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Query: [O] COG5540 RING-finger-containing ubiquitin ligase, from COG0516

Results of FFAS03 search in COG0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSYYQIIVCILASISYIILLEVIALDLGVLDNIFIPKRFAASTDVAIQLPDRNVTLWSRQAVFGKHFTNASATTVINLYLPSNFQEDMSGCPNRNDTDASYFYENDIIDYDIEYIEQKSYSSKPSARVQKDDGGESKDEAILDFLLVQRGKCTYFDKALEAQRLGFKGVIVGDNRSPSSFRLHYMVAPDKVDESKVHIPSLFVSTSSYNLLWSDLLHSYRQPLKLYAKPEELGDMFWPFLLCFSPSIIMLITVQALAIRKFIRTYRTKSKTRRFIEDLPSRTISREGFYSEEEEIENSTQNGELVPLMDESTRRATFGVECVICLESFTKGDKVVALPCKHEFHRPCIAKWIVDYRHACPTCNTEVPPPKPFLast
1 -149.000[O] COG5540 RING-finger-containing ubiquitin ligase  ali  100  1MSYYQIIVCILASISYIILLEVIALDLGVLDNIFIPKRFAASTDVAIQLPDRNVTLWSRQAVFGKHFTNASATTVINLYLPSNFQEDMSGCPNRNDTDASYFYENDIIDYDIEYIEQKSYSSKPSARVQKDDGGESKDEAILDFLLVQRGKCTYFDKALEAQRLGFKGVIVGDNRSPSSFRLHYMVAPDKVDESKVHIPSLFVSTSSYNLLWSDLLHSYRQPLKLYAKPEELGDMFWPFLLCFSPSIIMLITVQALAIRKFIRTYRTKSKTRRFIEDLPSRTISREGFYSEEEEIENSTQNGELVPLMDESTRRATFGVECVICLESFTKGDKVVALPCKHEFHRPCIAKWIVDYRHACPTCNTEVPPPKPF 372
2 -90.700[O] KOG4628 Predicted E3 ubiquitin ligase  ali follow..  18  14......................................................................LCLVCHEATLVGGHVLVYRKATSQLIEEFNDLPAQFGPNLPSNGLKVYVVARRPYYGCDSLDRPPHYPPSAKFVALVARGECVFERKIRVAQNASYSAVIVYNNEGDD------LEQMSAENITGIRIPSVFVGHTTGKALATYFTTEVVLIINDELPFNINTQLILPFSILIGMCFIIMVIYMIYKCIREQRRLRRHRLPKSMLKKLPVLRYT--------------------------KNNANNKYDTCVICLEDFIEDDKLRVLPCSHPYHTHCIDPWLTENRRVCPICKRKVFTKG.. 284
3 -45.900[O] KOG0800 FOG: Predicted E3 ubiquitin ligase  ali follow..  19  25...............................................................................................................................................................................................................................................AFIFSVPICFTFIILFLFYLIYLRRSSSDLSSLGMRTTFIPGNSLSTIELGLSKELREML------PIVVFKESFTVMDSQCSVCLGDYQPNDKLQQIPCKHTFHMDCIDLWLTSH-TTCPLCRLALIPSRS. 150
4 -44.700[O] KOG0801 Predicted E3 ubiquitin ligase  ali follow..  26  149.............................................................................................................................................................................................................................................................................................SKSVASDEMEMHFIMCLSKPRLSYNDDVLTKDAGECVICLEELLQGDTIARLPCLCIYHKSCIDSWFEVNR-SCPEHPAD....... 227
5 -44.000[R] KOG2442 Uncharacterized conserved protein, contains PA domain  ali follow..  14  19.............................................LIGLLCVGADTKDVTAPKIPGCSNEFQMVKV-----------ENWVNGENGETFTAMTAQFGTMLPSDKDKAVVALTTPLDSCSNLTSKLSWS-----IALSVRGECAFTVKAQVAQAGGAAALVLINDKEE----LDEMVCGEKDTSLNVSIPILMITTSSGDALKKSIMQNKKVELLLYAPKSPIVDYAVVFLWLMSVGTVFVASVWSHVTSPKKNDEQYDELSPKKSSNVD--------------------------ATKGGAEEETLDISAMGAVIFVISASTFLVLLFFFMSSWFILILTIFFVIGGMQGICMM........ 294
6 -36.400[O] KOG3970 Predicted E3 ubiquitin ligase  ali follow..  28  45........................................................................................................................................................................................................................................................................................................................TDQDYDPNCSLCKTTLAEGDTIR-LNCLHLLHWKCFDEWAANFPARCPCCSQEVFPPIN. 109
7 -35.200[R] KOG3920 Uncharacterized conserved protein, contains PA domain  ali follow..  13  1.......................................................MVPGAAGWCCLVLWLPACVAAHGFRIHDYLYFQVLSPGDIRYIFTATPAKFGGIFHTRYEQIHLVPAEPPEACGELSN---GFFIQDQIALVERGGCSFLSKTRVVQEHGGRAVIISDNAVDNDSFYVEMI--QDSTQRTADIPALFLLGRDGYMIRRSLEQHGLPWAIISIP................................................................................................................................................ 169
8 -32.700[O] KOG1734 Predicted RING-containing E3 ubiquitin ligase  ali follow..  16  210..........................................................................................................................................................................................................................................LFLHKLSYVLGVVGYLIMMGALLGFHVLFGVSQPTLMDAGILFMFYGVYYGVLGRDFAHICTARMASRIGYYTPEGLPKKHLEDGVCAVCGGRLDEDEKLYKLSCGHVFHEFCIRGWVVGKLQTCPYCKERVDLQR.. 365
9 -30.500[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  21  229...........................................................................................................................................................................................................................................................................................LPRRSAENDPVVDLDVASPPKRVNRDIDESQKEELYKCPICMDSVSKREPV-STKCGHVFCRECIETAI-RATHKCPICNKKLTARQRI 317
10 -28.700[O] KOG0827 Predicted E3 ubiquitin ligase  ali follow..  38  5...............................................................................................................................................................................................................................................................................................................................NCVICAELFGQADEVFATVCGHMFHHNCLNQWL-DRSKTCPQCRNKCTTRN.. 54
11 -28.100[O] KOG0828 Predicted E3 ubiquitin ligase  ali follow..  10  399HLLFGIALFAAQIYLLLTQMHHTNTPSMVNKISFYCFSMINLVDGSLATLYFVAASVVPELYLPLVISAFSCFILASIFEIRYLISIYASQVNEQNVGIINLLRGNTGTYDENRPRPAFIPDEGSIGGSLYGRFFFMLIIFTFLILSS----VFEYILIFILNSYWIPQIFRNAVKGIPSRRERARSSIGGNRSQNK-MPLLWSFVIGTTIIRSL-----PVVYVFTYSSNVFRHHKDVHFVVFLSLWLLFQISILYSQDVLGSRWFLP-------------------KHTIPDGYSYFKPLSNEYISEHGGGTAEHTVDCAICMSTHKVDQHSYMVPCNHVFHTSCLENWM-NYKLQCPVCRSPL---PPL 758
12 -28.100[S] KOG4445 Uncharacterized conserved protein, contains RWD domain  ali follow..  13  1...................................................................................................................................................................................MDDVCIKRTPSGEVEQIETT---VLPLTGEE-----EEQQYVCVTLQVHPTPGYPEESPTFKLL----------------------RPRGLDDARLEAI-----RSACNAKIKESIGFPVVFDLIEVVREHLSGSNLPSGQCVVCLYGFADGDEFTRTECFHYLHSYCLARHLNALRRLCPVCREHIGDETD. 179
13 -28.100[O] KOG0802 E3 ubiquitin ligase  ali follow..  15  279..............................................................................................................................................................................................................................................NLGFFLDMATLVMALGHYLHIWWLHGIAFHLVDAVLFLNIRALLSAILKRIKGYIKLRIALGALHAALPDATSEELRAYDDECAICREPMAKA---KRLHCNHLFHLGCLRSWLLNEVYSCPTCRKPLFVGRT. 411
14 -26.200[O] COG5243 HRD ubiquitin ligase complex, ER membrane component  ali follow..  15  269...................................................................................................................................................................................................................................................MYEKAIDVFTRFLKTALHLSMLIPFRMPMMLLKDV-LALYQSGTSLWKIWRNNKQLDDTLVTVTVEQLQNSANDDNICIICMDELIKNKKPKRLPCGHILHLSCLKNWM-ERSQTCPICRLPVFDEKG. 408
15 -25.800[O] KOG4265 Predicted E3 ubiquitin ligase  ali follow..  10  92...................................................................................................................KDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETV-HYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVSYLLQEI------------------YGIENKNNQETKPSDDENSDNSNECVVCLSDLR--DTL-ILPCRHL--TSCADT-LRYQANNCPICRLFPGP.... 322
16 -25.800[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  74.................................................................................................................................................................................................................................................................................................LDSPVRVSQNESEGIENQNRRMSNGNKVTLRDCLVLSVWKFGPAVANTKSGILDSIVFPVDTCMDIPSGFSSDEVEGSLRD.. 157
17 -25.300[O] KOG3268 Predicted E3 ubiquitin ligase  ali follow..  14  185....................................................................................................................................................................................................SIYSQFLAAESLKAFWDVMDEIDEKTWVLEPEKPPRSATARRIALGNNVSINIEVDPRHPTMLPECFFLGADHVVKPLGIKLSRNIHLWDPENSVLQNLKDVLE---IDFPARAILEKSDFTMDCGICYAYQLDGT----IPCGQPFHQICLYEWLRGLLTECPYCSKPITLKMS. 371
18 -24.900[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  17  3...........................................................................................................................................................................................................................................................................................................ASTSSPSQQLQQAINSTIDKECAVCYSEMI--LPTTIPSCGHKFCFICLKGVSVSNNGDCPICRGPIDSQ... 70
19 -24.600[O] KOG3800 Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor  ali follow..  19  1..............................................................................................................................................................................................................................................................................................................................KECKKCKSNEYTNKQLVMMECGHPLCKNCVDNIFALNSGNCHVCNRVLRKNN.. 54
20 -24.600[DO] KOG1493 Anaphase-promoting complex (APC), subunit 11  ali follow..  35  66..........................................................................................................................................................................................................................................................................................................................QGGEDTCGICRMEFESDDCPLVLGCRHAFHRHCIDKWIAAPRAQCPLCRQDWTIVE.. 135
21 -24.600[O] KOG0823 Predicted E3 ubiquitin ligase  ali follow..  23  79...........................................................................................................................................................................................................................................................................................HERSRERLVENGENKTYLIAKALNMEKTSSVPGGFFDCNICLEKAE--DPI-LTCCGHLFCWGCFYQLP-LNIKECPVCDGEVTDAEPI 168
22 -24.200[O] KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein  ali follow..  11  122.................................................................................................................................................FITKLYKKIMKNNKESKIEDTESVAAFCKGLLDFILDVHM--------------TLFYFKGAFYSISKRIFGMRYVFKHILSKNEANFREEGSQKYKVLGYILLAQNVMKWYPVLTSTLGSWIYGRKRTNDSITRSSVGLQERSEHESIEGIPKESQLTHINLSDKNQLPEASRKCILCLMNMSD-----CAPCGHLFCWSCLMSWC-KERPECPLCRQHCQPQEVL 335
23 -23.800[O] COG5574 RING-finger-containing E3 ubiquitin ligase  ali follow..  27  359...............................................................................................................................................................................................................................................................................................................................ECAICSNVA---KPVR-LGCSHVFCLHCLIILQKQKVDFCPLCRAKEVMKA.. 406
24 -23.400[R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers  ali follow..  17  222................................................................................................................................................................................................................................................................................................REWDSVQEKYKKGAKLEEGMVKNEKKEDIPFVCLICKKDYRSP----ATTCGHHFCEQCAITRYRKTPT-CIQCGADT...... 295
25 -23.000[R] KOG4299 PHD Zn-finger protein  ali follow..  14  208......................................................................................................................................................................................................................................................................EVVTENNVTRNVTVYSNQKHLGNESENFNDMEGRAEDISSNELLPTPEEYPYRYNNDYCSAC----GPGNFLCCETCPNSFHFTCIDPWY------CNECKHHSLYNE.. 317
26 -22.600[OD] COG5194 Component of SCF ubiquitin ligase and anaphase-promoting complex  ali follow..  37  68...............................................................................................................................................................................................................................................................................................................................ECQPKAMTDTDNECVAAWGCNHAFHLHCINKWI-KTRDACPLDNQPWQLAR.. 118
27 -21.800[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  10  28................................................................................................................KRTAKVLKAAPQYNIDGDLKSVVERQRDKKIPYAVIRGTVTPIGVPLRSSLVPSVSGVLQIVKLHEHRVTRGFAGFWTEQHKLLEMPFELRNQSHGVEIVDALSAAVLDVDVVYDNYEPSNLSLFPLFLTTATKSTLIKRFEDAKTTTILKLVVCSTISAILVAFIAKKLYRKRKQEREEAKIRERLDTERRERRARSRPHTLSQDQLCVVCSTNPKE---IILLPCGHV--EDCAQ----KISVTCPVCRGSIVSKAAA 335
28 -21.400[T] COG5432 RING-finger-containing E3 ubiquitin ligase  ali follow..  25  23...........................................................................................................................................................................................................................................................................................................................DTLLRCHICKDFLKV-----LTPCGHTFCSLCIRTHL-NNQPNCPLCLFEFRESL.. 73
29 -21.400[L] KOG0287 Postreplication repair protein RAD18  ali follow..  25  23...........................................................................................................................................................................................................................................................................................................................DTLLRCHICKDFLKV-----LTPCGHTFCSLCIRTHL-NNQPNCPLCLFEFRESL.. 73
30 -21.300[O] KOG1813 Predicted E3 ubiquitin ligase  ali follow..  23  241............................................................................................................................................................................................................................................................................................EEAEKVRKRNKAMGVEDEDDEADKDSDEDENALPFACFICREPFV--DPV-VTKCKHYFCEHCALKHH-TKNKKCFVCNQPT...... 318
31 -20.600[O] KOG0826 Predicted E3 ubiquitin ligase involved in peroxisome organization  ali follow..  10  72..................................................................................................................................................LRKRASSFGESFYGLQRTVTTTGDLLNRRQQFASATLLTFMPYVER----KLRTRITRHEDTSPWEQRLLSAFHAFHAAKA-------HTFFYLVKYASNHSPIFRLLGLTLRYPSEPPKEDQWTYVVLKMLEVLAWYSNDQRRKVGGTLINPEAMPRKQLPKEVQQSLPQRGECPVCLLSIQTPTAC--SVSGYVFCWKCIVSHM-KEHGTCPVTHYPISLDD.. 290
32 -20.300[O] KOG2930 SCF ubiquitin ligase, Rbx1 component  ali follow..  37  55...............................................................................................................................................................................................................................................................................................................................ECQANQASATSEECTVAWGCNHAFHFHCISRWL-KTRQVCPLDNREWDFQK.. 105
33 -19.400[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  18  780......................................................................................................................................................................................................................................................................SSEKEYEQISRRTDDIKLELDDEREKKKLEEELMELNKELEELGSESVEAAIVRLQEECGVCFDRPKE---VVIVKCYHLFCQQCIQRSLEIRHRKCPGCGTAFGQND.. 893
34 -19.300[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  12  161................................................................................................................................................................................................................................................................................................TKSGRKIQRPVAYNPNATALKRKSRKVDMVTLCSVCQRGHSPLSNRIVF-CNSPYHQLCHHPWF------CMKCQYR....... 246
35 -19.200[DR] KOG4739 Uncharacterized protein involved in synaptonemal complex formation  ali follow..  21  6................................................................................................................................................................................................................................................................................................................................CNHCGIKPN-QTKLYLTACGHVFCQNCTKA---AFNSQCYLCKKPL...... 47
36 -18.700[DKL] COG5220 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3  ali follow..  16  2.....................................................................................................................................................................................................................................................................................................................DDEGARKVDEKCPLCQADRYLNPNMKLLECYHKMCESCVDRIFTTGPAQTPGCNKILRKAK.. 67
37 -18.600[R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  13  253...........................................................................................................................................................................................................................................................................................DKQSWEDYQRKRENRQIDGDETIWRKGHFKDLPDDLKCPLTGGLLR--QPVKTSKCNIDFSKEALENALVESDFVCPNCETRDILLDSL 340
38 -18.400[R] COG5219 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  11 1414................................................................................................................................................SSVRSYWSEVKNRVESFTGYNVSPLLISASLDDVERSIESEDFQSVGD-------NVKVNRNTREISFIYNVDEHKLEMAIKIPSV-----------------------------YPLQNVQVEGIERVGVNERQWRSWILASQSILSSQNGSITDALLV---KKNISMHFEGVEECAICYSVLSVERT---LPCRHKFHASCLYKWFSSNSSRCPLCRSSF...... 1607
39 -18.300[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  20  310...............................................................................................................................................................................................................................................................................................................TPVMMAAVKTYRWQCIECKCCNICGTSENDDQLLDCDRGYHMYCLTPW------SCHLCL......... 375
40 -18.000[O] KOG1100 Predicted E3 ubiquitin ligase  ali follow..  10  100........................................................................................................................SREESVVLNPSAYMQIQKNPTDPLMFLGQ---DLSSNVQQ-HHFDIDRLISNHVERMRMEIEEKRKTQGRRIVEAVEQGLMKTLRAKDDEINHIGKLNLFLEEKVKSLCVENQIW----------DVAQSNEATVNALRSNLQQVLAAVERNRWEEPPTVADDAQSCCGSNDEGDSEEERWKLAGEAQDTKKMCRVGMSMCRSCGKG-----SVLLLPCRHM--SVC------SSLNTCPICKSPKTAS... 328
41 -18.000[O] KOG2164 Predicted E3 ubiquitin ligase  ali follow..  15  198................................................................................................................................................................................................................................................................................................................EDVWQVLCSSDFQLAACPFCLEEKPVAA--RMSRCGHVYCFSCLLRFVECGHRSCPICWDSIRLRD.. 280
42 -18.000[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  14  605................................................................................................................................................................................................................................................................................KQLKEVLMLHRVDYKGCCEKQELLDRVSRLWKTMRECPAVEKLATDELCKICMDA--PIECV-FLECGHM--ATCTS--CGKVLNECPICRQYIVR.... 693
43 -17.400[S] KOG4638 Uncharacterized conserved protein  ali follow..  145.........................................................................................................................................EQILPFSLLL---------VFIRQHLQGFFVAIWIAAVMFKSNDILKKQTALKGERHISALIGISVAFTAHVVGVYWWFRKDDLLYPLIMLPPKSIPPFWHAIFIIVYPGSFGAYSLVPIFLRYTCPAGLNDFQGQLLTLVEYFM-NEIQVQSFFTALKALSRKEVHYGSYATTEQATCVPSARRRCTPQFFFAANT-AFQSGEVFLHIAIIFYLDVER................ 412
44 -17.400[O] KOG4692 Predicted E3 ubiquitin ligase  ali follow..  14  418...........................................................................................................................................................................................................................................................................RIRADPPILKFALNDFPSHVSSEEIDNVRRLIDSLRVKQTLLSDITLPSEDSLCPICCAKPIT---AVFTPCKHQSCSDCIMQHMMN-SKVCFYCKTTIQTIETL 518
45 -16.900[S] KOG2660 Locus-specific chromosome binding proteins  ali follow..  28  15...............................................................................................................................................................................................................................................................................................................................SCSICDNILRD---------ATTISEKCIEKITEDEIETCPVCNIDL...... 53
46 -16.700[O] KOG2879 Predicted E3 ubiquitin ligase  ali follow..  12  121................................................................................................................................KGLEGPGLTSPQKIWYCVASVGGQYLFSRLQSFSAFRRWGDSEQRPLARRLWTLVQRIEGIYKAASFLNL-LSFLYTGRYRNLIEKALKARLVYRSPHMNRSVSFEYMNRQLVWNEFSVGLLYPSIDQNILFRLATRNVMLGSDFLVLFWHSALNLFGDIQELPLLNSSAVKNILSPFAKDKSSSTKEDTVTCPICQVDPAIPFIALKELTCRRYCYYCIRTRCASAASRCLRCNEPVVAIQRE 383
47 -16.300[U] KOG3799 Rab3 effector RIM1 and related proteins, contain Rab3a binding domain  ali follow..  13  30..........................................................................................................................................................................................................................................................AIKRVFK-----RQKDEEAKETQISQKA-------------SEELSELDKQITERKETSKKLVGTQDDAICQICQKTFADGIGHKCFYCQLRSCARC---WA------CSLCRQQILAKT.. 136
48 -16.200[B] KOG4718 Non-SMC (structural maintenance of chromosomes) element 1 protein (NSE1)  ali follow..  14  11................................................................................................................................................LLMTHGVLE-EWDVKRLQTHCYKVH---RSATVDKLEDFINNINSVLESLYIEIKRG-VTEDDGRPIYALVNLATTSISKMATDFAENELDLFRKALELIIDSETGFASSTNILNLVDQLKGKKMRKKEAEQVLQKFVQNKWLIEKEGEFTLHGRAILEMEQYIRETYP--DAVKICNICHSLLIQGQSCE--TCGIRMHLPCVAKYFSNAEPRCPHCNDYWPHEIP. 230
49 -15.900[B] KOG1973 Chromatin remodeling protein, contains PHD Zn-finger  ali follow..  16  241...........................................................................................................................................................................................................................................................................................QKKTVEVDDSEKESCHTAATHPSDVMDMPVDPNEPTYC-LC-HQVSYGE---MIGCDNPFHFACVGKWF------CPKCTQDRKKK... 328
50 -15.900[R] KOG2979 Protein involved in DNA repair  ali follow..  10  86..........................................................................................................................................................EGAIDMASASSSDGVAIQNASLVLVSDNSSTLADIRKAVAMMKNIAVQLEKENQTDKVKDLENSVAELLDLHSDCNHRST-------------------AIQSVANRYQPVEQLTDFKKLLDDEFTKLKATPSSVPQNDHLMRQFREAVWNVHHAGEPMPGDDDEDCPLSVTELA--DPVRSMDCRHVYEKSVILHYIVNNPNACPVCRGKLQNSK.. 302
51 -15.400[L] COG5627 DNA repair protein MMS21  ali follow..  12  129.....................................................................................................................................................................................................................................................................IQEYEEKSDYGKYGTQGEYIEFKKTIWHEQNTDGSDFPSMKTFFNVMNTEEQEADE--RCPLTLQPIV--HPILSTACNHFYEKDAILSLL-NPTCVCPVCEARLQRSL.. 244
52 -15.400[B] COG5034 Chromatin remodeling protein, contains PhD zinc finger  ali follow..  17  214...........................................................................................................................................................................................................................................................................................RPVRRSESRLKQTNGEPLVKHDTLDSSDISREGEQLYC-YC-QQVSYGQ---MIGCDNEFHLPCVGIWY------CKECEELAKSSE.. 302
53 -14.800[U] KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11  ali follow..  15  678........................................................................................................................................................DVDLAVILCEMNSFKDGLLYLYEKMKFYKEVIACYMQNHDHEGLIACCKRLGDSSKGGDPSLWAD----LLKYFGEIGEDCTKEVKEVLTYIERDDILPPIIVLQTLAKNPCLTLSVIKDYIARKLEQESKIIEEDRRAVEKYQETTKNMRKEIEDLRTNARIFQLSKCTACTFTLDI--PAVHFMCMHSFHQRC----LGDNEKECPECAPE....... 880
54 -14.700[O] KOG1814 Predicted E3 ubiquitin ligase  ali follow..  10  4................................................................................................................................VEVESDNKHLVADELIAL----QSIYPEIHLDGNNYGRLNILSFKSPDESTLTDTIVVRHFPDLVMEFFLPEAYPFNSPPTFFLKSSWLPLKQKRVLTSSLIKLWNEIHDCVLFDAI---------------------------EHVRSIATIAFHLPTEMVFPGGFDDLKKEILAFDKNAKLLEFQIRKFQCNVCFDEFNGTDCFQLTRCGHVSCQSCLRDYYTMSQIKCI-CGKDAPVLTL. 233
55 -14.500[R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein)  ali follow..  14  137......................................................................................................................................................................EGIMFYKYNDEKLTK--------VAQCRMLCMYAV--AQVEVREIISFMCISLPMIVSIKVVRDPAPNQYMLII-----------------------KFKEHNDAVTFYEEFNNCPFNDLESYCCTLFFVDRIECTTSNDLFSSDDTSLTELPTCAVCLERMDDS--VLAILCNHSFHARCLEQW---ADNTCPVCR......... 297
56 -14.300[S] KOG3899 Uncharacterized conserved protein  ali follow..  150.........................................................................................................................................ITPGSYSAVASEIGIEFRQPEIYKKKLNSISSVIATQNWIIKTTMYNVHFAHQSNT------SLSVAKAETYNISHQDQNDTLQMISIIVRPMRQGVSDFHIRINAL---------------------------RNLENRVRRPIAIPSNIQLHRNVIDRFVDVFKAQVAQNPIFPDDATTEKCFACMLN-ANGACCSNCYCRPMWCVECLARWFAARKCTCPMCRAKF...... 378
57 -13.800[R] KOG3002 Zn finger protein  ali follow..  17  1........................................................................................................................................................................................................................................................................MAPGGSALKEALESNSTGVDYEVKMAKVEANSKPTKSGSGSIGKFHSSNGVYELLECPVCTNLMYP-----IHQCPHTLCSSC----KLRVQNTCPTCRYEL...... 96
58 -13.700[O] KOG1815 Predicted E3 ubiquitin ligase  ali follow..  19  94.....................................................................................................................................................................................................................................................................................LRHFHWSVGRVHDEWFADEERVRKTVGILESHVVPPSDDSELTCGICFDSY-PPEKIASVSCGHPFCTTCIEDMILANSKPCPRCKRPIEKNQ.. 259
59 -13.300[DR] KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins  ali follow..  20  541..................................................................................................................................................................................................................................................................................................VDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDK-----SVVFIPCGHLV--VCQE--CAPSLRKCPICRGII...... 609
60 -12.900[O] KOG1039 Predicted E3 ubiquitin ligase  ali follow..  13  20.............................................................................................................................SQC-LFSHDLANSKPSTICKYYQKGYCAYGTRCRYDHTRPSAAAGGAVGTMAHSVPSPAFHSPHPPSEVTASIVKTNSHEPGKREKRTLVLRDRNLSGMAERKTQPSMVSNPGSCSDPQPSPEMKPHSYLDAIRSGLDDVEASSSYSNEQQEICRLQVLHPFDPEQRKAHEKICMLTFEHEMEKAFAFQASQDKVCSICMEVILEK-RFGILSCNHTYCLSCIRQWRCAKQKSCPECRVISEFVIP. 300
61 -12.900[R] COG5236 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  15  1.................................................................................................................................................................................................................................................................MSESVKENVTPTRNFRRTQGPQNNTKPHNDRKNFRRKQKKNNLSAEPNLTTSSADDTDEENELCVICARKL---TYVSLTPCHHKTCHICG---ALYNKKSCLICRTENEE.... 109
62 -12.400[KL] COG5151 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1  ali follow..  11  79................................................................TPLQRGIIRHMVLVLDLSNSMEERDFHHKRFDLQIKYASEFVLEFFEQNPISQLSIIGVMDGIAHRIT--DLHGNPQSHIQKLKSGNFSLQNALEMARASGTREVLIIFGSILSSDPGDIFKTIDALVHDSIRVRIVGLAAEVAKEICNKTNSSTKNAYGVVISEQHFRELLLESTIPPATDSAKTTDASLVMMGFPSKVVEQLPS-KAKVCTLPIECPSCSLVLILSTHLARSYHHLPLKNWSEIPWSANPKSTHCFACQLPFTSSMRYACPSCKNHFCLDC-DVFAHEQLHECYGCQCS....... 419
63 -12.400[KL] KOG2807 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1  ali follow..  11  79................................................................TPLQRGIIRHMVLVLDLSNSMEERDFHHKRFDLQIKYASEFVLEFFEQNPISQLSIIGVMDGIAHRIT--DLHGNPQSHIQKLKSGNFSLQNALEMARASGTREVLIIFGSILSSDPGDIFKTIDALVHDSIRVRIVGLAAEVAKEICNKTNSSTKNAYGVVISEQHFRELLLESTIPPATDSAKTTDASLVMMGFPSKVVEQLPS-KAKVCTLPIECPSCSLVLILSTHLARSYHHLPLKNWSEIPWSANPKSTHCFACQLPFTSSMRYACPSCKNHFCLDC-DVFAHEQLHECYGCQCS....... 419
64 -12.300[O] KOG2231 Predicted E3 ubiquitin ligase  ali follow..  13  1.................................................................................................................................................................................................................................................................................MQNGKPRSSARPSFHRRPKDGVANTTTDNAAVKPEALESYTGNDDNACVVCFKNV---EIFSIGDCDHPVCYECS---VLCQQNECPICRHVLSK.... 93
65 -12.300[O] COG3058 Uncharacterized protein involved in formate dehydrogenase formation  ali follow..  10  9................................................................................................................................DELGSSEKRTADMIPPLLFPRLKNLYNRRAERLRELA----------ENNPLGDYLRFAALIAHAQEVVLYDHPLEMDLTARIKEASAQGKPPLDIHVLPRDKHWQKLLMALIAELKPEMSGPALAVIENLEKASTQELEDMASALFAS-DFSSVSSDKAPFIWAALSLYWAQMANLIPGKARAEYGEQRQYCPVCVQIGTTQGL-RYLHCN------CETEWHVV-RVKCSNCEQS....... 235
66 -12.200[O] KOG4185 Predicted E3 ubiquitin ligase  ali follow..  25  2............................................................................................................................................................................................................................................................................................................................SFIDCEICDEEFSTLTDVNILRCGHTTCHGCAEKLLRNSTILCPFCREATNVSA.. 58
67 -12.200[U] KOG2066 Vacuolar assembly/sorting protein VPS41  ali follow..  515......................................................................................................................LMNINSERALRLLLDNADSVEPSFVMEKIGRQP-AYLTKLMSRNEG--KAVQLYAEYDQKKLLPFLRKNANYNVNKARKLETIYLLAKSGDAVKMMVREYRNMEKVIDYCKDQNDPDLWIHLLGVVAEFPAHFSQLI-IMDKLPDDSDIPNLSEALDKLLVDYTNHAELQQCCYDSTLNDLNVLTQGLISAADESV-NIVSRCSLCAQIIKKFSDIKVFKCGHIFHLACSERRQSIEEGLCIACSDQIELIN.. 806
68 -11.900[K] KOG2068 MOT2 transcription factor  ali follow..  24  2.........................................................................................................................................................................................................................................................................................................................SDYGEKTCPLCAEEMDLTDQ-QLKPCKCGYQ--CVWCW-DQSEGRCPACRTPYDKEK.. 64
69 -11.800[O] KOG4159 Predicted E3 ubiquitin ligase  ali follow..  27  1.............................................................................................................................................................................................................................................................................................................................................MRLFPCGHSFCKNCLERCL-DHAPYCPLCKESL...... 38
70 -11.800[O] KOG4172 Predicted E3 ubiquitin ligase  ali follow..  21  1.....................................................................................................................................................................................................................................................................................................................NGAQEVNEGDECTICMDAPVNS----LYTCGHM--FECGRR-LLTTKGTCPICRAPVQD.... 56
71 -11.100[O] KOG0006 E3 ubiquitin-protein ligase (Parkin protein)  ali follow..  5.............................................................................................................VRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVP-LRVIFAGNCDLDQQIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAG---SPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQA-------------------TLTLTQEFFFKCGAHPTSDKETPVALHLIATNSRNITCITCTDV-RSPVLVFQCNSRHVICLDCFHLYCVTRGVLCP-CGAGLLPEP.. 317
72 -11.000[R] COG4245 Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain  ali follow..  6.............................................IFFVLDCSESMIGEN----KKMNDGLQMIINDLKKDPHALETAWISVAKTIVPLVEVVSFYPPRLPIGGGTALQELTRQIDTQVRKTTEERKGDWKPVVYLLTDGRPT-RWKTHYARKVNLIAIGLGPSADLNILRQLTENVLLFNDTQEGDFTQFIKWITASVSAHSRSVGEESPPLLNQTDYIVKLAKDDVARAYDENCVTLIGRCSKSRRPYIIKYERPAVNLSSLNFKLNINGFNLAGCLPIDEDYFA-----------SDESVSSQQVNTSDCMAHLVA----HIAATAVHLP---CVT----AVNCSVSMARMML...... 319
73 -11.000[U] KOG2034 Vacuolar sorting protein PEP3/VPS18  ali follow..  10  697...............................................................................................................................................VHIYSMMS-MHEEAVALALQIDPELAMAEDDEDLRKKLWLMVAKHVVKQEKG-------AKRENIRKAIAFLKETDG---------------------LLKIEDILPFFPDFALI---------DDFKEAICSSLEDYNKQIEQLKEEMNDATRGADNIRNDISALTQRYA-DRDEECGVC-SSAGPLAPFYVFPCGHSFHAQCLITHVTS-ASECPFCGELMINTLPF 964
74 -10.900[S] KOG4791 Uncharacterized conserved protein  ali follow..  28  2..........................................................................................................................................................................................................................................................................................................................PNQGEDCSTC----TKGDS-----CP--FHCEC---WQ---EGRCRVCR......... 51
75 -10.900[A] COG5183 Protein involved in mRNA turnover and stability  ali follow..  18  1..........................................................................................................................................................................................................................................................................................MDVDSDVNVSRLRDELHKVANEETDTATFNDDAPSGATCRICRGEATEDNPL-FHPCKKYMHESCLLEWVASKNIKCDICHYNMPEKIPF 113

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Friedberg I, Godzik A. Functional differentiation of proteins: implications for structural genomics. Structure. 2007 Apr;15(4):405-15.