current user: public

anford Burnham Prebys Medical Discovery Institute
Please be advised that due to the planned maintenance our websites might be temporarily unavailable on December 17-18, 2018. We apologise for the inconvenience that this may cause.

Query: [KG] COG1940 Transcriptional regulator/sugar kinase, from COG0516

Results of FFAS03 search in COG0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .
# Score Template Links and tools%idFirst MNHSMIISTALSLNLAGMITNCRRPCIANPVVRLYAIDIEKNKESTVRIGIDLGGTKTEVIALGDAGEQLYRHRLPTPRDDYRQTIETIATLVDMAEQATGQRGTVGMGIPGSISPYTGVVKNANSTWLNGQPFDKDLSARLQREVRLANDANCLAVSEAVDGAAAGAQTVFAVIIGTGCGAGVAFNGRAHIGGNGTAGEWGHNPLPWMDEDELRYREEVPCYCGKQGCIETFISGTGFATDYRRLSGHALKGSEIIRLVEESDPVAELALRRYELRLAKSLAHVVNILDPDVIVLGGGMSNVDRLYQTVPQLIKQFVFGGECETPVRKAKHGDSSGVRGAAWLWPQELast
1 -120.000[KG] COG1940 Transcriptional regulator/sugar kinase  ali  100  1MNHSMIISTALSLNLAGMITNCRRPCIANPVVRLYAIDIEKNKESTVRIGIDLGGTKTEVIALGDAGEQLYRHRLPTPRDDYRQTIETIATLVDMAEQATGQRGTVGMGIPGSISPYTGVVKNANSTWLNGQPFDKDLSARLQREVRLANDANCLAVSEAVDGAAAGAQTVFAVIIGTGCGAGVAFNGRAHIGGNGTAGEWGHNPLPWMDEDELRYREEVPCYCGKQGCIETFISGTGFATDYRRLSGHALKGSEIIRLVEESDPVAELALRRYELRLAKSLAHVVNILDPDVIVLGGGMSNVDRLYQTVPQLIKQFVFGGECETPVRKAKHGDSSGVRGAAWLWPQE 348
2 -19.900[G] COG0837 Glucokinase  ali follow..  15  1...........................................MTTYALVGDVGGTNARLALCAVATGEILQAKT-YSGLEYESLEDVIKQYLSEHQAKVTDAC---IAIACPITGDWVAMTNHT---------IAAMQQNLGLDLEVINDFTAVSMA-LQFGGTQPQPGKPVAVYGAGTGLGVAHLVNVDRRWISLAGEGGHVDFAPNSEEEDQILAVLRQELGHVS-AERVLSGPGLVNLYRAIVIEKLAPKDITARALADCTDCRRALSLFCVIMGRFGGNLALNLSTGVYIAGGIVPRFMEFFKARAAFEDKGRFKDFLQDIPVYMITHPQPGLLGAGAYLRQK 316
3 -16.300[G] COG2971 Predicted N-acetylglucosamine kinase  ali follow..  16  2........................................TNAPMPYLIAVDGGGTGCRALLAKADGNVISKAV-ANIGADTAMAIANVMETVTRAVHDAGDETGAVLGLAGANSIPDRLELVAGLPF---------------AWVRIVSDTVTALQGALGDNDG------AIVILGTGSAFVRQVQGTAES-----IGGRGFM-----------SDHAGGARLGRELLEETLLAFDGLTEAVMVRFNDDLRAPLVFEYVAKGDPLGLSIAERACAYIKKGLDRLEVETLGRFSLTGGLASSYAALPFLPYPALYHPPLGDALEGALSLAMLANRWG........... 293
4 -15.000[S] COG4020 Uncharacterized protein conserved in archaea  ali follow..  13  1.............................................MTFIGVDHGTTAMRFALIEDEKVLTFE-RAEAAAMSEKEILAAIEREFGIRIGDIDLVAL-SMGDGFSAIKDVRKLEGRGLQSIEGAGKKTGGGTRVFDAVRNSE-TSPEKLGIAYHILCLGYEDFVVSDISSNTVTLAVVAGKVIGAIDACIFAPGVHH------GPLDLQAIRNVDDRLQTANQAFIEA-GTLKMTPYK-----DREELLKAAGKGEKPALLALDTIALFAAMEIASMQLLMKTGTVFLAGSVGEVEYVQKKICTHLDQEC-----------LSLGKWHAAIGCAEI.... 306
5 -12.700[G] COG5026 Hexokinase  ali follow..  20  68.............................PMVPTWIIGTPDGNEHGSYLALDLGGTNLRVCAVEVQGNLPQELKVGTREALFDYIADCIKKFVEEVHPGKSQNLEIGFTFSYPCVQNDASLKGFDIDGVEGESVGPLLSAALKRVNAILSD----TTGTLVASNYASPGTEIGVIFGTGCNACYIEKFSEIDMNMIINCEWCHVVLPRTKYDVAIDEESPR----GLQTYEKMIAGCYLGDILRRILLDLYEQGALFNGQDVTKRACELIGTRSARLSACGVCALVRKMNKPSMIVGGSVYNLYPRFKDRLAQAFKDILGEEIGSKVVTIPAEDGSGV-GAALV.... 463
6 -11.700[C] COG3426 Butyrate kinase  ali follow..  16  1...........................................MSYDVLTINPGSTSTKLAVYHGDKVLFEEADFNNVQEQFDFRWQVLRRVIDAFGYDVNKLDAV-VGRGGLLRPVAGGTYMVTEKMLAGAMLAKKLADKLGIPSFIVDPVVVDEMQPVARGSEYEKMNFVIAHLGGGISVAAHRQGKAVDVNNALDGDGPFSPLPMNDFLEA-------CFSGKWT-LHELIVGRGGMISYLGTN----SMLDVENKVQAGDEDAIKAFDAMAYQVSKEIGACSVVLKIDAIILTGGLARSELFTSKIIEQTN................................. 321
7 -10.900[C] COG2441 Predicted butyrate kinase  ali follow..  15  1.............................................MISAGIDPGTGSYDVVAIE-DGKVVFRKNIPT--EEVRASPDVIVEVIEESGAEV--AGLSGYGLPLLMTLNFDSERAIGLRNIIKAVKERNVNLYTVPAVIHLPTVPVLAVAKLSEEEELTKLNFILAEVGEGFNAFIAVNGRIVDGMGGTTSFPGYS---------------------SLGAMDA-----ELAYIIGEFPKKLIFSGGVKSFASEWKVNENEVTNILSEFVLKGIRAMEVSTDADFYMLSGRFAPDVL----------RKLRGEGKEVRLLGGFGRGKQSAQGAAII.... 291
8 -8.940[H] COG5146 Pantothenate kinase, acetyl-CoA regulated  ali follow..  13  15.ETISNVERQLSQPPSVWLNLTGARIIENEGQFDKDIALPNNKSHVTHIAVDIGGSLAKVMYYVCESSSPSSSSSSIETAKIEDCIQFMANLIDNHVKNCNKKKITLIATGG-----------------GAYKFYDRMSKQLDIKVIREDEMECLIMG-FQNHLNCYHYPHMLVNIGSGVSGGSSLGGGTLWGLLSLLTPANSLELSKGGDNTSVDMLVGDIYGKDIGYERFGLKSTTIASSFGKVFRERKPLEEF-----APQDISRSLLLAISNNIGQIAYLHAQKHNVQNIYFGGSFIRNHVQTMHTLTYAIQYWSNHTMNAYFL--RHEGYLGVFGAFMKYATS 392
9 -8.300[I] COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)  ali follow..  13  1..........................................MTQIYKTGIDVGSTTVKLVVFDENFKLIFSRYERHFSDVKAATIKVFKDFIEEYGDLNLELAITGSG-----------------------------GMGLAEVIDVPFVQEVIASSITIEKFIPQTDVMIEL------GG----DAKMTFFDNGT----------------QELRMNGTCAGGTGAFIDQMAALLKVDANGVNELAKNYEKTDVQPLLNEGVRREDIAASIFQAVVNQTIAGLASGIKGNVAFLGGPLFFMSELRKRFIETLD------LKEENIIFPENPQLFVAMGAALYEETS 261
10 -7.500[G] KOG2531 Sugar (pentulose and hexulose) kinases  ali follow..  13  1.....................................MGPPKQLKRTFLGFDLSTQKLKAVLLGSSLEVVAAAEVKFDTDQPVMWVKAMDIVLDRLVMQQADLSTVAISGSG---QQHGSLSKHGINTLQNLDSEKFLHAQIDNRTPIWMDATCLEMEMAV-GGKLNMVELTGSKCYERFTGPQIR--KIYQQRCHAYEEANRISLVSSFISSL--------FLGSVAPIDF-GSGMNLLDIRKKNWSKECDLDKRLDIPVSPNSILGNVSPYFVERFS---------FSPDCKVAASTGDNPSALSG----------------MLVGSSWLTISMGTSDTLMMSLKE 313

FFAS is supported by the NIH grant R01-GM087218-01
1 2 0 3 2 5   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster

Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Jaroszewski L, Li W, Godzik A. In search for more accurate alignments in the twilight zone. Protein Sci. 2002 Jul;11(7):1702-13.