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Query: [A] KOG2548 SWAP mRNA splicing regulator, from COG0312

Results of FFAS03 search in COG0312
Master-slave alignment does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MWHEARKQERKIRGLIVDYRKRAERRQYFYDKIQADPTQFLQLHGRRSKIYLDPAVAAAGDGAAIMQGQQDNLIDRFDVRAHLDHIPPVNKTNAEGADGDSELTLEERQLNYERYRILAQNDFLNVSEDKFLHQLYLEEQFGANAQLEAERNLAKKKQKTGGATIGYSYEDTGDGATIGPQPFGAASSTVIGGAAAVAKGEKGDGSEESDSDIDMDVSIDIGKLDTSQAHELNACGRNYGMKSNDFFSHLTKDADEADALRIAREEEQEKMLLSGRKSRRERRAQKERRIANRPFSPPSYAAKEDKDKKGGGKGGEKEKEEDSESRSPSPAEAGPEKITYITSFGGEDEMQPHSKITISLTKPGLTLGESCINASSGAAIAAAAASSVSYAQKVKDNLDKLKVMNESSKRNRRRSRSHSRSRSRSATVSRSRSGSRRSGSRRRSRRSRSYHRRSRTRSRRRRRYYSRSRSRSRSRSRSLSRSRSRSRSRSRSGSWKRYKARSPSYKRSRKRYSYSSRSSSGSSYRRRSRSRSPSNRRSRVKKKTTPPPVATVGGYCLNTTTTTTTSTVTAVKMFQQQQQQPPAKATPPMISYPIPARMLNVNQALTATAPVAVQPQVVEPPPPPLKRYYGRKRGNDTSSSSSSGAENSEGSDNEEQQQPQLGKRAEDSDDMELDTASERSHALQPTMSSSSSTGNQTGKYSSATETGSGHPSSGGGGRPNLRERLKRKMQNLLNRQYKADKRAEIEKTERERLQQQEREDEMRELALKLRRRRRELRHKYGTPSSGKLSDSDAESVASESQLAKSSTRRSRSRSESRRRSPPPETQHSRRSSSRTERRRRTRTPSPKYNRRQRSRSRSGSRVERKRRSHSRRRSGSRDRRRSRSRRSQSRRRRQRDRSIERNREREQYRQQHQQQNERLRGRDRDREADYGHGGSGSSNRGRVVISAPPKLKKLVDYLast
1 -269.000[A] KOG2548 SWAP mRNA splicing regulator  ali  100  1MWHEARKQERKIRGLIVDYRKRAERRQYFYDKIQADPTQFLQLHGRRSKIYLDPAVAAAGDGAAIMQGQQDNLIDRFDVRAHLDHIPPVNKTNAEGADGDSELTLEERQLNYERYRILAQNDFLNVSEDKFLHQLYLEEQFGANAQLEAERNLAKKKQKTGGATIGYSYEDTGDGATIGPQPFGAASSTVIGGAAAVAKGEKGDGSEESDSDIDMDVSIDIGKLDTSQAHELNACGRNYGMKSNDFFSHLTKDADEADALRIAREEEQEKMLLSGRKSRRERRAQKERRIANRPFSPPSYAAKEDKDKKGGGKGGEKEKEEDSESRSPSPAEAGPEKITYITSFGGEDEMQPHSKITISLTKPGLTLGESCINASSGAAIAAAAASSVSYAQKVKDNLDKLKVMNESSKRNRRRSRSHSRSRSRSATVSRSRSGSRRSGSRRRSRRSRSYHRRSRTRSRRRRRYYSRSRSRSRSRSRSLSRSRSRSRSRSRSGSWKRYKARSPSYKRSRKRYSYSSRSSSGSSYRRRSRSRSPSNRRSRVKKKTTPPPVATVGGYCLNTTTTTTTSTVTAVKMFQQQQQQPPAKATPPMISYPIPARMLNVNQALTATAPVAVQPQVVEPPPPPLKRYYGRKRGNDTSSSSSSGAENSEGSDNEEQQQPQLGKRAEDSDDMELDTASERSHALQPTMSSSSSTGNQTGKYSSATETGSGHPSSGGGGRPNLRERLKRKMQNLLNRQYKADKRAEIEKTERERLQQQEREDEMRELALKLRRRRRELRHKYGTPSSGKLSDSDAESVASESQLAKSSTRRSRSRSESRRRSPPPETQHSRRSSSRTERRRRTRTPSPKYNRRQRSRSRSGSRVERKRRSHSRRRSGSRDRRRSRSRRSQSRRRRQRDRSIERNREREQYRQQHQQQNERLRGRDRDREADYGHGGSGSSNRGRVVISAPPKLKKLVDY 957
2 -16.700[A] KOG4849 mRNA cleavage factor I subunit/CPSF subunit  ali follow..  20  521..........................................................................................................................................................................................................................................................................................................................................................................................................RRERSRSRERSHRSRQRRERSTSRYRERSRERERDRDRERERDGGRSVRPRKSPEPVVEAAEAPSSKRYYEDRERYRSSDRERR-DRDRDRDRERERDRDRHFTNDGRGLPLDPSNFTSQNPGNIKTGRPKSAAVAGGSMEKPRGQSAWDI............................................................................................................................................................................................................................................................................................................................................................................................................................ 671
3 -11.800[R] KOG4433 Tweety transmembrane/cell surface protein  ali follow..  12  415....................................................................................................................................................................................................................................................................................................................................................................................................................................PASNAPSASISPTAPLSTGTINRTLLHHQQASSGGGSGT------SGGGAGAGGGVGANGHNGVGPYRNGSAGLRQGLASPSSQSSHTSSTATYNNGTTSYHNSHQQHNNHLYSNHYSHSNNHYNNTQHRTN-------PAAGAVAAAVGVVSSGQRSPSPPPVYDLD-----------AFHRTTSNRRRICQDPTMESSSSNTAQQQQQNLQLQQHQQQSNLINQNQSQSTLKNIFASATLPRSTGSSIRSVLSVQTSNAGICRSTGNGLDGDMVDDRDPRDVTNNSFNRFDPKYISIGPKARGQNNNLNIMSVAGGANKCAT-------------------------------LRHRYGGSLKG-VSAVNATPSPAAAPAVHSPNLRS--------------------------KTPSIATVSKDY............................................................................................................. 767
4 -10.200[R] KOG2140 Uncharacterized conserved protein  ali follow..  17  769..........................................................................................................................................................................................................................................................................................................................................................................................................DQNSSGSNWRDPITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKKRGERRNSFSENEKHTHRIKDSENFRRKDRSKSKEMNRKHSGSRS---DEDRYQNGAERRWEKSSRYSEQSRESKKNQDRRREKSPAKQK.................................................................................................................................................................................................................................................................................................................................................................................................................................... 908
5 -10.200[K] KOG0850 Transcription factor DLX and related proteins with LIM Zn-binding and HOX domains  ali follow..  13  90....................................................................................................................................................................................................................................................................................................................................................................................................................ASYRQYGAYREQPLPAQDPVSVKEEPEAEVRMVNGKPKKVRKPRTIYSSYQLAALQRRQYLALPERAELAAQLGLTQTQVK---------W--FQNRRSKFKKLYKNGEVPLEHSPNNS.................................................................................................................................................................................................................................................................................................................................................................................................................................................. 202
6 -10.200[T] KOG2290 Rhomboid family proteins  ali follow..  11  1...........................................................................................................................................................................................................................................................................................................................................................................................MSEARRDSTSSLQRKKP-----PWLKLDIPSAVPLTAEEPSFLQPLRRQAFLRSVSMPAETAHISSPHHELRRPVLQRQTSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCS-QRYGKLKPQVLRELDLPSQDNVSLTSTETPPPLYVGPCQLARGRAFRVADDTAEGLSAPHTPVTPGAASLCSFSSSRSGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFR----------------RARRRSFTPASFLEEDTTDFPDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKAPEQADLTGGALDRSELERSHLMLPLERGWRKQKEGAAAPQPKVRLRQEVVSTAGPRRGQRIAVPVRKLFAREKRPYGLGMVGRLTNRTYRKRIDSFVKRQIEDMDDAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKF-SPCMR.............................................................................................................. 480
7 -10.100[R] KOG2030 Predicted RNA-binding protein  ali follow..  8  433.......................................................................................................................................................................................................................................................................................................................................................................................................KDPEVTVVDVDLALSAWANARRYYDMKRSAAQKEKKTVDASQKALKSAERKTQQTLKEVRTISNIVKARKVFWFEKFYWFISSENYLVIGGRDAQQNEL-----KRYMRPKDIY--------VHAEIQGASSVIIQNPTGEEIPPKT--------LEAGSMAISYSVAWDAKVVTNSYWVTSDQVSKTAPTIRGKKNFLPSCHLTMGLSLLFKLEDSFIERHLGERKVRSLEDDQIDPNVKENEVEHDLLSDNEDADSNINLSEPSSNTEITAFPNTEVKIEHDTGRIIVRSDSVNPEIEETKESEVVLDKILKKTDDEETTIILAGPSRKKQVSAKKTKEDKARAKQEKRGQKGKLKKMKQKYKDQDDEEREIRMMI------------LKSSGKEKPQASADKVVEKSESTKEYVKPEKSAAPKNPVELDDADEVPVGGDVDVLNSLTGQPHEG--------------------PYQ-----QNYKFKVKLTPGTGKRGKAAKLALNIFAKEKSCSAREKDLLKSIKEES-----------------GKVKLSAP-KYHK.... 972
8 -10.100[K] KOG0842 Transcription factor tinman/NKX2-3, contains HOX domain  ali follow..  15  89....................................................................................................................................................................................................................................................................................................................................................................................................................GLAAGAPPQDSSSKSPEPSADESPDNDKETPGGGGDAGKKRKRRVLFSKAQTYELERRRYLSAPEREHLASLIRLTPTQVK---------W--FQNHRYKMKRARAEKGMEVTPLPSPR.................................................................................................................................................................................................................................................................................................................................................................................................................................................. 201
9 -10.100[R] KOG0488 Transcription factor BarH and related HOX domain proteins  ali follow..  10  130.......................................................................................................................................................................................................................................................................................................................................................................................................................SSRRFVKDRFTAAAALTPFTVTRRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRKYLASAERAALAKSLKMTDAQVK---------W--FQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNDSIQPDPLCLHNSS...................................................................................................................................................................................................................................................................................................................................................................................................................... 267
10 -10.000[A] KOG0152 Spliceosomal protein FBP11/Splicing factor PRP40  ali follow..  13  425..........................................................................................................................................................................................................................................................................................................................................................................................QTLKEIVHDKRY-GALRTLGERKQAFNEYLGQRKKVEAEERRRRQKKAREEELSSSLKWSKAMSLFENDQRFKAVDRPRDREDDNYIVELERKEREKAAEEHRQYMADDYIKAGTQWRKIQDR-----EDDDRCSCLEKIDRLIGFEELDLEKEEEELKRVEKEH-------------------------------VRRAERKNRDAFRTLLEEHVAAGILTAKTY---------------------LDYCIELKDLPQYQAVASNTSGSTPKDLFEDVTEELEKQYHEDKSYVKDAMKSRKANFKSAISEDLSTQQISDINLKLIDDLVGRVKEKEEKEARKLQRLAEEFTNLLHTFKEITVASNWEDSKQLVEEESVSQGLFEEYITSLQEKAKEKERK----KEKERDEKEKRKDKDKERREKEREREKEKGKERSKREESDGETAMDVSEGHKDEKRKGKDRDRKHRRRHHNNSDEDVSSDRDDRDESKKSSRKHGNDRKKS--------RKHANSPESESENRHKRQKKESSRRSGNDELEDGEVG............................ 945
11 -9.890[O] KOG0314 Predicted E3 ubiquitin ligase  ali follow..  19  579....................................................................................................................................................................................................................................................................................................................................................................................................................SSPERQSSRRFTSPPRSSSRKSERDRHHDLDSHDRRRDRPRETDRKHRKRSEKSSSDPTVEIDDNNKSNVFTRISFPEESSGKQRKTSKSSPAPPESSVAPVSSGRRHHSRREREMVEYDSSDDEDRHFKRKPSRYKRSPSVAP......................................................................................................................................................................................................................................................................................................................................................................................................................... 723
12 -9.840[R] KOG2714 SETA binding protein SB1 and related proteins, contain BTB/POZ domain  ali follow..  13  386........................................................................................................................................................................................................................................................................................................................................................................................................................................IEIAYGTSSGAVRVGSGPQLFQTFTVHRSPVTKIMLSEKHLVSVCADNNH--RTWTVTRFRGMISTQPGSTPLASFKILSLEETESHGSYSSGNDIGPFGERDDQQ--PITNKLFVRLSSTGKRI------CEIQAVDCTTISSFTVRECEGSSRM--------------PRRYL----------------------------FTGHTNGSIQMWDLTTAMDMVNKSEDKDVGGPTEEELLKLLDQCDLSTSRCATPNISPATSVVQHSHLRESNSSLQLQHHDTTHEAATYGSMRPYRESPLLARARRTESFHSYRDFQTINLNRNVERAVPENGNLGPIQAEVKGATGE------CNISERKSPGVEIKSLRELDSGLEVHKIAEGFSESKKRSSEDENENGFEGGGFLGRKKLASSPSTSDGGTDSPGTASPS--------PTKTTPSPRHKKSDSS----------QEYSL.......................................................... 815
13 -9.760[R] KOG0492 Transcription factor MSH, contains HOX domain  ali follow..  15  117..................................................................................................................................................................................................................................................................................................................................................................................................................................QEPGRYSPPPRHMSPTTCTLRKHKTNRKPRTPFTTSQLLALERKQYLSIAERAEFSSSLNLTETQVK---------W--FQNRSAKAKRLQEAELEKLKMAAKPM.................................................................................................................................................................................................................................................................................................................................................................................................................................................. 215
14 -9.450[A] KOG2217 U4/U6.U5 snRNP associated protein  ali follow..  23  100..........................................................................................................................................................................................................................................................................................................................................................................................................AKLRDARESSNRDKERDSGRDRELLRERERERDRERERDRDREKEREREREKERLREREEREREREKERIREREKERLRERERERERERVRELTAPPPPQISKHAEYESRREREIERERDARKRSGRERERERNRERSRSQSPASSSRKPA............................................................................................................................................................................................................................................................................................................................................................................................................................ 250
15 -9.440[R] KOG2295 C2H2 Zn-finger protein  ali follow..  9  1...................................................................................................................................................................................................................................................................................................................................................................................................................MGDSDDEYDRKRRDKFR-GERESYRTERRDD--RRPVGGSAGARDEWAERNPFRGGASAG---GGGARHRPDYSDYRGPGARPRYGS--------VRDLPPAKRMRPDWGDGDVRANPRFGGYDPYLMQAWNDHYQSMHSAYSHGGHAPPV---GGGDTLTQPAMLNLKQFLDTQD----------------------ENISDSEVMRKYTEYKTDFKRQQLNEFFVAHKDEEWFKNKYHPEDSVKRSEEQRGFLQRRTDV--GSVKVDSSQADALIRVLDTCVIKLEGGTDEDLKVLDEKPKDPVVYERKAEQMQSVKEVEKTINSPKEEMSEADPVSTQRKPVRPVNSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKA-GPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGKDKVVETETIDLDKVKDGQPRALHRTSSIFLNLAPSITR.... 528
16 -9.390[R] KOG0151 Predicted splicing regulator, contains RRM, SWAP and RPR domains  ali follow..  18  830............................................................................................................................................................................................................................................................................................................................................................................................LEEQGMKNSEEIERKVAIHRKRLEADGLSGNQRVLPEKREKREDSRDSSRKRNRSESQNRSQSPPQKSLTRERVRDHDLDKDRHRDRDRQQHDLDKDRKRRAKSSSRERDDH---DRSRERDRDWRRRGMR.............................................................................................................................................................................................................................................................................................................................................................................................................................................................. 957
17 -9.220[R] KOG1855 Predicted RNA-binding protein  ali follow..  19  692..........................................................................................................................................................................................................................................................................................................................................................................................................SMQFERTFSNASESSGFYRRPSNIEREPIQTDQLVGGGGGGYQVWPRRYSNNFQQLSSKL-AAYDNAQYIGGRRISTDSGYDRRCSFG-FEGSPRSRTGSFLSNYKHGGGDSRTGSFLDGSPRSRSGSFAQAESLVRTPMGRARKFGQTISP........................................................................................................................................................................................................................................................................................................................................................................................................................... 865
18 -9.140[K] KOG0847 Transcription factor, contains HOX domain  ali follow..  13  157............................................................................................................................................................................................................................................................................................................................................................................................................................................SMQLSPNSLNMQKKQSRPTFTGHQIYQLERKEQTKYLAGADRAQLAQELNMSESQVK---------W--FQNRRTKWRKKEAADNALVKRGASGDKSPCSLSPFLS....................................................................................................................................................................................................................................................................................................................................................................................................................................... 253
19 -9.130[K] KOG0848 Transcription factor Caudal, contains HOX domain  ali follow..  10  150....................................................................................................................................................................................................................................................................................................................................................................................................................TAAAEQLSPGGQRRNLCEWMRKPAQQSLGSQVKTRTKDKYR---VYTDHQRLELEKESRYITIRRKAELAATLGLSERQVK---------W--FQNRRAKERKINKKKLQQQQQQQPPQPPPPPPQPPQPQPGPLRSVPEPLSPVSS...................................................................................................................................................................................................................................................................................................................................................................................................................... 287
20 -9.090[K] KOG0844 Transcription factor EVX1, contains HOX domain  ali follow..  14  144....................................................................................................................................................................................................................................................................................................................................................................................................................SGSEALVGSPNGGSETPKSNGGSGGGGSQGTLACSASDQMRRYRTAFTREQIARLEKENYVSRPRRCELAAALNLPETTIK---------W--FQNRRMKDKRQRLAMTWPHPADPAFYTYMMSHAAAAGG...................................................................................................................................................................................................................................................................................................................................................................................................................................... 268
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Ye Y, Osterman A, Overbeek R, Godzik A. Automatic detection of subsystem/pathway variants in genome analysis. Bioinformatics. 2005 Jun 1;21 Suppl 1:i478-i486.