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KOG2711
Query: [C] KOG2711 Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase, from COG0709

Results of FFAS03 search in COG0709
Master-slave alignment does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTVAALNKLSALSGSIQKSFSPKLISVGIIGSGNWGTAIAKICGENAKAHPDIFHPQVHMWMYEEKIQHEGKECNLTEVFNTTHENVKYLKGIKCPSNVFANPDIRDVGSRSDILVWVLPHQFVVRICNQLKGCLKKDAVAISCIKGVSVTKDRVRLFSDIIEENTGMYCGVLSGANIASEVAQEKFCETTIGYLPNSSVNPRYTPKTIQALFNRPYFRVNIVEDVPGVALGGALKNIVAVAAGIIDGLELGDNTKSAVMRIGLLEMQKFGRMFFDCKPLTMSEESCGIADLITTCLGGRNHKCAVAFVKTGKPMHVVEQELLDGQKLQGAATAKEVYEFLDNQNKVSEFPLFTAVYRIVYEGLPPNKLLEAILast
1 -103.000[C] KOG2711 Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase  ali  100  1MTVAALNKLSALSGSIQKSFSPKLISVGIIGSGNWGTAIAKICGENAKAHPDIFHPQVHMWMYEEKIQHEGKECNLTEVFNTTHENVKYLKGIKCPSNVFANPDIRDVGSRSDILVWVLPHQFVVRICNQLKGCLKKDAVAISCIKGVSVTKDRVRLFSDIIEENTGMYCGVLSGANIASEVAQEKFCETTIGYLPNSSVNPRYTPKTIQALFNRPYFRVNIVEDVPGVALGGALKNIVAVAAGIIDGLELGDNTKSAVMRIGLLEMQKFGRMFFDCKPLTMSEESCGIADLITTCLGGRNHKCAVAFVKTGKPMHVVEQELLDGQKLQGAATAKEVYEFLDNQNKVSEFPLFTAVYRIVYEGLPPNKLLEAI 373
2 -80.200[C] COG0240 Glycerol-3-phosphate dehydrogenase  ali follow..  22  1......................MKQHIGYLGMGIWGFCLASLLANKGY--------PVVAWSRNPDL---------IKQLQEERRH-PLAPNVVISPNLSFTTDMKEAIHNAFMIVEGVTSAGIRPVAEQLKQITDLSVPFVITSKGIEQNTGLLLSEIMLEVDSVTPYLGYLSGPSIAKEVLNGSPCSVVVSAYDS------QTLKQIHEAFSLPTFRVYPNTDIKGAALGGALKNVIAIACGIAEGLSFGNNAKAGLVTRGLHEMRKLAAIMDCKPETLNGLAGLGDLCVTCFSESSRNLRFGHLLAQGL---TFEQAKAKIGMVVEGAYTALSAYQVAKHHK--IDMPITTGIYRVLYENLDLKEGIALL 324
3 -28.100[S] COG4408 Uncharacterized protein conserved in bacteria  ali follow..  1.......................MSKLLMIGTGPVAIQLANICYLKSD-------YEIDMVGRASTSEKSKRLYQAYKKFEVKIQNEAHQHLEGKFEINRLYKDVKNVKGEYETVVMACTADAYYDTLQQLSLETLQSVKHVILISPFMSKFSQDIEVISFSTYLGDTRIVDKEAPNHVLTTGVKKKLYMGSTHSNS------TMCQRISALAEQLKIQLEVVESPLHAETRNSVHPPLFMNDFSLKAIFEGTDTLIREMRLMWKEMMAILQAFRVPSVNLLQFMVKENYPVRPETLDENGHYFDFSAVPFKQVYKNEQDVVQIRMPSEDYYRTAMIQHIGKMLG--IKTPMIDQFLTRYEASCQ........ 395
4 -17.900[H] COG1893 Ketopantoate reductase  ali follow..  10  2......................EKPRVAVIGSGSIGLLLYAYLKLANW-----------------PALLVTNRPEQADHLNKEGLTFVAKSGEHQPISVTATPLSSFSAEEAEVGFITVKSFAVKALLPQLQRKKWDG--LVFFQNGMTHLEILRQIPARAICCGIVEIGAKRESDVRVQHTGDGAIWIGDMVGDSKNF-------DPMWACLHNAGLKAQKVTNWQDKMIANAAINPLTGLFRVKNGALIENQLFSLLLKELVKEACVTLGREREVDEHLAYTRAICDKTANNLSSMYMD--------------------LTHHRRTEIESITGYLIKEAAKKG--IEIPNTSFVYHAV............. 295
5 -15.700[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  1...................MSHTKPSIAILGAGRVGSSLARSAVAAGY--------EVKVAGSGAVDKIALTAEILMPGA--------------------VPSTADQAVKDADIVFLAVPLHKFRSVNPATL----EGKIVIDTMNHWVPVNGELEEIDQDPRSTSEIIAEFFAGSTMVKSFDAGTGRAIAYATDDVDAG------AQVAQLIKSFGFVPLNIGAL--LEPGQEAFGAHLNKDSRLELVN........................................................................................................................... 206
6 -12.300[E] COG0345 Pyrroline-5-carboxylate reductase  ali follow..  15  2......................ENQKIGFIGAGKMGSALMQGTIKAGIVTP--------------------------ENIGASDVYEPFLKDLQAKLGIRVSTDNAVIVRESDILILAVKPQTLSSVLSNLKNEITSEKLVISIAAGVPLST--------YEDALLEGTRVVRVMPNIAATVSEAA---SGIAPGKNATPEDLKAALEIFSAVGTAVQVPESLMDAVTGLSGSGPAFIFPVIEAMADG-----------VLEGMDR---------KSALTLAAQTVLGAAKMALETGMHPGELKDMVTSPAGTTIQGIHSLEEAGIRAAFMNAVIRASERSKELGKK.......................... 270
7 -10.700[I] KOG2304 3-hydroxyacyl-CoA dehydrogenase  ali follow..  12  3....SSTCTAAVRGLSTTAQLSKINNVTIIGAGLMGSGIAQVSANAKLNVTVVDSNQSALEKAQQGIANSLKRVAKKKHADDAAAQTALVSSV---DRIKMSTNVSDSVKDADLVIEAIVENI-RKLFAEVEVAAKPTTLITTNTSSLRLADIGLNLKDKSR----------FGGLHFFNPVPMMKLLEVVRHTETSD-----ATFNQLVDYGKTVGKTTVACKDTPGFIVNRLLVPYM--------------FEALRLYERGDASMEDIDVAM................................................................................................... 243
8 -10.700[S] COG5495 Uncharacterized conserved protein  ali follow..  10  7...................LRSARLNIAILSTGRVGVALERADQV---------------------VACSAVSHASRQWVQFR----------------TSVASPPEVASSAELLLLAVPDCEFAGLMSGVAVTSVPRPGTIVA----------------------------TSWANGVGILAQLGKDGCIPLAIHPAMMFSGSDEDLSQCQLRDTYFGITKTDDVGYAIAQSLVLEMGGEPFCVVEYARILYHSVSPHVGNHIVTVLADALEVRRSALRGSELLGLGVPPACRGEVVDDQLDVIVERIVGSLARAACENTLQRGAGLTKLVARGDLDALAGHLVLMRIGPELAQAYRVN............. 289
9 -10.700[E] COG0287 Prephenate dehydrogenase  ali follow..  13  4....................DIMFERIALIGIGLIGSSIARDVRELGLAR------HVVISTRSEDTLKRAEELALGTDY---------------------TVSAAEAVKDADLVIVSVPVGASESVAQQIAPYLKPSAIVT------DVGSTKASVIAQMAPHMPENVHFIPGHPLAGTEKSGPDAGFAIFTPLPGTDAAALERLKDFWRALGSRVDEMDAEHHDKVLAIVSHLPHIIAYNI-VGTADDLETVTEIKYSASGFRDFTRLAAS.................................................................................................... 233
10 -10.500[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  72......................QFTVIDDFAYEDVIEAHKEDPEKIMPQIR------EKVNEVAKELPKPPEGAIHFTHPEDL--------------GFEITTDDREAVADADFIMTWFPKGDMQPIIDKFIDDIKPGAIVTHACTIPTTKFYKIFEEKHGDLVTKPETLNVTSYPGAVPEMKGQ-----VYIAEGYASEEAINTLFELGQKARGNAYRLPAELLGPVCDMCSALTAITYAGISVTQVLGAPAGFAQMMAKESLEQITALMEKVG.................................................................................................. 306
11 -10.400[E] KOG3124 Pyrroline-5-carboxylate reductase  ali follow..  11  1........................MSVGFIGAGQLAYALARGFTAAG----ILSAHKIIASSPEMNLPTVSALRKM---------------------GVNLTRSNKETVKHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPK-----VIRCMTNTPVVVQEG---ATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAYAFMALDALADGMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIHALHFLESGGFRSLLINA--VEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTL................. 300
12 -10.400[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  12  2......................STMKVAVYGAGNGGSRMAIEFAEAGH--------DVVLAEPARDMLDDAHWKVVEDA------------------GVTVTDNDAEAASEAEIAVLFTPGKKTFEIAKNITNHLPEGAVIANTC-TVSPVVLYYVLERELRRDRKDLGIASMH-PAAVPGTPQHGHYVIGGHSSSELDIATDEQISRCVELAESCGKVAYVVPADVSSAVADMGSLVTAVTSGVLDYYYVGTQI...................................................................................................................... 228
13 -10.300[M] COG1004 Predicted UDP-glucose 6-dehydrogenase  ali follow..  11  1........................MKVTVFGIGYVGLVQATVLAEVGHDVLCID------------------DANKVADLKKGRIAAPLVKENYEAGRLQFSTDAQAGVAHGVIQFIAVGTKYVLDVASTIGTYMDSPKVIIDKSTVPVGTADKVHQVIQAILRGEKIDFSVVSNPEFLKE----RPERIVIGIDTDDSGALELISELYEPFNRNHD--RMLVMDIRSAELTKYAANGMATKISFM-------NEIANIAERLGADIEKVRQGIGSDSRIGYHFIYSGCGDIQALIRTAEDKGYKPQLLQAVEQINNQQKYKLTEFIKSHFNSQ-AVWGLAFKPNTD-EAPSRVVMESLWEAGATIQ...... 355
14 -9.370[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  11  1........................MQLGMIGLGRMGANIVRRLAKGGHDCVVY---------------------------DHDPDAVKAMAGEDRTTGVASLRELSQRLSAPRVVWVMVPANITTAVIEELANTLEAGDIVI------DGGNTYYRDDLRHEKLLFKKGIHLLDCGTSGGVWGRERGYCLMIGGDGDAF-------ARAEPIFATVAPGVAAAPRTPGRDGEVAPSEQGYLHCG--CGSGMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAPLP--NPECYQYDFDIPEVAEVWRRGSVIGSWLLDTAIALRESPDLAEFSGRVSDSGEGVPAPVLTTALQSRFASRDLDDFANKA 323
15 -9.130[I] COG1250 3-hydroxyacyl-CoA dehydrogenase  ali follow..  15  1......................MIKTVGIIGAGQMGCGIAHVSAAAGYKVQLYDIAADRIEAGLATINGNLARQVSSGKMSDEDRK-------RALSLIKGSGDIND-LAQADLVIEAVTEDE-RKIYGQVCPVMRPDAILATNTSSLSITRLASATDRPER----------FMGIHFMNPVPVMKLVELVRGIATEE-----ETFKAAKEFVAHLDKTVTVAEDFPAFIVNRILEAIYTLYEGVGTGANHPMGPLQLADFIGLDTCLSIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKSGRG.................................................................... 277

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab

Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Plewczynski D, Tkacz A, Godzik A., Rychlewski L. A support vector machine approach to the identification of phosphorylation sites. Cell Mol Biol Lett. 2005;10(1):73-89.