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Query: [O] COG4934 Predicted protease, from COG0516

Results of FFAS03 search in COG0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKIALSAAIVLVMLFSAVYVAFNSNAGQTNQNSLNSLFSQPLVKSNDNIAKTVEKAGFKPYVPVNGSMEMNVIIGIIPNNLNELENYATEISMPGSPLYRHWLTTQQINSMFGNYQGVETVSSYFSKLGFSVQVKTPFAVAISGNASMMESVFHTTIYYFTNKNGQVLFSNLNSIELPGSVARYVLSVDGLSNFQMTTNPVYPTLSDYTSSGLIKNFEPLSSGTQSYLNHSDVVGFYAKKYAWVQLPLTNGPYPGSNVTGYTPPFQALFPSDLPWIYNIAPGLNGTSSTPGANGTGTTIAIVMGTGYINATLAYPAWNYNDMLKYGKEVFDNPSQILSRVTYLNAPGITHSPPPDPSPSFYVPYTDGYLGEFTLDTQYSATVAPDAHLDIMAIPSLSTVALDNAYITLYELPNTPQVITNSWSGSEDSWWNMYGPYWQSADLMNLLFELLSMKGSTIVAATGDSGGYDGYTNMISGEFPGTSPWVTGVGGDQVTMFNNTGVEFPVTGNYSRFNVTFGTANYSSLPPYYWSNLRLNIVNIGLKHNNGFTQTYWDNNQYVVVNGAPEVISTGAGSAALSIFFKQPWWQHGYSVPNTGRMSEVEVSAEAGFNQTELVDGMWGSWFFGGTSEATPTTAGMIADVISYLNATIHVNYLGDINPLLYEIGNEYMQNPGKMPDPYFTVSNGTNSLSALMVNDSYTLDGPQNYPSNYYTTDNGYSMLTGWGTINVGNFKIDLEQFLTQPFNVTEDNSTGTGTPFYGNFTESTYITMGQPAGLQYGTQYLFNVSGSVSGLTNIPKNLNLTFITSNGEYNLNNSNKPGNMHFAYNAGLLKIYSDTFNTTGFLEVNGTFDHRLAYSFTWIGSKQIANATNNISVEKNMSVSIAYPYLMAGFPAFAYTGLFNGTAGYFATYVPPIEPNMQIVNVTYKGKPVYNALVLLTYKNASNEIKNLTFLRQYAISYSFTNLNGSAYLDTWNVAVDTKAYVYVVYSGMVKESNFTLTPQSTSSILFNNSLESILLPYYNLLPVFQGQYLPFTVNQENAEVALYVPGSLNFYGPSTPTTVIPSTITNTNAKGFVNFKIPNWLPPGSLLYLGITNSSQPVYSAANGLILDHNVSYLPVYVAGSGPSVMLASNALTNIFGVPVVTPTTSFEAVYTDSLSPYGGYVNYMWYSVDGMTPISFGQDGYAVAAASQTQIFGLNSSIPSGLNTLYVYFNDTLGLTYETSMEFYFNASIPTPSLMLSSPSYYEHGNFSVSYKDNLNPNLTILNELYISYNGNIIASEPITTSSGVLQINGNDLPYGILNLTFTIETANGQTNETSITVMNLPADEYYPTVNIIAPVTGSSQTGSLNITFTYTGFDDTVILYVNGSSGNVITANVTGKNLYTITEGKGSSSLPAGNYTVTVLVISKDGQVAKQSANFDLKAPVVPPVQSSIIIEYLVIGIVGGLIVGSLAVVAVMRRHLast
1 -452.000[O] COG4934 Predicted protease  ali  100  1MKIALSAAIVLVMLFSAVYVAFNSNAGQTNQNSLNSLFSQPLVKSNDNIAKTVEKAGFKPYVPVNGSMEMNVIIGIIPNNLNELENYATEISMPGSPLYRHWLTTQQINSMFGNYQGVETVSSYFSKLGFSVQVKTPFAVAISGNASMMESVFHTTIYYFTNKNGQVLFSNLNSIELPGSVARYVLSVDGLSNFQMTTNPVYPTLSDYTSSGLIKNFEPLSSGTQSYLNHSDVVGFYAKKYAWVQLPLTNGPYPGSNVTGYTPPFQALFPSDLPWIYNIAPGLNGTSSTPGANGTGTTIAIVMGTGYINATLAYPAWNYNDMLKYGKEVFDNPSQILSRVTYLNAPGITHSPPPDPSPSFYVPYTDGYLGEFTLDTQYSATVAPDAHLDIMAIPSLSTVALDNAYITLYELPNTPQVITNSWSGSEDSWWNMYGPYWQSADLMNLLFELLSMKGSTIVAATGDSGGYDGYTNMISGEFPGTSPWVTGVGGDQVTMFNNTGVEFPVTGNYSRFNVTFGTANYSSLPPYYWSNLRLNIVNIGLKHNNGFTQTYWDNNQYVVVNGAPEVISTGAGSAALSIFFKQPWWQHGYSVPNTGRMSEVEVSAEAGFNQTELVDGMWGSWFFGGTSEATPTTAGMIADVISYLNATIHVNYLGDINPLLYEIGNEYMQNPGKMPDPYFTVSNGTNSLSALMVNDSYTLDGPQNYPSNYYTTDNGYSMLTGWGTINVGNFKIDLEQFLTQPFNVTEDNSTGTGTPFYGNFTESTYITMGQPAGLQYGTQYLFNVSGSVSGLTNIPKNLNLTFITSNGEYNLNNSNKPGNMHFAYNAGLLKIYSDTFNTTGFLEVNGTFDHRLAYSFTWIGSKQIANATNNISVEKNMSVSIAYPYLMAGFPAFAYTGLFNGTAGYFATYVPPIEPNMQIVNVTYKGKPVYNALVLLTYKNASNEIKNLTFLRQYAISYSFTNLNGSAYLDTWNVAVDTKAYVYVVYSGMVKESNFTLTPQSTSSILFNNSLESILLPYYNLLPVFQGQYLPFTVNQENAEVALYVPGSLNFYGPSTPTTVIPSTITNTNAKGFVNFKIPNWLPPGSLLYLGITNSSQPVYSAANGLILDHNVSYLPVYVAGSGPSVMLASNALTNIFGVPVVTPTTSFEAVYTDSLSPYGGYVNYMWYSVDGMTPISFGQDGYAVAAASQTQIFGLNSSIPSGLNTLYVYFNDTLGLTYETSMEFYFNASIPTPSLMLSSPSYYEHGNFSVSYKDNLNPNLTILNELYISYNGNIIASEPITTSSGVLQINGNDLPYGILNLTFTIETANGQTNETSITVMNLPADEYYPTVNIIAPVTGSSQTGSLNITFTYTGFDDTVILYVNGSSGNVITANVTGKNLYTITEGKGSSSLPAGNYTVTVLVISKDGQVAKQSANFDLKAPVVPPVQSSIIIEYLVIGIVGGLIVGSLAVVAVMRRH 1459
2 -22.400[O] COG1404 Subtilisin-like serine proteases  ali follow..  15  80................................................................PNQIEEAIAQARANQNVAFASHAYTVKDNPGTFVY----LSDQITIQFAPKLDAVKITLIASQFNLVEDKP-PNAFVFLVSKQATENPV--KIANQLQSIPEVLAAE------PNVLIQTETHYKPSDNLYPQQWYLNHNGGNELVASS----------------------------------------------------------AVEQAWDI-----------TRGVRSVVVAVVDDSDLNHPDFQGSGKIVAPRD---------------------LRENDFLPLPSEKERSHGTACAGIALAEE-NGAGIVGVAPGCALMIRTTGFLDDESIEQIFNWAMEKG--ASVISCSWGASAVYFPLSLRQRAAITRAATR----RNGKGCVVLFAAGNANRPVSGAVTDWLNGFGVHPDVMTIAAST------------------------------------------------------------SMSKKAAYSNWGLNISLCAPSNNASPGMSFPEYTQPSIKTNLSGLGMLTTDIVGAAGYD----PGNFTSNFGGTSSATPVVAGVAALVLS-------------VNPDL-QVKRILETTADKIVDPDPDPQLGLSEGK----------------------DENGYSQWFGYGKVNAARAVQVAFQ................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 571
3 -13.800[O] KOG3525 Subtilisin-like proprotein convertase  ali follow..  11  21......................................................................................FTIEHDSICDESIGACGEPIHTVIRLAKRDD-ELARRIAADHDMH----------------VKGDPFLDTHYFLYHSETTRTRRHKRAIVERLDSHPAVEWVEEQRPKKRVKRDYILLDNDVHHSNPFRRSVLNRDGTRRAQRQQPQSPREIPSLPFPD------------------------PLYKDQWYNVRQAW-----LQGYAGRNVSVSILDDGQRDHPDLAANYDPLASTD--------------------------NDHDDDPTPQNNGDNKHGTAGEVAALAG-GVGVAFKAKIGGVRMLDGAVSDSVEA-ASLSLNQDHIDIYSASWGPEDDG---------KTFDGPGPLAREAFYRGIKFVWASGNGGSRQDSCS----DGYTTSVYTLSISSAT--------------------------------------------------------------------------------YDNHRPWYLEECPSSIATTYSSADFRQPAIVTVDVPGG---------TDKHTGTSASAPLAAGIIALALE-------------ANPEL----------------TWRDMQH-----------------VLRTANWKPLENNPGWSNKFGYGLIDGGALVNMAKTWKTVPEQHICTYEYRLANPNPRPIVGRFQLNFTLDVNGCESGTPVLYLE------VQVHATVRYL----RGDLKLTLFSPSGTRSVKWPFLSVQQWGEDPRGTWLLMVESVTTNPAATG............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 614
4 -11.900[R] COG3889 Predicted solute binding protein  ali follow..  470....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IGGGGDIYGNMVMRAI-PATYVNPATGDVMPGRCTFKVERGPFTIPKNAIAGEKAKVRVTYTCKDGTPMTMEKAAIAFSYEWSYKDGDNDPYYDEAMGASTRTLEQT-PTTYIVYSNITHP------VADDQIAGNNAWWATVPWYLRHAMEELVANPQKYGVTNNYTFT---QAEGPRWLDLLVKDHVEDLKKVIEKLIEEKDVPWYLQGEITPD-----EAVKAYKSLLDFINKHGHAY-------------DSNGPFYLDKYDPDKMLMVFKRKKTLLIARLVPKGAEVPARVMAKPLTVKVMLTLKEEDRGYVTVSIGNEVYSGEAKLTTAGTFELNVPGDTKGWSTGKYTAIIRGGLSKTSPQQTTTSTPQQTSSPTATGTSPTETTTKGGICGAILVGLAVLPLLLRRR 929
5 -11.500[O] KOG1153 Subtilisin-related protease/Vacuolar protease B  ali follow..  13  204.....................................................................................................................................................................................................................................................................................................GKGVTSYVLDTG-----------TEHEDF------------------------EGRAEWGAVIPANDEASDLNGHGTHCAGII-KHFGVAKNTKIVAVKVLRSNGEGTVSDVIKGIEKEFKGSTANLSLGSSKS-------------LAMEMAVNAAVDSGVHFAIAAGNEDEDACLSS------PAGAEKSITVGASTF------------------------------------SDDRAFFSNWG---------------------------------------------------------TCVDVFAPGINIMSTYIGSRNATLSLSGTSMASPHVAGILSYFLSLQPAPDSEFFNDAPSPQ------KEKVLKFSTQGVLGDIGDDT...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 461
6 -10.200[R] COG3291 FOG: PKD repeat  ali follow..  11  385.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DFGDGITSKHARTATHTFTNPGTYD------------VSLTVTNAAGSSTVNKSYISVTPPQAPVADFFSPEVNDLRDFGESIPINETVSFIDNSTGSPMSWLWDFGDGATSTARNPEAYSARGGYTVNLTVTNSFGS----------------NTTSKYGYVLVGVIDAPAIPAYFSSDVRSGNAPLTVTFVDDLDAESPNYPIW--DGVVQTYMVDDNDSATPYAMHVYKKPGKYTVTLYMDNRGGNSIITKYHYITVT-----DPNATVVNFSANVSSGPAPLVVLFTDTS-------TGPAPSSWL--INSKHAMNATHTFTEP----GNYTVSLTVENSAGNNTVTKTDY......................................... 705
7 -9.980[S] COG1470 Predicted membrane protein  ali follow..  346.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GETKVVNLILEIPRNASL--GYYESKISFTVRKSNITLGVNIYKTYKGQKATLKLILVDDTGSPVPKALVKVGNESYATDSTGTLEVEMNPGKYVITIEKEGYETKKEEVELGDGEKKELKLLLVREPYYFNVEA-------QSDIYPIVMEGLSRPFTIVIENLGKSDDEYKLEIRTKVKVKSGETKTVYLKVYPSLNAMPGTYNATITVISSSGIKKEIPVKIKLIGSYNMNVNLLNYRLTITAGEEKTAMMDIFNFGNNLKITVKGPQGWDVKVDPSQIPSGRERVTITVKPEGTPAGDYRVQITV-KADQAEWQDTLRVVVRQR------------------STSTYIGVLILIISFRR. 728
8 -9.780[A] KOG2217 U4/U6.U5 snRNP associated protein  ali follow..  550............................................................................LEIKTKLAGKRLETLEDTNLQLASDTYSAEELAKFKKPKKKVKKLRQKLKAEDLAPLAMGEASGSSDFGSDDLERVLAKARKLKQKENIIKKPLPVDFESIQREIKPEHVEDTASGVVLTGVDGNIVLNATAEFCRTLGDIPTYGMAGNRNEDSNDMMDFDKTEQPEEHMETHTDEPALSHGTWNSVNPDEVMQPADLDNLGEDLEDRAILDEEPDAGVANALRLALSKGYLEKEEKNRPSNTKMAHLQAKNYSIEDKAAGED--------------------EKVGRRDRFHFGPITDFKDKETFKPNVKLDYI-----------DDNGRILNLKEAFRYLSHKFGKGPGK------------NKIEKRLKKMEQDGLMKTMSSTDTGTLTMLQQKQK----TKTAYVVLSGNNKNVPGVSGS............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 958
9 -8.510[S] COG3330 Uncharacterized protein conserved in bacteria  ali follow..  294......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LWAAPNVSGLNMSGIGMGYGLSSREFMASEAPVRPRQFWLVADA---ELIVYGATEPDATVTIGGRPIKL----NEDGTFRFQMS-----FQDGLIDYPIVAVAVDG-TRNVHMKFTRETPSRNTNTKE............................ 411
10 -8.500[R] COG2373 Large extracellular alpha-helical protein  ali follow..  239......................................................................RFDLNPARNTREKLLLPLGDIKPLQQA--GVYLAVMNQAGRYDYSNPATLFT--LSDIGVSAHRYHNRLDIFTQSLENGAAQQGIEVSLLNEKG--------------QTLTQATSDAQGHVQLENDKNAALLLARKDGQTTLLDLKLPALDLAEFNIAGAP-----------------------------GYSKQFFMFGP-RDLYRPGETVILNGLLRDADGKALPNQPIKLDVIKPDGQVLRSVVSQPENGLYHFTWPLDSNAATRMWDFHVEDFMPERMALNLTGEKTPLTPKDEVKFSVVGYYLYG-APANGNT-----------LQGQLFLRPLREAVSALPGFEFGDIAAENLSRTLDEVQ---------LTLDDKGGSLLESGGR-GIRPQFASKSVYDYRTDST-IVYSDGVKKAVSGQFDQKDLIENEQTLDLKADETGKVSFPVEWGAYRLEVKAPNEAVSSVRFWAGYSWQDNSDGSGAVRPDR---------VTLKLDKASYRPGDTI---------KLHIAAPTAGKGYAMVESSEGPLQGLDLTIPVDKTLSTLVVRPGDKSRSATPVGVLHLPL-RLDLALETPAKMRPNQPLTVKIKASTKNGEKPKQVNVLVSA---------VDSGVLNITDYVTPDYGQVIEGQGRLAALRFGGDGDELKRGGKPPVNHVNIVVQQALPVTLNEQGEGSVTLPIGDFNGELRVMAQAWTADDF-------------------------------------------------------------------------------------------------GSNESKVIVAAPVIAELNMPRFMASGD---TSRLTLDITNLTDKPQKLNVALTASGLLELVSDSPAAVE---------------------------LAPGVRTTLFIPVRALPGYGDGEIQATISGLALPGETVADQHKQWKIGVRPAFPAQTVNYGTALQPGETWAIPADGLQNFSPVTLEGQLLLSGKPPLNIARYIKELKA--YPYGCLEQT---ASGLFPSLYTNAAQLQALGIKGDSDEKRRASVD-NGGFALWDKNGDEEYWLTAYVMDFLVRAGEQGYSVPTDAINRGNEIPYADNLKASKFAVQSYAALVLARQQKAPLGALREIWEHRADAASGLPLLQLGVAL--KTMGDATRGEEAIALALKTPRNSDERIWLGD-YGSSLRDNALMLSLLEENKLLPDEQYTLLNTLSQQAFGERWLSTQEFLAARTIQDLPGKWQAQTSFSAEQLTKAQNSNLNSDQLVTLQVSNSGDQPLWLRMDASGYPQSALQIERHILGTDGLRSGDLVLVWLQVKASNSVPDALVVDLLPAGL.................. 1555

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Friedberg I, Jaroszewski L, Ye Y, Godzik A. The interplay of fold recognition and experimental structure determination in structural genomics. Curr Opin Struct Biol. 2004 Jun;14(3):307-12.