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Query: [U] KOG1162 Predicted small molecule transporter, from COG0516

Results of FFAS03 search in COG0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVKFSKELEAQLIPEWKEAFVNYCLLKKQIKKIKTSRKPKPASHYPIGHHSDFGRSLFDPVRKLARTFSDKLFSNSEKPEILQVRRRRGSSETGDDVDEIYQTELVQLFSEEDEVKVFFARLDEELNKVNQFHKPKETEFLERGEILKKQLETLAELKQILSDRKKRNLSGSNSHRSFSSSVRNSDFSAGSPGELSEIQSETSRTDEIIEALERNGVSFINSATRSKTKGGKPKMSLRVDIPDAVAGAEGGIARSIATAMSVLWEELVNNPRSDFTNWKNIQSAEKKIRSAFVELYRGLGLLKTYSSLNMIAFTKIMKKFDKVAGQNASSTYLKVVKRSQFISSDKVVRLMDEVESIFTKHFANNDRKKAMKFLKPHQTKDSHMVTFFVGLFTGCFISLFVIYIILAHLSGIFTSSDQVSYLETVYPVFSVFALLSLHMFMYGCNLYMWKNTRINYTFIFEFAPNTALRYRDAFLMGTTFMTSVVAAMVIHLILRASGFSASQVDTIPGILLLIFICVLICPFNTFYRPTRFCFIRILRKIVCSPFYKVLMVDFFMGDQLTSQIPLLRHLETTGCYFLAQSFKTHEYNTCKNGRYYREFAYLISFLPYFWRAMQCVRRWWDESNPDHLINMGKYVSAMVAAGVRITYARENNDLWLTMVLVSSVVATIYQLYWDFVKDWGLLNPKSKNPWLRDNLVLRNKNFYYLSIALNLVLRVAWIETIMRFRVSPVQSHLLDFFLASLEVIRRGHWNFYSGELast
1 -190.000[U] KOG1162 Predicted small molecule transporter  ali  100  1MVKFSKELEAQLIPEWKEAFVNYCLLKKQIKKIKTSRKPKPASHYPIGHHSDFGRSLFDPVRKLARTFSDKLFSNSEKPEILQVRRRRGSSETGDDVDEIYQTELVQLFSEEDEVKVFFARLDEELNKVNQFHKPKETEFLERGEILKKQLETLAELKQILSDRKKRNLSGSNSHRSFSSSVRNSDFSAGSPGELSEIQSETSRTDEIIEALERNGVSFINSATRSKTKGGKPKMSLRVDIPDAVAGAEGGIARSIATAMSVLWEELVNNPRSDFTNWKNIQSAEKKIRSAFVELYRGLGLLKTYSSLNMIAFTKIMKKFDKVAGQNASSTYLKVVKRSQFISSDKVVRLMDEVESIFTKHFANNDRKKAMKFLKPHQTKDSHMVTFFVGLFTGCFISLFVIYIILAHLSGIFTSSDQVSYLETVYPVFSVFALLSLHMFMYGCNLYMWKNTRINYTFIFEFAPNTALRYRDAFLMGTTFMTSVVAAMVIHLILRASGFSASQVDTIPGILLLIFICVLICPFNTFYRPTRFCFIRILRKIVCSPFYKVLMVDFFMGDQLTSQIPLLRHLETTGCYFLAQSFKTHEYNTCKNGRYYREFAYLISFLPYFWRAMQCVRRWWDESNPDHLINMGKYVSAMVAAGVRITYARENNDLWLTMVLVSSVVATIYQLYWDFVKDWGLLNPKSKNPWLRDNLVLRNKNFYYLSIALNLVLRVAWIETIMRFRVSPVQSHLLDFFLASLEVIRRGHWNFYSGE 755
2 -94.600[T] COG5409 EXS domain-containing protein  ali follow..  21  1..............................................................................................................................................................................................................................................................................................................................................................................................SANSMRFGLLFGAGLPLAIEAACYY---------NATEQSSYLLQIWGGFFLVIFAFVLFDLDCYVWEKTRVNYMLIFEFNQRKSLNWRQHLEIVGAVFFIFSLFFFLCMRNFFPGF----TIYFPALFLGVVGTFLIAPVIVPYWRMRRYLIIQLIRVFLSGLSTVHFQDFFFADQMVSLTYACGNISLFFCLYKRLWR-----QPQLCNSSHSPLLGFFTTLPGILRVFQCFRRYSDSLKFPHLVNALKYIFNILAQMFLSLWRIHPGLKYRVLYTIFAGVNSLFSYTWDILMDWNLLVRKDGRWQFREHRILKQLWPYIIAMILNFIVRSSFIFYCI-FPNHIQHSSGISFFVTLAEIMRRCMWNILRVE 355
3 -55.900[T] COG5408 SPX domain-containing protein  ali follow..  19  1.MKFGKTFANHRIPEWSSQYVGYKSLKKMIKEITRLQEDIYRAHNKNSYDEG-------------------------------------RPPTKMRDSSNSAQNYLDSPKIQKLLASFFFAVDRDIEKVDTFYNSQYAEYKKRFERLLSSNQFNEIKSTLVVDANKEDAVAQTLLTKDTREMNMLLKGTSQAS-----------------------------------------------------------------------------------RLSYHKDDLIEIQSILAELRKQFRNLKWYAELNKRAFGKILKKLDKKVGTNQQMSTMKRILPLQFANDSLITKDLSLLKTIWEQVTFRINSYERVMRSTSPNANANDNTEFFKII............................................................................................................................................................................................................................................................................................................................................................................ 271
4 -27.100[P] KOG1161 Protein involved in vacuolar polyphosphate accumulation, contains SPX domain  ali follow..  23  1.MLFGVKLANEVYPPWKGSYINYEGLKKFLKEDSVKDGSNDKKAR-----------------------------------------------------------------DDSDESKFVEELDKELEKVYGFQLKKYNNLMERLSHLEKQTDTEAAIK---------------------------------------------------------------------------------------------------------------------------ALDADAFQRVLEELLSESTELDNFKRLNFTGFAKIVKKHDKLYPKYPSVKLLEVRLKELPSHSEEYSPLLYRISFLYNILRSNFNTASEPLASASKFSSIVS.................................................................................................................................................................................................................................................................................................................................................................................... 196
5 -26.100[P] COG5036 SPX domain-containing protein involved in vacuolar polyphosphate accumulation  ali follow..  22  1.MKFGQLLKETLMYEYKYSYVNYDKLKKEIKRRNDQGGWSE-----------------------------------------------------------------------EDESDFVELLEKELDKVYSFQKNKSAEVMERIRFCEEQTDEVVRRLDSDNPPNEND---------------------------------------------------------------------------------------------------------------------AILETELTDIMATVHDLAKFSELNYTAFYKIIKKHDKHTGWILKPVFAARLNAKPFFKEQ-YDLLVVKLSKLYDFVRTRGSPIKGDSAAGGTQQNFVRQTT................................................................................................................................................................................................................................................................................................................................................................................. 197
6 -14.200[O] COG5574 RING-finger-containing E3 ubiquitin ligase  ali follow..  14  1............MPGWGEAAIQYKALKKCIKRFASMFKQLNASNMITTVRSNYASNVPSTPSDSTQQPPTNTLPSVSASSQSVETCETVDEDIDTQTMSSDMSEVQSMEISLNCDHEFFEKLTSELQSVEGLQREQRKILFNAIDILSHEISLIASPNSKKKYKSLYCWRK-------------------------------------------------------------FEIYMDSDIFISCKEADQSHERTPELAERHLKWFDDQVRLAKCLPSSSKHRDRILYA-KFLELNESLLKVASFQQMNKLAVTKIMKKFDKRTSLTAQPLFFQVIESDPLLLVDNASKAICFSLS............................................................................................................................................................................................................................................................................................................................................................................................................... 345
7 -11.700[R] KOG2295 C2H2 Zn-finger protein  ali follow..  180..EYKTDFKRQQLEEWKNKYVDSSQADALIRVLDTCVIKLEGGTDEDLKVLDEKPKDPVVYERKAEQMQSVKEVEKTINSPKEEMSEADPVSTQRKPVRPVNSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGKDKVVETETIDLDKVKDGQPRALHRTSSIFLRNLA-----PSITRSEIEAVCNRFSGYLRVAIADPLVER---ITFMRDVNIKEICWGLNNQRLRDCE-IVNRDLSRRVRPANGITAHKQVVRSDIKLCAKIA..................................................................................................................................................................................................................................................................................................................................................................... 622
8 -10.700[R] KOG0431 Auxilin-like protein and related proteins containing DnaJ domain  ali follow..  557....TREARERAATEAHAKVQRAAVGKATDARERAERAAVQRAHAEARERAAAGARDKAAKAAAEAREKAEKAAAEAKERANAEAREKETRVRAERAAVERAAAEARGRAAAQAKAKQQQENTNDLDSFFSSISRPNSAPRQRTNPLDPFQDSWNKGGSFESSRESLRVPPGQPENLRKTSSVTNIVDDLSSIFGGSAISELPNLVGFKMLMEKLKRDDVPDWNATRGHRSGLQKHLLRKMNVIFKYKENKLRKIGSVIFLFNHHAYPGFQRIGVTLDVEIKRKEGNLRALLSTLQYVL--VSLTDLITAASVKKVYRK-DKVQQKGANLQQKYIAEKVFDMLKEAWNKF--NSEELF............................................................................................................................................................................................................................................................................................................................................................................................................. 924
9 -10.500[S] KOG3850 Predicted membrane protein  ali follow..  89.........PDGAPDPQRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIEQNGPSRQPKDVLRDMQQGLKDVGANVRAGISGFGGGVVEGVKGSLSGLSQATHTAVVSKPREFASLIRNKFGSADNIA----------HLKDPLEDGPPEEAARALSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALYGAPGNLDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQN--EMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQLEGVENANARALLGKFINVILALMAVLLVFVSTI-----------ANFITPLMKTRLRITSTTLLVLVLFLLWKH................................................................................................................................................................................................................................................................................................................ 507
10 -9.770[K] COG5641 GATA Zn-finger-containing transcription factor  ali follow..  132.....KNCLTSTTPLWRRDFLKLHGKTDVIKSRNRKSNTNHAHNLDNFRNQTLIAELKGDCNIESSGRKANRVTSEDKKKKSSQLLMGTSSTAKISKKPKTESKERSDSHLSATKLEVLMSGDCSRPNLKPKLPKQDTAIYQEKLLTFPSYTDVKEYSNSAHQSAFIKERSQFNAASFPLNASHSVTSKTGADSPQLPHLSMLLGSLSSTSISNNGSEIVSNCNNGIASTAATLAPTSSRTTDSNPSEVPNQIRSTMSSPDIISAKRNDPAPLSFHMASINDMLETRLQSSKAPCISKANSQSISNSVSSSDVSGRKFENHPAKDLGDQLSTKLHKEEEIIKLKTRINEL-ELVTDLYRRHINELDGK---RALEERLQRTVKQEGNKGG............................................................................................................................................................................................................................................................................................................................................................................. 551
11 -9.260[S] KOG4740 Uncharacterized conserved protein  ali follow..  8........................................................................................................................................................................................................................................................RLKTSIESTSSDVTVLTDYSSTIPENLPAWTKNTKAQSFGLKSLTALYTLILTIVAFII----EISPTWQSESMNIEYTIFCVLMYSIAILYFI----AYILYPIVFNTILLYLERMRVLNVHTVKRWVQPEPVFTGEGAGTLYLGTVLFGTLGSVLWGCEIFLCFFTETRHNIYVVKYILAFLFTYLQMHFLCAVNLWVWFSLCLADKKTLKLQKAEEKYKKKNMTITEAVAETITTTIASIVSSESSSGFRADEKQLRSLYKLGSAANFLLTTMVEF------------SLIAAAVYFIVWKHE-SVGIFAAIVLLIGSFISIAMHYIYN-NSDMPRTADEVIGIAETVLFCVCLLAVFGAFIRMRKLQYRLHAHGQVVDAGEIVYCSTGLDLYLNGRLENTPGTSCLTVVAFVMRIVQVVVQSVFILVASRLRSLSASNISNQ---PGKQIVTFLVVCNINL---FIYHTFETIESNFGFPALLNISSPLVVFYRFIWHAYSKK 564
12 -9.150[D] COG3096 Uncharacterized protein involved in chromosome partitioning  ali follow..  987.......................EKLRERLEQAEAERTRAREALRGHAAQLSQYNQVLASLKSSYDTKKELLNDLQRELQDIGVRADSGAEERARIRRDELHAQLSNNRSRRNQLEKALTFCEAEMDNLTRKLRKLERDYFEMREQVVTAKAGWCAVMRMVKDNGVERRLHRRELAYLSADDLRSMSDKALGALRLAVADNEHLRDVLRMSEDPKRPERKIQFFVAVYQHLRERIRQDIIRTDDPVEAIEQMEIELSRLTEELTSREQKLAISSRSVANIIRKTIQREQNRIRMLNQGLQNVSFGQVNSVRLNVNVRETHAMLLDSEQHEQHQDLFNSNRLTFSEALAKLYQRLNP--IDMGQRTPQTIGEELLDYRNYLRAESGALSTGEAIGTGMSILVMVV-ISPCRLLFLDEAARLDARSIATLFELCERLQMQLIIAAPENI--PEKGTTYKLV........................................................................................................................................................................................................................................................................................................ 1449
13 -9.060[S] KOG2885 Uncharacterized conserved protein  ali follow..  9LRANSSAFDGALIPKSQEQWKAKKKTKEQSKNDKLKKLDPEQRDDETSSTLEVMKKKEKDAKPVVLPGEKFKHMKMQKQKEATSKVEGDSDLNVEVNDPMIIAPDEDEEEEEDIKVIFDDEGNEIPLESKK--EEEKLQRKKNLEALRSKLQAKISDMKSKRKAPGSREAILAQRKRKEELKKRKRLESEQEQDQDEIASDSDMEDIDSDLENNSKKRFKKGKKDSEINADGVMFQNIIFDDGARATSDLQRLRKAGRTKGPAKNDVKSHLKLLEAKKNKMEAKDELEQIKQKEKEKWQKAMLQAEGIKIRDDEKLLRKAIKRKEAQKRKSAIEWSERKRVVEDTISERQKRREENLRIRKDNKGKKRNKQEKMKRKYVGSA..................................................................................................................................................................................................................................................................................................................................................................................... 412
14 -9.050[K] KOG3248 Transcription factor TCF-4  ali follow..  18LISFKDE-QEEKSSENSSAERDLADVKSSLVNESETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMLPNGSLSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYALTVNASVSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKAFMLYMKEMRVVAECTLKESAAINQILGRRWHALSREEQAKYYELARK------------ERQLHQLYPGWSARDNYGKKKKRKRDKQPGETNEHS................................................................................................................................................................................................................................................................................................................................................................................. 419
15 -9.030[K] KOG4661 Hsp27-ERE-TATA-binding protein/Scaffold attachment factor (SAF-B)  ali follow..  28....TRRLSDDLRADVRKRNVDSSGNKSVLERLKKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQEH-EEPSLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVG.................................................................................................................................................................................................................................................................................................................................................................................... 434

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Friedberg I, Godzik A. Functional differentiation of proteins: implications for structural genomics. Structure. 2007 Apr;15(4):405-15.