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60682029.1-599
Query: gi|60682029|ref|YP_212173.1| putative bifunctional CbiF/CbiG cobalamin biosynthesis protein (BF2549) [Bacteroides fragilis NCTC 9343] (Range: 1-599), from B.fragilis

Results of FFAS03 search in SCOP175
Master-slave alignment does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKTAIIVISEAGIALAKTLEQELPESEIFSTGTDTDCHSISNLQEAVPEIFHKFDAIIFIGAMGICIRAIAPHIEDKHKDPAVVCVDSTGRYAVSVLSGHIGGANGLTRYVASILGAEPVITTRSDRTGLWALDTLGKKYGWQTVPAESSDMNHLITLFVDCKPTALLLDIRDEGTTQLEHTLPPHVDVFYKFEDMDLRKYDLLLLVTPFIYNTSDTPALYYVPPVLHMGVGLARDAHPVDTVITHLMDVVVQANMIPLAIRTVSSIEEKKDEPVLKLLAEAYQTRLYTASQLSKIEVPTPSEVVNKHMGTPSVSEASALLSSGGGPLLLPKQKGANFTVAIAMDAASVRQGHIEIVGAGPGDPELISVRGRHFLEEADLILYAGSLVPRELTECAKAGATIRSSASMTLEEQFALMKEFYDRGQLVVRLHTGDPCIYGAIQEQMNFFDQYGMHYHITPGISSFQAAAAALQSQFTIPERVQTIILTRGEGRTPMPEKEKLSLLARSQSTMCIFLSAGVVDQVQRELLEHYPPTTPVAACYHLTWKDERIFRGQLQDLAKIVNENHLTLTTMIVVGDAIDNREGLSRLYSHQFKHLFRKLast
1 -63.700d1cbfa_ c.90.1.1 (A:) Cobalt precorrin-4 methyltransferase CbiF {Bacillus megaterium [TaxId: 1404]}  ali model 3D-neighbors follow..  44  7.............................................................................................................................................................................................................................................................................................................................................................SHMKLYIIGAGPGDPDLITVKGLKLLQQADVVLYADSLVSQDLIAKSKPGAEVLKTAGMHLEEMVGTMLDRMREGKMVVRVHTGDPAMYGAIMEQMVLLKREGVDIEIVPGVTSVFAAAAAAEAELTIPDLTQTVILTRAEGRTPVPEFEKLTDLAKHKCTIALFLSSTLTKKVMKEFINAWSEDTPVVVVYKATWPDEKIVRTTVKDLDDAMRTNGIRKQAMILAGWALD................... 238
2 -56.200d3eeqa2 c.152.1.1 (A:8-214) Cobalamin biosynthesis protein G, CbiG {Sulfolobus solfataricus [TaxId: 2287]}  ali model 3D-neighbors follow..  20  8RGICIISASEDAFSAGETIKEKLKSFEIPV-------VHYRYKDAEIETIWKCYDAIVFVMALEGATRIVCKYAKSKTEDPAIVCIDDKINYVIPLLGGH-WGANDIARELSVILNSTPIITTAAEIKGKLSIERIANILIAKIINPE--NIVKINAALLRDESICIDGIDV-------NVNFPENI-------KVNSEECSYIISLRGDKEY-KDKIVVWLKP....................................................................................................................................................................................................................................................................................................................................................................................... 206
3 -42.000d1ve2a1 c.90.1.1 (A:1-235) Uroporphyrin-III C-methyltransferase (SUMT, UROM, CobA) {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  24  2..............................................................................................................................................................................................................................................................................................................................................................RGKVYLVGAGFGGPEHLTLKALRVLEVAEVVL-HDRLVHPGVLALAKGEGKEGYGGKTPQEAITARLIALAREGRVVARLKGGDPMVFGRGGEEALALRRAGIPFEVVPGVTSAVGALSALGLPLTHRGLARSFAVATG---------HDPALPLPRADTLVLLMPLHTLGGLKERLLERFPPETPLALLARVGWPGEAVRLGRVEDLPGLG--EGLPSPALLVVGKVVGLYGELLPK........... 231
4 -39.800d1pjqa2 c.90.1.1 (A:216-457) Siroheme synthase CysG, domains 4 and 5 {Salmonella typhimurium [TaxId: 90371]}  ali model 3D-neighbors follow..  23  1...............................................................................................................................................................................................................................................................................................................................................................GEVVLVGAGPGDAGLLTLKGLQQIQQADIVV-YDRLVSDDIMNLVRRDADRVGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCHAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLVTGHLKTGGEL--DWENLAAEKQTLVFYMGLNQAATIQEKLIAFMQADMPVALVENGTSVKQRVVHGVLTQLGELA--QQVESPALIIVGRVVALRDKLNWF........... 239
5 -39.500d2deka1 c.90.1.1 (A:1-265) Diphthine synthase, DphB {Pyrococcus horikoshii [TaxId: 53953]}  ali model 3D-neighbors follow..  15  2................................................................................................................................................................................................................................................................................................................................................................VLYFIGLGLYDERDITVKGLEIAKKCDYVFAYTSLMAGTTLGRIQKGKEIRVLSREDVELNFENIVLPLAKENDVAFLTPGDPLVATTHAELRIRAKRAGVESYVIHAPSIYSAVGITGLHIYKFGKSATVAYPEGNWFPTSYYDVIKLDIKAEKRMYMTANEAMELLLKVEDMKKGGFTDDTLVVVLARAGSLNPTIRAGYVKDLIR--EDFGDPPHILIVPGKLHIVEAEYLVEIAGAPREILRV 263
6 -37.800d2w6ka1 c.151.1.1 (A:1-139) Cobalamin biosynthesis protein CobE {Pseudomonas aeruginosa [TaxId: 287]}  ali model 3D-neighbors follow..  26  3............................................................................................................................................................................................................................LPIPSLLIAGIGCRRGCS-AEHLRALLERTLGEHGRSLAELDALASIDGKRDEPGLRQLATLLERPVLAPAVLHDYEPRSPSAVALRETGCSSVAEAAALALAGRADLLGAKRSDDRASIALARLL............................................................................................................................................................................................................................................................. 136
7 -33.900d3by5a1 c.151.1.1 (A:8-130) Cobalamin biosynthesis protein CobE {Agrobacterium tumefaciens [TaxId: 358]}  ali model 3D-neighbors follow..  28  1.................................................................................................................................................................................................................................VTVAGIGCRKGAA-SDAIIAAVRAAERAFGV---TVDYLATAPLKADEAGLAEAAKGLSLSLVAQERLEAVAAETFSQASLDHSGSPSVSEAAALAAAGGARLVAPRLVVGDVTVAIAMTS............................................................................................................................................................................................................................................................. 122
8 -31.000d2bb3a1 c.90.1.1 (A:1-195) Precorrin-6y methylase CbiE {Archaeoglobus fulgidus [TaxId: 2234]}  ali model 3D-neighbors follow..  20  1................................................................................................................................................................................................................................................................................................................................................................MIWIVGSGTCR-GQTTERAKEIIERAEVIYGSRRAL--ELAGVVDDSRARILRSFKGDE----RRIMEEGREREVAVISTGDPMVAGLGRVLREIAEDV--EIKIEPAISSVQVALARLKVDL-----SEVAVVDCHA-KDFDAELTELLKYRHLLILADSHFPLERL------------GKRRVVLLENLCMEGERIREGNADSI------ELESDYTIIFVEREV.................... 195
9 -31.000d3eeqa1 c.151.1.1 (A:215-335) Cobalamin biosynthesis protein G, CbiG {Sulfolobus solfataricus [TaxId: 2287]}  ali model 3D-neighbors follow..  21  2..................................................................................................................................................................................................................................ISIGIGSKKDVK-MEEIRDGIYKVLERLNLKRERIGIIASIREEVKK-----IADEFNVRFVNEEEINNFMNPTPPSKTLIEVGLKGVAEISALIAGGRNSKLIKIAISRNSTIAVATYE............................................................................................................................................................................................................................................................. 121
10 -30.000d1wdea_ c.90.1.1 (A:) Diphthine synthase, DphB {Aeropyrum pernix [TaxId: 56636]}  ali model 3D-neighbors follow..  15  1.............................................................................................................................................................................................................................................................................................................................................................EAVTLLLVGWGYAP-GMQTLEALDAVRRADVVY-VESYTMPGSSWLYKSEARVVEASRRDLEERSREIVSRALDA-VVAVVTAGDPMVATTHSSLAAEALEAGVAVRYIPGVSGVQAARGATMLSFYRFGGTVTLPGP-WRGVTPISVARRIYLVDERGVQLSPGQGVSLLLEADREYARELARLPSVLVEAGAGGGHRVLYWSSLERLST--ADVEGGVYSIVIPARLSGVEEWLLAAASGQ....... 262
11 -18.700d1wyza1 c.90.1.1 (A:2-234) Putative methytransferase BT4190 {Bacteroides thetaiotaomicron [TaxId: 818]}  ali model 3D-neighbors follow..  12  1..............................................................................................................................................................................................................................................................................................................................................................ETALYLLPVTLGDTPLLPSYNTEIIRGIRHFIVEDVRSARRFLKKVDREIDIDSLTKHTSPEDISGYLKPLAGGASMGVISAGCPAVADPGADVVAIAQRQKLKVIPLVGPSSIILSVMASGFNGQSFAFHGYLPIEPGERAKKLKTLEQ--RVYAESQTQLFIETPYRNHKMIEDILQNCRPQTKLCIAANITCEGEFIQTRTVKDWKGHIPELSKIPCIFLL......................... 231
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Doukhanina EV, Chen S, van der Zalm E, Godzik A, Reed J, Dickman MB. Identification and functional characterization of the BAG protein family inArabidopsis thaliana. Biol Chem. 2006 Jul 7;281(27):18793-801. Epub 2006 Apr 24.