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Query: [L] COG0178 Excinuclease ATPase subunit, from COG0516

Results of FFAS03 search in COG0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDKIEVRGARTHNLKNINLTIPRDKLIVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLSLMEKPDVDHIEGLSPAISIEQKSTSHNPRSTVGTITEVYDYLRLLYARVGEPRCPEHQVPLKAQTISQMVDKVLELPEGSKMMLLATIVKERKGEHVKTLENLAAQGFIRARIDGETCDLTDPPKLELHKKHTIEVIVDRFKVRSDLQQRLAESFETALELSGGIVVVAPMEGDGEEQIFSANFACPHCGYSMRELEPRLFSFNNPAGACPTCDGLGVQQYFDPDRVIQDANLSLAQGAIRGWDQKNFYYFQMLTALAEHYDFDVHTPFNKLSKKIQEIILHGSGRTEIEFKYINDRGDIRLKKHPFEGILHNLERRYRDTESNSVREELAKYISNKPCSSCDGTRLKIEARNVFINDTALPTIVELSIADALTFFQELKLEGQRAQIAEKVMKEINDRLQFLVNVGLNYLNLSRSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLQTLTHLRNLGNTVLVVEHDEDAIRMADHVIDIGPGAGVHGGMVVAEGNVEEIIANPNSLTGQYLSGVKKIAVPEQRTPKDAKKTVELKGAVGNNLKNVDLSIPVGLFTCVTGVSGSGKSTLINDTFFKIAHTALNGATTATPAPYRSIQGLEHFDKVIDIDQSPIGRTPRSNPATYTGIFTPIRELFAGTQESRSRGYQPGRFSFNVRGGRCEACQGDGVIKVEMHFLPDVYVPCDVCKGKRYNRETLEVRYKGKTIDEVLDMTVEDAREFFDPVPVIARKLQTLMDVGLSYIRLGQSATTLSGGEAQRVKLARELSKRDTGKTLYILDEPTTGLHFHDIQQLLSVLHRLRDHGNTVVVIEHNLDVIKTADWIIDLGPEGGQGGGLIIAEGTPEDVAQIEASHTARFLKPLLNLast
1 -285.000[L] COG0178 Excinuclease ATPase subunit  ali  100  1MDKIEVRGARTHNLKNINLTIPRDKLIVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLSLMEKPDVDHIEGLSPAISIEQKSTSHNPRSTVGTITEVYDYLRLLYARVGEPRCPEHQVPLKAQTISQMVDKVLELPEGSKMMLLATIVKERKGEHVKTLENLAAQGFIRARIDGETCDLTDPPKLELHKKHTIEVIVDRFKVRSDLQQRLAESFETALELSGGIVVVAPMEGDGEEQIFSANFACPHCGYSMRELEPRLFSFNNPAGACPTCDGLGVQQYFDPDRVIQDANLSLAQGAIRGWDQKNFYYFQMLTALAEHYDFDVHTPFNKLSKKIQEIILHGSGRTEIEFKYINDRGDIRLKKHPFEGILHNLERRYRDTESNSVREELAKYISNKPCSSCDGTRLKIEARNVFINDTALPTIVELSIADALTFFQELKLEGQRAQIAEKVMKEINDRLQFLVNVGLNYLNLSRSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLQTLTHLRNLGNTVLVVEHDEDAIRMADHVIDIGPGAGVHGGMVVAEGNVEEIIANPNSLTGQYLSGVKKIAVPEQRTPKDAKKTVELKGAVGNNLKNVDLSIPVGLFTCVTGVSGSGKSTLINDTFFKIAHTALNGATTATPAPYRSIQGLEHFDKVIDIDQSPIGRTPRSNPATYTGIFTPIRELFAGTQESRSRGYQPGRFSFNVRGGRCEACQGDGVIKVEMHFLPDVYVPCDVCKGKRYNRETLEVRYKGKTIDEVLDMTVEDAREFFDPVPVIARKLQTLMDVGLSYIRLGQSATTLSGGEAQRVKLARELSKRDTGKTLYILDEPTTGLHFHDIQQLLSVLHRLRDHGNTVVVIEHNLDVIKTADWIIDLGPEGGQGGGLIIAEGTPEDVAQIEASHTARFLKPLLN 940
2 -24.600[A] KOG0063 RNAse L inhibitor, ABC superfamily  ali follow..  20  144.........................................................................................................................................................................................................................................................................................................................................................................................................................LTHFRGSELQSYFIRVVEENLKTAIKPQHVDYIKEVVRGNLGKMLEKLDERGLMEEI--CADMELNQV-LEREARQVSGGELQRFAIAAVFVKK----IYMFDEPSSYLDVRQRLKAAQVIRSLLRHDSYVIVVEHDLSVLYLSDFVCCLYGKPGAYGVVTLPFSVREGIFIPTENLRFRDESLTFRVSETTQENDGEVKSYARYKYPNDFKLEVMEGEFTDSQIIVMLGENGTGKTTFI---------------------------------RMLA-----------------------------------------------------------GAFPRE--------------EGVQSEIPEFNVSYKPQGNDSKRECTVRQLLKIRDACAHPQFMSDVIRPLQIEQL-MDQVVKTLSGGEKQRVAITLCLGKPAD---IYLIDEPSAHLDSEQRITASKVIKRILHAKKTAFIVEHDFIMATLADRVIVY..................................... 539
3 -22.900[R] COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog  ali follow..  21  57...............................................................................................................................................................................................................................................................................................................................................NKCPFDAIMIIGLPEALQEPTHRYGPNGFALFGLPVPRIGKVTGILGPNGIGKSTSVQILSGTLVPNFGQGKGDWDTVAGTALHDYFKDVVDGKVKVSQKPQYVDLIPKAFKGKTSELLEKTDERGFLDEL--IDRLDLRGV-VERKISELSGGELQRVAIAACAARD----FYFFDEISPYLDIYQRINVARLVQEISK-DRAVLVVEHDLAILDMLTDVIHIAYG---EPAGFGVITLPKSVRVGINQYLKGYLPEENRFEVHPPREDAQFQSMVSFNSGDGFSLKATGGSLREGEVLGIVGPNGIGKSTFV-----------------------------------------------------------------------------------KVLAGEIKPDEGDPGIEVKISYKPQYIKADTPVSVQDFLRGITKRFGTSYYEVEIANPL----------------QLERIYE---------SLLTELSGGELQRVAIAACLSQEAD---LYILDEPSAHLDVEQRSMVTKVINRFAENQKTAMVVDHDIYMIMLSQRLLVFE-------GKPSVYGEAHGPFSMESGMN-RFLENL.. 550
4 -20.200[R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase  ali follow..  20  166.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IELLRQVEIP--ALDRYAFQYSGGMRQRAMIAMAL--ACKPQLLIADEPTTALDVTTQAEILDLISRLQAHGMAVLFITHDMGVVAQIADDVLV-----MHHGVVKEYGTVEQIFHKPQDPYTRMLIGSVLKLEQKAEIRLARPKDLSMHFGEMKALDGVSIKLLPGETLGIVGESGSGKTTMGRSIMRLYDPTAGEMLYRRADGSVVDLSKIEGKEKAARRELRMVFQDPFGSLNPRMTV--------------------------------------------------------------------------AQVIGEPLLV------GIAKGKELEERVCSLMEQVGLDPSGRERYPHAFSGGQRQRIGIARAITLRPR---IIVADEATSALDVSVRFQVLDLLMKLQELGLAYIFISHDIGVIRMCDRVGVM------YRGKLVEVGEAEKVCNAPDPYTQALLSAI.. 562
5 -19.800[P] COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA  ali follow..  21  107...................................................................................................................................................................................................................................................................................................................................................................................................................................................................AEIIQDEVKDAPRCMQLAQQFGITPL-LDRRFKYLSTGETRKTLLCQALMSE----LLILDEPFDGLDVASRQQLAERLASLHQSGITLVLVLNFDEIPEFVQFAGVL------ADCTLAETGAKEELLQQALVAQLAHSEQLEGVQLPEPDEPSARHNNGVVSYNDRPILNNLSWQVNPGEHWQIVGPNGAGKSTLLSLI---------------------------------------TGDHPQ-----------------GYSNDLTLFGRRRG--------------SGETIWDIKKHI---------------YVSSSLHLDYRSTTVRNVILSGYFDSIGIYQAVSDRQQKLQWLDILGIDKRTADAPFHSLSWGQQRLALIVRALVKHPT---LLILDEPLQGLDPLNRQLIRRFVDVLISEGETQLLFHHAEDAPACITHRLEFVPD-----GGLYHYALTK................... 492
6 -19.400[R] COG4172 ABC-type uncharacterized transport system, duplicated ATPase component  ali follow..  19  70..................................................................................................................................................................................................................................................................................................................................................................................................................................SVDYRGRNLLTLSKSDLNKSMIFQEPMTSLDPLYSIGNQLIEPIRRHLKLLRLVHIP--RMKSYPHEMSGGQRQRVMIAMALAND----ILIADEPTTALDVTIQAQILMLLAELRKLGMAIVFITHDLGIVRRFADRVYV-----MRQGEVVEEGEAGAIFANPQHAYTKMLLAAEPTGSKAAPPANAGGGFLAGEPLMLRAVDDISIRLQRNQTIGIVGESGSGKSTLGRALLRLLPSDGLIRFGDRDISTADRQAMRPLRRQMQLVFQDPFGSSPRMTVGQVIT-------------------------------------------------------------------EGLLVHEPNLSGKQ-----------------RDQRAVEALREVGLDPNARNRYPHEFSGGQRQRIAIARAMILKPK---MVVLDEPTSALDRSVQKQIVELLRKLQADELSYLFISHDLSVVRAADYIIVM------KQGKIVEEGPTEAIFSNPQVYTQTLMA.... 527
7 -18.500[H] COG4138 ABC-type cobalamin transport system, ATPase component  ali follow..  26  16.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LGPLSGEVRAGEILHLVGPNGAGKSTLL-----------------------ARMAGMTSGKGSIQFAGQPLEAWSATKLALHRAYLSQQQTP---------------PFATPV-------------------------------------WHYLTLHQHDKTRTELLN--------------------DVAGALALDDK-LGRSTNQLSGGEWQRVRLAAVVLQANPAGQLLLLDEPMNSLDVAQQSALDKILSALCQQGLAIVMSSHDLNTLRHAHRAWLL------KGGKMLASGRREEVLTPP............. 224
8 -18.200[P] COG4559 ABC-type hemin transport system, ATPase component  ali follow..  25  11.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TDLSYSVAGRELLSKLKFHLQSGEMLAVLGRNGAGKSTLL-----KHLTGELGKSG-------------------VELFGQPLRDIKPAEAAKRRAVLPQQTPL---------------SFAYEVL---------------------------DVVLLGRIPHGQRETVQDRAIAAACLERVGLSGYE-------------------------TRDVLTLSGGEQQRVHFARTLAQGVIGERVLLLDEPTASLDLAHQHATLRLARELCREGVGVLAVLHDLNLAQYADRVLML------AEGHVIACDHPAVALTPE............. 234
9 -17.800[G] COG1129 ABC-type sugar transport system, ATPase component  ali follow..  17  44.............................................................................................................................................................................................................................................................................................................................................................................................................................EAIAAGVGIVFQEFSLIPYLNAVE--NMFLAREIRGPLRLLNKGAMRKRAAEIMGRLAVDVP---LDVPVHRLSVAQQQFVEIAKALSLDA---ILVLDEPTATLTPSETEHLFNVMRELRRQGVAIIFISHHDEIFEICDRITVL------RDGELIGSCLTSEVDNDREMMVGRRIEAS-----PKPQIDPSAAKVIEVEELQLKKGPVSRFSLRKGEILGFAGLVGSGRTETV-----------------------LAMLGAHSASRKIKLDGVDTR--------------------LSGPDDALMRGIG------------------------EEGLITSFSILQNISLNNYRK--------------------YRKAHWFLDLKKELEHTTKAMAQVQVKAQGPYARVDTLSGGNQQKIVIARWLNHDMR---VLIFDEPTRGIDVGAKAEIYSLMREFAARGHSIIMISSELPEVIGMSDRVCVFRSGGIVATVEGEDINSETIMTN---ATTGRVEHV.. 471
10 -17.600[EJ] KOG0062 ATPase component of ABC transporters with duplicated ATPase domains/Translation elongation factor EF-3b  ali follow..  17  3........................................................................................................................................................................................................................................................................................................................................................................................................................EGIEIVNTDFSLAYGSRMLLNKTNLRLLKG----HRYGLCGRNGAGKSTLMRAIANG-AALESVGFDEERRAQTVGSLSGGWKMKLELARAMLQK----ILLLDEPTNHLDVSNVKWLEEYLLEHT--DITSLIVSHDSGFLTVCTDIIHYENKK-YYKGNLAAFVEQKPEAKSYYTLTDSNAQMRFPPPGILTGVKSNTRAVAKYPGAQKPSLSHVSCSLSLSSRVACLGPNGAGKSTLI---------KLLTGELVPNEGKVEKHPNLR--QHALQHVNEHKEKTANQYLQWRYQFGDDREVLLKESRKISEDEKEMMTKEIDIDDGRGKRAI--GRQKLKKSFQYEVKWKYWKPKYNSWVPKDVLVEHGFEKLVQKFDDHEASREGLGYRELIPSVITKHFEDVGLD-IANHTPLGSLSGGQLVKVVIAGAMWNNPH---LLVLDEPTNYL---DRDSLGALAVAIRDWSGGVVMISHNNEFVGAL........................................... 530
11 -17.600[E] COG4161 ABC-type arginine transport system, ATPase component  ali follow..  23  18.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LFDITLDCPQGETLVLLGPSGAGKSSLL---------RVLNLLEMPRSGT-------------LNIAGNHFDFTKTPSDKAIRDLRRNV-----------------------------------GMVFQQYNLWPHLTVQQNLIEAP----------------CRVLGLSKDQALA---------RAEKLLERLRLK--YSDRYPLHLSGGQQQRVAIARALMMEPQ---VLLFDEPTAALDPEITAQIVSIIRELAETNITQVIVTHEVEVARTASRVVYM------ENGHIVEQGDASCFTEPQTEAFKNYLSH... 242
12 -17.300[E] COG4598 ABC-type histidine transport system, ATPase component  ali follow..  29  21.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LKGVSLQANAGDVISIIGSSGSGKSTFL----------RCINFLEKPSEGSIVVNG-----QTINLVRDKDGQLKVADKNQLRLLRTRLTMVFQ---------------HFNL----------------HMTVLENVMEA-----------------------IQVLGLSKQEARE---------RAVKYLAKVGIDERAQGKYPVHLSGGQQQRVSIARALAMEPE---VLLFDEPTSALDPELVGEVLRIMQQLAEEGKTMVVVTHEMGFARVSTHVIFL------HQGKIEEEGAPEQLFGNPQSRLQRFLKGSLK 257
13 -16.900[P] COG1122 ABC-type cobalt transport system, ATPase component  ali follow..  21  98..........................................................................................................................................................................................................................................................................................................................................................................................................................................................DELVFPLIQQGFGWGEAKREAEEV--CEELGIGGL-LERKTYELSTGELQLVQIAAALASK----ILVFDEPFANLSRKNVLKVIKILR-----DYPHLVSEHRLEFSSFFEKTINL----------------------------------------------LECEDFEIPEVEPGEAVYDGLIELREGELIALVGDNGAGKTMM--------------------------LKKIATEMRKLGLDFSIVLQNPSY---------------------------------------------------------------------------------------HLVEDSVGKEVDL-----------ETAKEFGIESL-LSRHPQSLSMGQMKRVAIAKAFKSK-----ILLLDEPTAGQ---DCNFRRRLLYLLRKHRKSAIIATHDPYVAEHCDRKVEL..................................... 370
14 -16.500[U] KOG0058 Peptide exporter, ABC superfamily  ali follow..  17  250....................................................................................................................................................................................................................................................................................................................................................................FTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTS--DTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVY----------KLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQYEFVLGDCMEVYSGLMQGVGAAEKVF--------EFIDRQPTMVHDGSLAPDHLEGRVDFENVT---LQNVSFSLSPGKVTALVGPSGSGKSSCVNILE------------------------YPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARS------------ITDNISYGLPTVPFEMVVEAAQK----------------------------------------ANAHGFIMELQD-------------GYTETGEKGAQLSGGQKQRVAMARALVRNPP---VLILDEATSALDAESEYLIQQAIHGNL-QKHTVLIIAHRLSTVEHAHLIVVL------DKGRVVQQGTHQQLLAQGGLYA......... 735
15 -16.300[R] KOG0927 Predicted transporter (ABC superfamily)  ali follow..  15  112........................................................................................................................................................................................................................................................................................................................................................................................................KSSLLAVLGGREVPVPPHIDIFHLTREIPASSKSLQCVMEVDEERIKLEKLAEELAMSEEDDAQEQLIDIYERLRILHGLGFDKAMQQKQAKDFSGGWRMRIALARALFVK----LLLLDEPTNHL---DLDACVWLEEELKTYKRILVLISHSQDFLNG----------------------VCTNIIHLTGKRLKYYTGNYEAFVRTRMELLENQMKQYNWEQDQISHMKNYIARFGHGSAKLARQAQSKEKT------LAKMVAQGLTEKVSDDKVLNFYFPSCGKVPPVIMVQNVNFRYNDET------------PWIYKNLEFGIDLDTRLALVGPNGAG--------------KSTLLKLLYGDLVPTSGMIRKNSHLRIARYHQHLHELLDLDLEYMMRAFPDVKEKEEMRKIIGRYGLTGRQQVCPIRQLSDGQRCRVVFAWLAWQVPH---LLLLDEPTNHL---DMETIDALADAINDFDGGMVLVSHDFRLINQV........................................... 569
16 -16.300[CO] COG4987 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components  ali follow..  22  287....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ALAAFEALAPVTGAFQHLGQVIASAVRISDLTDQKPEVT----FPDTQTRVADRVSLTLRDVQFTYPEQSQQALKGISLQVNAGEHIAILGRTGCGKSTLLQQLT----------------------RAWDPQQGEILLNDSPIASLNEAALRQTISVVPQRVHLFSAT------------LRDNLLLASPGS-----------------------------SDEALSEILRRVGLEKLLE------------------------DAGLN-SWLGEGGRQLSGGELRRLAIARALLHDA---PLVLLDEPTEGLDATTESQILELLAEMM-REKTVLMVTHRLRGLSRFQQIIVM------DNGQIIEQGTHAELLARQGRY.......... 566
17 -16.200[P] COG1121 ABC-type Mn/Zn transport systems, ATPase component  ali follow..  20  9.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ENLTVYQGNYLAIRDVSFNLLPGTDTAIVGPNGAGKSTLVKAIL------------------------IPRRVGQIEIFGRPITKLGNLRHLL--------------------------------------------------------YMPQNFIFDRSFPISVEELVGLGWVAEARHQKSSFLSKLRIQSREKSAAIATALKRTDTYHLR-NQAIGTLSGGQLKRILLAYCLVIPRK---ILVLDEAFAGVDMQGAADFYAMLNELKQEGWTVLQVSHDIDMVSRCDRVLCLN-------QTVVCTGQPEIALSPQN............ 241
18 -16.200[E] COG1126 ABC-type polar amino acid transport system, ATPase component  ali follow..  28  17.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LHDINLNITQGEVVVIIGPSGSGKSTLL----------RCINKLEVITRGQLIVDGLDVNSPNIDERQ-----------------------------------------------------LEAGMVFQQFYLFPHLTALENVAFGP----------------TKVRGTSKEEAKK---------QALALLSKVGLE--RAHHYPAELSGGQQQRVAIARALAVKPK---LMLFDEPTSALDPELRHEVLTVMKDLAEEGMTMVIVTHEVGFAQVASRLIFID------KGRIAEDGDPDSLISNPPSRLREFLQHV.. 239
19 -16.100[R] COG4618 ABC-type protease/lipase transport system, ATPase and permease components  ali follow..  20  173.............................................................................................................................................................................................................................................................................................................................................................................................................................................LVSLTILTNIFSQKPIRDTMVENMARNRQLEASRRNAEVVQAMGLAYLAANRKAGDVAGNLAKSLRVVLQSAILAVGAWLVIREASGGV-------IASSIMMGRALAPVDLAISNWKSFVAARQSWARLR------------------------ELFAQMPANAAAMALPKPEKELRVENVIVPPGERKPTVTGLGFVVTAGNALGIIGPSGSGKSTL---------ARILTGAWMPAAGK-------------VRLDGASFDQWDRETLGRHIGYLPQGVELFDGTIGENISRFDDNPDPEAI----IAAARAAGAHELILR-FEKGY------------------------------------------------------------SDIGEAGSTLSAGQRQRIGLARALYGDP---FIVVLDEPNANLDAEGEAAVVKAITSVKARGGIAVVVAHRPSAIGAVDYILMM------EDGRMKAFGPRDEVLS............... 561
20 -16.000[CO] COG4988 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components  ali follow..  18  207....................................................................................................................................................................................................................................................................................................................................................................................................................................................DRLQALTTIRLFDRTTAETEHMRGASEVRIAFLSSAVLEFFTSISIA------------TAVYFGFSYIGEL-----------------NFGYYGASVTLFAGLFVL------ILAPEFYQPLRDLGTYYHAKQLAVGAAESIVDFLQTEVDTLHSGERHLSDNDDIEIIANDLVVLSPQGKR--AGPLSFTLQSGKTTALVGPSGAGKTSLIN------------------------ILGFMPYQGSLTINGIELRELDHAQWRQTISWVGQNPLLLYGT------------------------------------------------------RDNVTLGKHNIADEQVTQTLQAAYAQEF------------VEQQGLD-YPISDRSAGLSVGQAQRLALARAILQN---GRFWLLDEPTASLDARSEQYVMRGLTESIQ-QRTALFVTHQLQPLQSVEQILVM------ENGLLVQAGHFEDLSQQSGLFA......... 576
21 -15.900[P] COG3638 ABC-type phosphate/phosphonate transport system, ATPase component  ali follow..  25  41.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LDNINFELHAGEFVAIIGRSGAGKSTL-----------------------------LHILNGTIPTSAGEI----------------NYHENGDTQNIAALTTKQMRKWRAKC-----------GMIFQDFCLVPRLDVITNVLLGRLSYTSTLKSFFKLFSEQDQ------------------ARAIELLQWLNML--HALQRAENLSGGQMQRVAICRAMMQNPK---ILLADEPVASLDPKNTTRIMNTLQKISENDIAVIVNLHSVDLVKDCTRVI------GIAHGRIIFDGPPSMLND............... 262
22 -15.800[P] COG4778 ABC-type phosphonate transport system, ATPase component  ali follow..  21  18.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GVRLPVLNRASLTVNAGECVVLHGHSGSGKSTLLR-SLYANYLPDEGQIQIKHGDEWVDLVTAPA-RKVVEIRKTTV-----------------------------------------------------GWVSQFLRVIPRI---------SALEVVMQPLLDTGVPREA-----------------CAAKAARLLTRLNVPERLWHLAPSTFSGGEQQRVNIARGFIVDY---PILLLDEPTASLDAKNSAAVVELIREAKTRGAAIVGIFHDEAVRNVADRLHPM..................................... 222
23 -15.600[R] COG4619 ABC-type uncharacterized transport system, ATPase component  ali follow..  27  23.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LNNINFSLRAGEFKLITGPSGCGKSTLL---------------------------------KIVASLISPTS----------------------------------GTLLFE----------GEDVSTLKP---------------EIYRQQVSYCAQTPTLFGDTVYDNLIFPWQIRNRQPDPAIFLDFLERFALPDSILTKNIAELSGGEKQRISLIRNLQFMPK---VLLLDEITSALDESNKHNVNEMIHRYREQNIAVLWVTHDKDEINHADKVITL------QPHAGEMQEARYELA................ 225
24 -15.500[V] COG1132 ABC-type multidrug transport system, ATPase and permease components  ali follow..  17  190.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................RNISKNMQNTMGEVTTSAEQMLKGHKEVLIFGGQKVETERFDAVSNRMRQQGMKLVSASSIS---------DPIIQLIASFALALVLYAASFPSVMET---LTAGTITVVFSAMIALMRPLKSLTNVNTQFQRGMAACQTLFSILDMEQEKDEGKLFYYPGKDTPALNDINIHLEAGKTVALVGRSGSGKSTIAN----------------LLTRFYDVSEG-------ILLDGHDLRDYRLGALRNQVALVSQNVHLFNDT------------VANNIAYARNEQYSRAEIEEA---------------------------------------ARMAYAMDFINKMEH-----------GLD-TVIGENGIMLSGGQRQRIAIARALLRNC---PILILDEATSALDTESERAIQAALDELQ-KNRTSLVIAHRLSTIEKADEIVVI------EDGRIVERGVHAELLVQQGVYAQLN...... 576
25 -15.400[V] COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain  ali follow..  23  338....................................................................................................................................................................................................................................................................................................................................................................................................................................................ATLQSIETLKASGLESDFFSRWSGYYTKALNSQQELGITNQTFSVLPTLLSA--------LSAMLLLIVGGFRVMDHLSIGMLIAFQGLMSGFQQPVNNLVNFGTTLQELEGNLIRLDDVLDNPVGEVGGKTSSSSLQALPKLQGY-KNITFGYSRLEAPL------------------------IENFNLSIKPGQRVALVGGSGSGKSTIA-----------------------KLVSGLQPWTGEIYFDSQPREEISLQLLTNSVAMVEQEILLFGGT------------------------------------------------------RDNLTLWDTTVPDKNLMRACQDAAIA------------DVIFSMSGGYAELIEGAANLSGGQRQRLEIARALVNNP---SILVMDEATSAL---DAETEKIIDQNLRRRGCTCIIVAHRLSTIRDCDQIIVL------ERGKVVQQGTHQELWQVEGAYS......... 705
26 -15.400[P] COG4604 ABC-type enterochelin transport system, ATPase component  ali follow..  24  5.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NDVNKKYQQTTVLNEINERIPSGGITSIIGPNGAGKSTLLSIM-------------------------LAADSGNVLFNGLDVAKTSGDKLATILSVLRQENHFTSRLTVSDLVGF--GRYP-----------------------------------------------YSRGRLNKNDRQHIDAAMEFLNLMPLKDRYLD-----------------ELSGGQRQRAYVAMVLCQDTS---YILLDEPLNNLDMKHCVAMMKQLRRAADEHKTIILVIHDINFASASDHIIAM------KNGEVIYRGAPAEIMQPS............. 227
27 -15.400[J] KOG0066 eIF2-interacting protein ABC50 (ABC superfamily)  ali follow..  18  460..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................LNDTFAELRILAGLGFSKEMQDRPTNKFSGGWRMRVSLARALYLE----LLMLDEPTNHL---DLNAVIWLDNYLQGWKKTLLIVSHDQSFL----------------------DNVCNEIIHLDQKKLQYYKGNYSMFKKMYVQKRREMIKEYEKQEKRLRELKA------------GQSKKAAEKKQKESLTRKQEKNKSKQQKQDEDEGPQELLARPKEYIVKFRFPEPSQLQPPILGVHNVTFAFPSQKPLFIKVDFGIDLTSRVAIVGPNGVG--------------KSTFLKLLLGELEPQEGEQRKNHRLHVGRFDQHSGEHLTAEESAAEYLQRLFNLPHEKARKLGSFGLVSHAHTIKMKDLSGGQKARVALAELCLSAPD---VLILDEPTNNL---DIESIDALAEAINEYEGGVIIVSHDERLIRET........................................... 854
28 -15.200[RK] KOG2355 Predicted ABC-type transport, ATPase component/CCR4 associated factor  ali follow..  17  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAEKDATASGDDAIRVSGMQFA-FFDFNLDLPAGSRCLLVGANGSGKTTLL---------KILAGKHMVGGKNVVQVLSRSAFHDTQLVCSG------------------------------------------------------------DLSYLGGSWSKTVGSAGEVPLQGDFSAEHMIFGVEGTDPVRREKLIDLLD-------------------INLQWRMHKVSDGQKRRVQICMGLLHPFK---VLLLDEVTVDLDVVARMDLLEFFKEEDQRGATIVYATHIFDGLETATHLAYI------QDGELNRLSKMTDIEELKTS........... 242
29 -15.200[R] COG3845 ABC-type uncharacterized transport systems, ATPase components  ali follow..  19  30.....................................................................................................................................................................................................................................................................................................................................................................................RGTIHGIVGENGAGKSTLMSILYGFYQADSGEIRVGGKPASIKTPNDAIALGIGMVHQHFMLVDNFSVLENIILGAESDALLKSSIAKARSELERLEREYGLEVDPDAIIEELPVGLQQRVEILKALYRG--AEILILDEPTGVLTPAEADHLFRILKQLKEQGKTVVLITHKLREIMAITDNVSV-----MRQGTMVATRETSKTTVGE---LAELMVGRRVLLRVEKGEAEAGAVKLAVKNLTVKDVDDISFDLRAGEIVGIAGVAGNGQSELL-----------------------EAISGIRHAVSSVMLDGKPIDLTGAADPGELRDR-------LAHVPEDRHHVGLVLAFE------------------ENENSILGYHDDPRYLKGPFLNVD--AIMADAKDKIEKYDIRPGNPRL---------------------------KTANFSGGNQQKIVLAREMEQ---DPGVLIVGQPTRGVDVGAIEFIHKRLIAMRDQGKAVLVVSVELDIRSLSDRILVM-------AGRIVGERGPE................... 490
30 -14.800[PH] COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components  ali follow..  24  9.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGKSTLLRSLA------------------------MKPRGGSVLLEGRAIAKLPTKEVAKELAILP------------------------------------------QGPSAPEGLTVHQLVKQGRYPYQNWLKQWSKED-----EEAVERALKATKLEDMADRAVD-----------------SLSGGQRQRAWIAMTLAQETD---IILLDEPTTYLDMTHQIEILDLLFELEKEDRTIVMVLHDLNACRYAHHLVAI------KDKRIYAEGRPEEVITCD............. 233
31 -14.600[E] COG0411 ABC-type branched-chain amino acid transport systems, ATPase component  ali follow..  25  17.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LQDVNIEVPQGTIFGLIGPNGAGKTTVFNLI----------------TGLLEPTGGTLTFGGTSLVGKKPHQITQMGIARTFQNI-----RIFKEMTLLEN-------------------------VVVGMHRHLDYGAPGLLLSLPGYRAAERRARDRALELLSWVKLD-----------------------------KAGDIADNLSYGDQRKLELARALA---TEPKLLLLDEPVAGMNTGEKVDLMAEIENIRARGYTIFMIEHDMRVMGLCERIAVLN-------GRIIAEGPPEAIRNNPEAYLGR....... 249
32 -14.600[P] KOG0056 Heavy metal exporter HMT1, ABC superfamily  ali follow..  18  301..........................................................................................................................................................................................................................................................................................................................................................................QGGGTGSMGLFNNLRTFLWIRVQQYTTREIEIELFRHLHQLSLRWHLQRKTGEVLRVMDRGTDSINNLLNYIVFSIAPTILDLLVA--NWWFGLIVFLTMFLYIASTIAI-TEWRTKYQRRMNLADNEQRARSVDSLL--NFETVKYYGAEHAILKYQKEEFLSMLTLNMLNTAQNIILCLGLLAGSLLCVYLVVH---HQTLTVGDFVLFSTYLMELYMPLNWFGTYYRAIQKLKEEEEIVDAPGCSPLLTAGGGIE-LRNVSFTVPAGKTVAIVGPSGAGKSTIMR-LLFR----------------------YDVQTGAILIDGQNIKLVQQQSLRKAIGVVPQDTVLFNNT------------IFYNIEYAKLGA-----------------------------SDEAVYEAARAADIHERILGFPE------------------------KYTKVGERGLRLSGGEKQRVAIARTLLKAP---IIVLLDEATSALDTHTERNIQAALARVC-ANRTTIIVAHRLSTIIHADEILVL------QQGSIAERGRHEELVLREDG........... 803
33 -14.300[U] KOG0057 Mitochondrial Fe/S cluster exporter, ABC superfamily  ali follow..  20  283..........................................................................................................................................................................................................................................................................................................................................................................................KIRKAMNEAENDASTRAIDSLINYETVKYFNNEDY-----------------------EARKYDQLHENYEDAALQSRKSFALLNFGQSFIFSTALSTAMVLCSQGIMNG--------QMTVGDLVMGLLFQLSLP-LGVVYSDTVQGLVDMKSMFKFLEERSDIGDKDIDRKLPPLVLK--------GGSI-------------ENVHFSYLPERK--------------------------LDGISFEVPAGKSVAIVGSSGSGKSTIL----------RMIFRFFDVDSGNVKIDGQDIKEVRLESLRSSIGVVPQDTV------------LFNDT------------IFHNIHYGNLSA-----------------------------TEEEVYNAARRAAIHDTIMKFPD------------------------KYTAVGERGLMLSGGEKQRVALARAFLKSP---AILLCDEATSALDSKTEAEIMKTLRSL-ASNRTCIFIAHRLTTAMQCDEILVM------EKGKVVEKGTHEVLLGKSGRYAKLWTQQ... 674
34 -14.300[O] COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components  ali follow..  25  228....................................................................................................................................................................................................................................................................................................................................................................................................................................................DSLLNFETVKYFGNEAMEAKRFDGAMAEKAATQTWTSLGWLNFGQAVIFGAGMAIVMVMSAMEVQKGTQ---------SLGDFVFINALLMQLSIPLNFIGFIYREIRQGLTDIEQMFDLLDVKQ----------------EVKDKPGAPALKVDSGA--ISFKDVHFAYDPQRPI---------LRGISFDVPAGKTVAIVGPSGAGKSTIS-RLLFR----------------------YDIQSGSITIDGQDVRDVTQESLRKFIGMVPQDTVLFNDT------------IAYNIRYGRTDA-----------------------------SEEDVEKAAELAQIAG-----------FIKHLPD-------------GYSMVGERGLKLSGGEKQRVAIARTILKAP---PILILDEATSALDTATEQEIQSALDIV-SRGRTTLVIAHRLSTVIGADEIIVL------KDGLIAERGTHRHLLDQKGLYASMWDRQ... 598
35 -14.100[D] COG2884 Predicted ATPase involved in cell division  ali follow..  27  19.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LDNVNVKIDKGEFVFLIGPSGSGKSTF-------------------------------------------------------------MRLLLGAETPTSGDVRVSKFHVNKLPGRHIPRLRQVGCVFQDFRLLQQKTV---------------------ENVAFALEVIGRRSDAINQVVPDV------LETVGLS--KANRLPDELSGGEQQRVAIARAFVNRP---LVLLADEPTGNLDPDTSKDIMDLLERINRTGTTVLMATHDHHIVDS............................................ 203
36 -14.000[R] COG2401 ABC-type ATPase fused to a predicted acetyltransferase domain  ali follow..  15  21....................................................................................................................................................................................................................................................................................................VELDNGLTLYMSGIAAWLFEGDVVEVVIKNEPKEIYGRKILFFADYESRNLELPRYSFGKEVYRYRI---RAREAVYEKDFERIA-ELEQYHYASQKSKVAYDCGNLIEANTKPVCECGSRNVHIVEIK-GSTPASRFLIFELVERQPFEPEVPVPLMHRKLDGKIVENIRERVELFRKLRSRFSLKVARHRLWEEASEEAMKKCNSAASRIARVVVHPDYRADGLEMRMRKHLVETIAQMARFGKPVLYKPLSEEAERYIRKFLEEDEVARGHGGKLCVSGSVKPLEKLKRNVSKLFASTLDLEKVSDEVRTVLESFGVRQRVVERYVLRDVNLEIKPGEIVAVVGASGSGKTTF-------------------------------------------------------------LRLIVGEALKLDDDVYKPSS-------GMVEVVVDSIAAMIPSELEPQI-------------------------------TEKSILEQIFDITGDIHLAVEVLNRAGIS-VLYRARFNELSTGQKERFKLAACLAKKPS---LMLVDEFAAHLDEMTAVRVARKISELREAKITLIAVTHRKEVINSPDRILYV------GYGGVTES....................... 619
37 -13.900[Q] COG4181 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component  ali follow..  28  26.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LTGVELVVKRGETIALIGESGSGKSTLLA----------ILAGLDDGSSGEVSLVG----KPLHQMDEEARAQLRAQHVGFVFQSFMLIPTLNA---------------------------------------LENVELPALLRGENSGQSK--------------------------------AGAKALLEQLGLGK-RLDHLPAQLSGGEQQRVALARAFNGRP---DVLFADEPTGNLDRQTGDKIADLLFSLREHGTTLILVTHDPALAARCDRRLRL..................................... 219
38 -13.500[E] COG0410 ABC-type branched-chain amino acid transport systems, ATPase component  ali follow..  24  5.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DKVSTYYGKIQALHDVSVEVKKGEIVTLIGANGAGKSTLLM---------------------------------------------------TLCGSPQA----------------ASGSIRYE--GEELVGLPSSTIMRKSIAVVPE---------GRRV--------FSRLTVEENLAM-FTDKDDYQVQMDKVLELFPRLKE------RYEQRAGTMSGGEQQMLAIGRALMSKPK---LLLLDEPSLGLAPIIIQQIFEIIEQLRREGVTVFLVEQNANQLADRAYVLENG--------RIVMHDTGAALLTNPK............ 225
39 -13.300[O] COG4133 ABC-type transport system involved in cytochrome c biogenesis, ATPase component  ali follow..  24  17.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FSGLSFTLNAGEWVQITGSNGAGKTTL-------------------------------------------------------------LRLLTGLSRPDA------GEVLWQ----------GQPLHQVRDSYHQNLL-------------------WIGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFE-DIPVNQLSAGQQRRVALARLW----TRATLWILDEPFTAIDVNGVDRLTQRMAQHTEQGGIVILTTHQ.................................................. 185
40 -13.300[R] COG0488 ATPase components of ABC transporters with duplicated ATPase domains  ali follow..  21  102..........................................................................................................................................................................................................................................................................................................................................................................................................................................LTRLDEVYALYADPDADFDKLAAEQANLEAIIQAHDGHNLDNQLERAADALRLDAKIEHLSGGERRRVALCRLLLEK--PDMLLLDEPTNHL---DAESVAWLERFLHDYEGTVVAITHDRYFLNVAGWILELDRGEGIQNPKGRQAKSKARMARFDELNSGEYQKRNETNELFIPPGPRLGDKVIEVQNLTKS-IDDLSFSIPKGAIVGIIGANGAGKSTLF---------RMLSGQEQPDSGSVT----MGETVVLASVDQFRDSMDDKKTV--WEEVSNGQDILTIGNFEIPSRAYVG---RFNFKGVDQQ-----------------------------------------------------------------------------------KRVGELSGGERGRLHLAKLLQR---GGNVLLLDEPTNDL---DVETLRALENAILEFPGCAMVISHDLD--RIATHILDYGDEG................................. 519
41 -13.000[P] COG4107 ABC-type phosphonate transport system, ATPase component  ali follow..  22  21.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................CDRISFDLYPGQVLGIVGESGSGKSTLLGAIADHIAVDHGNVTYISRSGEDLEIFQLAEAKRLMRTEWGFVQQNPRDGLRMRVSAGANIGERLLDIGVRHYGNIR-------------------------------------------------------------------------------DEAAHWLREVEIDPTRIDDLPAQFSGGMQQRLQLARVLV---TRPRLILMDEPTGGLDVSVQARLLDLLRSLVNFHLSVIIVTHDIGVVRLAHRLLVM--------GQVVESGLTDQVLDDPHPYTQLLVSAAL. 255
42 -12.600[CP] COG4555 ABC-type Na+ transport system, ATPase component  ali follow..  18  4.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGNGAGKTTLRMIASLLEPSQTVDGFDTVKQPAEVKQRGGETGLYDRMTAKENLQYFGRLHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPD---IILFDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQACDSVIMI------HSGEVIYRGALESLYESERS........... 230
43 -12.500[Q] COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component  ali follow..  21  22.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................WEDVTLDIPAGEVSVLLGPSGTGKSVFL-----------------------KSLIGL----------------------------------------------LRPERGSILIDGTDIIECSAKELYEI---------------------RTLFGVLFQDGALFGSMNLYDNTAFPLREHTKKKESEIRDIVMEKLQLVGLGGDEGEISGGMRKRAGLARALV---LDPQIILCDEPDSGLDPVRTAYLSQLIMDINAQDATILIVTHNVNARTVPDNMGMLF------RKHLVMFGPREVLLTSDEPVVRQFLN.... 243
44 -12.500[R] COG1137 ABC-type (unclassified) transport system, ATPase component  ali follow..  22  16......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RKVVSDVSLTVNSNEIVGLLGPNGAGKTTTFYMVVGLVRQDQGKI-------DISLLPMHNRAQRGIGYLPQEASIFRRLTVYEVLEIRKDLTPQQRR-ELIEEFNISHIR-DNLGQALSGGERRRVEIARALA---ANPKFILLDEPFAGVDPISVSDIKKIITDLRNRGLGVLITDHNVETLDVCERAYIVGA------GKIIATGTPEQVMNDEQ............ 229
45 -11.800[H] COG3840 ABC-type thiamine transport system, ATPase component  ali follow..  22  6....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DITWLYHHLPMRFSLTVERGEQVAILGPSGAGKSTLLN------------------------IAGFLTPAS-LTIDGVDHTTTPPSR-------------------------------------------RPVSMLFQENNLFSHLTVAQNIGLGLNPGLKLNA---QQEKMHAIARQ------------------------MGIDNLMARLPG-ELSGGQRQRVALARCLVRE---QPILLLDEPFSALDPALRQEMLTLVSTSQQQKMTLLMVSHSVDAARIATRSVVV------ADGRIAWQGMTNELLSGKASASA........ 226
46 -11.700[Q] KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein)  ali follow..  23  103......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RPKTKTLLNNISGETRDGEIMAVLGASGSGKSTLI-----------------------------------------------------------------------------------DALANRIAKGSLKGTVKLN---------------GETLQSRMLKSAYVMQDDLLFPMLTVEETLMFAAEFKKKLRVQALIDQLGIRNAIIGDEGHRISGGERRRVSIGIDII---HDPILLFLDEPTSGLDSTSAFMVVKVLKRIAQSGSIVIMSIHSHRVLGLLDRLIFLS------RGHTVYSGSPASLPR-ENENRTEFALDLIR 347
47 -11.400[P] COG1117 ABC-type phosphate transport system, ATPase component  ali follow..  18  28.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EDLHVYYGDNHAIKGVDLTFPENKVTALIGPSGCGKSTYL-----RALNRMNDEIDGCRMEGQILYDGININRKEVDLYN-------RKEIGMVFQ--------------------KPNPFTKSI-----------------------------------YENVAFGLKRHGMKNKKEIMERVEKSLRRAALWDEVKDDLG-------------KSALSLSGGQQQRLCIARAVAMQPK---VLLLDEPASALDPISTSKIEDLINELKNK--TIIIVTHNMQAARVSDYTSFF--------GEVVEFSGTSELFTNPQEISGNF...... 270
48 -11.200[V] COG4170 ABC-type antimicrobial peptide transport system, ATPase component  ali follow..  20  23.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VDRISMTLTEGEVRGLVGESGSGKSLIAKAICVSKDNWRITADRFRFNDIDLLQLTPRQRRKVIGHNISMIFQEPQSCLDPSESI--------------------------------------------------------------------------GLQLIQAIPGWTYKGRWWQRFHWRKRRAIELLHRVGIK--IMHSYPYELTEGECQKVMIAIALANQPR---LLIADEPTNAMEPTTQAQIFRLLARLNQNNTTILLISHDLQMMKWATRVNVL-------CGQTVESAVCEDLLSTPHHYTQALIRAM.. 262
49 -11.000[GM] COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component  ali follow..  15  3.................................................................................................................................................................................................................................................................................................................................................LSMTNQDKQIKEANEVVIQATNLGVSFHSGYRTDDYKSHIFNWFSRKSKTNEGQEESKIVWPLRNLDFTGYKGEILGKTTLCKMLSGILKPDEGELYVDGRVSALFSLELTGRENAYLNGMMDQIDQFIDEIHEFSGLGSFIDQPMKYYSSG--MKARLGFSVAAFLEPEILILDEALNTGDAAFGKKAAAKMKELVSKAKMVILVTHSLRYARKCDRLLWL------DRGEIRAIGEPAEVIEKYKETIPVKVRRPRKRLELKKTEANVKERTVVKAENIGMSLKNVSFDIKEGEVVGIIGHNGAGKSTL-------------------------------------------------------------CKLLTKILTPDEGELELSGETT--------------SLLSYGTGFNAQL------------GKDNVYLN------GMLLGIPKER----------VAQEYPNIVAFSELEKHMDKPVKSYSSGMKSRLGFSIAATLQPD---IFIIDEALSTGDVAFQQKASEKIQEMMERAKAVIIVSHSMKFVESCTRAIWL------EKGQVRFDGDPEEAVK............... 502
50 -10.800[IR] KOG0060 Long-chain acyl-CoA transporter, ABC superfamily (involved in peroxisome organization and biogenesis)  ali follow..  15  185.....................................................................................................................................................................................................................................................................................................IQNADQLLTQDVDRFCDGIVELYSNLSKPILDVFLYLFRLGTSLGFSSPSILFSYLLFTGVGLTYLRRPIGRLTVEEQALEGEYRYVNSRLIMNS-----EEIAFY---------QGNQSEKETIMSTFASLVQHLRKIILFRFSIGFVDNI------------VAKYLATVVGWYA-VGSSFFDHKPFIGMSRNQLMQEYYNSGRMMYKMAEAL---------------GRLALAGRDMTRLSGFTSRVDTLLNVLD------DVNSGNYKRTMVGEKEESSALIKSELVAGSGNLRVQDNVIRFDNVPLVTPNGDVL---------IERLNFEVPSGTNVLVCGPNGCGKSSL-----------------------FRVLGEL-----------------------------------------------------WPLFGGTLTKPAKGKLF-----YVPQ-YMTLGTLRDQ-YPDRPLDMIRKGVSDSDLEQMLEN--------------QLTHILEREGGWSAVQDWMDVLSGGEKQRIAMARLFYHKPQ---FAILDECTSAVSVDVEGAMYRLCREK---NITLFTVSHRKSLWKYHEYSLYMDGRGS................................ 646
51 -10.400[I] KOG0064 Peroxisomal long-chain acyl-CoA transporter, ABC superfamily  ali follow..  15  185.........................................................................................................................................................................................................................................................................................VNSMIRFLESKLSLAFRTRLVRHSYRLYFKNQNYY-HRLTEDISVFANSVAHLYSSLTKPCFDLMLIGL-TAHILRIVSPKFGQLVSEEANRYGYLRHIHSRIITNA-----EEIAFY---------GGHKVEMQQLRQAYNRLVNQMTTIFNQKLWFIMLEQFFMK----MVSLPILTGSDVGLGTVPNTAISESRVSERTQYLTTARNLLISAADAIE-----------------------RLMSSYKEIVSLAGYTFRVAGMMDVFEETALGVYCKTSVMESNQSNGIIEFRNGKPIAKGRIIYSDDPKNMSISLRAVPVVTPNCDIV---------VPKLTLCIEPGVHLLITGPNGCGKSSLF---------RILSGLWPIYAGELHIPRPVKDVPCMFYIPQRP---------------------------------YMS------------------GSLCDQI-----------------YPDTREDMKRKHITENELRSI---------------------LKMVSLEHIVVRDWKDILSGGEKQRMAIARLFYHRPR---YALLDECTSAVSIDVESSIYEIAKGM---GITLLTITHRPTLWKYHTHILEFDGLGN................................ 712
52 -10.400[P] COG1118 ABC-type sulfate/molybdate transport systems, ATPase component  ali follow..  28  18.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LNDISLDIPSGQMVALLGPSGSGKTTLL-----------------------RIIAGLEHQTS--------------------------------------------GHIRFHGTDVSRLHARDRKVGFVFQHYFRHMTVFDNIAFG-------LTVLPRRERPNA----------------AAIKAKVTKLLEVQLAHLADRYPA-QLSGGQKQRVALARALAVEPQ---ILLLDEPFGALDAQVRKELRRWLRQLHEEKFTSVFVTHDQEATEVADRVVVM------SQGNIEQADAPDQVWREPATFVLEFMGEV.. 240
53 -10.300[R] COG4674 Uncharacterized ABC-type transport system, ATPase component  ali follow..  22  21.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LNHLTFSMNPGELRVIIGPNGAGKTTFLD---------------------------------------------------VITGKVQP----------------TEGRVLFQ----------GKDIRKIPEYRIARLGV------GRKFQTPRV---YLNLTVAENLDLAVNRKKSVWGTLAEQRSVGGLLETIGLT--KAHLAAALLSHGEKQRLEIGMLVAQSPT---LLLVDEPVAGLTDEETENVGDLLLALAE-SHSIIVIEHDMEFVRQIARKVTVLHQ-----GSVLCEGNMDQIQNDPEVYLGE....... 245
54 -10.300[EP] COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component  ali follow..  20  24.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VNDLNFSLKQGETLGIVGESGSGKSQTVFAIM--------------------------------------------AKNGKITGSAKFEGKEILNLPERELN---------KVRAEQIAMIFQDPMTSLN----PYMKVSDQLMEVLMLHKGMGKAEAFEESVRMLEAVKIPEARKRITMYPH-----------------------EFSGGMRQRVMIAMALLCRPK---LLIADEPTTALDVTVQAQIMELLNELKRENTAIIMITHDLGVVGSCDKVLVM-------AGRTMEYGSVNDIFYNPSPYAEGLLSAI.. 257
55 -10.200[QP] COG4615 ABC-type siderophore export system, fused ATPase and permease components  ali follow..  13  55.............................................................................................................................................................................................................................................................................................................................................................................................................................................LGLLLLLMAVTLGSQLALTTLGHHFVYRLRSEFIKRILDTHVERIEQLGSASLLAGLTSDVRNITIAFVRLPELVQGIILTIGSAAYLWMLSGKMLLVTAIWMAITIWGGFVLVARVYKHMATL-----------------------RETEDKLYTDFQTVLEGRKELTLNRERAEYVFNNLYIPDAQESNIMMLGAIGLVFWMANSLGWADTNVAATYSLTLLF--LRTPLLSAVGALPTLLTAQVAFNKLNKFALAPFKAEFPRPQAFPNWQTLELRNVTFAYQD------NAFSVGPINLTIKRGELLFLIGNGSGKSTLMLLTGLYQPQSLLDGKPVSGEQPE------DYRKLFSAVFTDVWLFDQLLQLVEKWLAQLKMAHKLELSNGRIVNLLSKGQKKRVALLLALAE---ERDIILLDEWAADQDPHFRREFYVLLPLMQEMGKTIFAISHDDHYFIHADRLLEM------RNGQLSELTGEERDAASRDAVA......... 544
56 -10.200[R] COG4178 ABC-type uncharacterized transport system, permease and ATPase components  ali follow..  15  156............................................................................................................................................................................................................................................................................................................LTNHLTTDWLDQRAYYREQFID-------TIDNPDQRIQQDIDIFTTPNGPSNGTGSTLLFGAVESVISVISFTAILWNLSGRLAVFEFEIPRAMFWIVIVYVLLATIITFWIGRPLIGLNFANEKLNAAFRYALVRLRDAAEAVAFYRGEEAERKQLEQRFTPIID-------NYRRYVSRTIRFLGWNASVSQTIVPLPWILQAPRLFAGKINLG-------DVGQTATAFGNIHDSLSFFRNNYAAFAAFRAAIIRLHGLVVANARSRELPHVTAKSTNDGTVHVVAVE----VRTSAGEQ-----------------IDPLDLQLNCGSSLVITGRSGVGKTTMLR---------------------------------------------------SLAELWPY----------------------------------ASGTLSRETMFLSQ-YVPLGNLR-GVVCYPNAPADIPEDTVRDTLTKV---------ALNPLCDRLDEERD-----------AKILSPGEQQRIAFARILLTKPK---AIFLDESTSALDEGLEFALYQMLRSELP-DCIIVSVSHRRAVELLHAQQLELLGGGQ................................ 625
57 -10.200[R] COG4136 ABC-type uncharacterized transport system, ATPase component  ali follow..  19  5.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KNVSLRLPESRLLTNVNFTVDKGDIVTLMGPSGCGKSTLFSWMI--------------------------------------------------------------------------------------------GALAEQFSCTGELWLNEQRIDILPTAQRQIGILFQDALLFD--QFSVGQNLLLALPATLKGNARRNAVNDALERSGLEQDPATLSGGQRARVALLRALLAQPK---ALLLDEPFSRLDVALRDNFRQWVFSEVRAAIPVVQVTHD-DVPADSSVLDMAQWS.................................. 210
58 -10.100[P] COG4148 ABC-type molybdate transport system, ATPase component  ali follow..  28  4...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LNFSQTLGNHCLTINETLPANGITAIFGVSGAGKTSLIN------------------------ISGLTRPQK-IVLNGRV--------------LNDAEKGICLTPEKRRV-----------------------GYVFQDARLFPHYKVRGNLRYGMA--------KSMVDQFDKLVAL------------------------LGIEPL-LDRLPGSLSGGEKQRVAIGRAL----TAPELLLLDEPLASLDIPRKRELLPYLQRLTREINIMLYVSHSLDILHLADRVMVL------ENGQVKAFGALEEV................. 216
59 -10.000[V] COG4167 ABC-type antimicrobial peptide transport system, ATPase component  ali follow..  18  34..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SFTLREGQTLAIIGENLAGMIEPTSGELLIDDHPLHFGDYSFRSQRIRSTSLNPRQRISQILDFPLRLNTDLEPEQRRIETMRMVGLLPDHVSYYPHMLAPGQKQRLGLARALILRPK---VIIADEALASLDMSMRSQLINLMLELQEKGISYIYVTQHIGMMKISDQVLVM--------GEVVERGSTADVLASPHELTKRLIAGH.. 254
60 -9.720[P] COG1135 ABC-type metal ion transport system, ATPase component  ali follow..  26  8................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NKVFYQGDKQIHALKDINLFIPQGTIFGVIGSSGAGKSTLI---------------------------------RCVNMLEKPTSGQVIVDGVDLTTL---------SNPQLCAARRNIGMIHFNLLSSRT--------------VFENVALPLELAGQSQQHIE--------TKVTELLAL------------------------VGLS--KRESYPANLSGGQKQRVAIARALA---SDPKVLLCDEATSALDPATTQSILELLKEINRQNLTILLITHEMDVVKSICHEVAI------GGGELVEKGTVGDIFAHPKTLAHQFIRSTLD 246
61 -9.680[V] COG1136 ABC-type antimicrobial peptide transport system, ATPase component  ali follow..  26  23.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LKQISFSIEEGEFTAVMGPSGSGKTTLLN---------------------------------ISTIDRPDSG-------------------------------------DILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLL-------DTLTIG---ENIMLPLTLEKEAPSVMEEKLHGIAAKL------GIENL-LNKRTFEVSGGQRQRAAIARAV----HKPSLILADEPTGNLDSKATKDVMETLQSLNRDDHTALMVTHDPVSASYCRRVIFI..................................... 216
62 -9.610[R] COG3910 Predicted ATPase  ali follow..  18  26.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MRHLERLEFKTPITFFAGNNGSGKSTL-----------------------------LEGLAAGMTAYAIGNHGDVKGDLYLQHAETVAKAFYFARKKYPKIRMFLRAEDVLGY-------------------------------------------------IRRQNENALDDFRWEREKALKKGEDFPEETPEIFRGIVRNNSLDRRSHGEG----FLDIMHRRLHGAGLYFLDEPESPLSPQKQLELAAIIRQAADSGGQLIIATHSPVLLAIPE-IYYFDEDG................................. 230
63 -9.530[E] COG3842 ABC-type spermidine/putrescine transport systems, ATPase components  ali follow..  17  7........................................................................................................................................................................................................................................................................................................................................................................................FKNVNKYYDDLDLAVESGQFVTLLGPSGCGKSTTLRMQPSSGEIYLEGKPITHLPPNIVFQDYALFPHLNVGRNKGLSSDAIHKRTMELLALVKLQDFA----DRMPDQLSGGQRQRVALMRALAPD----VLLLDEPLSALDAKLRQQMQIELKTIRTTGKTFIFVTHDEEALTMSDVIVVM------NKGRIEQMGGPNELYSRPRSRFVANFIGQSNF....................................................................................................................................................................................................................................................................................................................................................... 240
64 -9.510[P] COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component  ali follow..  22  32.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GGRFDAVAESNLAVAENEFVAIVGPTGCGKSTLLN------------------------VAGLL----------------------------------------------TPASGTVEISGQRLQGLNRKGYLFQQDALMPWKTVLENVAIG---------LEIAGTPKAKAREQA------------------EWLNKVGLGTFGDRYPH-MLSGGQRKRVGLAQVLIRNPK---YLLMDEPFGPLDAQTRVIMGDLLLDLSQDKKAVMFVTHDLEAIALADRVVIMGPRARIMAEYRIPLARPREISEIRLDNQFHEIHREI. 261
65 -9.370[V] COG1131 ABC-type multidrug transport system, ATPase component  ali follow..  26  21.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LKEVNLDIQRGEIFALLGPNGAGKTTLIS---------------------------------VCGIVNRSTGTVT---------------------------------DGHDIGKDYRAARSLIGLVPQELTI----------------------------DAFESVWATVNYSRGLFGKPPNHGFVEKVLRDLSL-WDKKDAKAITLSGGMKRRLMIAKALSHEPR---ILFLDEPTAGVDVELRQDMWEMVRRLREDGVTIILTTHYIEEAEAMADRVGV------NRGEIILVENKAELMH............... 223
66 -9.350[R] COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain  ali follow..  10  874...IITPFVQKNLLNIARACSTRMFPILIQGPTSSGKTSMIFVRINNHEHTDLQEYIGTYVTDDNGSLSFREGVLVEALRNGYWIVLDELNLAPTDVLEALNRLLDDNRMLFATQNPPGVYAGRKHLSRAFRNRFLEIHFDDIPENELETILHKRCKIAPSYAAKIVQVFRELSLRRQTTRIFEQKNSFATLQQLAENGYMLLAERARDQKD-KLAVQEVIEKVMKVKIDTDGIEIFQDMSLKEGPLSKVVWTRPMIRLFCLVWRCLLAKEPVGKTTVCQILAECLHKELHIINAHQDTENGDGAQRPVRNRSAVNYSLHSQLCEKFNVQEKLSSSEKNDNLSNLIERQIIKYRSLFEWH-------------DGALVTAMKQGDFFLLDEISLADDSVLERL-------NSVLELSRTLTLVEHS---NAAVSLTAKDGFAFFATMNPGGDYGKKELSPALRNRTEIWVPPMVDTEDILK-EGKLHNNKIELARPLVEIRDVLSAVEFINACEILDLNLVLFNAVSMVFIDALGSFTTFSLSNNLASLHAERQRCFA---------NELAGSNIMASKSADISIKFSDSSFFIGDFGIPLGDSVESDSTYSLHTDTTLMNASKVLRALQVLKPILLEGSPGVGKTSLI-TALARETGHQLVRINLSDQTDLMDLFGLAAMRNGHWVLLDELNLASQSVLEGLNACLDHRNEAYIPELDKVFKAHPNFRVFAAQNPQHQGGGRKGLPRSFINRFS-VVYVE-------ALKEKDMIEIAA-CNYHQVNEDWRLKIIKFMFRLQDNIEKDISFGSFGLQLLNDAPKYTCVSPADYLEVMVLHRMRTVEDRVRTCELFKEVFDIDYEPRTIGFSLSSQCFKVGHSLLVLESVITCINKKWPCILVGDTATGK----------TCILRLLAAIAGAKIKEM.. 1900
67 -9.250[P] COG4525 ABC-type taurine transport system, ATPase component  ali follow..  28  17.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LQDVSLQIASGQLVVVLGPSGCGKTTL--------------------------------LNLIAGFMTPSAGV--------------------ITLDNIPVSGPSAER----------------GVVFQNEGLLPWRDVVSNVEFGLQLAG--MSKEQRRVTALKMLNR------------------------VGLAGFE-HHFIWQLSGGMRQRVGIARALA---VDPRLLLLDEPFGALDAFTREQMQELLLTIRDTGKQILLITHDIEAVFLASELLLLSPGPG................................ 207

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Li W, Jaroszewski L, Godzik A. Clustering of highly homologous sequences to reduce the size of large protein databases. Bioinformatics. 2001 Mar;17(3):282-3.