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anford Burnham Prebys Medical Discovery Institute

Query: [C] COG2441 Predicted butyrate kinase, from COG0516

Results of FFAS03 search in COG0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MISAGIDPGTGSYDVVAIEDGKVVFRKNIPTEEVRASPDVIVEVIEESGAEVAAGLSGYGLPVKRFSELDEVDLLLMTLNFDSERAIGLRNIIKAVKERNVNLYTVPAVIHLPTVPPWRKMNRIDIGTADKLCSAVLAVAKLSEEEELTKLNFILAEVGEGFNAFIAVRNGRIVDGMGGTTSFPGYSSLGAMDAELAYIIGEFPKKLIFSGGVKSFASEWKVNENEVTNILSEFVLKGIRAMEVSTDADFYMLSGRFAPDVLRKLRGEGKEVRLLGGFGRGKQSAQGAAIIANAIAGGEYREIVDYMRIFEAKGTLLDYITSDIMEYVRRGLKRRGDLast
1 -112.000[C] COG2441 Predicted butyrate kinase  ali  100  1MISAGIDPGTGSYDVVAIEDGKVVFRKNIPTEEVRASPDVIVEVIEESGAEVAAGLSGYGLPVKRFSELDEVDLLLMTLNFDSERAIGLRNIIKAVKERNVNLYTVPAVIHLPTVPPWRKMNRIDIGTADKLCSAVLAVAKLSEEEELTKLNFILAEVGEGFNAFIAVRNGRIVDGMGGTTSFPGYSSLGAMDAELAYIIGEFPKKLIFSGGVKSFASEWKVNENEVTNILSEFVLKGIRAMEVSTDADFYMLSGRFAPDVLRKLRGEGKEVRLLGGFGRGKQSAQGAAIIANAIAGGEYREIVDYMRIFEAKGTLLDYITSDIMEYVRRGLKRRGD 337
2 -60.700[S] COG4020 Uncharacterized protein conserved in archaea  ali follow..  17  1MTFIGVDHGTTAMRFALIEDEKVLTFELGRAEAAAMSEKEILAAIEREDIDLVALTYSMGDGFSAIKDVRKEGRGLQSIEGAGKKTGGGTRVFDAVRNSEIPAIAIPGLHSGSRVDPRMKV-FSHLTSPEKLGIAYHILC-------LGYEDFVVSDISSN-TVTLAVVAGKVIGAIDACIFAPGVHH-GPLDLQAIRNVRLQTANQAFEAGTLKMTPYKDREELLALDTIALFAAMEIASMQLLGTTGTVFLAGSVGEKKICTHLD--QECLSLGKW----HAAIGCAEIARDVSAGK----------KQILGVNVDY.................. 324
3 -36.500[C] COG3426 Butyrate kinase  ali follow..  19  3YDVLTINPGSTSTKLAVYHGDKVLFEETVRHEQFDFRWQVLRRVIDAFGYDAVVGRGGLLRPVAGGTYVTEKMLADLKNNKYGEHASNLGAMLAKADKLGIPSFIVDPVVVDEMQPVARFSGNELIARKHALNHKAAGRKAKELGSEYEKMNFVIAHLGGGI-SVAAHRQGKAVDVNNAGDGPFSPERSGSLPMNDFWTKRELHELIVGRGGMISYLGTNSEDAIKAFDAMAYQVSKEIGACSVVGKIDAIILTGGLARSEIIEQTNWIARVIIEPGEDELEALNSGVQRVLAGIEKEKVY.................................... 355
4 -11.000[KG] COG1548 Predicted transcriptional regulator/sugar kinase  ali follow..  14  41MSSLGIDIGGANLKVASKDGWEIIY------REAERLEGKLREIAEKYSTAKAG--------VVMTAELADF----------KSRAEGVEFIAKACKKAFEDVRFLDV-------------NLKSDIDNPENFAASNWVASCRFLLEEAYRNFLFVDMGSTTTDIIPVTSKIEAAKTDFERLKRGLIYFGVL-ADVFVTTGDIKEEDYSCDTPDGKGRSREECALEAKWAMIDRLSEVIEHKSKIYGLKTVFACGILIAEACEEAGAECRLISELYGDYSKLFPAYAMLKLVEQ........................................... 354
5 -10.900[KG] COG1940 Transcriptional regulator/sugar kinase  ali follow..  15  46TVRIGIDLGGTKTEVIALGAGEQLYRHRLPTDDYRQTIETIATLVDMAEQAT-RGTVGMGIP------------GSISPYTGVVKNANSTWLNGQPFDKDLSARLQREVRLANDAN-------------------CLAVSEAVDGAAAGAQTVFAVIIGTGCGAGVAF-NGRAHIGGNGTAGEWGHNKQGCIETGFATDYRRLSGHALKGSEIIRLVEESDPVAELALRRYELRLAKSLAHVVNILDPDVIVLGGGMSNVDRQFVFGGECETPVRKAKHGDSSGVRGAAWL.............................................. 344
6 -10.700[C] COG0282 Acetate kinase  ali follow..  16  4KLVLVLNCGSSSLKFAIIDDGSKQEAALGAGAAHSEALNFIVNTILAQKPELSAQLTAIGHRIVHGGEKYTSSVVIFAPLHNPAHLIGIAEALKSFPQLKDKNVAVFDTAFHQTMPEESYLYALPYSLYKEHGVRRYGAHGTSLNKPVEELNIITCHLGNG-GSVSAIRNGKCVDTSMGLTPLEGLVRSGDIDPAIIMSVDQINKMLTKESGLLGLTEVTKEDAKRAMDVYCHRLAKYIGSYTALGRLDAVVFTGGIGENAAMVRELSLGKLGVL.............................................................. 352
7 -8.580[E] COG4820 Ethanolamine utilization protein, possible chaperonin  ali follow..  12  32...LGVDLGTCDVVSMVVDRDGQPVAVCLDWADV------VRDGIVWDFFGAVTIVRRHLDTLEQQFGRRFSHAATSFPPGT-----DPRISINVLESAGLEVSHV---------------------LDEPTAVADLLQLD----------NAGVVDIGGGTTGIAIVKKGKVT-ATGGHHISLTFAGNRRISLEEAEQYKRGHGEEIWP----------------TVKPVYEKMADIVARHIEGQGITDLWLAGGSCPGVAELFRKQFPALQVHLPQHSLFMTPLAIASSGREKAEGLYAK................................... 278
8 -7.620[E] COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition  ali follow..  11  6LLSVGIDIGTTTTQVIFSH--EFIKREISWQSPVFFTPVDKQGGLKEAELKSLILEQYQAAGIAP----ESVDSGAIIITGESAKTRNARPAVMALSQSLGDFVVASAGPHLESVIAGHGAGAQTLSEQRL-------------------CRVLNIDIGGGTANYALFDAGKISGTACLNVG-------GRLSQGRVVYAHKPGQMIVDECFGAGTDVRTGAQLVQVTRRMAELIVEVIDGLPAGVTPEIITLSGGVGEATALHDHPRLREMNVQFPAQTVRATVIGAGAHTLSLSGSTIWLEGVQLPLRN-----LPVAIPIDETDLVSAWQQA.. 357
9 -7.410[S] COG2410 Uncharacterized conserved protein  ali follow..  15  1.MYCGIDVGLKKCHAALISDRLEFVG--------------DYTELDLDNVRVTGIDAPLSFPAKGSLRECERLLL-SGAPFFRGIALRGMEIAEELRSKGVEVYVYPYATRVILNIAPKAKKHTKSGLEEIR--AELSRWVEIPELSHDEVDAVIAALTVGMGVKLEGIDGSIV................................................................................................................................................................... 170
10 -6.550[G] COG3734 2-keto-3-deoxy-galactonokinase  ali follow..  10  31..FIAVDWGTTSFRLWLLSRSGAVLAETAMRTGFADVLQAHLDAIGAPADLPVLVCGMAG---------ARQGWVEAGYIDVPASLSAVLEGAVRVPGQTRDVRILPGLAQRDK-------GAPDVMRGEETQLLGALSSGDSGE---------LVCMPGTHSKWVTVKDGGVTR--------FATFMTGEL---------EAISKQTILSHAVAEAEAFTGEHEAFTAAVRDIYAHPELATNRLFTLRSGQLLHGLAATDAKARLSGIMIGLEIAGAHSQAKRETPVVLIGSGALGALYEGAFTALDIH........................... 306
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Ye Y, Li Z, and Godzik A. Modeling and Analyzing Three-Dimensional Structures of Human Disease Proteins Pacific Symposium on Biocomputing 11:439-450(2006) [PDF]