current user: public

anford Burnham Prebys Medical Discovery Institute
We are hiring bioinformatics experts and software developers. Join us!

Query: gi|15644646|ref|NP_206815.1| hypothetical protein (HP0013) [Helicobacter pylori 26695], from H.pylori

Results of FFAS03 search in COG0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350
# Score Template Links and tools%idFirst MKKIKALALFSGGLDSLLSMKLLIDQGIEVTALHFNIGFGGNKDKREYFENATAQIGAKLLVCDIREQFFNDVLFKPKYGYGKYFNPCIDCHANMFRNAFYKMLELNADFVLSGEVLGQRPKSQRKEALNQVRKLVREVGEEARFDPVLDRTQAGGKKPQFLDELLLRPMSAKLLEPTFMEKKGFVDREKLLDVSGRGRSRQLQMIKDYGLKYYEKPGGGCLLTDIQVSNKIKNLKEYREMVFEDSVIVKNGRYFVLPHNARLVVARNEEENHKLDIQHPLMDKIELLNCKGPLSLVDKNASKEDKELAGRIALGYAKTLKNQAYLIQIGDEKRELYPLDKENAREYLFALast
1 -56.100[J] COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain  ali follow..  16  22.RKKKVICGMSGGVDSSVSAFILQQQGYQVEGLFMKNWYCTAAADLADAQAVCDKLGIKLHKINFAAEYWDNVFFLQEYKAGRTPNPDILCNKEIKFKAFYAAEDLGADYIATGHYVRRGEKDGQCQLL----RGLDNNKDQSYFLYTLSKDQV---------AQSLFPVGEKPIVRAIAEDLGLATAKK------------------------KDSTGICFIGERKFKDFLARYLPAQPGEIRTVEGKVVGRHDGLGEDPFYVVEKDLVNNVLVVAQGHDNSALLSSGLASQLHWVDRQPIRQPVRCTVKT--RYRQEDNDETIRVVFDEPQIAVTP--GQSAVFY... 367
2 -53.300[J] KOG2805 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase  ali follow..  18  4.KPLRVAVLLSGGVDSSVALRLLHAAGHSCTAFYLKIWFCPWEDDLKYAKHVCEQVDVPLEVVHLTDEYWERVVIIEEYRCGRTPNPDVLCNTRIKFGAFDAISDMEYDYVGSGHYAKVHPPADQNDASSVLELSQDMVKDQTYFLSHLSQTQL---------KRLLFPL-------------GCVKKDEVRKL---ATQFDLPNKDR------KDSQGICFLGKIKFSDFVCRHIGEMEGIILEAEGDFLGNHLRLPGGPWYVVEKDTKNNVVFVSRNYYSIDKRRRIFVGSLRWNSGKPSGKVRELRCKV--RHGPGGDGDVAVVHLDEDDQGLAA--GQFAAFY... 352
3 -34.600[J] COG2117 Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain  ali follow..  14  2..LGDVYHLFSGGKDSSLAAWILRKLGYEVRLVTIT---FGVLDNWKYAKETADILGFEHEVVRLPRELLNMAV--EMCIEDGKPGRAI-----------QFLHEKALEYVASRSYVK-------------RISDGTRRDDKVPFLDLRKARSL----EDRFNVAYIRPLL------------------------GLGYKTIRELANSIFVIEERESEK---LEKGDYEAELRYMLRERGINSRHMQSRVVGIKDDE............................................................................................. 202
4 -27.800[R] COG1365 Predicted ATPase (PP-loop superfamily)  ali follow..  21  54.INVKIAVAYSGGSDSSATVKILRWAGFDVVPITARLP----HISKEKLREETLFVEVPGYLEEMEK-------------IEKRAPICGRCHSMVMRAVEEKVRELKIRILATGDMLS........................................................................................................................................................................................................................................ 154
5 -17.200[R] KOG2840 Uncharacterized conserved protein with similarity to predicted ATPase of the PP-loop superfamily  ali follow..  14  49.RGEKVAVAASGGKDSTVLAHVLKLYGLELVLLSIDEGITGRDDSLETVKQNRDDYQMPLKILSYEELYGWTMDRIVAQIGRS--NNCTFCGVFRRQALDRGAKLLGVDSIATGHNADDIAEGGGEDTIPRVKPLKYSYEKEIVHYKKLVYFSTECVFAPNAYRGHARAFLKDLEKVRPSVIMDIIYSGEQLRFKDTVKKPERGTCTRCGFVSSQQPCKACVLLEG............................................................................................................................ 303
6 -15.800[R] COG1606 ATP-utilizing enzymes of the PP-loop superfamily  ali follow..  19  13.SKKKLVVMFSGGVDSTLLAKLAREVGKNAVALTIDSPVI-PRKEIEEAKNLANLIGIRHEFIELNELKSRHLIENP-------PDRCYLCRKLRDNIVKNWARENGFDVIADG--LNFSDLQDYRPGVKASTEDG-----------------------------IWHPFID----------------------FEVTKEEIREYSKKLGLPTWDKPAMACLCSRFPYGFGLNE.................................................................................................................... 185
7 -15.500[H] COG0301 Thiamine biosynthesis ATP pyrophosphatase  ali follow..  20  208.TQEDVLSLISGGFDSGVSSYLHIKRGSKVHYCFFNLGGPAHEIGVKQTAYYLWQKKVRFIAIDFAPVVAEILEKIDDGQMG------VVLKRMFMRTAGMVAEKFGIQALVTGEALGQ--SSQTLTNLRHIDNVTDT---------------------------ILRPLIN-------------WDKEDI-----------IRLAREIGTEDFATMPEFCGVISKS........................................................................................................................... 382
8 -12.300[R] COG0603 Predicted PP-loop superfamily ATPase  ali follow..  16  2...KRAVVVFSGGQDSTTCLVQALQQYDEVHCVTFDYG---HRAEIDVARELALKLGAAHKVLDVTSSLTRDSIPVPDYEPEADGIPNT--NILFLTLAAIYAYQVKAEAVITGDFSGY---DCRDEFVKVLNHAVSLGMAKDIRFET--------------------PL--------------WIDKAETWALADY----KLDLVRNETLTCYNGIKGACNLRANGLNHYLAD.................................................................................................................... 216
9 -12.100[R] COG2102 Predicted ATPases of PP-loop superfamily  ali follow..  12  1...MRSAVLYSGGKDSTMALYHALQESEVEFLVSVIS-HMYHVPNIHLTALLAEAVGIPLIESRTAGVEEEEV--------------------EDLAGTLKTLRERGVEAVYSGALYSEYQKSRIDSICRRL--------RSVAPLWHRDPLDYMEEIVDLGFRVMVTAVAAEGLDESWLGRI--VDRKMIDELADLSERYGINPAFEGG............................................................................................................................................ 183
10 -11.900[R] KOG2316 Predicted ATPase (PP-loop superfamily)  ali follow..  11  1...MRVAALISGGKDSCYNMMQCIAAGHQIVALANLRPAENQVGSDE-IDLYAEAMALPLYRRTIRGRSLDTRQVYTKCEGDEVED--------LYELLKLVKEKEEVEGISVGAILSDYQRIRVENVCKRL--------QPLAYLWQRNQEDLLREMISSNIQAMIIKVAALGLDPD--KHLGKTLDQMEPYLIELSKKYGVHVCGEGG............................................................................................................................................ 203
11 -11.100[D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control  ali follow..  15  16.KGATIIVGVSGGPDSMALLHALCGRSANVIAAHVDHRFRGAESEEDMVQAYCKAEQLVCETAQIN---------VTAYAQEKGLNKQAAARDCRYQFFEEIMSKHQADYLALAHHGD----DQVETMLMKLAKGTLGTG--------------MQPVRRFGTGRIIRPF----LTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLP....................................................................................................................................... 206
12 -10.600[E] KOG1706 Argininosuccinate synthase  ali follow..  22  3.SKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANI---GQKEDFEEARKKALKLGAKVFIEDVSREFVEEFIWEDRYLLGTSL-----ARPCIARKQVEIAQREGAKYVSHG--------------------ATGKGNDQVRF-----------------------ELSCYSLAPQIKVIAPWRMPEFYNRF--KGRNDLMEYAKQHGI........................................................................................................................................... 169
13 -10.200[S] KOG2594 Uncharacterized conserved protein  ali follow..  13  58.KSKRAMLAISGGISSMAMLETARPMFDELLAVHFQWGTDSAVAKTIEESISKNYPKCPFKVIGEAELL-ADNEKFNPEVISSLASRQDLLYRIRDKLLVSYARKANCDTIVFGD-------SGTTIAARVLELVAEGRGFA------IPWYTSVCSKLPNCDTFLLRPLGLAFCDSLIEARPNTIHESYFSSLNDTFPSLVSTVVKMSSKLHVPSTEAICTI............................................................................................................................... 309
14 -9.870[F] COG0519 GMP synthase, PP-ATPase domain/subunit  ali follow..  13  19VGSSKVLLGLSGGVDSSVVAALLHKAGDQLTCVFVDNGLLRLHEGDQVMAMFAENMGVKVIRANAEDKFLGRLAGVADPEEKRK----IIGRTFIEVFDEEATKLQDVKFLAQGTI---------------YPDVIESAGAKTGKAHVIKSHHNVGGLPEDMQFELVEPLREKDEVRKIGLELGLPYD---VRILGEVKKEYADLLRQAD............................................................................................................................................ 222

FFAS is supported by the NIH grant R01-GM087218-01
1 1 4 9 9 6   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster

Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.