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KOG2004
Query: [O] KOG2004 Mitochondrial ATP-dependent protease PIM1/LON, from COG0709

Results of FFAS03 search in COG0709
Master-slave alignment does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MYRAGAVLLRGATRTRLLAAASAHQSFATFSQRNQSILMMKSMELAGNSGERRFYSTHDDPIAVDDSLELYKDLGGMSPIQVPADMPNVPMLAINRYPLFPGFIKKVDIVKDDNLKALIRRQLSLKQPYAGVFVKRDDENKEETITSLSEVYPTGSFVQIIEVRDQGSVLELVLSAHRRIRALEPIDEITPKNETPLNGRRARGKRAASATSPLTPPPSPPPLAPSVASVAPEISATEEKEEKTTPPSATGEKQKKGIIMVRTENVVAEPVPKNNETKATMMAIVQTIRDVVQFNQLFGQQINLLLHPSQNVIDNPVYLCDLVATLVQSAETKDLQEMMDEIDVSKRLKIALLLIQKEKAVAKLKYDINKDVEKKVQDHHRKYLLNEQLKVIKKELGIEKDEKTTIIEKIDERIKTLAVPEYALKVINEEKTKLQFLDPHSSEFSVTRNYLEWLTSVPWGLTSPENRRLSVAKKALDEGHYGMKDVKERIMEFIAVNLLRKSIGGKILCFHGPPGVGKTSIAKSIATALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKMIQCMKKVKTENPLVLIDEVDKIGGAGFHGDPASALLELLDPEQNANFNDHFLDVPVDLSRVLFICTANEISKIPGPLRDRMEMIDVSGYLAEEKVEIAHQHLIPQLRKDTSLATEQLKIEDSALEELIKHYCRESGVRNLQQHIERIFRKAALQIAEQQNEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAEQIVVCTENLQKFVGRPKFTSDRMYEVTPPGVIMGLAWTAMGGSALYIETVLKRPVDLTNDKDGSIETTGNLGDVMKESVRTALTVAKGILAREQPDNKFFDKAHIHIHVPEGATPKDGPSAGVTLVSSLLSLALDRPVVQDMAMTGEISLTGKVLPVGGIREKVIAARRVGAKRVFLPNENRRDFDDLPEFMKSELDIRFVSHYDELYEHLFQLast
1 -211.000[O] KOG2004 Mitochondrial ATP-dependent protease PIM1/LON  ali  100  1MYRAGAVLLRGATRTRLLAAASAHQSFATFSQRNQSILMMKSMELAGNSGERRFYSTHDDPIAVDDSLELYKDLGGMSPIQVPADMPNVPMLAINRYPLFPGFIKKVDIVKDDNLKALIRRQLSLKQPYAGVFVKRDDENKEETITSLSEVYPTGSFVQIIEVRDQGSVLELVLSAHRRIRALEPIDEITPKNETPLNGRRARGKRAASATSPLTPPPSPPPLAPSVASVAPEISATEEKEEKTTPPSATGEKQKKGIIMVRTENVVAEPVPKNNETKATMMAIVQTIRDVVQFNQLFGQQINLLLHPSQNVIDNPVYLCDLVATLVQSAETKDLQEMMDEIDVSKRLKIALLLIQKEKAVAKLKYDINKDVEKKVQDHHRKYLLNEQLKVIKKELGIEKDEKTTIIEKIDERIKTLAVPEYALKVINEEKTKLQFLDPHSSEFSVTRNYLEWLTSVPWGLTSPENRRLSVAKKALDEGHYGMKDVKERIMEFIAVNLLRKSIGGKILCFHGPPGVGKTSIAKSIATALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKMIQCMKKVKTENPLVLIDEVDKIGGAGFHGDPASALLELLDPEQNANFNDHFLDVPVDLSRVLFICTANEISKIPGPLRDRMEMIDVSGYLAEEKVEIAHQHLIPQLRKDTSLATEQLKIEDSALEELIKHYCRESGVRNLQQHIERIFRKAALQIAEQQNEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAEQIVVCTENLQKFVGRPKFTSDRMYEVTPPGVIMGLAWTAMGGSALYIETVLKRPVDLTNDKDGSIETTGNLGDVMKESVRTALTVAKGILAREQPDNKFFDKAHIHIHVPEGATPKDGPSAGVTLVSSLLSLALDRPVVQDMAMTGEISLTGKVLPVGGIREKVIAARRVGAKRVFLPNENRRDFDDLPEFMKSELDIRFVSHYDELYEHLFQ 971
2 -162.000[O] COG0466 ATP-dependent Lon protease, bacterial type  ali follow..  37  2..............................................................................YTEQAENNRESLIMPLFEVVVYPKGRAKFLADKVTGEILLAEMKTTEAVYAVGLTVKSGTKPSE---ISEDSLYKTGNLLKIGYVQPADDG-------------------------------------------------------------------YLVIAKAVQKVEAVSVYRKNGLFYAMFKPVFDIP-DLDEDIQAEMMANIKKAIREISSRFQGSEQFTKPI----EKMDSIDQLIGYVMPYMP-IKLEEKQALLEIVSVRERYFAFFEILMKQKENINFQMEMAKKVTDKISKSNREAMLREQLKMIQEELN-GGDDAASGEGGYRERIEKSTMPEEVKKKALSELKKLETGGPHNPESSVIRNYLDLMLDLPWVTEEKKSIDIDEARRVLESNHNGLEKVKERIIQHLAVMKLKKEKQGSILLLTGPPGTGKTSLGKSIADALGREYVRISLGGVRDEAEIRGHRRTYIGALPGRIIQGMRKAGTKNPVFILDEVDKLSTS-YAGDPASALLEVLDPEQNNTFSDHYLEVPYDLSEVFFIATANSLASIPWPLLDRMETIEISGYTKNEKLAIAKDHLLPCILEEHGLDADKLKIEDEALKGIIDKYTREAGVRGLKKQLARTARFVSEKIVSGK----------------------------------TDLPYVVRADMLKEVLGKEIIRQEEARKENVPGVVTGLAWTPVGGDILFIEGTFM-------PGNGKLTLTGQLGDVMKESAQISLSLVRSRLASTENSFN-FTASDVHIHVPSGATPKDGPSAGVTLFTALTSLITGKAVDPKLAMTGEITLSGAVLPVGGIKEKVLAAHRAGIKKVILPKENERDLEDVPEEVRNELKFVPVETIEEVLKEALG 774
3 -82.400[O] COG4930 Predicted ATP-dependent Lon-type protease  ali follow..  12  1...................................................................................................................................................................................................................................................................................................MQTHHDLP-VPAVSEGELVAEGYDLDALLNQHFRGR-VVRKDLTKQLKEGANVPVYV---LEYLLGMYCASDDDQIVEQGLQNVKRILADNYVRPDEAEKVKSLIRERGSYKNQKKDVYEAQLSNLGIKDALVPPQMVKDNEKLLTGGIWCMITVNYFFEEGQKTSPFQMPNMDMEEVFTARTHFNRDQWIDVLLRQRTKWHLITRMIPFVENNYNVCELGPRGTGKSHVYKECS-----PNSLLVSGGQTTVANLFYNMASRQIGLVGMWDVVAFDEVAGITFKDKDGVQIM-KDYMASGSFSRGRDSIEGKASMVFVGNI-----NQSVETLVKTSHLLAPFPAAMIDTAFFDRFHAYIPGWEIPKMRPEFFTNRYGLITLAEYMREMRKRSFSDAIDKFYKLGNNLNQRRRTVSGLLKLLHPNGSYSKEDVRVCLTYAMEARRRVKEQLKKLGGLEFFDVNFSYIDNETLEEFFVSVPEQGGSELIPAGMPKPGVVHLVTQAESGMTGLYRFETQM------TAGNGKHSVSGLSSTSAKEAIRVGFDYFKGNLSRVSATAK-FSEHEYHLHVVELHNTGPSTATSLAALIALCSVLLAKPVQEQMVVLGSMTLGGVINPVQDLAASLQLAFDSGAKKVLLPMSSAVDIPTVPAELFTKFQVSFYSEPVDAVYKALG 692
4 -61.600[O] COG1067 Predicted ATP-dependent protease  ali follow..  12  16.......................................................................................KLEKLECKSTKELA--PIDEIVGQERAQKAVEFAMSIKEKGY--------------------NIYAIGRNGL---------------------------------------GKRTMILRYLSRHQHDVNKLYDWCYVANFEDLKLPCGIGIQFRQDIEKLMTKLVTAIPLAF---------DNEIYFSRAEKLKNQLAQKQESELE-------------------------------------SITRTAKERGVSLTLTPQGEYQFVALNGEEMHTEETFDALSKREQEQFSNTIDELEVSLRNMVRQLT----EWEESYSEKIKKLNDEVTLDVIAHFIKKLKLDYSKYPEIKAYLTELQKDIVENVEIFLDEGADQGELANASLDKKMPRRYKVNVLVSRNAEEFPIVVEESPNYHSLFTYKGTVFTDFSLIRPGSLHKANGGVLLMDAVKVLEQPYVWDGLKRALRSRQLSFTSLEKEVTLTGTVSLDPEPIPLDVK---GDYRTELLAHYDPEFSELFRDFADEMPRDADSELHYAISSIVHDANMLHCDRKAIARIIEHSSRTTGDQTKLSLHSAHIA--NLLRESNYVAKQANANLIRQIHVEEALRNQELRVNRLQQSMMETFVNG----------------------------------------TTLIQTEGVAIGQVNALSVLATSDHAFGMPNRITATTSYGEGEIIDIERNVDLGGSIHSKGVMILSAYLSSVFGRTARIPLT--------------------TTITFEQSYGGVDGDSASMAEFCAIVSAFSKQPNRQDIAITGSMNQFGESQPIGGLNEKIEGFFRKDTQGVIIPRSNMHNLMLRADVVKGEFHIWAIDHVTEAIEIFTG 756
5 -45.600[O] COG1066 Predicted ATP-dependent serine protease  ali follow..  13  32........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NTISEVRLVSSSNSAKGDRFSGYAGETRAKIQTLAEISLQETPRFSRVLGGGVVPGSAILIGGHPGAGKSTLLLQVMCGLAQN-MTALYVTGEESLQQVAMRAKRLGLPTDKLNMLSEVEQICQLADQLKPQIIVIDSIQVMSSPGSVAQVRECASFLTRYAKTRQVAIIMVGHVTKDGTLAGPKVLEHCIDCSILLEGEADSRYRTLRSHKNRFG-----------------------------------AVNELGVFGMTEQGLREVKNPSAIFLSRGEEQTPGSSVMVIWEGTRPLLVEIQAL-------VDHSMLANPRRVAVGLEQNRLALLLAVLHRHGGLQ-----MSDQDVFVNVV-GGVKVTETSADLALLLALISSFRNRPLPQDLVVFGEVGLAGEIRPVPSGQERIGEAAKHGFKRAIVPFANR------PKSAVPNMDVFTVKKLSDALAILEN 458
6 -36.800[R] COG1750 Archaeal serine proteases  ali follow..  22  2......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KSALKILALMLILITPAG---AQFENAQKASIKAVAVTSGDGVVINISVIVT-------PGDGRVFVTTPYTEIMQGSAQLAAITACDLLGI------DFTKYDFFYIIEAEAPIVGGPSAGGVLTVATVAALKNLTIRDDVYMTGMIYPDGYIGPVGGLKYKLEAAAKNGAKIFLIPQGQRITYVEEKKVRRVGIISYIEVEYKELDLVEY. 202
7 -36.300[T] COG3480 Predicted secreted protein containing a PDZ domain  ali follow..  14  10....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAVTVGVQHATLAHMIYAWLTPFTDIRSAQET------TGGSSDVEFMRINQFYMQTSQNMAKYQG-----------------------------------KTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTFDSSKDLIDYV-------SSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSLAIYTQIAHPDLRNGVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNNYQTALEAAKTIKTDMKIVPVKTLQDAIDYLKN 343
8 -23.900[R] COG2802 Uncharacterized protein, similar to the N-terminal domain of Lon protease  ali follow..  9........................................................................HVGNARYVKNDDLPKTVPVFPLPGALLLPEGHLPLNIFEPRYLAMIDTAL--ASHRLIGMVQPALHVIEAG--IEGGPLSAVGCLGRITSFSET------------------------------------------------------------------GDGRYVISLTGVCRFRLLEEVAGSEPYRSFRHAPFIA--DLSGEYDEEAVDRENLLRVFRAFLDANQLEADWESVE----RAGNRVLVNSLSMMSP-FGPAEKQALLEAPDLKTRAETLIAITEIVLAQGSGEGGTVLQ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 230
9 -16.800[O] KOG0737 AAA+-type ATPase  ali follow..  11  184...................................................................................................................................................................................................................................................................................DERLFLQSLYKVLVSISETNPII--------------LRDVEKLCQ------SERFYKLFQRLLTKLSGPVLVLGSR-LLEPEDDCQEVGEGISALFPYNIEDENQLMSWKTRFEDDMKVIQFQDNKNHIAEVLAANDLECDDLGSICHADTMFLSSHIEEIVVSAISYHLMNNKEPEYKN---EVAPDNEFEKRIRPEVIPADIGSLDETKESLQELVMLPLRRPDLRG--ILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSK---------WFGEDEKNVRALFTLAAKVSPIIFVDEVDSMLGQRTRVGEHEAFMTHWDGLMSNA------------DRILVLAATNRPFDLDEAIIRRFE-IMVGLPSVESREKILRTLLSKEKTENLDFQE--AQMTDGYSGSDLKNFCTTAAYRPVRELIKQECLKDQERRKREEAEKN---------------SEEGSEAKEEVSEERGITLRPLSMEDMKVAKS----QVAASFAAEGAGMNELKQWNDLYGE.......................................................................................................................................................................... 713
10 -16.300[O] COG0542 ATPases with chaperone activity, ATP-binding subunit  ali follow..  16  180............................................................................................................IGRDEEIRRAIQVLQRRTKN---VLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKNKRVLSLDMGALIAGAKYRGEFEERLKAVLNELSKEEGRVILFIDEIHTMVGAGKTDGAMDAGNLLKPSLARGELHCV--ATTLDEYRQYIEKDAALERRFQKVFVGEPTVEDTI-AILRGLKERYEQITDPAIVAAATLSHRYVSDRQLPDKAIDLIDEAASSIRMEIDSKPQPLDRLERRIIQLKLEQQALQKEDDDASRKREKEREYAELEDVWKAEKAALSGTQHIKAELDSQARRASDFAKMSELQYGVIPALEKQLAQAESAEGKEMTLLRYRVTDEEIAEVLSRATGIPVAKMMEGEKELLRMEEELHKRVIGQHEAIEAVSN--AIRRSRAGLSDPSFLFLGPTGVGKTELCKTLANFLENAMVRIDMSEFMEKSRLVGAPPGYVGYEEG-----LTEAVRRRPVILLDEVEKAHH-----DVFNILLQVLD---DGRLTDGQ---TVDFRNTVVIMTSNL-QHFRPEFINRIETVVFHPLGKENIREIATIQLLIKRMESHGYQ---LHFTDACLDFIGEVYDPVYGARPLKRAIQQIENPLAQQILSGK.......................................................................................................................................................................................................................................................... 835
11 -16.200[O] KOG0740 AAA+-type ATPase  ali follow..  18  308...................................................................................................................................................................................................................................................................................................................................................................KKYHQPQRASGSSYGGVKKSLGASRSRGILGKFVPPIPKQDGGEQNGGMQCKPYGAGPTEPAHPVDERLKNLEPKMIE-----------LIMNEIMDHGPPVNW------------------EDIAGVEFAKATIKEIVVWTGLRGPPKG--ILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSK---------WVGEGEKMVRALFAVARCQQPVIFIDEIDSLLSQRGDGEHESSFLVQLDGATTSS------------DRILVVGATNRPQEIDEAARRRLV-LYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIQQSDAFSGADMTQLCRGASLGPIRSLQTA....................................................................................................................................................................................................................................................................... 626
12 -16.100[L] KOG1968 Replication factor C, subunit RFC1 (large subunit)  ali follow..  11  247.................................................................................................................................................................................................................................................................................................................................VITGILETLTRQEATDLIKQYG------KVTGAPSVRTDFILLGENAGPRKVETIKQHKIPAINEDGLFYLITHLPASGGTGAAAQAAQQKKEQEEKKILETVARMDDSNKK-----ESQPSQIWTSKY-------P-----------TSLKDIC-----GNKGVVQKLQKWLQ-PGPDGLGLYKAVLLSGPPGIGKTTAAHLVAKLEGYDVLELNASDTRSKRLLDEQLFGVTDS---QSLAGYFGTKANPVVLIMDEIDGMSSGDRGG--VGQLNMIIKKSMI----------------PIICICNDRAHPKLRPLDRTTFDLRFRRPDANSMRSRIMS-----------AYREGLKLSPQAVDQLVQ--GTQSDMRQIINLLSTY...................................................................................................................................................................................................................................................................... 587
13 -15.900[O] COG0464 ATPases of the AAA+ class  ali follow..  16  201..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................AMEIISEQNIPTVMYEDLGGLKDAISKVREMIELPLKHPELFDRLVLLQGPPGTGKTMLAKAVANESDAYFISINGPEIMSK---------YYGESERAIREIFEDAEKNAPIIFLDEIDSIAPKRAEVTVVAQLLSLMDGLKAR-------------KNVIVIGATNRPEALDIALR---REIELRVPDTEGRLEIFQIHTRGMPLADNVNLMDFAQITYGFVGADIAALCREAAMSALRRILPKINLNEPEISKEILDALQVTREDFENALKDVQPSAIREILIEVNVSWEDVGGLERVKELLKEVVEWPLKNPESYRDEAPKGV---LLYGPPGGKTLLAKAIAHESDANFITAKGSDLLSKWYGE-SEKRIAEVFTRARQVAPSI----------ELDSLAPIRGTSVGEPQVTARILNQLLSEMDGLEELRAVVVIGATNRPDIIDP---------ALLRPG-ELILVPVPDEGARREIFRVHTKNMALAEDVDIEKLVSFT.. 690
14 -15.500[O] KOG0733 Nuclear AAA ATPase (VCP subfamily)  ali follow..  11  6................................................................................................................................................................................................................................................................................................................................TSLSRDLERKIHERLVSLKDTIQQTEIEEWPVSTRRAIQFVQERDMSLRRIKKPILEDTLKAEVEEKLASSQDLVLVDSDMEEQSDSNLMEVKDTNKSITSLWSSPNLKEIDGDEKKSVGQESITGSAKRKDRRSKTNGSKRQKAEANREPPSDISLSDIGGLDDCINELLELVAMPIKHPEVYQYTVLLHGPPGCGKTMLANALANELGVPFISISAPSIVSG---------MSGESEKKVREVFEEAKSLAPLMFIDEIDAVTRESAQREMERRIVAQF------TCMDELSFEKTDGKPVLVIGATNRPDSLDSALRGRFDEICLTVPSQDAREKILRTMAKGLKLSGDFDFRQLAKQTPGYVGADLKALTAAAGIIAIKRIFNEISPLNKLDLNSDPRFNELDSDMALDSNDSLPLDHSSIIQRYLNAHPDPLSPEELEPLAICQDFIEALAKVQPSSKREGFATVPGVSWNNIGALKSIRVELQMAIVQPGPPGCGKTLLAKAVAELLNKYVGESERAVRQVFLRARASSPCV----IFFDELDAMVPRRDDSLS-RVVNTLLTELDGLSDRSGVYVIAATNRPDIIDP---------AMLRPG-KTLLVDLPDAHERVEILKTLTKQTPLHEEVNLDVL...... 687
15 -15.500[O] KOG0741 AAA+-type ATPase  ali follow..  14  222.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GLDKEFSDIFRRAFAFRVFIHVKG--ILLYGPPGCGKTLLARQIGKMLNAREPKVVNG-----PEILNK---YVGESEANIRKLFADAEEEQRIIIFDEIDAIGSTGVHDTVVNQLLSKIDGVEQ-------------LNNILVIGMTNRPDLIDEALLGRLEVMEIGLPDEKGRLQILHIHT--ARMRGHQLLSADVDIKELAVET-LEGLVRAAQSTAMNRHIKAS-TKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSV---LLEGPPHGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSC-----VVDDIERLLDYVPI-----GPRFSNLVLQALLVLLKKAPPQGRIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGERTTIAQQVKGKKVWIGIKKLLMLIEMSLQ 719
16 -15.500[O] KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain  ali follow..  12  454.........................................................................................................................................................................................................................................STALAQTFNMARRYSPTILLLRHFDVFKNLGSQDGSLGDRVGVSFEIASVIRELTEPVSNGDSSMEEKSNSNFSENEVGKFRGHQVLLIASAE-TIRRCFSHEIRMGSLNDEQRSE----MLSQSLQGVSQFLNISSDEFMKGLVGQTSGFLPRDLQALVAD---------AGANLYISQESETKKINSLSDDLHGVDIHQASQIDNSTEKLTAKEDFTKALD---KKRNASALGAPKVPNVKWDDVGGLEDVKTSILDTVQLPLLHKDLSG--VLLYGPPGTGKTLLAKAVATECSLNF--LSVKG----PEL----NMYIGESEKNVRDIFEKARSARPVIFFDELDSLAPARGASGDSSQMLAEID------------GLSDSSQDLFIIGASNRPDLIDPALLDKLLYVGVNA-DASYRERVLKALTRKFKLSEDSLYSVAKKCPSTFTGADMYALCADAWFQAAKRKVSKSDSGDMPTEEDDPDSVVVEYVDFIKAMDQLSPSLSITE................................................................................................................................................................................................................................. 957
17 -15.100[O] KOG0730 AAA+-type ATPase  ali follow..  12  1...............................................................................................................................................................................................................................MGNHRAYKIPSSAPLRSHSSSSPIDLSRNKFPNFLLKTKKDFSTAILERKKSPNRLVVDEAINDDNSVVSLHPTTMEKLQLFRGDTILIKGKKRKDTTCEEPKIRMNKVVRSNLRVRLGDVISVHQCPDVKYGKRVHILPVDDTVEGVTGNLFDAYLKPYFL-EAYRPVRKGDLFLVRGGMRSVEFKVIETDPAEYCVVAPDTEIFCEGEPVKREDEERLDEVGYDDVG-----------------------------GVRKQMAQIRELVELPLRHPQLFKSIILLYGPPGSGKTLIARAVANETGAFFFCINGPEIMSK---------LAGESESNLRKAFEEAEKNAPIIFIDEIDSIAPKREKTNIVSQLLTLMDGLK-------------SRAHVIVMGATNRPNSIDPALR-RFDEIDIGVPDEIGRLEVLRIHTKNMKLAEDVDLERISKDTHGYVGADLAALCTEAALQCIREKMDVILEDDSIDAEILNSMAVSNEHFHTALGNSNPSALRETVVEVPNVSWEDIGGLENVKRELQETVQYPVEHPEKFEKFGMSPSKGVLFYGPPGGKTLLAKAIANECQANFISVKGPELLTMWFGES-EANVREIFDKARQSAPCV-----FFDELDS-IATQRGNSAGDAGGAADRVLNQLLTEMDGMNAKKTVFIIGATNRPDII-------DSALLRPGRLDQLIYIPLPDEDSRLNIFKACLRKSPVAKDVDVTALAKYT.. 715
18 -14.800[O] KOG0739 AAA+-type ATPase  ali follow..  14  1...............................................................................................................................................................................................................................................................................................................................................................................MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCVQYLDRAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQNDVAGLEGAKEALKEAVILTGKRTPWRG--ILLFGPPGTGKSYLAKAVATEANNTFFSVSSSDLMSK---------WLGESEKLVKNLFELARQHKPIIFIDEVDSLCGSRNENEIKTEFLVQMQGVGNNN------------DGTLVLGATNIPWVLDSAIRRRFE-IYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELRKTEGYSGADISIIVRDSLMQPVRKVQSAT----HFKKVCGPSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSLA....................................................................................................................................................................................................... 412
19 -14.800[F] COG1618 Predicted nucleotide kinase  ali follow..  18  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MRIEGKEKTMLRIAVTGSPGVGKSTVVAKTAEKLAEKP-GFKIGGIRTAEIRKEGHREGFSIRDERIGANAVRNALACDLVVIDEIGPMELISQS---VSAVEEVLESDKPHHSSRHPLAQRFRKGFEVLTVDKGNRDELPEKITNRFL....................................................................................................................................................................................................................................................................................................................................... 180
20 -14.800[O] KOG1051 Chaperone HSP104 and related ATP-dependent Clp proteases  ali follow..  13  183...........................................................................................................VIGREDEIRRTIRVLSRRTKN---VLIGEPGVGKTSIAEGLARRIIDDDVPANLSNCKLLSLDVGSLVAGSKFR-----EERIKSVLKEVEESETPIILFVDEMHLLMGAGSGGEGGMDAANLLKP-----MLARGKLHCEYKKYIEKDAAFERRFQIILVKEPSIEDTI-SILRGLKEKYEVHHGV--TISDRALVTAAHLASRYLTSRRLPDSAIDLVDEAAAAVRVTRESQPEVLDNLERKLRQLRVEIRALEREKDEASAARKEAEQVEEETRPIREKYELEKSRGSELQDAKRRLDELKAKAEDAERRNDFTLAADLKYYGIPDLQKRIEYLEQINEIVARWTGIPVTRLKTTEKELLNMEKVLSKQVIGQNEAVTAVAN--AIRLSRAGLSDPSFLFCGPSGTGKTLLTKALASFMENAMIRIDMSEYMEKSRLIGAPPGYVGHEAG-----LTEQLRRRPVILFDEIEKAAP-----EVLTVLLQVLD---DGRITSGQ---VVDAKNAVIIMTSNL-GFFRPEFLNRISIVIFNRLRRVDIRNIVENRILEVQKRLQSNHRSKIEVSDEAKDLLGSAYSPAYGARPLNRVIQNVLNPMAVLILNGQ.......................................................................................................................................................................................................................................................... 858
21 -14.700[R] COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain  ali follow..  12  630................................................................................................................................................................................................................................GALVKAVRSGH---VLLDEINLASIGQLLSSYESGILLSERGDITPITPHKNFRLFGCMNPSTDVGKRELEPSFRSRTEIYVHSPDQNLDDLLSIIQKYIGSLCIGNEHVIREVAELYQVAKSLSLDGSLVDGAGQRPHYTVRTLSRTLSYVTEIAP---IYGLRRSLYEGFCMSFLTLLDHTSELYNHVVRFTLGELNRDQQNAILKQIPKVPDHSSYIAFCHYWLR-----------------RGSFPVEEQEHYIITPFVQK--NLLNIARACSTRMFPIL-IQGPTSSGKTSMIEYVAKKTGHKFVRINNHEHTDLQEYIGTYVT-LSFREGVLVEALRNGY----WIVLDELNLAPTD------LEALNRLLDPETQVLVKPH--------PEFMLFATQNPRKHLSRAFRNRFLEIHFDDIPENELETILHK---------------RCKIAPSYAAKIVQ-------FRELSLRLRDLFRWAFREAVGYQQLAENGYMLLAERARDQKDKLAVQEVIEKVMKVKIDTDGIYNLDSMEIFQDMSLKEGPLSKVVWTRPMIR-WRCLLAKEPVLLV----------GDTGCGKTTVCQILAECLKELHIINAHQDTENGDIIGAQRPVRNRSAVNYSLHSQLCEKFNVQESLDSIDDLIEKSEKNDNLSNLIERQIIKYRSLFEWHDG---ALVTAMKQG-DFFLLDEISLAD-DSVLERLNSVLELSRTLTLVE....... 1343
22 -14.600[LD] KOG2227 Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase  ali follow..  12  3............................................................................................................................................................................................................................................................................................................................................................................TNAGTSLSSYKHIVAIGTTVKSESLESAAYEIPRKRKMRSDS-AAVSGNSVSTPKKLKSHLPSSVPNPGMSEKEVVEDSNEILRYPVNLAVSDCLGTKSKDEEQMRAVKEALHVSK-CREDEQIRIFEFV--KGCIDQQKAGSLYICGCPGTGKSLSMEKVVQQVGDWSTQAGLPPVD--LSVNCTSLSKTTDIFSKILGEIKPGKNANTLIIADEMDYLITKD-----RGVLYDLFMLTTLPF------------SRCILIGVANAID-LADRFLPKLMVITFRAYSKDQILRILQERL----------VLSYVAFQPKALELCARKVAAASG-----RKALCVCRSALEIL-----------------------EIETRGSTGPESQGPTPDDSVVRMDHMAAAL-------SKTFKSPVVETIQSLP---------QHQQIIICAAAKAFRGSKKDATVGELNKLYLEICKSWMISPAGITEFTNMCTVLNDQGILKVG-------RRDKLKRVSLRVDITFALQVNSLFILF....................................................................... 503
23 -14.500[R] COG1223 Predicted ATPase (AAA+ superfamily)  ali follow..  16  84........................................................................................................................................................................................................................................................................................................................................................................................................................................................................IILVESDPRVIETEIVRDITLDDVVGQEEAKRKAKVILEYLRNPEKFGKWAVLFYGPPGTGKTMMAKALSNEAKTPFLSVKSTKLIG---------EHVGDGARRVHELYERARQLAPIVFLDEFDAIALDRGYQEIVNALLTELDGTNSN-------------EGICTIAATNRVELLDASIRSRFE-IEFRLPSYEERLEILRRNLEEFPVPVKGFSGRDLVVIKASLHKAIAEGKDKIETEDLLTAAEKVKMPSRQP............................................................................................................................................................................................................................................................... 346
24 -14.100[L] KOG1514 Origin recognition complex, subunit 1, and related proteins  ali follow..  14  270..........................................................................................................................................................................................................................................................................................................................................................................KCPKEFSKASNDGDDVFLCEYEYDVHWGSFKRVAELADGDEDSDQEWNGRKEEEIDYSDEDDEESVRGVSKSKRGGANSRKGRFFGLEKVGMKRIPEHVRCHKQSELEKAKATLLLAT-CRSKEMEEITAFIKGSISDDQCLGRCMYIHGVPGTGKTISVLSVMKNLKAEVEAGSVSPYC--VEINGLKLASPENIYSVIYEGLSGHRVGWKILLIDELDVLVTRN-----QSVLYNILDWPTKPN------------SKLVVLGIANTMDKLLPRISSRMGILCFGPYNHRQLQEIISTRL-----------EGINAFEKTAIEFASRKVAAISG-----RRALEICRRAA-----------------------------EVADYRLKKSNISAKSQLVIMADVEVAI-------QEMFQAPHIQVMKSVSKLSR----IFLTAMVHELYKTGMA---------SFDRVATTVSSICLTNGEAFPGW----------------------------------DILLKIG------CDLGECRIVLCEPG----HRLQKLQLNFPSDDVAFAL---KDNKDLPWLANYL..................... 771
25 -13.800[O] KOG0726 26S proteasome regulatory complex, ATPase RPT2  ali follow..  16  63......................................................................................................................................................................................................................................................................................................................................................................................KLERIKDYLMMEDEFIRNQERLKPQDEKNEEERSKVDDLRGTPMSVGNLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDQLEP---DPMVTVMKLEKAPQETYADIGGLDTQIQEIKESVELPLTHPEYYEEMVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQK---------YLGDGPKLVRELFRVAEEHAPIVFIDEIDAVGTKRYDSNSGG------EREIQRTMLELLNQLD-SRGDVKVIMATNRIETLDPALIDRK--IEFPLPDEKTKRRIFTIHTSRMTLAEDVNLSELIMAKDDLSGADIKAICTEAGLMALRERRMKVFKKSKESVLYRKKEGT...................................................................................................................................................................................................................................................... 433
26 -13.600[O] KOG0652 26S proteasome regulatory complex, ATPase RPT5  ali follow..  14  21.......................................................................................................................................................................................................................................................................................................................STEDITRATRLLDNEIRILKEDAQRTNLECDSYKEK-------IKENQEKIKLNKQLPYLVGNIVEILEMNPEDDAEEDGANIDLDSQRKGKCVVLKTSTRQTIFLPVVGLVDPDSLKPGDLVGVNKDSYLILDTLPSEYDSRVKA---------MEVDEKPTEDYNDIGGLEKQIQELVEAIVLPMTHKERFEKLVLLYGPPGTGKTLMARACAAQTNATFLKLAGPQLVQM---------FIGDGAKLVRDAFQLAKEKAPIIFIDEIDAIGTKRFDSEVSG------DREVQRTMLELLNQLD-SDERIKVIAATNRADILDPALMDRK--IEFPHPTEEARARILQIHSRKMNVHPDVNFEELARSTDDFNGAQLKAVCVEAGMLALRRDATEVNHEDFNEGIIQ........................................................................................................................................................................................................................................................... 411
27 -13.600[O] KOG0731 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  15  299........................................................................................................................................................................................................................................................................................................................................................................................................................................................................FNIGKATITRADKHSKNKIYFKDVAGCDEAKQEFVHFLKNPKKYEDLGAKIALLVGPPGTGKTLLAKATAGESGVPF--LSISG-SDFMEM------FVGVGPSRVRHLFQEARQAAPIIFIDEIDAIGRARGRGGLGG------NDERESTLNQLLVEMD---AGVVVLAGTNRPDILDKALLDRQITIDKP--DIKGRDQIFKIYLKKIKL------DHEPSYYSQRLAALTPGFA--ADIANVCNEAALIAARHEGATVTMAHFE------------SAIDRVIGGLEKKNRVISKLERRTVAYHESGHAVVGWFLEHAEPLLKVTIV--ALGFAQYVPNENLLMTKEQLFDMTCMTLGGRAAEQVTGAQND-LEKVTKMTYAQVAVY----------------------GFSDKVGL---LSFPPRDDGYDFSKPYSNKTGAIIDEEVR-----------DWVAKAYERTVELV--EEHKVKVAEIAELLLEK-EVLHQDDLLKILG.... 756
28 -13.500[O] KOG4159 Predicted E3 ubiquitin ligase  ali follow..  92...........................................................................................................................................................................TMAYPTVPCPLHVFEPRYRLMIRRSIQTGTKQFGMCVSDTQ------NSFADYGCMLQIRNPDGRSVVDTVGGKRFRVLKRGMKDGYCTADIEYLEDVKVENEDEIKNLRELHDLVYSQACSWFQNLRDRFRSQILQHLQAAPNGPAWCWWLLAVLP-VDPRYQLSVLSMKSLKERLTKIQHILTYFSRDQS................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 290
29 -13.500[O] COG0465 ATP-dependent Zn proteases  ali follow..  16  136.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................KSKARMLTEDQIKTSFADVAGCDEAKEELVDYLREPSRFQKLGGKIVLMVGPPGTGKTLLAKAIAGEAKVPFFTIS----SDFVEM------FVGVGASRVRDMFEQAKKAAPIIFIDEIDAVGRQRGAGLGGG------HDEREQTLNQMLVEMD---EGIIVIAATNRPDVLDPALLDRQVVVGLPDVRGREQI--MRRVPLDTDIDASVIARGTPGFSGADLANLVNEAALFAARGNKRVVSMVEFEKAKDKIMMGAERRSMVMTE-AQKESTAYHEAGHAIIGRLVPEHDPVHKVTIIPRG--RALGVTFFLPEGDAISASRQKLESQISTLYGGRL--AEEIIY--------GPEKVS-TGASND-IKVATSIARNMVTQW----------------------GFSEKLGP---LLYAEEEGEIFLGRSVAKAKHMSDETARI-----IDQEVKLLVERNYQRARKLL--LENMDVLHSMKDALMKY-ETIDAPQIDDLMN.... 594
30 -13.400[O] KOG0734 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  14  267..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................LDSAVDPVQMKNVTFEHVKGVEEAKQEVVEFLKNPQKFTILGGKLILLVGPPGTGKTLLARAVAGEADVPFYYAS-GSEFDE--------MFVGVGASRIRNLFREAKANAPVIFIDELDSVGGKRIESPMHPYSRQTINQ----------LLAEMD-EGVIIIGATNFPEALDNALIDMQVTVPRP--DVKGRTEILKWYLFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDN-KNKTITAYHESGHAIIAYYTKDAMPINKATIMPRG--PTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRV--AEELIF--------GTDHIT-TGASSD-FDNATKIAKRMVTKF--------------------------------GMSEKLGVMTYSDTGKLSPETQSAIEQEIR-----------ILLRDSYERAKHIL--KTHAKEHKNLAEALLT-YETLDAKEIQIVLE.... 709
31 -13.300[O] KOG0729 26S proteasome regulatory complex, ATPase RPT1  ali follow..  15  44...................................................................................................................................................................................................................................................................................................................................................QIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQVARCTKIINADSEDPKKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTY------------------SDVGGCKEQIEKLREVVETPLLHPERFVNLVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQK---------YVGEGARMVRELFEMARTKKALIFFDEIDAIGGARFDDGAGG------DNEVQRTMLELINQLD-PRGNIKVLMATNRPDTLDPALMDRK--IEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNK........................................................................................................................................................................................................................................................... 415
32 -13.300[O] KOG0728 26S proteasome regulatory complex, ATPase RPT6  ali follow..  15  28..............................................................................................................................................................................................................................................................................................................................................EELQLVVAEKHQNLRRL------QAQRNELNAKVRMLREELQLLQEQGSYVGEVVKPMDKKKVLKVHPEGKFVVDLDKNIDINDVTPNCRVALRNESYTLHKILPNKVDPLVSLMMVEKVPDSTY------------------EMVGGLDKQIKEIKEVIELPVKHPELFDALVLLYGPPGTGKTLLARAVAHHTECTFIRVSGSELVQK---------FIGEGSRMVRELFVMAREHAPIIFMDEIDSIGSSRIESGSGG------DSEVQRTMLELLNQLD-ATKNIKVIMATNRIDILDPALLDRK--IEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAK........................................................................................................................................................................................................................................................... 388
33 -13.200[O] KOG0727 26S proteasome regulatory complex, ATPase RPT3  ali follow..  17  42..................................................................................................................................................................................................................................................................................................................................................................................................EFTDIQEEYVKDEQKNLKRELLRAQEEVKRIQSVPLVIGQFMEMVDQNNGIVGSTTGSNYYVRILSTINRPPEADSSISLLSQSEKPDVSYNDIGGCDIQKQEIREAVELPLTHHELYKQIVLLYGPPGTGKTMLAKAVANHTTAAFIRVVGSEFVQK---------YLGEGPRMVRDVFRLAKENAPIIFIDEVDAIATARFDAQTGA------DREVQRILMELLNQMD-QTVNVKVIMATNRADTLDPALLDRK--IEFPLPDRRQKRLVFQVCTSKMNLSDEVDLEDYVSRPDKISAAEIAAICQEAGMHAVRKNRYVILPKDFEKGYRA........................................................................................................................................................................................................................................................... 395
34 -12.900[O] KOG0743 AAA+-type ATPase  ali follow..  12  12.....................................................................................................................................................................................................................................................................................SSLFSAYASLTGFLMLFRSMLHDFV-------------PEKLRSYFSSLLDFFTPKSKYLTVIIDENFGLNRNQVFDAAEMYLRSKIGPETERLRVGKIPKQKHFTISIERGEEIESEVKWSYVQSENEKGDKVKRYYELTFEKKLRDKVLNSY--LTHVVAESEEIKRNLRVVKLYSRDVYASDDDDGMAGGNWGCINLEHPSTFDTLKKKIIDFLKRKEFYKRVGKAWYLLYGPPGTGKSSLIAAMANYLKFDVFDLELSSIYDNGELK------------RVLLSTTN----RSILVIEDIDCNAEVRDREATLSGILNFIDGLWSSF------------DERIIVFTTNHKERLDPALL-RMDVINMSYCTGLGFRTLVSNYLGLDGLNHPLCEEIEALVDSTEVEELMQDDDTDVVLRGVISFVEKRKVERSKKEVSICKATDDDEKQNGSLGCVKKKKKGGKQKGKGKARSKEIPQDNCGFRLTEMFPSISNISLSPSSLFTAYASLTGLRWTYVESENEASQKEKRYYELTFEKKLRDKVMNSYLSHVVAESEETKRSTFETLAMDPGAKKKIIDDMERFLKRREGKAWKRGPGTGKSSLIAAMANYLKFDVEYEEGYYGRVTLSGLLNFVDGLWSS------FGDERIIVFTTNHKERLD-PALLRPGMSYCTGLGFRTLVSNYLG 897
35 -12.700[DL] KOG1970 Checkpoint RAD17-RFC complex, RAD17/RAD24 component  ali follow..  10  3................................................................................................................................................................................................................................................................................................................................................................................KTFLRPKVSSTKVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLS---NEPW---------VDKYKPETQHELAVHKKKIEEVETWLKAQVLQPKQGGSILLITGPPGCGKTTTLKILSKEHGIQVQEWI--QKDDFKGMFNTESSFHMFPYQSQIAVFKELRTDKKIILVEDLPNQFYRD-----SHTLHEVLRKYVRI-------------GRCPLIFIISDSLSFPKEIQEECSISNIS-FNPVAPTIMMKFLNRIVTIEANKNGGKITVPDKTSLELLCQ--GCSGDIRSAINSLQFSSSKGENNLRPRKKGMSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGKDVSLFL................................................................................................................................................................................................................. 396
36 -12.600[L] KOG0480 DNA replication licensing factor, MCM6 component  ali follow..  12  303..............................................................................................................................................................................................................................................................................................................................LRGDIVERAKAGDKCAFTGILIAVPDVSQLGIPGVKPEAYRDSRNFGGRDADGVTGLKSLGVRDLTYKLSFLACMVQPDDANDKSGADVRGDGSQ-GIEEQDEFLQSLSQEEIDDLRAMVHSDH--------------------------YSRLTNSLAPSVYGHEIIKKGILLQLKLTPEGINLRGDLICIVGDPSTSKSQFLKYVCNFLGKASSAAGLTAAVVKDEETGDFTIEAGAL------------ADNGICAIDEFDKMDLSD-----QVAIHEAME-QQTISIAKAGIQATLN-ARTSILAAANPIGNMSAPIMSRFDLFVVLDECNESVDRHLAKHIVDIHRLRDDAMQPEFKLNTESCAEIVKKYKQKNSYRITVRQLESMIRRQSIIHVERDDIEVEEDDAEAQELENDNTNTTNGNDNVSSEEALQKPKVKITYDKYVSIMNGILQVLRQRSTEGVDGVPAG----------SYLELREDQFHTEEDIIYEVGLVRKVLTRLVHES-----IIMEIQNLTDSAVRLPFEERVFSIHLSNGDVPN................................................................................................. 892
37 -12.500[O] COG1222 ATP-dependent 26S proteasome regulatory subunit  ali follow..  16  19.........................................................................................................................................................................................................................................................................................................................................................ERVREKIRMLNSETRILQSRNTIKHDISTKNASIAENMERIRLNKQLPYLVGNVVEVLDEHSGVVNASTRMSSYLPITGLIPNSELRPGDLVALHKDTNIVFEKLPPDY-----MKVGGMVLKSDAKPDETYEDIGGLERQIEELNEAIVLSLTHPERFEKLVLMYGPPGTGKTLMARACASKTNATFLKLAGPQLVQM---------YIGDGARLVRDAFALAKERKPIIFIDEIDAIGAKRSDSDQTGELLNQLDGFSSS-------------EEVKIIAATNRVDILDPALLDRK--IEFPLPNTLGRKRILQIHARKMSVRDDVNFDELARSTEGFNGAQCKAVCVEAGMAALRKEKTEISQNDFMDGIQE........................................................................................................................................................................................................................................................... 388
38 -12.500[T] COG2766 Putative Ser protein kinase  ali follow..  11  2..................................................................................................................................................................................................................................................................................................................................................................................................NIFDHYRQRYEAAKDEEFTLQDFLTICRQDRSAYANAAERLLMAIGE-PNMVDTAQEPRLSRLFSNRVIAR----------------YPAFEEFYGMEDAIEQIVSYLKHAAQGLEEKKQILYLLGPVGGGKSSLAERLKSLM-QRVPIYVLSANGERSPVNDHPLCLFSALVGKVIRKLEHHAQNDPIMEFVEMFKAPI-----KVLHPLLTATQ-EGNYNGTEGISALPFN---GIILAHSNESEKNNEAFLDRVYIVKVP--RISEEIKIYEKLLNHSELAHAPCAPGTLET---LSRFSILSRLKEPENSSIYSKMRVYDGESLKDTDPKAKSYQEYRDYAGVDEGMNGLSTRFAFKILSRVFNFDHAEVAANPVHLFYVL-----------------------------EQQIEREQFPQEQAERYLEFLKGYLIPKYAEFIGKEIQTAYLESYSEYGQ-----NIFDRYVTYADFWIQDQEYRDPDTGQLFDRESLNAEL-EKIEKPAGISNPKDFRNEIVNRTVIEKKMFSNTEELLPVISFNAKTSTDEQKKHDDFVDRMM-YTRKQVRLLCEWYLR 639
39 -12.400[O] COG1219 ATP-dependent protease Clp, ATPase subunit  ali follow..  20  21.........................................................................................................................................................................................................................................................................................................................................................................................................................................KSQHEVRKLPSVFICDECVDLCNDIIREEVQEAQAESSGHKLPPKEIRTILDQYVIGQERAKKVL---VAVYNHYKRLNQR-ILMIGPTGSGKTLLAETLARLLNVPFTIAD--------ATTLTEAGYVGEDVENIIQKLLQKCAQMGIVYIDEIDKITRDVSGEGVQQALLKLIEPPQGGRKHPQQEFLQVDTRNILFICGGAKFGLIPE-FVGRLPIATLDELDEAALMQILKNALTKQYAKLFEMEGVDLEFRPDALKAVARKLERKTGARGLRSILEGILLDTMYEIPSQQDVSKVVIDE................................................................................................................................................................................................................................................. 400
40 -12.400[S] COG5324 Uncharacterized conserved protein  ali follow..  67................................................................................................................................................................................................................................GLF--ISDDTTNPVIVARGYDKF---NVGEVNFTKWNWIEENCTGPYDVTIKANGCIIFISGLEDGTLVVCSK-EKQLLRQLAAMNINRSDFARLYTHNVTAVAEYCDDSFEEHILEYPLEKAGLYLHGVNVNKAEFETWDMKDVSQMASKYGFRCVQCILKKFLDNCSATGSFEGQEIEGFVIRCHLKSTEKPMYRQWREVTKDYISNKSRVFKFRKHKFITNKYLDFAIPILESSPKICENYLKGFGVIELRNKFNHEKVAELELKNAIDYDKVDERTKFLIFPISVIGCGKTTTSQTLVNLFPDSWGHIQ----NDDITGKDKSQLM------KSLELLSKKE--IKCVIVDRNNHQFRE------RKQLFEWLNELKED-----YLVYDTNIVIGVSFAPYDKLSEIRDITLQRVQSIKWDELGEKKVVGIMNGFL--KRYQPVNLDKSPDNMFDLMIE--LDFGQADSSLTNAKQILNEIHKAYPILVPEIPKDDEIETAFRRSLDYKPTVRKIVGKGNNNQQKTPKLIKPTYISAKIENYDEIIELVKRCIASDAELTEK--KHLLASGKVQKELHITLGHVMSSREKEAKKLSYCNRYTDQITEYNNNRIENAQGSGNNQNTQVKTTDKLNFRLE----KLCWD--EKIIAIVVELSKDKDGCIIDENNEKIKGLCCQNKIITLCKLESGVKAVYSNVLCEKVESAEVDENIKV--------VKLDNSKEFVGSVYLNF. 827
41 -12.300[O] KOG0651 26S proteasome regulatory complex, ATPase RPT4  ali follow..  17  135..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................LVYKMSHEDPGNISYSDVGGLAEQIRELREVVELPLINPELFKRVCLLFGPPGTGKTLLARAVASQLDCNFLKVVSSAIVDK---------YIGESARMIREMFNYARDHQPIVFMDEIDAIGGRRFSEGTSA------DREIQRTLMELLNQLD-SLGKVKVIMATNRPDTLDPALLDRK--IEIGLPNEQSRLEILKIHSNKITKHGEIDFEAVVKLSDGFSAADLRNVCTEAGMFAIRAEREFVIDEDFMKAVRK........................................................................................................................................................................................................................................................... 390
42 -12.100[R] COG2607 Predicted ATPase (AAA+ superfamily)  ali follow..  12  2.....................................................................................................................................................................................................................................................................................................................................................................................................................................ELNEFLDKAYAVLRRLDAVLPPEPGHTDWNALAFRWQSAGKKGFLEHLPDPHTFPLVRLAGVGRQTELLVR--NTEQFIVGRPANNVLMSGARGTGKSSLVKALLHEYGLRLIEVDKSDLIGLPYL---------------LTLLKECPEK--IVFCDDLS-----ESGDETYKALKTALDGGLSQR------------ANVLVYATSNRRHLMPEYFDENAGTTGMRG-AVEEKISLSDRF---------GLWLSFYPFDQNDYLAAVQNWLEDFGV-PYDETAQMAALQWAQT............................................................................................................................................................................................................................................................... 261
43 -12.000[L] KOG0477 DNA replication licensing factor, MCM2 component  ali follow..  13  242.....................................................................................................................................................................................................................................................................................HVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVR---VEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLNHVAKKDNKVAVGELTDEDVKMITSL-----SKDQQIGEKIFASIAPSIYGHEDIKRGLALALKNPGGKHKVRGDIVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGGLT-AYVQRHPVSREWTLEAGALV-------ADRGVCLIDEFDKMNDQD-----RTSIHEAME-QQSISISKAGIVTSLQ-ARCTVIAAANPIGDLTEPIISRFDICVVRDTVDPVQDEMLARFVVGSHVRHHP-TYGVEPLPQEVLKKYII-YAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARIHLRD---------YVIEDDVNMAI........................................................................................................................................................................................................ 795
44 -11.900[L] KOG0478 DNA replication licensing factor, MCM4 component  ali follow..  12  223.....................................................................................................................................................................................................................................................................................QDLYRQLICYPQEVIPGFDMAINEMFFERYPAALLEHQIQRPFNA-TRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRINQPTLCTNCNTNRLIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLNKRLYEDEEGKDHIFPPERVELLQLL-----AKKPDIYDRLARAIAPSIYENDDIKKGILLQLHATLGRQNFRSEILLLCGDPGTSKSQMLQYVFNLVPRSQYAVGLTAYVTKDPETRQLVLQTGAL------------ADNGVCCIDEFDKMNDSTR-----SVLHEVME-QQTLSIAKAGIICQLN-ARTSILAAANPAEQLPHTLLSRFDLI-VLDPQDEIFDKRLASHLVSLYYVTRHEEEDTM-FDMSVLRDYIA-YAREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQISAYPRQLESLIRLSEAHAKVRLSN---------QVELLDVEEAWRLHREALKQSATDPLSGLTTGLSTAARKKRADLVAAIKENLKKKGKVLTVPYQ---KLFSDIKEGSQIMIT................................................................................................................................. 838
45 -11.500[L] KOG2028 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  14  110.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RTLDDVVGQDHL--------LSPSSLLRSAVESNRLPSIVFWGPPGTGKTSIAKSLINSSKDP-LSAVTSGVKDVRDA-------------ESAKRLNLEGRKRTVLFMDEVHRFNKSQQ-----DTFLPVIEDGS---------------ILFIGATTENPSFHLITPLLSRCRVLTLNPLKPNHVETLLRRAVDDSERGL----PNSVEVDDSVIEFLAN--NCDGDARVALNALEISATMATTRAGTDAVVSIDDAKEALQCKHLAYDKAGEQHYN----------------------------------------LISALHKSMRGGD---ANAAIYWLARMLEGGEEPLYIARRLIRFASEDIGLADPSALTQAVAC--------QASHFLGMPECNVI----QCTAYLALAPKSIAVYRAIGAAQKVVKDSVGQNEGVPLHLRNAPTKLMKELG-KEYIYPPSDPSSAAGLPPSLLHHKFLEWPEGASGDFQDQEH 523
46 -11.400[L] COG0470 ATPase involved in DNA replication  ali follow..  21  25.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DEVYGQNEVITTVRKFVDEGKLPH------LLFYGPPGTGKTSTIVALAREIYGKNYSNMV----NASDDRG-----VRNQIKDFASTRQIFSKGFKLIILDEADAMTNAAQ-----NALRRVIERYT---------------KNTRFCVLANYAHKLTPALLSRCTRFRFQPLPQEAIERRIAN-----------LVHEKLKLSPNAEKALIE--LSNGDMRRVLNVLQSCK..................................................................................................................................................................................................................................................................... 216
47 -11.100[L] COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family  ali follow..  10  25......................................................................................................................................................................................................................................................................AEEIAKLPYEDHQRIVLNVNDMRLFDKGLARGVLEDPATLVPFIEDELSDIGGRKIFLGIYFLNPRTLSSVYIGKMVCVEGIVTSCSICRPKVMKSVHYNPSKNVFYSKEYRDATMVTKLPVTNSVYPTTEFGLSEYFDYQTVVLQEMPEKAPPGQLPRSVEVILSFDLVDGLKPGDRAKIYGIYKSFRTVVIANNIEKAEEEEVEVEPGVEFIAPSIFGHDIVKRSIALLLVVMRNGSKIRGDIILLVGDPSTAKSQLLRYVLNAAQLSIAGVGLTAAVVLDKDTGEKRLEAGAM------------ADRGVVCIDEFDKMSDGDR-----VAIHEVME-QQTVTIAKAGIHTTLN-ARCSVLAAANPIWRLPESLLTRFDLI-TLDKSNTDIDQLVSGHVLRMHMLTQGYEEEGMGVKQEVFRAYIRY------CRQKKPVLSREAAGLIAREYTSLRQSKDRKEQIVSITPRMLETMIRLATANAKLRLSD----VVEYDDAECAVNLVKDSLFQKIVKPAKRIKAAAPEEQDEFDLVDEKGTLKQRLEAAMIDEDKINFVSHALYDYSADPKNPQDFMKYLGTDVSVTEQEVEEI-LSRLAEKDLILFENGRI............................................................................................ 683
48 -11.000[L] KOG0990 Replication factor C, subunit RFC5  ali follow..  19  51.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DDVAAHRDIIDTIDRLTNENKLPH------LLLYGPPGTGKTSTILAVARKLYGPILELNASDDRGIDVVR------------QQIQDFASTQSFSLLVLLDEADAMTKDAQ-----FALRRVIEKYT---------------KSTRFALIGNHVNKIIPALQSRCTRFRFAPLDGVHMSQRLKH-----------IEAERLVVSDCGLAALVR--LSNGDMRKALNILQSTH..................................................................................................................................................................................................................................................................... 244
49 -11.000[L] KOG0991 Replication factor C, subunit RFC2  ali follow..  17  48.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NEIVGNEDTVSRLEVFAREGNVPN------IIIAGPPGTGKTTSILCLARALLGPMLELNASNDRGIDVVRNKIKMFAQQ-------KVTLPKGRHKIIILDEADSMTDGAQ-----QALRRTMEIYS---------------KTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMN-----------IEKERVPYTDDGLEAIIF--TAQGDMRQALNNLQSTF..................................................................................................................................................................................................................................................................... 240
50 -11.000[R] KOG2170 ATPase of the AAA+ superfamily  ali follow..  16  60..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................PDVNFNYHTLDADIANLLFGQHLVKDVVVNSIKSHWYNENPRKPLLSFHGYTGSGKNYVAEIIANNTRSTFVQHIVATNDFPDKNK---EEYQVELRNRILTTVQKCQ--RSIFIFDEADKLPE-----QLLGAIKPFLD--------YYSTISGVDFRRSIFILLSNK-QLRLEAFERELMNFSYNEKGGLQMSELISNHLIDHFVPFLPLQREHVDFVERVLNSLQYFPESSSGCKRVDAKTDLEMAKIRPLLSSVH.......................................................................................................................................................................................................................................................... 351
51 -10.900[L] KOG0482 DNA replication licensing factor, MCM7 component  ali follow..  10  148.....................................................................................................................................................................................................................................................................................................................................SIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSLSFTPVHDCPSDDCRVLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGEVHRIICINKNDEISDKDAELTPEELEE-----LAQDDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKRPDGMKIICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMGGALV-------ADQGVCCIDEFDKMADQD-----RTAIHEVME-QQTISIAKAGIMTTLN-ARVSILAAANPAFQLPAALLSRFDLL-IQDKPDRDNDLRLAKHITYVHSHSKQPPTRVKALDMNLMRRYINL------CKRKNPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGILRLSTALARLRLSD----SVEKDDVAEALRLLEMSKDSLNQIHEHQKGHVPNTSD--------------------------RIFAIVRELAGSGKAVKISDIMDRCTTKGFKPDQVDKC-IDDYEELNVWQVNMGRTKITFM....................................................................................... 720
52 -10.800[L] KOG0481 DNA replication licensing factor, MCM5 component  ali follow..  10  77.....................................................................................................................................................................................................................................................................................ETLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLSSIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLKPSRRDGREKAVVGVRAPYMRVV-----RRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLKRLPDGLCRRGDIVLLLGDPGTAKSQLLKFVEKVAPIAVYTAGLTASVMKDPQTRNFVMEGGAM------------ADGGVVCIDEFDKMREDD-----RVAIHEAME-QQTISIAKAGITTTLN-SRCSVLAAANSIFDFMPTILSRFDMI-VKDIHDESRDITLAKHIINVHLKSAPSEPAEGEISLSTFKKYIH-YCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQP--FATDEHVNEALRLFQVSTLDAAMTGSLAGAEGFTTEEDQETLNRIEKQ--------------------LKRRFAIGSQVSEQNILQDFLRQKYEERTVMKV-IHTMIRRGELQHRMQRKMLYRIC...................................................................................... 733
53 -10.700[L] COG1193 Mismatch repair ATPase (MutS family)  ali follow..  10  92........................................................................................................................................................................................................................................................................................LKRVLLASRELQNFYTNLENVSLEELALWFEKLHDFPQLQGNLQAFNDAGFIENFAS--ELARIRRKIHDSESQVRDVLQDLTYRNKIAGVVHDISASGNTVYIEPREVVKLSEEIASLRADERYEMLRILQEIS---------ERVRPHAAEIANDAWIIGHLDLIRAKVRFIQERQAVV------------QLSENQEIQLLHVCHPLVKNAVANDVYFGQDLTAIVITGPNTGGKTIMLKTLGLTQADKGSRVGI--IGDEQSIEQSLSTFSSHM--TNIVDILGKVNQHSLLLLDELGAGTDPQEGAALAMAILELRLRQIKTMATTHYPELKAYGIETAFVQNASM--EFDTATLRPTYRFMQGVPGRSNAFEIAKEVIVGDASQQIDQDNDVNRIIEQLEEQTLESRKRLDNIREVEQENLKMNRALKKLYNELNREKETELNKAREQAAEIVDMALSESDQILKNLHSKSQLKPHEIIEAKAKLKKLAPEKVDLSKNKVLQKAKKKRAPKVGDDIVVLSYGQRGTLTSQLKDGGLIKMTLEEKEFDLVQAQQEKPVKKKQVNVVKRTSGRGPQARLDLR-------------GKRYEEAMNEL---DTFIDQALLNN-----AQVDIIHG---IGTGVIREGVTKYLQRNKHVKSFGYAPQN--SGATIVTFK........... 777
54 -10.400[L] COG2812 DNA polymerase III, gamma/tau subunits  ali follow..  24  16.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QDVVGQEHITKTLQNALVQEKF-----SHAYLFSGPRGTGKTSAAKIIAKAINRACKGITSGSIVDVMEIDAASNNGVDE-----IRDIRDHVKFAPVYIIDEVHMLTTGAFN-----ALLKTLEPPSH----------------AIFILATTEPHKIPLTIISRCQRFDFKRISNDALVGRMKE-----------LTHEGIEAEDEALVLVAR--AAEGGMRDLDQAISFADERVTVEDVLA........................................................................................................................................................................................................................................................... 239
55 -10.300[L] COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  13  24.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QTVEQYIGQQHI--------LGPGKPLRRALEAGHIHSMILWGPPGTGKTTLAEVAANYANAEVERVSASGVKEIRAAIEKAR-------------ENKLSGRRTILFVDEVHRFNKSQQ-----DAFLPHIEDGT---------------VTFIGATTENPSFELNNALLSRARVYKLTSLNQQEILQALHQAI---ADTERGLGKVAAVFADNVLDRLAE--LVNGDARMSLNYLELLY-----------------------------DMAREDDQGRKQIDLPLLAEVAGEKVSRFDNKGDIWYD-----------LISAVHKSIRGSD---PDAALYWAARMISAGCDPLYIARRLLAIASEDVGNADP----------------RGMQVALAAWDCFTRVGPAEGERAIAQAIVYLACAPKSNAVYTAWKQALSDAHNLPEFEVPPHLRNAPTRLMKDL-EPGAYAAGECYFPPEMSGTRYYQPTPRGLE....... 425
56 -9.990[DL] KOG2035 Replication factor C, subunit RFC3  ali follow..  15  19......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VDYHIEQANHLKFLSADCMPHLLFCGPSGAGKKTRIKCLLRELKLEIQTVSSNYHIEPSDVGIYDRVVV-----DLVKEMAQTSQIESVVVLCEADSLTR-----DAQHGLRRTMEKYANN---------------CKIVLSCESLSRIIEPLQSRCIIINVPAPTDEDVTKVLRK-----------IERESFLLPENVLQKIVE--KSEGNLRRAILMTEALRMENESGVAES........................................................................................................................................................................................................................................................... 246
57 -9.890[R] KOG1400 Predicted ATP-dependent protease PIL, contains LON domain  ali follow..  207.....................................................................NHLSRVPGVDYLEVGSVHHMLIFLH-QHILFPGEVLPFMIDGRMFDEDMPGL----DGLIFGVSFPRLQPPED------NPHKLYGVTCQIYERGES------------------------------------------------------------------GRGLVFYKSRALQRIVINCDRNPTSKCFSKVKILPEYFLPEDMGSMARFRDIPSMRDKYRRFQLSTTTRQRLESQKIDTMPKCPIQLSFWLVRNLH-LTEKMMRLTFLTDSVNTRLQLIKSTFKDETLFFCRYCNSSLALCSDLFAMSKHGVQTQY-------------------------CNPEGYIHETNTVYRVISHAIGYSGEPSTKFSWFPGY-QWHIHVGWEFKAVHP-------NLTPKVFFGL--AGSSVRIGKASEYSPFNGTTYVV----------RNMMRMISSDME......................................................................................................................................................................................................................................................................................................................................................................................................................................................... 585
58 -9.760[L] KOG0219 Mismatch repair ATPase MSH2 (MutS family)  ali follow..  14  388........................................................................................................................................................................................................................................................................................MVEQVVDFEAIERGEYLVKASFDSRLMELQQMMTELYSKMEELQF-----KCSQELNLDGKNQVKLESVAKLGHHFRITVKDDSVLRKNKNYRIVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQQLSIVEEI---------IHVAVGYAAPLTLLNNELAQ-------LDCLVSFAIAARSAPTPYVRPKMLEEGARELVLEDVRHPCLEFIANSVDFKKEECNMFIITGPNMGGKSTYIRSVGSMVDSILGRV---GASD--NIIKGLSTFMVEM----TSGIIRTATDKSLVIIDELGR-GTSTYEG--AWSIAEHLAKETKCFFATHF-----EITKL-------------AETLSTVKNCHMAAVADADDFTLLYQVRSGVMEKSFGIQ---------------------ARLANFPEHVVQNAQEVYNEFEDEHVDKQKKEDKALLEKIQVAIQQLSTAGNNVDINVEDLTQLVTQFTKDIEQL........................................................................................................................................................................................................ 840
59 -9.710[KT] COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains  ali follow..  11  249...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAFHQSHTSFSVANAPDEPHIEQLVGECRVMRQLKRLISRIAPSPSSVM-VVGESGTGKEVVARAIHKLSGRRFIAINCAAIPEESELFGYVK---GAFTGASANGKT---ANTGTLFLDEIGDM--------PLMLQAKLLRAIEAREILPIGASSPIQVDIRIISATNQNLAKFREDLFYRLNVIPITLPPLRERIELLVHYFLHLHTRRLGSVYPGIA---PDVVEILRKHRWPGNLRELSNLMEY-----LVNVVPSGEVIDSTLLPPNLLNNGTTEQSDVTEVTEAHLSLDDAGGTALEEMEKQMIREALSRHNSKKQVADELGIGIATLYRKI............................................................................................................................................................................. 584
60 -9.570[R] COG5545 Predicted P-loop ATPase and inactivated derivatives  ali follow..  10  139............................................................................................................................................................................................................................IYRYSDVRQAIASGKPV-FVVEGERIADS---LWARGIAATTNIGGAGKYRSYGNYQSALEGANLVLCPDRDEPGLKHMEDINSDFPDAKWLYAPPSDFY---WTHLPKHGGLDIQDWIDSGATTKDILQAIEDRRIVVDALNKTLE-LEAERDRPTESKLEQKLNAIRAVWGSRLRWNMLKKQVELDGKRLPLDRIDLKVAIDVHIDISKEQAKSVVLELALANSYSPVVEYLQSVERRYPNVDVSLLDKLAERYTNDPLHAALMKRTLIAAVARAFEPGCKHDEITILQGKQKSLKS----TFWEILAGEEFFTDDLNGTEKDEVLKISQYW--------------------ILEYAEFENSYKKK-----DVSQLKAFLSRKKDSMRRPYGTDIEDFPRSILVGTTNLDEFLYDPTGERFWVIKVLFKKIPAAYRNGEQWRLTEVEDEWLDAANKQYQSTDTWEEAVMAWAELQKEVSVGEILSDVLKIELAKQ--------------------SKAEQNRVAAILRSHGWTRGDRKRVNGRLIRPWVRPQQEVEQEVERGVEQEVERGVE------------EQPQALVTTDLEPECSTCSTNS------PQTFPNFDSNNETAQWIAPQTAA--------VTPQETTPKSLEGQGVEQPVDEPQTQSPQVIESSLELSFEQKLMGNV--IATLTEEWTSEFKSAVWKELTPQERQKQLKALE........................ 836
61 -9.460[L] COG2255 Holliday junction resolvasome, helicase subunit  ali follow..  21  29.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TEYVGQPHVREQMEIFIQAAKQRGDALDHVL-IFGPPGLGKTTLANIIANEMGVNLRTTSGPVLEKAGDLA----------------AMLTNLEPHDVLFIDEIHRLSP---------VVEEILYPAMEDYQLDIMISIKLDLPPFTLIGATTRAGSLTSPLRDRFGIVQLEFYQVADLEHIVSR----------SAKCLGLELTPEGAHQLAR---RSRGTPRITNRLLRRVRDFA................................................................................................................................................................................................................................................................. 234
62 -9.350[L] KOG0220 Mismatch repair ATPase MSH4 (MutS family)  ali follow..  12  496......................................................................................................................................................................................................................................................................................................................EFLDIARRTYTEIVDDIAGMISQLGEKYSLPLRTSLSSVRGFFIQMTTDCIALPSDQLPSEFIKISKVKNSYSFTSADLIKMNERCQESLREIYHMTYMI----------CKLLSEIYEHIHCLYKLSDTVSMLDMLLSFAHACTLSDYVR------EFTDTLAIKQGWHPILEKISAE--KPIA-NNTYVTEGSNFLIITGPNMSGKSTYLKQIARIAKQIFTRI---STDD--DIETNSSTFMKEM----IAYILHNANDKSLILIDELGRGTNTEEGIGICYAVCELLSLKAFTLFATHFLELCHIDALYPNVENMHEVQHVKNTSRNKEAILYT--YKLSKGLTEEKNYGL-KAAEVSSLPPSIVLDAKEITTQITRQILQNQRSTPEMERQRAVYHLATRLVQT............................................................................................................................................................................................................................................................ 898
63 -9.340[QK] COG3284 Transcriptional activator of acetoin/glycerol metabolism  ali follow..  12  127....................................................................................................................................................................................................................................................................................TCAVGACLETGEALTIHQTDHFDNTHTPLSCTAAPIYDIQGELSAVLDISLLSSPILKASQNLALHLVSATVRRIELANLMAQARNQWVLRF-SRSPEFLDVDPEAAISIDGLGRIAG-MTHAGAKILARSTGLDWRDPQQLIGEPVSRFFDIEVDNLSDLTRRRPTRERLVFARDGNALF--AHAIEPHSKVRAPLVSREQIPPALRRLAPVIAALQAKAAKLARTRLPIL-IQGETGTGKEHLARAIHEGSGLEFVAINCAAIPEESELFGYLP---GAFTGASAKGRK---ADGGTLFLDEIGDM--------PLALQSRLLRVLAEGEVLPVGGTAPRKVRIRIVSASHRPLQTL-EDLYYRLNALTLPALRDRPDFDWVLEQLLKR------HGDGELILSPAALSALKA-HDWPGNIRELDNVIGVAAALAENGVVELGDLPDQLLANADTVGGNEASATLSLTLTACNWNISEARRLGLDRSTVHRQI........................................................................................................................................................................................................ 617
64 -9.130[L] KOG0479 DNA replication licensing factor, MCM3 component  ali follow..  10  65.....................................................................................................................................................................................................................................................................................PERAEGLLTQSVLEMNCLQSALQMAINRSDVQAVVKTGFEGTFGERHVNPRTLKSSYLGNLVCCEGIVTKCSTVRQKLLTSVHYCPATNKVLEKKFADFTMLDTAVTNNNYPTETEFGHSVYKDHQTFTIQELPESAPAGQLPRAVDCVADLDLADRVKPGDRVRIIGVFRNHIQMLSKEVIPNFEPQDVKFELLARSLAPSICGHEETKKALLCLLKILNNGSRLRGDIVLLIGDPSVAKSQLLRYVLRMAGRGSSGVGLTAAVTTDPDSGERRLEAGAM------------ADRGVVCIDEFDKMSDID-----RTAIHEVME-QGRVTISKAGIHAKLN-ARCSVLAAANPVYGMQDSLLSRFDLI------------------------------------------VLLDEHDADKDANVAEHVLKLHTYRTQGEADGTVLPMGGGVETISTINMETKKASSSIYEENTQWAGIQDTKILTMDFMRKYIHLARSVQPKLTDEATEYISEVYA-KTDQERTMPVTARQLETLIRLSTAIAKARFS----KVEREDTEKAYNLLHFACFKEKPKA.................................................................................................................... 657
65 -9.020[KT] COG4650 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  15  188.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TRNPHFNRMIE--QIEKVAIKSRAPIL-LNGPTGAGKSFLARRILELKQARFVEVNCATLRGMSTLFGHVKAFTGARESR--EGLLRSANGGMLF-LDEIGEL--------GADEQAMLLKAIEEKTFYPFGSDRQVSSDFQLIAGTVRDLRKFREDLYARINLWTFTLPGLRQRIEPNLDYEVERHASLTG---DSVRFNTEARRAWSPQATWRGNFRELSASVTRMA..................................................................................................................................................................................................................................................................... 423
66 -9.020[T] KOG4658 Apoptotic ATPase  ali follow..  11  1..............................................................................................................................................................................................................................................................................................................................MGSCFSLQVSDQTLNRIFNCLIGKSYIRTLEKNLRALQREMEDLRIQHEVQNKVARDEARHQRR---LEAVQVWLDRVNSVDIECKDLLSVTPVELQKLCLCGLC-------SKYVCSSYKYGKKVFLLLEEVKKLNSEGNFDEVSQPPPRSEVEERPTQPTIGQEDMLEKAWNRLMEDGVG------IMGLHGMGGVGKTTLFKKIFAEIGGTFDIVIWIVVSKGVMISKLQEDIAEKL-SDKATDIHRLKGKRFVLMLDDIEAIGIPYPSEVNKCKV--AFTTRSREVCGEMGDHKPMQVNCLLFKNKVPVIVELAREVAQKLALNVIGETMSSKTLKYSYDSLGDEHIKS-ALFPEDGEIYNEKLIDICEGFIGEDVIKRARNKGYAMLGTLTRANL............................................................................................................................................................................................................................................................. 460

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.