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COG2089
Query: [M] COG2089 Sialic acid synthase, from COG0312

Results of FFAS03 search in COG0312
Master-slave alignment does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MQIKIDKLTISQKNPLIIPEIGINHNGSLEIAKLMVDAAKRAGAKIIKHQTHIVEDEMSQEAKNVIPGNANISIYEIMEQCALNYKDELALKEYVEKQGLVYLSTPFSRAAANRLEDMGVSAYKIGSGECNNYPLIKHIAQFKKPMIISTGMNSIESIKPTVKILRDYEIPFVLLHTTNLYPTPSHLVRLQAMLELYKEFNCLYGLSDHTTNNLACIGAIALGASVLERHFTDTMDRKGPDIVCSMDESTLKDLINQTQEMVLLRGDNNKNPLKEEQVTIDFAFASVVSIKDIKKGEILSMDNIWVKRPSKGGISAKDFEAILGKRAKKDIKNNIQLTWDDFELast
1 -121.000[M] COG2089 Sialic acid synthase  ali  100  1MQIKIDKLTISQKNPLIIPEIGINHNGSLEIAKLMVDAAKRAGAKIIKHQTHIVEDEMSQEAKNVIPGNANISIYEIMEQCALNYKDELALKEYVEKQGLVYLSTPFSRAAANRLEDMGVSAYKIGSGECNNYPLIKHIAQFKKPMIISTGMNSIESIKPTVKILRDYEIPFVLLHTTNLYPTPSHLVRLQAMLELYKEFNCLYGLSDHTTNNLACIGAIALGASVLERHFTDTMDRKGPDIVCSMDESTLKDLINQTQEMVLLRGDNNKNPLKEEQVTIDFAFASVVSIKDIKKGEILSMDNIWVKRPSKGGISAKDFEAILGKRAKKDIKNNIQLTWDDFE 343
2 -17.100[E] COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase  ali follow..  15  77..VNVKDVEIGSKKVIVAA--GPCAVENEEQVLTTAKAVKRAGASLLRGGAYKPRT-------------------SPYSFQGLGEEGVKILRRVGDEVGLPIVTEIMDTRDSNIFSQY-VDMIQIGARNAQNFSLLKEVGKLGKPVLLKRGMGTVEEWLQAAEYILLEGNGNTVL-IRTFEKSTRFTLDIGGMVAAKLMTHLPICADSHPAGKRLALAAVAAGADLIEVHPHPEKALS--DSEQQLTPESFEVLMNRIRTLARALGR............................................................................ 329
3 -15.000[M] COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase  ali follow..  10  6..VHVGDIPVANDKPFTLFAVLESRDLAMQICEHYVKVTDKLGIPYVFKASFDKANRSSVHSYRGPGLEEGMKI----------------FQELKETFGVKIITDVHTEAQAQPVADV-VDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQMSPGQVGNIVEKFAECGNKVILCERGSCHGYDNLVVDMLGFGVMKQA-AASGGRREQTVELAKAGLATGIAGLFIEAHPNPDKARC--DGPSALPLDKLEPFLAQMKALDDLIKS............................................................................ 276
4 -8.470[E] COG0710 3-dehydroquinate dehydratase  ali follow..  13  4..LTIKGVSIGEGMPKIIIPLMGK---TEKQILNEAEAVKLLNPDIVEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLESAIQTKDIDLID------IELFSGDANVKALVSLAEENNVYVVMSEKTPVKDEIISRLRKMQDLGAHIPKMAVMPNDTGDLLTL-LDATYTMKTIYA-IITMSMAATGLISRLSGEVFGSACT---FGAGEEASAPG---QIPVSELRSVLDILHKNTRG............................................................................... 255
5 -7.620[S] COG3589 Uncharacterized conserved protein  ali follow..  16  2....................YGYSNRDLNEKDYLYIDKMTNHGFKGIFTSMHIPE-----------------------DEASLYKKRLIDLGTAAKKNHLKLMVD-CSIDRVEELQELGVTGLRMDYH--------ETIAQVSQKMTVSLNASTIRQ--EDIDELKEYKANFNLEAWHNYYPRPETGLSRESFLRKNEFLK--FKVMAFIPGDDSLRHPLYEGLPTLEAH-LLDMESLNIDHIYGLKARTAWQINQYLQELQATQATNDFAKVLGEHENRQDDARDVIRSAERKKGSITIDNCEYGRYMGEIQITKRNLPNVVGNIIKEDLELISFIG..... 339
6 -6.540[R] COG0434 Predicted TIM-barrel enzyme  ali follow..  10  31............................IDRAISDAAKYQEAGFDAIILENY-GDFPYSKTVGKETVSAFSVVANEVKREIALPL---NVLRNDCIAAYSIAYSIKADFIRVNVLTGVAFTDQGIVEGCARELAELRTRLPSRIDVLADVHVKHATHFSNFENALLDTIERGGADAVIVTGSRTGSEVDIQELITAKRISPVPVGVNPRNIKLFWRYSGFIVGTWVKEG-----------RTINEVSIERATKLAKLVKSLRE................................................................................ 258
7 -6.520[NO] COG1261 Flagellar basal body P-ring biosynthesis protein  ali follow..  15  103......................................................................................................................................................................................................................................................................................QVQVSGRYAVAVRRLAAGEKISAQDIQMKQGRLDTLPPGALHFAQGAVSQRQINAGQPLTRNMLR 170
8 -6.430[I] COG0821 Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis  ali follow..  13  16.RIYVGDVPIGDGAPIAVQSMTNTRTTDVAATVAQIKSLEKVGADIVRVSVPTMEAA-------------------------------EAFKLIKQQVSVPLVAD-FDYRIALKVAEYGVDCLRINPGNIGNEARIRSVVDCARPIRIGVNGGSLEKVESAVDILDRLNFDQFKVSVKAS--DVFLAVDSYRLLAKKIDQPLHLGITEAGGARAGSVSAVGLGMLLAE----------GDTLRISLAADPVEE-IKVGFDILKSLRIRSRGINRQEFDVIGTVNALEQRLEDVLTPMDVSIIGCVVNGPGEAGLAGSNKKSAFGVRQKERFDNDDLVA..... 349
9 -6.020[J] KOG2335 tRNA-dihydrouridine synthase  ali follow..  9..VKIFEINKGKRPVHIAAPMV----RYSKLPFRQL--VRDYNTDIVYTPMILAKEFLHPKGRYFDFSTNDADASLILQFGVDDPVILEKAAQLVGP----------YVDGIGI--NCGCPQTWAGSALLDEPEKVHKLVRAGESFCTEVKIRIAKDLNKTRHLIEKSGADIITVHGRTRQDRSSFPVNLDAIREVRPCVQIPVGIAKYTETQGIMSARGLLEFHLFYHHLTMMGQMTTKRERMTIPKDSFASVMDWLDEHFVVRRPDEPMFGESVLPCRRY............................................................. 326
10 -5.900[G] COG3010 Putative N-acetylmannosamine-6-phosphate epimerase  ali follow..  13  1MSKLSHPQVLEQIKYGLIASCQPVDNGPMEIVAAMAQASVIGGAAGLRIEGIENLKATRNVQDIEELAAAGADIIAFDGTDRVRPTTREAIIKRIKELGCLAMADCSNFEEGMYCHNLGVEIIGSTMSGYTDYQLVKDLNAAGCRVMAEGRYNTPELAKTAIEI----GAYSVTVGSALTRLEHIVSWFADAVKSAK.................................................................................................................................................. 228

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Grynberg M, Jaroszewski L, Godzik A. Domain analysis of the tubulin cofactor system: a model for tubulin folding and dimerization. BMC Bioinformatics. 2003 Oct 10;4(1):46.