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KOG2272
Query: [TZ] KOG2272 Focal adhesion protein PINCH-1, contains LIM domains, from COG0312

Results of FFAS03 search in COG0312
Master-slave alignment does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSLGAMHCTRCADGFEPTEKIVNSNGELWHTQCFVCAQCFRPFQDGIFYEFEGRKYCERDFHVLFAPCCNKCGEFVIGRVIKAMSASWHPQCFRCQLCAKELADCGFIKNQNRALCHECNAKVKAEITGRYVCQKCHGLIDEEPLRFRGEVYHGYHFSCTACGTELDSTAREVKSRPGLAANDMNELYCLRCHDKMGIPICGACRRPIEERVVTALGKHWHVEHFVCAKCEKPFLGHRHYEKRGLAYCETHYHQLFGNLCFVCNQVIGGDVFTALNKAWCVHHFACSVCDTKMTQKSKFYEYDEKPVCKKCYDRFPNELRRRLRTAHEMTMKKNTLast
1 -101.000[TZ] KOG2272 Focal adhesion protein PINCH-1, contains LIM domains  ali  100  1MSLGAMHCTRCADGFEPTEKIVNSNGELWHTQCFVCAQCFRPFQDGIFYEFEGRKYCERDFHVLFAPCCNKCGEFVIGRVIKAMSASWHPQCFRCQLCAKELADCGFIKNQNRALCHECNAKVKAEITGRYVCQKCHGLIDEEPLRFRGEVYHGYHFSCTACGTELDSTAREVKSRPGLAANDMNELYCLRCHDKMGIPICGACRRPIEERVVTALGKHWHVEHFVCAKCEKPFLGHRHYEKRGLAYCETHYHQLFGNLCFVCNQVIGGDVFTALNKAWCVHHFACSVCDTKMTQKSKFYEYDEKPVCKKCYDRFPNELRRRLRTAHEMTMKKNT 335
2 -77.700[T] KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins  ali follow..  21  343.PGMYPVTGPKKTYIT--DPVSAPCAPPLQPKGGHSGQLGPSSVAPSFLTKKMLYDMENPPADEYFGRCARCGENVVGEGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTL--------------------------------------------------------------------------EQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTDAGGLIHCIEDFHKKFAPRCSVCKEPIMPARIVALDRDFHVHCYRCEDCGGLLSEGDGCYPLDGHILCKTCNSARIRVLTAKASTDL........ 612
3 -68.200[TZ] KOG1044 Actin-binding LIM Zn-finger protein Limatin involved in axon guidance  ali follow..  16  1..MYGTRCHGCGEFV--EGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGQPMSSSPKETTFSSNCAGCGRDINGQALLALDKQWHLGCFKCKSCGKVLTGEYI--------------------------------------------------------------------------SKDGAPYCEKDYQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTEGEMYLQGSTVWHPDCKQSTKTEEKLRPESIYSRPGSSIPGSPGHTIYAKVDNEILDYKDLA-AIPKVKAIYDIERPDLITYEPFYTSGYDDKQERQSLG 272
4 -55.600[TZR] KOG1704 FOG: LIM domain  ali follow..  13  96........................................RQSRYQLPPQDSDVRYCEDLNAEEAD-TLRMFERTRKTECLGSGVVQYAPFDTKCEKMLQGSPDIKF---QLPKLKRPPIKMQYDS-----NIFDFQVIFGDECLEAEGRSWHFHHFQCAQCNDVLADQKYMQRA---------NKPVCLKCFHSSSSTSCTTCRLSFSSDHMSQGDLHWHAECFCCCVCSKNLLGVKYSRVGESLFCGYQTELLDEDRLGSPHRKVTQRVAPRHPHVIQQNLTTTMTIQKPSVVIQNQRPKPPQRAPPPPPSENIYETVLPCSSNNSPNFDKKY 395
5 -45.400[R] KOG0490 Transcription factor, contains HOX domain  ali follow..  17  1...MMVHCAGCERPIL-DRFLLNVLDRAWHIKCVQCCECKTNLSEK-CFSREGKLYCKNDFFRRFGTKCAGCAQGISPSVRKARSKVFHLNCFTCMVCNKQLSTG-----------------------------------------------------------------------EELYVIDENKFVCKDDYLSSSSLKEGSLNSVSSCTDRSLSPDLQDALQDDPKETDNSTSS------DKETANNENEEQNSGTKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSK..................... 234
6 -43.000[K] KOG4577 Transcription factor LIM3, contains LIM and HOX domains  ali follow..  14  1..................................MMQSATVPAEGA----VKGLPEMLGVPMQ-QIPQCAGCNQHILDKILKVLDRHWHSSCLKCADCQMQLADRCFSR--------------------------------------------------------------------------AGSVYCKEDFFKRFGTKCTACQQGITQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEATITAKQLETLKNAYKNSPKPARHVREQLS-SETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSV 231
7 -22.200[K] KOG2462 C2H2-type Zn-finger protein  ali follow..  96......SSVHHHHGEQGEILNSTSLLED-----HICPECGKKYSTSSNLARHRQTHRSIMDKKARH--CPYCEKVYVSMPAYSMHVRTHNQGCECQFCGKRFSRPWLLQGHIRTHTGE----------KPFKCGVCEKAFADKSNLRAHIQTHSN-HTCARCGKAFALKSYLYKHEESSCMKNRGGVPGSGAASGNRPPSSPKRQQAEV-----TSGTISAPGSPAAAVCAASDSAKSTLANKLLQKEKDRRQAAMAFQGFPAGPEVTAYSHATSAQEEYPSLYQDLLPNRHVPLALPLAMPYHFQGQATSTGQSDPTSVQEQPVDFSPKNN... 422
8 -18.900[R] KOG3608 Zn finger proteins  ali follow..  11  26......TCRDCQEICTGEWSLNGHIGDHLEHTEHQCNSCDFRTENQVEFERHSYYHGYYLNLLLQGKECDLHPEIPACTAPARLMEKLPGQNFRCTDCEREFVSIVEFQDHIVKHALFEYDIQKTPEDERCNWAMCHKHMGNKYRLIEHISTHSN-VACFHCGELFRTKTTLFDHLRRQPENNTNSF------------QCAQCFKFFATKKLLKSHVVRHVNCYKCTMCDMTCSSASSLTTHIRYR----HLKDKPLKCSECDTRCVRESDLAKHVQIVKTVHQCEDCHYSVRTYTQMRRHFL----EVHGNNPILYACHCCERFFKSGKS... 364
9 -17.800[K] KOG2461 Transcription factor BLIMP-1/PRDI-BF1, contains C2H2-type Zn-finger and SET domains  ali follow..  483......SSSHNDSSFNGV----PNYVQQQENTRYACKDCNKTFGQLSNLKVHVRTHTGERPFK-----CEICTKEFTQLAHLQKHHLVHTG-HRCDICDKRFSSTSNLKTHLRLHNGQ----------KPYTCDVCDAKFTQYVHLRLHKRLHAN-YSCGTCGKKYISPSGLRTHWKTTTCKEEDMKDSMRDDLMDIKGEIDEGSMSGSGYGNLGIFENTLNLKRPLMPIETIYSKYNLPNASPSGMAPPPTSQQQQHM-LQGPPPPPQHFQMDHSGMQNGG-HQHQLIQGGPSSGSGQQQHPQHNGIHRLPD------LKNPLLPSLG...... 812
10 -15.700[R] COG5236 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  11  33....NFRRKQKKNNLSAEPNLTTSSADDTDEENELCVICARKLTYVSLTP--HHKTCHICGFRQRAKSCLICRTENEEVMFTDRIDGDISD-EKNEKYGINFTSEEVATETLNLL--------------KFFCPLSKDEQVCDFGSFKKYNEHLKCLICATHKHAFPCELEIFTQNQL-----RNHQTKGNSEGFKGHPMCAFCSG---KRFYSDDELYIHNQHEKCHICDKMNPASPQYFKDYNQLFDHFKHSHYVCTVQTCLDNKFVVFKDELELQAH....................................................... 302
11 -14.200[R] KOG4299 PHD Zn-finger protein  ali follow..  11  266...................................CSACHG----------PGNFLC-----------CETC------------PNSFHFTCWYCNECKHHSLYNELDEQEELESNVKEEGTMVDVWMQLCTYIDSHNPIQFHLPHSISSFFRYIETDVLKHLKSSRRSNGEERDPLLLKSKSGTPILCFRCHKSALVSACDYC------------NSYWHPDCWKCPNHSDHVTPRYRLPEKAKV......................................................................................... 472
12 -14.100[O] KOG2231 Predicted E3 ubiquitin ligase  ali follow..  13  17....RPKDGVANTTTDNAAVKPEALESYTGNDDNACVVCFKNVEIFSIGD------CDH-------PVCYECSTRMR------------CQQNECPICRHVLSKVLFTLDKLP--------YRELEANNRSDLYSKKYRIGFCTAEIRQQFFKLLDHPCPKC------------DAPPYRTFEGLRNHVRSEHKLLYCDLCVETLNIFERRCYTQAELQLHNTHPLCEYCNKRYVDRDELFR---------HLRREHYFCHFCDADGCNEFYADLAEHFRAEHFLCEKCATEQFVGAFRNEIEYKAHVANVHGKSLNKQQAKQTRTLQVEITLGP 313
13 -13.100[P] COG3303 Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit  ali follow..  47LSLFNSATAELVYKPLEQPVEPAKPDLKIESVNEKFAEKYPNQYNSWRSTANGDGEFAKEYNAPRGHFYAVTDVRNILRTGAPKTANDGPQAMACWTCKGPDVPRLIAEWGEKDYFNAKWAKGGPEIVNSIGCADCHDTTSKDFAEGKPAL---RIARPHVLRALDALEKATAEKDKAEGRPHNNLSFNTAARTEKRAEICANCHVEYYFAGDIKQVTFPWDNGQTVDDIEK---------YDDIGFTDWTHSLSKAPMLKAQHP----DFEIWSLGMHGKNGVTCVDCHMPKVQGADGKVYTDHQIQNP--FEAFDSTCANCHDQSKEKLRDIV 384
14 -13.100[R] COG5048 FOG: Zn-finger  ali follow..  10  525......KITRKLTTL--PRGSIDKYVKEMPDKTFECLGCTKTFKRRYNIRSHIQTHLED--------SCDGCDKAFVRNHDLIRHKKSHQE-YAC-PCGKKFNREDALVVHRS-----------------------------RMICSGGKKYE-----NVVIKRSPRKRGRPRKDGTSSVSSSPIKENINKDHNGQLMFKLEDQERSYDGNGTGIMVSPMKTN................................................................................................................ 707
15 -12.600[O] KOG0006 E3 ubiquitin-protein ligase (Parkin protein)  ali follow..  10  210.......CITCTDVRSPVLVFQCNSRHVI------CLDCFHLYCVTRL--NDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRY------QQYGAEECVLQMGGVLCP---------------RPGCGAGL---LPEPDQRKVTCEGGNGLGCGFAF----------------------------------CRECKEA------------YHEGE-CSAVFEASGTTTQAYRVDERAA-SKETIKKTTKPCPRCHVPVEKN-----GGCMHMKCPQCWNCGCEWNRVCMG.................................... 431
16 -12.500[R] COG5141 PHD zinc finger-containing protein  ali follow..  15  194....DGRCVICNEAECENSNAI-----------VFCDNCNTSVHQNCYFVPEGQWFCKKCLLAPHEVICAFCPDR-DGAFCTTLDGRWH------TICAIAIPEISFHDTSRL------------------------DLVRNIASIPKSR------LVCCICKLRWGT--------------------------------CVQCSD-------KNCYAAYHI---TCARYKIYSHSASYDSVDMETYCDKHTPPDYLNG............................................................................ 370
17 -12.100[R] KOG3002 Zn finger protein  ali follow..  17  52.............................................................................................................................................................................................................................YELLECPVCTNLMYPPIHQCPNGHTLCSSCKLRV-QNTCPTCRYELGNIRCLALEKVAESLEVPCRYCQDIFPYYS---KLKHEQHCRFRSYSCPYA-GSECS........... 153
18 -11.600[K] KOG2482 Predicted C2H2-type Zn-finger protein  ali follow..  10  20....SKDCILEPLSLPESPGGTTTLEGS---PSVPCIFCEEHFPVAEMIIEHKIVIADVKLVADFQRYILYWRKRFTEQPITDFCSVIRINSGVCMFCNEEFLGN-----------RSVILNHMAREHAFNIGLPDNIVNCNEFLCTLQK--KLDNLQCLYCEKTFRDKNTLKDHPKNREYDRFYVINYLELGKSWEEVQLEDDRELLDHQEDDWSDWEEHPASAVCLFCEKQAETIEKLYV----HMEDAHEFDLLKIKSELGLNFYQQVKLVNFIRRQVHQCRCYGCHVKFKSKADLRTH................................. 363
19 -11.500[D] KOG2186 Cell growth-regulating nucleolar protein  ali follow..  4.................................FQCDDCGENLKKPRLPRHMSM--CTATKFS-----CIDCGNMFGQVSVHY-----HNQCIT-------------------------EAEKYGPMVRSNGESSKQKHDFDINAELFNSQW-----FCSLCNATMTCEQDYFAHVYGKKHQEKANEVADMDYSQQSEHPAVDKNNLTQQPDLDIYVGLSNDYPWFCSLCDINATSEQTLLAHANGKKHRVKVERFDAEQQKRQSTQHSTVDKKDYSKQQIE-WFCSLCNVKATCQQNLLSHAN............................... 244
20 -11.400[C] COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit  ali follow..  45....TEFCVSCHSM----QPVYQEYKQSVHFQ-AECHDCHIPPDIPGMVKRKLEASNDLYQTFIAHSTCRSCHNY-QNPEAARQMKIAAKENQSCIDCHKGIAHQL-PDMSSGFRKQFDELRASASTHNDGDTLYSLDIKPIYAAKGDKEPAGSLLPASEVKVLKRDGDWLQVQIEGWTETDGRQRVLTQLPGKRIFVASIRGDVQQHVKTLEETTVAATNTQ---WSKLQATAWMQKGDMVNDIKPIWAYADSLYNGTCNQCHGAPDKAHFDA--NGW-----------NGMIGFTSLDKREERTLLK--YLQMNASDTTNTPHSDKGEHNE.. 393
21 -10.900[S] KOG4367 Predicted Zn-finger protein  ali follow..  10  5..............................EEELKCPVCGSFYREPIILP--SHNLCQACARNILVQTSPQSHRAAGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLS--------PALAPVPRNSCITCPQCHRSFPKNRVLEGVIDRYQQSKAAALKCQLCAPKEATVMCEQCDVFY------------------CDPCRAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPV------------------CYQC---------LEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAK 289
22 -10.800[R] KOG4377 Zn-finger protein  ali follow..  11  302..................................................................RFNEDCGF-------ERCGYRNHQSHFHCRDCHYSFCDKTRFVQHTARH------------------------ERMDTLMGDDFRQFRANMQCGVASCGYATASGAATETNHLSRIDPTEAVTASSRKTSH--HCRKCDYVCTDSNKVVAHRRLHQDYVRNAGFRKVG------------------------GNEQCDS----PGCSYAQRHTH---YHCVTCDGGVLSRAQLAAHK---------HRTGFPKQEADTTP......... 493
23 -10.800[T] KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains  ali follow..  12  338LESQQWKCAACRQSLHTHNINDREQCPRF------CDYY-------------GLFFCSLCHGGEKSILPARVELPVSDRAQRFLRAVRESPVFRIRDLPGDL----VKKNKALRAVVELRQKLKHMEGFIKICIDASNQVFEFGNLSTMFASIDRYLLEHDDLFSLNDLQRIYNKDLLSLLEPLAKRAREHIIH------CKKCRLQ-----------------PVCVRCNDM---------TDRLF----FEERAVSRCEGCGHL------------SHSPKCPCPKCAR............................................ 575
24 -10.700[R] KOG4684 Uncharacterized conserved protein, contains C4-type Zn-finger  ali follow..  51.................................................................................................................................................................................................SGIPVINCRVCQSLIN------LDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLI-TSRRIGCPRPNCRRIINLGPVMLISEEVVCGHCGNTFLWMEL--------------RFNTLAKCPHCKKICSSSVGSA. 188
25 -10.700[O] KOG1814 Predicted E3 ubiquitin ligase  ali follow..  13  157..................AFDKNAKLLEFQIRKFQCNVCFDEFNGTDCFQLTGHVSCQSCLRDYYTMCCLDCGKDAPVLTLKELESIVGVQLT--NRYKELEEKRRYENDSNIIFCP---------------RSFCQGPSKRDPGQKLAICQKCDFAFCSFCQATWHGDLSPCKLEGDSKKLVEMYLNYQENEPEKALELEKRYGKRIIDRLVEQVKNDEEAEKWVCPTCDRVVERID---------CCH-------MNC-LCGTHF------------------CFLCGAYLMEQNPYKHFNDP.............................. 412
26 -10.600[KL] COG5151 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1  ali follow..  16  224.....................IVGLAAEVAICKEICNKTNSSTKNAYGVVISEQHFRELLLESTIPPATDSAKTTDASLVMMGFPSKVVEQLPSLCACHSIPSRGGFH-------CPRCKAKV------------CTLPIE-----------------CPSCSLVLILSTHLARSYHHLFPLKNWSEIPWSANPK--STHCFACQLPFPKPPVSPFDESTSSMRYACPSCKNHF-------------------------CLDCDVFA------------HEQLHECYGCQCS........................................... 419
27 -10.600[KL] KOG2807 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1  ali follow..  16  224.....................IVGLAAEVAICKEICNKTNSSTKNAYGVVISEQHFRELLLESTIPPATDSAKTTDASLVMMGFPSKVVEQLPSLCACHSIPSRGGFH-------CPRCKAKV------------CTLPIE-----------------CPSCSLVLILSTHLARSYHHLFPLKNWSEIPWSANPK--STHCFACQLPFPKPPVSPFDESTSSMRYACPSCKNHF-------------------------CLDCDVFA------------HEQLHECYGCQCS........................................... 419
28 -10.600[R] KOG1819 FYVE finger-containing proteins  ali follow..  20  569....CEQCTACSMPF-------NFVRRRHH-----CRNC-------------GRIFCHK---------CSCNTISIPEHGYDRKPVV------SSPQSNLSLLTRQ..................................................................................................................................................................................................................................... 630
29 -10.600[O] COG0068 Hydrogenase maturation factor  ali follow..  12  100ITPDAATCPECQREIFDPF------SRFYRYPFTNCTHC-----GPRLSIIRAIPYDRCNTSMSAFVMCPECED----SYHDVENRRFHAQPVACHTCGPKA---WLERADGKPVTAS------MFSMLDDVDAVCTLLQKGEIVAIKGIGFHLAC---EAAVEKLRQRKRRYDKPFALMARDINVIEKYCFVNDRERELLVSPAAPI---VLLEKRTEEISSFPIASTVAPGQNTLGFML----------YTPLHHLILKRMNRPIVLTSGNIADE---PQCVANDEAKEKLSHIADYFLLHNREIVNRVDDSV.................... 377
30 -10.500[R] KOG2785 C2H2-type Zn-finger protein  ali follow..  1..MATYTCITCRVAFRDADMQRAHYKTDWHRYNLRRKVASMAPVTAEGFQERVRAQRAVAEEESKGSYCTVCSKKFASF--NHLKSRRHVELEKKAVQAVNRKVEMMNEKNLEKGLGVDSVDKDAMNAAIQQAIKAQPSMSPKKAPPAPAKEARNVVAVGTGGRGTHDRDPSEKPPRLQWFEQQAKKLAKQQEEDSEEEE-DVVEQDAEEEEAEEGPPLGAIPITDCLFCSHHSSSLMKNVA----HMTKDHSFFIPDIEYLSDI---KGLIKYLGEKVGVICLWCNEKGKSFYSTEAVQAHNDKSHCKLFTDG..................... 337
31 -10.300[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  13  273..............................................................................................................................................................CDFCLGD--------SKINKKTGQPEELVSCSDCGRSGHP----SCLQFTPVMMAAVKTYRW--QCIECKCCN---------------ICGTSENDDQLLFCDDC------------DRGYHMYCWSCHLCLDLLKEKASIYQNQNS.............................. 390
32 -10.100[R] KOG1842 FYVE finger-containing protein  ali follow..  11  2..............IGATGSGGTGGHNDVVRQGFICPFCMEDFGEYERLICH---VENDHPEEDSSDLAGMFVSNVKGFFDKAKRGIQKLDAKKSIADLASNVETEFTETTEKLVERAPLPRIPKPLPPDEILPGTRRSKTREFLSTRELNINEVAVRTNMLIIRLDRLINGGPKDKDPVKRKEFEREVVPWLDDAEAVCCPLCASRF-----GLTRRRHH-----CRLC-------------GRVLCHSCSKFLSSNPLGDTHIIVEE.................................................................. 240
33 -10.100[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali follow..  14  753.............................................................................................................................................................LCIFCG----------ERSESFTEEGLDLHYWKHC----MLTRCDHCKQVVE---ISSLTEHLLTECGKCYRCSEAVFKEELPRHIKHKDCNPAKPEKLANRCPLCHENFSPG-----EEAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKSSAVAASGPLGSKAGSKIPTPKGGLS 915
34 -10.100[O] COG3058 Uncharacterized protein involved in formate dehydrogenase formation  ali follow..  16  190........................................................................................................................................................................................................CPVCGSMPVSSMVQIGTTQ--LRYLHCNLCETEW-------------------HVVRVKCSNCEQSGKLHYWSLDDEQAAIKAESCDDCGTYLK......................................... 263
35 -10.000[L] COG0551 Zn-finger domain associated with topoisomerase type I  ali follow..  10  5............................................................................................IKCPTCGRNMSTGVFLGCTGYALPPKERCKTTINLIPEAELLNVLDESSETKALMDRKR-------CTKCGTAMDSYVIDAHRKIHICGNNPNCDGYLIEEGSFPVVECDKCGADM---HLKLGRFGKYMGCTNCDNTRKILKNGEVAPPKEEP------VHFPELKCEKSDAYF---VLRDGASGVFMSAHNFPKSRETRPVKIAELVQYRERLPEKLAYLADAPQKDPEENEAIVRFSRKE 240
36 -9.910[S] KOG4623 Uncharacterized conserved protein  ali follow..  43........................................................................................................................................................................................................CWFCNGNVR-----------DRNSWTCPSCEQ--KDGDYNRDITSQRDCSLGSQKNSSKGSSSICANSYYSDVLTAQPPAPKNGLCDQCNEAVEKLSQFEPKNESRFDQE-YRERLERLCSSCERHVNKVLHEKK 182
37 -9.890[S] KOG4260 Uncharacterized conserved protein  ali follow..  29.....PPCRACTQLVSSFRAGLERTKRGH-DTAWEEEKLRSYKNSEVRLVEIQEKLCSEGEVIN-KDHCHNLANEIDQLTVCCPLNTYGPDCLTCTECNGNGKCKGDGTRKGNGKCK-CDPGYAGPNCNECGPE------------HYESFRDEKKLLCTQCHAACGEGGCTGGGPKSCRK-------CKKGWSMDSEAGCVDINECLEQQRPNPCRPVNNEGSFSCLECDRS--------------CDGCDGDG-PDMCRKCADGYISAEQRSNYVSFTRMLTYFGMCVAT---------------CVIFQSS--THIAWGCIV.......... 334
38 -9.840[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  18  265......KCPICMDSVSKREPVST--------------KC-------------GHVFCRECIETAITHKCPICNKKLTARQFFRI........................................................................................................................................................................................................................................................... 317
39 -9.830[R] KOG3138 Predicted N-acetyltransferase  ali follow..  15  3........................RPSNWDDPQGPCRYCESPVEDDNYLE------------------CQECRR-------------VHIKCLPHACTPGDLLGDVFFE-----------------------------------------------FTCVKCVL-----------------------------DKAKESVIPSDLE---KEVIVRQRIPWTLTLYNLSIKQKGLGHHGFFHWRTHIFVDKNWNYIFGPRRKQWTGSVSGALSHNSPEYF--------QSGLDVFQENGWW................................... 172
40 -9.790[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  22  193.......CSVCQRGHSPLSNRI-----------VFCDGCNSPY----------HQLC---------------HPPIDDATVQDVDAEWF-----CMKCQYR.......................................................................................................................................................................................................................................... 246
41 -9.750[DR] KOG4739 Uncharacterized protein involved in synaptonemal complex formation  ali follow..  14  1........................................................................................................................................................................................................................................................................................MDWIQCNHCGIKPNQTKLYLTACGHVFCQNCTKAAFNSQCYLCKKPLK....... 48
42 -9.620[O] KOG0826 Predicted E3 ubiquitin ligase involved in peroxisome organization  ali follow..  12  243..................................ECPVCLLSIQTPTACSVSGYVFCWKCIVSHMKGTCPVTHYPISLDDLVRI........................................................................................................................................................................................................................................................... 294
43 -9.530[S] COG4306 Uncharacterized protein conserved in bacteria  ali follow..  12  9.................................................................................................................................................................................................................................ICTNGHVATTAADQKHELWEAFCSHS-GEATILQYPKCSASIRGDDYVEGVLGFGGD--FCNNCGSRFPWAERKIAGTVELV............................ 92
44 -9.520[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  17  20..............................................................................................................................................................................................................................IDKECAVCYSEMILPTTIPSCGHKFCFICLKGVSNGDCPICRGPIDSQIFK.............................................................. 73
45 -9.410[O] KOG1873 Ubiquitin-specific protease  ali follow..  11  44....VKETQACVH-FDKALNLEKVLDKIKSSRQIKCAECNEGVYGKRGTKAKGS-SSDPKSNNKAIWLCLECGCYVCGGVGLPNGPQSHPQLRWCFPCQLLLPVEKEDNGEKKDVLSEVVKLIKGRSLNNLASSDIEDQCSGSGSITSDVNLGNTCFSIMQNLLSLDRLRDHFLKENGSGVGGPLASSLRKLFTETKPE--------------AGLKSVINPRAFFGSFCSKAPQFRGYDQHDSHELLRCLLDSLSTEESALRKKR-STTLIESVFGGETSSIVSCMECGHSSKVYEPFLD.................................. 380
46 -9.320[S] COG4357 Uncharacterized conserved protein  ali follow..  14  15.........................................................................................................................................................................................................SRCVHWHLPKDVIAIRFKCCDKYYACFECHQELSSHPLEKYDLLD-----DANKHLIICGVCRHEMTFAEYYDYNSNLI-----CPNCRSPFNPGCKYFQNPPPAMC........................... 116
47 -9.300[S] KOG3931 Uncharacterized conserved protein  ali follow..  14  584...................................................................SCPICFEKMRRTELSN-----HFD-----GCAIMVRLEPPSFKPKNRRTTASLTSKDSSGASTSRRAKSKAKSSKGILR-----------SSGYTEGEIDKLNLSSSTDSSTLPSSEDELTPRQRRQRNLFKGCPRCGLEIMPLHLKV-----HGS--VC............................................................................................................ 718
48 -9.100[S] COG4847 Uncharacterized protein conserved in archaea  ali follow..  21  1..MAEYKCYVCEKPVKTGEKFTFTKKGSVHYDCFI............................................................................................................................................................................................................................................................................................................ 33

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Ye Y, Li Z, and Godzik A. Modeling and Analyzing Three-Dimensional Structures of Human Disease Proteins Pacific Symposium on Biocomputing 11:439-450(2006) [PDF]