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COG5243
Query: [O] COG5243 HRD ubiquitin ligase complex, ER membrane component, from COG0312

Results of FFAS03 search in COG0312
Master-slave alignment does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVPENRRKQLAIFVVVTYLLTFYCVYSATKTSVSFLQVTLKLNEGFNLMVLSIFILLNSTLLWQLLTKLLFGELRLIEHEHIFERLPFTIINTLFMSSLFHERYFFTVAFFGLLLLYLKVFHWILKDRLEALLQSINDSTTMKTLIFSRFSFNLVLLAVVDYQIITRCISSIYTNQKSDIESTSLYLIQVMEFTMLLIDLLNLFLQTCLNFWEFYRSQQSLSNENNHIVHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFTGLEGKFMYEKAIDVFTRFLKTALHLSMLIPFRMPMMLLKDVVWDILALYQSGTSLWKIWRNNKQLDDTLVTVTVEQLQNSANDDNICIICMDELIHSPNQQTWKNKNKKPKRLPCGHILHLSCLKNWMERSQTCPICRLPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGIPVKLTIENHEVNSLHGDGGEQIAKKIVIPDKFIQHILast
1 -143.000[O] COG5243 HRD ubiquitin ligase complex, ER membrane component  ali  100  1MVPENRRKQLAIFVVVTYLLTFYCVYSATKTSVSFLQVTLKLNEGFNLMVLSIFILLNSTLLWQLLTKLLFGELRLIEHEHIFERLPFTIINTLFMSSLFHERYFFTVAFFGLLLLYLKVFHWILKDRLEALLQSINDSTTMKTLIFSRFSFNLVLLAVVDYQIITRCISSIYTNQKSDIESTSLYLIQVMEFTMLLIDLLNLFLQTCLNFWEFYRSQQSLSNENNHIVHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFTGLEGKFMYEKAIDVFTRFLKTALHLSMLIPFRMPMMLLKDVVWDILALYQSGTSLWKIWRNNKQLDDTLVTVTVEQLQNSANDDNICIICMDELIHSPNQQTWKNKNKKPKRLPCGHILHLSCLKNWMERSQTCPICRLPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGIPVKLTIENHEVNSLHGDGGEQIAKKIVIPDKFIQHI 551
2 -93.300[O] KOG0802 E3 ubiquitin ligase  ali follow..  16  11ASTALSFVGLQVWTELSLDRLRADGLIAKNSLGDSEHALELLGSYFTIALLTNFVLNVYILLVLSLKTLFFGDLYDVETKKLVERLANYIIYTFLPLVIPPTIFGVLWTVWLTVLCTLKMFQALARDRLERLNA----SPSSTPWTYFRVYSVLFLVLSVDMFWIKLSLMTYNT------IGSAVYLLLLFEPCSIAFETLQALLIHGFQLLDMWINHLAVKNSDCQRSFIDSMTAGRFFSGVMLCFSIRARKCILVDIFGSLLEWKGLLNRNLGFFLDMATLVMYLHIWWLHGIAFHLVDNIRALLSAILKRIKGYIKLRIALGALHAALPDATSEELR---AYDDECAICREPM-------------AKAKRLHCNHLFHLGCLRSWLDQGYSCPTCRKPLFVGRTENEVNPRTVEVSSDEQLARQLERQNNPVHALATGLFPAEVPDSVENDTSRNLGLDPSWLQTWSSQGSDVAGPSTTSRTVGLGRVQMMMRHLASVGESYAQTALDDPSQASTSSTTVPPGNGGRTGGLHLRTVSNTTNESLTNI 563
3 -64.300[O] KOG1734 Predicted RING-containing E3 ubiquitin ligase  ali follow..  2...........................TFSYFISIFTANLSPTFPCRKVNQLNYFYQLLNLKCFFRSIFKIGHFPRGSPLYLLEKS-ITFSKIISIFSGHRMGQHGAIRLQNEVQEGMPPPHELTEEEQWAEEHRMHEKHKGHEAMHMEMMVIFMISVIVGQIFLVT-SYQMCTLIGMLTIPVYVCFNRSWYRFLATWLVFCIFSAFIWLKASAQHISGGTPRFVYKWFLFLHKLSYVLG-----------------------------VVGYLIMMGALLGFHVLFGVSQPTLMDAGILFMFYGVYYGVLGRDFAHICTARMASRIGYYTPEGLPKKHLEDGVHDADAVVTTKMVE---------DEDEKLYKLSCGHVFHEFCIRGWVVKLQTCPYCKERVDLQRMFKNPWEKPH...................................................................................................................................... 375
4 -45.400[O] KOG0828 Predicted E3 ubiquitin ligase  ali follow..  11  387TRYELKIMSIRKHLLFGIALFAAQIYLLLTQMHH-------TNTPSMVNKISFYCFSMINLVDGSLATLYF--VAASVVPELYLPLVISAFSCFILASIFEIRYLISIYASQVNEQNVGIINLLRGNTGTYDENRPRPAFIPDEGSIGGSLYGRFFFMLIIFTFLILSSTSWPRQLRMVFEYILIFILNSYWIPQIFRNAVKGIPSRRERARSSIGGNRSQNKMPLLWSFVIGTTIIRSLPV------------------------VYVFTYSSNVFRHHKDVHFVVFLSLWLLFQISILYSQDVLGSRWFLPKHTIPDGYSYFKPLSNEYIS---EHGGGTAEHTVDCAICMSDVPIYIEEPETHKVDQHSYMVPCNHVFHTSCLENWMNYKLQCPVCRSPLPP.................................................................................................................................................. 757
5 -42.300[O] KOG4628 Predicted E3 ubiquitin ligase  ali follow..  10  7...........................................................................................................QILTLLGLCLVCHEATLVGGHVLVYRKATSQLIEEFNDLPAQFGPNLPSNGLKVYVVPARGCDSLDRPPHLKYPPSAKFVALVARGECVFERKIRVAQNASYSAVIVYNNEGDDLEQMSAENITGIRIPSVFVGHTTGKALATYFTTEVVLIINDELPFNINTQLILPFSILIGMCFIIMVIYMIYKC-----------------REQRRLRRHRLPKSMLKKLPVLRYTKNNANNKYDT-CVICLEDF----------IEDDKLRVLPCSHPYHTHCIDPWLTENRVCPICKRKVFTKGEARASRSRQPSLDNVTDTDDDTTPLLQQQQSNGRQVGQVSSASSAGGAAGSSSSVAAAAVAGTTRHGTFRRGHAGRNPFEESQSSDDENALLASTVRPATSSGAHERINPFDRAPNLPAHLAEQLTESRRSVWSRINFASFFR. 427
6 -40.500[O] KOG0800 FOG: Predicted E3 ubiquitin ligase  ali follow..  26................................................................................................................................................................................................................................................................................FIFSVPICFTFIILFLFYLIYLRRSSSDLSSLGMRTTFIPGNSLSTIELGLSKELREMLPIVVFKESFTVMDSQ--CSVCLGDY----------QPNDKLQQIPCKHTFHMDCIDLWLTSHTTCPLCRLALIPSRSRQSQDDPVPSLVSPDEEVSSQPESEPVNHRVVSTQPESEPVNHSGVSSQPESQPVVNHRGVSSQPESQPVNHINDGHEQQCDQDVEGFKEMEEDERNNIGTSSACCSCRTVHYCCVSRDNQIMYAYNNAGDHRNNESLAALCL 293
7 -39.500[O] COG5540 RING-finger-containing ubiquitin ligase  ali follow..  10  2.................................SYYQIIVCILASISYIILLEVIALDLGVLDNIFIPKRFAASTDVAIQLPDRNVTLWSRQAVFGKHFTNASATTVINLYLPSNF---------QEDMSGCPNRNDTDASYFYENDIIDYDIEYIEQKSYSSKPSARVQKDDGGESKDEAILDFLLV-TYFDKALEAQRLGFKGVIVGDNRSPSSFRLHYMVAPDKVDESKVHIPSLFVSTSSYNLLWSDLLHSYRQPLKLYAKPEELGDMFWPFLLCFSPSIIMLITVQALAIRKFIRTYRTKSKTR-REGFYSEEEEIENSTQNGELVPLMDEST--RRATFGVECVICLESF----------TKGDKVVALPCKHEFHRPCIAKWIDYRHACPTCNTEVPPPKP............................................................................................................................................... 371
8 -39.300[O] KOG0801 Predicted E3 ubiquitin ligase  ali follow..  24  149..........................................................................................................................................................................................................................................................................................................................SKSVASDEMEMHFIMCLSKPRLSYNDDVLTKDAECVICLEELL----------QGDTIARLPCLCIYHKSCIDSWFEVNRSCPEHPAD..................................................................................................................................................... 227
9 -35.700[S] KOG4445 Uncharacterized conserved protein, contains RWD domain  ali follow..  12  66..................................................................................................................................................................................................................................................................................................................LEAIRSACNAKIK-ESIGFPVVFDLIEVVREHLSGSNLPSGQCVVCLYGF----------ADGDEFTRTECFHYLHSYCLARHLNAQALCPVCREHIGDETDSLKCAMPPSELLNAPEFKVTEELRQMQQRMSELYLQQKSRGAIIDVNAEGSAVISIETEEDIRRRRRREEAEAAKKLEGPSKEEVIKPTTSSTFAPVVQETHRIMPEPTNNNYHHNRRHYRGGRRHHHHHQHGHHHRAERER. 321
10 -34.700[O] KOG0827 Predicted E3 ubiquitin ligase  ali follow..  11  3.........................................................................................................................................................................................................................................................................................................................................................NLNCVICAELF----------GQADEVFATVCGHMFHHNCLNQWLDRSKTCPQCRNKCTTRNIFRVYFNLANLDVSHIDVGSLQEQLDNAMLSMKMVEKERNKDEQQIRDLKETQKKCLKTIAGLEQKVQKKDFLISSYVEKSDAHVVDGLRKENKTLKSQIQSMEGISAILAAGSADADRLLKNEADPHVLANWVSTLKRELRQC 203
11 -34.500[O] KOG3970 Predicted E3 ubiquitin ligase  ali follow..  11  30.....................................................................................................................................................................................................................................................................................................................................DNHPNCVVQSYLTWLTDQDYDPNCSLCKTTL----------AEGDTIR-LNCLHLLHWKCFDEWAANFPRCPCCSQEVFPPINEVSPLIEKLREQLKQSNWARAALGLPTLPELNRPVPSPAPPQLKNAPVMHKEVPVHNNRSSTPATHLEMEDTASYSVSNNDVTFARKKNYGAESSSDTRPLLQLRDADNEENKYKRRPTMDWMRGLWRAKHGGSGVPQE.... 248
12 -28.800[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  18  229.......................................................................................................................................................................................................................................................................................................................LPRRSAENDPVVDLDVASPPKRVNRDIDESQKEELYKCPICMDSVSKRE-----------PVSTKCGHVFCRECIETAIRATHKCPICNKKLTARQ................................................................................................................................................ 313
13 -28.500[O] KOG0823 Predicted E3 ubiquitin ligase  ali follow..  11  75...................................................................................................................................................................................................................................................................................................................AGVIHERSRERLVENGENKTYLIAKALNMEKTSSVPGGFFDCNICLEKA-------------EDPILTCCGHLFCWGCFYQLPLIYLECPVCDGEVTDAEGDDCDGTKPKLEDCGISLPPRPNAKRVESVRQKATFPGLLVDTSDIPAPFDDDAFDVDSFVDTTSLRRNRRRPSPAVRASYQRNRSNNASQTISFRLGSSASSAPREFAVPSSSIMTRSQTVNPTEVVTSSTSASSSRRRTEDV 391
14 -28.100[O] KOG2930 SCF ubiquitin ligase, Rbx1 component  ali follow..  15  1.....................................................................................................................................................................................................................................................................................................................MEVDEDGYEVPSSSSKGDKKRFEVKKWNAVAAWDIVVDNCAICRNHIMDQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWDFQK................................................................................................................................................ 105
15 -27.000[O] KOG3268 Predicted E3 ubiquitin ligase  ali follow..  1........................MAVTEASLLRQCPLLLPQNRSKTVY---------FISAQGRDFHL---RIVLPEDLQLKNARLLCSWQLRTILSGYHRIVQQRMQHPPDLMSFMMELKMLLEVALKNRQELYALPPPPQ--FYSSLIEEIGTLGWDKLVYADTCFSTIKLKAEDASGREHLITLKLKAKYPAESPDYFVDFPVPFCAS------------TPQSSLISIYSQFLAAIESLKAFWDVMDEIDEKTWVLEPEKPPRSATARRIALGNNVSINIEVDPRHPTMLPECFFLGADHVVKPLGIKLSRNIHLWDPENSVLQNLKDVLARAILEKSDFTMDCGICYAYQLDGTIPDQVCDNSQ------CGQPFHQICLYEWLRGLLECPYCSKPITLKMSGRKH........................................................................................................................................... 375
16 -26.100[O] KOG1813 Predicted E3 ubiquitin ligase  ali follow..  241........................................................................................................................................................................................................................................................................................................................EEAEKVRKRNKAMGVEDEDDEADKDSDEDENALPFACFICREPFV-------------DPVVTKCKHYFCEHCALKHHTKNKKCFVCNQPTMGIFNAAHEIKKRMAEERSKAEQGLRRLWPVGEVVPKSK............................................................................................................. 357
17 -26.000[L] KOG0287 Postreplication repair protein RAD18  ali follow..  12  1......................................................................................................................................................................................................................................................................................................................................MDHQITTASSIPSLYQLDTLLRCHICKDFL-------------KVPVLTPCGHTFCSLCIRTHLNNQPNCPLCLFEFRESLLRSEFLVSEIIQSYTSLRSSLLDALRIPKPTPVPENEEVPGPENSSWIELISESESDSVNAADDDLQIVATSERKLAKRSMTDILPLSSKPSKRNFAMFRSERIKKKSKPNEQMAQCPICQQFYPLKALEKTHLDECLTLQS.. 215
18 -26.000[T] COG5432 RING-finger-containing E3 ubiquitin ligase  ali follow..  12  1......................................................................................................................................................................................................................................................................................................................................MDHQITTASSIPSLYQLDTLLRCHICKDFL-------------KVPVLTPCGHTFCSLCIRTHLNNQPNCPLCLFEFRESLLRSEFLVSEIIQSYTSLRSSLLDALRIPKPTPVPENEEVPGPENSSWIELISESESDSVNAADDDLQIVATSERKLAKRSMTDILPLSSKPSKRNFAMFRSERIKKKSKPNEQMAQCPICQQFYPLKALEKTHLDECLTLQS.. 215
19 -25.300[OD] COG5194 Component of SCF ubiquitin ligase and anaphase-promoting complex  ali follow..  14  25................................................................................................................................................................................................................................................................................................................................SAPVETKKKRFEIKKWTAVASWDIAVDNCAICRNHIMEPCIEAMTDTDNECVAAWGCNHAFHLHCINKWIKTRDACPLDNQPWQLAR................................................................................................................................................ 118
20 -25.300[O] KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein  ali follow..  11  29.........................................................................VQAHQKDQIQGLLIMKVTELCKLIK-YPKELSIFAKLLYLLFTTGRRGRTLGEE-LTYTNRKGTRLAGRLK----MIVFAFAYPLC---YFITKLYKKIMKNNKESKIEDTESVAAFCKGLLDFILDVHMTLFYFKGAF-----------------------YSISKRIFGMRYVFKHILSKNEANFREEGSQKYKVLGYILLAQNVMKWYPVLTSTLGSWIYGRKRTNITRSSVGLQERSEHESIEGIPKESQLTHINLSDKNQLPFIPEASRKCILCLMNMS-------------DPSCAPCGHLFCWSCLMSWCKERPECPLCRQHCQPQE................................................................................................................................................ 331
21 -25.300[R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers  ali follow..  219....................................................................................................................................................................................................................................................................................................................QLDREWDSVQEKYKKGAKLEEG-----MVKNEKKEDIPFVCLICKKDYR-------------SPIATTCGHHFCEQCAITRYRKTPTCIQCGADTKGLFSVDKNFDRLLKNRKSKNDEAVKQKVGGFESNNSATTEVSERKDREASFQGFADTLAKPNTSAQQKMPSLGDNSNTIISKYFIREITESNIVHFKR................................................. 394
22 -25.100[O] KOG4265 Predicted E3 ubiquitin ligase  ali follow..  17  243.........................................................................................................................................................................................................................................................................................................................VDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSD-------------LRDTLILPCRHL--TSCADTLRYQANNCPICRLFPGPPADPGGAEEARSPVPRVLQPRPGPEPGA...................................................................................................................... 350
23 -24.400[DO] KOG1493 Anaphase-promoting complex (APC), subunit 11  ali follow..  20  37.......................................................................................................................................................................................................................................................................................................................DHPGILLKTNTRMSITVKKLHVCGEWKWLQGGEDT--CGICRMEFESACNM--KFPGDDCPLVLGCRHAFHRHCIDKWIQPRAQCPLCRQDWTIVE................................................................................................................................................ 135
24 -24.300[S] KOG4638 Uncharacterized conserved protein  ali follow..  130.......................................................................SPYQRYDIQQAARWIEQILFSLLLLVVFIRQHLQGFFVAIWIAAVMFKSNDILKK-------QTALKGERHISALIGISVAFTAHVVGVYWWFRKDDLLYPLIMLPPKSIPPFWHAIFIIVYPVGSFGAYSLVPIFLRYTCPAGLNDFQGQ----------------------LTLVEYFMLLYRSLLPTPVWYRFFLNKDYGSLFSSLMTGLYLTF-----------LTSVVEKLREIGNEIQVQSFFTALKALSRKEVHYGSYATTEQATCVPSARRRCTPQFFFAANT-------FAKIAFQSGEVFLHIAIIFVYEYLD-----VERM.................................................................................................................................................... 413
25 -24.000[O] KOG3800 Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor  ali follow..  10  1..........................................................................................................................................................................................................................................................................................................................................................KECKKCKSNE--------YTNKQLVMMINECGHPLCKNCVDNIFALNSNCHVCNRVLRKNNRFKNFKNFFYEFSIRYSNSPSFSWSNPEFSAQNSKIAPSNSKFQFFRFETVVYNLVFETNVNETNAEIQAFEEKHKEQIDRNKRRLDDDQKWIEDQLREERAMKARMTDHMEMDAKEQEAASAVTDTRKIMDELRDSNVAAEVI 260
26 -23.300[O] KOG4692 Predicted E3 ubiquitin ligase  ali follow..  11  68LGIHSADPRIVLASCKDSLLQA---LGTLTCHKSGVRALERTSKRSQASLVRALL--AWGQSNWLLLRFWMGEYKDSRQPSVWQG---KHFQRLIGAKLLEDEPFAT--AFLNSVLAFSEFILLLQEIQNTAQRQENTLFEPKQLKICSMCFELTVSLMRCLEMVITTAPEIVTDESRPNSDLLLLISQVLSRVTVPPGCFQFVVDIVTAALGILLALMQEEMESDLRPQIVTRVSRAFLTDPSFQFATLEFALGEIRTPLLEQKNIPRGNFDPSSRPHIDPLTNDVRVPLPNNSKRIRADPPILKFALNDFPSHVSSEEIDNVRRLIDSLRVKTLLSDITLPSEDSLCPICCAKPI-------------TAVFTPCKHQSCSDCIMQHMMNSKVCFYCKTTIQTIETLDGTVIFSNDDVVQTPMIERA.......................................................................................................................... 538
27 -23.100[DR] KOG4739 Uncharacterized protein involved in synaptonemal complex formation  ali follow..  2........................................................................................................................................................................................................................................................................................................................................................DWIQCNHCGIKPN-----------QTKLYLTACGHVFCQNCTKAAFN--SQCYLCKKPLKVDEINKNLRPDLMELFKDPRQLASDLVNELKQVVAFQAKQREIYVKCKNAEAKKDTERFAEARSKHVEKTQEIEKRKKAFLEDNVKLKNAKEEKNQLMARLKELREQPSQNLSVNKRRSNTRTEPPFSKISRTGPPSVMRKASHEF. 194
28 -23.000[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  22  604...........................................................................................................................................................................................................................................................................................................VKQLKEVLMLHRVDYKGCCEKQELLDRVSRLWKTMRECPAVEKLATDELCKICMDA-------------PIECVFLECGHM--TSCGKV-LNE---CPICRQYIVR.................................................................................................................................................. 693
29 -22.700[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  12  1......................................................................................................................................................................................................................................................................................................................................MNASTSSPSQQLQQAINSTIDECAVCYSEMI-------------LPTTIPCGHKFCFICLKGVSVSNNDCPICRGPI---DSQIFKKPLQAVDLKMDIPGTPSAAAPDPVVKQEVDDEDVKPDVKKLQEELKKQQAAAAAQKMFWLYRGRHQGWWRFDPRIEKEIEEAFTHQMPMTEVTICGNPYIVDFSQMCQYPKNQSNYSRNVKRVNSTDFDSLNVKGMSGV 212
30 -22.700[R] COG5219 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  11 1200LLKRFLFTHESTLRNSVTARMCNQYLVKLLENCPGKVVRSFQYQEFFPSLCNSNDLQMESVCMKFLREKL--YYMVESDYEPDVSLCPELLSLAIMVSKMEKYEHALRVYLLVWDLIFYHFEETTYNKLSIINQLHAMDLLRP------LNTLVEILNLSYDRPINVDKYPKIDYNLMDYSSATD------RIRCLAIHIYYQCLRHLSSSVRSYWSEVKNRAFTSTVESFTGYNVSPLLISASLDDVERSIESEDFQSVGDVNVKVNRNTREISFIYNVDEHKLEMAIKIPSVYPLQNVQ--VEGIERVGVNERQWRSWILASQSILSSQNGSITDNISMHFEGVEECAICYSVLSVER-------------TLPCRHKFHASCLYKWFKSSSRCPLCRSSF.................................................................................................................................................... 1607
31 -22.700[B] KOG4718 Non-SMC (structural maintenance of chromosomes) element 1 protein (NSE1)  ali follow..  12  7........................................................................................................................................................................................RFLQLLMTHGVLEEWDVKRLQTHCYKVHDRSATVDKLEDFINNINSVLESLYIEIKRGVTEDDGRPIYALVNLATTSISKMATDFAENELDLFRKALELIINILNLVDQLKGKKMRKKEAEQVLQKFVQNKWLIEKEGEFTLHGRAILEMEQYIRETYPDAVKICNICHSLLIQGQ------------SCETCGIRMHLPCVAKYFQSNARCPHCNDYWPHEIPKVFDPEKERESGVLKSNKKSLRSRQ...................................................................................................................... 255
32 -22.200[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  64...................................................................................................................................................................................................................................................................................................................ERQTREYIDVLDSPVRVSQNESEGIENQNRRMSNGNKVTLRDCLVLSVWKFGP----------AVANTKSGILDSIVFPVDTCMDISGFSSDEVEIYASRVAAVDDEAHKRILFLEAKLRSIEQKTASWSNKEVQWKITEAELRLEVTKLKKKIANMESTTKGSQSQSNVASQEKYIPAHNIYQEHHGQSPS.................................................... 257
33 -22.000[K] COG5175 Transcriptional repressor  ali follow..  11  11.................................................................................................................................................................................................................................................................................................................................QAIHNALSNFDTSFLSE-----DEEDYCPLCIEPMDITD---------KNFFPCPCGYQICQFCIRQNPELNGRCPACRRKYDDENTRSGIHNNISTSTAGSNTNLLSENFTGTPSPAAMRAQLHHDSHTNAGTPVLTPAPVPAGSNPWGVTQSATPVTSINLSKNSSSINLPTLNDSLGHHTTPTTENTITSTTTTTNTNATSHSHGSKKKQSLAAEEYKDPYDALGN. 425
34 -22.000[O] KOG0826 Predicted E3 ubiquitin ligase involved in peroxisome organization  ali follow..  17.....................................................................IFEISASETLDNLIYPALSKIFDYFGLRLDFKLWGSLRIQEELSPLLTWLLQYLYLRKRASSFGESFYGLQRTVTTTGDLLNRRQQFASATLLTFMPYVERKLRTRITRHEDTSPWELLSAFHAFHAAKAAHTFFYLVKYASN------------------------------------------------------HSPIFRLLGLTLRYPSEPPKEDQWTYVVLKMLEVLAFFLQFVQWWYSNDQRRKVGGTLINPEAMPRKQLPKEVQQSLPQRGECPVCLLSIQ------------TPTACSVSGYVFCWKCIVSHMKEHGTCPVTHYPISLDD................................................................................................................................................ 290
35 -21.400[O] KOG2879 Predicted E3 ubiquitin ligase  ali follow..  52....................MSAMLKEQLVKVFTLMKPGMLFQYEPELDAFLEFLIWRFSIW---VDKPTPGN----ALMNLRYRDERGVVAQHLGKGLEGPGLTSPQKIWYCVASVGGQY---LFSRLQSFSAFRRWGDSEQRPLARRLWTLVQRIEGI------------------------YKAASFLNLLSFLYTRYRNLIEKALKARLVYRSPHMNRSVSFEYMNRQLVWNEFSV------------------------------GLLYPSIDQNILFRLATRNVMLGSDFLVLFWHSALNLFGDIQEMLLLLLPLLNSSAVKNILSPFAKDKSSSTKEDTVTCPICQVDPAIPFIALPCQHS--IHLKELTCRRYCYYCIRTRCASAARCLRCNEPVVAIQREGVSSGK........................................................................................................................................ 389
36 -21.200[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  23  247.................................................................................................................................................................................................................................................................................................................IAKKLYRKRKQEREEAKIRERLDTERRERRARSRPHTLSQDQLCVVCSTN-------------PKEIILLPCGHV--EDCAQ---KISVTCPVCRGSIVS.................................................................................................................................................. 331
37 -21.100[O] COG5574 RING-finger-containing E3 ubiquitin ligase  ali follow..  22  319...................................................................................................................................................................................................................................................................................................................PLFFQVIESDPLLLVDNASKAICFSLSSKLFSIIPQLRDFECAICSNVAY-------------KPVRLGCSHVFCLHCLIILQKQKVFCPLCRAKEVMKADS.............................................................................................................................................. 408
38 -20.700[O] KOG2164 Predicted E3 ubiquitin ligase  ali follow..  170..............................................................................................................................................................................................................................................................................................................VNANYRFVVSPIGDYQSQKLDPDSPVK---EDVWQVLCSSDFQLAACPFCLEEKP------------VAARMSRCGHVYCFSCLLRFVETPTACPICWDSIRLRDEDKEFQKLEEGKSVCLRLYQRNNGSILAFPRSCRSFALDGSFHSDEIPNFTMSGAAYARIIIGSHDYMVQQHLLEIEQLQQIAAEDISLYGSADTYYERITQILLDRISSLSESVNEQNIKSLQTDIDNLCLQSNSLKQLSEV. 430
39 -20.600[O] KOG1100 Predicted E3 ubiquitin ligase  ali follow..  21  262...................................................................................................................................................................................................................................................................................................................................SEEERWKLAGEAQDTKKMCRVGMSMCRSCGKG-------------EASVLLLPCRHM--SVC-----SSLNTCPICKSPK.................................................................................................................................................... 325
40 -20.000[R] KOG4299 PHD Zn-finger protein  ali follow..  229.......................................................................................................................................................................................................................................................................................................................GNESENFNDMEGRAEDISSNELLPTPEEYPYRYNNDYCSACHGNFLCCET---------------CPNSFHFTCIDPWY-----CNECKHHSLYNELDEQEELESNVKEEGTMV.............................................................................................................................. 335
41 -19.900[DKL] COG5220 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3  ali follow..  10  2.................................................................................................................................................................................................................................................................................................................................................DDEGARKVDEKCPLCQADRYLNPN--------KLLINPECYHKMCESCVDRIFTTGPATPGCNKILRKAKFREQTFEDAQIEREVDVRKRISRIFNKGQQENLIYKIDVEETEEKVKQYEKQNRDSIAANSARAAAEARILAQNEILLKRQKQEAREAAIREHQKEKERREQVEQQIIFDLATSGKDPNKIIQLSDSLKKQQENIASSVS.... 226
42 -19.600[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  152...................................................................................................................................................................................................................................................................................................................EDFHVEGMKTKSGRKIQRPVAYNPNATALKRKSRKVDMVTLCSVCQR------------GHSPLSNRI-CNSPYHQLCHHPWF-----CMKCQYRRAKQPLETGMTAQDLGLSESDKKMEKSYPSLPIYNPRTRELLGEIRHQLLVSSERQQISLQERLHAKQDEAPSDEPAPVPYTASYVANSGTLYDYPTLIRLAIRNTLSPSKDEIFNWLAQNVPLLPTFHDSASEAIRWMVNKGQLVRS. 411
43 -19.300[R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  10  253.......................................................................................................................................................................................................................................................................................................................DKQSWEDYQRKRENRQIDGDETIWRKGHFKDLPDDLKCPLTGGLLR-------------QPVKTSCNIDFSKEALENALVESDVCPNCETRDILLDSLVPDQDKEKEVETFLKKQEELHGSSKDGNQPETKKMKLMDPTGTAGLNNNTSLPTSVNNGGTPVPPVPLPFGIPPFPMFPMPFMPPTATITNPHQADASPKK......................................... 441
44 -19.200[S] KOG2660 Locus-specific chromosome binding proteins  ali follow..  10  1.............................................................................................................................................................................................................................................................................................................................................MMIKVKKETMRACLSCSICDNILRDA-------------------TTISEKCIYEKITEDEICPVCNIDLGSTPLEKLRPDHNLQD-ALKRRKVKAPGIVSLPGKRKERSISSLVVSTPMVSAQAGTTRRRTKAPTRKELRNGSLAERTVKKEESSGDELLESTSSPDTLNKFTQNKRQSKKSCKESISNKENKDGDEPWDSKMDWKPLNFLVEVAN. 205
45 -18.200[K] KOG2169 Zn-finger transcription factor  ali follow..  367....................................................................................................................................................................................................................................................................................................WAAGVYFVHRV--NSDILFKRLNQNVSRHRSLEVTKQEVIKKLSGGEDDIAMDRLNDPLCKTRMTT-------------SRCQDCTHL---QCLLSYLMMNEQCPVCSSNCPYDR--KEDGSYDVIKEEAFCISDDDDDDVVPATVNGTASCSSTNGNGLANEAAKKKPADDDIITLSDDDDEELNRGIMNSLNDSFSPGRHTASAELAAQKTPPQQKKKTKDDDIEIITLDDTPPRPVAASANLPMRQMSQQNQMP.. 638
46 -18.100[U] KOG3799 Rab3 effector RIM1 and related proteins, contain Rab3a binding domain  ali follow..  22.........................................................................................................................................................................................................................................................................................................EHTQNNGYAIKRVFKRQKDEEAKTQISQKASEELSELDKQKKLVGTQDDAICQICQKTKFADGIGHKCFY---------CQLRSCARC-AIWA-----CSLCQQQILAKTGKWFQPEEQPQPKISGSEPSPSPQPLTDDNVPEPQQRRAEPPDKMNTPNYQNNQQPRGMGMQPNHNQTQQNFMNQNQNSNQHPNQNHNQNQMQNPHQNQNHVQNNHQGANNHQQNNRRAMQQQPMSQNQANQINQMNQNQNQQ. 279
47 -17.200[S] KOG3899 Uncharacterized conserved protein  ali follow..  11  1.........................................MDESELLFNLFYILLCMVIIYGFTIEQLFARFLGEEYLDFVGYHQRRTSLNLFVHSCL----------FSYFLIHRLKFSVFATQEPLEDFDLDPDFPMPQEAVAFKTLTWKTAQRFSVLAVLAMPALIFNWHQENWRRHPISKALSKYSITPGSYSAVASEI-------IEFRQPEIYKKKLNSISSVIATQNWIIKTTMYNVHFAHQSNTSLSVAKAETYNISHQDQNDTLQMISIIVRPMRQGVSDFHIRINALEFRNLENRVRRPIAIPSNIQLHRNVIDRFVDVFAQVAQNPIFPDDATTEKCFACMLN-ADFDRNGAPLANGACCSNCYCRPMWCVECLEVWLEQKCTCPMCRAKFCVLDVSYITTTVDATNSTQSQGTEEDTNDTT..................................................................................................................... 409
48 -17.100[L] COG5627 DNA repair protein MMS21  ali follow..  145............................................................................................................................................................................................................................................................................................................GEYIEFKKTIWHEQNTDGSDFPSMKTFFNVMNTEEQEADEVMVYSDNRCPLTLQPIV------------HPILSTACNHFYEKDAILSLLNPTCVCPVCEARLQRSLLKEDEILERRLRRAQEISNLKEA......................................................................................................................... 267
49 -16.900[R] KOG3002 Zn finger protein  ali follow..  19  20.......................................................................................................................................................................................................................................................................................................................DYEVKMAKVEANSKPTKSGSGSIGKFHSSNGVYELLECPVCTNLMY------------PPIHQCPNGHTLCSSCKL---RVQNTCPTCRYELGNIRCLALEKVAES...................................................................................................................................... 110
50 -16.400[K] KOG3815 Transcription factor Doublesex  ali follow..  12...........................................................................................................................................................................................................................................................................................................................................GGPVSQPPRAPLQRTPKCARCR------------------------NH--HKRC--RF--KDCTCEKCRQRVMAAQVALRRQQANESLESLIPDSLRALPGPPPPGDAVAAPQPPPASQPSQPQPPRPAAELAAAAALRWTAEPQPGALQAQLAKPDLTEERLGDGKSADNTEVFSDKDTDQRSSPDVAKSKGCFTPESPEIVSVEEGGYAVQKNG.... 211
51 -16.300[O] KOG4185 Predicted E3 ubiquitin ligase  ali follow..  11  1.......................................................................................................................................................................................................................................................................................................................................................MSFIDCEICDEEFSTLTDV-------NIPRILRCGHTTCHGCAEKLLRNSTLCPFCREATNVSAVKDLQKNFALLQAVEHTKTKTEEKDSIDAPPGAHAGHKKGLLQSEAAKLRQFLSGKLSRSEELASQIETNIEKIG--RAQLTNIDDGEVFQEKKDSIVSYYTTLRMTLDALENEALEKLQNIAEANFSRNEILVAELSESLEKQ 233
52 -16.200[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  15  313...........................................................................................................................................................................................................................................................................................................................................MMAAVKTYRWQCIECKCCNIC-------------GTSENDDQLL-CDRGYHMYCLTPWS-----CHLCLDLLKEKASIYQNQNSS....................................................................................................................................... 391
53 -16.100[U] KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11  ali follow..  467VCRAANYHEHAMYVAKKAGKHEWYLKILLEDLGNYDEALQYVSSSQAGVTIEQYGKILIEHKPKETIDILMRLCTEQGIPNGVFLSMLPSPVDFITVFVQHPHSLMHFLERYAEIV--EINNTLLELYLSRDLNFPSISLSENGLDKDLIDHSVAAAVSKADPEKKTNADSKDAMEKDCTERQQKGLELLKMAWPSDLEQPLYDVDLAVILCEMNSFKDGLLYLYEKMKFYKEVIACYMQNHDHEGLIACCKRLGDSSKGGDPSLWADLLKYFGEEVKEVLTYIERDDILPPIIVLQTLAKNPCLTLSVIKDYIARKLEQESKIIEEDRRAVEKYQETTKNMRKELSKCTACTFTL------------DIPAVHFMCMHSFHQRCLG---DNEKECPECAPEYRSVMEMKRSLEQNSKDQDLFFQQVKGSKD....................................................................................................................... 910
54 -15.000[S] KOG3113 Uncharacterized conserved protein  ali follow..  96...................................................................................................................................................................................................................................................................................................................................NPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMN---------GRHRFCFLRCCGCVFSERALKE---KAEVCHTCGAAFQEDDVIMLNGTKEDVDVLKTRMEERRLRAKLEKKTKKPKAAESVSKPDVSEEAPGPSKVKTGKPEEASLDSREKKTNLAPKSTAMNESSSGKAGKPPCGATKRSIADSEESEAYKSLFTTHSSAKRSKEESAH............... 297
55 -15.000[R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein)  ali follow..  235...................................................................................................................................................................................................................................................................................................................................VDRIECTTSNDLFSSDDTSLTELPTCAVCLERM------------DDSVLAILCNHSFHARCLEQW--ADNTCPVCRYVQSPEVVAEQRGRYAEQHAQRHWELTSHTYSLKVGGERVWDYAGDNYVHRLIENGADGKLVEYQRESNASFDDKNQKGGDKLEGIKLEYTLLLTSQLEDQRKYFEGLRHDMEQTMSKMEKTAYAQVENLEHQLTERSTELKSLKGDLDDT 469
56 -15.000[R] KOG2979 Protein involved in DNA repair  ali follow..  12  187............................................................................................................................................................................................................................................................................................................KLLDDEFTKLKATPSSVPQNDHLMRQFREAVWNVHHAGEPMPGDDDEDCPLSGKPVTELADP---------VRSMDCRHVYEKSVILHYIVNNPNCPVCRGKLQNSKVICDAMLKFEIEEMRSLNKQSNRAEVIEDFTEDVDED........................................................................................................... 339
57 -14.500[OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger  ali follow..  20...................................................................................................................................................................................................................................................................................................................KLVAPSIEEVNSNPNELRALRGRYFGVSDDDKDAIKEAAPKCNNCSQRGHLKKDCPHIATDDHYSRHCPCGHY-HSRCPSIW-FHTIYCYNCGGKFTGSNLSVELKQEYYRHMNRNSDENEDYQFSESIYDEDPLPRPSHKRHSQNDHSHSGRNKRRASNFHPPPYQKSNVIQPTIRGETLSLNNNISKNSRYQNTKVNVSSISENMYGSRYNPSTYVDNNSISNSSNYRNYNSYQPYRS.... 337
58 -14.300[D] KOG2186 Cell growth-regulating nucleolar protein  ali follow..  5...........................................................................................................................................................................................................................................................................................................................................................QCDDCGENLKKPRLPRHMSMTATKFSCIDCGNMFHNQCITQW-----FCSLCNATMTCEQDYFAHVYGKKHQEKANEVADMDYSKQQSEHPAVDKNNLTQQPDLDIYVGLSNDYPWFCSLCDINATSEQTLLAHANGKKHRVKVERFDAEQQKRQSTQHSTVDKKDYSKQQIEVDINVGLSNCYPWFCSLCNVKATCQQNLLS. 241
59 -14.300[R] KOG2789 Putative Zn-finger protein  ali follow..  113.......................................................................................................................................................................................................................................................................................................................RGSSDHLLTRNRSNSTPGSISADYRTTAITTIANAMECPICFLYYPSNFNYTR------------CAQPICSECFVE-ISEPAKCPYCMTERFGVIYKPNPKLTPFSFNNNPDTLPSNIAPMGTLSKSSLPLHHIPWPPNQHIKFAHDDKNVVSTDFIHPDWQYKLERARRRALRRAANATLLNSHLLETGPANANANHNTDLSHDPTSHGGPRRTLSSRRQHYLANVEQLMLAEAIR.. 362
60 -14.200[O] KOG1815 Predicted E3 ubiquitin ligase  ali follow..  15  67........................................................................................................................................................................................................................................................................DIRRHQMDNIERVSVVLSITEVEASI--------LLRHFHWSVGRVHDE------WFADEERVRKTVGILESHVVPPSDDSELTCGICFDSY-----------PPEKIASVSCGHPFCTTCWTGYISTT-RCP-CLAAVGHD................................................................................................................................................. 194
61 -13.900[U] KOG2066 Vacuolar assembly/sorting protein VPS41  ali follow..  10  360...................AASRLPLICGECKEEWEWAVNQFEEVKLCTLLAEVLPDGTPTLDPECYQKVLIACLFNNVKQFRKLV--VLMDALAHLYLYERKYESALKILMSC----QIFNVIDKHQLDQITELMNINSERALRLLLDNADSVEPSFVMEKILQLAYLTKLMSRNEGTEFADKAVQLYAEYDQKKLLPFLRKNANYNVNARKLCSDKGYIEETIYLLAKSGNHYDAVKMMVREYRNMEKVIDYCKDQNDPDLWIHLLGVVALIIEASNCLDPLLIMDKL---------IPNLSEALDKLLVDYTNHAELQQCCYDSTLNDLNVLTQGLISAADIVSRCSLCAQIII--NSNQETTKKFSDIKVFKCGHIFHLACSTSEMIEEGLCIACSDQ..................................................................................................................................................... 801
62 -13.900[O] KOG0314 Predicted E3 ubiquitin ligase  ali follow..  155...................................................................................................................................................................................................................................................................................................................KSMLMATPNGSYSLPSGAVAVLKPNEDAFEKEMEGLTSTTKCPLCKEVMR------------DAALASKCLKSYCDKCIRDHIIAKSMCVCGATHVLADDLLPNKTLRDTINRILESGNSSAENAGSMCQVQDMESVRCPPPKALSPTTSAASGGEKKPAPSNNNETSTLKPSIEIAEITSAWASAEIVKVEKPVDASANIQGSSNGKEAAVSQLNTQPPKEEMPQQVASGEQGKRKKKKPR.. 395
63 -13.900[K] COG5641 GATA Zn-finger-containing transcription factor  ali follow..  104.................................................................................................................................................................................................................................................................................................................................KNQVKNNGQTMDANCNNNVSNDANVPVCKNCLTSTTP-----RRDEHGAML----CN-----ACL--FLKLHGK-PI-KTDVIKSRNRKSNTNHAHNLDNFRNQTLIAELKGDCNIESSGRKANRVTSEDKKKKSSQLLMGTSSTAKISKKPKTESKERSDSHLSATKLEVLMSGDCSRPNLKPKLPKQDTAIYQEKLLTFPSYTDVKEYSNSAHQSAFIKERSQFNAA. 321
64 -13.800[R] KOG0490 Transcription factor, contains HOX domain  ali follow..  31...........................................................................................................................................................................................................................................................................................................................................................QCCECKTNL----SEKCFSREGKGTKCAGCSKVFHLNCF--------TCMVCNKQLSTGEELYVIDENK-KDDYLSSSSLKEGSLNSVSSCTDRSLSPDLQDALQDDPKETDNSTSSDKETANNENEEQNSGTKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARR. 248
65 -13.800[DR] KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins  ali follow..  21  537..........................................................................................................................................................................................................................................................................................................................KNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDK-------------EVSVVFIPCGHL--QECAPS-----RKCPICRGIIKG.................................................................................................................................................. 611
66 -13.800[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  11  785...........................................................................................................................................................................................................................................................................................................YEQISRRTDDIKLELDDEREKKKLEEELMELNKELEELGSESVEAAIVRCGVCFDRPK-----------EVVIVK--CYHLFCQQCIQRSLERHRKCPGCGTAFGQND................................................................................................................................................ 893
67 -13.700[S] KOG3726 Uncharacterized conserved protein  ali follow..  10  348.............LNTSWERVSTEVRDYVYRQEARLEWALGLLHVLLSCTFLLVLHASFSYMDSYNHDIRFDNIYISTYFCQIDD---------------------------------TLLPLRKAEEKTVIFPCKPTIQASEMSNVVRLETLPILLLLVVLCGLDWALYSIFDTIRHHSFLQYSF----LEVKVGGDSMLARLLRKTIGALNTSSETVMESNNMPCLPQ-----------------------------VGLDARAYWRAAVPIGLLVCLCLLQAFGYRLRRVIAAFYFPKREKKRILFLYNDL--LKKRAAFTKLRRAAILRRERQQKAPRHPLCRRCVVC---------QAPETPESYVCRTLDCEAVYCWSC---WDDMRQRCPVCTPREELSSSAFSDSNDDTAYAG.................................................................................................................................. 706
68 -13.600[O] KOG0006 E3 ubiquitin-protein ligase (Parkin protein)  ali follow..  11  181...............................................................................................................................................................................................................................................................................................................................FFKCGAHPTSDKETPVALHLIATNSRNITCITCTDVR-----------SPVLVFQCNSRHVICLDCFHLYCVTR-PCVAPNSLIKELH................................................................................................................................................ 274
69 -13.500[O] KOG4159 Predicted E3 ubiquitin ligase  ali follow..  15  6..................................................................................................................................................................................................................................................................................................................................................................................EPVTTPCGHSFCKNCLERCLDHAPYCPLCKESLKEYLADRRYCVTQLLEELIVKYLPDELSERKKIYDEETAE............................................................................................................ 78
70 -13.400[B] COG5034 Chromatin remodeling protein, contains PhD zinc finger  ali follow..  214.......................................................................................................................................................................................................................................................................................................................RPVRRSESRLKQTNGEPLVKHDTLDSSDISREGEQLYC-YCQQ---------------SYGQMIGCDN-FHLPCVGIWY-----CKECEELAKSSESRQ............................................................................................................................................. 305
71 -13.300[R] KOG3612 PHD Zn-finger protein  ali follow..  12  790..........................................................................................................................................................................................................................................................................................................MKHNLELTMAEMRQSLEQERD--RLIAEVKKQLELEKQQAVDETKKKQ--CANCKKE-----------------AIFYC-------C---W--NTSYCDYCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQGSDH-------------------SRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESLDTF 993
72 -13.300[R] COG5236 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  17  27.......................................................................................................................................................................................................................................................................................................................PHNDRKNFRRKQKKNNLSAEPNLTTSSADDTDEENELCVICARKL-------------TYVSLTPCHHKTCHICGFR-LYNKKSCLICRTEN.................................................................................................................................................... 107
73 -13.200[O] KOG1039 Predicted E3 ubiquitin ligase  ali follow..  18  204..........................................................................................................................................................................................................................................................................................................................FDPEQRKAHEKICMLTFEHEMEKAFAFQASQDKVCSICMEVILEKASASERR------ILSNCNHTYCLSCIRQWRCAKQSCPECRVIVIPSVYWVEDQNKKNELIEAFKQGMGK.......................................................................................................................... 324
74 -13.100[K] KOG2494 C3H1-type Zn-finger protein  ali follow..  154..................................................................................................................................................................................................................................................................................................................................LIPGNPPLAMPGAVGPKLMRSDKLEVCR-C--------------TRGEN----DCRYA-HPTC-MDYI--KGRCEKCKYFHPPAHLQARLKAAHHQMNHSAASAMALQPGTLQLIPKRSALEKPNGATPVFNPTVFHCQQALTNLQLPQPAFIPAGPILCMAPASNIVPMMHGATPTTVSAATTPATSVPFAAPTTGNQLK............................ 353
75 -13.100[U] KOG2034 Vacuolar sorting protein PEP3/VPS18  ali follow..  11  416........AASFYAKINYVISFEEVTLKFISINEPEALRTFLDDKCQITMISTWATELYL-VIQEFRAFMSDCKDELDEATTVKIL----VEELVYFANLKEQYEIVVLHYIQQGEAKKALEVLQKSSIKYLEFCVHRLHNEDPGIHSLLLSLYA----------DGALLRFLQCKFGKGRENGPEFFYDPKYALRLCLKRTRACVHIYSMMSMHEEAVALALQIDPELAMAEADKVEDDEDLRKKLWLMVAKHVVKQEKGAKRENIRKAIAFLKETDGLLKIEDILPFFPDFALIDDFKEAICSSLEDYNKQIEQLKEEMNDATRGADNIRNSALTQRYAVIDRDEECGVCKRKILMMSQGYSSAGPLAPFYVFPCGHSFHAQCLIT-LQKQSECPFC-LPFIKPEDSQYSTSWDLRSETNLANQRTIS......................................................................................................................... 991

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Friedberg I, Harder T, Kolodny R, Sitbon E, Li Z, Godzik A. Using an alignment of fragment strings for comparing protein structures. Bioinformatics. 2007 Jan 15;23(2):e219-24.