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COG0178
Query: [L] COG0178 Excinuclease ATPase subunit, from COG0312

Results of FFAS03 search in COG0312
Master-slave alignment does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDKIEVRGARTHNLKNINLTIPRDKLIVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLSLMEKPDVDHIEGLSPAISIEQKSTSHNPRSTVGTITEVYDYLRLLYARVGEPRCPEHQVPLKAQTISQMVDKVLELPEGSKMMLLATIVKERKGEHVKTLENLAAQGFIRARIDGETCDLTDPPKLELHKKHTIEVIVDRFKVRSDLQQRLAESFETALELSGGIVVVAPMEGDGEEQIFSANFACPHCGYSMRELEPRLFSFNNPAGACPTCDGLGVQQYFDPDRVIQDANLSLAQGAIRGWDQKNFYYFQMLTALAEHYDFDVHTPFNKLSKKIQEIILHGSGRTEIEFKYINDRGDIRLKKHPFEGILHNLERRYRDTESNSVREELAKYISNKPCSSCDGTRLKIEARNVFINDTALPTIVELSIADALTFFQELKLEGQRAQIAEKVMKEINDRLQFLVNVGLNYLNLSRSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLQTLTHLRNLGNTVLVVEHDEDAIRMADHVIDIGPGAGVHGGMVVAEGNVEEIIANPNSLTGQYLSGVKKIAVPEQRTPKDAKKTVELKGAVGNNLKNVDLSIPVGLFTCVTGVSGSGKSTLINDTFFKIAHTALNGATTATPAPYRSIQGLEHFDKVIDIDQSPIGRTPRSNPATYTGIFTPIRELFAGTQESRSRGYQPGRFSFNVRGGRCEACQGDGVIKVEMHFLPDVYVPCDVCKGKRYNRETLEVRYKGKTIDEVLDMTVEDAREFFDPVPVIARKLQTLMDVGLSYIRLGQSATTLSGGEAQRVKLARELSKRDTGKTLYILDEPTTGLHFHDIQQLLSVLHRLRDHGNTVVVIEHNLDVIKTADWIIDLGPEGGQGGGLIIAEGTPEDVAQIEASHTARFLKPLLNLast
1 -266.000[L] COG0178 Excinuclease ATPase subunit  ali  100  1MDKIEVRGARTHNLKNINLTIPRDKLIVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLSLMEKPDVDHIEGLSPAISIEQKSTSHNPRSTVGTITEVYDYLRLLYARVGEPRCPEHQVPLKAQTISQMVDKVLELPEGSKMMLLATIVKERKGEHVKTLENLAAQGFIRARIDGETCDLTDPPKLELHKKHTIEVIVDRFKVRSDLQQRLAESFETALELSGGIVVVAPMEGDGEEQIFSANFACPHCGYSMRELEPRLFSFNNPAGACPTCDGLGVQQYFDPDRVIQDANLSLAQGAIRGWDQKNFYYFQMLTALAEHYDFDVHTPFNKLSKKIQEIILHGSGRTEIEFKYINDRGDIRLKKHPFEGILHNLERRYRDTESNSVREELAKYISNKPCSSCDGTRLKIEARNVFINDTALPTIVELSIADALTFFQELKLEGQRAQIAEKVMKEINDRLQFLVNVGLNYLNLSRSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLQTLTHLRNLGNTVLVVEHDEDAIRMADHVIDIGPGAGVHGGMVVAEGNVEEIIANPNSLTGQYLSGVKKIAVPEQRTPKDAKKTVELKGAVGNNLKNVDLSIPVGLFTCVTGVSGSGKSTLINDTFFKIAHTALNGATTATPAPYRSIQGLEHFDKVIDIDQSPIGRTPRSNPATYTGIFTPIRELFAGTQESRSRGYQPGRFSFNVRGGRCEACQGDGVIKVEMHFLPDVYVPCDVCKGKRYNRETLEVRYKGKTIDEVLDMTVEDAREFFDPVPVIARKLQTLMDVGLSYIRLGQSATTLSGGEAQRVKLARELSKRDTGKTLYILDEPTTGLHFHDIQQLLSVLHRLRDHGNTVVVIEHNLDVIKTADWIIDLGPEGGQGGGLIIAEGTPEDVAQIEASHTARFLKPLLN 940
2 -26.500[A] KOG0063 RNAse L inhibitor, ABC superfamily  ali follow..  21  191...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................LDERGLMEICADMELNQV-LEREARQVSGGELQRFAIAAVFVKK----IYMFDEPSSYLDVRQRLKAAQVIRSLLRHDSYVIVVEHDLSVLDYSDFVCCL--------GKPGAYGVVTLPFSVREGIN-VFLAGFIPTENLRFRDESLTFRVSETKQLGDFKLEVMEGEFTDSQIIVMLGENGTGKTTFIRMLA--------------------------------------------------------------------------------------------GAFPRE--------------EGVQSEIPEFNVSYKPQGNDSKRECTVRQLLKIRDACAHPQFMSDVIRPLQIEQL-MDQVVKTLSGGEKQRVAITLCLGKPAD---IYLIDEPSAHLDSEQRITASKVIKRFIHAKKTAFIVEHDFIMAYLADRVIVY------EGQPAVIAHSPQSLLSGMNHFL......... 563
3 -24.300[R] COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog  ali follow..  20  57...............................................................................................................................................................................................................................................................................................................................................NKCPFDAIMIIGLPEALQEPTHRYGPNGFALFGLPVPRIGKVTGI-------PNGIGKSTSVQILSGTLVPNFGQGKGDWDTVLEHYAGTALHDYFKDVVDGKVKVSQKPQYVDLIPKAFKGKTSELLEKTELIDRLDLRGV-VERKISELSGGELQRVAIAACAARD----FYFFDEISPYLDIYQRINVARLVQEISK-DRAVLVVEHDLAILDMLTDVIHIAYGEPAGFGVIVRVGINQYLKGYLPEENIRIRPEAIRFEVHPPREDAQFQSMVSFNSFSKQ-LKATGGSLREGEVLGIVGPNGIGKSTFV-----------------------------------------------------------------------------------KVLAGEIKPDEGDPGIEVKISYKP-------------------------QYIKADTPVSVQDFLRGIKRFGTSYYEVEIANPLQLERI-YESLLTELSGGELQRVAIAACLSQEAD---LYILDEPSAHLDVEQRSMVTKVINRFANNQKTAMVVDHDIYMIMLSQRLLVF--------GKPSVYGEAHGPFSMESGMN-RFLENL.. 550
4 -23.200[P] COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA  ali follow..  20  114..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................VKDAPRCMQLAQQFGITPL-LDRRFKYLSTGETRKTLLCQALMSE----LLILDEPFDGLDVASRQQLAERLASLHQSGITLVLVLNRFDEIPEVQFAGVL------ADCTLAETGAKEELLQQALVAQLAHSEQLEGVQLPEPDEPSARHNNGVVSYNDRPILNNLSWQVNPGEHWQIVGPNGAGKSTLL-SLITGDHPQGYSNDLTLFGRRRGSGETIWDIKKHIGY----------------------------------------------------------------------------------VSSSLHLDYRVSTTVRNVILSGYFDSIGIYQAVSDRQQKLQWLDILGIDKRTADAPFHSLSWGQQRLALIVRALVKHPT---LLILDEPLQGLDPLNRQLIRRFVDVLISEGEQLLFVSHHADAPACITHRLEFVPD-----GGLYHYALTKI.................. 493
5 -22.200[R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase  ali follow..  21  146..................................................................................................................................................................................................................................................................................................................................................................................................................................................ITEVLRLHLKMSKAQARAEAIE-----------LLRQVEIP--ALDRYAFQYSGGMRQRAMIAMAL--ACKPQLLIADEPTTALDVTTQAEILDLISRLQAHGMAVLFITHDMGVVAQIADDVLV-----MHHGVVKEYGTVEQIFHKPQDPYTRMLIGSVLKLEQKAEIRLARPKDLSMHFGEMKALDGVSIKLLPGETLGIVGESGSGKTTMGRSIMRLYDPTAGEMLYRRADGSVVDLSKIEGKEKAARRELRMVFQDPFGSLNPRMTV--------------------------------------------------------------------------AQVIGEPLLV------GIAKGKELEERVCSLMEQVGLDPSGRERYPHAFSGGQRQRIGIARAITLRPR---IIVADEATSALDVSVRFQVLDLLMKLQELGLAYIFISHDIGVIYMCDRVGVM------YRGKLVEVGEAEKVCNAPDPYTQALLSAI.. 562
6 -20.700[R] COG4172 ABC-type uncharacterized transport system, duplicated ATPase component  ali follow..  20  70..................................................................................................................................................................................................................................................................................................................................................................................................................................SVDYRGRNLLTLSKSDLNKSMIFQEPMTSLDPLYSIGNQLIEPIRRHLKLLRLVHIP--RMKSYPHEMSGGQRQRVMIAMAL--ANDPDILIADEPTTALDVTIQAQILMLLAELRKLGMAIVFITHDLGIVRRADRVYVM------RQGEVVEEGEAGAIFANPQHAYTKMLLAAEPTGSKAAPPANAGGGFLAGEPLMLRAVDDISIRLQRNQTIGIVGESGSGKSTLGRALL-----------------------RLLPSDGLIRFGDRDISTADRQAMRPLRR-------------------------------------------QMQLVF-----------------QDPFGSLSPRMTVGQVITEGLLVHEPNLSGKQRDQRAVEALREVGLDPNARNRYPHEFSGGQRQRIAIARAMILKPK---MVVLDEPTSALDRSVQKQIVELLRKLADHELSYLFISHDLSVVRAADYIIVM------KQGKIVEEGPTEAIFSNPQVYTQTLMAAA.. 529
7 -19.800[EJ] KOG0062 ATPase component of ABC transporters with duplicated ATPase domains/Translation elongation factor EF-3b  ali follow..  16  3........................................................................................................................................................................................................................................................................................................................................................................................................................EGIEIVNTDFSLAYGSRMLLNKTNLRLLKG----HRYGLCGRNGAGKSTLMRAIANGQAALESVGFDEERRAQTVGSLSGGWKMKLELARAMLQK----ILLLDEPTNHLDVSNVKWLEEYLLEHT--DITSLIVSHDSGFLTVCTDIIHY-----ENKKLAYYKGNLAAFVEQKPEAKSYYTLTDSNVKSNTRAVAKMTDVTFSYPGAQKPSLSHVSCSLSLSSRVACLGPNGAGKSTLIKLLT-LVPNEGKVEKHPNLRIGYIAQHALQHVNEHKEYQFGDDREVLLKESRKISEDEKEMMTKEIDIDDGRGKRAIEAIVGRQKLK--------------KSFQYEVKWKYWKPKYNSWVPKDVLVEHGFEKLVQKFDDHEASREGLGYRELIPSVIT-KHFEDVGLD-IANHTPLGSLSGGQLVKVVIAGAMWNNPH---LLVLDEPTNYL---DRDSLGALAVAIRDWSGGVVMISHNNEFVGAL........................................... 530
8 -19.400[P] COG3638 ABC-type phosphate/phosphonate transport system, ATPase component  ali follow..  23  41.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LDNINFELHAGEFVAIIGRSGAGKSTLL----------HILNGTIPTSAGEIINYHENGDTQNIAALTTKQMRKWRAKC---------------------------------------------GMIFQDFCLVPRLDVITNVLLGRLSYTSTLK---------SFFKLFSEQDQA---------RAIELLQWLNML--HALQRAENLSGGQMQRVAICRAMMQNPK---ILLADEPVASLDPKNTTRIMNTLQKISENDIAVIVNLHSVDLVKDCTRVIGI------AHGRIIFDGPPSMLNDSIQDIYSDESAELLH 278
9 -18.900[H] COG4138 ABC-type cobalamin transport system, ATPase component  ali follow..  23  16.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LGPLSGEVRAGEILHLVGPNGAGKSTLL-----------------------ARMAGMTSGKGSIQFAGQPLEAWSATKLALHRAYLS------------------------------------------QQQTPPFATPVWHYLTLHQHDKTRTELLNDVAGALALDDK-------------------------------LGRSTNQLSGGEWQRVRLAAVVLQINPAGQLLLLDEPMNSLDVAQQSALDKILSALCQQGLAIVMSSHDLNTLRHAHRAWLL------KGGKMLASGRREEVLTPP............. 224
10 -18.900[E] COG4598 ABC-type histidine transport system, ATPase component  ali follow..  29  21.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LKGVSLQANAGDVISIIGSSGSGKSTFL-----------------------RCINFLEKPSESIVVNGQTINLVRDKDGQLKVADKNQLRLLRTRL----------------------------TMVFQHFNLWSHMTVLENVMEAP----------------IQVLGLSKQEARE---------RAVKYLAKVGIDERAQGKYPVHLSGGQQQRVSIARALAMEPE---VLLFDEPTSALDPELVGEVLRIMQQLAEEGKTMVVVTHEMGFARVSTHVIFL------HQGKIEEEGAPEQLFGNPQS-LQRFLKGSLK 257
11 -18.800[R] COG3845 ABC-type uncharacterized transport systems, ATPase components  ali follow..  17  30.....................................................................................................................................................................................................................................................................................................................................................................................RGTIHGIVGENGAGKSTLMSILYGFYQADSGEIRVGGKPASIKTPNDAIALGIGMVHQHFMLVDNFSVLENIILGAESDALLKSSIAKARSELERLEREYGLEVDPDAIIEELPVGLQQRVEILKALYRGAE--ILILDEPTGVLTPAEADHLFRILKQLKEQGKTVVLITHKREIMAITDNVSVM------RQGTMVATRETSKTTVGE---LAELMVGRRVLLRVEKGEAEAGAVKLAVKNLTVKDVDDISFDLRAGEIVGIAGVAGNGQSELL-----------------------EAISGIRHAVSSVMLDGKPIDLTGAADPGE--------------------------------------------LRDRGLAHVPEDRHHVGLVLAFEENENSILGYHDDPRYLKGPFLNVDAIMADAKDK---------IEKYDIRPGNPRLKTANFSGGNQQKIVLAREMEQDPG---VLIVGQPTRGVDVGAIEFIHKRLIAMRDQGKAVLVVSVELDIRSLSDRILVM--FAGRIVGERGPEATEGELGL............... 498
12 -18.600[P] COG1122 ABC-type cobalt transport system, ATPase component  ali follow..  20  98..........................................................................................................................................................................................................................................................................................................................................................................................................................................................DELVFPLIQQGFGWGEAKREAEEV--CEELGIGGL-LERKTYELSTGELQLVQIAAALASK----ILVFDEPFANLSRKNVLKVIKILRDY-----PHLVSEHRLEFSSFFEKTINL---------------------------------------------GLECEDFEIPEVEPGEAVYDGLIELREGELIALVGDNGAGKTMM--------------------------LKKIATEMRKLGLDFSIVLQNPSY---------------------------------------------------------------------------------------HLVEDSVGKEVDL-----------ETAKEFGIESLL-SRHPQSLSMGQMKRVAIAKAFKSK-----ILLLDEPTAGQ---DCNFRRRLLYLLRKHRKSAIIATHDPYVAEHCDRKVEL..................................... 370
13 -18.600[GM] COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component  ali follow..  13  66................................................................................................................................................................................................................................................................................................................................................................................................RNLDFTGYKGEILGIIGSNGAGKTTLCKMLSGILKPDEGELYVDGRVSALFSLGMGFKKELTGRENNGMMLGIEKDQIDQFIDEIHEFSGLGSFIDQPMKYYSSGMKARLGFSVAAFLE----ILILDEALNTGDAAFGKKAAAKMKELVSKAKMVILVTHSLRYARKCDRLLWL------DRGEIRAIGEPAEVIEKYKETIPVKVRRPRKRLELKKTEANVKERTVVKAENIGMSLKNVSFDIKEGEVVGIIGHNGAGKSTL-------------------------------------------------------------CKLLTKILTPDEGELELSGETT--------------SLLSYGTGFNAQLSG-----------KDNVYLN------GMLLGIPKERVAQEYPNIVAFSELEKHM----------DKPVKSYSSGMKSRLGFSIAATLQPD---IFIIDEALSTGDVAFQQKASEKIQEMMERAKAVIIVSHSMKFVESCTRAIWL------EKGQVRFDGDPEEAVKLYKGPE......... 508
14 -18.400[E] COG4161 ABC-type arginine transport system, ATPase component  ali follow..  23  18.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LFDITLDCPQGETLVLLGPSGAGKSSLL-----------------------RVLNLLEMPRSTLNIAGNHFDFTKTPSDKAIRDLRRNV-----------------------------------GMVFQQYNLWPHLTVQQNLIEAP----------------CRVLGLSKDQALA---------RAEKLLERLRLK--YSDRYPLHLSGGQQQRVAIARALMMEPQ---VLLFDEPTAALDPEITAQIVSIIRELAETNITQVIVTHEVEVARTASRVVYM------ENGHIVEQGDASCFTEPQTEAFKNYLSH... 242
15 -18.300[R] COG4618 ABC-type protease/lipase transport system, ATPase and permease components  ali follow..  18  205.............................................................................................................................................................................................................................................................................................................................................................................................................................................................SRRNAEVVQAMGLGRRLGKRWQSSNEAYLAANRKAGDVAGGLGNLAKSLRVVLQSAILAVGAWLVIREASGGVMIASSIMMGRALAPVDLAISNWKSFVAARQSWARLRELFAQMP-------------------ANAAAMALPKPEKELRVE----------NVTIVPPGERKPTVTGLGFVVTAGNALGIIGPSGSGKSTLA----------------RILTGAWMPAAG------KVRLDGASFDQWDRETLGRHIGYLPQGVELFD------------GTIGENISRFDDNP-----------------------------------------DPEAIIAAAAAGAHELILRFEK-------------GYSDIGEAGSTLSAGQRQRIGLARALYGDPF---IVVLDEPNANLDAEGEAAVVKAITSVKARGGIAVVVAHRPSAIGAVDYILMM------EDGRMKAFGPRDEVLSKVLRVPQAQ...... 570
16 -18.100[G] COG1129 ABC-type sugar transport system, ATPase component  ali follow..  18  102............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VPLDVPVHRLSVAQQQFVEIAKALSLD----ILVLDEPTATLTPSETEHLFNVMRELRRQGVAIIFISHHDEIFEICDRITVL------RDGELIGSCLTSEVDNDREMMVGRRIE---ASFPPKPQIDPSAAKVIEVEELQLKKGPVSRFSLRKGEILGFAGLVGSGRTET-----------------------------VLAMLGAHSASRRKI-------------KLDGVDTRLSGPDDALMRGIG------------------------EEGLITSFSI--------------------LQNISLNNYRKYRKAHWFLDLKKELEHTTKAMAQVQVKAQGPYARVDTLSGGNQQKIVIARWLNHDMR---VLIFDEPTRGIDVGAKAEIYSLMREFAARGHSIIMISSELEVIGMSDRVCVF------RSGGIVATVEGEDINSETTNATTGRVEHV.. 471
17 -17.700[J] KOG0066 eIF2-interacting protein ABC50 (ABC superfamily)  ali follow..  17  368......................................................................................................................................................................................................................................................................................................................................................VNANLLIAHGRRYGLVGPNGHGKTTLLRHIATRAFAIPPNIDVLLCEQEVVATDKTAINTILEADVRRTEMLKKADELEKQFVAGDLTVQEELNDTFAELKAIGAYSAEARARR-----------ILAGLGFSKEMQDRPTNKFSGGWRMRVSLARALYLE----LLMLDEPTNHL---DLNAVIWLDNYLQGWKKTLLIVSHDQSFLDNV----------------------CNEIIHLDQKKLQYYKGNYSMFKKMYVQKRREMIKEYEKQEKRLRELKAH-----------GQSKKAAEKKQKESLTRKQEKNKSKQQKQDEDEGPQELLARPKEYIVKFRFPEPSQLQPPILGVHNVTFAFPSQKPLFIKVDFGIDLTSRVAIVGPN----------GVG----KSTFLKLLLGELEPQEGEQRKNHRLHVGRFDQHSGEHLTAEESAAEYLQRLFNLPHEKARKLGSFGLVSHAHTIKMKDLSGGQKARVALAELCLSAPD---VLILDEPTNNL---DIESIDALAEAINEYEGGVIIVSHDERLIRET........................................... 854
18 -17.700[O] COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components  ali follow..  23  229....................................................................................................................................................................................................................................................................................................................................................................................................................................SLLNFETVKYFGNEAMEAKRFDGAMARYEKAATQTWTSLGWLNFGQAVIFGAGMAIVMVMSAMEVQKG--------TQSLGDFVFINALLM-------------QLSIPLNFIGFIYREI------RQGLTDIEQMFDL--------------DVKQEVKDKPGAPALKVDSGA--ISFKDVHFAYDPQRPI---------LRGISFDVPAGKTVAIVGPSGAGKSTISRLLF-----------------RFYDIQS------SITIDGQDVRDVTQESLRKFIGMVPQDTVLFNDT------------IAYNIRYGRTDASEED----------------------------------------------VEKAAE----LAQIAGFIKHLPD---GYSMVGERGLKLSGGEKQRVAIARTILKAPP---ILILDEATSALDTATEQEIQSALDIVS-RGRTTLVIAHRLSTVIGADEIIVL------KDGLIAERGTHRHLLDQKGLYASMWDRQR.. 599
19 -17.700[P] COG4559 ABC-type hemin transport system, ATPase component  ali follow..  25  11.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TDLSYSVAGRELLSKLKFHLQSGEMLAVLGRNGAGKSTLL-----KHLTGELGKSG-------------------VELFGQPLRDIKPAEAAKRRAVLP------------------------------------------QQTPLSFAYEVLDVVLLGRIPHGQRETVQDRAIAAACLERVGLSGYE-------------------------TRDVLTLSGGEQQRVHFARTLAQGVIGERVLLLDEPTASLDLAHQHATLRLARELCREGVGVLAVLHDLNLAQYADRVLML------AEGHVIACDHPAVALTPE............. 234
20 -17.500[U] KOG0057 Mitochondrial Fe/S cluster exporter, ABC superfamily  ali follow..  20  302....................................................................................................................................................................................................................................................................................................................................................................................................................................SLINYETVKYFNNEDYEARKYDQLHENYEDAALQSRKSFALLNFGQSFIFSTALSTAMVLCSQGIMNG--------QMTVGDLVMVNGLLF-------------QLSLPLYFLSDTVQGLVDMKSMFKFLEERSDIGD-KDIDRKLPPLVLKGGSIS------ENVHFSYLPERK--------------------------LDGISFEVPAGKSVAIVGSSGSGKSTILRMIF-----------------RFFDVDS------NVKIDGQDIKEVRLESLRSSIGVVPQDTVLFNDT------------IFHNIHYGNLSATEEE----------------------------------------------VYNAAR----RAAIHDTIMKFPD---KYTAVGERGLMLSGGEKQRVALARAFLKSPA---ILLCDEATSALDSKTEAEIMKTLRSLA-SNRTCIFIAHRLTTAMQCDEILVM------EKGKVVEKGTHEVLLGKSGRYAKLWTQQN.. 675
21 -17.400[E] COG1126 ABC-type polar amino acid transport system, ATPase component  ali follow..  28  17.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LHDINLNITQGEVVVIIGPSGSGKSTLL----------RCINKLEVITRGQLIVDGLDVNSPNIDERQ-----------------------------------------------------LEAGMVFQQFYLFPHLTALENVAFGP----------------TKVRGTSKEEAKK---------QALALLSKVGLE--RAHHYPAELSGGQQQRVAIARALAVKPK---LMLFDEPTSALDPELRHEVLTVMKDLAEEGMTMVIVTHEVGFAQVASRLIFI------DKGRIAEDGDPDSLISNPPS-LREFLQHV.. 239
22 -17.300[R] KOG0927 Predicted transporter (ABC superfamily)  ali follow..  15  112........................................................................................................................................................................................................................................................................................................................................................................................................KSSLLAVLGGREVPVPPHIDIFHLTREIPASSKSALQCVMEVDEERIKLEKLAELAMSEEDDAQEQLIDIYERLRILHGLGFDKAMQQKQAKDFSGGWRMRIALARALFVK----LLLLDEPTNHL---DLDACVWLEEELKTYKRILVLISHSQDFLNGCTNIIHLTGKR--TGNYEAFVRTRMELLENQMKQYNWEQDQISHMKNYIARFGHGSAKLARQAQSKEKTLAKM------------------------------VAQGLTEKVSDDKVLNFYFPSCGKVPPPVIMVQNVNFRYNDETPW------------IYKNLEFGIDLDTRLALVGPNGAG--------------KSTLLKLLYGDLVPTSGMIRKNSHLRIARYHQHLHELLDLDLEYMMRAFPDVKEKEEMRKIIGRYGLTGRQQVCPIRQLSDGQRCRVVFAWLAWQVPH---LLLLDEPTNHL---DMETIDALADAINDFDGGMVLVSHDFRLIQVAEEIWVC..................................... 576
23 -17.300[O] COG4133 ABC-type transport system involved in cytochrome c biogenesis, ATPase component  ali follow..  26  17.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FSGLSFTLNAGEWVQITGSNGAGKTTLL-----------------------RLLTGLSRPD--------------------------------------------------------------AGEVLWQGQPLHQV------------DSYHQNLLWIGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLA--FEDIPVNQLSAGQQRRVALARLWLTR---ATLWILDEPFTAIDVNGVDRLTQRMAQHTEQGGIVILTTHQLNVAESKIRRISLT.................................... 200
24 -17.200[U] KOG0058 Peptide exporter, ABC superfamily  ali follow..  16  266....................................................................................................................................................................................................................................................................................................................................................................................FRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTKYYKRLSKEVQNAL-ASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQV---------LQNVSFSLSPGKVTALVGPSGSGKSSCV----------------NILENFYPLEGG------RVLLDGKPISAYDHKYLHRVISLVSQEPVLFARS------------ITDNISYGLPTVPFEMVVEAAQK----------------------------------------ANAHGFIMELQD-------------GYTETGEKGAQLSGGQKQRVAMARALVRNPP---VLILDEATSALDAESEYLIQQAIHGNL-QKHTVLIIAHRLSTVEHAHLIVVL------DKGRVVQQGTHQQLLAQGGLYA......... 735
25 -17.000[CO] COG4987 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components  ali follow..  16  95.......................................................................................................................................................................................................................................................................................................................................................................................................LRIYTFSKLLPLSPAGLARYRQGELLNRVVADVDTLDHLYLRVISPLVGAFVVIMVVTIGLSFLDFTLAFTLGGIMLLTLFLMPPLFYRAGKSTGQNLTHLRGQYRQQLTAWLQGQIFGASDRYRTQLENTEIQWLEAQRRQSELTALSQAI----LLIGALAVILMLWMASGGVGGNAQPGALIALFVFCALAAFEDLTDQKPEVTFPDTQTRVADRVSLTLRDVQQQALKGISLQVNAGEHIAILGRTGCGKSTLLQQLT----------------------RAWDPQQGEILLNDSPIASLNEAALRQTISVVPQRVHLFS------------ATLRDNLLLASPGS-----------------------------SDEALSEILRRVGLEKL------------------------LEDAGLN-SWLGEGGRQLSGGELRRLAIARALLHDAP---LVLLDEPTEGLDATTESQILELLAEMM-REKTVLMVTHRLRGLSRFQQIIVM------DNGQIIEQGTHAELLARQGRYYQFK...... 570
26 -17.000[P] COG1121 ABC-type Mn/Zn transport systems, ATPase component  ali follow..  20  9.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ENLTVYQGNYLAIRDVSFNLLPGTDTAIVGPNGAGKSTLVKAIL------------------------IPRRVGQIEIFGRPITK---------------LGNLRHLLGYMPQNFIFDRSFPISVEE----------------------LVGLGWVAEARHQKSSFLSKLRIQSREKSAAIA------------------TALKRTDTYHLR-NQAIGTLSGGQLKRILLAYCLVIPRK---ILVLDEAFAGVDMQGAADFYAMLNELQQEGWTVLQVSHDIDMVRHCDRVLCLN-------QTVVCTGQPEIALSPQ............. 240
27 -16.800[CO] COG4988 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components  ali follow..  18  208....................................................................................................................................................................................................................................................................................................................................................................................................................................RLQALTTIRLFDRTTAETEHMRGASEVFRHRTMDVLRIAFLSSAVLEFFTSISIALTAVYFGFSYIGELNFGYYGASVTLFAGLFVLILA-----------------EFYQPLRDLGTYYHAKQLAVGAAESIVDFLQTEVDTLHSGERHLSDNDDIEII---NDLVVLSPQGKRL-------------------------AGPLSFTLQSGKTTALVGPSGAGKTSLIN------------------------ILGFMPYQGSLTINGIELRELDHAQWRQTISWVGQNPLLLY------------GTIRDNVTLGKHNI-----------------------------ADEQVTQTLQAAYAQEF------------------------VEQQGLD-YPISDRSAGLSVGQAQRLALARAILQNGR---FWLLDEPTASLDARSEQYVMRGLTESI-QQRTALFVTHQLQPLQSVEQILVM------ENGLLVQAGHFEDLSQQSGLFATMLAANQ.. 583
28 -16.600[V] COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain  ali follow..  21  336..................................................................................................................................................................................................................................................................................................................................................................................................................................................SIATLQSIETLKASGLE----SDFFSRWSGYYTKALNSQQELGITNQTFSVLP----TLLSALSAMLLLIVGGFRVMDHLSIGMLIAFQGLMSGFQQPVNNLVNFGTTLQELEGNLIRLDDVLDNPVGEVGGKTSSSSLQALPKLQGY-KNITFGYSRLEAPL------------------------IENFNLSIKPGQRVALVGGSGSGKSTIA---------KLVSGLYQPWTGE-------------IYFDSQPREEISLQLLTNSVAMVEQEILLFGGT------------------------------------------------------RDNLTLWDTTVPDKNLMRACDAAIADVIFSMS-------------GGYAELIEGAANLSGGQRQRLEIARALVNNPS---ILVMDEATSAL---DAETEKIIDQNLRRRGCTCIIVAHRLSTIRDCDQIIVL------ERGKVVQQGTHQELWQVEGAYSRLIRTE... 711
29 -16.300[P] COG4604 ABC-type enterochelin transport system, ATPase component  ali follow..  22  5.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NDVNKKYQQTTVLNEINERIPSGGITSIIGPNGAGKSTLL---------SIMSRLLAADSGN-------------VLFNGLDVAKTSGDKLATILSVLRQENHFTSRLTVSDLVGF--GRY------------------------------PYSRGRLNKNDRQHIDAAMEFLNLMPLKDRYLDE----------------------------------LSGGQRQRAYVAMVLCQDTS---YILLDEPLNNLDMKHCVAMMKQLRRAAELHKTIILVIHDINASAYSDHIIAM------KNGEVIYRGAPAEIMQPS............. 227
30 -16.300[P] KOG0056 Heavy metal exporter HMT1, ABC superfamily  ali follow..  21  441....................................................................................................................................................................................................................................................................................................................................................................................................................................SLLNFETVKYYGAEHYEVDCYREAILKYQKEEFLSMLTLNMLNTAQNIILCLGLLAGSLLCVYLVVHHQTL-------TVGDFVLFSTYLM-------------ELYMPLNWFGTYYRAI------QKNFVDMENMFDL--------------KEEEEIVDAPGCSPLLTAGGG--IEFSNVTFGYSPEKIV---------LRNVSFTVPAGKTVAIVGPSGAGKSTIMRLLF-----------------RFYDVQT------AILIDGQNIKLVQQQSLRKAIGVVPQDTVLFNNT------------IFYNIEYAKLGASDEA----------------------------------------------VYEAAR----AADIHERILGFPE---KYTKVGERGLRLSGGEKQRVAIARTLLKAPI---IVLLDEATSALDTHTERNIQAALARVC-ANRTTIIVAHRLSTIIHADEILVL------QQGSIAERGRHEELVLREDGIYADMWQQQLK 814
31 -16.300[RK] KOG2355 Predicted ABC-type transport, ATPase component/CCR4 associated factor  ali follow..  17  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAEKDATASGDDAIRVSGMQFA-FFDFNLDLPAGSRCLLVGANGSGKTTLL---------KILAGKHMVGGKNVVQVLSRSAFHDTQLVCSGDLSYLG-------------------------------------------------GSWSKTVGSAGEVPL-----------QGDFSAEHMIFGVEGTDPVRREKLIDLLD-------------------INLQWRMHKVSDGQKRRVQICMGLLHPFK---VLLLDEVTVDLDVVARMDLLEFFKEECQRGATIVYATHIFDGLETATHLAYI------QDGELNRLSKMTDIEELKTS........... 242
32 -16.300[P] COG4778 ABC-type phosphonate transport system, ATPase component  ali follow..  21  24.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LNRASLTVNAGECVVLHGHSGSGKSTL--------------------------------LRSLYANYLPDEGQIQIKHGDEWVDLVTAPARKVVEIRKTTV-----------------------GWVSQFLRVIPRI---------SALEVVMQPLLDTGVPREA-----------------CAAKAARLLTRLNVPERLWHLAPSTFSGGEQQRVNIARGFIVDYP---ILLLDEPTASLDAKNSAAVVELIREAKTRGAAIVGIFHDEAVRDVADRLHPM..................................... 222
33 -16.200[PH] COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components  ali follow..  25  9.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGKSTLL---------RSLARLMKPRGGS-------------VLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ--GRYPYQNWLKQ-----------------------------SKEDEEAVERALKATKLEDMADRAVDS----------------------------------LSGGQRQRAWIAMTLAQETD---IILLDEPTTYLDMTHQIEILDLLFELEKEDRTIVMVLHDLNACRYAHHLVAI------KDKRIYAEGRPEEVITCD............. 233
34 -16.200[R] COG4619 ABC-type uncharacterized transport system, ATPase component  ali follow..  25  23.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LNNINFSLRAGEFKLITGPSGCGKSTLLK------------------------VASLISPT--------------------------------------------------------------SGTLLFEGEDVSTL-------KPEIYRQQVSYCAQTPTLFGDTVYDNLIFPWQIRNRQPDPAIFLDFLERFALPDSILTKNIAELSGGEKQRISLIRNLQFMPK---VLLLDEITSALDESNKHNVNEMIHRYVEQNIAVLWVTHDKDEINHADKVITL------QPHAGEMQEARYELA................ 225
35 -15.800[V] COG1132 ABC-type multidrug transport system, ATPase and permease components  ali follow..  18  185..........................................................................................................................................................................................................................................................................................................................................................................................................................................VSKRFRNISKNMQNTMGEVTTSAEQMLKGHKEVLIFGGQTERFDAVSNRMRQQGMKLVSASSISDPIIQLIASFALALVSFPSVMETLTAGTITVVFSAMIALMRPLKSLTNVNTQFQRGMAACQTLFSILDMEQEKDEGKLEV-AKGDIE------RHVTFYYPGKDTPA------------------------LNDINIHLEAGKTVALVGRSGSGKSTIAN------------------------TRFYDVSEGSILLDGHDLRDYRLGALRNQVALVSQNVHLFN------------DTVANNIAYARNEQYSRAEIEEA---------------------------------------ARMAYAMDFINKMEH-------------GLTVIGENGIMLSGGQRQRIAIARALLRNCP---ILILDEATSALDTESERAIQAALDELQ-KNRTSLVIAHRLSTIEKADEIVVI------EDGRIVERGVHAELLVQQGVYAQLN...... 576
36 -15.500[Q] COG4181 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component  ali follow..  28  26.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LTGVELVVKRGETIALIGESGSGKSTLLA----------ILAGLDDGSSGEVSLVGKP----LHQMDEEARAQLRAQHVGFVFQSFMLIPTLNA---------------------------------------LENVELP---------------ALLRGENSGQ-----------------SKAGAKALLEQLGLGK-RLDHLPAQLSGGEQQRVALARAFNGRPD---VLFADEPTGNLDRQTGDKIADLLFSLREHGTTLILVTHDPALAARCDRRLRL..................................... 219
37 -15.300[E] COG0411 ABC-type branched-chain amino acid transport systems, ATPase component  ali follow..  24  17.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LQDVNIEVPQGTIFGLIGPNGAGKTTVFN----------------LITGLLEPTGGTLTFGGTSLVGKKPHQITQMGIARTFQNI-----RIFKEMTLLEN-------------------------VVVGMHRHLDYGAPGLLLSLPGYRAAERRARDRALELLSWVKLD-----------------------------KAGDIADNLSYGDQRKLELARALA---TEPKLLLLDEPVAGMNTGEKVDLMAEIENIRARGYTIFMIEHDMRFVGLCERIAVLN-------GRIIAEGPPEAIRNNPEAYLGR....... 249
38 -15.300[R] COG1137 ABC-type (unclassified) transport system, ATPase component  ali follow..  25  19.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VSDVSLTVNSNEIVGLLGPNGAGKTT-----------------------------------------------------------------------------------TFYMVVGLVRQDQGKIVIDGE-----------DISLLPMHNRAQRGIGYLPQEASIFRRLTVYENLMALTPQQRREKADELIEEFNISHIR-DNLGQALSGGERRRVEIARALA---ANPKFILLDEPFAGVDPISVSDIKKIITDLRNRGLGVLITDHNVETLDVCERAYIV------GAGKIIATGTPEQVMNDERVYLGEQFK.... 240
39 -15.000[D] COG2884 Predicted ATPase involved in cell division  ali follow..  26  19.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LDNVNVKIDKGEFVFLIGPSGSGKSTFM----------RLLLGAETPTSGDVRVSKFH----VNKLPGRHIPRLRQV-----------------------------------------------GCVFQDFRLLQQKTV---------------------ENVAFALEVIGRRSDAINQVVPDV------LETVGLS--KANRLPDELSGGEQQRVAIARAFVNRPL---VLLADEPTGNLDPDTSKDIMDLLERINRTGTTVLMATHDHHIVDSRQRVVEL------SLGRLVRDEW..................... 221
40 -14.900[R] COG2401 ABC-type ATPase fused to a predicted acetyltransferase domain  ali follow..  16  21....................................................................................................................................................................................................................................................................................................VELDNGLTLYMSGIAAWLFEGDVVEVVIKNEPKEIYGRKILFFADYESRNLELPRYSFGKEVYRYRIR---AREAVYEKDFERIAELEQYHYASQKSK---------VALWKCYDC-GNLIEANTKPVCECGSRNVHIVEIKGSTPASRFLIFELVERQRKLDGKIVENIRERVRFSLKVARHRLWEEASEEAMKKCNSAASRIARVVGLGILAVRTAVEERRV--EMRMRKHLVETIAQMARFGKPVLYKPLSEEAERYIRKFLEEDEVARGHGGKLCVSRYGSVKPLEKRNVSKLFASTLDLEKVSDEVRTVLESFGVRQRVVERYVLRDVNLEIKPGEIVAVVGASGSGKTTFLR------------------------IVGEA-----------------------------------------------------------------------------------LKLDDDVYKPSSGMVEVVVDSIAAMIPSELEPQITEKSILGDIHLAVEVLNRAGIS-VLYRARFNELSTGQKERFKLAACLAKKPS---LMLVDEFAAHLDEMTAVRVARKISELAEAKITLIAVTHRKEVINSPDRILYV------GYGGVTES....................... 619
41 -14.800[R] COG0488 ATPase components of ABC transporters with duplicated ATPase domains  ali follow..  19  125.............................................................................................................................................................................................................................................................................................................................................................................................................................................................EQANLEAIIQAHDGHNLDNQLERAAD-ALRLPDWDAKIEHLSGGERRRVALCRLLLEK----MLLLDEPTNHL---DAESVAWLERFLHDYEGTVVAITHDRYFLNVAGWILELDRGEGNYSSWLEQKEKRLEQEQATENARQKSIAKELE-QNPKGRQAKSKARMARFDELNSGEIDDLSFSIPKGAIVGIIGANGAGKSTL-----------------------------------------------------------------------------------FRMLSGQEQPDSGSVTMGETVVL--------------ASVDQFRDSMDDKKTVWE----EVSNGQDILTIGNFEIPSRAYVGRFNFKGVDQQKRVGELSGGERGRLHLAKLLQRGGN---VLLLDEPTNDL---DVETLRALENAILEFPGCAMVISHDRWFLRIATHILDYGDEG................................. 519
42 -14.700[I] KOG0064 Peroxisomal long-chain acyl-CoA transporter, ABC superfamily  ali follow..  15  322..........................................................................................................................................................................................................................................................................................................................................................................................................................SRIITNAEEIAFYGGHKVEMQQLR-----QAYNRLVNQMTTIFNQKLWFIMLEQFFMKYVWSGTGMIMVSLPGSDVGLGTVPNTAISESRVSERTQYLTTARNLLISAAD---ERLMSSYKEIVSLAGYTFRVAGMMDVFEETALGVYCKTSVMESNQSNGIIEFRNGKPIAKGRIIYSDDPKNMSISLRAVPVVTPNCDIV---------VPKLTLCIEPGVHLLITGPNGCGKSSLF---------RILSGLWPIYAGELHIPRPVKDVPCMFYIPQRP-----------------------------------------------------IGSLCDQI----------------IYPDTREDMKRKHITENELRSILKMVSLEHIAQ----------------SFDVVRDWKDILSGGEKQRMAIARLFYHRPR---YALLDECTSAVSIDVESSIYEIAKGM---GITLLTITHRPTLWKYHTHILEFDGLGN---WQFRKMNSDEEQKGQFLS........... 730
43 -14.100[R] COG1101 ABC-type uncharacterized transport system, ATPase component  ali follow..  22  22.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LRGVSLEVPEHQFLTVIGSNGAGKSTLL----------GAVTGETPIVGGQVLIDEIDVTKQSVDQRANLCARDPLAGTCGALTIEENM-----------------------------------------------------ALAYMRGKKRGWSLALSNQRRKLFQER---------------------ISILGLGL-RLGDNIGLLSGGQRQAVSLVMATLSESK---LLLLDEHTAALDPRMAAFIIDLTKKIVEFNLTVMMVTHSMDALACGDRTVML------HQGQIVLDVTGEQRANMGVP........... 242
44 -14.100[E] COG0410 ABC-type branched-chain amino acid transport systems, ATPase component  ali follow..  25  5.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DKVSTYYGKIQALHDVSVEVKKGEIVTLIGANGAGKSTLLM---------------------------------------------------TLCGSPQA----------------ASGSIRYE--GEELVGLPSSTIMRKSIAVVPE---------GRRV--------FSRLTVEENLAM-FTDKDDYQVQMDKVLELFPRLKE------RYEQRAGTMSGGEQQMLAIGRALMSKPK---LLLLDEPSLGLAPIIIQQIFEIIEQLRREGVTVFLVEQNANALKLADYVLENG--------RIVMHDTGAALLKVRDAYLG........ 232
45 -14.000[Q] KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein)  ali follow..  23  103......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RPKTKTLLNNISGETRDGEIMAVLGASGSGKSTLIDALANRIAKGSLKGT--------------------VKLNGETLQSRMLKVISAYVMQDD---------------------------------------------LFPMLTV-----------EETLMFAAEFRLPRSLPKSKKKLRVQALIDQLGIRNAAKTI--IGDEGHR-------ISGGERRRVSIGIDI---IHDPILLFLDEPTSGLDSTSAFMVVKVLKRIAQSGSIVIMSIHQ-RVLGLLDRLIFL------SRGHTVYSGSPASLPRFENENRTEFALDLIR 347
46 -13.600[IR] KOG0060 Long-chain acyl-CoA transporter, ABC superfamily (involved in peroxisome organization and biogenesis)  ali follow..  15  185.....................................................................................................................................................................................................................................................................................................IQNADQLLTQDVDRFCDGIVELYSNLSKPILDVFLYLFRLGTSLGFSSPSILFSYLLFTGVGLTYLRRPIGRLTVEEQALEG-----EYRYVNSRLIMNSEEIAFY---------QGNQSEKETIMSTFASLVQHLRKIILFRFSIGFVDNI------------VAKYLATVVGWYAVGSSFFDKQHKPFIGMSRNQYNSGRMMYKMAEALGRLALAGRD----------TRLSGFTSRVDTLLNVLDDVNSGNYKRTMVG----------------EKEESSALIKSELVAGSGNLRVQDNVIRFDNVPLVTPNGDVL---------IERLNFEVPSGTNVLVCGPNGCGKSSLFRVLLWPLFGGTLT---------------KPAKGKLFYVPQRP------------------------------------------------------GTLRDQIIYPDRP-------------LDMIRKGVSDSDLEQMLENV----------------QLTHILEREGGWSAVQDWMDVLSGGEKQRIAMARLFYHKPQ---FAILDECTSAV---SVDVEGAMYRLCREKNITLFTVSHRKSLWKYHEYSLYM------DGRGSYRFEQIDDQSDQFGS........... 661
47 -13.300[CP] COG4555 ABC-type Na+ transport system, ATPase component  ali follow..  20  21.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VRDVSLTIEKGEVVGILGENGAGKTTML----------RMIASLLEPSQGVITVDGFDTVKQPAEV-KQRIGVLFGGETGLYD------------------------------------------------------------------------------------RMTAKENLQYFGRLYGLNRH-DLSKRFGMR--YMNRRVGGFSKGMRQKVAIARALIHDPD---IILFDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVALCDSVIMI------HSGEVIYRGALESLYESERS........... 230
48 -13.200[P] COG4107 ABC-type phosphonate transport system, ATPase component  ali follow..  21  9.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HELSKSYGGIKACDRISFDLYPGQVLGIVGESGSGKSTLLGAIADHIAVDHGNVTYISRSGEDLEIFQLAKRRLLMRTEWGFVQQNPRDGLRMRVSA--------------------------------------------------------------------------GANIGERL-----LDIGVRHYGNIRDEAAHWLREVEIDPTRIDDLPAQFSGGMQQRLQLARVLVTRPR---LILMDEPTGGLDVSVQARLLDLLRSLVNFHLSVIIVTHDIGVVRLAHRLLVM--------GQVVESGLTDQVLDDPQPYTQLLVSAA.. 254
49 -13.200[QP] COG4615 ABC-type siderophore export system, fused ATPase and permease components  ali follow..  14  55.............................................................................................................................................................................................................................................................................................................................................................................................................................................LGLLLLLMAVTLGSQLALTTLGHHFVYRLRSEFIKRILDTHVERIEQLGSASLLAGLTSDVRNITIAFVRLPELVQGIILTIGSAAYLWMLSGKMLLVTAIWMAITIWGGFVLVARVYKHMATL-----------------------RETEDKLYTDFQTVLEGRKELTLNRERAEYVFNNLYITFHLSAVNWSNIMMLGAIGLVFWMANSLGWADTNVAATYSLTLLRTPLLSAVGALPTLLTAQVAFNKLNKFALAPFKAEFPRPQAFPNWQTLELRNVTFAYQDNAFS-------GPINLTIKRGELLFLIGNGSGKSTLMLLTGLY---QPQSG--------EILLDGKPVSGEFSAVFTDVWLFDQLLQLVEKWLAQLKMAHKLELSNGRVNLKLSKGQKKRVALLLALAEE---RDIILLDEWAADQDPHFRREFYQVLLPLMEMGKTIFAISHDDHYFIHADRLLEM------RNGQLSELTGEERDAASRDAV.......... 543
50 -13.000[Q] COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component  ali follow..  22  22.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................WEDVTLDIPAGEVSVLLGPSGTGKSVFL-----------------------KSLIGLL----------------------------------------------RPERGSILIDGTDIIECSAKELYEIRTLF------------GVLFQDGAL---FGSMNLYDNTAFPLREHTKKKESEIR-DIVMEKLQLVGLGGDEKKFPG-EISGGMRKRAGLARALV---LDPQIILCDEPDSGLDPVRTAYLSQLIMDINAQDATILIVTHNVNIARTPDNMGML------FRKHLVMFGPREVLLTSDEPVVRQFLNGRRI 247
51 -12.900[R] COG4178 ABC-type uncharacterized transport system, permease and ATPase components  ali follow..  15  136.......................................................................................................................................................................................................................................................................................................................................................................................ARVMADIYLTQRFIIAWRMWLTNHLTTDWLDQRAYYREQFIDNTIDNPDQRIQQDIDIFTAGAGGTPNGP-SNGTGSTLLFGAVESVISVISFMFWIVIVYVLLATIITFWIGRPLIGLKLNAAFRYALVRLRDAAEAVAFRGEEAERKQLEQRFTPIIDVSQTIVPLPWILQAPRLFAGKINLGDVGQTATAFGNIHDSLSFFRNNYAAFAAFRAAIIRLHGLVVANARSRELPHVTAKSTNDGTIDPLDLQLNCGSSLVITGRSGVGKTTM-------------------------------------------------------------LRSLAE----------------WPYASGTLSRPDGKN----ETMFLSLPYVPLGNLRG--------VVCY-PNAPADIPEDTVRDTLT--VALNPLCDRLDEERD-----------AKILSPGEQQRIAFARILLTKPK---AIFLDESTSALDEGLEFALYQMLRSEL-PDCIIVSVSHRRAVELLHAQQLEL-----LGGGQWRLGPVEKEPLHV.............. 638
52 -12.600[R] COG3910 Predicted ATPase  ali follow..  19  26.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MRHLERLEFKTPITFFAGNNGSGKSTL-----------------------------LEGLAAGMTAYAIGNHGDVKGDLYLQHAETVAKAFYFARKKYPKIRMFLRAEDVLGY-------------------------------------------------IRRQNENALDDFRWEREKALKKGEDFPEETPEIFRGIVRNNSLDRRSHGE-GFLDIMHRRLH---GAGLYFLDEPESPLSPQKQLELAAIIRQAADSGGQLIIATHSPVLLAIPEATIYYFDEDG------ITERLYDELENIA--FLRRFLDR... 251
53 -12.600[H] COG3840 ABC-type thiamine transport system, ATPase component  ali follow..  23  7.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ITWLYHHLPMRFSLTVERGEQVAILGPSGAGKSTLLN------------------------IAGFLTPAS-LTIDGVDHTTTPPSR-------------------------------------------RPVSMLFQENNLFSHLTVAQNIGLGLNPG----------LKLNAVQQEKMHAIARQMGIDNLMARL-----------------PGELSGGQRQRVALARCLVREQP---ILLLDEPFSALDPALRQEMLTLVSTSCQQKMTLLMVSHSVDAARIATRSVVV------ADGRIAWQGMTNELLSGKASASA........ 226
54 -12.500[P] COG4148 ABC-type molybdate transport system, ATPase component  ali follow..  26  4...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LNFSQTLGNHCLTINETLPANGITAIFGVSGAGKTSLIN------------------------ISGLTRPQ--------------------------------------------------------------KGRIVLNGRVLNDAEKGICLTPEKR------RVGYVFQDARLFPHYKVRGNLRYGMAKSMVDQFDKLVALLGIEPL-LDRLPGSLSGGEKQRVAIGRALLTAPE---LLLLDEPLASLDIPRKRELLPYLQRLTRENIPMLYVSHSLEILHLADRVMVL------ENGQVKAFGALEEVWGSSVM........... 222
55 -12.400[P] COG1117 ABC-type phosphate transport system, ATPase component  ali follow..  19  28.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EDLHVYYGDNHAIKGVDLTFPENKVTALIGPSGCGKSTYLRAL-----------------NRMNDEIDGCRMEGQILYD----GININRKEVDLYNVRKEIGMVFQ----------KPNPFTKSI-----------------------------------YENVAFGLKRHGMKNKKEIMERVEKSLRRAALWDEVKDDLG-------------KSALSLSGGQQQRLCIARAVAMQPK---VLLLDEPASALDPISTSKIEDLINELKNK--TIIIVTHNMQAARVSDYTSFF--------GEVVEFSGTSELFTNPQEISGNF...... 270
56 -11.900[V] COG4170 ABC-type antimicrobial peptide transport system, ATPase component  ali follow..  20  23.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VDRISMTLTEGEVRGLVGESGSGKSLIAKAICVSKDNWRITADRFRFNDIDLLQLTPRQRRKVIGHNISMIFQEPQSCLDPSESI--------------------------------------------------------------------------GLQLIQAIPGWTYKGRWWQRFHWRKRRAIELLHRVGIK--IMHSYPYELTEGECQKVMIAIALANQPR---LLIADEPTNAMEPTTQAQIFRLLARLNQNNTTILLISHDLQMMKWATRVNVL-------CGQTVESAVCEDLLSTPHPYTQALIRAM.. 262
57 -11.900[V] COG1136 ABC-type antimicrobial peptide transport system, ATPase component  ali follow..  25  23.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LKQISFSIEEGEFTAVMGPSGSGKTTLLN---------------------------------ISTIDRPDSGD----------------------------------------------LINGENPHRLKRTKL------------AHFRRKQLGFVFQDFNLLDTLNIMLPLTLEKEAPSVMEEKLHGIAAKLGIENL-LNKRTFEVSGGQRQRAAIARAV----HKPSLILADEPTGNLDSKATKDVMETLQSLRDDHVTALMVTHDPVSASYCRRVIFI..................................... 216
58 -11.800[R] COG4152 ABC-type uncharacterized transport system, ATPase component  ali follow..  12  20.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LDLDIPEQQMFGLLGANTFRMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGMEKR-TWLERFNIT--YENKKVEELAKGNQQKIQFISAVLHKPE---LLILDEPFSGLDPVNVELLKEAVISLKNSGVSILFSSHRMEHVELCENLCIL------QKGKPVVQGKLKEIKR............... 218
59 -11.200[V] COG1131 ABC-type multidrug transport system, ATPase component  ali follow..  26  8................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SGVSKTYATGFTALKEVNLDIQRGEIFALLGPNGAGKTTLI-----------------------------------------------------------------------------------SIVCGIVNRSTGTVTV--------------DIGKDYRAARSLIGLVPQELTIDAFESVTVNYSRGLFGKPPNHGFVEKVLRDLSLW--KKDAKAITLSGGMKRRLMIAKALSHEPR---ILFLDEPTAGVDVELRQDMWEMVRRLREDGVTIILTTHYIE---EAEAMAD-------NRGEIILVENKAELMH............... 223
60 -10.800[R] COG4136 ABC-type uncharacterized transport system, ATPase component  ali follow..  19  17.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LTNVNFTVDKGDIVTLMGPSGCGKSTLFSWMI--------------------------------------------------------------------------------------------GALAEQFSCTGELWLNEQRIDILPTAQRQIGILFQDALLFD--QFSVGQNLLLALPATLKGNARRNAVNDALERSGLEQDPATLSGGQRARVALLRALLAQPK---ALLLDEPFSRLDVALRDNFRQWVFSEVRAAIPVVQVTHDLQDVPADSSVLDMAQWS................................. 210
61 -10.800[EP] COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component  ali follow..  21  24.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VNDLNFSLKQGETLGIVGESGSGKSQTVFAIMGLLAKNGKITGSAKFEGKEILNLPERELNKVRAEQIAMIFQDPMTSLNPYMKV--------------------------------------------------------------------------SDQLMEVLMLHKG-----MGKAEAFEESVRMLEAVKIP--RITMYPHEFSGGMRQRVMIAMALLCRPK---LLIADEPTTALDVTVQAQIMELLNELKRENTAIIMITHDLGVVGSCDKVLVM-------AGRTMEYGSVNDIFYNPSPYAEGLLSAI.. 257
62 -10.800[R] COG4674 Uncharacterized ABC-type transport system, ATPase component  ali follow..  23  21.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LNHLTFSMNPGELRVIIGPNGAGKTTFLD---------------------------------------------------VITGKVQP----------------TEGRVLFQ----------GKDIRKIPEYRIARLGV------GRKFQTPRV---YLNLTVAENLDLAVNRKKSVWGTLAEQRSVGGLLETIGLT--KAHLAAALLSHGEKQRLEIGMLVAQSPT---LLLVDEPVAGLTDEETENVGDLLLALAE-SHSIIVIEHDMEFVRQARKVTVLH-------GSVLCEGNMDQIQNDPEVYLGE....... 245
63 -10.800[P] COG1135 ABC-type metal ion transport system, ATPase component  ali follow..  27  8................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NKVFYQGDKQIHALKDINLFIPQGTIFGVIGSSGAGKSTLI----------RCVNMLEKPTSGQVIVDGVD----LTTLSNPQL-CAARRNIGM---IFQHFNLLSSRT------------------------------------VFENVALPLELAGQSQQHIE--------TKVTELLAL------------------------VGLS--KRESYPANLSGGQKQRVAIARALA---SDPKVLLCDEATSALDPATTQSILELLKEIRQLNLTILLITHEMDVVKSICHEVAI------GGGELVEKGTVGDIFAHPKTLAHQFIRSTLD 246
64 -10.700[P] COG1118 ABC-type sulfate/molybdate transport systems, ATPase component  ali follow..  27  18.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LNDISLDIPSGQMVALLGPSGSGKTTLL-----------------------RIIAGLEHQTS-IRFHGTDVSRLHARD-------------------------------------------RKVGFVFQHYALFRHMTVFDNIAFG-------LTVLPRRERPNA----------------AAIKAKVTKLLEVQLAHLA-DRYPAQLSGGQKQRVALARALAVEPQ---ILLLDEPFGALDAQVRKELRRWLRQLHEEKFTSVFVTHD-EATEVADRVVVM------SQGNIEQADAPDQVWREPATFVLEFMGEV.. 240
65 -10.600[S] COG4694 Uncharacterized protein conserved in bacteria  ali follow..  10  3........VCINRLKQFGI--KFGRYNLVYGWNGTGKSTLSNLFSCFELRSMVPRFSAGQFSVALEDGSTITEATLHSCQLNIHVNQRFVHEN-KEKIDDLQKLEKLKGELQSKRKARDEKQGEVKKQREALDKFLTNAAKKMKLGLQAIDTSDSYYLNYDRRKLSNFIQSNGEAIIKADSILSDDKVIDLTNAAKPDQLPSIFKKASGRIRDLIGTTAVNQAIQRLTDNPDIREWVQTGLEIHKNHESQSCEFCGSTFTQLRAEALAAHFSKEFTDFQRRLQNAATWIESQGAPANQLPAATEFYKELSAEADKLQKDYATAAEKIDKQMDGWREALKAKITDP----KTDIQISDVVEDDVKNFNEILKSIVALVGKHNNKTSNFKSSKSKVALELHFAAAEVQEFDYAGSEKKCNDLESEAKNDHK----EIEKISQEVGAIEALLSNETVGAKEFNDILHRFIGRSELCLSF-GMGEHDGNLSEGEKTAIAFVYFITNNIKDTIVVVDDPVSSFDSNHLFHAYSFLRTQCTEAKQLFVLTHNFTYFKLVRDWFT.............................................................................................................................................................................................................................................................................................................................................................................................. 597
66 -10.600[V] COG4167 ABC-type antimicrobial peptide transport system, ATPase component  ali follow..  22  30.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VKPLSFTLREGQTLAIIGENGSGKSTLAKMLA------------------------IEPTSGELLIDDHPLHFGDYSFRSQ----------------------------------------------RIRMIF-----------------QDPSTSLNPRQRISQILDFPL-RLNTDLEPEQRRKQIIETMRMVGLLPDHVSYYPHMLAPGQKQRLGLARALILRPK---VIIADEALASLDMSMRSQLINLMLELQEKGISYIYVTQHIGMMKISDQVLVM--------GEVVERGSTADVLASPHELTKRLIAGH.. 254
67 -10.500[P] COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component  ali follow..  21  31......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DGGRFDAVAESNLAVAENEFVAIVGPTGCGKSTLL-----------------------------------------------------------------------------------NAVAGLLTPASGTVEI-----------------SGQRLQGLNRKAGYLFQQDALMPWKTVLENVAIGLEIAGTPKA-EWLNKVGLGTFGDRYPH-MLSGGQRKRVGLAQVLIRNPK---YLLMDEPFGPLDAQTRVIMGDLLLDLSQDKKAVMFVTHDLEAIALADRVVIMGPRARIMAEYRIPLARPREISEIRLDNQFHEIHREI. 261
68 -10.500[E] COG4175 ABC-type proline/glycine betaine transport system, ATPase component  ali follow..  24  13..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IFGEHPQRAFKYIEKGLSKEQILEKTGLSLGVKDASLAIEEGEIFVIMGLSGSGKSTM-----------------------------VRLLNRLIEPTRGQV------------------------------------------------LIDGVDIAKISDAELREV--------------RRKKIAMVFQSFALMPHMTVLDNTAFGMELAGIAAQLDALRQVGLE---AHAYPDELSGGMRQRVGLARALA---INPDILLMDEAFSALDPLIRTEMQDELVKLQAKQRTIVFISHDLDAMRIGDRIAIM------QNGEVVQVGTPDEILNNPANYVRTFFRGV.. 268
69 -10.400[R] COG4586 ABC-type uncharacterized transport system, ATPase component  ali follow..  19  3............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ENLSKVYPIALKSPGLKGTLQHFWQRRYRQILAVQDISFTIPPGAMVGFLGANGAGKTTTL----------KMLTGLIKPSGGKVRVAGFDPFRRQTAFLRR-----------------------------------------TSLVMGQKQQLIWDLPTLDSLRINGAIY-----------EIPDQVFEQRLGELSEMLDLT-----------------------------ELKQPVRKLSLGQRMKAELLAALLHHPT---VLFLDEPTLGLDVNAQVAVRRFLQEYRRYQATVLLTSHYMDITTLCERVLLI------HQGQLMYDGDLEALVE............... 242
70 -10.100[E] COG1125 ABC-type proline/glycine betaine transport systems, ATPase components  ali follow..  20  22.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VDSVSLTVEKGEICVFLGPSGCGKTTTL----------KMINRIIPPTSGRVLIDGQD----TADLDEVTLRRH--------------------------------------------------GYVIQQIGLFPNMTIEENIMVVPRLLG--WDKARCKEKARELMSMVKLEPKQYLQRYPR-----------------------ELSGGQQQRVGVIRALA---ADAPLLLMDEPFGAVDPINRESIQNEFFEMQRKGMTVIMVSHDIDAIKLGDKVAVF------KSGRLLQYDHPDTLLAHPADFVSAFTGQ... 243
71 -10.100[O] COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component  ali follow..  21  9...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ARIVDDGTEIIRGLNLTVKAGEVAAIMGPNGSGKSTLSYILA--------------------------------------------------------------------------GREDYEVTEGDI-LYNGQSILEMDPAFLAFQYMEIPGVATMEFLKVAMNEQRKARGEEPL------KIPEFLKRVKEAAASLNMDMAMLKRPLNVG-----FSGGEKKRAEI---LQMKLLEPKLCVLDETDSGLDIDALKIVSDGVNALRAPDRAFLVITHYQRLLEVPDSVHVL-------RGQVIKSGDKSLALDLEANGYAGVIGEA.. 250
72 -9.990[P] COG4525 ABC-type taurine transport system, ATPase component  ali follow..  28  17.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LQDVSLQIASGQLVVVLGPSGCGKTTL--------------------------------LNLIAGFMTPSAGV--------------------ITLDNIPVSGPSAER----------------GVVFQNEGLLPWRDVVSNVEFGLQLAG--------------------------MSKEQRRVTALKMLNRVGLAGFEHHFIW-QLSGGMRQRVGIARALAVDPR---LLLLDEPFGALDAFTREQMQELLLTIRDTGKQILLITHDIEAVFLASELLLLSPGPG................................ 207
73 -9.830[EP] COG1124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component  ali follow..  20  6....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LEIRNLSRCFPIHNALGRQTGEVRAVDDVSFYIERGAVYGLAGESGSGKSTIARLIM--GLEKPSCGEIRIDGEMIAAGAHSRAHGKKVQVFQNPGSSNPRRTVGQSVA-------------------------------------------------------------------VPLDAHGFPSL-------------------QRAKRISELLEMVQLPANFAERFPHELSGGQKQRVAIARALAVAPK---LLVLDEPTSALDVSVQAKVIDLLVDLGRRDLTYLFISHDLSLMRFASRVGIL--------GKLVETGKTDEVFYRPHAYTQLLLASV.. 255
74 -9.780[R] COG4637 Predicted ATPase  ali follow..  14  2..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TETKDKQLSRIVLKGFKSIKCDLEISRVNILIGANGAGKSNFIGRMVGQLVEENLQVFVSRQGSPDALLHFGRKTTEHLEFQLYFGNNGYFATLEPTQDNRLMFARESFWWNMSGEHEIGRGHFETKVLTSTRTGIDEYVLSAMQQWRVYHFHDTSESAYIKQPHNDNAYLRPDARNLASFLYLLRNSYPASYQRIKTIRLVAPFFGDFYLRPAPQNKKAYLLSDGTLRFMCLATVFQPEDLQPETILVDEPELGLHPYAITVLASLMR---TASKQVIVSTQSIELLNQAKDVIVVDRSEGS............................... 326
75 -9.610[E] COG3842 ABC-type spermidine/putrescine transport systems, ATPase components  ali follow..  25  20.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VDDLDLAVESGQFVTLLGPSGCGKSTTL-----------------------RMLGGFEQPSS-IYLEGKPITHLPPNR-------------------------------------------RNVNIVFQDYALFPHLNVGRNIAFGLELKG--LSSDAIHKRTMELLALVKLQDFA-------------------------DRMPDQLSGGQRQRVALMRALAPDPN---VLLLDEPLSALDAKLRQQMQIELKTIQRTGKTFIFVTHD-EALTMSDVIVVM------NKGRIEQMGGPNELYSRPRSFVANFI..... 235

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Jaroszewski L, Rychlewski L, Godzik A. Improving the quality of twilight-zone alignments. Protein Sci. 2000 Aug;9(8):1487-96.