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Query: [S] KOG2861 Uncharacterized conserved protein, from COG0516

Results of FFAS03 search in COG0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MMRSVDVYVKTLGPPVRSILYSIFTSQQKPSSLPSLPFHFSLRSSSNIPTRCFSNVVAKSNSPIYDFQGFRNLFTERAISSSTTTPVASAQPQQLQNQNQHPAEVDEEISMGLEDEAKLSIPVRAYFFSTSVDLRSLIEQNKQNFIPPTSRMTNYVVLKFGNHSDPTDTTRGRISGSESIYMVVFHYGSIVLFNVREHEVDEYLKVVERHASGLLPEMRKDEYEVRENPNLDTWMEVGRDFIRLQFLNTDGIRTIGCVLGQSIALDYYGRQVDGMVAEFTEINRQLEITGTFTMKRKKLFQLVGKANVILADVILKLGLFERSDIAWKDAKYGQIWEFLRDEFELTQSFANLDYKLKFVEHNVRFLQEILQNRKSATLEWLIIILISMEIAISFYNMSRASLLast
1 -116.000[S] KOG2861 Uncharacterized conserved protein  ali  100  1MMRSVDVYVKTLGPPVRSILYSIFTSQQKPSSLPSLPFHFSLRSSSNIPTRCFSNVVAKSNSPIYDFQGFRNLFTERAISSSTTTPVASAQPQQLQNQNQHPAEVDEEISMGLEDEAKLSIPVRAYFFSTSVDLRSLIEQNKQNFIPPTSRMTNYVVLKFGNHSDPTDTTRGRISGSESIYMVVFHYGSIVLFNVREHEVDEYLKVVERHASGLLPEMRKDEYEVRENPNLDTWMEVGRDFIRLQFLNTDGIRTIGCVLGQSIALDYYGRQVDGMVAEFTEINRQLEITGTFTMKRKKLFQLVGKANVILADVILKLGLFERSDIAWKDAKYGQIWEFLRDEFELTQSFANLDYKLKFVEHNVRFLQEILQNRKSATLEWLIIILISMEIAISFYNMSRASL 402
2 -95.300[S] COG1723 Uncharacterized conserved protein  ali follow..  15  6..DDQPERHALLHNDIQTSNNSRPSLVQKKYLPTPQDTRKSRASYTGSAINPTSKQSRTGSGAQRTSRTAQKLKLLPEEPFQRDSERLTDLKNQSQVNRIKDKPARRDAEKLGKAHRHLLPRSTAYCTASSYNMKELVRWLKDCRKLHHTHWRGDKRFEDEDVIRLDDEGGEIIVSDKHPDLFIFEYGVVVMWGFTEREEKAFLNDIEKFEKEKLAEEDIQVEEFNYYVTKSYQPRIYNDFITLRDGSYMVKLSISHAIAQSVKISLFEELVDNTIEDTQDIPQEIAYSGKVSMSKEDIMKSIGELFILRININLHGSVLDSPEIMWSEPQLEPIYQATRGYLEINQRVSLLNQRLEVISDLLQMLKEQLGHSHEEYLEFIVILLVGVEVLISVINIVVDML 426
3 -6.800[P] COG0598 Mg2+ and Co2+ transporters  ali follow..  13  25...........................................................................................................................................................................................EPVIWFDLFNPSSEETRLVEERLGIAIPTRDEMQEIELSDRLYQEDGAEFGATLVTVRHAEPKPFQVYANRIMKLVMLGLLEAMIDRTADALERAGNDVDQISREVFRKQSLIEQIGQLVSIGRLVAYHVAIEGSTPRKAAKESRQRIKLVQRDAASLGDHALFLSNKINFLLDATLGLINLEQNQIIKIFSVAAVVFLPPTLVASIYGMNFEVM 296
4 -6.480[NU] COG2064 Flp pilus assembly protein TadC  ali follow..  112.....................................................................................................................................................................................................................................................................FYITNVRRGKIDSSLPHAVNMMLGMAKGG---VPLISIFRFVGEISREFDKIVTLVEIFGYD----PSEKLKVFLENFINVYEGGGDVEYLRAKSEQLLTERETYYTLFFETLQVYAEIYLALFIVAPLFFLIVLVVFQMV 265
5 -6.190[R] COG4915 5-bromo-4-chloroindolyl phosphate hydrolysis protein  ali follow..  10  64....................................................................................................................................................................................................................................................................TKKEYKYIRTNLEEARVKIIRLQKIMTQNKALYSFQEKTLLLTKRIYGI---------VKEEPKRFYEAEDF--FFSHLDSLVELTEKYAFLEKQLSDTRTLLNDLSRVIEKDLFTLLN-----VNNLDFELEVAK...... 197
6 -6.030[U] KOG1691 emp24/gp25L/p24 family of membrane trafficking proteins  ali follow..  14.....................................................................................................................................................................................ALLSPRTLSMRYELKSSKTKCIGEEIH------------------------ENAMSIGKYFIVNPNEDNHPLPDSHKIIVKVMPPQGKNLHEADKVEAGQFSFTAYENGSYVACITAIDYKPETTLTIDFDWKTGVHSKEWTNVA-KKSQVDMMEYQVK---TLMDTVISIHEEMYYLREREEEMQE-LNRSTNSKMAWLSFGSLVVCLSVAGLQFW.... 201
7 -5.890[E] KOG3216 Diamine acetyltransferase  ali follow..  4.................................................................................................................................................................................................................................................VRIRSVIKEDLPTVYQFIKE---LAEFEKCEDQVEATIPNLEVAFFIDEVTPVAYGVFIEENDQPAGMAIYFLNFSTWTSRVGIY-----LEDLY------VRPQFRGKGYGSYL------LSYLARESLRIGGRRLDWVVL................... 126
8 -5.770[K] KOG0483 Transcription factor HEX, contains HOX and HALZ domains  ali follow..  16  71............................................................................................................................................................................................................................................................................EKKRRLGVEQVKALEKNFEIDNKLEPERKKLAQELG---------------LQPRQVIWKTKQLERDYGVLKSNFDLKRNRDSLQRDNDSLLGQIKELKAKLNVEGVKGIE....................... 177
9 -5.680[R] COG3179 Predicted chitinase  ali follow..  11  66..................................................................................................................................................................................................................................................ELKDAGITTRLRMAHFLAQTGGLRRIDENMNYSAQTLLRVPQAIANGARLNYRGSGFMQLTGRTNFRMRGRDIGLPLEDSPELYWKARNINAAADN-NDKKRVRILVN-FEQSTVFFSQAWSRVFK.................................. 243
10 -5.550[S] COG3274 Uncharacterized protein conserved in bacteria  ali follow..  9...............................................................................................................................................................................................................................................DNLAVACIMVVMIHSTTYYVTRGAQVGELNWDIANVLNSASRVPLFFMISGYLFFGEKSAQKHFMRIGL--------------CLLFYS------IALIYISTLT---------------IDGWASLRNILQKPVFYHL-WFFYAIIVVYLVSPLIKVKPV.. 139

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.