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Query: [O] COG5243 HRD ubiquitin ligase complex, ER membrane component, from COG0516

Results of FFAS03 search in COG0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVPENRRKQLAIFVVVTYLLTFYCVYSATKTSVSFLQVTLKLNEGFNLMVLSIFILLNSTLLWQLLTKLLFGELRLIEHEHIFERLPFTIINTLFMSSLFHERYFFTVAFFGLLLLYLKVFHWILKDRLEALLQSINDSTTMKTLIFSRFSFNLVLLAVVDYQIITRCISSIYTNQKSDIESTSLYLIQVMEFTMLLIDLLNLFLQTCLNFWEFYRSQQSLSNENNHIVHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFTGLEGKFMYEKAIDVFTRFLKTALHLSMLIPFRMPMMLLKDVVWDILALYQSGTSLWKIWRNNKQLDDTLVTVTVEQLQNSANDDNICIICMDELIHSPNQQTWKNKNKKPKRLPCGHILHLSCLKNWMERSQTCPICRLPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGIPVKLTIENHEVNSLHGDGGEQIAKKIVIPDKFIQHILast
1 -135.000[O] COG5243 HRD ubiquitin ligase complex, ER membrane component  ali  100  1MVPENRRKQLAIFVVVTYLLTFYCVYSATKTSVSFLQVTLKLNEGFNLMVLSIFILLNSTLLWQLLTKLLFGELRLIEHEHIFERLPFTIINTLFMSSLFHERYFFTVAFFGLLLLYLKVFHWILKDRLEALLQSINDSTTMKTLIFSRFSFNLVLLAVVDYQIITRCISSIYTNQKSDIESTSLYLIQVMEFTMLLIDLLNLFLQTCLNFWEFYRSQQSLSNENNHIVHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFTGLEGKFMYEKAIDVFTRFLKTALHLSMLIPFRMPMMLLKDVVWDILALYQSGTSLWKIWRNNKQLDDTLVTVTVEQLQNSANDDNICIICMDELIHSPNQQTWKNKNKKPKRLPCGHILHLSCLKNWMERSQTCPICRLPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGIPVKLTIENHEVNSLHGDGGEQIAKKIVIPDKFIQHI 551
2 -95.500[O] KOG0802 E3 ubiquitin ligase  ali follow..  16  11ASTALSFVGLQVWTELSLDLRADGLIAKNISLGDSEHALELLGSYFTIALLTNFVLNVYILLVLSLKTLFFGDLYDVETKKLVERLANYIIYKGTFLPLVTIFQGVLWTVWLTVLCTLKMFQALARDRLERLNASPSSTP----WTYFRVYSVLFLVLSVDMFWIKLSLMTYNTI------GSAVYLLLLFEPCSIAFETLQALLIHGFQLLDMWINHLAVKNSDCQRSKFIDSMTAGRFFSGVMLCFSRARKCILVDIFGSLLEWKGLLNRNLGFFLDMMALGHYLHIWWLHGIAFHLVDNIRALLSAILKRIKGYIKLRIALGALHAALPDATS---EELRAYDDECAICREPM-------------AKAKRLHCNHLFHLGCLRSWLDQGYSCPTCRKPLFVGRTENEVNPRTVEVSSDEQLARQLERQNNPVHALATGLFPAEVPDSVENDTSRNLGLDPSWLQTWSSQGSDVAGPSTTSRTVGPMNPSQASTSSTTVPPGNGGRTGGLHLRTVSNTTNESLTNILAMAETVREVMPHVPDEIIFQV 585
3 -61.200[O] KOG1734 Predicted RING-containing E3 ubiquitin ligase  ali follow..  4.................................SYFISIFTANTFPCRKVNQLNYFYQLLNLKCFFRSIFKIGHFPRGSPLYLLEKSITFSKIISIFSGHRMGQHGAIRLQNEVQEGMPPPHELTEEEQWAEEHRKHEKHKGHEAMHMEMMVIFMISVIVGQIFLVTWKRKHFKSYQMCTIPVYVCFNRSWYRFLATWLVFCIFSAFIWLKASAQHISGGTPRFV------------------------------------------YKWFLFLHKLSYVLGVVGYLIMMGAL-MDAGILFMFYGVYYGVLGRDFAHICTARMASRIGYYTPEGL----PKKHLEDGVCAVCGGRLDDSEHVHDVEDEDEKLYKLSCGHVFHEFCIRGWVGKLQTCPYCKERVDLQRMFKNPWEKPH...................................................................................................................................... 375
4 -30.100[O] KOG0801 Predicted E3 ubiquitin ligase  ali follow..  19  127.....................................................................................................................................................................................................................................................................................................ALPLHIAPRWFSSHSGFKCPCSKSVASDEMEMHFIMCLSKPRLSYNDDVLTKDGECVICLEELLQGD----------TIARLPCLCIYHKSCIDSWFEVNRSCPEHPAD..................................................................................................................................................... 227
5 -29.600[O] KOG4628 Predicted E3 ubiquitin ligase  ali follow..  12  7...........................................................................................................QILTLLGLCLVCHEATLVGGHVLVYRKATSQLIEEFNDLPAQFGPNLPSNGLKVYVVPYYGCDSLDRPPHLKYPPSAKFVALVARGECVFERKIRVAQNASYSAVIVYNNEGDDLEQMSAENITGIRIPSVFVGHTTGKALATYFTTEVVLIINDELPFNINTQLILPFSILIG---------------MCFIIMVIYMIYKCIREQRRLRRHRLPKSMLKKL--PVLRYTKNNANNKYDTCVICLEDFI----------EDDKLRVLPCSHPYHTHCIDPWLENRRVCPICKRKVFTKGEARASRSRQPSLDNVTDTDDDTTPLLQQQQSNGRQVGQVSSASSAGGAAGSSSSVAAAAVAGTTRHGTFRRGHAGRNPFEESQSSDDENALLASTVRPATSSGAHERINPFDRAPNLPAHLAEQLTES................ 412
6 -26.800[O] KOG0828 Predicted E3 ubiquitin ligase  ali follow..  11  387TRYELKIMSIRKHLLFGIALFAAQIYLLLTQMHH-TNTPSMVNKISFYCFSMINLVDGSLATLYFVAASVVPELYLP-----------LVISAFSCFILA---------SIFEIRYLISIYASQVNEQNVGIINLLRGNTGTYGSLYGRFFFMLIIFTFL--------------------------ILSSTSWPRQLRMVFEYILIFILNSYWIPQIFRNAVKGIPSRRERARSSIGGNRSQNKMPL-------------------LWSFVIGTTIIRSLPVVYVFTVFRHHKDVHFVVFLSLWLLFQISILYSQDVLGSRDGYSYFKPLSNEYISEHGGGTAEHTVDCAICMSDVPIYIEEIPETHKVDQHSYMPCNHVFHTSCLENWMNYKLQCPVCRSPL.................................................................................................................................................... 755
7 -26.500[O] KOG0800 FOG: Predicted E3 ubiquitin ligase  ali follow..  11  26...................................................................................................................................................................................................................................................................................FIFSVPICFTFIILFLFYLIYLRRSSSDLSSLGMRTTFIPGNSLSTIELKELREMLPIVVFKESFTVMDSQ--CSVCLGDYQ----------PNDKLQQIPCKHTFHMDCIDLWLTSHTTCPLCRLALIPSRSRQSQDDPVPSLVSPDEEVSSQPESEPVNHRVVSTQPESEPVNHSGVSSQPESQPVVNHRGVSSQPES............................................................................ 217
8 -26.200[O] COG5540 RING-finger-containing ubiquitin ligase  ali follow..  15  244............................................................................................................................................................................................................................................................................SPSIIMLITVQALAIRKFIRTYRTKSKTRRFIEDL----SRTISREGFYSEEEEIENSTQNGELVPLMDESTRRATFGVECVICLESFT----------KGDKVVALPCKHEFHRPCIAKWIDYRHACPTCNTEVPPPKP............................................................................................................................................... 371
9 -25.800[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  20  239.................................................................................................................................................................................................................................................................................................................................VVDLDVASPPKRVNRDIDESQKEELYKCPICMDSVSK-----------REPVSTKCGHVFCRECIETAIRATHKCPICNKKLTARQ................................................................................................................................................ 313
10 -25.400[O] KOG3970 Predicted E3 ubiquitin ligase  ali follow..  12  4..................................................................................................................................................................................................................................................................................................................CKCPKRKVTNLFCYEHRVNVCEFCLVDNSYLTWLTDQDYDPNCSLCKTTLAEGDT------------RLNCLHLLHWKCFDEWAANGYRCPCCSQEVFPPINEVSPLIEKLREQLKQSNWARAALGLPTLPELNRPVPSPAPPQLKNAPVMHKEVPVHNNRSSTPATHLEMEDTASYSVSNNDVTFARKKNYGAESSSDTRPLLQLRDADNEENKYKRRPTM....................... 229
11 -22.800[O] KOG0827 Predicted E3 ubiquitin ligase  ali follow..  12  5...........................................................................................................................................................................................................................................................................................................................................................NCVICAELFGQADE----------VFATVCGHMFHHNCLNQWLDRSKTCPQCRNKCTTRNIFRVYFNLANLDVSHIDVGSLQEQLDNAMLSMKMVEKERNKDEQQIRDLKETQKKCLKTIAGLEQKVQKKDFLISSYVEQIGVLKSDAHVVDGLRKENKTLKSQIQSMEGISAILAAGSADADRLLKHVLANWVSTLKRELRQC 203
12 -21.400[S] KOG4638 Uncharacterized conserved protein  ali follow..  136.............................................................................DIQQAARWIEQILPFSLLLLVVFIRQHLQGFFVAIWIAAVMFKSNDILKKQTALKGERH-----------ISALIGISVAFTAHVVGVYWWFRKPLIMLPPKSIPPFWHAIFIIVYPVGSFGAYSLVPIFLRYTCPAGLNDFQGQLLT---------------------LVEYFMLLYRSLLPTPVW-----YRFFLNKDYGSLFSSLMTGLYLTFKL-----TSVVEKLREIGNEIQVQSFFTALKALSRKEVHYGSYATTEQATCVPSARRRCTPQF------FFAANTCFAKIAFQSGEVFLHIAIIFYLDVER............................................................................................................................................................. 412
13 -20.000[O] KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein  ali follow..  11  29.........................................................................VQAHQKDQIQGLLIMKVTELCKLIK-YPKELSIFAKLLYLLFTTGRRGRTLGEEYVDLTYTNRKGTRLAGRLK--MI--VFAFAYPLCPYFITKLYKKIMKNNKESKIEDTESVAAFCKGLLDFILDVHMTLFYFKGAFYSISKRIFGMRYVFKHILSKN-------------------------------EANFREEGSQKYKVLGYILLAQNVMKWYPVLTSTLGSWIYGRKRTNDSITRSSVGLQERSESQLTHINLSDKNQLPFIPEASRKCILCLMNM-------------SDPSCAPCGHLFCWSCLMSWCKERPECPLCRQHCQPQE................................................................................................................................................ 331
14 -20.000[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  20  1......................................................................................................................................................................................................................................................................................................................................MNASTSSPSQQLQQAINSTIDECAVCYSEM-------------ILPTTIPCGHKFCFICLKGVSVSNNDCPICRGPIDSQIFKKPLQAVDLKMDIPGTPSAAAPDPVVKQ................................................................................................................... 100
15 -19.900[OD] COG5194 Component of SCF ubiquitin ligase and anaphase-promoting complex  ali follow..  17  28.................................................................................................................................................................................................................................................................................................................................VETKKKRFEIKKWTAVAFWSWDIAVDNCAICRNHIME-QPKAMTDTDNECVAAWGCNHAFHLHCINKWIKTRDACPLDNQPWQLAR................................................................................................................................................ 118
16 -19.800[DO] KOG1493 Anaphase-promoting complex (APC), subunit 11  ali follow..  22  69.........................................................................................................................................................................................................................................................................................................................................................EDTCGICRMEFESACNMCKFPGDDCPLVLGICRHAFHRHCIDKWIQPRAQCPLCRQDWTIVE................................................................................................................................................ 135
17 -19.600[O] KOG4265 Predicted E3 ubiquitin ligase  ali follow..  12  81...................................................................................................................................................VKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFD------ADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDT---------------LPCRHL--TSCADTLRYQANNCPICRLFPGPPADPGGAEEARSPVPRVLQPRPGPEPGA...................................................................................................................... 350
18 -19.300[S] KOG4445 Uncharacterized conserved protein, contains RWD domain  ali follow..  13  33................................................................................................................................................................................................................................................................................YVCVTLQVHPTPGYFKLLRPRGLDDARLEAIRSACNAKIKESIG--------FPVVFDLIEVVREHLSGSNLPSGQCVVCLYGFA----------DGDEFTRTECFHYLHSYCLARHLNALRLCPVCREHIGDETDSLKCAMPPSELLNAPEFKVTEELRQMQQRMSELYLQQKSRGAIIDVNAEGSAVISIETEEDIRRRRRREEAEAAKKLEGPSKEEVIKPTTSSTFAPVVQETHRIMPEPTNNNYHHNRRHYRGGRRHHHHHQH........... 311
19 -19.200[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  23  604...........................................................................................................................................................................................................................................................................................................VKQLKEVLMLHRVDYKGCCEKQELLDRVSRLWKTMRECPAVEKLATDELCKICMDAPIE----------------LECGHMA-TSCGKV-LNE---CPICRQYI.................................................................................................................................................... 691
20 -19.000[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  78.................................................................................................................................................................................................................................................................................................................................VRVSQNESEGIENQNRRMSNGNKVTLRDCLVLSVWKFGP----------AVANTKSGILDSIVFPVDTCMDIPAFSSDEVEIYASRVAAVDDEAHKRILFLEAKLRSIEQKTASWSNKEVQ............................................................................................................. 200
21 -19.000[O] KOG2930 SCF ubiquitin ligase, Rbx1 component  ali follow..  15  15.................................................................................................................................................................................................................................................................................................................................SKGDKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTCNHAFHFHCISRWLKTRQVCPLDNREWDFQK................................................................................................................................................ 105
22 -18.900[O] KOG0823 Predicted E3 ubiquitin ligase  ali follow..  14  89.................................................................................................................................................................................................................................................................................................................................NGENKTYLIAKALNMEKTSSVPGGFFDCNICLEKA-------------EDPILTCCGHLFCWGCFYQLPLNIKECPVCDGEVTDAEGNGDDCDGTKPKLEDCGISLPPRPNAKRVESVRQKIINR......................................................................................................... 208
23 -18.500[T] COG5432 RING-finger-containing E3 ubiquitin ligase  ali follow..  13  1......................................................................................................................................................................................................................................................................................................................................MDHQITTASTTSIPSLYQLDTLCHICKDFL-------------KVPVLTPCGHTFCSLCIRTHLNNQPNCPLCLFEFRESLLRSEFLVSEIIQSYTSLRSSLLDALRIPKPTPVPENEEVPGPENSSWIELISESESDSVNAADDDLQIVATSERKLAKRSMTDILPLSSKPSKRNFAMFRSERIKKKSKPNEQMAQCPICQQFYPLKALEKTHL.......... 207
24 -18.500[L] KOG0287 Postreplication repair protein RAD18  ali follow..  13  1......................................................................................................................................................................................................................................................................................................................................MDHQITTASTTSIPSLYQLDTLCHICKDFL-------------KVPVLTPCGHTFCSLCIRTHLNNQPNCPLCLFEFRESLLRSEFLVSEIIQSYTSLRSSLLDALRIPKPTPVPENEEVPGPENSSWIELISESESDSVNAADDDLQIVATSERKLAKRSMTDILPLSSKPSKRNFAMFRSERIKKKSKPNEQMAQCPICQQFYPLKALEKTHL.......... 207
25 -18.400[R] COG5219 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  12 1147IKYAMKMSVVDAPIVKSFELFALRLYNALSKNYEMNSDIKDCIVESNESMNYLLLKRFLFT--RMCNQYLVKLLENCPGKVVRSFQYQEFFPSLCNSNDLQME-----------SVCMKFLREKLSHELKELTVYYMVESDYEPDVSLELLSLAIYLLVWDLIFTTYNIKLSIINQLHAMDLLRPLLNTLVEILCLAIHIYYQCLRHLSSSVRSYWSEVKNRAFTSTVESFTGYNVSPLLISASLDDVERSIESEDFQSVGD--TREISFIYNVD------EHKLEMAIKIPSVYPLQNVQVEGIERVGVNERQWRILASQSILSSQNGSITDALLKNISMHFEGVEECAICYSVLSVE-------------RTLPCRHKFHASCLYKWFKNSSRCPLCRSSF.................................................................................................................................................... 1607
26 -18.300[O] KOG0826 Predicted E3 ubiquitin ligase involved in peroxisome organization  ali follow..  11  17.....................................................................IFEISASETLDNLIYPALSKIFDYFGGSLRIQEELSPLLTWLLQYLYLRKRASSFGE---SFYGLQRTVTTTGDLLNRRQQFASATLLTFMPYVERKLRTRITRHEDTSPWEQRLLSAFHAFHAAKAAHTFFYLVKY-IFRLLGLTLRYPSEPPKEDQWTYVV--------------------------------------------------------------LKMLEVLAFFLQFVQWWYSNDQRRKVGGTLINPEAMPRKQLPKEVQQSLPQRGECPVCLLSIQTPTA-------------SVSGYVFCWKCIVSHMKEHGTCPVTHYPISLDD................................................................................................................................................ 290
27 -17.800[O] KOG4692 Predicted E3 ubiquitin ligase  ali follow..  13  68LGIHSADPRIVLASCKDSLLQALGTLTCHKSGVRALERTSKRSQASLVALLRPYENRAWGQSNWLLLRFWMGEYKDSRQPSVWQG--SKHFQRLIGAKLLEDEPFAT--VLSQLNWAFSEFILLLQEIQNTAQRQENTLFEPKQLKICSMCFELTVSLMRCLEMVITTAPEIVTDESRPNSDLLLNRICQLISQVLSYPIVTAALGILLALMQEEMESDLRPQIVTRVSRAFLTDPSFQFATLEFALGEIRTPLLEQKNIPRGNFDPSSRPHIDPLTNDVRVPLPNNSKRIRADPPIL------FALNDFPSHVSS--EIDNVRRLIDSLRVKQTLLSDITLPSEDSLCPICCAKP-------------ITAVFTPCKHQSCSDCIMQHMMNSKVCFYCKTTIQTIETLDGTVIFSNDDVVQTPMIERA.......................................................................................................................... 538
28 -17.800[O] KOG3268 Predicted E3 ubiquitin ligase  ali follow..  10  8.........................................LLRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVLPEDLQLKNARLLCSWQLRTILSGYHRIVQQRMQHPPDLMSFMMELKMLLEVALKNRQELYALPPPPQ--FYSSLIEEIGTLGWDKLVYADTCFSTIKLKAEDASGREHLITL------KLKAKYPAESPDYFVDFPVPFCASWTPQSSLISIYSQFLAAIESLKAFWD-VMDEIDEKTWVLEPEKPPRSATARRIALGNNVSINIEV----------RHPTMLPECFFLVVKPLGIKLSRNIHLWDPENSVLQNLKDFPARAILEKSDFTMDCGICYAYQLDGT-------PDQVCDNSQCGQPFHQICLYEWLRGLLECPYCSKPITLKMSGRKH........................................................................................................................................... 375
29 -17.400[O] KOG2879 Predicted E3 ubiquitin ligase  ali follow..  52....................MSAMLKEQLVKVFTLMKPGMLFQYEPELDAFLEFLIWRFSIPGNALMNLRYRDERGVVAQHLGKGLEGPGLTSPQKIWYCVASVGGQYLF--------RLQSFSAFRRWGDSEQRPLARRLWTLVQRIEGIYKAASFLNLLSFLYTGRYRNLALKARLVYRSPHMNRSVSFEYM-LVWNEFSVGLLYPSIDQNILFRLATRNVMLGSDFLVLFWHSALNLFGDI-------------------------------------------------------------------QEMLLLLLPLLNSSAVKNILSPFAKDKSSSTKEDTVTCPICQVDPAIPFIALPCQH--YIHLKELTCRRYCYYCIRTRCASAARCLRCNEPVVAIQREGVSSGK........................................................................................................................................ 389
30 -17.100[R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers  ali follow..  14  207...............................................................................................................................................................................................................................................................................................................FLHMREDYKAGWQLDREWDSVQEKYKKGAKLEEGMVKNEKKEDIVCLICKKDY-------------RSPIATTCGHHFCEQCAITRYRKTPTCIQCGADTKGLFSVDKNFDRLLKNRKSKNDEAVKQKVGGFESNNSAT............................................................................................................. 334
31 -16.800[O] KOG1813 Predicted E3 ubiquitin ligase  ali follow..  247..............................................................................................................................................................................................................................................................................................................................RKRNKAMGVEDEDDEADKDSDEDENALPFACFICREPFV-------------DPVVTKCKHYFCEHCALKHHTKNKKCFVCNQPTMGIFNAAHEIKKRMAEERSKAEQGLRRLWPVGEVVPKSK............................................................................................................. 357
32 -16.400[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  23  246................................................................................................................................................................................................................................................................................................................FIAKKLYRKRKQEREEAKIRERLDTERRERRARSRPHTLSQDQLCVVCSTN-------------PKEIILLPCGHV--CLCEDCAQKISVTCPVCRGSI.................................................................................................................................................... 329
33 -16.400[O] COG5574 RING-finger-containing E3 ubiquitin ligase  ali follow..  13  221....................................................................................................................................................................................................................KIFEIYMDSDIFISCKEADQSHERTPELAERHLKWFDDQVRLAKCLPSSSKHRDRILYAKFLELNESLLKVASFMNKLAVTKIMKKFDKRTSLTAQPLFFQVIESDPLLLVDNASKAICFSLSSKLFSIIPQLRDECAICSNVAY-------------KPVRLGCSHVFCLHCLIILQKQKVDCPLCRAKEVMKADS.............................................................................................................................................. 408
34 -15.700[O] KOG2164 Predicted E3 ubiquitin ligase  ali follow..  16  166............................................................................................................................................................................................................................................................................................................KSRYVNANYRF--VSPIGDYQSQKLDPDSPVKEDVWQVLCSSDFQLAACPFCLEEK-------------VAARMSRCGHVYCFSCLLRFVETPTACPICWDSIRLRD................................................................................................................................................ 280
35 -15.600[S] KOG3899 Uncharacterized conserved protein  ali follow..  10  1.........................................MDESELLFNLFYILLCMVIILGFTIEQLFARFLGEEYLDHQRRTSLNLFVHSCLPFSYF------LIHRLKFSVFATQEPLEDFDLDPDFPMPQEAVAFKTLTWKTAQRFSVLAVLAMPALIFNWHISKALSKYSITPGSYSAVASEIGIEFRQPEIYKKKLNSISSVIATQNWIIKTTMYNVHFAHQSNTSLSVAKAETYNISHQDQNDT-------------------------LQMISIIVRPMRQGVSDFHIRINALEFRNLENRVRRPIAIPSNIQLHRNVIDRFVDVFKAQVAQNPIFPEKCFACMLNEPN-DRNGAPLANGACCSNCYCRPMWCVECLEVWLEQKCTCPMCRAKFCVLDVSYITTTVDATNSTQSQGTEEDTNDTT..................................................................................................................... 409
36 -15.400[DR] KOG4739 Uncharacterized protein involved in synaptonemal complex formation  ali follow..  10  6............................................................................................................................................................................................................................................................................................................................................................CNHCGIKP-----------NQTKLYLTACGHVFCQNCTKAAFNSQ--CYLCKKPLCKNAEAKKDTERFAEARSKHVEKTQEIEKRKKAFLEDNVKLKNAKEEKNQLMARLKELREQPSQNLSVNKRRSNTRTEPPFSKISRTGPPSVMRKASHEFSLNLRDQSTSKILTSTPLSNIDYSRRDHRNRLFGAGL-EHPSPILRQ. 240
37 -15.400[O] KOG3800 Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor  ali follow..  22  1..........................................................................................................................................................................................................................................................................................................................................................KECKKCKSNEYT--------NKQLVMMINECGHPLCKNCVNIFALNSGNCHVCNRVLRKNN................................................................................................................................................ 54
38 -14.700[R] KOG4299 PHD Zn-finger protein  ali follow..  239.................................................................................................................................................................................................................................................................................................................................EGRAEDISSNELLPTPEEYPYRYNNDYCSACHGNFLCCET---------------CPNSFHFTCIDAWY-----CNECKHHSLYNELDEQEELESNVKEEGTMVD............................................................................................................................. 336
39 -14.600[S] KOG3726 Uncharacterized conserved protein  ali follow..  351................SWERVSTEVRDYVYRQEARLEWALGLLHVLLSCTFLLVLHASFSYMDSYNHDIRFDNI--------------YISTYFCQIDDRRKKLGKRTLLPLR-----------KAEEKTVIFPCKPTIQASEMSNVVRLETLPILLLLVVLCGLDWALYSIFDTIRHHSFQYSFRSSHKLEVKVGGDSMLARLLRKTIGALNTSSETVMESNNMPCLPQPVGLDARAYW-----------------------------------RAAVPIGLLVCLCLLQAFGYRLRRVRILFLYNDLLKKRAAFTKLRRAAILRRERQQKAPRHPLADILHRGCRRCVVCQA---------PETPESYVCRTLDCEAVY---CWSCWDDMRQRCPVCTPREELSSSAFSDSNDDTAYAG.................................................................................................................................. 706
40 -14.100[R] KOG3612 PHD Zn-finger protein  ali follow..  10  787...........................................................................................................................................................................................................................................................................................................LSEMKHNLELTMAEMRQSLERDRLIAEVKKQLELEKQQAVDETKKKQ--CANCKKEAI-------------------CWNTSYCDCQQAWPEHMKSC---------TQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQGSDHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESRLDT......................... 992
41 -14.100[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  165................................................................................................................................................................................................................................................................................................................................RKIQRPVAYNPNATALKRKSRKVDMVTLCSVCQR------------GHSPLSNRI-CNSPYHQLCHAEWF-----CMKCQYRRAKQPLETGMTAQDLGLSESDKKMYLSSLPTPHLADLILFCEKSYPSLPIYNPRTRELLGEIRHQLLVSSERQQISLQERLHAKQDEAPSDEPAPVPYTASYVANSGTLYDYPTLIRLAIRNTLSPSKDEIFNWLAQNVPLLPTFHDSA 395
42 -13.800[DR] KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins  ali follow..  21  534.......................................................................................................................................................................................................................................................................................................................TLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDK-------------EVSVVFIPCGHLV-QECAPS-----RKCPICRGII.................................................................................................................................................... 609
43 -13.500[U] KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11  ali follow..  467VCRAANYHEHAMYVAKKAGKHEWYLKILLEDLGNYDEALQYVSSSQAGVTIEQYGKILIEHKPKETIDILMRLCTEQGIPNGVFLSMLPSPVDFITVFVQHPHSLMHFLERYAEIV--EINNTLLELYLSRDLNFPSISLSENGLDKDLIDHSVAAAVSKADPEKKTNADSKDAMEKDCTERQQKGLELLKMAWPSDLEQPLYDVDLAVILCEM---NSFKDGLLYLYEKMKFYKEVIACYMQNHDHEGLIACCKRLGDSSKGGDPS----LWADLLKYFGEVKEVLTYIERDDIPIIVLQTLCLTLSVIKDYIARKLEQESKIIEEDRRAVEKYQETTKNMRKQLSKCTACTFTL------------DIPAVHFMCMHSFHQRCLG---DNEKECPECYRSVMEMKRSLEQNSKDQDLFFQQVKGSKDG......................................................................................................................... 911
44 -13.400[U] KOG3799 Rab3 effector RIM1 and related proteins, contain Rab3a binding domain  ali follow..  28............................................................................................................................................................................................................................................................................................................GYAIKRVRQKDEEAKETQISQKASEELSELDKQITERKETSKKLVDAICQICQKTKFADGIGHK------------CFYCQLRSCARIWA-----CSLCQQQILAKTGKWFQPEEQPQPKISGSEPSPSPQPLTDDNVPEPQQRRAEPPDKMNTPNYQNNQQPRGMGMQPNHNQTQQNFMNQNQNSNQHPNQNHNQNQMQNPHQNQNHVQNNHQGANNHQQNNRRAMQQQPMSQNQANQI........... 269
45 -13.200[K] KOG2169 Zn-finger transcription factor  ali follow..  367....................................................................................................................................................................................................................................................................................................WAAGVYFVHRV--NSDILFKRLNQNVSRHRSLEVTKQEVIKKLSGGEDDIAMDRLNDPLCKTRM------------TTPSRCQDCTHL---QCLLSYLMMNEQCPVCSSNMLAKVDKNTTEDVIKEEAFCISDDDDDDVVPATVNGTASCSSTNGNGLANEAAKKKPADDDIITLSDDDDEELNRGIMNSLNDSFSPGRHTASAELAAQKTPPQQKKKTKDDDIEIITLDDTPPRPVAASANLPMRQ............ 630
46 -13.200[O] KOG1100 Predicted E3 ubiquitin ligase  ali follow..  23  271............................................................................................................................................................................................................................................................................................................................................GEAQDTKKMCRVGMSMCRSCGKG-------------EASVLLLPCRHM--SVC-----SSLNTCPICKSPK.................................................................................................................................................... 325
47 -13.100[U] KOG2066 Vacuolar assembly/sorting protein VPS41  ali follow..  11  370.............................ECKEEWEWAVNQFEEVKLCTLLAEVLPDGTPTLDPECYQKVLIACLFNNVKQFRKLV-RVLMDALAHLYLYERKYESALKILFNVIDKHQLFDLVKDQITELMNINSERALRLLLDNADSVEPSFVMEKIGRQPKLQLAYLTKLMSRNEGTEFADKAVQLYAEY---LLPFLRKNANYNVNARKLCSDKGYIEETIYLLAKSGNHYDAVKMMVREYRNMEKVIDYCKDQNDPDLWIH--LLGVVAEFPAHFSQLIIEASNCL----PLLIMDKLDSDIPNLSEALDKLLVDYTNHAELQQCCYDSTLNDLNVLTQGVSRCSLCAQIIINSNQETTKKFSD-----FKCGHIFHLACSTS--IEEGLCIACSDQ..................................................................................................................................................... 801
48 -12.800[U] KOG2034 Vacuolar sorting protein PEP3/VPS18  ali follow..  436FISINEPEALRTFLLHITMISTWATELYLDKINRL-DCKDELDEATTVKILESYELVYFANLKEQYEIVVLHYIQQGEAKKALEVL--LQYQFAPELIMLDAYETVESWMANKNLNPRRLITAMMRYSIKYLEFCVHRLHNEDPGIHSLLLSLYA----------DGALLRFLQCKFGKGRENGPEFFYDPKYALRLCLKRTRACVHIYSMMSMHEEAVALALQIDPELAMAEADKVEDDEDLRKKLWLMVAKHVVKQEKGAKRENIRKAIAFLKETDGLLKIEDILPFF---FALIDDFKE------AICSSLEDYNKQIEQLKEEMNDATRGADNIRNDISARDEECGVCKRKILMMSGDFRMAQGYSSAGPFPCGHSFHAQCLIT-LQKQSECPFCGELMINEITLPFIKPEDSQYSTSWDLRSETNLANQR.................................................................................................................... 988
49 -12.800[DKL] COG5220 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3  ali follow..  10  2.................................................................................................................................................................................................................................................................................................................................................DDEGARKVDEKCPLCQADRYLNPN--------KLLINPECYHKMCESCVDRIFTTGPATPGCNKIL----RKAKFREQTFEDAQIEREVDVRKRISRIFNKGQQEFDSLQAYNDYLEEVEILTFNLIYKIDVEETEEKVKQYEKQNRDSIAANSARAAAEARILAQNEILLKRQKQEAREAAIREHQKEKERREQVEQQIIFDLATSGKDPNKI 207
50 -12.700[R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  11  262................................................................................................................................................................................................................................................................................................................................RKRENRQIDGDETIWRKGHFKDLPDDLKCPLTGGLL------------RQPVKTSKCNIDFSKEALENALESDFVCPNCETRDILLDSLVPDQDKEKEVETFLKKQEELHGSSKDGNQPETKKMKLMDPTGTAGLNNNTSLPTSVNNGGTPVPPVPLPFGIPPFPMFPMPFMPPTATITNPHQADASPKK......................................... 441
51 -12.600[O] KOG4172 Predicted E3 ubiquitin ligase  ali follow..  33  1.................................................................................................................................................................................................................................................................................................................................................NGAQEVNEGDECTICMDA-------------PVNSVLYTCGHM--FECGRRLLTTKGTCPICRAPVQD.................................................................................................................................................. 56
52 -12.500[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  12  290..........................................................................................................................................................................................................................................................................................................................EELVSCSDCGRSGHPSCLQFTPVMMAAVKTYRKCCNICGT-------------SENDDQLLDCDRGYHMYCLTSW-----SCHLCLDLLKEKASIYQNQNSS....................................................................................................................................... 391
53 -12.500[B] KOG4718 Non-SMC (structural maintenance of chromosomes) element 1 protein (NSE1)  ali follow..  12  6.......................................................................................................................................................................................RRFLQLLMTHGVLEEWDVKRLQTHCYKVHDRSATVDKLEDFINNINSVLESLYIEIKRGVTELVNLATTSISKMATDFAENELDLFRKALELIIDS-TNILNLVDQLKGKKMRKKEAEQVLQKFVQLIEKEGEFTLHGRAILEMEQYIRETYPDAVKI-------CNICHSLLIQGQSCET------------CGIRMHLPCVAKYFQSNPRCPHCNDYWPHEIPKVFDPEKERESGVLKSNKKSLRSR....................................................................................................................... 254
54 -12.500[K] KOG3815 Transcription factor Doublesex  ali follow..  1......................................................................................................................................................................................................................................................................................................................................MNGY-GGPVSQPPRAPLQRTPKCARCRNH--------------LSWLK---GH-----C--RF--KDCTCEKCRQRVMAAQVALRRQQANESLESLIPDSLRALPGPPPPGDAVAAPQPPPASQPSQPQPPRPAAELAAAAALRWTAEPQPGALQAQLAKPDLTEERLGDGKSADNTEVFSDKDTDQRSSPDVAKSKGCFTPESPEIVS................ 199
55 -12.400[L] COG5627 DNA repair protein MMS21  ali follow..  136.................................................................................................................................................................................................................................................................................................................SDYGKYGTQGEYIEFKKTIWHEQNT-KTFFNVMNTEEQEADEVCPLTLQPIV------------HPILSTACNHFYEKDAILSLLNPTCVCPVCEARLQRSL................................................................................................................................................ 244
56 -12.200[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  15  792...........................................................................................................................................................................................................................................................................................................TDDIKLELDDEREKKKLEEELMELNKELEELGSESVEAAIVRLQEEVKNCGVCFDRP-----------KEVVIVK--CYHLFCQQCIQRSLERHRKCPGCGTAFGQND................................................................................................................................................ 893
57 -12.100[O] KOG2231 Predicted E3 ubiquitin ligase  ali follow..  21  21.................................................................................................................................................................................................................................................................................................................................GVANTTTDNAAVKPEALESYTGNDDNACVVCFKNVEIFS---------------DCDHPVCYECMRV-LCQQNECPICRHVL.................................................................................................................................................... 91
58 -11.900[OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger  ali follow..  43........................................................................................................................................................................................................................................................................................................................................GRYFGVSDDDKDAIKEAAPKCNNCSQRGHLKKDATDDHYSRHCPKAIQCGHY-HSRCPSIW-FHTIYCYNCRSSRVPNEDGSAFTGSNLSVELKQEYYRHMNRNSDENEDYQFSESIYDEDPLPRPSHKRHSQNDHSHSGRNKRRASNFHPPPYQKSNVIQPTIRGETLSLNNNISKNSRYQNTKVNVSSISENMYGSRYNPSTYVDNNSIS........... 321
59 -11.700[R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein)  ali follow..  13  155........................................................................................................................................................................................................................................................................QCRMLCMYAVPAQVEVREIISFMCISLPMIVSIKVVRDPAPNQYMLIIKFKEHNDAVTFYEEFNNCPFNDLESYCCTLFFVDRTCAVCLERMDDS--------------AILCNHSFHARCLEQW--ADNTCPVCR....................................................................................................................................................... 297
60 -11.100[R] KOG3002 Zn finger protein  ali follow..  15  6.......................................................................................................................................................................................................................................................................................................................SALKEALESNSTGVDYEVKMAKVEANSKPTKSGSGSICPVCTNLM--------------YPPIHQCGHTLCSSCKLR----QNTCPTCRYELGNIRCLALEK.......................................................................................................................................... 106
61 -11.000[S] KOG2660 Locus-specific chromosome binding proteins  ali follow..  2.............................................................................................................................................................................................................................................................................................................................................MIKVKKETMRAC--SCSICDNILRDA-------------------TTISEKCIYEKITEDEICPVCNIDLGSTPLEKLRPDHNLQDLRAKIFALKRRKVKAPGIVSLPGKRKERSISSLVVSTPMVSAQAGTTRRRTKAPTRKELRNGSLAERTVKKEESSGDELLESTSSPDTLNKFTQNKRQSKKSCKESISNKENKDGDEPWDSKMDWKPLNFLV 201
62 -11.000[R] KOG2979 Protein involved in DNA repair  ali follow..  208.......................................................................................................................................................................................................................................................................................................................HLMRQFREAVWNVHHAGEPMPGDDDEDIVMTSTQCPLCPLSGKPVTELADP---------VRSMDCRHVYEKSVILHYIVNNPNCPVCRGKLQNSKVICDAMLKFEIEEMRSLNKQSNRAEVIEDFTEDVDE............................................................................................................ 338
63 -10.700[O] KOG4185 Predicted E3 ubiquitin ligase  ali follow..  20  2........................................................................................................................................................................................................................................................................................................................................................SFIDCEICDEEFST-------LTDVNIPRILRCGHTTCHGCAEKLRNSTILCPFCREATNVSAVKDLQKNFALLQAVEHTKTKTEEKDSIDAPP................................................................................................................. 89
64 -10.700[B] KOG1973 Chromatin remodeling protein, contains PHD Zn-finger  ali follow..  18  251.................................................................................................................................................................................................................................................................................................................................EKESCHTAATHPSDVMDMPVDPNEPTYC-LCHQEMIGCDNPD-------------CPI-FHFACV-KWF-----CPKCTQD..................................................................................................................................................... 324
65 -10.700[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali follow..  11  443AYCKTWSYREDALLALSKKLMEMPVGTPKEDLKNTLRASVFLVRRAIKDIVTSVFQASLKLLKMIITQYI--KLSKLETAHCVERTIPVLLTRT------DSSARLRVTAANFIQEMALFKEVKSLQIIPSYLVQPLKANSSVHLAMSQMGLLARLLKDLGTGSSGFTIDNVMKFSVSALEHRVYEV-TAVRIILDMYRQHQASILEYLPPDDSNTRRNILYKTIFEGFAKIDGRATDAEMRARRKAATEEAEKQKKEEIKALQGQLAA------------------------------------EIQAEVQEKESDAVKPKNQDIQGGKAAPAEALGIPDEHYLDNLCIFCGERSESFTEEGLDLHYWKHCLMLRCEHLLHIDCNPA--KLANRCPLCKAHLMGPAGCTMNLRKTHILQKAPALQPGKSSAVAASGPLGSKAGSKIPTPKGGLSKSSSRT.......................................................................................... 921
66 -10.600[B] COG5034 Chromatin remodeling protein, contains PhD zinc finger  ali follow..  11  214.......................................................................................................................................................................................................................................................................................................................RPVRRSESRLKQTNGEPLVKHDTLDSSDISREGEQLYC-YCQQQMIGCDNEN-------------CKR-FHLPCV-IWY-----CKECEELAKSSESRQ............................................................................................................................................. 305
67 -10.600[R] COG5236 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  19  36................................................................................................................................................................................................................................................................................................................................RKQKKNNLSAEPNLTTSSADDTDEENELCVICARKLTYVS---------------PCHHKTCHICQRA-LYNKKSCLICRTEN.................................................................................................................................................... 107
68 -10.600[T] KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains  ali follow..  14  394.......................................................................................................................................................................................................................................................................WSFTELPV--SDRAQRFLRAV--------RESPVFRIRDLPGDLVKKNKALRAVVELRQKLKHMEGFIKICIDASNQVFEFGNIHCKKCRLVRCNDMTDRLFAFEERAVSRCECGHLSHSPKCPR-VPRDTHCPKCRLKTRANGGEFLDSEISGNLKRADVLGIFGNLKKAGTA.................................................................................................................. 612
69 -10.500[T] KOG0297 TNF receptor-associated factor  ali follow..  18  7.................................................................................................................................................................................................................................................................................................................................TPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVL-------------RRPFQAQCGHRYCSFCLASILSSGPQCAACVHEGIYEEGISILESSS....................................................................................................................................... 89
70 -10.500[O] KOG1815 Predicted E3 ubiquitin ligase  ali follow..  13  1................................................................................................................................................................................................................MDSEEDMLDAHDMESGEDDFYSGGTDDCNDSDDGEPDYGFVEEDADDSAMIASHRSQKNFCVLREEDIRRHQMDNIERVSVVL--SITEVEASILLRHFHWSVGRVHD--EWFADEERVRKTVGILESHVVPPSDDSELTCGICFDSY-----------PPEKIASVSCGHPFCTTCWTGYISTT-RCPDCLAAV.................................................................................................................................................... 191
71 -10.500[L] KOG1002 Nucleotide excision repair protein RAD16  ali follow..  10  357.......................................IILDEAHYIKERRSNTARAVFALEATYRWALSGTPLQNRVGELYSLIRFLQIR---------------YSYYFCKDCDCRILDYVAHQSCPHCPHNA----------------------VRHFCWWNKYVAKPITVYGSFGLGKRAMI-----------LLKHKVLKDIL----LRRTKLGRAADLALPPRIITLRRDTLDVKEFDYYESLYK------------NSQAEFNTYIE-----------------------TLMNNYAHIFDLLTRLRQAVDHPYLVVYSNS---SGANANLVDENKSEQECGLCHDPA-------------EDYVVTSCAHVFCKACLIGFSASKVTCPTCSKLLTVDWTTKADTEHKASKTTLKGFRASSILNRIKLDDFQTST............................................................................................................ 662
72 -10.400[K] KOG2068 MOT2 transcription factor  ali follow..  18  3......................................................................................................................................................................................................................................................................................................................................................DYGEKTCPLCAEEMDLTDQQ----------KPCKCGYQICVWCIMDMAEKDQSCPACRTPYDKEKIVGMTVDQERLASEGNMDRKKIQKSKPKSSDGRKPLTS.......................................................................................................... 102
73 -10.200[O] COG3058 Uncharacterized protein involved in formate dehydrogenase formation  ali follow..  10  140..........................................................................................................................................................................................................................................................................................................MASALFASDFSSVSSDKAPFIWAALSLYWAQMANLIPGKARAEYGEQRQYCPVCGSMPVSS-----QIGTTQGLRYLHCN------CETEWHVVRVKCSNCEQS..................................................................................................................................................... 235
74 -10.200[O] KOG4159 Predicted E3 ubiquitin ligase  ali follow..  30  6..................................................................................................................................................................................................................................................................................................................................................................................EPVTTPCGHSFCKNCLERCLDHAPYCPLCKESL.................................................................................................................................................... 38
75 -10.100[A] COG5183 Protein involved in mRNA turnover and stability  ali follow..  25  18.......................................................................................................................................................................................................................................................................................................................................KVANEETDTATFNDDAPSGATCRICRGE-----------ATEDNPLFHPCGSIMHESCLLEWVASKNICDICHYPI.................................................................................................................................................... 97

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Lesley SA, Kuhn P, Godzik A., Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor SS, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11664-9. Epub 2002 Aug 22.