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Query: [TZ] KOG2272 Focal adhesion protein PINCH-1, contains LIM domains, from COG0516

Results of FFAS03 search in COG0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSLGAMHCTRCADGFEPTEKIVNSNGELWHTQCFVCAQCFRPFQDGIFYEFEGRKYCERDFHVLFAPCCNKCGEFVIGRVIKAMSASWHPQCFRCQLCAKELADCGFIKNQNRALCHECNAKVKAEITGRYVCQKCHGLIDEEPLRFRGEVYHGYHFSCTACGTELDSTAREVKSRPGLAANDMNELYCLRCHDKMGIPICGACRRPIEERVVTALGKHWHVEHFVCAKCEKPFLGHRHYEKRGLAYCETHYHQLFGNLCFVCNQVIGGDVFTALNKAWCVHHFACSVCDTKMTQKSKFYEYDEKPVCKKCYDRFPNELRRRLRTAHEMTMKKNTLast
1 -100.000[TZ] KOG2272 Focal adhesion protein PINCH-1, contains LIM domains  ali  100  1MSLGAMHCTRCADGFEPTEKIVNSNGELWHTQCFVCAQCFRPFQDGIFYEFEGRKYCERDFHVLFAPCCNKCGEFVIGRVIKAMSASWHPQCFRCQLCAKELADCGFIKNQNRALCHECNAKVKAEITGRYVCQKCHGLIDEEPLRFRGEVYHGYHFSCTACGTELDSTAREVKSRPGLAANDMNELYCLRCHDKMGIPICGACRRPIEERVVTALGKHWHVEHFVCAKCEKPFLGHRHYEKRGLAYCETHYHQLFGNLCFVCNQVIGGDVFTALNKAWCVHHFACSVCDTKMTQKSKFYEYDEKPVCKKCYDRFPNELRRRLRTAHEMTMKKNT 335
2 -64.000[TZ] KOG1044 Actin-binding LIM Zn-finger protein Limatin involved in axon guidance  ali follow..  16  1..MYGTRCHGCGEFVE--GEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRPMSSSPKETTFSSNCAGCGRDINGQALLALDKQWHLGCFKCKSCGKVLTGE-YISKDGAPYCEKDYQGLFGV-----KCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYL--------QGSTVWHPDCKQSTKTEEKLRPTRTSSESIYSRPGSSIPGSPGHTIYAKVDNEILDYKDLAAIPKVKAIYDIERPDLIEPFYTSGYDDKQERQSLGESPRTLSPTPSAEGYQDVRDRMIHRST.............................. 299
3 -48.200[T] KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins  ali follow..  21  358....DPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHL------TKKMLYDMENPPADEYFGRCARCGENVVGEGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLE------QCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPF--------TVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPIVALDRDFHVHCYRCEDCGGLLSNQGCYPLDGHILCKTCNSARIRVLTAKASTDL.................................................................... 612
4 -38.400[TZR] KOG1704 FOG: LIM domain  ali follow..  11  105QDSDVRYCEDLNAE-TRKTECLGSGVVQYAPFDTKCEKMLQGSPDIKFQLPKLK---RPPIKMQYDSNIFDFQVIFGDECLEAEGRSWHFHHFQCAQCNDVLADQKYMQRANKPVCLKCFHSSSST----FSCTTCRLSFDTPHMSQGDLHWHAECFCCCVCSKNLLGVKYSRVG---------ESLFCGYQTCGGEDEELLDEDRLGSPRVAPRHPHVIQQNLTTTMTIQKPSVVIQNQRPKPPQRAPPPPPSENIYETVLPCSSNNSPNFDKKYSHELPTSPNHHNYYSKTPNNLLTGYPEMDGYSTSSSSD..................... 433
5 -33.300[K] KOG4577 Transcription factor LIM3, contains LIM and HOX domains  ali follow..  26  28......................................................................................................................................................................................................PQCAGCNQHILDKILKVLDRHWHSSCLKCADCQMQL-ADRCFSRAGSVYCKEDFFKRFGTKCTACQQGITQVVRKAQDFVYHLHCFACIICNRQLATGDEFYMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITA. 166
6 -31.900[R] KOG0490 Transcription factor, contains HOX domain  ali follow..  16  3.....VHCAGCERPILD-RFLLNVLDRAWHIKCVQCCECKTNLSE-KCFSREGKLYCKNDFFRRFGTKCAGCAQGISPSVRKARSKVFHLNCFTCMVCNKQLSTGEYVIDENKFVCKDDYLSSSSLKEGS----------LNSVSSCTDRSLSPDLQDALQDDPKETDNS----------TSSDKETANNENEEQNSGTKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQET................................................................................................. 217
7 -22.000[K] KOG2461 Transcription factor BLIMP-1/PRDI-BF1, contains C2H2-type Zn-finger and SET domains  ali follow..  388......FVSPVAQTTAAITATGGRSGQPIDVQPVLAATAGAHFGNYAAIYGSQD-FQHELSKPLYTSASPAFGGGGGMGGGFGMGGSAHTSHSSSSHNDSSFNGVPNYVQQKTRYCKDCVHVRTHTGERPFKCEICTKEFTQLAHLQKHHLVHERPHRCDICDKRFSSTSNLKTHLR---LHNGQKPY-----------TCDVCDAKFTQYVHLRLHKRLHARPYSCGTCGKKYISPSGLRTHWKTTEDMKDSMRDDLEIDEGSMSGSGYGNLGIFENTLELKRPLMPIETIYSKYNLPNA-------SLLGQGPSGMQEQQAPPPTSQQQQHMM 734
8 -21.000[K] KOG2462 C2H2-type Zn-finger protein  ali follow..  10  96......SSVHHHHGEQGEILNSTSLLE----DEHICPECGKKYSTSSNLARHRQTHRSIMDKKAR--HCPYCEKVYVSMPAYSMHVRTHNQGCECQFCGKRFSRPWLLQGHIRTHTGE----------KPFKCGVCEKAFADKSNLRAHIQTHSKPHTCARCGKAFALKSYLYKHEESSCMKNRGGV-GAASGNRPPSSAAAVCAASDSAKSTLANKLLQKEDRRQAAMAFQGFPAGPEVTAYSHATSQEEYE------KFKRINVIQPKVMPHRVPSLYQD-NRHVPLALPLAMPYHFQGQATSTGQSDPTS------VQEQPVDFSPKNN... 422
9 -17.600[O] KOG2231 Predicted E3 ubiquitin ligase  ali follow..  15  17....RPKDGVANTTTDNAAVKPEALESYTGNDDNACVVCFKNVEIFSIGD------CDH-------PVCYECST------MRVLCQQNE-----CPICRHVLSKVLFTLDKLPDLYSKKYRIGFCTAE-DHPCPKCDAPPYRTFLRNHVRSEH-KLLYCDLCVETLNIFTFERRCYTQAELQLHNTKGDPDNRSHRGHPLCEYCNKRYVDR--DELFRHLRREHYFCHFCDADGCNEFYNDYA------------------------------DLAEHFRAEHFLCEECATE........................................... 270
10 -16.000[R] KOG3608 Zn finger proteins  ali follow..  10  2..........LRPQSSVPAPQPPGKRKKPAELELTCRDCQEICTGEWSLNGHIGDHLEHYAKAQDDRQCNSCDFRTENQVEFERHSYYHGQNFRCTDCEREFVSIVEFQDHIVKHALFEYDIQKTPEDERPKWAMCHKHMGNKYRLIEHISTHSN-VACFHCGELFRTKTTLFDHLR-RQPENNTNSF-----------QCAQCFKFFATKKLLKSHVVRHVNCYKCTMCDMTCSSASSLTTHIRYR----HLKDKPLKCSECDTRCVRESDLAKHVQIVKTVHQCEHCHYSVRTYTQMRRHFLEVH-----NNPILYACHCCERFFKSGKS... 364
11 -14.200[R] COG5236 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  14  33....NFRRKQKKNNLSAEPNLTTSSADDTDEENELCVICARKLTYVSLTP------CHH-------KTCHIC----------GFRQRALYNKKSCLICRTENEEVMFTDRIDGDISDKYNFCEKNEKYGKFFCPLSKDEQVCDFGSFKKYNEHLKSMICLICLEIFTQNQLRNHQTKGNSEGFKGHPMCAFCSGKRF----------------DELYIHMRNQHEKCHICDKMNPASPQYFKD----------------------------YNQLFDHFKHSHYVCTVQTCLDNKFVVFKDE................................. 296
12 -13.900[K] KOG1168 Transcription factor ACJ6/BRN-3, contains POU and HOX domains  ali follow..  175....HMMSHHHPGTLSG-HTGGHHGHSAVHHPVITAAVAAAGLHPDTDTDPR-ELEAFAERFKQRRIKLGVTQADVGKANLKLPGVGALSQSTICRFESLTLSHNNMIA---KPILQAWLEEAEAQAKNKRR-KRKRTSIAAPEKRSLEAYFAVQPRPSGEKIAAIAEKLDLKKNVVRVW-------FCNQRQKQ............................................................................................................................................ 368
13 -12.400[R] KOG4377 Zn-finger protein  ali follow..  13  303..................................FNEDC-------------GFERCGYRNHQSH--HCRDCHYSFCDKTRFVQHTARHER-------MDTLMGDDFRQFRANMQCGVASCGYATASGAAETNHLSRIDPTEAVTASSRKTSH---FHCRKCDYVCTDSNKVVAHRR---LHLRQDYVRNAGFRKVGG--NEQCDSPGCSYAQRH-------THYHCVTCDGGVLSRAQLAAHKHRT........................................................................................ 482
14 -12.000[R] COG5048 FOG: Zn-finger  ali follow..  507................QFGTHIKEINTYTTNSPSKITRKLTTLPRGSIDKYVKEM--DKTFE------CLGCTKTFKRRYNIRSHIQTHLE-YSCDHCDKAFVRNHDLIRHKKSHQEKAYA-----------CP-CGKKFNREDALVVHRSRMGKKYENVVIKRSPRKRGRPRKDGTSSVSSSPIKENINKDHNGQLMFKLEDQERSYDGNGTGIMVSPMKTN................................................................................................................ 707
15 -11.700[K] KOG2482 Predicted C2H2-type Zn-finger protein  ali follow..  12  47......PCIFCEEHFPVAEQ--DKLLKHMIIEHKIVIADVKLVADFQRYILYWRKRFTE------QPITDFCSVIRINSTAPFEEQENYF--LLCDVLPEDRILREELQKQRLREILEQQQQERNDTNFHGVCMFCNEEFLGNRSVILNHM-KLDNLQCLYCEKTFRDKNTLKDHMRKKQHRKINPINYLELGKSWEEVQLEDDRELLDHQEDDWSDWEEHPASAVCLFCEKQAETIEKLYV----HMEDAHEFDLLKIKSELGLNFYQQVKLVNFIRRQVHQCRCYGCHVKFKSKADLRTH................................. 363
16 -11.600[S] KOG4367 Predicted Zn-finger protein  ali follow..  13  9......KCPVCGSFYRE---ILPCS----HN---LCQACARNISYGGFASAPTTPCQKSPNGVRVFPPAMPPPATH---LSPALAPVPRNSCITCPQCHRSLDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQ-----DVFYCDPCRLRCHPPRGPLAKHRLVPPAQGKVSTCTDHELENHSMYCVQCKMPV------------------CYQC......................................................................................................... 252
17 -11.500[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali follow..  17  753.............................................................................................................................................................LCIFCGER----------SESFTEEGLDLHYWKHC----MLTRCDHCKQVVE---ISSLTEHLLTEC-KCYRCSEAVFKEELPRHIKHKDCNPAKPEKLANRCPLCHENFSPG-----EEAWKAHLMGPAGCTMN........................................... 872
18 -10.800[S] KOG4623 Uncharacterized conserved protein  ali follow..  40....RVNCWFCNGNVRVPYQ---------DRNSWTCPSCEQ--KDGDYNRDITSQRDCSLGSQKNSSKGSSSICANSYYSDVLTAQPPAPKNGLCDQCNEAQR-SQFEPKNESRFDQELKVYRERLEKQFRLCSSCERHVNKVL............................................................................................................................................................................................... 178
19 -10.600[T] KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains  ali follow..  13  341...............................QQWKCAACRQSLHTHRFCDYYGLFFCSLCHGGEKSILPARVELPVSDRAQRFLRAVRESPVFRIRDLPGDL----VKKNKALRAVVELRQKLKHMEGFIKICIDASNQVFEFGNLSTMFASIDRYLLEHDDLFSLNDLQRIYNKDLLSLLEPLAKRAREHIIH------CKKCRL----------------QAPVCVRCNDM------------------FEERAVSRCEGCGHL------------SHSPKCPCPKCAR............................................ 575
20 -10.400[R] KOG3002 Zn finger protein  ali follow..  14  52..............................YELLECPVCTNLMYPPIHQCPNGHTLCSSCKLRV-QNTCPTCRYELGNIRCLALEKVAESLEVPCRYCQDIFPYYSKLKHEQH--CR------FRSYSCPYAGSECSVTGDIPTLVDHLKDDHKV.................................................................................................................................................................................... 171
21 -10.200[KL] COG5151 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1  ali follow..  16  224.....................IVGLAAEVAICKEICNKTNSSTKNAYGVVISEQHFRELLLESTIPPATDSAKTTDASLVMMGFPSKVVEQLPSLCACHSIPSRGGF-------HCPRCKAKV------------CTLPIE-----------------CPSCSLVLILSTHLARSYHHLFPLKNWSEIPWSANPK--STHCFACQLPFPKPPVSPFDESTSSMRYACPSCKNHF-------------------------CLDCDVFA------------HEQLHECYGCQCS........................................... 419
22 -10.200[KL] KOG2807 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1  ali follow..  16  224.....................IVGLAAEVAICKEICNKTNSSTKNAYGVVISEQHFRELLLESTIPPATDSAKTTDASLVMMGFPSKVVEQLPSLCACHSIPSRGGF-------HCPRCKAKV------------CTLPIE-----------------CPSCSLVLILSTHLARSYHHLFPLKNWSEIPWSANPK--STHCFACQLPFPKPPVSPFDESTSSMRYACPSCKNHF-------------------------CLDCDVFA------------HEQLHECYGCQCS........................................... 419
23 -10.000[O] KOG1814 Predicted E3 ubiquitin ligase  ali follow..  14  161......................NAKLLEFQIRKFQCNVCFDEFNGTDCFQLTGHVSCQSCLRDYYTMCCLDCGKDAPVLTLKELESIVGVQLT--NRYKELEEKRRYENDSNIIFCPR---------------SFCQGPSKRDPGQKLAICQKCDFAFCSFCQATWHGDLSPCKLEGDSKKLVEMYLNYQENEPEKALELEKRYGKRIIDRLVEQVKNDEEAEKWVCPTCDRVVERID---------CCH-------MNC-LCGTHF------------------CFLCGAYLMEQNPYKHFNDP---SSCYGMLF................... 421
24 -9.470[D] KOG2186 Cell growth-regulating nucleolar protein  ali follow..  5...................................................................QCDDCGENLKKPRLPRHMSMCTATKFSCIDCGNMFGQVSV---HYHNQCITEAEK-YGPMVRSNGESSKQKHDFDINAELFNSQWF-----CSLCNATMTCEQDYFAHVYGKHQEKANEVADMDYSKQQSEHPAVDKNNLTQQPDLDIYVGLSNDYPWFCSLCDINATSEQTLLAH............................................................................................ 172
25 -9.410[O] COG0068 Hydrogenase maturation factor  ali follow..  13  104....AATCPEC------QREIFDPFSRFYRYPFTNCTHC-----GPRLSIIRAIPYDRCNTSMSAFVMCPECED----SYHDVENRRFHAQPVACHTCGPKA---WLERADGKPVTAS------MFSMLDDVDAVCTLLQKGEIVAIKG--FH------LACDATQEAAVEKLRQRKRRYDKPFALMARDINVIEKYCFVNDRERELLVSPAAPIVLLEKRTEEISSFPIASTVAPGQNTLGFMLP-----YTPLHHLILKRMNRPI---VLTSGNIADEPQCVANDEAKEKLSHIADYFLLHNREIVNRVDDSV.................... 377
26 -9.400[O] KOG1815 Predicted E3 ubiquitin ligase  ali follow..  10  103.RVHDEWFADEERVRKTVGILESHVVPPSDDSELTCGICFDSYPPEKIASVSGHPFCTTCWTGYISTTCPSCLAAVGHDMVDKLASEDEKEKYNRYFLRSYIEDNRKGLEIMMFPACARLAFAGMILANSKPCPRCKRPIEKN-MTCTPPCKYEFCWLCYACNRYEVAKQEGQSRQKAMADLQQAQMQNVRLVMFFRILLLSESLRLFISKLSDKQCTPESQLKFIIIECRRVLK--GYYLPEHEHAKRQFFEYLQGEALERLHQCVEKDLVQFLIAEGPSKDF--NDFRTKLAGLTSVTKNYFENLVKALENGL.................... 458
27 -9.290[P] COG3303 Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit  ali follow..  11  119...................................................GGYAFAKE-YNAPRGHFYAVTDVRNILRTGAPKTANDGPQAMACWTCKGPDVPRLIAEWGEKDYFNAKWAKGGPEIVNSIGCADCHDTTSKDFAEGKPALRIARPHVLRALDAL---EKATAEKDKAEGRPHNNLSFNTAARTEKRAEICANC----------------HVEYYF-KQVTFPWDNGQTVDDIEKYYDDIGFTDWTHSLSKAPMLKAQHPDFEIWSLGMHGKNVTCVDCHMPKVQGADGKVYTDHQIQNP---EAFDSTCANCHDQSKEKLRDIV 384
28 -9.240[DR] KOG4739 Uncharacterized protein involved in synaptonemal complex formation  ali follow..  17  2...............................DWIQCNHCGIKPNQTKLYLTAGHVFCQNCTKAAFNSQCYLCKKPLKVDEIN............................................................................................................................................................................................................................................................. 53
29 -9.230[R] KOG4299 PHD Zn-finger protein  ali follow..  14  266...................................CSACHG----------PGNFLC-----------CETCP------------NSFH---FTC--IDPPIEEKNL---DDAWYCNECKHHSLYNELDEQEELESNVKEEGTMVDVWMQLCTYI--------DSHNPIQFHLPHSISSFFRGVGSGVMGEYIETDVLKHLKSSRRSNGEERDPLLLKSKSGTPILCFRCHKSALVSQSILA-----------------CDYC------------NSYWHPDCWKCPNHSDHVTPR....................................... 463

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.