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Query: [O] COG5540 RING-finger-containing ubiquitin ligase, from COG0312

Results of FFAS03 search in COG0312
Master-slave alignment does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSYYQIIVCILASISYIILLEVIALDLGVLDNIFIPKRFAASTDVAIQLPDRNVTLWSRQAVFGKHFTNASATTVINLYLPSNFQEDMSGCPNRNDTDASYFYENDIIDYDIEYIEQKSYSSKPSARVQKDDGGESKDEAILDFLLVQRGKCTYFDKALEAQRLGFKGVIVGDNRSPSSFRLHYMVAPDKVDESKVHIPSLFVSTSSYNLLWSDLLHSYRQPLKLYAKPEELGDMFWPFLLCFSPSIIMLITVQALAIRKFIRTYRTKSKTRRFIEDLPSRTISREGFYSEEEEIENSTQNGELVPLMDESTRRATFGVECVICLESFTKGDKVVALPCKHEFHRPCIAKWIVDYRHACPTCNTEVPPPKPFLast
1 -139.000[O] COG5540 RING-finger-containing ubiquitin ligase  ali  100  1MSYYQIIVCILASISYIILLEVIALDLGVLDNIFIPKRFAASTDVAIQLPDRNVTLWSRQAVFGKHFTNASATTVINLYLPSNFQEDMSGCPNRNDTDASYFYENDIIDYDIEYIEQKSYSSKPSARVQKDDGGESKDEAILDFLLVQRGKCTYFDKALEAQRLGFKGVIVGDNRSPSSFRLHYMVAPDKVDESKVHIPSLFVSTSSYNLLWSDLLHSYRQPLKLYAKPEELGDMFWPFLLCFSPSIIMLITVQALAIRKFIRTYRTKSKTRRFIEDLPSRTISREGFYSEEEEIENSTQNGELVPLMDESTRRATFGVECVICLESFTKGDKVVALPCKHEFHRPCIAKWIVDYRHACPTCNTEVPPPKPF 372
2 -66.900[O] KOG4628 Predicted E3 ubiquitin ligase  ali follow..  17  1...................MSKRSCQILTLLGLCLVCHEATLVGGHVLVYRKAEEFNDLPAQFGPNLPSNGLKVYV------------------------------------------VPARRPYYGCDSLDRPPHYPPSAKFVALVARGECVFERKIRVAQNASYSAVIVYNNEGDDLEQM------SAENITGIRIPSVFVGHTTGKALATYFTTEVVLIINDELPFNINTQLILPFSILIGMCFIIMVIYMIYKCIR---------------------------EQRRLRRHRLPKSMLKKLPVLRYTKNNNNKYDTCVICLEDFIEDDKLRVLPCSHPYHTHCIDPWLTENRRVCPICKRKVFTKGE. 285
3 -55.600[O] KOG0800 FOG: Predicted E3 ubiquitin ligase  ali follow..  21  22............................................................................................................................................................................................................................................LYQAFIFSVPICFTFIILFLFYLIYLRRSSSDLSSLGMRTT------FIPGNSLSTIELGLSKELREMLPIVVFKESFTVMDSQCSVCLGDYQPNDKLQQIPCKHTFHMDCIDLWLTSH-TTCPLCRLALIPSR.. 149
4 -45.100[O] KOG0801 Predicted E3 ubiquitin ligase  ali follow..  27  149................................................................................................................................................................................................................................................................................................SKSVASDEMEMHFIMCLSKPRLSYNDTKDAGECVICLEELLQGDTIARLPCLCIYHKSCIDSWFEVNR-SCPEHPAD....... 227
5 -41.900[O] KOG1734 Predicted RING-containing E3 ubiquitin ligase  ali follow..  7  7ISIFTANLSPTFPCRKVNQLNYFYQLLNLKCFFRSIFKIGHFPRGSPLYLLEKSITFSKIISIFSGHRMGQHGAIRLQNEVQEGMPPPHELTEEEQWAEEHRKMHEKHKGHEAMHMEMMVIF---------------------ISVIVGQIFLVTWKRKHFKSYQMCTLIGMLTIPVYVCFNRSWYRFLATWLVFCIFSAFIWLKASAQHISGGTPRFVYKWFLFLHKLSYVLGVVGYLIMMGALGVSQPTLMDAGILFMFYGVYYGVLGRDFAHICTARMASRIGYYTPEGLPKKHLEDGVCAVCGGRLDDSEHVHDADAVVTTKMVEDEDELYKLSCGHVFHEFCIRGWVVGKLQTCPYCKERVDLQRM. 366
6 -39.500[O] COG5243 HRD ubiquitin ligase complex, ER membrane component  ali follow..  10  34.SFLQVTLKLNEGFNLMVLSIFILLNSTLLWQLLTKLLFGELRLIEHEHIFERLPFTIINTLFMSSLFHERYFFTVAFFGLLLLKDRLEALLQSINDSTTMKTLIFSRFSFNLVLLAVVDYQIITRCISSIYTNQKSDIESTSLYLI-----VMEFTMLLIDLLNLFLQTCLNFWEFYRSQQSLSNENNHIVHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFTGLEGKFMYEKAIDVFTRFLKTALHLSMLIPFRMPMMLLKDVVWDILA------------YQSGTSLWKIWRNNKQLDDTLVTVTVEQNSANDDNICIICMDELNKNKKPKRLPCGHILHLSCLKNWM-ERSQTCPICRLPVFDEKG. 408
7 -37.800[O] KOG3970 Predicted E3 ubiquitin ligase  ali follow..  26  30...........................................................................................................................................................................................................................................................................................................DNHPNCVVQSYLTTDQDYDPNCSLCKTTLAEGDTIR-LNCLHLLHWKCFDEWAANFPARCPCCSQEVFPPIN. 109
8 -37.500[O] KOG0802 E3 ubiquitin ligase  ali follow..  17  214...............................................................................................................................................FQLLDMWINHLAVKNSDCQRSKFIDSMTAGRFFSGVMLCFSI------RARKCILVDIFGSLLEWKGLLNRNLGFFLDMATLVM----ALGHYLHIWWLHGIAFHLVDAVLFLNIRALLSAILKR--------------------KGYIKLRIALGALHAALPDAT-SEELRAYDDECAICREPM---AKAKRLHCNHLFHLGCLRSWLDQGVYSCPTCRKPLFVGRT. 411
9 -37.200[O] KOG0827 Predicted E3 ubiquitin ligase  ali follow..  34  3.............................................................................................................................................................................................................................................................................................................................NLNCVICAELFGQADEVFATVCGHMFHHNCLNQWLDRSK-TCPQCRNKCTTRN.. 54
10 -36.100[R] KOG2442 Uncharacterized conserved protein, contains PA domain  ali follow..  12  1......................................MSLPPFTCRLLAAAAALYLIGLLCVGADTKDVTAPKIPGCSNEFQMVKVENWVNGENGETFTAMTAQFGTMLPSDAVKLPVALTTPLDSCSNLTS-----KLSWSIALSVRGECAFTVKAQVAQAGGAAALVLINDKEEL----DEMVCGEKDTSLNVSIPILMITTSSGDALKKSIMQNKKVELLLYAPKSPIVDYAVVFLWLMSVGTVFVASVWSHVTSPKKNDEQYDELSPKKSSNVDATKGGA-------------------------EEETLDISAMGAVIFVISASTFLVLLFFFMSSWFILILTIFFVIGGMQGICMMINVL..... 298
11 -35.500[S] KOG4445 Uncharacterized conserved protein, contains RWD domain  ali follow..  20  56.............................................................................................................................................................................................................................................................................LRPRGLDDARLEAIRSACNAKIKESIGFPVVFDLIEVVREHLSGSNLPSGQCVVCLYGFADGDEFTRTECFHYLHSYCLARHLNALRRLCPVCREHIGDETD. 179
12 -35.100[O] KOG0828 Predicted E3 ubiquitin ligase  ali follow..  26  678...........................................................................................................................................................................................................................................................................................................KPLSNEYISEHGGGTAEHTVDCAICMSDVKVDQHSYMVPCNHVFHTSCLENWM-NYKLQCPVCRSPLPP.... 757
13 -34.400[O] KOG3268 Predicted E3 ubiquitin ligase  ali follow..  11  228..................................................................................................................................................................................................................................................IALGNNVSINIEVDPRHPTMLPECFFLGADHVVKPLGIKLSRNIHLWDPENSVLQNLKDVLEIDFPARAILEKSDFMDCGICYAYQLDGTIPDQVQCGQPFHQICLYEWLRGLLTECPYCSKPITLKMS. 371
14 -32.900[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  21  213...........................................................................................................................................................................................................................................................................PRSRTVNLHSNDSLTILPRRSAENDPVVDLDVASPPKRVNRDIDESQKEELYKCPICMDSVSKREPV-STKCGHVFCRECIETAI-RATHKCPICNKKLTARQ.. 313
15 -31.300[DO] KOG1493 Anaphase-promoting complex (APC), subunit 11  ali follow..  20  14......................................................................................................................................................................................................................................................................ESQGNDDQQNMSMSSSELHTMQDDHPGILLKTNTRMSITVKKLHVCGEWKWLQGGEDTCGICRMEFESDDCPLVLGCRHAFHRHCIDKWIAAPRAQCPLCRQDWTIVE.. 135
16 -30.400[O] KOG0823 Predicted E3 ubiquitin ligase  ali follow..  22  65.............................................................................................................................................................................................................................................................................VSPNEHRDSTAGVIHERSRERLVENGENKTYLIAKALNMEKTSSVPGGFFDCNICLEKAED-----LTCCGHLFCWGCFYQLPLIYLNECPVCDGEVTDAE.. 164
17 -29.200[O] KOG3800 Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor  ali follow..  19  1..............................................................................................................................................................................................................................................................................................................................KECKKCKSNEYTNKQLVMMECGHPLCKNCVDNIFALNSGNCHVCNRVLRKNN.. 54
18 -28.500[O] KOG1813 Predicted E3 ubiquitin ligase  ali follow..  17  225............................................................................................................................................................................................................................................................................HDRGDYKPGWQIEKEWEEAEKVRKRNKAMGVEDEDDEADKDSDEDENALPFACFICREPFVDP----VTKCKHYFCEHCALKHH-TKNKKCFVCNQPT...... 318
19 -28.200[R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers  ali follow..  17  221...............................................................................................................................................................................................................................................................................................DREWDSVQEKYKKGAKLEEGMVKNEKKEDIPFVCLICKKDYRSP----ATTCGHHFCEQCAITRY-RKTPTCIQCGADT...... 295
20 -27.800[L] KOG0287 Postreplication repair protein RAD18  ali follow..  25  23...........................................................................................................................................................................................................................................................................................................................DTLLRCHICKDFLKV-----LTPCGHTFCSLCIRTHL-NNQPNCPLCLFEFRESL.. 73
21 -27.800[T] COG5432 RING-finger-containing E3 ubiquitin ligase  ali follow..  25  23...........................................................................................................................................................................................................................................................................................................................DTLLRCHICKDFLKV-----LTPCGHTFCSLCIRTHL-NNQPNCPLCLFEFRESL.. 73
22 -27.500[OD] COG5194 Component of SCF ubiquitin ligase and anaphase-promoting complex  ali follow..  20  2...............................................................................................................................................................................................................................................................................SNEVDRMDVDEDESQNIAQSSNQSAPVETKKKRFEIKKWTAVADIAVDNCAICRNHITDNECVAAWGCNHAFHLHCINKWIKT-RDACPLDNQPWQLAR.. 118
23 -27.500[O] KOG2930 SCF ubiquitin ligase, Rbx1 component  ali follow..  21  1...........................................................................................................................................................................................................................................................................................MEVDEDGYEVPSSSSKGDKKRFEVKKWNAVADIVVDNCAICRNHIMEECTVAWGVCNHAFHFHCISRWLKT-RQVCPLDNREWDFQK.. 105
24 -27.500[O] COG5574 RING-finger-containing E3 ubiquitin ligase  ali follow..  17  307...........................................................................................................................................................................................................................................................................KKFDKRTSLTAQPLFFQVIESDPLLLVDNASKAICFSLSSKLFSIIPQLRDFECAICSNVAYK-----RLGCSHVFCLHCLIILQKQKVDFCPLCRAKEVMKA.. 406
25 -26.900[B] KOG4718 Non-SMC (structural maintenance of chromosomes) element 1 protein (NSE1)  ali follow..  14  31...............................................................................................................................YKVHDRSATVDKLEDFINNINSESLYIEIKRGVTEDDGRPIYALVNLATTSISKMATDFAENELDLFRKALELIIDSETG--------------------------------------------FASSTNILNLVDQLKGKKMRKKEAEQVLQKFVQNKWLIEKEGEFTLHGRAILEMEQY-IRETYPDAVKICNICHSLLIQGQ--SCETCGIRMHLPCVAKYFQSNAERCPHCNDYWPHEIP. 230
26 -26.600[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  17  2..........................................................................................................................................................................................................................................................................................................NASTSSPSQQLQQAINSTIDKECAVCYSEMI--LPTTIPSCGHKFCFICLKGVSVSNNGDCPICRGPIDSQI.. 71
27 -26.600[R] KOG3920 Uncharacterized conserved protein, contains PA domain  ali follow..  13  2.............................................................VPGAAGWCCLVLWLPACVAAHGFRIHDYLYFQVLSPGDIRYIKDFGGIFHTRYEQIHLVPAEPPEACGELSN---GFFIQDQIALVERGGCSFLSKTRVVQEHGGRAVIISDNAVDNDSFYVEMIQDSTQR--TADIPALFLLGRDGYMIRRSLEQHGLPWAIISI................................................................................................................................................. 168
28 -26.200[O] KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein  ali follow..  13  79..................................................................................................................................................TGRRGRTLGEEYVDLTYTNRKGAFAYESKIEDTESVAAFCKGLLDFILDVHMTLFYFKGAFYSISKRIFGMRYVFKHILSKNEANFREEGSQKYKVLGYILLAQNVMKWYPVLTSTLGSWIYGRKRTNDSITRSSVGLQERSEHESIEGIPKESQLTHINLSDKNQLIPEASRKCILCLMNMSDP----CAPCGHLFCWSCLMSWC-KERPECPLCRQHCQPQE.. 331
29 -24.200[DR] KOG4739 Uncharacterized protein involved in synaptonemal complex formation  ali follow..  18  2............................................................................................................................................................................................................................................................................................................................DWIQCNHCGIKPNQ-TKLYLTACGHVFCQNCTKAAF---NSQCYLCKKPLKVDE.. 51
30 -24.000[O] KOG4265 Predicted E3 ubiquitin ligase  ali follow..  19  243.............................................................................................................................................................................................................................................................................................VDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRD---TLILPCRHL--TSCADT-LRYQANNCPICRLFP...... 320
31 -23.700[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  17  249.......................................................................................................................................................................................................................................................................................KKLYRKRKQEREEAKIRERLDTERRERRARSRPHTLSQDQLCVVCSTN-----EIILLPCGHV--EDCAQ----KISVTCPVCRGSI...... 329
32 -23.000[R] COG5219 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  9 1325LLVWDLIFYHFEETTYNIKLSIINLHAMDLLRPLLNTLVEILNLSYDRPINVDKYPKIDYNLMDYSSATDRIRCLAIHIYYQCLR-------------------------------------------------HLSSSVRSYWSEVKN---AFTSTVESFTGYNVSPLLISASLDDVERSIESEDFQSVGD-------NVKVNRNTREISFIYNVDEHKLEMAIKIPSVY---------------------------------LQNVQVEGIERVGVNERQWRSWILASQSILSSQNGSITDALLVLKKNISMHFEGEECAICYSVLSVERTLPNKRCRHKFHASCLYKWFSSNSSRCPLCRSSF...... 1607
33 -22.400[DKL] COG5220 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3  ali follow..  15  3......................................................................................................................................................................................................................................................................................................................DEGARKVDEKCPLCQADRYLNPNMKNPECYHKMCESCVDRIFTTGPAQTPGCNKILRKAK.. 67
34 -22.200[O] KOG1100 Predicted E3 ubiquitin ligase  ali follow..  16  228.....................................................................................................................................................................................................................................................................LQQVLAAVERNRWEEPPTVADDAQSCCGSNDEGDSEEERWKLAGEAQDTKKMCRVGMSMCRSCGKG-----SVLLLPCRHM--SVC-----GSSLNTCPICKSPK...... 325
35 -22.100[O] KOG0826 Predicted E3 ubiquitin ligase involved in peroxisome organization  ali follow..  9  72..................................................................................................................................................LRKRASSFGESFYGLQRTVTTT-------------GDLLNRRQQFASATLLTFMPYVERKLRTRITRHEDTSPWEQRLLSAFHAFHAAKAAHTFFYLVKYASNHSPIFRLLGLTLRYPSEPPKEDQWTYVVLKMLEVYSNDQRRKVGGTLINPEAMPRKQLPKEVQQSLPQRGECPVCLLSIQTPTAC--SVSGYVFCWKCIVSHM-KEHGTCPVTHYPISLDD.. 290
36 -22.000[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  6  51..........................................................................................................................................................................................................................................................................QEEDEEEEEEEDSERQTREYIDVLDSPVRVSQNESEGIENQNRRMSNGNKVTLRDCLVLSVWKFGPAVANTKSGILDSIVFPVDTCMDITSGFSSDEVEGSLRD.. 157
37 -22.000[R] KOG4299 PHD Zn-finger protein  ali follow..  15  213...........................................................................................................................................................................................................................................................................NNVTRNVTVYSNQKHLGNESENFNDMEGRAEDISSNELLPTPEEYPYRYNNDYCSAC----GPGNFL----CPNSFHFTCIDPWY------CNECKHHSLYNE.. 317
38 -21.400[R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  12  253...........................................................................................................................................................................................................................................................................................DKQSWEDYQRKRENRQIDGDETIWRKGHFKDLPDDLKCPLTGGLLRQ-----KTSCNIDFSKEALENALVESDFVCPNCETRDILLDSL 340
39 -20.600[K] COG5175 Transcriptional repressor  ali follow..  19  7......................................................................................................................................................................................................................................................................................................QENLQAIHNALSNFDTSFLSEDEEDYCPLCIEPMDITDKFFPCPCGYQICQFCYNNIRQELNGRCPACRRKYDDEN.. 85
40 -20.600[O] KOG2164 Predicted E3 ubiquitin ligase  ali follow..  17  200..................................................................................................................................................................................................................................................................................................................VWQVLCSSDFQLAACPFCLEEKPVAARM--SRCGHVYCFSCLLRFVETPTAACPICWDSIRLRD.. 280
41 -20.500[S] KOG2660 Locus-specific chromosome binding proteins  ali follow..  17  2..................................................................................................................................................................................................................................................................................................................MIKVKKETMRACLSCSICDNILRD---------ATTISEKCIYEKITEDEITCPVCNIDLGSTP.. 57
42 -19.900[R] KOG3002 Zn finger protein  ali follow..  18  5............................................................................................................................................................................................................................................................................GSALKEALESNSTGVDYEVKMAKVEANSKPTKSGSGSIGKFHSSNGVYELLECPVCTNLMY--PPIHQCPNGHTLCSSCKL----RVQNTCPTCRYEL...... 96
43 -19.800[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  16  312..............................................................................................................................................................................................................................................................................................................VMMAAVKTYRWQCIECKCCNICGTSENDDQLLFCDDCDRGYHMYCLTPWS------CHLCL......... 375
44 -19.800[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  22  643......................................................................................................................................................................................................................................................................................................................AVEKLATDELCKICMDA-----ECVFLECGHM--TSCGKV------NECPICRQYI...... 691
45 -19.700[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  12  142.............................................................................................................................................................................................................................................................................VAEGAEDDLQEDFHVEGMKTKSGRKIQRPVAYNPNATALKRKSRKVDMVTLCSVCQRGHSPLSNRIVF-CNSPYHQLCHHPWF------CMKCQYR....... 246
46 -19.200[O] KOG2879 Predicted E3 ubiquitin ligase  ali follow..  9  17....................................RLLPESQSLLASRRSVIPVAISRVNQFDAARLDVEMSAMLKEQLVKVFTLMKPGMLFQYEPELDVDKPTPGNALMNLRYRDERGVVAQHLGKGLEGPGLTSPQKIWYCVASV-----LFSRLQSFSAFRRWGDSEQRPLARRLWTLVQRIEGIYKAASFLNLLSFLYTGRYRNLIEKALKARLVYRSPHMNRSVSFEYMNRQLVWNEFSVGLLYPSIDQNILFRLATRNVMLGSDFLVLFWHSALNLFGDIQEMLLLLLPLLNKNILSPFAKDKSSSTKEDTVTCPICQVDPAIPFIA-KELTCRRYCYYCIRTRCASAASRCLRCNEPVVAIQRE 383
47 -19.100[L] COG5627 DNA repair protein MMS21  ali follow..  18  184....................................................................................................................................................................................................................................................................................................................EVMVYSATFDNRCPLTLQPIV--HPILSTACNHFYEKDAILSLL-NPTCVCPVCEARLQRSL.. 244
48 -18.700[S] KOG4638 Uncharacterized conserved protein  ali follow..  11  307................................................................................................................................................................................................................................................LFSSLMTGLYLTFKLTSVVEKLREIGNEIQVQSFFTALKALSRKEVHYGSYAT-----------------TEQATCVPSARRRCTPQFFFAANTCAFQSGEVFLHIAIIFVYEYLDV............... 410
49 -18.600[O] KOG4692 Predicted E3 ubiquitin ligase  ali follow..  16  420.............................................................................................................................................................................................................................................................................RADPPILKFALNDFPSHVSSEEIDNVRRLIDSLRVKQTLLSDITLPSEDSLCPICCAKPIT---AVFTPCKHQSCSDCIMQHMMN-SKVCFYCKTTI...... 512
50 -18.500[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  17  788.....................................................................................................................................................................................................................................................................ISRRTDDIKLELDDEREKKKLEEELMELNKELEELGSESVEAAIVRLQEEVKNCKNILKCGVCFDRPKEVVIVK---CYHLFCQQCIQRSLEIRHRKCPGCGTAFGQND.. 893
51 -17.300[R] KOG2979 Protein involved in DNA repair  ali follow..  14  191......................................................................................................................................................................................................................................................................DEFTKLKATPSSVPQNDHLMRQFREAVWNVHHAGEPMPGDDDEDIVMTSTQCPLLNMTCPLSGKPVTE-DPVRSMDCRHVYEKSVILHYIVNNPNNCPVCRGKLQNSK.. 302
52 -16.600[O] KOG4185 Predicted E3 ubiquitin ligase  ali follow..  25  1...........................................................................................................................................................................................................................................................................................................................MSFIDCEICDEEFSTLTDVNILRCGHTTCHGCAEKLLRNSTILCPFCREATNVSA.. 58
53 -16.500[O] KOG1814 Predicted E3 ubiquitin ligase  ali follow..  9  4................................................................................................................................VEVESDNKHLVADELIAL----QSIYPEIHLDGNNYGRLNIPVNTESDYFLSFKSPDESTLTDTIVVRHFPDLVMEFFLPEAYPFNSPPTFFLKSSWLPLKQKRVLTSSLIKLWNEIHDCVLFDAI------------------EHVRSIATIAFHLPTEMVFPGGFDDLKKEILAFDKNAKLLEFQIRKFQCNVCFDEFNGTDCFQLTRCGHVSCQSCLRDYYTMCQIKCI-CGKDAPV.... 230
54 -16.500[B] COG5034 Chromatin remodeling protein, contains PhD zinc finger  ali follow..  16  197..........................................................................................................................................................................................................................................................................SSPPLSSTKHAPQSTERRPVRRSESRLKQTNGEPLVKHDTLDSSDISREGEQLYC-YC-QQVSYGQ---MIGCDNEFHLPCVGIWY------CKECEEL....... 297
55 -16.000[O] KOG0006 E3 ubiquitin-protein ligase (Parkin protein)  ali follow..  11  182....................................................................................................................................................................................................................................................................................................FKCGAHPTSDKETPVALHLIATNSRNITCITCTDVRS-PVLVFQCNSRHVICLDCFHLYCVTRSLPCV-PNSLIKELH.. 274
56 -15.000[R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein)  ali follow..  14  136.....................................................................................................................................................................TEGIMFYKYNDEKLT--------KVAQCRMLCMYAV--AQVEVREIISFMCISLPMIVSIKVVRDPAPNQYMLII-----------------------KFKEHNDAVTFYEEFNNCPFNDLESYCCTLFFVDRIECTTSNDLFSSDDTSLTELPTCAVCLERMD--DSVLAILCNHSFHARCLEQWA---DNTCPVCRYVQSPEVV. 305
57 -14.700[B] KOG1973 Chromatin remodeling protein, contains PHD Zn-finger  ali follow..  15  223..........................................................................................................................................................................................................................................................................KKKKSKVNQEKETRKGGAQKKTVEVDDSEKESCHTAATHPSDVMDMPVDPNEPTYCLC-HQVSYGEMIGCD-PIEWFHFACVGKWF------CPKCTQD....... 324
58 -14.500[U] KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11  ali follow..  16  683...............................................................................................................................................VILCEMNS--KDGLLYLYEKMKFYKEVIACYMQNHDHEGLIACCKRLGDSSKGGDPSLWAD-----------------LLKYFGEIGEDCTKEVKEVLTYIERDDILPPIIVLQTLAKNPCLTLSVIKDYIARKLEQESKIIEEDRRAVEKYQETTKNMRKEIEDLRTNARIFQLSKCTACTFTLD--IPAVHFMCMHSFHQRC----LGDNEKECPECAPE....... 880
59 -14.500[O] KOG4159 Predicted E3 ubiquitin ligase  ali follow..  25  1.............................................................................................................................................................................................................................................................................................................................................MRLFPCGHSFCKNCLERCL-DHAPYCPLCKESLKE.... 40
60 -13.600[O] KOG1815 Predicted E3 ubiquitin ligase  ali follow..  19  94.....................................................................................................................................................................................................................................................................................LRHFHWSVGRVHDEWFADEERVRKTVGILESHVVPPSDDSELTCGICFDSYP-PEKIASVSCGHPFCTTCWTGYISTTMLRCP-CLAAVGHD... 194
61 -13.600[R] KOG3005 GIY-YIG type nuclease  ali follow..  25  330......................................................................................................................................................................................................................................................................................................................KREDYLEMGECRICGKDIEKLWSLVRCICPSHFHSKCLSENVYPLKANCPTCGQFY...... 399
62 -13.400[O] KOG1039 Predicted E3 ubiquitin ligase  ali follow..  12  20.............................................................................................................................SQC-LFSHDLANSKPSTICKYYQKGYCAYGTRCRYDHTRPSAAAGGAVGTMAHSVPSPAFHSPHPPSEVTASIVKTNSHEPGKREKRTLVLRDRNLSGMAERKTQPSMVSNPGSCSDPQPSPEMK--LCPYAAAGECRFGDACVYLHGEVCEICRLQVLHPFDPEQRKAHEKICMLTFEHEMEKAFAFQASQDKVCSICMEVILEKASASLSNCNHTYCLSCIRQWRCAKQKSCPECRVISEFVIP. 300
63 -12.900[S] KOG3113 Uncharacterized conserved protein  ali follow..  9  48.......................................................................................................................................................................................................................................................IVACELGRLYNKDAVIEFLLDKSAEKALGKAASHIKSIKNVTELKLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLCCGCVFSERALKE----KAEVCHTCGAAFQEDD.. 168
64 -12.500[DR] KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins  ali follow..  18  536.............................................................................................................................................................................................................................................................................................YKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDK---EVSVVFIPCGHL--QEC-----APSLRKCPICRGII...... 609
65 -12.500[T] KOG0297 TNF receptor-associated factor  ali follow..  16  29...........................................................................................................................................................................................................................................................................................................................EAKYLCSACRNVLRR-----QAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEG. 81
66 -12.300[O] KOG4172 Predicted E3 ubiquitin ligase  ali follow..  24  2......................................................................................................................................................................................................................................................................................................................GAQEVNEGDECTICMDA---PVNSVLYTCGHM--FECGRR-LLTTKGTCPICRAPV...... 54
67 -12.200[R] COG5236 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  16  6......................................................................................................................................................................................................................................................................KENVTPTRNFRRTQGPQNNTKPHNDRKNFRRKQKKNNLSAEPNLTTSSADDTDEENELCVICARKL---TYVSLTPCHHKTCHIC----ALYNKKSCLICRTEN...... 107
68 -12.000[K] KOG2169 Zn-finger transcription factor  ali follow..  12  368......................................................................................................................................................................................................................................................AAGVYFVHRVNSDILFKRLNQNVSRHRSLEVTKQEVIKKLSGGEDDIAMDRLNISLL-----------------DPLCKTRMT---PSRCQDCTHL---QCFDTW------QCPVCSSNCPYDR.. 475
69 -12.000[O] COG3058 Uncharacterized protein involved in formate dehydrogenase formation  ali follow..  17  178....................................................................................................................................................................................................................................................................................................................KARAEYGEQRQYCPVCMVQIGTTQGLRYLHCN------CETEWHVV-RVKCSNCEQS....... 235
70 -12.000[R] KOG0490 Transcription factor, contains HOX domain  ali follow..  17  6......................................................................................................................................................................................................................................................................................................AGCERPILDRFLLNVLDRAWHIKCVQCCECLSEFSREGKLKCAGCAKVFHLNCF---------TCMVCNKQLSTGEEL 105
71 -11.900[R] KOG2789 Putative Zn-finger protein  ali follow..  13  93......................................................................................................................................................................................................................................................................AIRQSRSLSVGNTRSLKRDSRGSSDHLLTRNRSNSTPGSISADYRTTAITTIYANAMECPICFLYYPSNNYTR---CAQPICSECFEP-LISEPAKCPYCMTEVIYKPN. 224
72 -11.900[U] KOG2066 Vacuolar assembly/sorting protein VPS41  ali follow..  9  482....SALKILMSCQDFQIFNVIDKHQLFDLVKDQITELMNINSERALRLLLDNAD----------SVEPSFVMEKIGRQPKLQLAYLTKLMSRNEGTEFADKAVQLYAEYDQKKLLPFLRKNANYNVNKARKLCSDKGYIEETIYLLAKSG----------NHYDAVKMMVREYRN----MEKVIDYCKDQNDPDLWIHLLGVVAEFPAHFSQLIIEASNC------------------LDPLLIMDKLPDDSDIPNLSEALDKLLVDYTNHAELQQCCYDSTLNDLNVLTQGLISAADESVSV-----------NIVSRCSLCAQIIINSNDIKVFKCGHIFHLACSTSEMERRQSICIACSDQ....... 801
73 -11.800[U] KOG3799 Rab3 effector RIM1 and related proteins, contain Rab3a binding domain  ali follow..  14  23.....................................................................................................................................................................................................................................................................HTQNNGYAIKRVFKRQKDEEAKETQISQKASEELSELDKQITERKETSKKLVGTQDDAICQICQKTFADGIGHKCFYCQLRSCARC-AIWA------CSLCQKR....... 129
74 -11.700[K] KOG4577 Transcription factor LIM3, contains LIM and HOX domains  ali follow..  15  20......................................................................................................................................................................................................................................................................................................................LGVPMQQIPQCAGCNQHILDKFILKVL--DRHWHSSCL---------KCADCQMQL...... 64
75 -11.700[S] KOG3931 Uncharacterized conserved protein  ali follow..  17  531..........................................................................................................................................................................................................................................................................AANESLTAATELADQSIIDDIFGEDTLLKEFQRENDVQPSCSSYAKRIENDIVSCPICFEKMRRTE-------NHF--DGCAIM-LFKETVGCPRCGLEIMPLH.. 710
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Ye Y, Osterman A, Overbeek R, Godzik A. Automatic detection of subsystem/pathway variants in genome analysis. Bioinformatics. 2005 Jun 1;21 Suppl 1:i478-i486.