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Query: [E] COG3483 Tryptophan 2,3-dioxygenase (vermilion), from COG0516

Results of FFAS03 search in COG0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MCPCPHSQAQGETDGEAEWHNAALDFTHAMSYGDYLKLDKVLDAQFPLSPDHNEMLFIIQHQTSELWMKLMLHELRAAREHVKSGKLGPALKMLARVSRIFDQLVHAWAVLATMTPTEYNTIRPYLGQSSGFQSYQYREIEFILGNKNATLLKPHAHRAELLAALEQALHTPSLYDEAIRLMAAQGLPVSQERLARDAAAGTCYEASVEAAWRQVYQAPERYWDLYQLAEKLIDLEDSFRQWRFRHVTTVERIIGFKPGTGGTEGVGYLRSMLDTILFPELWRLRSNLLast
1 -121.000[E] COG3483 Tryptophan 2,3-dioxygenase (vermilion)  ali  100  1MCPCPHSQAQGETDGEAEWHNAALDFTHAMSYGDYLKLDKVLDAQFPLSPDHNEMLFIIQHQTSELWMKLMLHELRAAREHVKSGKLGPALKMLARVSRIFDQLVHAWAVLATMTPTEYNTIRPYLGQSSGFQSYQYREIEFILGNKNATLLKPHAHRAELLAALEQALHTPSLYDEAIRLMAAQGLPVSQERLARDAAAGTCYEASVEAAWRQVYQAPERYWDLYQLAEKLIDLEDSFRQWRFRHVTTVERIIGFKPGTGGTEGVGYLRSMLDTILFPELWRLRSNL 288
2 -5.460[C] COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit  ali follow..  17  61....................................................DALLYIKNNIDPTLTLRRSCREGICGSCAMNIDGTN-TLACTKGMEEIKGTV--------KVYPLPHMPVKDLVPDLSNFYA-QHRSIEPWLKTVSPTPAKEWKQSHEDRLKLD------GLYECILCACCSTSCP----------GDRYLGPAVLLQAYRWLIDSRDEA-----TGERLDNLEDPFRLYRCHTIMNCAQAC--PKGLNPAKAIAEIKKMM............... 254
3 -5.350[S] COG2445 Uncharacterized conserved protein  ali follow..  14  6..............................................................................................DLIERRLAEIKGAINELRDIGDLGLEEFLTNSHIRYAAKYLLIMAIGGAFS---------------CNHIVVRKGDIPSSYSDCFLKLSRLG------IISGDLAERLAQMAKFRNMLVHVYWRIDDEKVFEILREDIVDLEEFIRA............................................... 132
4 -5.290[A] KOG1914 mRNA cleavage and polyadenylation factor I complex, subunit RNA14  ali follow..  11  2..........SGLSMRNPERRIETNPFDVDAWNLLLREHQSRPIDQERD----ESLVKQFPNSGRYWKAYIEHE-------LRSKNFENVEKLFSRCLVSVLNI-DLW--------KCYIHYFETKGQRDQYREEMAKAYDFALEKQAYSIFTEYIAFLKKVPAVGQYAENQRI--TAVRKIYQKALATPMHNLELIWNDTYEKAINITLAEKLIAERGKEYQNARRVEKDLQQMTRGLNRWKIAWEKTNPLQTEEYGQHARRVVYTYEQSLLCLGYYPDIW...... 282
5 -5.210[L] COG3316 Transposase and inactivated derivatives  ali follow..  16  3..........................................................VDHTTIYRWVQKYAPELD---------------KQTRWYRQVPDWQASSWRVDETYI------------RVGGTWCYLYRAIT---GQTLEFYLSPKRNVAAAKRFLAKTLRSNTTAGSPRVINTDKAPALAKAISELKAEGICPQTVEHRQV---------------KYLNNVIEGDHGRLKRILGPKGAFKNRISAYRTLKGMEAMHSLRK................. 172
6 -5.170[K] COG4941 Predicted RNA polymerase sigma factor containing a TPR repeat domain  ali follow..  13  103............................................GAHYRDDILRLLFVCSNPALPATQQIAL----RIVSGLSVRQIARAFAMEQRITRAKARVAAA-ERLAAVATMIYLVFNEGYSAMNGPEGVSADLCDEAI-RLSRLLLRLFPAEPEMMGLTALLLQDRRLWS---RPMITEALAMIDKAMRHRRPGPYQIQAAIAALHARAERPEQTDW------EEIDLLYQALERLQPSPVVTLNRAVAVSKREGPEAALAMVEPLGRLSGYFYYHGLRGGL 373
7 -5.090[V] COG3023 Negative regulator of beta-lactamase expression  ali follow..  11  20................................PDYKEAELDPSPNFGPRRDGKQPVFLILHYTGKEAMDVLKSPEMEVSAHYVVHEDGRVVQMVSEKARAWHAGKSFWKGETDINSASIGIEIVNPGVLENYPPFHDAQIE-------------------------------AVIRLCQDICKRHEIRPENVLAHSDIAPARKTDPGQSFPWKRLHDAGIGHYVEPTPICGGRFLARGEQGQPVEALQSMLALYGYEIAITGDEATEIVIKAFQRHFRPQNVD..... 245
8 -5.070[C] KOG3049 Succinate dehydrogenase, Fe-S protein subunit  ali follow..  18  74....................................................DALIKIKNEVDSTLTFRRSCREGICGSCAMNIN----GGNTLACTRRIDTNLNKV----SKIYPLPHMYIKDLVPDLSNFYA-QYKSIEPYLKKKDES-----EGKQQYLQSIEEREKLDGLYECILCACCSTSCP----------GDKYLGPAVLMQAYRWMIDSRDDF-----TEERLAKLQDPFSLYRCHTIMNCTRTC--PKGLNPGKAIAEIKKMM............... 270
9 -5.030[HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases  ali follow..  11  43..........................................KLAETWTFKPGQFVQLTIPGVGEVPISI-------CSSPMRRGFFELCIRRAGRVT----------TVVHRLKPGDIVLVRGPYGNGFPVDEWEGMDLLLIAAGLGAAPLR---------SVFLYAMDNRWKYGNITFIN---TARYGKDLLFYKELEAIKDLAEAENVKIIQSVTRDPNWP------LHGRPQQFIVEANTNPKNTAVAICG................................. 221
10 -4.970[I] COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)  ali follow..  11  111..........................DATVKGGTYLTVKKHLRAQEIATENRLPCIYLVDSGGANLPNQDEVFPDRDHFGRIFYNQANMSAAGIAQIAVVMGSCTAGGAYVPAMSDQSVIVKNQGTIFLGG-------LVKAATGE---LVSAEDLGGADVHSRQSGVTDHYANDDRHALSLTRRIVS-RRKQVELDIREPVEPLYPADELYGIVPSDTRKPFEVREIIARLVDFDEFKALYGTTLVCGFAHIHGYPVGIIANNGILFSESALKGAHFIELCCQRG.. 369

FFAS is supported by the NIH grant R01-GM087218-01
8 2 9 3 1   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Friedberg I, Jaroszewski L, Ye Y, Godzik A. The interplay of fold recognition and experimental structure determination in structural genomics. Curr Opin Struct Biol. 2004 Jun;14(3):307-12.