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Query: [A] KOG4676 Splicing factor, arginine/serine-rich, from COG0516

Results of FFAS03 search in COG0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSNTTVVPSTAGPGPSGGPGGGGGGGGGGGGTEVIQVTNVSPSASSEQMRTLFGFLGKIDELRLFPPDDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSLLAPANAVAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDTSSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEEDMDMSDLast
1 -64.700[A] KOG4676 Splicing factor, arginine/serine-rich  ali  100  1MSNTTVVPSTAGPGPSGGPGGGGGGGGGGGGTEVIQVTNVSPSASSEQMRTLFGFLGKIDELRLFPPDDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSLLAPANAVAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDTSSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEEDMDMSD 484
2 -27.400[A] KOG4849 mRNA cleavage factor I subunit/CPSF subunit  ali follow..  12  94.................................QLYVGNLTWWTTDQDIANSLRDIGDLQEVKFF--ENRANGQSKGFSVISLGSESSLRAVLDLPKKEMHGQAPVVTYPSKQALTQFESLQKTRPVPPPQQNGPPRGPAPQQGMNMTPQHGPPPQFAQHGPRGPWPPPQGKPPGPFPDPQQMGPQLTEVEFEEVMSRNRTVSSSAIARAVSDAAAGEYSSAIETLVTAISLIKQSKVAHDERCKILISSLQDTLHGIEAKSYNRRERSRSRERSHRSRQRRERSTSRYRERSRERERDRDRERERDGGRSVRPRKSPEPVVAEAAEAPSSKRYYEDRERYRSSDRER---RDRDRDRDRERERDRDRHFTNDGRGLPLDPSNFTSQNPGNIKTGRPKSAAVAGGSMEKPRGQSAWDIIDTDAHWIIKQQTTSIPAPPSSQQN......................................... 696
3 -22.200[A] KOG0113 U1 small nuclear ribonucleoprotein (RRM superfamily)  ali follow..  12  102................................RTLFIARINYDTSESKLRREFEFYGPIKKIVLIHDQES---KPKGYAFIEYEHERDMHAAY-ADGKKIDSKRVLVDVERARTVK--------------------------------------------RRLGGGLGGTRRGGNDVNIKHSGREDNERERERYRLEREREDREGPGRGGGSNGLDARPGRGFGAERRRSRSRERRDRERDRGRGAVASNGRSRSRSRERRKRRAGSRERYDEFDRRDRRDRERERDRDREREKKKKRSKSRERESSRERRERKRERRDRERGTGSGGDVKERKPDFRDMDVIKIKEEPVDDGYPTFDYQNATIKREIDDEDEEKYRPPPAHHNMFSVPPPPILGRGNASTNPNPDNGQQSSGDPSWWRQ................................................................ 448
4 -21.500[A] KOG4209 Splicing factor RNPS1, SR protein superfamily  ali follow..  17  72..........................KAEADAKSVYVGNVDYGATAEEIEQHFHGCGSVSRVTIQCDRFS---HPKGFAYVEFTEKEGMQNALAMTDSLLRGRQIKVDPKRT.................................................................................................................................................................................................................................................................................................................................................................................... 155
5 -21.000[A] KOG2217 U4/U6.U5 snRNP associated protein  ali follow..  10  2..................................................................................................................................................................................GSSSSGKKHKKDKKNRHRSRSSERPRRVTEDEDVTLDLTDDSSSRHRHHKHKKHKEHRHKHHKQKERERANEVISLEESDSDSSDCVEVPVQAQVQAQAKLRDARESSNRDKERDSGRDRELLRERERERDRERERDRDREKEREREREKERLRER-EEREREREKERIREREKERLRERERERERERVRELTAPPPPQISKHAEYESRREREIERERDARKRSGRERERERNRERSRSQSPASSSRKPATKEREPSSRSFSPIPENGAGDVLSITETNKLRAKLGLKPLEVDSGPSKAGPPPGS. 305
6 -20.600[A] KOG0108 mRNA cleavage and polyadenylation factor I complex, subunit RNA15  ali follow..  19  1..........................MSMTAGNVVFVGNIPYDVSEQQMTEIFNQVGPVKTFKLVLDPE---TGSGKYGFCEFFDSETTAMAVKLNNSELGPRKIRVEFPSNDPRRNQSYE........................................................................................................................................................................................................................................................................................................................................................................... 94
7 -20.000[R] KOG0118 FOG: RRM domain  ali follow..  16  141ENGGFRRKKSFGQGKRRMNARTSMAQREDVIRRTVYVSDLDQQVTEEQLAGLFVSCGQVVDCRICGDPN----SVLRFAFIEFTDEEGAMTALNLSGTMLGFYPVKVLPSKTAIAPVNPTFLPRTEDERE.................................................................................................................................................................................................................................................................................................................................................................. 266
8 -19.900[R] KOG0149 Predicted RNA-binding protein SEB4 (RRM superfamily)  ali follow..  18  1.........MAYQPVPGSGFHYLNSPFGDTTFTKVFVGGLAWETQSETLRQHFEQYGEILEAVVIADKN---TGRSKYGFVTFRDPEAARRACADPTPIIDGRRANCNLASLGRPRPPLPYAVI........................................................................................................................................................................................................................................................................................................................................................................ 113
9 -19.500[R] KOG0125 Ataxin 2-binding protein (RRM superfamily)  ali follow..  19  100....................QSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNER----GSKGFGFVTFENSADADRARKLHGTVVEGRKIEVNNATARVMTNKKMVTPYAN...................................................................................................................................................................................................................................................................................................................................................................... 202
10 -19.500[R] KOG0126 Predicted RNA-binding protein (RRM superfamily)  ali follow..  12  35...............................SAWIFLGGLPYELTEGDIICVFSQYGEIVNINLVRDKKT---KSKGFCFLCYEDQRSTILAVNFNGIKIKGRTIRVDHVSN-------------------------------------------------------------------------------------------RAPKDSEEIDDVTRQLQEKGCGARTPSPSLSESSEDEKPTKKHKKDKKEKKKKKKEKEKADREVQAEQPSSSSPRRKTVKEKDDTGPKKHSSKNSERAQKSEPREGQKLPKSRTAYSGGAEDLERELKKEKPKHEHKSSSRREAREEKTRIRDRGRLQMHILAGIMGVLKGVVIEVEVGAEINPIGIKGPDAPGRGVLRIP................................................................................ 316
11 -19.100[A] KOG4207 Predicted splicing factor, SR protein superfamily  ali follow..  20  14................................ITLKVDNLTYRTSPDSLRRVFEKYGRVGDVYIPLEPHT---APRGFAFVRFHDRSDAQDAEAMDGAVLDERELRVRMARY------------------------------------------------------------------------------GRRDLPRSSQEEPRGRSWGGRYGRRSGSPRGRHRSQSRGPSYSRSRSRSHYGGSRYSLSIYRRSRYSRSPYRRSHYRGSRYGRSPYSRSYSRHHYSRSPYRESRYRRSPYIRSSRSRSPYRRSHSKSGSHSASPSTSKSSS......................................................................................................................................................... 233
12 -19.000[R] KOG4454 RNA binding protein (RRM superfamily)  ali follow..  11  2.....................EIKPTPSPPEERTIYVANFSEEVDEELLEELFIQAGPVVKVILRDVRD----SNAKFALVEFEDELSVLFAILMNGVRLFNQELQVKPRNGTNQEELYKRKKGEIEERVRSVAAPDRDGRRDSYRDDRNRNRNGNNRDSWQQQQPPRHHRQYDPLPPPPPPPLMGGSGGHWRSGGERGPPQYSTPQMLPHQHFVNQMMQQQINRSAPPYNGRHQNSTPHRHHDRHGYDRSSSRHHRNDDRRRSAHFLDIRKFQAPPTSWAFGNFQ...................................................................................................................................................................................................... 263
13 -18.200[R] KOG0114 Predicted RNA-binding protein (RRM superfamily)  ali follow..  25  14...............................NRLLYVRNLPYKITSDEMYDIFGKFGAIRQIRVGNTPE-----TRGTAFVVYEDIFDAKNACHLSGFNVCNRYLVVLYYQS.................................................................................................................................................................................................................................................................................................................................................................................... 90
14 -18.100[A] KOG0121 Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily)  ali follow..  20  17...................GSRSEQERSLRDSCTLYVGNLSFYTTEEQIHELFSRCGDVRVIVMGLDKYK---TPCGFCFVEYYVRSEAEAAMFVNGTRLDDRLIRVD........................................................................................................................................................................................................................................................................................................................................................................................ 104
15 -17.700[S] KOG4610 Uncharacterized conserved protein  ali follow..  11  310..........................................................................................................................................................................................................................................RLYVVNAEFWKNRRESRMAKSRQFQSRRKVQDADQNSIYMISNERGGDVKKKIKRAKDKDYAEQEAVYSKKKKDKKDKKKRKRKDTGYSTASSQNLYSTKASGTDKDTRRKDKKGKKSKRTCSSSPSDCDLAKKQKRKNADKNDKKKSRKIEAVVEESSSSSSSSSDSSNSTLPSYEVIDEKKARRRKHRGSSSDTSSGDSSSSSSSSSSSDSS.................................... 523
16 -17.100[R] KOG0226 RNA-binding proteins  ali follow..  13  204.................................RVFCGDLGNEVSDELLAKAFRKYPSFQKAKVVRESRT--NKSKGYGFVSFRDSEDYVRAMRMDGKYVGNRPIKLRKSAWKERNIDVIKQK......................................................................................................................................................................................................................................................................................................................................................................... 292
17 -17.100[A] KOG0107 Alternative splicing factor SRp20/9G8 (RRM superfamily)  ali follow..  15  3.................................RVYVGNLDPRVTERELEDEFRSFGVIRSVWVA-------RRPPGYAFLDFEDSRDARDAIRVDGKNGWRVEQSHNRGGG.................................................................................................................................................................................................................................................................................................................................................................................... 75
18 -16.500[Z] KOG3809 Microtubule-binding protein MIP-T3  ali follow..  12  91.........................................................................................................................................................................................................KPARIVAGHEPERTNELLQIIGKCCLNKLSSDDAVRRVLAGEKGEVKGRASLTSRSQELDNKNVREEESRVHKNTEDRGDAEIKERSTSRDRKQKEELKEDRKPREKDKDKEKAKENGGNRHREGERERAKARARPDNERQKDRGNRERDRDSERKKETERKSEGGKEKERLRDRDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHDKPEKKSASSGEMSKKLSDGTFKDSKAETETEISTRASKSLTTKTSKRRSKNSVEGRKEDNISAKSLDSIVSGI 373
19 -16.300[R] KOG0130 RNA-binding protein RBM8/Tsunagi (RRM superfamily)  ali follow..  16  74.................................ILFVTSIHEEAQEDEIQEKFCDYGEIKNIHLNLDRRT----SKGYALVEYETHKQALAAKALNGAEIMGQTIQVDWCFVKGPKRVKKS........................................................................................................................................................................................................................................................................................................................................................................... 160
20 -15.800[R] KOG2295 C2H2 Zn-finger protein  ali follow..  10  245...................................................................................................................................................................................................................................DSSQADALIRVLDTCVIKLEGGTDEDLKVLDEKPKDPVVYERKAEQMQSVKEVEKTINSPKEEMSEADPVSTQRKPVRPVNSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGKDKVVETETIDLD 501
21 -15.700[A] KOG4206 Spliceosomal protein snRNP-U1A/U2B  ali follow..  17  9...............................NQSIYIQNLNERIKKEELKRLFSQFGRILDVVALKTPK-----LRGQAWVTFSEVTAAGHAVQMQNFPFYDKPMRLQYAKA.................................................................................................................................................................................................................................................................................................................................................................................... 89
22 -15.700[A] KOG0105 Alternative splicing factor ASF/SF2 (RRM superfamily)  ali follow..  25  2....................SGWADERGGEGDGRIYVGNLPTDVREKDLEDLFYKYGRIREIELKNRHG-----LVPFAFVRFEDPRDAEDAIYRNGYDYGQCRLRVEFPRT.................................................................................................................................................................................................................................................................................................................................................................................... 89
23 -15.600[A] KOG4212 RNA-binding protein hnRNP-M  ali follow..  16  204................................STVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGK---SRGIGTVTFEQSIEAVQAIMFNGQLLFDRPMHVKMDERALPKGD.............................................................................................................................................................................................................................................................................................................................................................................. 287
24 -15.000[R] KOG4208 Nucleolar RNA-binding protein NIFK  ali follow..  15  2.................................AAFSRSAGPILSDAELQKEVAQCDTVTRFRLSRKKRT---NSKGYAFVEFESEDVAKIVTTMNSYLFGERLLECHFMPPEKKMES.............................................................................................................................................................................................................................................................................................................................................................................. 90
25 -14.900[A] KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily)  ali follow..  19  2................................VRVYIGRLPNRASDRDVEHFFRGYGKLSDVIM----------KNGFGFVDFQDQRDADDAVHLNGKELCGERVILEFPRR.................................................................................................................................................................................................................................................................................................................................................................................... 72
26 -14.700[R] KOG2135 Proteins containing the RNA recognition motif  ali follow..  10  362............................NRDNCTLQVAKIPEMNTIAKLNEHFATFGTVDNIQVRYNGE------IDSALVTYASKFDAGKAYKSPTPVLNNRFIKVFWHNPGGEGSENATGKPSSPTSPPKPVEKPKIATVQESKFVSVAAQNYRKQIQDAKERLTKEKSILSTLVQAQNQHNIILDKWMVKQKELLIKARTSTDETDKKNATKLVKHLHKKIKACKEEVDGILLKISEKSMVVDEIAAQIEELKNPQKSDDSTRKRKAGSDGDEPQSKM........................................................................................................................................................................................................... 609
27 -14.300[A] KOG0128 RNA-binding protein SART3 (RRM superfamily)  ali follow..  14  593................................RTIFVSNLDFTTTEDEIRQAIEGVASIRFARKANSDL----VHRGFAYVVMENDQKAQQALLKDRVPVKGRPMFISANDPEKRVGFKFSTTLEKSK.................................................................................................................................................................................................................................................................................................................................................................... 684
28 -13.900[AJ] KOG0148 Apoptosis-promoting RNA-binding protein TIA-1/TIAR (RRM superfamily)  ali follow..  15  3............................DEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTA----GNDPYCFVEFHEHRHAAAALAMNGRKIMGKEVKVNWATTPSSQKKDTS........................................................................................................................................................................................................................................................................................................................................................................... 92
29 -13.900[J] KOG0122 Translation initiation factor 3, subunit g (eIF-3g)  ali follow..  22  214.................................SVRVTNLSEDTREPDLMELFHPFGAVTRVYVAIDQKT---VSRGFGFVNFVSREDAQRAIKLNGYGYDNLILRVEWAT..................................................................................................................................................................................................................................................................................................................................................................................... 290
30 -13.800[A] KOG0144 RNA-binding protein CUGBP1/BRUNO (RRM superfamily)  ali follow..  15  399..................................LFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQT--NLSKCFGFVSYDNPVSAQAAISMNGFQIGMKRLKVQLKRS.................................................................................................................................................................................................................................................................................................................................................................................... 475
31 -13.700[A] KOG0120 Splicing factor U2AF, large subunit (RRM superfamily)  ali follow..  11  86.........................STITRQARRLYVGNIPFGVTEEEMMEFFNQQMHLVGLAQAAGSACQINLDKNFAFLEFRSIDETTQAMAFDGINLKGQSLKIRRPHDYQPMPGITD........................................................................................................................................................................................................................................................................................................................................................................... 184
32 -13.700[A] KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily)  ali follow..  18  228..................................IYVASVHQDLSDDDIKSVFEAFGKIKSCTLARDPTT---KHKGYGFIEYEKAQSSQDAVSMNLFDLGGQYLRVGKAVT.................................................................................................................................................................................................................................................................................................................................................................................... 304
33 -13.600[R] KOG2888 Putative RNA binding protein  ali follow..  211.............................................................................................................................................................................................................................................................EQYCREQGVTVHQLSTGRSTAGTGGGPGAAGQDADYQDYPEGGVERGSGGRGGGQAGSRSNAYPQPNNYRNDYDERDYYAAASGSSYGRGRGGYEDYPPAPLPPQMPYGERERERDRDRDKNKDYDRHRSKHKKKHNHRQSSRSRSRSRSRSRHRSERHERKRDGGGYERSSKSRHNEHYEERERRHR........................................... 398
34 -13.400[A] KOG2253 U1 snRNP complex, subunit SNU71 and related PWI-motif proteins  ali follow..  14  60..........................................................................................................................................................................................................NTNEIAIDAAAVAQGAEKELHDDREAKNRPEASKRSRRSRSSSNSSSESDSSSSRSSSYSSRSRSRTPQRSRTSKRRRSNSHAEDSDDAREKRAFKQMMLDKKQAYLARLKRWESRERQMSKRYEREERKEKDRKKTLQKEGKRLKLFLEDYDDEKDDPKYYTSSQFFQRKRDYEREREADQKDRMQEQQEIEELKRQIMEEAANDESINIEEEARKRHKLKEEEAMRKMRADSGSPNPHQPLGQSANGEKSSSEEESDSEKTDVKKEIKDEIKEEPIDVD. 341
35 -13.400[K] KOG4661 Hsp27-ERE-TATA-binding protein/Scaffold attachment factor (SAF-B)  ali follow..  11  406................................RNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARS--PGARCYGFVTMSTAEEATKCIHLHKTELHGKMISVEKAKN----------------------------------------------------------EPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAGLDERYHSDFNRQERFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQHYPERHGGPERHGRD..... 793
36 -13.400[K] KOG3794 CBF1-interacting corepressor CIR and related proteins  ali follow..  10  337......................................................................................................................................................................................KRHKKHSSRTVEETDESSTGSEDSREKRGSKKRKKLKKKSKKQYDSDSLSFEGSGSDSYRLSRRRHTKHVDPSASLKSEVYHQGNSHREKHYYDEKHQKRKEIVDRPSASSDDSDYYRSNSSRKKRSEDDYKSHHRERKQVHSNDPVSEKSQKQHYSESGKIQRVEKEHRYDERRHRYVDMESENRNRSEKKPRYDDRDSEKHHRSVKGKEKHVYEASDDPEEFSDRYRSTKKTESDSESNRRSRKKKHELSSEEEEGESRVIGEQVRKSMSLIHRRLYRISGLSSVNAWNLQIREAVNRND 638
37 -13.200[R] KOG1457 RNA binding protein (contains RRM repeats)  ali follow..  14  77................TVSVLFVHELKTRPGVRTLFVSGLPVDIKPRELYLLFRPFKGYEGSLIK------LTARQPVGFVIFDSRAGAEAAKALNGIRF-PQTLRLEFAKA.................................................................................................................................................................................................................................................................................................................................................................................... 170
38 -13.200[K] KOG0147 Transcriptional coactivator CAPER (RRM superfamily)  ali follow..  15  140......................DNLSPEERDARTVFCMQLAARIRPRDLEDFFSAVGKVRDVRIISDRNS----SKGIAYVEFCEIQSVPLAIGLTGQRLLGVPIIVQASQA.................................................................................................................................................................................................................................................................................................................................................................................... 227
39 -13.200[TR] KOG4019 Calcineurin-mediated signaling pathway inhibitor DSCR1  ali follow..  14  2.......................EEVDLQDLPSATIACHFVDGLCRAKFESLFRTYDKDITFQYFK--------SFKRVRINFSNPFSAADARQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDK..................................................................................................................................................................................................................................................................................................................................................................... 103
40 -13.200[J] KOG2147 Nucleolar protein involved in 40S ribosome biogenesis  ali follow..  68..................................................................................................................................................................................DKRLGEKDGKSEEEKGAMRFTEERVKNYKRASKFNLTDDGDEEEEVLTHKGKALSDIEKYDKSMISDSDDDEEPGNLGSNMVKVAHFGGGEKTAEEHVREKISREDMISNLIAKTKLARHEKQQQKDELELMTESLDSKYQALMGKMKASFRPTGRQPLEKDDYDKLTITLKTEADARATPADRKLSEEEEALKEKERLETLEAAPDADVDIDAGSKADARKVQAKNSRFEVKFDDEGGLIDEDTVEKSRILKKNLDGSDESDDDEDLEDEEEDLDDLLEDEDELEEDSDDEEAQEAQKVVKKAKK 373
41 -13.000[K] KOG4210 Nuclear localization sequence binding protein  ali follow..  17  238...............................SRILFVGNLSFDVTDDLLRKHFQHCGDIVKIRMATFEDS----CKGFAFIDFKNEEGSTNELDKSCRKIAGRPLRMEYGED.................................................................................................................................................................................................................................................................................................................................................................................... 317
42 -12.900[A] KOG0145 RNA-binding protein ELAV/HU (RRM superfamily)  ali follow..  22  298.................................CIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNT--NKCKGFGFVTMTNYDEAAMAISLNGYRLGDRVLQVSFKTNKAHKS............................................................................................................................................................................................................................................................................................................................................................................... 380
43 -12.900[R] KOG0431 Auxilin-like protein and related proteins containing DnaJ domain  ali follow..  465....................................................................................................................................................................................................DKAEAKFRHAKERREKENLKASRSREGDHTENYDSRERELREKQVRLDRERAEREAEMEKAQEREKEEREREQKRIERERERLVARQAVERATREARERAATEAHAKVQRAAVGKATDARERAERAAVQRAHAEARERAAAGARDKAAKAAAEAREKAEKAAAEAKERANAEAREKETRVRAERAAVERAAAEARGRAAAQAKAKQQQENTNDLDSFFSSISRPNSAPRQRTNPLDPFQDSWNKGGSFESSRESLRVPPGQPENLRKTSSVTNIVDDLSSIFGGSAIS 752
44 -12.800[A] KOG0131 Splicing factor 3b, subunit 4  ali follow..  14  26.................................TVYVGGLDAQLSEELLWELFVQAGPVVNVYVPKDRVT---LHQNYGFIEYRSEEDADYAIVLNMIKLHGKPIRVNKASQ.................................................................................................................................................................................................................................................................................................................................................................................... 103
45 -12.800[R] COG0724 RNA-binding proteins (RRM domain)  ali follow..  16  166.......PPSRRAGARDPSSDAYRDSRERDDMCTLKIMQVNENADENSLRELLFPFAPIPRVSVVRNKE---TGKSRLAFVTFSSEEVAEQALFLDGRGYMNLILRVEWSK..................................................................................................................................................................................................................................................................................................................................................................................... 269
46 -12.600[A] KOG0146 RNA-binding protein ETR-3 (RRM superfamily)  ali follow..  18  39.................SPGNPSTIPMKDHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFT--GMHKGCAFLTYCERESALKAQALHEQKTLNRPIQVKPADS.................................................................................................................................................................................................................................................................................................................................................................................... 135
47 -12.500[A] KOG0533 RRM motif-containing protein  ali follow..  12  76..................................VNISNLAPTVISSDLEELFGDYR-LSSVSVNFNEH----DSLGTGDISLTKRDAERLVQKFSGVALDGKIMKFA........................................................................................................................................................................................................................................................................................................................................................................................ 145
48 -12.400[R] KOG0153 Predicted RNA-binding protein (RRM superfamily)  ali follow..  15  225...........................EDRNITTLYVGNLPEEITEPELRDQFYQFGEIRSIAL--------VPRQQCAFVQYTKRNAAELAATFNKLVIQGRKVSIKWAHSQAKQGTAAKTD......................................................................................................................................................................................................................................................................................................................................................................... 314
49 -12.200[A] KOG1190 Polypyrimidine tract-binding protein  ali follow..  22  472...............................SATLHLSNIPPSVSEEDLKVLFSSNGGVVKGFKFFQKD------RKMALIQMGSVEEAVQALDLHNHDL-NHHLRVSFSKS.................................................................................................................................................................................................................................................................................................................................................................................... 548
50 -12.200[D] KOG2186 Cell growth-regulating nucleolar protein  ali follow..  18  404............................DIAQRNIFVRGFGWDTTQENLKTAFESYGEIEECSVVMDKD---TGRGKYGFVMFKTRKGAREALKRPEKRMYNRIVVCNLA...................................................................................................................................................................................................................................................................................................................................................................................... 483
51 -12.000[R] KOG0110 RNA-binding protein (RRM superfamily)  ali follow..  26  4..................................IIVKQLPKHITEDKLRQIFGAQGTITDLQLKYTPDGK---FRQFCFVGYSTEEEAQSAIHFDNTCIQTSRVRVESCAA.................................................................................................................................................................................................................................................................................................................................................................................... 79
52 -11.800[J] KOG0899 Mitochondrial/chloroplast ribosomal protein S19  ali follow..  17  61..............................MSTKLYIGGLSPGTDEHSLKDAFSSFNGVTEARVMTNKVT----SRGYGFVNFISEDSANSAIAMNGQELNGFNISVNVAKD.................................................................................................................................................................................................................................................................................................................................................................................... 141
53 -11.400[S] KOG4843 Uncharacterized conserved protein  ali follow..  260...........................................................................................................................................................................................RENQNYNEQKGEIKMEKEGHAHLAWKEQKDYHRGKRVAEGSTANVDPWVVSRGNPQGPTEVGPKDLSAPVEGSHLEGRETVGENKVDAKNEDRFKEKDKKRKELKHREWGDRDKDRNDRRVSVLVGSVMSEPKEIGREERESDRWERERMEQKDRERNKEKDKDHIKREPRTGAEKEISQNEKELGEASAKPSEQEYVAPEQKKQNEPDNCEKDERETKEKRRERDGDSEAERAEKRSRISEKESEDGCLEGEGATEREKDAFNYGVQQRKRALRPRGSPQTTNRDNVRSRSQDNEG 556
54 -11.400[A] KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins  ali follow..  16  12.................................VVKVRGLPWSCSADEVQRFFS-QNGAQGIRFIYTRE----RPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN.................................................................................................................................................................................................................................................................................................................................................................................... 90
55 -11.300[S] KOG3869 Uncharacterized conserved protein  ali follow..  11  186.........................................................................................................................................................................................................KTEQEQKAAEGKKKNKKNKKSKKSKKKKKNRRSSNEESSDSESNDSDDDLDRKLARQVSKLKGDQGDLKLDKLLDAKYRTISNQLDMATKKKKSKKSKKKKSSDSSDESSDEEEEPRRKHKRSHSSEDRNQRERRRSRSPRDRKKRQSRSPEQRQRQRSPEERRERRRSRSRSPLARRQRRTRSPEDRKARRQSKDTSKQREKRRSRTPEERSRSKRSRSRSSKGDDKRRIAERPPPSRPTGKPKLSEADREARLREMMDNATWREADRSQVVRKHREAYARE 468
56 -11.100[Z] KOG3756 Pinin (desmosome-associated protein)  ali follow..  445..............................................................................................................................................................................................................GKENVSALDMEKESEEKEEKESEPQPEPVAQPQPQSQPQLQLQSQSQPVLQSQPPSQPEDLSLAVLQPTPQVTQEQGHLLPERKDFPVESVKLTEVPVEPVLTVHPESKSKTKTRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSTSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSRDTKGSKDKNSRSDRKRSISESSRSGKRSSRSERDRKSDRKDKRR..... 717
57 -11.000[A] KOG2412 Nuclear-export-signal (NES)-containing protein/polyadenylated-RNA export factor  ali follow..  6.................................................................................................................................................................................................................DEVFNSDTDSPEFEETCSTTSSTSSQCPTPEPSPAIKLPSFTKVGTKKLVNESVVILDPALENALRDLNLQSKLIPINEPIVAASSIIVPHSTNMPLPRASHSSLLDNAKNSNATAPLLEAIEESFQRKMQNLVLANQKEIQSIRENKRRVEEQRKRKEEEERKRKEAEEKAKREQELLRQKKDEEERKRKEAEAKLAQQKQEEERKKIEEQNEKERQLKKEHEAKLLQQKDKLGKAVTNFDKISKMFWHYKDKIAQIKQDIVLPIKKADVNVRN 280
58 -10.800[R] KOG4733 FOG: RRM domain  ali follow..  112.SPAAAQKAVSALKASGVQAQMAKQQEQDPTN--LYISNLPLSMDEQELENMLKPFGQVISTRILRDSS----TSRGVGFARMESTEKCEAVIHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQ...................................................................................................................................................................................................................................................................................................................................................................... 232
59 -10.800[R] KOG2140 Uncharacterized conserved protein  ali follow..  15  640.......................................................................................................................................................................................................................TDELREHLKNTPKVIVAQKPDVEQNKSSPSSSSSASSSSESDSSDSDSDSSDSSSESSSEESDSSSISSHSSASANDVRKKGHGKTRSKEVDKLIRNQQTNDRKQKERRQEHGHQETRTERERRSEKHRDQNSSGSNWRDPITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKKRGERRNSFSENEKHTHRIKDSENFRRKDRSKSKEMNRKHSGSRSDEDRYQNGAERRWEKSSRYSEQSRESKKNQDRRREKSPAKQ. 907
60 -10.600[S] KOG2889 Predicted PRP38-like splicing factor  ali follow..  10  171...........................................................................................................................................................................................................................................................................................LEEVDMLPSYKSLLDGDLVAMSDSDSEEEEVTKKEKPRLTSRRRSRSRDRERDVGDRREVREREKLKERRERGDDEPGPSSSGSGRRDDRDDRRRDRDRSRDRDRRDRRDDDRRDKKKESRRGGADNDEEREIAEANALRAKLGLAPLER................................................... 320
61 -10.600[A] KOG0115 RNA-binding protein p54nrb (RRM superfamily)  ali follow..  18  118..................................LFVGNLPNEVKETELKELFSPHGDIAECYL---------SGKGFAFLRLDTRAHAESAKAIDGRIIHGRQVRVRFAVH.................................................................................................................................................................................................................................................................................................................................................................................... 187
62 -10.300[AR] KOG0109 RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains  ali follow..  18  381..................................LHVGNISPTCTNQELQAKFEKYGPVIECDIV----------KDYVLIHFIHMECCPQAR....................................................................................................................................................................................................................................................................................................................................................................................................... 429
63 -10.200[O] KOG0111 Cyclophilin-type peptidyl-prolyl cis-trans isomerase  ali follow..  15  3.............................TTKRVLYVGGLAEEVDDKVLHAAFIPFGDITDIQI----DYETEKHRGFAFVEFELAEDAAAAINMNESELFGRTIRVNLAKPMRIKEGSSRP.......................................................................................................................................................................................................................................................................................................................................................................... 94
64 -10.000[R] KOG3263 Nucleic acid binding protein  ali follow..  12  2..............................................................................................................................................................................................................................................................SSSRSGEHRRNYAQGRNYESSRSRGDQRDRDYREYRRNYRDERSSRRYEDSQRRDYSPARRRDRY-ERHRESVREESPRRPVEHERNWQPELKHGRERFRERDYEGRRDRKERRDGVSPFSPEGEGLERKREHEKLQAPSPKEEEERPVDQGDKMDGVKEDKDGSLEVGKSHDAMTRTKSAEEEIVEQEDEATAEMKRIMGFSGFDTTTGKKHGDVGQVYKQKKTKYRQ. 229
65 -9.990[S] KOG4051 Uncharacterized conserved protein  ali follow..  138....................................................................................................................................................................................................ENARKSPNSNEEYPRVEDMNEKDSTIPKESPSTDLKNDNNKQEKNATIKVKELPEYHTEENDSPIDVQKEPIKEVQSDEKELQREHMSEEEQKMKSTNKTAAPVRKSQRLKRSKEVKFEDEEKEEIEEDNTKDEEQKEKKEEIQEPKITHNEEVDKEKNENEEGDDEREKSTSYENTNGSESEGVDEGVDEELGYESEREAEGKGKQIESEGGNLKKKTENKKGDDQQDDTKKDSKDKNEPLAKRTRHSSSTGNTSNETSPKRKRRKAGSRKNSPPATRVSSRLRNKK 425
66 -9.980[D] KOG4660 Protein Mei2, essential for commitment to meiosis, and related proteins  ali follow..  19  260......................ENPSEKDMNQGTLVIFNVDTTVSNDELLQLFGAYGEIREIRETPN-------RRFHRFIEYYDVRDAETALALNRSEIGGKCIKLELSR..................................................................................................................................................................................................................................................................................................................................................................................... 342
67 -9.920[M] COG3064 Membrane protein involved in colicin uptake  ali follow..  32.....................................................................................................................................................................................................................SSFDEHIEASAGGGGGSAIDAVMVDPGAVVQQYNRQQDQQASARRAEEERKKLQQQQAEELQQKQAAEQERLKQLEKERLAAQEQQKQAEEAAKLAQQQQQQAEEAAKAAADAKKKAEAEAAKAAADAKKKAEAEAVKAAADAKKKAEAEAAKAAADAKKKAEAEAAKAAAEAKKKAEAEAAKAAAEAKKKADAEAAKAAAEAKKKADAAAAKAAAEAKKKADAAAAKAAADAKKKAAAEKAAAAEGVDDLLGDLSSGKNAPKTGGGAKGN 302
68 -9.920[K] KOG1548 Transcription elongation factor TAT-SF1  ali follow..  11  110................................KAVYIQGLPLDVTVDEIEEVFKKCGVIAKIKIYRTED----TPKGDALIVFFRSESVELAEQFDDTEFRYGSGQKMRVQ..................................................................................................................................................................................................................................................................................................................................................................................... 194
69 -9.710[R] KOG0151 Predicted splicing regulator, contains RRM, SWAP and RPR domains  ali follow..  18  167............................DPQTTNLYVVNLSSKVDENFLLRTFGRFGPIASVKIMWPRTEEEKRRERCGFVAFMNRADGEAAKKMQGIIVYEYELKI......................................................................................................................................................................................................................................................................................................................................................................................... 247
70 -9.710[T] KOG0116 RasGAP SH3 binding protein rasputin, contains NTF2 and RRM domains  ali follow..  17  277................................YTIFVANLLMDATPEQLNETFKGFGAITKDGIQVRSY---LKGNCFGFVTFASAEAVKLVLQ-SAIRIGNRRVSIE........................................................................................................................................................................................................................................................................................................................................................................................ 353
71 -9.490[O] KOG0314 Predicted E3 ubiquitin ligase  ali follow..  15  508.................................................................................................................................................................................................................................................REEFEAKKTEMKRKRENEIRRSEGGNVVRDSEKSRIMNNSAVTSSPVKPKSRQGPPPPISSDYDRRRRSDRSSPERQSSRRFTSPPRSSSRKSERDRHHDLDSEHDRRRDRPRETDRKHRKRSEKSSSDPTVEIDDNNKSNVFTRISFPEESSGKQRKTSKSSPAPPESSVAPVSSGRRHHSRREREMVEYDSSDDEDRHFKRKPSRYKRSPSVAPSDAGDEHFRHSKRSKGERARA...... 744
72 -9.480[A] KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily)  ali follow..  22  58..................................IFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFN---GNNRGYAFVTFSNKVEAKNAIKLNNYEI-GRLLGVCASVD.................................................................................................................................................................................................................................................................................................................................................................................... 134
73 -9.360[A] KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1  ali follow..  16  19......SPPVDGHEEARLNADSDDGSHGSQDPGKMFIGGLSWQTTAENLRDYFGRFGEVNECMVMRDPA---TKRARFGFITFVDPSSVDKVLNNREHELDGKKIDPKVA...................................................................................................................................................................................................................................................................................................................................................................................... 120
74 -9.280[S] COG4078 Predicted membrane protein  ali follow..  89VFNFTLFLSLLGISNMGLIGTTVEDEFAECAFNYGLMCLIASLPLFGGAALILASTGTLSVHELMKMPKGAGGWTLTYGKALLTAGVIGEAGVG---------PFYAVKVDSFRRIWGRYAFVIHLTTL................................................................................................................................................................................................................................................................................................................................................................... 209
75 -9.170[T] KOG1882 Transcriptional regulator SNIP1, contains FHA domain  ali follow..  2.......................................................................................................................................................................................................................................................................KAVKSERERGSRRRHRDGDVVLPAGVVVKQERLSPEVAPPAHRRPDHSGGSPSPPTSEPARSGHRGNRARGVSRSPPKKKNKASGRRSKSPRSKRNRSPHHSTVKVKQEREDHPRRGREDRQHREPSEQEHRRARNSDRDRHRGHSHQRRTSNERPGSGQGQGRDRDTQNLQAQEEEREFYNARRREHRQRNDVGGGGSESQELVPRPGGNNKEKEVPAKE 222

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.