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KOG4333
Query: [DK] KOG4333 Nuclear DEAF-1 related transcriptional regulator (suppressin) and related SAND domain proteins, from COG0312

Results of FFAS03 search in COG0312
Master-slave alignment does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGLFIDGHFYNRIYEAGSENNTAVVAVETHTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMATEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDAAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKSQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQDGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEEKVVAEMEEHQHQVHNVEIVVLEDLast
1 -192.000[DK] KOG4333 Nuclear DEAF-1 related transcriptional regulator (suppressin) and related SAND domain proteins  ali  100  1MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGLFIDGHFYNRIYEAGSENNTAVVAVETHTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMATEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDAAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKSQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQDGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEEKVVAEMEEHQHQVHNVEIVVLED 573
2 -12.600[K] KOG3915 Transcription regulator dachshund, contains SKI/SNO domain  ali follow..  1..................................................................................................................................................................................................................................................................................................................................................................................MAVPAALIPPTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSIGPPASSGPTLFRPEPIASAAAAAATVTSTGGGGGGGGSGGGGGSSGNGGGGGGGGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPSPVENTPQNNECKMVDLRGAKVLFLKH 221
3 -12.600[K] COG5641 GATA Zn-finger-containing transcription factor  ali follow..  128...............................................................................................VPVCKN------------------C--------TP--------------WRRD---HGAML-----------------C-NACKLHGKPRPISLKTDVIKSRNRKSNTNHAHNLDNFRNQTLIAELKGDCNIESSGRKANRVTSEDKKKKSSQLLMGTSSTAK------------------------ISKKPKTESKERSDSHLSATKLEVLMSGDCSRPNLKPKLPKQDTAIYQEKLLTFPSYTDVKEYSNSAHQSAFIKERSQFNAASFPLNASHSVTSKTGADSPQLPHLSMLLGSLSSTSISNNGSEIVSNCNNGIASTAATLAPTSSRTTDSNPSEVPNQIRSTMSSPDIISAKRNDPAPLSFHMASINDMLETRDRAISNVKTETTPPHFIPFLQSSKAPCISKANSQSISNSVSSSDV----SGRKFENHPAKDLGDQLSTKLHKEEEIIKLKT-----RINELELVINED 529
4 -12.600[U] KOG1091 Ypt/Rab-specific GTPase-activating protein GYP6  ali follow..  330.............................................................................................................................RWLR-REFLL---QDLLLVWRSSL----IDLNKIIQKAKLLQALVLDTDMLSALSINGVFDQSNFVPARTKSCSTSPRSPLIIAPESYWEKKWRVLHKAEEEENKICLEKQTPPTQKKKRWLNVTKLFRAVIDLSHHKLGIGERKANSSPVTQSLLEDSSEQLNVDCHVTVNKENIHPQETEENIMEFHSADEESIVSGSSPSEESSFVSLDPTSPVRCSTKIENDSVSSAGSNLLPDEDDKSIVSISEENSSVSSDPISPAIDSNYSGKYLDCCTGSENDKDQQTSVNSPLSVSPHRRNEYPVTQSDEDVSTDKSVGITKEYKLLHGIKRTLSSEETSHRKASDATKTNDVKIKKNQIGCYSESHPQALSSGDSSQNLRKTLKNLGQSMLKHIEAIELVFQQEPCLVPAGLIGNLAKTNLIEKGQVTATTA----KLSNL----LSE 839
5 -12.300[TZ] KOG3671 Actin regulatory protein (Wiskott-Aldrich syndrome protein)  ali follow..  286.......................................................................................................................................................................................................................................................................................................................DMDEATKNILKAAGLESNNLNEDDKKFVKKFIAKNYDKYVSVGSLDPSQISSPLPPPIQQHPQMNQSWNQTPVRQYKPSFPSSAPIGSGASSYSTPAAPPPPTRVESHGLAPARPPPPPPSSGTRGIAPSRPLPQAPNYGTPENRPHAVPPPPPPPPPQSFGMAPISSAAPPPPPPPPPMGLPAVGAGAPPPPPPPPPSGAGGPASVLAKLPPAQDGRSNLLAEIQAGKQLRSVQQTADSPKSAGGDARGDV-NYRIVNFQD 623
6 -12.300[S] KOG4502 Predicted membrane protein  ali follow..  11..................................................................................................................................................................................................................................................................LWSSIAGSLPLAPASPDFKADFSKLLKEAHQTDLMPVVEEDELQSLRHYTFHEQLHHLRQKTVGRNSATITEEMARIRNSIEDISEFSLDSNEVDEAINDITVPYGTKMKKSSKFAELSEIHNTDSSNKALPPFAFSEDQQESVDVVEKVEAVPPTTTTTKLTTLPSTTQSTTTRTTTQPSTIVSTRQKYVNVDGDIYVPSVSSTPIVDRTGTTTPVSIEISTTTLPPMTEIFTTKYSTLSTSYTHTPSPHIFSSSTVRLPIAIPIPTKLPEIMFTTPRPYRGPFITEFTIEPKRSEGR................ 320
7 -11.400[S] COG3976 Uncharacterized protein conserved in bacteria  ali follow..  5.......................................................................................................................................................................................................................................................................................................................................................................................LRGGPDGPPCEISTWKHNSMKQIALSLFVIAASGAYVWDQAGKNPANDMLEALPADAAEAPTVQPKEPASAAALPVLRTSPAPLDPRFRTRLPIARETTAGIAVPAERPNDPVKQTVVPVAPQPSPAPPAQPVTPAVTDPASSTPSFAVTPAIYIPVPQPRPAYPNAPVRVVRVGMKPAAHGYADGVYTGIQIALVQG 213
8 -11.000[Z] KOG4462 WASP-interacting protein VRP1/WIP, contains WH2 domain  ali follow..  10  109................................................................................................................................................................................................................................................................................................................................................................MPKLRHIGKSSASAAPPSAPAPPTPQSELRPPTSAPPRPSIPPPSPASAPPIPSKAPPIPSSLPPPAQPAAPVKSPPSAPSLPSAVPPMPPKVPPPPLSQAPVANTSSRPSSFAPPAGHAPNVTSESPKFPNRGPSIPSASVPPVPPSSYVLQQRPNRVDDHGRFHFKDDSYLPIPHPFLGVPKVYRGGSGTTVPLNLSS..................... 308
9 -10.900[R] COG5236 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  186.................................................................................................ICAT---------------HKHAFPCELEIFTQNQLRNHQTKGNSEGFKGHPMCAFCSGKRFYSDDELYIHNQHEKCHICCLDNKFVVFKDELELQAHILQEHGNILKGKPKFFQSELSTFISAPSRVIRERDDYDLPSISSLPGSSSGSRTDVRSASSPE-----ESRLRLAERAKYYLENSKEDFNKFSSYNEDYSKGRLSAEKL----------------LESYKLLFTKPNADVYLLIHNLAETFPKNSSKYNNLNAIYEQREQTLARQTSLPSSSDSSLSMSIGRGHWGGTNDGGSAGAALGVRNIKNLPTLKSPSASYDPFATTVKKNTLRPVQNIKRTTPQSVSYRTSTNTVAFSPTYLESKKGSSSTSLNNSKDKLKSLNLPQLPPPKP-----------------KVQIPGLNRPQIADPKQWGKKSSTQDTNVHDNLRELNTTSGGNKKKGKQKQL-HIGV..... 639
10 -10.900[R] KOG0231 Junctional membrane complex protein Junctophilin and related MORN repeat proteins  ali follow..  10  285...................................................................................................TETVGEWKNDKRSGFGVSQ---KYEGEWASNRRMTFPDGTKEEGKYKQNILVGGKRKNLIPLRASKIREKVDRAVEAAERAATIAKQKAEIAASRSHSRAKAEAALTAAQKAQEEARIARITAKEFSPSFQHRENGLEYQRPKRQTSCDDIEVLSTGTPLQQESPELYRKGTTPSDLTPDDSPLQSFPTSPAATPPPAPAARNKVAHFSRQVS--------VDEERGGDIQMLLEGRAGDCARSSWGEEQAGGSRGVRSGALRGGLLVDDFRTRGSGRKQPGNPKPRERRTESPPVFTWTSHHRASNHSPGGSRLLELQEEKLSNYRMEMKPLLRMETHPQKRRYSKGGACRGLGDDHRPEDRGFGVQRLRSKAQNKENFRPASSAEPAVQKLASLRLGGAEPRLLRWDLTFSPPQKSLPVALESDEENGDELKSSTGSAPILVVMV----------------LLNIGVAIL.. 742
11 -10.700[S] KOG4791 Uncharacterized conserved protein  ali follow..  411.................................................................................................................................................................................................AEEEHRQQEAERQKSKKDTTCIKLKTDSEIKKTVVLPPIVASKGQSEEPAGKTKSMQEVHMKTVE---KLEKALRVQQSSESSTSSPSQHEATPGARLLLRITKRTWRKEEKKLQEGNEVDFLSRVRMEATEASVETTGVDITKIQVKRCEIMRETRMQKQQEREKSVLTPLQGDVASCNTQVAEKPVLTAVPGITWHLTKQLPTKSSQLNVKWSAQTLEKRGEAKPTVNVKQSVVKVVSSPKLAPKRKAVEMHPAVTAAVKPLSSSSVLQEPPAKKAAVDAVVLLDSEDKSVTVPEAENPRDSLVLPPTQSSSDSSPPEVSGPSSSQMSMKTRRLSSASTGKPPLSVEDDFEKSGGKLEAEIDLDPGK--DEDDLPLE. 804
12 -10.400[K] KOG4477 RING1 interactor RYBP and related Zn-finger-containing proteins  ali follow..  11  184..........................................................................................................................................................................................................................................................................................................................................................KTTEESVPHIESNVNTELVKEENKKPTPEDSIGPVSSDSLTTNQGEDQSTAQTASTSAPSVPEPTPKISVAETMVVPKALPASIAIPSTSTASVSTHPTEKPKEDSILQHLPERIVKKLNQPSSLNYDLLKVHKRMTGIDPIVAESEAVLLPQDWNRQKVMKELTASFGGNQALSPTTSRQSSETDSSSSEGNRSFETPLNDASIFNSKSCQIPDMINR-KIFIVEE 425
13 -10.400[KB] KOG4161 Methyl-CpG binding transcription regulators  ali follow..  10  561....................................................................................................................................................................................................................................................................................................................KTYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAVKRTHPSSIDQVEAVPKNQIPNQQFFAKMHQQDLQQSRSFKRQSVSATATSSTPSDITPTKALLSPKMEPPSVSPTVESGIKQEDVSLDAGPTQSFNPSLSRSCKRARLSPSKRPSGSRKSNRQRSQRRPILSDNPAGHGLTEQDVEETRQSFNTPTPDTSKKRRSGAATTPISSIDSPAMGDSVSTPSSNDQTDINAALAPPPAETLSKAPQYIKENGEL--IRIVRMRQ 826
14 -10.100[K] KOG0323 TFIIF-interacting CTD phosphatases, including NLI-interacting factor  ali follow..  258...............................................................................................................................LRPEELRSYLTAKTRKRFEVYVRDYALEMWRLLDEAHL---------------------------------------------------SLKELRDRIVCVKPDAKKSLLSVFNGGICHPKMAMVIDDRMKVWEDKDQPRVH--------QAEACALVVPHLCVARNVACNVRGYFFKEFDESLMSSISLVYYEDDVENLPPSPDVSNYVVIEDPGFASNGNINAPPINEGMCGGEVERRLNQAAAADHSTLPATSNAEQKPETPKPQIAVIPNNASTATAAALLPSHKPSLLGAPRRDGFTFSDGGRPLMMRPGVDIRNQNFNQPPILAKIPPSSSMHSPGGWLVDDENRPSFPGRPSGLYPSQFPHGTPGSAPVGPFAHPSHLRSEEVAMDDDLKRQNPSRQTTEGGISQNHLVSNGREHHTDGGKSNGGQS---HLFVSALQE 664
15 -9.910[A] KOG2245 Poly(A) polymerase and related nucleotidyltransferases  ali follow..  498....................................................................................................................................................................................................................................................................................................................................AEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNVIPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKN---------SIRLTL... 734
16 -9.560[DZ] KOG3757 Microtubule assembly protein Doublecortin and related proteins, contain DCX domain  ali follow..  10  1..................................................................................................................................................................................................................................................................................................................................................................................MPQTSAWQLNDTTARPPPPPPPPGSEAGGSDGASMNGANTLPRVSKRVSAAGKTSNIPRFKRPHLPHSTRPLSAVLTSSSSPVVHRKISPSSSAPSTSSAHRRFSHLPQQHFHHHIHHNQTAVISEETLTTPRASTLNLNQTSVFPTAISQGSMPNSGTNTAEASMTSSVCAMETEGTNGDELAESRDMVSEYRNIQYALMED 244
17 -9.350[O] KOG0802 E3 ubiquitin ligase  ali follow..  12  366........................................................................................EPMAKAKRLHCNHL--------F-----HLGCL---------------------RSW--------------LDQGL----NEVYSC--TCRKP--------VGRTENEVNPRTVEVSSDEQLARQLERQNNPVHALATGLFPAEVPDSVENDTSRNLGLDPSWLQTWSSQGSDVAGPSTTSRTVGLGRVQMMMRHLASVGESYAQTALDDAAWSLWPMNPSQASTSSTTVPPGNGGRTGGLHLRTVSNTTNESLTNILAMAETVREVMPHVPDEIIFQVNFKCILDY...................................................................................................................................................................................................... 593
18 -9.190[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  5.................................................................................................SCGVEFTVFRRKRYYCAN--KRCSVFAQRPLSRTDLL----KLKPKDLIFYLQSKHISTEGCLEKEEL-----------------VGLVLTHVAQVDRSRGSNASSNSPGRGQANPIDSLKQSCQNFFSNLSDNISDSLASFDSKVTTKPPESRQPEVPTHIFEQPRVSTREIPTYASAVNGGPQHVHVQQQATTTNGGSQSSSSPSTSTQSSNNRDASSSSQAHVAHQEARNEEQEDAQSKSDCECSDEEIMATFSERVSISLKTDTSGRRVNAAAEPSPVDLANVDNGPAGNTAPSPGCSKPGSSSSKADASSQSSFEELGAIGGISDESKANTDTNSSHLDQWQVLEVNRIEAVEETPTTSAADEILEVTLRSRPAVEGDD............................................................................................ 379

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Zhang Y, Stec B, Godzik A. Between order and disorder in protein structures: analysis of "dual personality" fragments in proteins. Structure. 2007 Sep;15(9):1141-7.