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Query: [C] COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC, from COG0312

Results of FFAS03 search in COG0312
Master-slave alignment does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MFKLFTARQHDKIWDFDGGIHPPEMKLQSSTVPMRIAPLPDQLIIPLQQHLGPEGELRVRAGEQVLKGQPLTVGRGRTVPVHAPTSGMITAIAPHTTAHPSGLAELCVHITPDGEDRWREQQPWADYRQRDKMALLDRIHQAGIAGLGGAGFPTASKLQGGLNGIITLIINAAECEPYITADDRLMQEHADEVITGIHILRHLLQPQQVLIGIEDNKPEAIAALQRALRGQDDIHLRVVPTKYPSGGAKQLTKILTGKEVPFGKHSSSIGVLMQNVGTVVAIKRAVIDDEPLIERVVTLTGDALSSPGNFWARIGTPVLYLLKLAGFKPQNPPMVIMGGPLMGFTLPSLDVPIVKISNCILAPAETEMGLSEPEQSCIRCGLCVDACPAGLLPQQLYWFSRGEEHEKARNHNLFDCIECGACAYVCPSNIPLVQYYRQEKAEIRALDQESARAAEAKARFEAKQARLAREKLARELRHKQAAVKLTDADQQTVDAAVSRLTRQSDGSESVINIPAGQMPDNSAVIAAREARKAQARARQAEKQQARSTEETTDVVDPRQAAVAAAIARVKAKKAVQAQHVTTDVAEAGSEAMAEDPRKAAVAAAIARVKAKKAAQAINPDLast
1 -154.000[C] COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC  ali  100  1MFKLFTARQHDKIWDFDGGIHPPEMKLQSSTVPMRIAPLPDQLIIPLQQHLGPEGELRVRAGEQVLKGQPLTVGRGRTVPVHAPTSGMITAIAPHTTAHPSGLAELCVHITPDGEDRWREQQPWADYRQRDKMALLDRIHQAGIAGLGGAGFPTASKLQGGLNGIITLIINAAECEPYITADDRLMQEHADEVITGIHILRHLLQPQQVLIGIEDNKPEAIAALQRALRGQDDIHLRVVPTKYPSGGAKQLTKILTGKEVPFGKHSSSIGVLMQNVGTVVAIKRAVIDDEPLIERVVTLTGDALSSPGNFWARIGTPVLYLLKLAGFKPQNPPMVIMGGPLMGFTLPSLDVPIVKISNCILAPAETEMGLSEPEQSCIRCGLCVDACPAGLLPQQLYWFSRGEEHEKARNHNLFDCIECGACAYVCPSNIPLVQYYRQEKAEIRALDQESARAAEAKARFEAKQARLAREKLARELRHKQAAVKLTDADQQTVDAAVSRLTRQSDGSESVINIPAGQMPDNSAVIAAREARKAQARARQAEKQQARSTEETTDVVDPRQAAVAAAIARVKAKKAVQAQHVTTDVAEAGSEAMAEDPRKAAVAAAIARVKAKKAAQAINPD 620
2 -68.200[C] COG1726 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA  ali follow..  16  1............MITIKKGLNLPISG--SPEQVIRDGNAITEVALLGEEYVGMRPSMKVREGDVVKKGQVLFEDKKNGVVFTAPASGTVTAIHRGAKRV-----LQSVVIKIEGNEQITFEKTTEQLNQLTSEQVRQNLQASGLWTALRTRPFSKVP--AVDATPVSIFVNAMDTNPLCADPQVIVQQSAQAFEAGLTVLSRLHEG-KVYLCKAANASIPSPSIA-------NLDVKEFAGPHPAGLSGTHIHFIDP-------VSATKFVWYINYQDVIAVGKLFTTGELDVSRVVSLAGPQVKNPRLVRTVLGANLSQLTA--NEVKDGENRVISGSVLSGAKAAGPVDYLGRYALQVSVLEEGTTALNGGERAMVPIGAYERVMPLDIIPTLLLRDLAAGDTDSAQALGCLELDELALCTFVCPGKNEYGPLLRQALDKIEKE.............................................................................................................................................................................. 445
3 -46.900[C] COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit  ali follow..  19  2...................................................................................TINSGTTKEIIRTPEMHPLTWRLRDDKQPVWLDEYRSKNGYAGLKGMAPTDVVNVVKDAGLKGRGGAGFSTGLKWSDDSMNIRYLLCNADEMEPGTYKDRLLMEQLPHLLVEGMLISAFALKAYRGYIFLRGEYIEAAVHLRRAIAEATELIVHTGAGRYICGEETALINSLEGRRANPRSKPWGKPTCVNNVETLCNVPAIIEHGVEWYQKLMGFSGR-VKNPGLWELPFGITAREILEDYAGGMRKFKAWQPGGAGTDFLTADLDLPMRLGTALAMAVDHEIGMVSLSRESCGWCTPCRDGLPWSVKILRALERGEGQPGDIETLEQLCRFLGPGFCAHAPGAVEPLQSAIKYFRDEFEAGIAVKAYESGMTSGNTRAIAGIQPNLLKAR................................................................................................................................................. 460
4 -46.600[C] KOG2658 NADH:ubiquinone oxidoreductase, NDUFV1/51kDa subunit  ali follow..  14  2......................APVRGILGLQRAVSIWKESNRLTP------ALRSFSTQ--AASTSTTPQPP---------PPPPPPEKTHFGGLKDEDRIFTNLYGLHDPF-LKGAMKRGDWHRTKDKGTDWIVNEMKKSGLRGRGGAGFPSGLKWSVSDGRPSYLVVNADESEPGTCKDREIMRHDPHKLLEGCLIAGVGMRASAAYIYIRGEYVNERLNLEKARREAYEVYIHFGAGAYICGEETALLESLEGKQGKPRLKPYGCPTTVTNVETVAVSPTILRRGPEWFSSFGRKNNAGVNKPCTVEEEMSIPLKELIERHCGGVDNLLAIIPGGSSVPLIPKNIDVLMGLGTAAVIVMDKSTDVVDAKHESCGQCTPCREGTGWLWMIMERMKVGNAKLEEIDMLQEVTKQIE-TICALGDAAAWPVQGLIRHFRPELERRIRERAERELLQA.................................................................................................................................................................. 484
5 -29.300[C] COG1152 CO dehydrogenase/acetyl-CoA synthase alpha subunit  ali follow..  10  94...................................................GIDAATQQART-ACLIGTAAHAGHARHL-VDHLIERLGEDYKIDLGSNVDIEAPITRTVMGKRPATLGDLREVMDYAE---EQMSHLLSACHT---GQEGDSKDFESK----AFHAGLMDDLTREVALAQIVALDLPKGDEDAPLVELGFGTIDTEKPVVLCIGHNVLPGADIVDYLDEEDQVEVCGIVTRYNEAA-KVVGPLSKQLRFIRSGVA-DVIVVDEQCVRTDVLEEALKNRSAVIATTDKMCLGLPDMTDEDPDKIVNDLIN--------GNIEGALILDPEKVGEVAVKTAMKLAPIRKSLKKLPDID-EIIELASECTDCGWCQRVCPNSLPVMDAVKKAADGDLSKLEEMAIEECYTCGRCEQECERNIPIVSMVTKAGERRVKDEKYRIRAGRGPAQDVEIRRVGAPIVLGDIPGVVAFVGCSNYPEGGKDVALMAKEFLERTGCGAMSIGEYRDEDGQTLYEKYGGQFDAKGLVNMGSCVSNAHVSGAAIKIANIFAQKPLEGNFEEIADYILNRVGACGVAWGAYSQKAAAIATGVNRWGI............... 644
6 -17.900[C] COG1150 Heterodisulfide reductase, subunit C  ali follow..  15  39......................................................................................................................................................................................................................................................................................................................................................................................QACYQCGTCTGSCPSSYRTRLIMRKLQLGLVDEVKSDELWMCTTCYTCYERCPRGVKIVDAVKAARNLAAKKGYMAKAHRMVAMFVIKT............................................................................................................................................................. 132
7 -16.500[C] COG1146 Ferredoxin  ali follow..  13  30........................................................................................................................................................................................................................................................................................................................................................................VDRKEIEWYPTIDYDKCVTCGICFVTCGRRVFDFD------KKEGKVIVARPYNCMVACQTCMNLCPTGAISFPDASYIKKLVAQNKIVKKAFEIIKPLLAEDHLSPKETETKPE................................................................................................................................................. 138
8 -16.500[C] KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit  ali follow..  19  1...................................................................................................................................................................................................................................................................................MSLTMRIFTASRNGQRLFGSH-LLAAQRAEPKDIVEVPKGYVYVNNKELSMEFADITDRAASGELLRGFAVPFEKGPLSPRFRGEHALRRYP----SGEERCIACKLCEAICPAQAITIEAEERADGSRRTTRYDIDMTKCIYCGFCQEACPVD............................................................................................................................................................................................... 170
9 -16.000[C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit  ali follow..  28  50.....................................................................................................................................................................................................................................................................................................................................................................................ESKCVKCYICWKFCPEPAIYIK---------EDGFVAIDYDYCKGCGICANECPTK--AITMVREEK.................................................................................................................................................................................... 105
10 -15.800[C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)  ali follow..  18  1.......................................................................................................................................................................................................................................................................................................MIKEIINVVHGTFTQLRSLVMIFGHAFR---------KRDTLQYP-------EEPVYLPPRYRGRIVLTRDP----DGEERCVACNLCAVACPVGCISLQKAETEDGRWYPEFFRINFSRCIFCGLCEEACPTTIQLTPDFEMGEFKRQDLVYEKHD........................................................................................................................................................................ 138
11 -12.500[C] COG1145 Ferredoxin  ali follow..  12  12....................................................................KLREKLNKAPIGLPKTVSGVEKELLSVLFDEEEAKIAVHMPFIRFTAEQLAERTGKSL----YVEKILNEMAKKGTV----DGQTYYRLFPVIVGFAETPFWPGPGKDPRQEKLARLWSQYRKEGFDREHPIMRALPERDTI---EKSEILPYEDAVKLVKERDYIAV--------------------------GYCPCRVMARLVGEGCRHSIENCIHMGSVGKYMVEHGLGRRISADEAIEILRQSNREGLVHLTERSKHVATICNCCSDCCVFFKAVHEAKHPN------TIAHSSYLATVDTSRCIACGICMLRCPMKAI--------KAKINREPASVDAEKCLGCGVCVPTCPME............................................................................................................................................................................................... 333
12 -12.400[C] COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain  ali follow..  13  38..............................................................................................................RQKMVEELGHWEEWREHAKEIRNHVIENLDAEKVIQNGGHVY---AATAEDATNYIKNVAKQKNAKKIVKSKSMVTEEGMNHVLEAEGIKVVETDLGEYILQVAEDKPSHIVVPAIHKDRHQIRKVLAEKLGYTGSDTPEEMTLFIRETIRNDFLEADIGVSGCNFAVAETGSVCLVTNEGNLRLATSL-------PKTHIAVMGMELAPTFKEVDVLITLLARSAVGGPRLAGETDGPEEFHLVIVDN----SKMLGSEFREVLRCIRCGACLNTCPAYRQPIGSVISPILGGYEEFKDL-PSACSLCTACNQVCPVKIPLANLLLKHRRHIAESGMNPLAER...................................................................................................................................................................... 400
13 -12.300[C] COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB  ali follow..  15  1...........................................................................................................................................................................................................................................................MNAIWIAVAAVXLLGLAFGAILGYASRRFAV-----EDDPVVEKIDEILPQS-----------QCGYPGCRPYAEAISCNGEKINRCAPGGEAVMLKLNVEPQPLDGEAQELTPARMVAVIDENNCIGCTKCIQACPVDAI---------VGATRAMHTVMSDLCTGCNLCVDPCPTH............................................................................................................................................................................................... 160
14 -12.200[C] COG0348 Polyferredoxin  ali follow..  13  1......................................................................................................................................MANSPKYAGKEAREKLGWWYANRFLFWRRLTQLSILAMFLSGPYFGVWILKGNYSSSLLLDLIPMTDPLIMAESLATGFMPTMTALLGALIVVV-----LYAILGSRVFPLNIVTDASAWLRRK---EIRQSAKLPRSLRYAILVMILLGSALSGLLLWEWLNPVAALGRALIYGFGATVWLVLAVFLFDLFIVEHGWCGHLC--PIGAAY-------------GVIGAKGLFRIKVEHRQQCDNCMDCYNVCPEPQVLRDPLHAKKSES----PLVLSKDCISCGRCIDVCPEKVFIFTTRFNHSVNHSGE.............................................................................................................................................................................. 291
15 -11.600[C] COG1141 Ferredoxin  ali follow..  9  50....................................................................................................................................................................................................................................................................................................................................................................................DEITCIGCKHCAHVARNTFY------IEPDYGRSRVIRQDGDAEEVIQEAIDTCPVD--CIHWVDYTELKNLEEDRKFQVIPVVGYPVDHAVATTEKRRRKQKSKNKKSR.......................................................................................................................................... 151
16 -10.200[C] COG2440 Ferredoxin-like protein  ali follow..  14  22...........................................................................................................................................................................................................................................................................................................................................................................DPGRPHIKVRPHERPSANALTHICPAKCY---------ELNDKGQVETTSDGCMECGTCRVLCEASGEI............................................................................................................................................................................................ 83
17 -9.870[C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit  ali follow..  14  9..................................................FGSDGTVGANKAAIKIIGDNTDLYAQGYFSYDSKKSGGLTVSHLRFGENR---------IRSAYLIQQADFVSCSTSAYLRSYDLLKGLKPGGTFLLNTI-LPAAMREYIAKNNIQFYTLNAMRIAGEAGLGRRI------------TVMQTAFFRVTDILPFE----KALADLKASAIA-----------TYGKKDMA---------------------VAEKNILAMDQTVANLHK-VEVPESWANPVLTAEASTATEKPAYVKNILEPVNRLEGDNLTVGDLISNGMVSGAY-----------PPGTAAYEKRGIALEVPEENCTMCNECAFVCPHAAIRPILTNEEEMESAPERIQVSPMDCTGCNLCAETCPAKDKALV.......................................................................................................................................................................................... 350
18 -9.860[R] COG1453 Predicted oxidoreductases of the aldo/keto reductase family  ali follow..  12  1.................................................................................................................................MLYRKMPKNGDELSILGFGCMRLPVKEDGSVDEERATRQVRYAID---YVDTAWPYHMGESEPFLGRA-----LADGYREKVKLATKLPSWMVKSREDMDKFLNAQLEKLKTDH----DYYLIHNLSGEKAKSDGRIVNAGFSFHGLANDFKLKYAASKGLGVMIMEPLRGGNLARTVPLAIENIERTPVEWALRWVWNHPEVTVVLSGMNEEVHIKENLKIPNSLTEAELQLVSKEQKYRQIMKVGCTGCQYCMP-CPSGVIPECFSIYNHLSTFGNAKPGMASQCVQCGQCLEKCPQHIDIPTILESVAEELEGSDLEERIA....................................................................................................................................................................... 390
19 -9.560[C] COG1142 Fe-S-cluster-containing hydrogenase components 2  ali follow..  15  48.....................................................................................................................................................................................................................................................................................................................................................................................PQLCHHCAPCAVVCPVNAITRV----------DGAVQLNESLCVSCKLCGIACPFGAIEFSGSRPLDIPANANTPKAPPAPPAPARISTLLDWVPGIRAIAVKCDLCSFDEQGPA---------------CVRMCPTKALHLVDNTDIARVSKRKRELTFNTDFGDLTL.............................................................................. 193
20 -9.520[C] KOG3049 Succinate dehydrogenase, Fe-S protein subunit  ali follow..  13  50..........................................................................................................................................................................DKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDST---LTFRRSCREGI-----------------------CGSCAMNI----------------------NGGNTLACTRRIDTNLNKVSKIYPLPHMYV-------------IKDLVPDLSNFYAQYKSI------EPYLKKKDESQEGKQQ---YLQSIEEREKLDGLYECILCACCSTSCPS-LGPAVLMQATEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKA......................................................................................................................................................................... 278
21 -9.340[C] COG0437 Fe-S-cluster-containing hydrogenase components 1  ali follow..  17  83...............................................................................................................................................................................................................................................................................................................................................................AMHKREDGFVVVDEDV---------CIGCRYCHMACPYGAPQYN------------AEKGHMTKCDGC-ICVESCPLRALEFGPIEELRQKHGTLAAVAPLPRAHFTK................................................................................................................................................................. 178
22 -9.180[C] COG1600 Uncharacterized Fe-S protein  ali follow..  20  8...............................................................................................................................KPLDLNQLAQNIKQWGLLGFQQVGI-TDTDLRASEPALQAWLDKQYHGEMAWMARHGMMRARPHELLPGT----------LRVISVRMNYLPANAAFASTLKDPTLGYV----SRYALGRD---------HKLLRSRLKKLGEQIQQYCGSL---FRPFVDSAPILERPLAEKAG-----------TGKHSLILNREAGSF------------FLGELLIDLPLPVDQ----------------PVEEGCGKCVACMTICPTGAIVEP--------------TVDARRCISCDDCQLICP................................................................................................................................................................................................. 259
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.