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Query: [M] COG2089 Sialic acid synthase, from COG0516

Results of FFAS03 search in COG0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MQIKIDKLTISQKNPLIIPEIGINHNGSLEIAKLMVDAAKRAGAKIIKHQTHIVEDEMSQEAKNVIPGNANISIYEIMEQCALNYKDELALKEYVEKQGLVYLSTPFSRAAANRLEDMGVSAYKIGSGECNNYPLIKHIAQFKKPMIISTGMNSIESIKPTVKILRDYEIPFVLLHTTNLYPTPSHLVRLQAMLELYKEFNCLYGLSDHTTNNLACIGAIALGASVLERHFTDTMDRKGPDIVCSMDESTLKDLINQTQEMVLLRGDNNKNPLKEEQVTIDFAFASVVSIKDIKKGEILSMDNIWVKRPSKGGISAKDFEAILGKRAKKDIKNNIQLTWDDFELast
1 -129.000[M] COG2089 Sialic acid synthase  ali  100  1MQIKIDKLTISQKNPLIIPEIGINHNGSLEIAKLMVDAAKRAGAKIIKHQTHIVEDEMSQEAKNVIPGNANISIYEIMEQCALNYKDELALKEYVEKQGLVYLSTPFSRAAANRLEDMGVSAYKIGSGECNNYPLIKHIAQFKKPMIISTGMNSIESIKPTVKILRDYEIPFVLLHTTNLYPTPSHLVRLQAMLELYKEFNCLYGLSDHTTNNLACIGAIALGASVLERHFTDTMDRKGPDIVCSMDESTLKDLINQTQEMVLLRGDNNKNPLKEEQVTIDFAFASVVSIKDIKKGEILSMDNIWVKRPSKGGISAKDFEAILGKRAKKDIKNNIQLTWDDFE 343
2 -17.000[E] COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase  ali follow..  15  77..VNVKDVEIGSKKVIVAA--GPCAVENEEQVLTTAKAVKRAGASLLRGGAYKPRT-------------------SPYSFQGLGEEGVKILRRVGDEVGLPIVTEIMDTRDSNIFSQY-VDMIQIGARNAQNFSLLKEVGKLGKPVLLKRGMNTVEEWLQAAEYILLEGNGNTVL-IRTFEKSTRFTLDIGGMVAAKLMTHLPICADSHPAGKRLALAAVAAGADLIEVHPHPEKALS--DSEQQLTPESFEVLMNRIRTLARALGR............................................................................ 329
3 -8.460[M] COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase  ali follow..  10  5.IVHVGDIPVANDKPFTLFAVLESRDLAMQICEHYVKVTDKLGIPYVFKASFDKANRSSVHSYRGPGLEEGMKIFQELKE----------------TFGVKIITDVHTEAQAQPVADV-VDVIQLPAFLARQTDLVEAMAKTGAVINVKKPFMSPGQVGNIVEKFAECGNDKVILQASNGSPIIFDVTH--SLQMRDPSGAASGGRREQTVELAKAGLATGIAGLFIEAHPNPDKARC--DGPSALPLDKLEPFLAQMKALDDLI.............................................................................. 274
4 -7.110[S] COG3589 Uncharacterized conserved protein  ali follow..  17  10.........................RDLNEKDYLYIDKMTNHGFKGIFTSMHIPEDEASLYKKRL-----------------------IDLGTAAKKNHLKLMVD-CSIDRVEELQELGVTGLRMDYH--------ETIAQVSQKMTVSLNASTIRQ--EDIDELKEYKANFNLEAWHNYYPRPETGLSRESFLRKNEFLK--FKVMAFIPGDDSLRHPLYEGLPTLEAH-LLDMESLNIDHIYGLKARTAWQINQYLQEGELVLQATQATNDFAKVLGEHENRQDDENTIERKKGSITIDNCEYGRYMGEIQITKRNLPNVVGNIIKEDL............ 332
5 -7.100[E] COG0710 3-dehydroquinate dehydratase  ali follow..  13  4..LTIKGVSIGEGMPKIIIPLMGKTEKQI---LNEAEAVKLLNPDIVEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLESAIQTKDIDLID------IELFSGDANVKALVSLAEENNVYVVMSNKTPVKDEIISRLRKMQDLGAHIPKM---AVMPNDTGDL-LDATYTMKTIY--IITMSMAATGLISRLSGEVFGSACT---FGAGEEASAPG---QIPVSELRSVLDILHKNTRG............................................................................... 255
6 -6.300[I] COG0821 Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis  ali follow..  14  16.RIYVGDVPIGDGAPIAVQSMTNTRTTDVAATVAQIKSLEKVGADIVRVSVPTME--------------AAEAFKLIKQQVSVP----------------LVADIHFDYRIALKVAEYGVDCLRINPGNIGNEARIRSVVDCARPIRIGVNGGSLEK-EPTPEALVESAMRHVDILDRLNFDQFKVSVKASDVFLAVDSYRLLAKKIDQPLHLGITEAAVGLGMLLAE----------GDTLRISLAADPVEE-IKVGFDILKSLRIRSRGINRQEFDVIGTVNALEQRLEDVLTPMDVSIIGCVVNGPGEAGLAGSNKKSAFGVRQKERFDNDDLVA..... 349
7 -5.710[H] KOG3243 6,7-dimethyl-8-ribityllumazine synthase  ali follow..  16  30.....................................................................................................VIIDALVKGAIERMASLGVEENNIGSYELP--RFVDRQAKLGKPLVIPIGVLIKGSTMHFEYISDSTTHALMNLQEKVDMPVIFGLLTCMTEEQALARAGIDEAHSMHNHGEDWGAAAVEMAVKFGKNAF................................................................................................................ 169
8 -5.580[R] COG1489 DNA-binding protein, stimulates sugar fermentation  ali follow..  13  19.................................................................................................................FLADVITPDGTTLTLHCPNTGAMTGCATPGDTVWYSTSENTKRKYPHTWELTETQSGAFICVNTLRANQLTKEAIQENRLPALANILKSEVKYGAERSRIDFMLQADFRPDCYIEKSVTLAEKENGPDAITERGQKHLRELMGVAAAGHRAV.............................................................................. 175
9 -5.420[R] COG1242 Predicted Fe-S oxidoreductase  ali follow..  12  44.......................NRDGTVAHGGCTFCSAAGSGALDLKVQFQQVRDKMQTKWKDGKCIAYFQAFTNTHAPVAELREKFETVLNEPGVVGLSIATRPLPDDVVEYLAELN----------------------ERTYLWLELGLQSAHDYLEGVRKLQKHNIRICT-HIINGLPKETPEMMMETAQKVVES---------GVDGIKIHLLHLLKGTPMVEDYKKGDLEFLTRDGYVNLVADQLEILPPEM--IHRITGDGGVDDLSLNKFEVLNAIDAELVRRDSWQGKLYQPVEVSSK.................................... 321
10 -5.270[NO] COG1261 Flagellar basal body P-ring biosynthesis protein  ali follow..  16  101....................................................................................................................................................................................................................................................................................QTQVQVSGRYAVAVRRLAAGEKISAQDIQMKQGRLDTLPPGALHFAQGAVSQRQINAGQPLTRNMLR 170

FFAS is supported by the NIH grant R01-GM087218-01
8 5 6 5 9   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Slabinski L, Jaroszewski L, Rychlewski L, Wilson IA, Lesley SA, Godzik A. XtalPred: a web server for prediction of protein crystallizability. Bioinformatics. 2007 Dec 15;23(24):3403-5. Epub 2007 Oct 5.