVTSNAVSLTFSLDYITNMPSDLSRLIPSVGFQAASFPVDVSFTRDSATHSYQV............................................................................................................................................................................................................................. 291
41 -13.800PF14662; C9JGW3.1/157-349; Coiled-coil region of CCDC155  ali follow..  17  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QATADLLSSLEDLELSNRRLVGENAKLQRSMETAEEGSARLGEEILALRKQLHSTQQFAKAMDEELEDLKTLARSLEEQNRSLLAQARQAEKEQQHLVAEMETLQEENGKLLAERDGVKKRSQELAMEKDTLKRQLFECEHLICQRDTILSERTRDVESLAQTLEEYRVTTQELRLEISRLEEQLSQTYE.................................................................................................................................................................................................................................................................................................................. 193
42 -13.500PF04094.9; Q8S5S8_ORYSJ/246-1073; Protein of unknown function (DUF390 topsan)  ali follow..  13  379................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TNTTVLDGLSAQMEVLQAERAELDAAWARVEEGRRSVEAMVEAGRKAHRRHTSELEARRRDLAEIAREVEEERETALIATTVLNEARDDLRQYGSRAAELEKKLDAARGVLDAAAARERRAAENEAASRQREEALEARATALEERARAKERDMADREAAVAIREATLAAHEAACAEEESALRLREDTLTERGRALEEAEAAAQRLADSLFLREAAREEARRNLEGARAKRAALDQRVAELEARAKELDARAHGAAVGDGDLAARLAAAEHSIAEL--------------QGALDSSAGEVEALRLAGEVGPGMLRDAVSRLDRAGRQAGLWGGRCAKYAANQGGLAQRLSEMAGTLQRLPEELEETIKS.................................................................................................................................. 737
43 -13.000PF05667.6; CCD22_AEDAE/1-554; Protein of unknown function (DUF812 topsan)  ali follow..  12  250................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SKGGTKHRLAEPSGAAASSGTTEKVVLNNITVETKPGKTPLESLQEEIDALQQEIVQHSEEGVQLESSRKETDESIEEYRKTIVRLKEEKKIKERTHILLEDPEVNVKKLEAIIAAGGERMKKLQDQWDAHRIPLVDTLEAYRLKNSDKLSKSQQVLDQIESTRQKCEEVVIDLQTKGAMYARLQKEFEKLNKTVSRTASRILEIIGNIRKQKNGIDQILQDTRSLQKEINNITGQLDRQFTVTDDLIFRNAKKDEHSKRAYKLLVTLHSDCEE------------IKLVQETGAIKREVRDLEDQIENEKGRN......................................................................................................................................................................................... 554
44 -12.800PF08614.6; A16L1_PONAB/13-207; Autophagy protein 16 (ATG16)  ali follow..  10  2.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KRHISEQLRRRDRLQRQAFEEIILQYNKLLEKSDLHSVLAQKLQAEKHDVPNRHEISPGHDTWNDSQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQRKDREMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKLRKTTEENQELVTRWMAEKAQEANRLNA................................................................................................................................................................................................................................................................................................................. 195
45 -12.800PF15254; G1T8F1.1/39-892; Coiled-coil domain-containing protein 14  ali follow..  12  417.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KTTGSVECNLELFSLQSLNMSLQSQLQESLKNQELLQSKNEELLKVIENQKDENKKYTSIFKEKDQTILENKQQFD---IEITKIKIELEEALVDVKSSKFKLDTAEKENQILGITLRQRDAEVARLRELTRTLQNSMAKLLSDLSVDSARCKSGNNLTKSLLNIYDR------QLQHDPAPAHTSIMSYLNKLETNHSVAHLEPLSTIKNEETTEPDRPYENVLPSKGPQPRNTSGREEEPASGIISALSKQDSDAENETLTVIEDECNLDSTVYIPFVRSTSKMNSPLSRLSPQPQMSVAITQLVG----NSGLVSETEKKLCAHAVTCSSRQEVEDAHEKLSRTADTEDKQLLKKIKEAIGKIPVARED--------------PEATCQGPSACHKSSIRVKGSTACDGSVLNSDLMSDWSISSF--------STFTSLDEQDAALD-ANIARLQKSLR.................................... 848
46 -12.700PF13779.1; A9D7X3_9RHIZ/37-855; Domain of unknown function (DUF4175 topsan)  ali follow..  473....................................................................................................................................................LSLAERRLRDAQNALAEALENGATDEEIAQLMDELREAMQEFLQELARQNQNNPASEMQQAMPEN-RDLDNMLDQIENLARSGARDQAQQMLQELQRMMNNLQAGRQQRQQQQGGPMRQQMDKLGELMRQQQQLMDETMRADRDRQSQSGEGRDRQEQGQNQPGQGQDQGQQGQGSQSLEEMLGALGRSQQELQDALGQLQRDLEGMGINPSEGFGEAGEAMGDAAGNLQQGQTG-----QALGDQGRALQALRQGAEDMMNQMMQAMGNQQGDAEGEGPDQNGNRSADDRDPLGRPRATTGPDFGSRVQVPDEIDIQRAREILDAIRKRLGDQLSPEVEKRYLERLLD.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 819
47 -12.700PF04108.7; ATG17_PICAN/6-396; Autophagy protein Apg17  ali follow..  4..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VADARANLAHAEQVCNDANMYLTSTSEKLRRREMKVPKLIYYLDALKQQLRLLEIIRDSLVLNLNGVMEKRAALQSQLLKDVDRLHQTIDTLKNTVVVFDGQTTLYEYISESGVEELFNGVSQNLKDIQTLIKGNRTDALLIRLTSDLDHLSNELNALDSKFRDMRDPISKLLEINAELEHDMVAILTSFNNHYDQCEKGEAILKDPAVPQDEKDELVSVLQNDVEELPEAQRSLTSNAEIIKKNCKEVMKILDIFEDYFQRVETYVCELQEYGESKLRVQLKEFSDINTELEIAQTHQDELVQYNSDFQQFVRSYYSLILELDRRMRVNEHISSAIDNFRSTISNIVE-----DHEKRMEFLQKHGD..................................................................................................................................... 380
48 -12.700PF14073.1; CEP57_HUMAN/68-245; Centrosome localisation domain of Cep57  ali follow..  11  1................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVL---DEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIF.............................................................................................................................................................................................................................................................................................................................. 178
49 -12.600PF15358; D2H7U7.1/26-586; Testis-specific serine kinase substrate  ali follow..  14  111..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NSGLVRAKDSITSLKEKTTRVNQHVQTLQSECSVLSENLERRRQEAEELEGYCSQLKENCRKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQRQLQDEEAELQELEQKLDAGLSRHGLGPTAQSPGCCGPPGSPNEPPRPRSMAPGGWGMGPRAGEGPIVSEQEMQKVSAGLEELRRQGGGAAREVSSLTARWHQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQAARGLQELRGRADELCTMVERSAVSVASLRSDLEGLVKPILEELGRQFQSSRRGSDLSMNLDRLERALTPLVDEVKQ------PACPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEALR............................................................................................................................................. 497
50 -12.500PF05276.9; Q4SIQ7_TETNG/16-252; SH3 domain-binding protein 5 (SH3BP5)  ali follow..  1....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EEEEVDPRIQGELEKLNQSTDDINRWESELEDGRQRFRAVLVEAMCKLDGLMKRIGRAVDDSKPYWEARKVAKQAQIEAQKATQEFQRSVEILRAAKETIALAEERLLEEDSR-SAWQEMLNHATQRVMEAEQSRTRSEAEHKKTAANYNSSISHMRQLEKKLKRSINKSRPYFELKGKYYLQLEHLKILVNERQAKLMSAKAEYRKALRNLESISEEIHAQRRSVAMGTRE....................................................................................................................................................................................................................................................................... 234
51 -12.500PF09726.4; Q4SIM5_TETNG/2-648; Transmembrane protein  ali follow..  13  13YLKFLVVWVLVLLAD-LEFRFE-----YLWP-------------WLFIRSVYDSFRYQGLSDIIFAASTTERGVCLPTVSLWI----------YIEAAI-------------------RFKDLKNFHVD------GYPVVTLG-----------GFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQQMLQRPEKETEEVTKGISEVEP------------------SVTSQNGAPPGKKSSTLQLPELEYREKAKDSTGKEGKKVGINNNSIIHLDSKLQEAEYIENYAGAKRLNNDLAGENTDSNTHSTSKEEMAGTGKNFKYNSGGGANISNSSPRNHSSSNGSVLSGSTSKNEKKQK-GAGKAQKDPVENCIPNNQLGKPDALVRLEQDVKRLKTDLQANRQLESELRSQLSSLSSQDRSLRSELGPVRQDNELLQNKLHSAVQAKQKDKQTISQLEKRLKAEQEARTLAEKQLAEERKRKKMEEATAAR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------AVALAAATRVESTDSLRSRIRDLETECKKLTMDMKLKEEQIRDLEGKCQELRKY-KENEKDTEVLMSALSAMQEKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQIHQREQEIAELKQKIAEVMAVMPSLSYSSDGSNLSPVTPHYSSKFMDNSPSSLDPNASVYQP.............................................................................................................................................................................................................................................................................................................................................. 646
52 -12.400PF00769.14; MOEH_DROME/332-578; Ezrin/radixin/moesin family  ali follow..  12  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ERAEKKQQEYEDRLKQMQEDMERSQRDLLEAQDMIRRLEEQLKQLQAAKDELELRQKELQAMLQRLEEAKNMEAVEKLKLEEEIMAKQMEVQRIQDEVNAKDEETKRLQDEVEDARRKQVIAAEAAAALLAASTTPQHHHVAEDENENEEELTNGDAGGD----VSRDLDTDEHIKDPIEDRRTLAERNERLHDQLKALKQDLAQSRDETKETANDKIHRENVRQGRDKYKTLREIRKGNTKRRVDQFE.................................................................................................................................................................................................................................................... 245
53 -12.400PF03082.9; MS2A_DROME/1-264; Male accessory gland secretory protein  ali follow..  10  16..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TVASCDSEQQLDSAMHLKSDSTKSASLKNVAPKNDET--QAKIAKDDVALKDAKKGDYIMDIDISDLPLDDYPINRSKSLKSSSIDLNNIPFNKGLDDFPAKEKNQGSNQSALKALQQRLLTEQNNSLLLRNHSIYLMKEIEARKTDIIKVRQLNLDLELELNTVNRRLLELNGQLQNTRKSTKPCKKR--SSKDSAPPAANQFQEANVRNTYRNKYLTLLKELSQKINNEIAKVATDVPTETNPSQG............................................................................................................................................................................................................................................................. 259
54 -12.200PF07902.6; Q1CPP5_STRPB/1-621; gp58-like protein  ali follow..  1...................................................................................................................................MSRDPTLLIDE---SNLTIGSDGRAYYTFKADGDTKSVKLANNKCIGTTRFNQLMIERGGKPTNYVAPVVVEGSGETGLFKNLEGALSQLKELNLELTDTVNSQLWAKIKLTTNGMLREYHRDNITTEIVESANGIATRISE---DTDKKLALINETVSGIRRDYQDADRQLS--STYQAGINGLKATMANDKNDLKAVIQATAQGLQKYDDEIQQLSAKITTTSSGTTEAESKLADLRAEFTRSHQGMRTVLESRISGLSTQQSTAYQISQEIKNREGAVSRVQQDLASYQRRLQDTEKNYSSLTQTVRGLQSTVSAPNRGLESRVTQLAGLIEQKVTRGEMESYIRGAGDSIMLAIK......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 355
55 -12.200PF10473.4; Q9GKN4_CANFA/3-142; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1  ali follow..  17  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EKKQLHVLEKLRESERKADALQDKIENLERELQMSEENQELVILDAENSKAEVETLKTQMELTTKSLKDLESDLVTVRFEKENLIKQLQDKQGQVSELDTLLSSFKGQLEEKEREKIEMKEESRAALEMLRTQLKELNE...................................................................................................................................................................................................................................................................................................................................................................... 140
56 -12.100PF03904.8; YP2A_STAAU/1-230; Domain of unknown function (DUF334 topsan)  ali follow..  2....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RKGQLIMSMKDIKNNKENPNTQMNSKSTGTPSSSTQNSLNNEELSELKRQNKLIVKYLAEIQENQKIREKEQKEITSELKEATKDFRDKSLKIRNDFVDVLQEKLKHVDTEELKDILGRGIYKVREENDRMLQEVKRSHEHYQTRQKYLFTGIGAMLLVFMLFALIMTIGSDFMS................................................................................................................................................................................................................................................................................................................................ 176
57 -12.000PF01496.14; VATM_DICDI/30-807; V-type ATPase 116kDa subunit family  ali follow..  10  11....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QFLDDNEHVNLFQRNFVNEVKRCDDMEKKLKFFEDQVKKEPKLLPDNMLSVVDDDSQMDELEGRFDELESELKQVNANQETLQRNYN----ELIQLRHVLTKDSVFFQENPNLIEGEGHEHSARSPLLAEDQHVSEVAKQGVKLGFITGVMNTDKMPQFQRSLWRTRGNNYVKDARIEEEIIDPQTGEETAKTVFIVFFQGERLQQKIKKICESFGANIYDCPDNSFERSNLLQKVTVRITDLYEVLQRSKDHKRQTLAGIVPRLYSWKKKVLLEKSIYHTMNLFDYDVGR-KDKIEEIQLALRTATTRSGALVPSVLSIIKTEG-THFETNKYTSSFQEIVNAYREVNPAV----------TIVTFPFLFGVMFGDGHGALLLL-------SALGLISLEKKLAGKKLNELIQMPFDGRYVLFLMSLFSI................................................................ 442
58 -11.800PF15818; G3T452.1/26-1067; Coiled-coil domain-containing protein 73 family  ali follow..  2.....................................................................................................................................................................LLDFKTSLLEALEELRMRREAETQYEEHIGKIIVETQELKWQKETLQN----KETLAKQHEEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKLSEMEQKVQLHFLAKEDHHKQLNEIEKYYAIITGQFGLVKENHEKLERNVQEAIQLNKRLSALNKKQEFELCSLKKELKKVTSDLIKSKVTCQYKMGEENTNLTIKERKFQELQERLNMELELNKKINEEISRIQEEKQNVIISFQHMQQLLQQQTQANAEMKAELKVLKENNQTLERDNELQREKVRENEEKFLNLQNEHEEAQGTWKKVEELNGEINEIKNELSSLKETHIKLQEHYNKIYDQKKFEEDKKFQNVPEVSNEHSRMSAEKSEDTTILTYNSGQEIREENS-------------------------------MNFCSDTEYREKKEGPPKEEIIIEDLQLLEKSCKN------------------------PQDENQSEISLSKVLCTDKEVISQGQTLNVPDFRKSITTEIKDKLCLEKDNGCTEFQSPTSLILVADTSIETKMIHLESMGGLDSHHPDVHLEAENHRSCDSILNDNTNHSKDVSENEPFKQQFRLLPCTQKSTAERVMTNTDQTKAELSSLDVKEKPVHWEKCSLHNSSSVMLDDKRCKTKQLLRTQSECGILPLKQTSDFQQLCNDTSEKAQLNIPCDTASSYPISYAAFSDNLKLLENSDKKVSIVPMLVKPNSSPGKRTTRKNLDAQSSQFKDCLERLENN-QPKDMKTAVYRKTSTEIQLSSKDSQIDENQITEATKNDLFLLVNVNERQHSLLNNTEKTESLNDIVSEKIYIEGQLEESRSFHIKASGDSVNT-----------SGMSAFDLSTSD---------------KKT---------EK--TPVYLNF----LDPGTWSKVNQIESQTVSTSASSILSSPKE-SENKKIVSTTLGKNTGVDEVRKGVVRPDTTSINR 935
59 -11.800PF09755.4; A0AUQ3_DANRE/3-319; Uncharacterized conserved protein H4 (DUF2046 topsan)  ali follow..  10  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ADSASESDTDGATPHCSSSSSSSILISSFRLEELSNRLASLQQENKVLKIELETFKLKCKALQEENRDLRKASVTIQARAEQEEEFINTLFKKIQALQKEKETLAVNYEKEEEFLNELSRKLMQLQHEKAELEQHLEQ------EQEFQVNKLMKKIKKLENDTISKQLTLEQLRREKIDLENTLEQEQEALNRLWKRMDKLEAEKRILQEKLDQPVSAPPSPRDTISMEIDSPENMMRHIRFLKSEVERLKKNLRTSELQHTEKRAQY------------------------IEEERHMREENIRL--------RKLQREVERREALCRQLSESESSLEMDDERYFN.................................................................................................................................................... 314
60 -11.700PF10234.4; A7SE98_NEMVE/14-284; Clusterin-associated protein-1  ali follow..  22.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VAEVLIWLVKRYDPNVELPMDVETEQDRVLFIKAVAQFMATKAHNTKKLYGADGYAVKELLKVTSVLYNAMKSNVTDDEAEPSDVTSLTFDISSRISDLKASRQLASEITTALYDLLGHEVELRDIRTRAIAKPLEVNELENGIKKSISLAQDDIRKTTQMLDNIASDEANLEAKIDKKKQELERNQKRLRSLESVRPAFMDEYEKLEEELKKVYETYMEKHRNLSYMEQLLDDVNRAEQDRFE.......................................................................................................................................................................................................................................................... 271
61 -11.600PF15290; H3CN48.1/194-511; Golgi-localised syntaxin-1-binding clamp  ali follow..  10  32.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SCNSSPTSSRRAGLGSYHLCGDNHGVRPPNPEQYLTPLQQKEVAIRHLRTKLLESENRVHDREAEIQDLKTQLSRMREDWIEEECHRVEAQLSLKEARKEIKQLRQVVETMKSSLMEKDKGIQKYFIDINIQNRKLESLLRSMELAQSGTNLQDENTLDFERPNGGGNKLVGEEGHGLEMGEQGVEAMADSGLLINDEIASRVDILEQVFMSTAVDFSQDCKRRADPGVSTLSEDPLMIGEPPKPRSNPISSATSVKQSTEDKGMQTDAMPCSPDLSALVLQLLQ................................................................................................................................................................................................................................. 318
62 -11.600PF06637.6; PLVAP_HUMAN/1-442; PV-1 protein (PLVAP)  ali follow..  12  55................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................STESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKCTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQADKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALE------EKAVLRKERDNLAKELEEK--------REAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVPN............................................................................................................................................. 409
63 -11.400PF15397; G1REG6.1/105-362; Domain of unknown function (DUF4618 topsan)  ali follow..  12  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LRNGRTALRELQSHENFLTKLNEELIETIQDMESSTTLNVRALLQQQDILATIINILE--YSNKKRLQELKSELQEWEEKKKCKMSYLEQQAEQLNAKIEKTQEEVNFLSTYMDHEYSVKSVQIATLMRQLQQVKDSQQDELDDLSEMRRKVLESLSNKIQKKKKKILSSVVAETQRPYEEALLQKMWESQDFLKCMQRFREFIDQFKENMPVLRAEVEELQAQTREPREVIFEDVLLRRPKCTPDMDVILNIPVEE............................................................................................................................................................................................................................................. 255
64 -11.400PF07058.6; MP704_ARATH/209-559; Myosin II heavy chain-like  ali follow..  10  2.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VDDLQNKNQELMKQIEICQEENRIIDKMHRQKVAEVEKLMQSVRELE----EAVLAGGAAANAVRDYQRKFQEMNEERKILERELARAKVNANRVATVVANEWKDSNDKVMPVRQWLEERRFLQGEMQQLRDKLAIADRAAKSEAQLKEKFLLRLRVLEESLKGPTSSSSRGTSVGRSSSNGPTRRQSLGGAETSPKITSNGSLIKRTPS-SQLRSLTASASTVLKHAKGTSRSFDGGTRSLDRSKVLINGPRSNFPLNHKSSEGTSRGESPSSIKGEEESADKATNNDSVPGVLDLLQKEVITLRKAAHEKDQSLRDKDEAIEMLAKKVETLTKAMDVEAKKMRREVAVMGKE............................................................................................................................................ 351
65 -11.400PF15619; E9Q424.1/143-336; Ciliary protein causing Leber congenital amaurosis disease  ali follow..  12  4..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HRILSARLHKIKELKNELADVHRKLEASAIENQFLKQLQLRHLKAIGKYVNSQNNLPQITAKHQNEVKNLRQLLRKSQEKERAVSRKLRETDGELLRTKDVLQALQRLSEDKNLA-DRLTDLTAKMEANDKKIQNLEKQLRLNNRSYSRQLAKENRKTLAAQTATKTLQAEVRQLQQKLKEKDREL....................................................................................................................................................................................................................................................................................................................... 194
66 -11.300PF10498.4; IFT57_XENTR/25-384; Intra-flagellar transport protein 57  ali follow..  33....................................................................................................................................................LPTNPGEQFYMFCTLA-LISKAGHHFDQPQEYDDPNATISNILSELRSFGYSVDFPPSRLKAGYG-EQVCYVLDCFAEEVLKHIHFSWKRPTYPTEEQDEENVIEDDAELTLNKIEDEIAEEDSDNDQEHFIDLNALSAQTQKLNTKESSKPEEILESNTDAAEWILEVERVLPQLKTIRTDNKDWRVHVDQMHQHRDGIDTSLKETKGYLDKLHNEVAKALEKVSSREKYINNQLEQLVQEYRSVQAQLSEAKERYQQASGGVTERTRILAEITEELEKVKQEMEEKGSSMTD-GAPLVKIKQALTKLKHEIVQMDIRTGVVEHTL........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 359
67 -11.300PF16043; A7S4W5.1/475-727; Domain of unknown function (DUF4795 topsan)  ali follow..  1..................................................................................................................................................................................................................................................MQNMKKTLSMQQEDFKKDMEKNKKAIDQLSRELSLFRAARKAQDA---EGFNAVHHVHSMVLELQTKHDKMMATTAELVNEYNRREKVLDELADSIDKLEQKKADKQDVNKNIDIKANKEDLESKVSMNQFDESFNLLDRGLNEALEKMGNQMTIEDALKETLMDLQSKLTLKLDR-NELDNLRAQLESRIKEVQVTRTVIQVKPEDGEPAGFRRN......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 212
68 -11.300PF05010.9; Q2NKK4_HUMAN/638-837; Transforming acidic coiled-coil-containing protein (TACC)  ali follow..  12  1..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAM---EEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEELQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEK....................................................................................................................................................................................................................................................................................................... 200
69 -11.300PF15233; G3QLD7.1/46-198; Synaptonemal complex central element protein 1  ali follow..  12  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQDTLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAREICALDSSKEQLLME..................................................................................................................................................................................................................................................................................................................................................... 153
70 -11.300PF13870.1; B4J5C0_DROGR/499-675; Domain of unknown function (DUF4201 topsan)  ali follow..  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MSQKRNEISDDRLYLISRKHTLGRITDKITKLEQINEDLCDDFINIQNQVAALDKKIEERNNDLKKLRLNYHTELHLTQHNREKALALDSKLDVAKLNLEIMQKKQDQLRECLYKAKLERSNIRKVHSDLSFQGGLLSMP--ALMFDYDETVERVRAKQASVKELKETFKHITQRILE............................................................................................................................................................................................................................................................................................................................ 177
71 -11.200PF01540.11; O53101_MYCHO/1-353; Adhesin lipoprotein  ali follow..  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MKKSKNIFITLCGIAATAILPVATISCNDDKLAEKNGKEKADAALKQANALVEELKKNPDYSKILETLNKEIAEATKSFKEAGSYGDYPAIISKLSAAVENAKNEKKAIDDKNAQIAKELAERNAKIQSNIEELKKINNEAFELSKTVNKTIAEVEKKFKIEASFKEQLENFADDLLDKSRQIDEFTTVTSQEGFTLAELESFKEITTTWFNGMKSEWARVLDAWKNELTEINSIIKGVEELKKLSHEISEFSNSVKKTISELEKKFKID-----------------DKTNKDEAKQFKNELENF--------DQLLNKSHEIDKFVTVTSAREDFSLSELESFKSFNTTWFNEMKCEWARVQEAWKDQLKEI......................................................................................................................... 350
72 -11.100PF06785.6; Q5L4N7_CHLAB/1-401; Uncharacterised protein family (UPF0242 topsan)  ali follow..  11  4...................................................................................................................................................................................VKKIFHPIARYHNYLFPIVAFLLPLVCLPFLSNSQKKYSYFVFSII------------SLVGWFFSIGLREKQLKTAAGQLLQTKIRKIIEKDEGLRKICESVEERQYESQQLRSQNQKLLNQLLHVRGVFMKTKSDMQKLEGLVAHLREENQCLQLQLDALSQECREKEEESRELNRELAEALAYQQVLNEEYQATFTEQHNMLDVRQVYIGKLESKVQDLMCEIRNLLQLESNIVENLPR--HAIATSQELPKQLLSELKKIAFKMENIEAASSLTASRYIRSESSVYNYSLECRQLFDNLREENLGMLFVYAPQSQ................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 308
73 -11.100PF05335.8; Q8T4I3_DROME/75-260; Protein of unknown function (DUF745 topsan)  ali follow..  3.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LSQKNAKSKASSIAIKAAQDAKAANDAQMAAGEAASLQVKQDLAEKAVQARAAEAALAGKQQIMEQLELEEKEAVAVVDEVKNSLHSTQVNAESAMLAFSEAKIQLDQLKVLLAEATAQMTNIETFANGAQLEMDEKGQLLEAANRRVESISRQVVAARQDYDKTKKAAYKAACAAVEAKQK........................................................................................................................................................................................................................................................................................................................ 185
74 -10.900PF11398.3; Q6D3T4_ERWCT/1-377; Protein of unknown function (DUF2813 topsan)  ali follow..  21  2HLESIEILGFRGINR-LSLTL-DENNVLIGENAWGKSSLLDALSLLLAPTLPLY----DMQDFHFTPGDENSREKHLQIIFTFCETA............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 84
75 -10.700PF14817; B5X4P2.1/5-647; HAUS augmin-like complex subunit 5  ali follow..  77................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SDAAKRFELQEQIEELRVELNHLDSQINGTEAQLVTEEESINRSWEMVEENQCRELLLQAFKQRCMKERHSLSEDIHKISGHSQVLEQLSRRAEMKVVFGNETSNSSGDHLNPSGAEPKVLR-NVRELCDERLQFFQSLQESELNMTSSTATHLTREQRTALFRHWLSAVEDLLQCPNQVLSALQYLALGQEMTLEEMLASLDVARDVAALRFRYESNHLPDISKEEEELPPVKSLLQSAWEEVEQSLMELAQTRSRIQLLQTQLHARKKEAQLELIGGESQTEA----SQSVFKLEMQCGIQAAVRNSLRDQCVQMEQHARDRQEDLRNLRSQWQNIMDFRQLGDVRQEQIRGLIKG............................................................................................................................................. 432

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Bourne PE, Allerston CK, Krebs W, Li W, Shindyalov IN, Godzik A.,Friedberg I, Liu T, Wild D, Hwang S, Ghahramani Z, Chen L, Westbrook J. The status of structural genomics defined through the analysis of current targets and structures. Pac Symp Biocomput. 2004;:375-86.