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Query: [S] COG3398 Uncharacterized protein conserved in archaea, from COG0516

Results of FFAS03 search in COG0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDLRAIYLIFAGTKFEKKFTICLLLFLLTTTAGAKEYIVSPCTSDQAGVSVNGEEVVLLEDTIEPYWHFLLWLALMNVLSVVDVLILPAKLIFAILGFRITERADVFENSNRARIYEYIKTRPGAYLSEIIEKAGIDRGAARYHIKILKAHHKIEAYRESGKTRYFQNNSTYGEEEKKVVSALQNATNQRIISEIQNGKCNTNLALAREIGVSRATISWYVKNLKETGLIDETRSGRSIIYSINPSYEPLIEKYGLast
1 -91.600[S] COG3398 Uncharacterized protein conserved in archaea  ali  100  1MDLRAIYLIFAGTKFEKKFTICLLLFLLTTTAGAKEYIVSPCTSDQAGVSVNGEEVVLLEDTIEPYWHFLLWLALMNVLSVVDVLILPAKLIFAILGFRITERADVFENSNRARIYEYIKTRPGAYLSEIIEKAGIDRGAARYHIKILKAHHKIEAYRESGKTRYFQNNSTYGEEEKKVVSALQNATNQRIISEIQNGKCNTNLALAREIGVSRATISWYVKNLKETGLIDETRSGRSIIYSINPSYEPLIEKYG 255
2 -19.900[K] COG1777 Predicted transcriptional regulators  ali follow..  21  1...........................................................................................................................................................................MIDDIDNFIAAIENSTRREIIRMLTQFERSYALELSRSIGLSQQAILKQLEMLERANLVTSIGFVP.................. 66
3 -16.200[S] COG2512 Uncharacterized membrane-associated protein/domain  ali follow..  22  248.........................................................................................................................................................................................PELCEVLDIIRGHKGITQKDLRSKLDYSEVKVSLMLSELEKRGLIRKLRNGRENILVLVDE......... 309
4 -16.000[K] COG4190 Predicted transcriptional regulator  ali follow..  11  63...................................................................................................................................................................................LMDTLTPRVLELIEAIRQEEPASINETARVVDRDVKNVHEELSRLAHLGIIFFEEDGQRKRPVVWFDELVI..... 133
5 -16.000[K] COG2345 Predicted transcriptional regulator  ali follow..  14  14...........................................................................................................DGDTRRKILLILLERAPVIASDIAEQLQLSTVGVRRHLDNLVEENLAEAANPGRPAKTYRLTDEYDSLAAAALATLREVGGDDAVRQFARKRIETIVEGITPADVTDQSIEDTAKSLVEA----FSRHGYAATVDATRNGLQLCQHH. 174
6 -15.900[K] COG1497 Predicted transcriptional regulator  ali follow..  21  3..................................................................................................................................................................................ALRKKGELTRFQILSEIAMQPYVRQKDIADKLGVTVQAVSENIKSLIAEGLV--ESGSGRSHYKITRRGAEKIKEA. 77
7 -15.100[K] COG3355 Predicted transcriptional regulator  ali follow..  21  26........................................................................................................................................................................................SKSDVEVLHILLQNGKMTTDDLSQKLNVTKASISKALNNLLDKGLIQREKA.................... 76
8 -14.500[K] COG3432 Predicted transcriptional regulator  ali follow..  14  32.......................................................................................................................................................................................RKRGTMEIMFDILREPKCGITRVIYGAGINYVVAQKYLDQLVKVGALNIKTENDRKIYEITEKGKLLRTHI. 104
9 -14.000[K] COG4189 Predicted transcriptional regulator  ali follow..  18........................................................................................................KAAASLIRVQILKLLHEANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRKARKGSQKICFATCDELIVSFRKPETPAASNYIAVAMPLGLYTQSSVTAPCGICSPE....................................... 129
10 -13.700[KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon  ali follow..  26  13.............................................................................................................................................................................................AKMGAIGKEITVTMRELSRELDVSPQTVLRWLEELKEQGYIHKRESRKGTLVELTEKGINLLEK.. 76
11 -13.200[K] COG0640 Predicted transcriptional regulators  ali follow..  14  1..............................................................................................................................MNEITMQTQADQPKVSSNLAILSEARLVDSIQMGREKIYRIAPEKFEDMVDWLDSILHSANYGLSPVNDLNYARTCYDHLAGEMGVY-------LEELLKRKWIILD-DPEKPTYRLTTAGAEELTVRG 128
12 -13.000[K] COG5111 DNA-directed RNA polymerase III, subunit C34  ali follow..  15  9............................................................................................................PKNAKVIYEHCLKQISLSQQDLVEAISISVNDLSSALNILLSRRLLDPLRQGNVLVYRAVRLDEAKTVSTM-----EGDEQIVYSFIKNSGGIWRKTLTLRTNLHVSVVDRCLKSLESKNLVKSIKSPTRKIYMLYD.......... 149
13 -13.000[K] COG3711 Transcriptional antiterminator  ali follow..  14  2............................................................................................................NGDNQQILREIVLNPTIHGKELESIFGLSRRQLGYRIQKINLQGNFIVSSEIMTLFKRDVSEQQMLNGNNVIFSIETRRYYLMLMLFSKENAMSLNHFSIDLQVSKNTVIHDINHVKE-SLKYSRKHG................... 149
14 -12.700[S] COG4861 Uncharacterized protein conserved in bacteria  ali follow..  11  60....................................................................................................TAALQAWDTAGAGSPLLVVGPRLHPSSAETLRARGLWYIDGAGNAYLRHQGGLLIDVRGRRSAVSAQPGTLGDGLHSDGPRNPFTPKRAQVVCVLLDAPQLPLRAIAASAGVSVGMAKETMDTLRTTGFFEHLGSRRRLV-----RTDELLDLWA 212
15 -12.500[K] KOG3233 RNA polymerase III, subunit C34  ali follow..  16  16............................................................................................................VEIENRIIELCHQFPGITDQVIQNEMHIEAQQRAVAINRLLSMGQLDLLRSNTGLLYRIKDSQNAGKMKGS-----DNQEKLVYQIIEDAGGIWSRDIRYKSNLPLTEINKILKNLESKKLIKAVKSSKKKVYMLYN.......... 154
16 -12.400[S] COG4344 Uncharacterized protein conserved in archaea  ali follow..  19  1...........................................................................................................................................................................MSEYEKEIDELINDYDMLRVLKHFTIAHVDYAKNITRYTEIPQMRVREYLKRLKDLGLLDYYTNTHHTYYQINKKAEAVLKE.. 99
17 -12.400[K] COG5631 Predicted transcription regulator, contains HTH domain (MarR family)  ali follow..  10  88..............................................................................................................................................................................................ILHSIHRDREKKLADICLALDIEDHIATYAIRKLEKAGLLTTGKAAKEKTVKITAKGAEACAHYA 154
18 -12.300[K] COG4738 Predicted transcriptional regulator  ali follow..  18  17..........................................................................................................................................................................KMGEVEYEMVELLRNRPVALTLACLSKGDEISSQRIEMVSGLRQPEVSIAMRYLRENEWVDMREEKKNKLYKLTVQMETIIDT.. 110
19 -12.100[S] KOG4608 Uncharacterized conserved protein  ali follow..  12  84.................................................................................................IQTGGKFEIQRRREIRAVCHVIKATRGITLGELCGKVKIAKEQIAEILADLSGAAQILAAGVDEKRWVMPEPRPWIAPEGCISLPVVRWMAESALVLIVSKLGIQLKDVITTYEVQPIAIREIVRKEKSAKKSPKI...................... 238
20 -11.600[K] COG4742 Predicted transcriptional regulator  ali follow..  13  3...............................................................................................................................................................................SELIDVVFRSQKRRDLLLLLGEEP-RTMEDIKVLLDVSPTAILPQIKRLTDSNLVIQKNGS----YELTDMGEQVFKKA. 76
21 -11.400[K] COG1846 Transcriptional regulators  ali follow..  18  41........................................................................................................................................................................................TPSEIHTIDAIGTDEGLLMKELAERLGVTKGAVSQLVDRLEAKALVRRTAVSRGIQVVLTDKGREAYRAH. 113
22 -11.400[T] KOG4603 TBP-1 interacting protein  ali follow..  1...................................................................................................MSKGRAEAAAGAAGILLRYLEQNRPYSSQDVFGNLGLGKAVVVKTLEQLAQQGKIKEKMYGKQKIYFADQDQFDMVSDADLQVLDGKIVA----------TAKVQSLQQSCRYMEAELKELSSALTTPEMQKEIQELKKECAGYRERLKNI..... 147
23 -11.400[K] COG1695 Predicted transcriptional regulators  ali follow..  14  3.........................................................................................................................................................................................RYAIKALVLLSKKP---SKEISTGVQVSHGTLMPMIRKLLQERYIDFETRGREKVYHLTERGSRFVES.. 73
24 -10.900[K] COG1510 Predicted transcriptional regulators  ali follow..  20  30........................................................................................................................................................................................PSTVGRVLGIIMNRKPMTLSELSEATGMSKTRMSQVVREMIDANIAEKEKGVRKDLYDVEQDYYQTFISL. 102
25 -10.400[R] COG1672 Predicted ATPase (AAA+ superfamily)  ali follow..  19  119...........................................................................SILQEYWDLKLSNGRIFLIICGSSISMMEKLLGYKSRRTGQINLKP-PGYSLEDFIKAYGILGG-SPAHLLEFDDSKTIKEN----LEYLRSDSLLYQDAFFVLREELEEPRNYFAIMEAVAAGKTSLGEIMNETGLSRATVAKYLSVLIELDFVKRERKSRRGRYYIKDNYFAFWFRY. 312
26 -10.400[L] COG3415 Transposase and inactivated derivatives  ali follow..  14  18.................................................................................................LDKRIKKLEKDTRVLQRLYFIRYLYRGMSVEEAAELVGITKATGYTWLKRWNTRGY---------------EGLIPEFGGGRPSKLTKDQKEELKEMLKERDSWTTKEVQELISYSSWQVR---RILKSFGM--KYAKPYQKDYRKPENAEDSLKKHG 161
27 -10.300[KG] COG1349 Transcriptional regulators of sugar metabolism  ali follow..  1.........................................................................................................MKPRQRQAAILEHLQKQGKCSVEELAQYFDTTGTTIRKDLVILENAGTVIRTYGGVVLNKEESDPPIDHKTLINTHK-KALIAAAAVKYIHDGD-----SIILDAGSTVLQMVPLLSRFSNITVMTNS...................... 122
28 -10.300[K] KOG2593 Transcription initiation factor IIE, alpha subunit  ali follow..  11  9....................................................................................................................................................................FYDNYTPKNNNQKKSAKNGSGGIAVLVLDALTRRQWVREEDLAKELKLNTKQLRTILRYFEEQQFIMRVHRKEKSYCCLDYSQIYDVIRY. 116
29 -10.200[R] COG2522 Predicted transcriptional regulator  ali follow..  11  10................................................................................................................................................................................EYAAKNIFPSIRASIAKILVEEYKMSKYSVAKMLGATPTAVSYYISGKRGEKFVDRIIRDEEIYSIVREAASLLVE... 85
30 -10.100[L] COG2801 Transposase and inactivated derivatives  ali follow..  11  6.............................................................................................................CEKIEIIRLVEQS-TLPVRRTLAQIGVPRATFYRWYDLYQTGGPEALEDRPARPSRVWNR-------------IPEDVRAAILEMALEHSELSPRELAVRFTVSEASVY---RLLKSHDLITSPAFIV.................. 122
31 -10.100[K] COG1654 Biotin operon repressor  ali follow..  24  3.......................................................................................................................................................................................DTTVPLTLISLLADGEFHSGEQLGERLGMSRAAINKHIQTLRDWGVDVFTVPGK---YSLPEPI........ 64
32 -10.000[DR] COG5124 Protein predicted to be involved in meiotic recombination  ali follow..  11  1....................................................................................................MVTVKMKSDQKKSILLEIIRGSKSFFLESLGSKKGIVVNTIKEILQQLVDDGLVTAEKVGTSNLYWSFASEGIQKKKLRCKELMEECERMSQDICRKREYIENEKMSKHYTEERNELENKLNALMKI............................ 131
33 -10.000[DR] KOG3433 Protein involved in meiotic recombination/predicted coiled-coil protein  ali follow..  11  1....................................................................................................MVTVKMKSDQKKSILLEIIRGSKSFFLESLGSKKGIVVNTIKEILQQLVDDGLVTAEKVGTSNLYWSFASEGIQKKKLRCKELMEECERMSQDICRKREYIENEKMSKHYTEERNELENKLNALMKI............................ 131
34 -9.950[R] COG3413 Predicted DNA binding protein  ali follow..  11  98..................................................................................................................VVPPLRVANGVEKWFVYTPDEISQRDIKRQLEMDNATHISRIRELTLKSFLKVIFNMDFLSDFIDTMEALTDLQVKTIKQAYVNGRCTLGDLAKINGISKNAMAKRLKS-VEKKIFEC....................... 220
35 -9.880[K] COG5625 Predicted transcription regulator containing HTH domain  ali follow..  18  19......................................................................................................................................................................................LKKNEIRIYRLLVEKRRGMRIREIQRELGISERSVRTHVLNLYRRGLLKRESGWLGYIYTPVSEILQKIKE.. 94
36 -9.760[K] COG3888 Predicted transcriptional regulator  ali follow..  21  2.........................................................................................................................................................................................SLRDVLLRELKRARGIDQFQIEEMMGFSKSTVSEALKDLEEKGIIKRRTIGG.................. 55
37 -9.610[S] COG4519 Uncharacterized protein conserved in bacteria  ali follow..  16  13..............................................................................................................................................................................................LALLVESLERPNVPKLIEKTGWPRRTIQDVIKAMPGIGIVQDGRRHNDGYYQLSD.......... 71
38 -9.610[T] COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases  ali follow..  15  77............................................................................................................EDGRRQILNYV---PG----DLVGLQGTVMGEMEHSVEALSPNNLFTDHPTLAFDLTWIAASEERMLDNHLLSIGRRTAIERAAYLIAF--PVTQQHVADTLGLSIVHTNKTLRKLVDRGLIRWIDK.................... 223
39 -9.590[C] COG1145 Ferredoxin  ali follow..  16  1................................................................................................................................................MHHSHHLEIYEKLREKLNKAPIGLPKTVSGVEKELLSVLFDEEEAKIAVHMPFIR-FTAEQLAERTGKSLEYVEKILNEMAKKGTVWKGEKDGQTYYRLFPVIVGFAE... 107
40 -9.520[S] COG3373 Uncharacterized protein conserved in archaea  ali follow..  11  8................................................................................................................................................................................NILRSLNRSELRRKVLFYLLSIYRSYLSEISRAVKSDPSNVKGCLESLIGLGLVIVEQSKNGKYFKINPEIVEEVR... 96
41 -9.440[K] COG1733 Predicted transcriptional regulators  ali follow..  15  13................................................................................................................................................................................SMAAEVLCTRWTMVLMRELVAGS-TRFNDLRRGVKMSPTLLSQRLKELELAGIVERKEEKGIFDYRLTEPVVEAMGFWG 100
42 -9.290[K] COG1522 Transcriptional regulators  ali follow..  22  7........................................................................................................................................................................................DKIDRKILEVLQSNGRLTNLEVAERVNLSPSPCLRRIRRLEESGVIRQ....................... 54
43 -9.230[S] COG3388 Uncharacterized protein conserved in archaea  ali follow..  16  18.........................................................................................................................................................................................KRHISVINVLLREQPIGIIKLSQETGIPEHKIRYSLRILEQENIISPSREGAIL................ 71
44 -9.100[K] COG3682 Predicted transcriptional regulator  ali follow..  16  4............................................................................................................TAAEAHVMEALWRRSPLSADELVAEVSWGEATVKTLINRLLKKKAIKSERAEGKHGYRPRSAYVQAESQGLLDRLFDGQLAPLISHFAQHRPLKPDEVAK............................................... 110
45 -9.040[S] COG3177 Uncharacterized conserved protein  ali follow..  227..................................................................................................................PTAVFCSDRNRYYEMLSQADKGTEEDCTYVLSGISRE--LQKVDKLTSQQFLNENILFPAIQYSQKRQFINEDEAKILRFAVEQREFKAGDLAKLFSMNANQRTYQIKKLVESGFISPLEENSRIYIYLIRGVIYALRENG 376

FFAS is supported by the NIH grant R01-GM087218-01
8 5 8 8 9   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Ye Y, Godzik A. Comparative analysis of protein domain organization. Genome Res. 2004 Mar;14(3):343-53.