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Query: [S] COG3398 Uncharacterized protein conserved in archaea, from COG0312

Results of FFAS03 search in COG0312
Master-slave alignment does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDLRAIYLIFAGTKFEKKFTICLLLFLLTTTAGAKEYIVSPCTSDQAGVSVNGEEVVLLEDTIEPYWHFLLWLALMNVLSVVDVLILPAKLIFAILGFRITERADVFENSNRARIYEYIKTRPGAYLSEIIEKAGIDRGAARYHIKILKAHHKIEAYRESGKTRYFQNNSTYGEEEKKVVSALQNATNQRIISEIQNGKCNTNLALAREIGVSRATISWYVKNLKETGLIDETRSGRSIIYSINPSYEPLIEKYGLast
1 -99.800[S] COG3398 Uncharacterized protein conserved in archaea  ali  100  1MDLRAIYLIFAGTKFEKKFTICLLLFLLTTTAGAKEYIVSPCTSDQAGVSVNGEEVVLLEDTIEPYWHFLLWLALMNVLSVVDVLILPAKLIFAILGFRITERADVFENSNRARIYEYIKTRPGAYLSEIIEKAGIDRGAARYHIKILKAHHKIEAYRESGKTRYFQNNSTYGEEEKKVVSALQNATNQRIISEIQNGKCNTNLALAREIGVSRATISWYVKNLKETGLIDETRSGRSIIYSINPSYEPLIEKYG 255
2 -25.900[K] COG1777 Predicted transcriptional regulators  ali follow..  18  1...........................................................................................................................................................................MIDDIDNFIAAIENSTRREIIRMLTQFERSYALELSRSIGLSQQAILKQLEMLERANLVTSIGFVPRKLYEPTGFSTLIVDYG. 89
3 -23.000[K] COG4190 Predicted transcriptional regulator  ali follow..  8  3.......................................................................................................................ESTPPLHPMEREQLRAESTLVVTVTPSSEFHDDITDSIAALEQGDAMDSTPTLSFTSYDDLMDTLTPRVLELIEAIRQEEPASINETARVVDRDVKNVHEELSRLAHLGIIFFEEDGQRKRPVVWFDELVINLPFD 138
4 -21.800[K] COG2345 Predicted transcriptional regulator  ali follow..  15  7....................................................................................................GNDAHTGDGDTRRKILLILLERAPVIASDIAEQLQLSTVGVRRHLDNLVEENLAEAANPRQNPYEPKMGHEYDSLAAAALATLREVGGDDAVRQFARKRIETIVEGITPADVTDQSIEDTAKSLVE............................. 150
5 -19.400[S] COG4860 Uncharacterized protein conserved in archaea  ali follow..  14  13..................................................................................................ELVSIFHAADSEVKRKLLLDLSTGW-ITLPVIEQKYGK---EGRRALLYLDKIKMIETQQNGPEKAYHTYYTNVQINIMGSLSELADEYEDKIKAMMKNGEGVFLGDVSDSLGISQTLIRGIVKRSSILEIRGYKIE.................... 162
6 -19.200[K] COG3432 Predicted transcriptional regulator  ali follow..  14  32.......................................................................................................................................................................................RKRGTMEIMFDILREPKCGITRVIYGAGINYVVAQKYLDQLVKVGALNIKTENDRKIYEITEKGKLLRTHI. 104
7 -18.400[K] COG0640 Predicted transcriptional regulators  ali follow..  14  1..............................................................................................................................MNEITMQTQADQPKVSSNLAILSEARLVDSIQMGREKIYRIAPEKFEDMVDWLDSILHSANYGLSPVNDLNYARTCYDHLAGEMGVY-------LEELLKRKWIILDDPEKPT-YRLTTAGAEELTVRG 128
8 -18.000[K] COG4738 Predicted transcriptional regulator  ali follow..  18  14.......................................................................................................................................................................NDFKMGEVEYEMVELLRNRPVALTLACLSKGDEISSQRIEMVSGLRQPEVSIAMRYLRENEWVDMREEKKNHLYKLTVQMETIIDT.. 110
9 -17.600[K] COG4189 Predicted transcriptional regulator  ali follow..  8  12..................................................................................................KEFDVLKAAASLIRVQILKLLHEANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRKARKGSQKICFATCDELIVSFRKPETPAASNYIAVAMPLGLYTQSSVTAPCGICSPE....................................... 129
10 -16.500[K] COG1497 Predicted transcriptional regulator  ali follow..  22  2.................................................................................................................................................................................KALRKKGELTRFQILSEIAMRPYVRQKDIADKLGVTVQAVSENIKSLIAEGLV--ESGSGRSHYKITRRGAEKIKEA. 77
11 -15.400[K] COG4742 Predicted transcriptional regulator  ali follow..  13  2..............................................................................................................................................................................QSELIDVVFRSQKRRDLLLLLGEEP-RTMEDIKVLLDVSPTAILPQIKRLTDSNLVIQKNGS----YELTDMGEQVFKKA. 76
12 -15.100[S] COG4344 Uncharacterized protein conserved in archaea  ali follow..  19  1...........................................................................................................................................................................MSEYEKEIDELINDYDMLRVLKHFTIAHVDYAKNITRYTEIPQMRVREYLKRLKDLGLLDYYTNTHHTYYQINKKAEAVLKE.. 99
13 -15.000[K] COG3355 Predicted transcriptional regulator  ali follow..  21  26........................................................................................................................................................................................SKSDVEVLHILLQNGKMTTDDLSQKLNVTKASISKALNNLLDKGLIQREKA.................... 76
14 -15.000[S] COG2512 Uncharacterized membrane-associated protein/domain  ali follow..  22  247........................................................................................................................................................................................SPELCEVLDIIRGHKGITQKDLRSKLDYSEVKVSLMLSELEKRGLIRKLRNGRENILVLVDE......... 309
15 -14.900[K] COG5111 DNA-directed RNA polymerase III, subunit C34  ali follow..  14  9............................................................................................................PKNAKVIYEHCLKQISLSQQDLVEAISISVNDLSSALNILLSRRLLDPLRQGNVLVYRAVRLDEAKTVSTM-----EGDEQIVYSFIKNNEGIWRKTLTLRTNLHVSVVDRCLKSLESKNLVKSIKNPTRKIYMLYD.......... 149
16 -14.700[K] COG3711 Transcriptional antiterminator  ali follow..  14  2............................................................................................................NGDNQQILREIVLNPTIHGKELESIFGLSRRQLGYRIQKINLQGNFIVSSEIMTLFKRDVSEQQMLNGNNVIFSIETRRYYLMLMLFSKENAMSLNHFSIDLQVSKNTVIHDINHVKE-SLKYSRKHG................... 149
17 -13.900[KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon  ali follow..  26  13.............................................................................................................................................................................................AKMGAIGKEITVTMRELSRELDVSPQTVLRWLEELKEQGYIHKRESRKGTLVELTEKGINLLEK.. 76
18 -13.700[K] COG1510 Predicted transcriptional regulators  ali follow..  20  30........................................................................................................................................................................................PSTVGRVLGIIMNRKPMTLSELSEATGMSKTRMSQVVREMIDANIAEKEKGVRKDLYDVEQDYYQTFIS.. 101
19 -13.700[S] COG3388 Uncharacterized protein conserved in archaea  ali follow..  15  13....................................................................................................................................................................................DMDTLKRHISVINVLLREQPIGIIKLSQETGIPEHKIRYSLRILEQENIISPSREGA.................. 69
20 -13.500[K] COG5631 Predicted transcription regulator, contains HTH domain (MarR family)  ali follow..  10  82........................................................................................................................................................................................SPIEILILHSIHRDREKKLADICLALDIEDHIATYAIRKLEKAGLLTTGKAAKEKTVKITAKGAEACAHY. 153
21 -13.500[K] KOG3233 RNA polymerase III, subunit C34  ali follow..  15  4................................................................................................VKVKVQPPDADPVEIENRIIELCHQFPGITDQVIQNEMHIEAQQRAVAINRLLSMGQLDLLRSNTGLLYRIKDSQNAGKMKGS-----DNQEKLVYQIIEDNKGIWSRDIRYKSNLPLTEINKILKNLESKKLIKAVAASKKKVYMLYN.......... 154
22 -13.400[K] COG1846 Transcriptional regulators  ali follow..  18  41........................................................................................................................................................................................TPSEIHTIDAIGTDEGLLMKELAERLGVTKGAVSQLVDRLEAKALVRRTAVSRGIQVVLTDKGREAYRA.. 112
23 -13.000[L] COG3415 Transposase and inactivated derivatives  ali follow..  18  18...............................................................................................LDKRIKKLEKDTRVLQRLYFIRYLYR--GMSVEEAAELVGITKATGYTWLKRWNTRGYEGLIPEFGGGR----------------SKLTKDQKEELKEMLKERDSWTTKEVQELISYSSWQVR---RILKSFGM--KYAKPYQKDYRKPENAEDSLKKHG 161
24 -12.600[S] COG4861 Uncharacterized protein conserved in bacteria  ali follow..  11  60....................................................................................................TAALQAWDTAGAGSPLLVVGPRLHPSSAETLRARGLWYIDGAGNAYLRHQGGLLIDVRGRRSAVSAQPGTLGDGLHSDGPRNPFTPKRAQVVCVLLDAPQLPLRAIAASAGVSVGMAKETMDTLRTTGFFEHLGSRRRLV-----RTDELLDLWA 212
25 -12.500[K] COG5625 Predicted transcription regulator containing HTH domain  ali follow..  19  19......................................................................................................................................................................................LKKNEIRIYRLLVEKRRGMRIREIQRELGISERSVRTHVLNLYRRGLLKRELGWLGYIYTPVS.......... 84
26 -12.000[K] COG1695 Predicted transcriptional regulators  ali follow..  15  7.............................................................................................................................................................................................KALVLLSKKPRQMSKEISTGVQVSHGTLMPMIRKLLQERYIDFETRGREKVYHLTERGSRFVES.. 73
27 -11.900[S] COG4519 Uncharacterized protein conserved in bacteria  ali follow..  16  12.............................................................................................................................................................................................YLALLVESLERPNVPKLIEKTGWPRRTIQDVIKAMPGIGIEQDGRRHNDGYYQLSD.......... 71
28 -11.500[KG] COG1349 Transcriptional regulators of sugar metabolism  ali follow..  8  1.........................................................................................................MKPRQRQAAILEHLQKQGKCSVEELAQYFDTTGTTIRKDLVILENAGTVIRTYGGVVLNKEESDPPIDHKTLINTHK-KALIAAAAVKYIHDGDS-----IILDAGSTVLQMVPLLSRFSNITVMTNS...................... 122
29 -11.500[K] COG1654 Biotin operon repressor  ali follow..  24  3.......................................................................................................................................................................................DTTVPLTLISLLADGEFHSGEQLGERLGMSRAAINKHIQTLRDWGVDVFTVPGK---YSLPEP......... 63
30 -11.200[K] COG4465 Pleiotropic transcriptional repressor  ali follow..  17  116.........................................................................................................IIGGGERLGTLILSRLQDQFNDDDLI--AEYGATVVGMEILREKAEEIEEEARSKAVVQMAISSLSYSELEAI----------EHIFEELDGNEGLVASKIADRVGITRSVIVNALRKLESAGVIESRSLGMKGTY-LNNKFLIELEN.. 255
31 -11.100[R] COG2522 Predicted transcriptional regulator  ali follow..  11  10................................................................................................................................................................................EYAAKNIFPSIRASIAKILVEEYKMSKYSVAKMLGATPTAVSYYISGKRGEKFVDRIIRDEEIYSIVREAASLLVEA.. 86
32 -10.700[K] COG1675 Transcription initiation factor IIE, alpha subunit  ali follow..  18  6........................................................................................................................................................................TTGVEELLNELVGRAAGEVGLILF-SLGIEGEFTDDQLSLELGIEINEIRKALFALYEIGLADYVRRWMEYYWRINYDKALDVLKR. 96
33 -10.600[K] KOG3517 Transcription factor PAX1/9  ali follow..  12  19........................................................................................................RPLPNAIRLRIVELAQL--GIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSK-----------------RVTTPTVVKHIRTYKQRDPGIFAWEIRDRLKYNVPSVSSISRILRN............................. 129
34 -10.600[K] COG3682 Predicted transcriptional regulator  ali follow..  15  4............................................................................................................TAAEAHVMEALWRRSPLSADELVAEVSWGEATVKTLINRLLKKKAIKSERAEGKHGYRPRSAYVQAESQGLLDRLFDGQLAPLISHFAQHRPLKPDEVAKLKKL........................................... 114
35 -10.300[K] COG1378 Predicted transcriptional regulators  ali follow..  15  3...............................................................................................................................................HACLIEIKKVYNFV-------------TFVVTMDEIIEVLKRDYEARVYATLATRGEATASEIHRVSGVPRNKVYEVLRSLEDRGMIETIKSSPAVFRAIDPESV....... 99
36 -10.300[T] COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases  ali follow..  16  75..........................................................................................................TLEDGRRQILNYVM--PG----DLVGLQGTVMGEMEHSVEALSPVTLCVFERSRAFDLTWIAASEERMLDNHLLSIGRRTAIERAAYLIAF--PVTQQHVADTLGLSIVHTNKTLRKLVDRGLIRWIDK.................... 223
37 -10.200[K] COG1733 Predicted transcriptional regulators  ali follow..  15  13................................................................................................................................................................................SMAAEVLCTRWTMVLMRELVAGS-TRFNDLRRGVKMSPTLLSQRLKELELAGIVERKGEKGIFDYRLTEPVVEAMGFWG 100
38 -10.100[K] COG1522 Transcriptional regulators  ali follow..  23  7........................................................................................................................................................................................DKIDRKILEVLQSNGRLTNLEVAERVNLSPSPCLRRIRRLEESGVIR........................ 53
39 -10.000[T] KOG4603 TBP-1 interacting protein  ali follow..  8  1...................................................................................................MSKGRAEAAAGAAGILLRYLQEQNRPYFGNLQREHGLGKAVVVKTLEQLAQQGKIKEKMYGKQKIYFADQDQFDMVSDADLQVLDGKIVA----------TAKVQSLQQSCRYMEAELKELSSALTTPEMQKEIQELKKECAGYRERLKNI..... 147
40 -9.980[S] COG3177 Uncharacterized conserved protein  ali follow..  11  232............................................................................................................CSDRNRYYEMLSQADKGTEEDLEA--------CTYVLSGISRE--LQKVDKLTSQQFLNENILFPAIQYSQKRQFINEDEAKILRFAVEQREFKAGDLAKLFSMNANQRTYQIKKLVESGFISPLEENSRIYIYLIRGVIYALRE.. 374
41 -9.810[C] COG1145 Ferredoxin  ali follow..  15  1.......................................................................................................................................MHHSHHLEIYEKLRE--KLNKAPIG--------PKTVSGVEKELLSVLFDEEEAKIAVHM-PFIRFTAEQLAERTGKSLEYVEKILNEMAKKGTVWKGEKDGQTYYRLFPVIVGFAE... 107
42 -9.800[S] KOG4608 Uncharacterized conserved protein  ali follow..  14  99................................................................................................................RAVCHVIKATRGITLGELCGKVKIAKEQIAEILADLSGAAQILAAGVDEKRWVMPEPRPWIAPEGCISLPVVRWMAESALVLIVSKLGIQLKDVITTYEVQPIAIREIVRKEKSAKKSPK....................... 237
43 -9.590[K] COG3327 Phenylacetic acid-responsive transcriptional repressor  ali follow..  20  15.......................................................................................................................................................................................VPVSGTSLISSLYGDWLGSLAALLEGLGFGERFVRTALFRLNKEGWLDVSRIGRRSFYSLSDKGLRLTRR.. 93
44 -9.590[K] COG2188 Transcriptional regulators  ali follow..  12  14.............................................................................................................KVKDYILANIGTGKDRKLNELVASLGVSRMTVHRALRELTAAGFLIRLQGVGTFIAPPRPQSTLIEINNIAAEIVERGNRHRSEVLVLETIMPTKELALSFEFPKRVAIYHSVVVNFENDLPVQLEERFVNPSLIPDYDK...... 159
45 -9.320[K] KOG2593 Transcription initiation factor IIE, alpha subunit  ali follow..  11  9....................................................................................................................................................................FYDNYTPKNNNQKKSAKNGSGGIAVLVLDALTRRQWVREEDLAKELKLNTKQLRTILRYFEEQQFIMRVKVHMYSYCCLDYSQIYDVIRY. 116
46 -9.260[K] COG1414 Transcriptional regulator  ali follow..  10  22.................................................................................................................DILELLASDGGLTQAEIAKHLDRSPNEFYRMLDRLVKRGYVTKLDGDRYSQLHAPVRRLASFATPFMRELADRSKQANQLAVFDRGSV--------VVIAQQEAPDYWGISIRVG-LFDTGSGHVLLAFRSPEEREMM.... 164
47 -9.080[K] KOG2587 RNA polymerase III (C) subunit  ali follow..  9  18............................................................................................................GSVVSKVCECLLRKGPLSSRDISRLADINHNKVKDILYLLIQHNCVQGSESKAIVQYIVLFNNILHRVRRIVNEELDSKCGAVLDGLLSNGRLTLGQFIERDTIGSEAIRDSLQKLVAARFVER....................... 161
48 -9.060[K] KOG3862 Transcription factor PAX2/5/8, contains PAX domain  ali follow..  10  24........................................................................................................RPLPEVVRQRIVDLAHQ--GVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSK-----------------KVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQ.................. 138
49 -9.010[R] COG1672 Predicted ATPase (AAA+ superfamily)  ali follow..  17  133.........................................................................................RIFLIICGSSISMMEKLLGYKSRRTGQINLKPVDFLHAREFLPGYSLEDGGSPAHLLEFDDSKTIKENLL---EYLRSDSLLYQDAFFVLREELEEPRNYFAIMEAVAAGKTSLGEIMNETGLSRATVAKYLSVLIELDFVKRSRKSRRGRYYIKDNYFAFWFRY. 312
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.