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COG1014
Query: [C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit, from COG0312

Results of FFAS03 search in COG0312
Master-slave alignment does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst TFQCKFWGFGSDGTVGANKAAIKIIGDNTDLYAQGYFSYDSKKSGGLTVSHLRFGENRIRSAYLIQQADFVSCSTSAYLRSYDLLKGLKPGGTFLLNTIWEGEQLERHLPAAMREYIAKNNIQFYTLNAMRIAGEAGLGRRINTVMQTAFFRVTDILPFEKALADLKASAIATYGKKDMAVAEKNILAMDQTVANLHKVEVPESWANPVLTAEASTATEKPAYVKNILEPVNRLEGDNLTVGDLISNGMVSGAYPPGTAAYEKRGIALEVPEWISENCTMCNECAFVCPHAAIRPILTNEEEMESAPEGFMTREMRGKDGLRYRIQVSPMDCTGCNLCAETCPAKDKALVMKPFEEVAAKENPNWSFAINVKPKKNPGKKNTVPGLast
1 -144.000[C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit  ali  100  1TFQCKFWGFGSDGTVGANKAAIKIIGDNTDLYAQGYFSYDSKKSGGLTVSHLRFGENRIRSAYLIQQADFVSCSTSAYLRSYDLLKGLKPGGTFLLNTIWEGEQLERHLPAAMREYIAKNNIQFYTLNAMRIAGEAGLGRRINTVMQTAFFRVTDILPFEKALADLKASAIATYGKKDMAVAEKNILAMDQTVANLHKVEVPESWANPVLTAEASTATEKPAYVKNILEPVNRLEGDNLTVGDLISNGMVSGAYPPGTAAYEKRGIALEVPEWISENCTMCNECAFVCPHAAIRPILTNEEEMESAPEGFMTREMRGKDGLRYRIQVSPMDCTGCNLCAETCPAKDKALVMKPFEEVAAKENPNWSFAINVKPKKNPGKKNTVPG 385
2 -21.900[C] KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit  ali follow..  15  2...................................................................................................................................................................................SLTMRIFTASRNGQRLFGSHGARLLAAQRAEPKDIVEVPKGYVYVNNKELSMEFADITDRAASTMFFGELLRG-FAVTLAHIFKEPATINYPF-GEERCIACKLCEAICPAQAI---------------TIEAEERADGSRRTTRYDIDMTKCIYCGFCQEACPV--DAIVEGPNFEFSTETHEELLYNKEK.............. 194
3 -20.900[C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit  ali follow..  28  31...............................................................................................................................................................................................................................................................GTTLVNFTGDWRTFMPVIDESKCVKCYICWKFCPEPAIY---IKEDGFV---------------------AIDYDYCKGCGICANECPT--KAITMVREEK............................. 105
4 -19.800[C] COG1146 Ferredoxin  ali follow..  15  31......................................................................................................................................................................................................................................................................DRKEIEWYPTIDYDKCVTCGICFVTCGRRVFD---------------------FDKKEGKVIVARPYNCMVACQTCMNLCPTG--AISFPDASYIKKLVAQ...................... 108
5 -18.900[C] COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB  ali follow..  18  1.................................................................................................................................................MNAIWIAVAAVXLLGLAFGAILGYASRRFAVEDDPVVEKIDEILPQSQCGQCGYPGCRPYAEAISCNGEKINRCAPG-------------GEAVMLKIAELLNVEPQPLDGEAQELTPARMVAVI---DENNCIGCTKCIQACPVDAIV-------------------------ATRAMHTVMSDLCTGCNLCVDPCPT--HCISLQPVAETPDSWK....................... 175
6 -18.000[C] COG1145 Ferredoxin  ali follow..  12  5................HHLEIYEKLREKLNKAPIGLPKTVSGVE--KELLSVLFDEEEAKIAVHMTAEQLAERTGKSLEYVEKILNEMAKKGTTPFWPGPGKDPRQEKLARLWSQYRKEGFLDEIGDREHPIMRALPERDTISE---------SEILPYEDAVKLVKEAVGYCPCRVMARLVG---EGCRHSIENCIHMGSVGKYMVEHGLGRRISADEAIEILRQSNREGLVHLTERSKHVATICNCCSDCCVFFKAVHEAKHP-SSYLATVDTSRCIACGICMLRCPMKAIK-----------------------AKINREPASVDAEKCLGCGVCVPTCPME--AIELVERDELLE.......................... 345
7 -17.800[C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)  ali follow..  22  3.............................................................................................................................................................................................................................KEIINVVHGTFTQRSLVMIFGHAFRKRDT--QYPEEPVYLPPR-IVLTRDPDGEERCVACNLCAVACPVGCISLQKAETEDGRWYPEFF---------------RINFSRCIFCGLCEEACPT--TAIQLTPDFEMGEFKRQDLVY.................. 134
8 -15.300[C] COG1141 Ferredoxin  ali follow..  17  50.................................................................................................................................................................................................................................................................................DEITCIGCKHCAHVARNTFY---------------------IEPDYGRSRVIRQDGDAEEVIQEAIDTCPVD--CIHWVDYTELKNLEED...................... 116
9 -15.300[C] COG0348 Polyferredoxin  ali follow..  11  38............................................................................................MFLSGPYFGVWILKGNYSSSLLLDLIPMTDPLIMAESLATGFMPTMTALLGALIVVVLYAILGVCPLNIVTDASAWLRRKLEIRQSAKLPRSLRYAI------VMILLGSALSGLLLWEWLNPVAALGRALIYGFGATVWLVLAVFLFDLFIVEHGWCGHLCPIGAAGVIGAKGLFRIKVEHRQQCDNCMDCYNVCPEPQVLRDPLHAKKSESP-------------------LVLSKDCISCGRCIDVCPEKVFIFTTRFNHSVNHSGE....................... 291
10 -14.600[C] COG1150 Heterodisulfide reductase, subunit C  ali follow..  20  37.................................................................................................................................................................................................................................................................................SVQACYQCGTCTGSCP-TSYRTRLIMRKLQLGLVDEVIKSD-------------ELWMCTTCYTCYERCPRGVKIVDAVKAARNLAAKK....................... 115
11 -13.500[C] COG1142 Fe-S-cluster-containing hydrogenase components 2  ali follow..  15  43................................................................................................................................................................................................................................EKESAPQLCHHCEDAPCAV---------VCPVNAITRVDGAVQL-----NESLCVSCKLCGIACPFGAIEDIPANANTPKAPPAPPAPARISTLLDWVPGIRAIAVKCDLCSACVRMCPTKALHLVDNTDIARVSKRKRELTFNTDFGDLTLFQQAQSGEA 202
12 -12.700[R] COG2768 Uncharacterized Fe-S center protein  ali follow..  14  25...........................................................................................................SAVRKLEKLIDESGVLDVVSKGDVVAVKTHFGDRGTTRTLRSVFTVVEKVIEAGGRPFVTETTGLGMLRPRCTAVGRINIAEENGYTHQT-LKAPIIIADGLLGFDYVEVPVEGKHLNSVKVAKAIAECDAVICCTHFKLHMQAGGVGCVAKPSKFDIHMSDYPQIDEEKCTKCDECVKICPSNAIEDYQINREK-----------------------------CVKCLGCSEACDYGAVKTFWVFGRDVSERIVE...................... 260
13 -11.500[C] COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain  ali follow..  12  4..........KTSHLKFKPRINEEIQNDIKAVVMAQERIGANRQKMVEWEEWREHAKEIR--------NHVIENLDAYLYQLSEKVIQNGGHVYFAATAEDATNYIKNVEIGMNHVLEAEGIKVVETDLGEYILQVAEDKPSHIVVPAIHKDRHQI-TPEEMTLFIRETIRNDFLEADIGVSGCNFAVAETG-----SVCLVTNEGNLRLATSLPKTHIAVMGMERLAPTFKEVDGARLTGYNTWLTGPRLAGETDGPEEFHGRSKMLGSEFREVLRCIRCGACLNTCP------RQIGGHGYGSIYPGPIGSVISPILGGYEEFKDLPSACSLCTACNQVCPVKIPLANLLLKHRRHIAES....................... 392
14 -11.400[C] COG0437 Fe-S-cluster-containing hydrogenase components 1  ali follow..  28  80..............................................................................................................................................................................................................................................................PSGAMHKREDGFVVV----DEDVCIGCRYCHMACPYGA--PQYNAEKGHMTK-------------------------CDGC-ICVESCPL--RALEFGPIEELRQKHGT...................... 164
15 -10.200[C] COG1036 Archaeal flavoproteins  ali follow..  17  1..............................................................................MSFKSIAWGITGAGHFLDRS----------------------------YQVFKELKQRDPELSVNTYISRAAEEVLRMYGLEQKLVKI----------SGGDYLEEIFRESEQGSSSPKVGRFLLDRYDALFVTPA---------TSNTVSKIAYGIADSLVTNAVAQAVKGKVPVYVVPVDIEGSIISEMPYNIDRKQCRHCEPPRENCPHGAI------------------------TEKNGVTDQIELLKCKGCGICKELCP---NAIKGGPVEVLVRD......................... 211
16 -9.870[C] COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC  ali follow..  14  51........LGPEGELRVRAGEQVLKGQPLTVGRGRTVPVHAPTSGMITAIAPHTTAHPITPDGEDRWREQQPWADYRQRDKMALLDRIHQAGIAGLGGA---------FPTASKLQGGLNGIITLIINAAECEPYITADDRL-HILRHLLQPQQVLIGIEEAIAALQRALRGKYPSGGAKVLMQNVGTVVAIKRAVIDEPLIERVVTLTGDALSSPGNFWARIGTPVLYLLKLAGFKPQNPPMVIMGGPLMGFTSNCILAPAETEMGLSEPE---QSCIRCGLCVDACPAGLLPQQLYWFSRGEEHEK---------------ARNHNLFDCIECGACAYVCPSNIPLVQ................................... 434
17 -9.710[C] COG1148 Heterodisulfide reductase, subunit A and related polyferredoxins  ali follow..  27  586.....................................................................................................................................................................................................................................................................GEVEIEPIVAVTDSDVCGGCEVCIELCPFGAIS---------------------------EGHANVNVALCKGCGTCVAACP--SGAMDQQHFRTE............................ 654
18 -9.580[R] COG1453 Predicted oxidoreductases of the aldo/keto reductase family  ali follow..  15  1....................................MLYRKMPKNGDELSILGFGRLPVKEDGSVDEERATRQVRYAIVNYVDTAWPYHMGESVKLATK-SREDMDKFLNAQLEK-LKTDHIDYYLINVIDFFEKAKSDGRIVNAGFSFHGLANDFKRIVDAYPWTFCQIQYNFASKGLGVMIME-----RGGNLARTVPLAIENIWSEADVERTPVEWALRWVWNHPEVTVVLSGMNEEVHIKENLKIASEAYPNSLTEAELQLVSKVEQKYRQIMKVGCTGCQYCCPSGVNIPECFSIYNHLSTFGNAEDANLL-SGAVSGGKPGMASQCVQCGQCLEKCP---QHIDIPTILESVAEELEGSDLEERIAIVKQEMHKQ.... 399
19 -9.250[C] COG2440 Ferredoxin-like protein  ali follow..  15  31.................................................................................................................................................................................................................................................................................RPHERPSANLLTHICPAKCYE------------------------LNDKGQVETTSDGCMECGTCRVLCEASGEIVWNYP................................ 88

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Friedberg I, Jambon M, Godzik A. New avenues in protein function prediction. Protein Sci. 2006 Jun;15(6):1527-9.