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Query: [O] KOG2004 Mitochondrial ATP-dependent protease PIM1/LON, from COG0516

Results of FFAS03 search in COG0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MYRAGAVLLRGATRTRLLAAASAHQSFATFSQRNQSILMMKSMELAGNSGERRFYSTHDDPIAVDDSLELYKDLGGMSPIQVPADMPNVPMLAINRYPLFPGFIKKVDIVKDDNLKALIRRQLSLKQPYAGVFVKRDDENKEETITSLSEVYPTGSFVQIIEVRDQGSVLELVLSAHRRIRALEPIDEITPKNETPLNGRRARGKRAASATSPLTPPPSPPPLAPSVASVAPEISATEEKEEKTTPPSATGEKQKKGIIMVRTENVVAEPVPKNNETKATMMAIVQTIRDVVQFNQLFGQQINLLLHPSQNVIDNPVYLCDLVATLVQSAETKDLQEMMDEIDVSKRLKIALLLIQKEKAVAKLKYDINKDVEKKVQDHHRKYLLNEQLKVIKKELGIEKDEKTTIIEKIDERIKTLAVPEYALKVINEEKTKLQFLDPHSSEFSVTRNYLEWLTSVPWGLTSPENRRLSVAKKALDEGHYGMKDVKERIMEFIAVNLLRKSIGGKILCFHGPPGVGKTSIAKSIATALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKMIQCMKKVKTENPLVLIDEVDKIGGAGFHGDPASALLELLDPEQNANFNDHFLDVPVDLSRVLFICTANEISKIPGPLRDRMEMIDVSGYLAEEKVEIAHQHLIPQLRKDTSLATEQLKIEDSALEELIKHYCRESGVRNLQQHIERIFRKAALQIAEQQNEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAEQIVVCTENLQKFVGRPKFTSDRMYEVTPPGVIMGLAWTAMGGSALYIETVLKRPVDLTNDKDGSIETTGNLGDVMKESVRTALTVAKGILAREQPDNKFFDKAHIHIHVPEGATPKDGPSAGVTLVSSLLSLALDRPVVQDMAMTGEISLTGKVLPVGGIREKVIAARRVGAKRVFLPNENRRDFDDLPEFMKSELDIRFVSHYDELYEHLFQLast
1 -218.000[O] KOG2004 Mitochondrial ATP-dependent protease PIM1/LON  ali  100  1MYRAGAVLLRGATRTRLLAAASAHQSFATFSQRNQSILMMKSMELAGNSGERRFYSTHDDPIAVDDSLELYKDLGGMSPIQVPADMPNVPMLAINRYPLFPGFIKKVDIVKDDNLKALIRRQLSLKQPYAGVFVKRDDENKEETITSLSEVYPTGSFVQIIEVRDQGSVLELVLSAHRRIRALEPIDEITPKNETPLNGRRARGKRAASATSPLTPPPSPPPLAPSVASVAPEISATEEKEEKTTPPSATGEKQKKGIIMVRTENVVAEPVPKNNETKATMMAIVQTIRDVVQFNQLFGQQINLLLHPSQNVIDNPVYLCDLVATLVQSAETKDLQEMMDEIDVSKRLKIALLLIQKEKAVAKLKYDINKDVEKKVQDHHRKYLLNEQLKVIKKELGIEKDEKTTIIEKIDERIKTLAVPEYALKVINEEKTKLQFLDPHSSEFSVTRNYLEWLTSVPWGLTSPENRRLSVAKKALDEGHYGMKDVKERIMEFIAVNLLRKSIGGKILCFHGPPGVGKTSIAKSIATALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKMIQCMKKVKTENPLVLIDEVDKIGGAGFHGDPASALLELLDPEQNANFNDHFLDVPVDLSRVLFICTANEISKIPGPLRDRMEMIDVSGYLAEEKVEIAHQHLIPQLRKDTSLATEQLKIEDSALEELIKHYCRESGVRNLQQHIERIFRKAALQIAEQQNEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAEQIVVCTENLQKFVGRPKFTSDRMYEVTPPGVIMGLAWTAMGGSALYIETVLKRPVDLTNDKDGSIETTGNLGDVMKESVRTALTVAKGILAREQPDNKFFDKAHIHIHVPEGATPKDGPSAGVTLVSSLLSLALDRPVVQDMAMTGEISLTGKVLPVGGIREKVIAARRVGAKRVFLPNENRRDFDDLPEFMKSELDIRFVSHYDELYEHLFQ 971
2 -166.000[O] COG0466 ATP-dependent Lon protease, bacterial type  ali follow..  36  2..............................................................................YTEQAENNRESLIMPLFEVVVYPKGRAKFLADKVTGEILLAEMKTTEAVYAVGLTVKSGTKPSEISEDS---LYKTGNLLKIGYVQPADDGYLVIAKAVQKVEAVSVYRKNGLFYAMF--------------------------------------------------------------------KPVFDIPDLDEDIQAEMMANIKKAIREISSRFQGSEQFTKPIEK----MDSIDQLIGYVMPYMP-IKLEEKQALLEIVSVRERYFAFFEILMKQKENINFQMEMAKKVTDKISKSNREAMLREQLKMIQEELN-GGDDAASGEGGYRERIEKSTMPEEVKKKALSELKKLETGGPHNPESSVIRNYLDLMLDLPWVTEEKKSIDIDEARRVLESNHNGLEKVKERIIQHLAVMKLKKEKQGSILLLTGPPGTGKTSLGKSIADALGREYVRISLGGVRDEAEIRGHRRTYIGALPGRIIQGMRKAGTKNPVFILDEVDKLS-TSYAGDPASALLEVLDPEQNNTFSDHYLEVPYDLSEVFFIATANSLASIPWPLLDRMETIEISGYTKNEKLAIAKDHLLPCILEEHGLDADKLKIEDEALKGIIDKYTREAGVRGLKKQLARTARFVSEKIVSGKTD----------------------------------LPYVVRADMLKEVLGKEIIRQEEARKENVPGVVTGLAWTPVGGDILFIEGTFM-------PGNGKLTLTGQLGDVMKESAQISLSLVRSRLASTENSFNF-TASDVHIHVPSGATPKDGPSAGVTLFTALTSLITGKAVDPKLAMTGEITLSGAVLPVGGIKEKVLAAHRAGIKKVILPKENERDLEDVPEEVRNELKFVPVETIEEVLKEALG 774
3 -69.300[O] COG4930 Predicted ATP-dependent Lon-type protease  ali follow..  14  6.....................................................................................................................................................................................................................................................................DLPVPAVSEGELVAEGYDLDALLNQHFRGRV-VRKDLTKQLKEGAN--------PVYVLEYLLGMYCASDDDQ------------IVEQGLQNVKRILADNYVRPDEAEKVKSLI-RERGSYKIIDKVSVKLNQKKDVYEAQLSNLG-IKDALVPPQMVKDNEKLLTGGIWCMITVNYFFEEIQMPNMDMEEVFTARTHFNRDQWIDV-----LLRSVGMEPANIEQRTKWHLITRMIPFVENNYNVCELGPRGTGKSHVYKECS-----PNSLLVSGGQTTVANLFYNMASRQIGLVGMWDVVAFDEVAGITFKDKDGVQIMKD-YMASGSFSRGRDSIEGKKTSHLLAPFPAAMIDTAFFDRFHAYIPGWEIPGLITDYLAEYMREMRKRSFSDAIDKFYKLGNNLNQRDVIAVRRTVSGLLLLHPNGSYSKEDVRVCLTYAMERRVKEQLKKLGGLEFFD-----------------------------VNFSYIDNETLEEFFVSVPEQGGSELIPAGMPKPGVVHLVTQAESGMTGLYFETQMT-------AGNGKHSVSGLGSSSAKEAIRVGFDYFKGNLSRVSATAKFSEH-EYHLHVVELHNTGPSTATSLAALIALCSVLLAKPVQEQMVVLGSMTLGGVINPVQDLAASLQLAFDSGAKKVLLPMSSAVDIPTVPAELFTKFQVSFYSEPVDAVYKAL. 691
4 -31.400[R] COG1750 Archaeal serine proteases  ali follow..  19  2.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KSALKILALMLILITPAGAQFENA-QKASIKAVAVTSGDQPTGVVINISVIVT-------PGDGRVFVTTPYTEIMQGSAQLA---AITACDLLGID---FTKYDFFYIIEAEAPIVGGPSAGGVLTVATVAALKNLTIRDDVYMTGMIYPDGYIGPVGGLKYKLEAAAKNGAKIFLIPQGQRITYVEEKKVRRVGIISYIEVEYKELDLVEY. 202
5 -17.900[O] KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain  ali follow..  14  452.......................................................................................................................................................................................................................................KTSTALAQTFNMARRYSPTILLLRHFDVFKNLGSQDGSLGDRVGVSFEIASVIRELTEPVSNGDSSMEEKSNSNFSENEVGKFRGHQVLLIASAESTEGISPTIRRCMGSLNDEQRSE----MLSQSLQGVSQFLNISSDEFMKGLVGQTSGFLPRDLQALVADAGANLYISQESETKKINSLSDDLHGVDIHQASQIDNSTEKLTAKEDFTKALDR-----------KKRNASALGAPKVPNVKWDDVGGLEDVKTSILDTVQLPLLHKDLSG--VLLYGPPGTGKTLLAKAVATECSLNF--LSVKG----PEL----NMYIGESEKNVRDIFEKARSARPVIFFDELDSLAARGASGDSGSQMLAEIDGLSDSS------------QDLFIIGASNRPDLIDPALLDKLLYVGVN--DASYRERVLKALT------------RKFKLSEDVSLYSVAKKCPSTGA-----DMYALCADAWFQAAKRKVSKSDSGDMPTEEDDPDSVVVEYVDFIKAMDQLSPS----LSITELKKY......................................................................................................................................................................................................... 961
6 -16.500[O] COG1067 Predicted ATP-dependent protease  ali follow..  14  116......................................................................................................................................................................................................................................................................................................................................................DIEKLMTKLVTAIPLAFDNEIYFSR-AEKLKNQLAQKQESELESITRTAKERGVSLTNGEEMHTEETFDA------LSKREQEQFSNTIDELE------------VSLRNMVRQLTWEESYSEKIKKLNDEVTLDVIAHFIKKLKLDYSKYPEIKAYLTELQKDIV-------VSRNAEEFPIVVEESPNYHSL-FGYIETATYKGTVFTDFSLIRPGSLHKA-------NGGVLLMDAVKVLEQPYVWDGLKRALRSLDPEP----------IPLDV-KIILFGDYRTYELLAHYDPEFSELFRVTADFADEMPRDADSELHYARFISSIVHDANMLCDRKAIARIIEHSSRTTGDQT--AHIANLLRESNY-VAKQANANLIRQIHVEEALRNQELRVNRLQQSMMETFVNGTTLIQTEGVAIGQVNALSVLATSDHA-----GMPNRITATTSYGEGEIIDIERNVDLGGSIHSKGVMILSAYLSSVFGRTARIPLT--------------------TTITFEQSYGGVDGDSASMAEFCAIVSAFSKQPNRQDIAITGSMNQFGESQPIGGLNEKIVCTIKGDTQGVIIPRSNMHNLADVVKAVEKGFHIWAIDHVTEAIEIF.. 754
7 -16.100[O] KOG0740 AAA+-type ATPase  ali follow..  19  308...................................................................................................................................................................................................................................................................................................................................................................KKYHQPQRASGSSYGGVKKSLGASRSRGILGKFVPPIPKQDGGEQNGGMQCKPYGAGPTEPAHPVDERLKNLEPKMIEL-----------IMNEIMDHGPPVNW------------------EDIAGVEFAKATIKEIVVWPMLRPDIKG--ILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSK---------WVGE---KMVRALAVARCQQPVIFIDEIDSLLSQRGDGE-----------ESSRRIKTEFL-VQLD-DRILVVGATNRPQEIDEAARRRLV----------KRLYIARKQIVINL-----MSKEQCCLSEEEIEQIVQQSDAFSG-----ADMTQLCRGASLGPIRSLQTADIATITPDQVRPIAYIDFENA----------RTVRPSVSPKDLELYE----------------------NWNKTFGC.......................................................................................................................................................................... 672
8 -15.900[O] KOG0733 Nuclear AAA ATPase (VCP subfamily)  ali follow..  12  11....................................................................................................................................................................................................................................................................................................DLERKIHERLVSLKDTIQQTEIEEWPVSTRRAIQ----FVQERDMSLRRIKKPILEKVVEKVLDTLKAEVEEKLASSQDLVLVDSDMEEQSDSNLMEVKDTNVINKSITSLWSSPNLKEIDGEDEKKSVGQESITGSAKRKDRRSKTNGSKRQKAEANREPPSDISL------------------SDIGGLDDCINELLELVAMPIKHPEVYQYTVLLHGPPGCGKTMLANALANELGVPFISISAPSIVSG---------MSGESEKKVREVFEEAKSLAPLMFIDEIDAVTPK--RESAQREMERRI--AQFLTCMDELSFEKTDGKPVLVIGATNRPDSLDSALRDREICLTVPS--QDAREKILRTMAKGLKLSGDFDFRQLAKQTPGYVGADLKALTAAAGIIAIKRIFNEISPLNSDPRFNELDSDMALDSNDSLPLDHSSIIQRYLNAHPDPLSPEELEPLAICPQDFIEAL-----KVQPSSKREGFATVPGVSWNNIGGKTLLAKAVANESKANFISIRGPELLNKYVGE-----SERAVRQVFLRARASSPCVIFFDELD-------AMVPRRDDSLS-RVVNTLLTELDGLSDRSGVYVIAATNRPDIIDP---------AMLRPG-KTLLVDLPDAHERVEILKTLTKQTPLHEEVNLDVL...... 687
9 -15.100[O] KOG0741 AAA+-type ATPase  ali follow..  11  80......................................................................................................................................................................................................................................................................................................................................VSLYTFDKAKQCIGTMTIEIDFLQKKSNDSNPYDTDKMAAEFIQQFNNQAYSVGQQLVFSFNEKLFGLLVDPSILKGEPATGKRQKIEVGLVVGNSQVAFEKAENSSLNLIGKAKTKENRQS-----IINPDWNFEKMGIGGLDKEFSDIFRRAFAFRVFPPEIVEQMGCIHVKG------ILLYGPPGCGKTLLARQIGKMLNAREPKV-VNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGIIIFDEIDAIGSTGVHDTVVNQLLSKIDGVE-------------QLNNILVIGMTNRPDLIDEALLGRLEVMEIGLPDEKGRLQILHIHT--ARMRGHQLLSADVDIKELAVET-LEGLVRAAQSTAMNRHIKA----STKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHGKTALAAKIAEES-PDKMIGFSETAKCQAMKKIFDDAYKSQLSCV------------VVDDIERLLDYVP------GPRFSNLVLQALLVLLKKAPPQGRIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLLGNLKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQ 719
10 -14.700[O] KOG0737 AAA+-type ATPase  ali follow..  13  231...............................................................................................................................................................................................................................................................................KLSGPVLVLGSRLLEPEDDCQEVGEGISALFPYNIEIRPPEDENKTRFEDDMKVIQFQDNKNHIAEVLAANDLECDDLGSICHADTMFLSSHIEEIVVSAISYHLMNNKEPEYKNGRLVISSNSLSHGLNILQEGQGCFEDSLKLDTNIDSKEVAPDNEFEKRIRPEVIPAN-----------IGVTF------------------ADIGSLDETKESLQELVMLGGLLKPCRG--ILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSK---------WFGE---KNVRALTLAAKVSPIIFVDEVDSLGQRTRVGEHEAM-------KIKNEFMTHWDGLMSN-DRILVLAATNRPFDLDEAIIRRFE-IMVGLPSVESREKILRTLLSKEKTENLDFQE---------LAQMTDGY---SG-----SDLKNFCTTAAYRPVRELIKQECLKDQERRKREEAEKNSEEGSEAKEEVSEERGITLRLSMEDMKVAK-----QVAASFAAEGAGMNELKQWNDLYGE.......................................................................................................................................................................... 713
11 -14.400[O] KOG0734 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  14  267..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................LDSAVDPVQMKNVTFEHVKGVEEAKQEVVEFLKNPQKFTILGGKLILLVGPPGTGKTLLARAVAGEADVPFYYAS----SEFDEM------FVGVGASRIRNLFREAKANAPVIFIDELDSVGGKRIESPMHPYSRQTI----------NQLLAEMD-EGVIIIGATNFPEALDNALIDMQVTVPRPDVKGRTEI--LNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPT---LGHVSLLPENDRWNETRAQLLAQMDVSMGGRV--AEELIF----------GTDHITTGASSDFDNATKIAKRMVTKF----------------------GMSEKLGVMT-----TGKLSPETQSAIEQEI-------------------RILLRDSYERAKHIL--KTHAKEHKNLAEALLT-YETLDAKEIQIVLE.... 709
12 -14.100[O] KOG0730 AAA+-type ATPase  ali follow..  14  50.....................................................................................................................................................................................................................................................................................................STAILERKKSPNRLVVDEAINDDNSVVSLHPTTMEKLQLFRGDTIIKGKKRKDTVCIALADETCEEPKIRMNKVVRSNLRVRLGDVISVHQCPDVKYGKRVHILPVDDTVEGVTGNLFDAYLKPYFLEAYRPVRKGDL-EFKVIETDPAEYCVVAP-----TEIFCEGEPVKREDEERLDEVGYDDVGGVRKQMAQIRELVELPLRHPQLFKSIILLYGPPGSGKTLIARAVANETGAFF--FCING----PEI----SKLAGESESNLRKAFEEAEKNAPIIFIDEIDSIAPKREKTNGESQLLTLMDGLKSR-------------AHVIVMGATNRPNSIDPALRGRFDEIDIGVPDEIGRLEVLRIHTKNMKLAEDVDLERISKDTHGYVGADLAALCTEAALQCIREKMDVI-DSIDAEILNSMAVSNEHFHTALGNSNPSALRETVVEVPNVS---EDIGGLENVKRELQETVQYPVEHPEKFEKSPSKGV---LFYGPPGGKTLLAKAIANECQANFISVKGPELLTANVREIFDKARQSAPCVL------------FFDELD-------SIATQRGNSAGDA------GGAADRVLNQLLTEMDGMNAKKTVFIIGATNRPDIALLRPG-QLIYIPLPDEDSRLNIFKACLRKSPVAKDVDVTALAKYT.. 715
13 -14.000[O] COG0464 ATPases of the AAA+ class  ali follow..  17  189..................................................................................................................................................................................................................................................................................................................................................................................................................................................................ITDMTQVELLPEAMEIISEQNIPTVMYEDLGGLKDAISKVREMIELPLKHPELFDRLVLLQGPPGTGKTMLAKAVANESDAYF--ISING----PEIMS---KYYGESERAIREIFEDAEKNAPIIFLDEIDSIARAEVTGEVERRVVAQLLSL---------MDGLKARKNVIVIGATNRPEALDIALRGRFDEIELRVPDTEGRLEIFQIHTRGMPLADNVNLMDFAQITYGFVGADIAALCREAAMSALRRILPKI-PEISKEILDALQVTREDFENALKDVQPSAIREILIEVPNVS---EDVGGLERVKELLKEVVEWPLKNPESYRDEAPKGV---LLYGPPGGKTLLAKAIAHESDANFITAKGSDLLSKRIAEVFTRARQVAPSII------------FLDELD----APIRGTSVGEPQVTARILNQLLSEMDGLEELRAVVVIGATNRPDIIDP---------ALLRPG-ELILVPVPDEGARREIFRVHTKNMALAEDVDIEKLVSFT.. 690
14 -13.700[O] KOG0731 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  16  228................................................................................................................................................................................................................................................................................................................................................................................................FEEKLEEAQEALGVDRHEYVPVTYVSEMVWYQEFMR-PTLLLLGTLIYGARRMQGGLGVGGTGGKNGRGIFNI--GKATITRADKHSKNKIYFKDVAGCDEAKQEIMEFLKNPKKYEDLGAKIALLVGPPGTGKTLLAKATAGESGVPF--LSISG-SDFMEM------FVGVGPSRVRHLFQEARQAAPIIFIDEIDAIGRARGRGGLGG------NDERESTLNQLLVEMD---AGVVVLAGTNRPDILDKALLDRQ--ITIDKPDIKGRDQIFKIYLKKIKLDHEGFAGADINVCNEAALIAARHEGATVTMAHFESAIDRVI-------LEKKNRVISKLERRTVAYHESGHAVVGWFLEHAEPLL----KVTIVPRG-TAALGFAQYVPNENLLMTKEQLFDMTCMT-LGGRA--AEQVLIGKIS-----------TGAQND-LEKVTKMTYAQVAVY----------------------GFSDKVGL---LSFPPRDDGYDFSKPYSNKTGAIIDEEVRDWVAKAYERTVELVEEHKVKVAEILLEKEHQDDLLKI......................... 754
15 -13.700[L] KOG1514 Origin recognition complex, subunit 1, and related proteins  ali follow..  16  247...............................................................................................................................................................................................................................................................................................................................................RELYLTNDFADIEMECVLRHCFVKCPKEFSKASNDGDDVFLCEYEYDVHWGSFKRVAELADGDEDSDQEWNGRKEEEIDYSDEEIEFDDEESVRGVSKSKRGGANSRKGRFFGLEKVGMKRIPEHVRCHKQSELEKAKATLLLAT---SKEMEEITAFIKGSISDDQCLGRCMYIHGVPGTGKTISVLSVMKNLKAEVEAGSVSPY-CFVEINGLKLASPENIYSVIYEGLSGHRVGWKILLIDELDVLVTRN-----QSVLYNILDPTKPN-------------SKLVVLGIANTMD-LPEKLLPRIQRLCFGPYNHRQLQEIISTRLEGINA-----------FEKTAIEFASRKVAAISG--DARRALE-ICRRAA-EVADYRLKKSNISAKSQ----------------------------LVIMADVEVAI-------QEMFQAPHIQVMKSVS-----------SRIFLTAMVHELYKTGMAETS--FDRVATTVSSIC................................................................................................................................... 706
16 -13.600[R] COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain  ali follow..  12  907................................................................................................................................................................................................................................................................................KTSMIEYVAKKTGHKFVRI-----NNHEHTDLQEYIGTYVTDDNGSLSFREGVLVEALRNGY---VLDELNLAPTLEALNRLLDDNRELFIPETQVRKHLSRAFRNRFLEIHFDDELETILHKRCKIAPSYAAKIVQVFRELSLRRQTTRIFEQKNSDLFRWAFREAVGYQQLAENGYM----------LLAERARDQKDKLAVQEV--DMSLKEGPLSKVVWTRPMIRLFC-PVL-LVGDTGCGKTTVCQILAECLHKELHIINAHQDTENGDIIGAQRDLIEKFDGALVTAMKQ----GDFFLLDEISLADD-----SVLERLNSVLELSRTLTLVEHSNAAVS--DGFAFFATMNPKKELSPALRNRFTEIWVPPMVDTEDIL---------KIVEGKLHNNKIELAR-PLVEYAKWHANEYLIRDVILDLNLVLFNAVSMVFIDALGSFTTFSLSNNLASLHAERQRCFAKLNEMASKSADISIKFSDSSFF--FGIPLGDSVESDSTYSLHTDT----TLMNASKVLRALQVLKPILLEGSGVGKTSLITALARELSDQTDLMDLFGSDVPVEGGEGGQFWRDAPFLAAMRNGVLLDELNLASQSVLEGLNAC---------LDHRNEAYILDKVFKA---RKGLPRSFINRFSVVYVEALKEKDMIEIAACNYHQVNEDWRLKIIKFMFRL.. 1739
17 -13.400[R] COG1223 Predicted ATPase (AAA+ superfamily)  ali follow..  17  83.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................TIILVESDPRVIETEIVRDITLDDVVGQEEAKRKAKVILEYLRNPEKFGKWAVLFYGPPGTGKTMMAKALSNEAKTPFLSVK----TKLIGE------HVGDGARRVHELYERARQLAPIVFLDEFDAIALDGDVSEIVNALLTELDGTNSN-------------EGICTIAATNRVELLDASIRSRFE-IEFRLPSYEERLEILRRNLEEFPVPVKGFSGRDLVVIKASLHKAIAEGKDKIETEDLLTAAEKVKMPSRQP............................................................................................................................................................................................................................................................... 346
18 -12.900[O] KOG0726 26S proteasome regulatory complex, ATPase RPT2  ali follow..  16  42............................................................................................................................................................................................................................................................................................................................................PDAAMKLPQVTPHTRCRLKLLKLERIKDYLMMEDEFIRNQERLKPQDEKNEEERSKVDDLRNHAIVSTSVGSEHYVSILSFVDKDQLEPGCSVLLNHKVHAVVGVLSDDTDPMVTVMKLEKAPQETYADIGGLDTQIQEIKESVE-----LPLTHPEYYEEMGIKPPKG------VILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQK---------YLGDGPKLVRELFRVAEEHAPIVFIDEIDAVGTKRYDSNSGGTMLELLNQ------LDGF-----SRGDVKVIMATNRIETLDPALIDRK--IEFPLPDEKTKRRIFTIHTSRMTLAEDVNLSELIMAKDDLSGADIKAICTEAGLMALRERRMKVFKKSKESVLYRKKEGT...................................................................................................................................................................................................................................................... 433
19 -12.900[O] COG1222 ATP-dependent 26S proteasome regulatory subunit  ali follow..  17  26.........................................................................................................................................................................................................................................................................................................................................................RMLNSETRILQSRVDISTKNASIAENMERIRLNKQLPYLVGNVVEVLDEHSGVNASTRMSSYLPITGLIPNSELRPGDLVALHKDTNIVFEKLPPDYDMKV----------------GGMVLKSDAKPDETYEDIGGLERQIEELNEAIVLSLTHPERFEKLVLMYGPPGTGKTLMARACASKTNATFLKLAGPQLVQM---------YIGDGARLVRDAFALAKERKPIIFIDEIDAIGAKRSDSDQTGTMLELLNQ----------LDGFSSSEEVKIIAATNRVDILDPALLDRK--IEFPLPNTLGRKRILQIHARKMSVRDDVNFDELARSTEGFNGAQCKAVCVEAGMAALRKEKTEISQNDFMDGIQEVLSRKKSK................................................................................................................................................................................................................................................... 396
20 -12.800[L] KOG1968 Replication factor C, subunit RFC1 (large subunit)  ali follow..  10  251..............................................................................................................................................................................................................................................................................................................................................................ILETLTRQ-EATDLIKQYGGKVTGAPSVRTDFILLGENAGPRKKQHKIPAINEDGLFYLITHLPASGGTGAAAQAAQQKKEQEEKKILETVARMDDSNKKESQPSQI-W----TSKYAPTSLKDIC-----GNKGVVQKLQKWLQ-PGPDGLGLYKAVLLSGPPGIGKTTAAHLVAKLEGYDVLELNASDTRSKRLLDEQLFGVTDSLAG---ANPVDMAKSRLVLIMDEIDGMSSGDRGG--VGQLNMIIKK-----------------SMIPIICICNDRAH--RPLDRTTFDLR---FRRPDANSMRSR--IMSIAYREGLK-----LSPQAVDQLVQG--TQSDMRQIINLLSTYKLS-----------------------CSEMTPQNSQAVIKNSEKHIVMKPWDICSRYLHGGMFHPSSKSTINDKLELYFNDHEFSYLMVQENYLNTTPDRIRQEPPKMSHLKHLELISSASDLVDSMIHGPLMPTHALMSCVRPASFVAGSGSRQIRFTNWLGNNSKTNKLYRMLREIQVHMRLK------VSANKLDLRQHYIPI--LPVKLSTGHSDVVPEIILNREDFDSITEL......................... 815
21 -12.800[O] KOG0651 26S proteasome regulatory complex, ATPase RPT4  ali follow..  15  2......................................................................................................................................................................................................................................................................................................................LLLQFSNMVEPTGPAIVEDERTKALNSYRRKLAECRDIEQKLKDLRKKE--SEMTKQFDKSENDIKSLQSVGQIVGEVLKQLSEEKFIKATNGPRYVVGCRRSINKEELKQGTRVSLDMTTLTIMRQLPREVDPLVYKMSHEDPGNISYSDVGGLAEQIRELREVVE-----LPLINPELFKRVGITPPKG------CLLFGPPGTGKTLLARAVASQLDCNFLKVVSSAIVDK---------YIGESARMIREMFNYARDHQPIVFMDEIDAIGGRRFSEGTSATLMELLNQ----------LDGFDSLGKVKVIMATNRPDTLDPALLDRK--IEIGLPNEQSRLEILKIHSNKITKHGEIDFEAVVKLSDGFSAADLRNVCTEAGMFAIRAEREFVIDEDFMKAVRKVGDAKRLETK................................................................................................................................................................................................................................................. 400
22 -12.500[O] KOG0728 26S proteasome regulatory complex, ATPase RPT6  ali follow..  16  45.....................................................................................................................................................................................................................................................................................................................................................................QAQRNELNAKVRMLREELQLLQEQGSYVGEVVKPMDKKKVLKVHPEGKFVVDLDKNIDINDVTPNCRVALRNESYTLHKILPNKVDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIE-----LPVKHPELFDALGIAQPKG------VLLYGPPGTGKTLLARAVAHHTECTFIRVS-------SEL----QKFIGEGSRMVRELFVMAREHAPIIFMDEIDSIGSSRIESGSGGTMLELLNQ----------LDGFEATKNIKVIMATNRIDILDPALLDRK--IEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVFEMAVAKVMQKDSEKNMSIKK................................................................................................................................................................................................................................................. 402
23 -12.400[O] KOG0652 26S proteasome regulatory complex, ATPase RPT5  ali follow..  16  30.........................................................................................................................................................................................................................................................................................................................................................RLLDNEIRILKEDAQRTNLEDSYKEKIKENQEKIKLNKQLPYLVGNIVEILEMNPEDDAEENIDLDSQRKGKCVVLKTSTRQTIFLPVVGLVDPDGDLVGVNKDSYLILDTLPSEYDSRVKMEVDEKPTEDYNDIGGLEKQIQELVEAIVLPMTHKERFEKLVLLYGPPGTGKTLMARACAAQTNATFLKLAGPQL----------QMFIGDGAKLVRDAFQLAKEKAPIIFIDEIDAIGTKRFDSEVSGTMLELLNQ----------LDGFSSDERIKVIAATNRADILDPALMDRK--IEFPHPTEEARARILQIHSRKMNVHPDVNFEELARSTDDFNGAQLKAVCVEAGMLALRRDATEVNHEDFNEGIIQVQAKKKAS................................................................................................................................................................................................................................................... 419
24 -12.400[O] KOG0727 26S proteasome regulatory complex, ATPase RPT3  ali follow..  15  1..............................................................................................................................................................................................................................................................................................................................MASAAVASMVLDPKASPALMDLSTADEEDLYGRLKSLERQLEFTDIQEEYQKNLKRELLRAQEEVKRIQSVPLVIGQFMEMVDQNNGIVGSTTGSNYYVRILSTINRELLKPSASVALHRHSNALVDVLPPEADSSISL---------LSQSEKPDVSYNDIGGCDIQKQEIREAVELPLTHHELYKQIVLLYGPPGTGKTMLAKAVANHTTAAFIRVVGSEFVQK---------YLGEGPRMVRDVFRLAKENAPIIFIDEVDAIATARFDAQTGAILMELLNQ----------MDGFDQTVNVKVIMATNRADTLDPALLDRK--IEFPLPDRRQKRLVFQVCTSKMNLSDEVDLEDYVSRPDKISAAEIAAICQEAGMHAVRKNRYVIFEKGYRANVKKPDTD....................................................................................................................................................................................................................................................... 403
25 -12.300[O] KOG0729 26S proteasome regulatory complex, ATPase RPT1  ali follow..  14  31................................................................................................................................................................................................................................................................................................................................................ALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWLAADKQTLQSEQ-INVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVE-----TPLLHPERFVNLGIEPPKG------VLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQK---------YVGEGARMVRELFEMARTKKALIFFDEIDAIGGARFDDGAGGTMLELINQ----------LDGFDPRGNIKVLMATNRPDTLDPALMDRK--IEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSAT................................................................................................................................................................................................................................................ 426
26 -12.100[O] COG0542 ATPases with chaperone activity, ATP-binding subunit  ali follow..  19  327..........................................................................................................................................................................................................................................................................................ALERRFQKVFVGEPTVEDTIAIL--KERYEIHHHVQITDPAIVAAATLSHRYVSDRQLPDKAIDLIDEAASSIRMEIPLDRLERRIQLKLEQQALQKEDDDASRKRLAMLEKELGEKEREYAELTQHIKAELDSAKLEKQLAQAESAEGKEMTLLRYRVTDEEIAEVLSRA-TGIPVAKMMEEKEKLLRMEEELHKRVIGQHEAIEAVSN--AIRRSRAGLSDP-FLFLGPTGVGKTELCKTLANFLENAMVRIDMSEFMEKHSVS----RLVGAPPGYV--YLTEAVRRRPVILLDEVEKA-----HHDVFNILLQVLDDGRLTDGQGR----TVDFRNTVVIMTSNL-QHFRPEFINRIDETVVFHPLGKENIREIATIQLARLIKRMESHGYQLHFTDACLDFIGEVYDPVYGARPLKRAIQQIENPLAQQILSGK.......................................................................................................................................................................................................................................................... 835
27 -12.000[L] KOG0479 DNA replication licensing factor, MCM3 component  ali follow..  11  46..................................................................................................................................................................................................................................................................MNDGESRLVMNLDEIREILPERAEGLLTQSVLEMNCLQSALQMAINRSDVQAVVKTG---TFGERHVNPRTLKSSYLGNLVCCEGIVTKCSTVRQKLLTSVHYCPLEKKFADFTMLDTAVTNNNYPTEDENKNTEFGHSVYKDHQTFTIQELPESAPAGQLPRAVDCVADLDLNKQNGVSSGSFRSIIIINHIQMLSKEVIPNFEPQDVKISKSRNPFEL--CGHEETKKALLCLLLGGMEKIRLRGDIVLLIGDPSVAKSQLLRYVLRMAPRAITTTGRGGLTAAVPDSGERRLEAGAM----------VLADRGVVCIDEFDKMSDID-----RTAIHEVME-QGRVTISKAGIHAKLN-ARCSVLAAANPV-GMQDSLLSRFDLI------------------------------------------VLLDEHDADKDANVAEHVLKLHTYRTQGEADGTVLPMGGGVETISTINMETKKASSSIYEENTQWAGIQDTKILTMDFMRKYIHLARSVQPKLTDEATEYISE-------------VYADIRSFDITKTDQERTMPVTARLETLIRLSTAIAKARFSKKVEREDTE..................................................................................................................... 640
28 -12.000[O] KOG1051 Chaperone HSP104 and related ATP-dependent Clp proteases  ali follow..  17  332..........................................................................................................................................................................................................................................................................................AFERRFQIILVKEPSIEDTISIL--KEKYEVHHGVTISDRALVTAAHLASRYLTSRRLPDSAIDLVDEAAAAVRVTRVLDNLERKLRQRVEIRALEREKDEASKERLKAARKEAEQVEEETRPIREKYELEKSRGSELQDAKRRLDELKAKAELLIDVVGPDQINEIVARW-TGIPVTRLKTEKERLLNMEKVLSKQVIGQNEAVTAVAN--AIRLSRAGLSDP-FLFCGPSGTGKTLLTKALASFMENAMIRIDMSEYMEKHSVS----RLIGAPPGYV--QLTEQLRRRPVILFDEIEKA-----APEVLTVLLQVLDDGRITSGQGQ----VVDAKNAVIIMTSNL-GFFRPEFLNRISIVIFNRLRRVDIRNIVENRI--QKRLQSNHRSIKIEVSDEAKDLLGSAYSPAYGARPLNRVIQNVLNPMAVLILNGQLRDKETAHVVVQNGKIFVKPNHEANANGSADIDMDGIDDDVNDEELE........................................................................................................................................................................................................... 905
29 -11.700[L] KOG0478 DNA replication licensing factor, MCM4 component  ali follow..  12  201...............................................................................................................................................................................................................................................................EEIHTLEEPYLNLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAINEMFFERYPAALLEHQ---FNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMRESCNICSFSTTVEVDRGRINQPTLCTNCNTNHCFRLIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLTPLKTGGLSSSVKSVYKTHVDVVHFRKVDNKRLYEDEEGKDHIFPPERVYENDDIKKGILLQLFGGTKKKNFRSEILLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGGLTAYVTKDPETRQLVGAL----------VLADNGVCCIDEFDKMNDST-----RSVLHEVME-QQTLSIAKAGIICQLN-ARTSILAAANPAEQLPHTLLSRFDLIFLQDEIFDKRLALVSLYYVTRHEEEDTMFDMSVTLSDEAQQRLIQAYVDMRKVGAGRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLDVEEAWRLHREALKQSATDPLSGKIDVG................................................................................................................................................................................................................ 786
30 -11.600[O] COG0465 ATP-dependent Zn proteases  ali follow..  17  136.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................KSKARMLTEDQIKTSFADVAGCDEAKEELVDYLREPSRFQKLGGKIVLMVGPPGTGKTLLAKAIAGEAKVPFFTIS----SDFVEM------FVGVGASRVRDMFEQAKKAAPIIFIDEIDAVGRQRGAGDEREQTLNQMLVEMDG-FEGN--------EGIIVIAATNRPDVLDPALLDRQVVVGLPDVRGREQI--MRRVPLDTDIDASVIARGTPGFSGADLANLVNEAALFAARGNKRVVSMVEFEKAKDKIMMGAERRSMVMTEAQKESTAYHEAGHAIIGRLVPEHDPVHKVTIIPRGRA---LGVTFFLPEGDAISASRQKLESQISTLYGGRL--AEEIIYGPEKVS---------TGASNDIKV-----ATSIARNMVTQW------------------GFSEKLGP---LLYAEEEGEIFLGRSVAKAKHMSDETARI-----IDQEVKLLVERNYQRARKLL--LENMDVLHSMKDALMK-YETIDAPQIDDLMN.... 594
31 -11.500[O] COG1066 Predicted ATP-dependent serine protease  ali follow..  17  1.......................................................................................................................................................................................................................................................................................................................................................................................MAKAPKTAYV--------NDCGAEF-------SRWQGQCAACKAWNTISEVRLVSSSNSAKGDRFSGYAGETRAKIQTLAEISLQETPRFSSGFHELDRVLG-----------------------GVVPGSAILIGGHPGAGKSTLLLQVMCGLAQNMTALYVTGEESLQQVA--RAKRLGLPTDKLNQICQLADQLKPIIVIDSIQVMHLADIQSSPGSV------------------QVRECASFLTRYAKTRQVAII------------MVGHVTKD--TLAGPKVLEHCIDCSILLEGEADSRYRTLRSHKNRFVNELGV------------------------------------------------------------FGMTEQGLREVKNPSAIFLSRGEEQTPGSSVM----IWEGTRPLLVEIQAL--VDHSMLANPRRVAVG---EQNRLALLLAVLHRHGGLQ--------MSDQDVFVNV-VGGVKVTETSADLALLLALISSFRNRPLPQDLVVFGEVGLAGEIRPVPSGQERIGEAAKHGFKRAIVPFAN------RPKSAVPNMDVFTVKKLSDALAILEN 458
32 -11.400[L] KOG0477 DNA replication licensing factor, MCM2 component  ali follow..  12  220...............................................................................................................................................................................................................................................................SDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVR--LVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPE---EVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLNHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFASIAPSI-----YGHEDIKRGLALALFGGEPKNKVRGDIVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGGLT--AYVQRHPVS--GAL----------VLADRGVCLIDEFDKMNDQD-----RTSIHEAME-QQSISISKAGIVTSLQ-ARCTVIAAANPIGDLTEPIISRFDIL-VRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATG------------------SIPITVRHIESMIAHARIHLRDYVIEDDVNMAIRVSFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLVAEQVTYQRNRFGAQQDTIEVPEKDLVDK.............................................................................................................. 868
33 -11.400[L] KOG0480 DNA replication licensing factor, MCM6 component  ali follow..  15  298........................................................................................................................................................................................................................................................................................................................................TLDVILRGDIVERAKAGDKCAFTGILIAVPDVSQLGIPGVKPEAYRDSRNFGKLSFLACMVQPDDANDKSGADVRGDGSQGIEEQ------DEFLQSLSQEEIDDLRAMVHSDHIYSRLTNSL--------------------APSV-----YGHEIIKKGILLQLMGGVHKLNLRGDLICIVGDPSTSKSQFLKYVCNFLPRAIYT-SAAGLT--AAVVKDEET--------TIEAGALMLADNGICAIDEFDKMDLSD-----QVAIHEAME-QQTISIAKAGIQATLN-ARTSILAAANPIGNMSAPIMSRFDLFFVVLDECNESVHIVDIHRLRDDAMQPEFSTEQLQLNTESCAEIVKKYKQKNSYRITVRQLESMIRNEAYSLLRQSIIHVERDDIEVEEDDAEAQELENDNTNTTNGNDNVSSEEALQKPKVK........................................................................................................................................................................................................... 782
34 -10.800[L] COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family  ali follow..  15  169.......................................................................................................................................................................................................................................................................................................................................................................................................TEFGLSEYFDYQTVVLQEMPEKAPPGQLPRSVEVILSFDLDRAKIYFGNQQFPSRFRTVVIANNIEKAEEEEVEVEPGVEFERLSQMKNFGHDIVKRSIALLLVGGNEVVKIRGDIILLVGDPSTAKSQLLRYVLNAAQLSIATTGKGGLT--AAVVLDKDT--GAM----------VLADRGVVCIDEFDKMSDGD-----RVAIHEVME-QQTVTIAKAGIHTTLN-ARCSVLAAANPI-RLPESLLTRFDLI-TLDKSNTDIDQLVSGHVLRMHMLTQGYEEEGMGVKQEVFRAYIRY------CRQKKPVLSREAAGLIAREYTSLRQSKDRKEQIVSITPRMLETMIRLATANAKLRLSD----VVEYDDAECAV........................................................................................................................................................................................................ 571
35 -10.700[L] KOG0219 Mismatch repair ATPase MSH2 (MutS family)  ali follow..  13  362..........................................................................................................................................................................................................................................................................................NIVQCLLESPDTMETLSLDYLKRLKQMVEQVVDFEAIER--EYLVKASFDSRLMELQQMMELYSKMEELQFKCSQELNLDGKNQKLETVKDDSVLRKNKNYRIVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQQIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAARSAPTPYVRPKMLEEGARELVLEDVRHPCLELQEHV-NFIANSVDFKKEECNMFIITGPNMGGKSTYIRSVG-MVDSILGRV---GASDNI-IKG-LSTFMVEM----TSGIIRTATDKSLVIIDELGR-GTSTYEG--AWSIAEHLAKETKC-FATHFHEI-----------------TKLAETLSTVKNCHMAAVADADDFTLLYQVRSGVMEKSFGIQVARLA--------------------NFPEHVVQNAQEVYNEFEDEHVDKQKKEDKALLEKIQVAIQQLSTAGNNVDINVEDLTQLVTQ................................................................................................................................................................................................................ 832
36 -10.700[L] COG2255 Holliday junction resolvasome, helicase subunit  ali follow..  17  29.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TEYVGQPHVREQMEIFIQAAKQRGDALDHVL-IFGPPGLGKTTLANIIANEMGVN-LRTTSGPVLEK--------------AGDLAAMLTNLE-PHDVLFIDEIHRL---------SPVVEEILYPAMEDYQLDIMISIKLDLPPFTLIGATTRAGSLTSPLRDRFGIVRLEFYQVADLEHIVSR----------SAKCLGLELTPEGAHQLAR---RSRGTPRITNRLLRRVRDFAEVRADGAINGEVAMKALDMLNVDAEGFDFMDRKLLLAVIDK-AAAIGEERETIEDVLEPYLIQQGFIQRTPRGRIATNHAYKHFG............................................................................................................................................................................ 329
37 -10.600[O] KOG0743 AAA+-type ATPase  ali follow..  14  27.................................................................................................................................................................................................................................................................................................................................LFRSMLHDFVPEKLRSYFSSLRFFTPKSKYLTVIIDELNRNQVFDAAEMYLRSKIGPETER--LRVGKIPKQKHFTISIERGEEILDTFEESEVKWSYVQSENEKGDKVKRYYELTFEKKLRDKVLNSYLTHVVA-NW---GCINLEHPSTFDTLAMDPNAKKKIIDDLERFLKRKEFYKRVRGYLL--YGPPGTGKSSLIAAMANYLKFDVFDLELSSIYDNGEL---KRVLLST-------------TNRSILVIEDIDNAEVRDREAENQSGILNFIDGLWSSFGDER-----------IIVFTTNHKERLDPALLGRMDVINMSYCTGLGFRTLVSNYLIEALVDSTEVTPAELA------EELMQDDDTDVVLRGVISFVEKRKVERSKTKKEVSICKATDDDEKQNGSLGCVKKKKKGGKQKGKGKARSKEIPQDNCGFRLTEMFPSISNISLSPSSLFTAYASLTGFLMLFRSLFNIGPETARLRVGKLPKQKHFTIYIEKGEEI-ENSELRWTYVESENEASQKEKRYYELRAVKLYSRDGCINLEHPS---TFETLAMDPGAKKKIIDDMKRVGKAWKRGYLLPPGTGKSSLIAAENAQLKSILLSTTNRS-IEDIDCSSA.................... 811
38 -10.400[R] COG2802 Uncharacterized protein, similar to the N-terminal domain of Lon protease  ali follow..  12  7......................................................................PMHVGNARYVKNDDLPKTVPVFPLPGALLLPEGHLPLNIFEPRYLAMIDTAL--ASHRLIGMVQPALHVIEAG--IEGGPLSAVGCLGRITSFSETGDGRVISLTGVCRFRLLE------------------------------------------------------------------EVAGSEPYRSFRHAPFIADLSGEYDEEAVDRENLLRVFRAFLDANQL-------EADWESVERAGNRVLVNSLSMMSP-FGPAEKQALLEAPDLKTRAETLIAIT--EIVLAQGSGEGGTVLQ...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 230
39 -10.300[L] KOG0482 DNA replication licensing factor, MCM7 component  ali follow..  13  149......................................................................................................................................................................................................................................................................................................................................IREVKAQHIGKLVTVRGIVTRCTEVKPMMVVAT--SETYQPVNSLSFTPVHDCPSDDCRVNKAGGLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGEVTRMAQ--AQMIQGLLSETFLQ-------AELTPEELEELAQDDFYEREIYGHLDVKKALLLLLVGGVDKRKIRGNIICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGGLT--AAVMKDPLTGEMTLEGGAL-----VLADQGVCCIDEFDKMADQD-----RTAIHEVME-QQTISIAKAGIMTTLN-ARVSILAAANPA-QLPAALLSRFDLL-IQDKPDRDNDLRLAKHITYVHSHSKQPPTRVKALDMNLMRRYINL------CKRKNPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGILRLSTALARLRLSD----SVEKDDVAEAL........................................................................................................................................................................................................ 634
40 -10.100[O] KOG0739 AAA+-type ATPase  ali follow..  18  8.............................................................................................................................................................................................................................................................................................................................KAIDLVTKATEEDKAKNYEEALRLY--QHAVEYFLHAIKYEAHSDKAKESIRAKCVQYLDRAEK----------LKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQ-----------LMGAVVMEKPNIRW------------------NDVAGLEGAKEALKEAVILPIKFPHLRG--ILLFGPPGTGKSYLAKAVAEANNSTFFSVSSSDLMSK---------WLGE---KLVKNLELARQHKPIIFIDEVDSLCGSRNENESEAA-------RIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFE----------------KRIYIPAQMFRLHLGSTPHNLTDANIHELARKTEGYSG-----ADISIIVRDSLMQPVRK........................................................................................................................................................................................................................................................... 348
41 -10.100[R] KOG2170 ATPase of the AAA+ superfamily  ali follow..  16  62................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VNFNYHTLDADIANLLFGQHLVKDVVVNSIKSHWYNENPRKPLLSFHGYTGSGKNYVAEIIANNTFRTFVQHIVA--TNDFPDKNKLEEYQVELRNRILTTVQKC--QRSIFIFDEADKL---------PEQLLGAIKP-----FLDYYSTISVDFRRSIFILLSNK-GEIARITKEQYE----SGYPREQRLEAFERELMNFSYNEKGGLQMSELISNHLIDHFVPFLPLQ------REHVRSCVGAYLRKRGRGDLVSNVDFVERVLNSLQYFPESSKAFSSSGCKRVDAKTDLEMAKIRPL........................................................................................................................................................................................................... 346
42 -10.100[L] KOG0481 DNA replication licensing factor, MCM5 component  ali follow..  12  72..................................................................................................................................................................................................................................................................LVGFDETLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLSSNANPTNIRQLKSDCVSKL-VKIAGIIVAASGISAKATRMSLKVNPGLEGYALPRKCNTEQAGRPKCPLDPFFIMPDKCKC-------VDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQGIYSIRKVYMRVVGITVDSEGAGAISRYSNITSDEEFGSRDIKKAITCMLFGGSRKRCRRGDIVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGGLTASVMKDPQTRNFVGAM----------VLADGGVVCIDEFDKMREDD-----RVAIHEAME-QQTISIAKAGITTTLN-SRCSVLAAANSIFDFMPTILSRFDMI-VKDIHDESRDITLAKHIINVHLSSNKSAPSE-EISLSTFKKYIH-YCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLS--------------------------IPITVRQLEAVISLAKIRLQPFATDEHVNEALRLFQVSTLDAAMTGSLAGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLRQKYEERTVMKV.............................................................................................................. 710
43 -9.980[T] COG3480 Predicted secreted protein containing a PDZ domain  ali follow..  14  17...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEA---------------GAYQFVTVGVQHATLAHMIYAWLTPF--------------RSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLN----------VTDNSTFKGILNISDTV----TAVNDQTFDSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGI--GGPSAGLMFSLAIYTQIAHPDLRNIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNNYQTALEAAKTIKTDMKIVPVKTLQDAIDYL.. 341
44 -9.810[L] KOG2228 Origin recognition complex, subunit 4  ali follow..  12  554.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GHMDEQTKLYQWVRQTIVLG--EGNSVIIVGPRGSGKSVLVDDILSRAAQESYVVRLNGTYESDEALKSEMNFSDTL-TKLLATLSMTTSAAVIFVLEEFDLFVQHSRQ----MLLYNLFDIAQSRK------------APILIIGLTTRYD-CSESLEKRVKIPMRPPSSLSEFEQILKSVL---YVSDEGGKDQIITCWNQRVDELLSDTRSHQHHYFASRNLKLLYVDLLFPILSMAPDRPLLADEDFANISLKVSDHKVELVKNLSLL---ELALLICAVRFEAR-DIPACNFNSAYQE-----VALEAWETLGSIGLIIPVHPSTNVSGALSRQ-QPEVDNVVSVGLREHRRLPSHYYR.............................................................................................................................. 966
45 -9.790[L] KOG2028 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  15  105................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ERMRPRTLDDVVGQDHLSPSSLLRSAVESNRLPS---------IVFWGPPGTGKTSIAKSLINSSKDRFVSLSTSGVKDVRDA-------------ESAKRLNLEGRKRTVLFMDEVHRFNKS-----------------QQDTFLPV-----IEDGSILFITTENPSFHLITPLLSRCRVLTLNPLKPNHVETLLRRAV----DDSERGLPNSVEVDDSVIEFLANNCDGDA--RVALNALEISATMATTR---------------------------------------AGTDAVVSIDDAKEALQCKHLAYDK-------------------------------------AGEQHYNLISALHKSMRGGDANAAIYWLARMLEGGEEPLYIARRLIRF----------SEDIGLADPSALTQAVACYQASHFLGMPCNVILAQCTAYLA-LAPKSIAVYRAIGAAQKVVKDSVGQNEGVPLHLRNA.................. 468
46 -9.530[Z] COG5245 Dynein, heavy chain  ali follow..  11 1257...................................................................................................................................................................................................................................................................................DVLLLQSDLANFLRRADELPRAVKQEMYKSLFSQVNMLTSVNKILVELKD--GALKPRHWNMIFRDIGKRQIQKNLLDKLEFSLDVMVLNTLNEILLTKIIERAQKEFVIEKSLNRIKKF-----KEAQYEVIEHSSGLKLVREWDVLEQACKEDLEELVSMKASNYYKIFEQDCLDLESKL-W-------VEVQFYWLDLYGILGENLDIQNFL-EYKMITTRAFQLD-TTIEVIHIPNFDTTMIKSSLSTFLERQFPRFYFLGNDDLLKIIGS-----GKHHDQVSKFMKKMFGSIESIIFLEDFITGVRSVEG-------EVLNLNEKIELKDS-IQAQEWLNILDTEIKLSVFTQFRDCLGQLKDGTDIEVVVSKYIFQAI---LLSAQV----TELVEKCLQTNQFSKYWKEVDMKKGLLDKLNKSSDNVKKKIEALLVEYLHFNNVIGQLKNCSTKEEARLLWAKVQKKNDTLDDLNSVFISQSGYLEYIGIP-ATLTDSLHQKYGGCFFGPAGTAFGGRVVVVDSFDYQVLSRLLVG---ITQIGAWGSAVSANIQQIQNGLQVGKSHIEEETPLSPHTAVFITLNPGYNGRS-PENLKKSFREFSMKSPQSGTIAEMILQIM-SLASKIVHFLELLSSKCSSMRT-LKGVLRNCSPISEFGEGEKTVVESLK................ 1999
47 -9.400[LA] KOG2044 5`-3` exonuclease HKE1/RAT1  ali follow..  12  10.....................................................................................................................................................................................................................................................................................................LADRYPKSISDVVEEEPTDGGRGDLIVDITRPNPNGFEFDDMNGIIHPATYDDVFKSMFEYIDHLFTLVRPRKILYLAIDGVAPRAK-----MNQQRSRRFRAAKDAAEAEAEEERLRKDFEMEG--QILSAKEKAETCDSNVITPGTPFMAILSVALQYYIQS-W-----------RYVKVILSDSNVPGEGEHKIMSYIRLQRNLPGFDPNT-CLYG---------ADLIMLSLATHEVHFSI--LREVITYPGQQEK---FVCGQTGHFASDCPGKSGSNNAAADIPIHKKKYQFLNIWVLREYLQYELAIPDPPFMINFERIIDDFVFLCFFVGNDFLPH---------------------------MP-----------TLEIREGAINLLMHVYRKDSGEVLLDR-VEHFIQAVAV---NEDKIFQKRTRIKQSMDNNEEMKQRSRRDPSEVPPEPIDDKIKLGEPGYKERYYAEKFSTTNPEETEQIKYVEGLCWV-----RYYYQGVCSAPFASDLKNLPDLEITFFIGEPFKPFDQL-------------------------MGTLPAASSNALPGEYRKLMTDPSSPILK-PADFELDMNGKRFAWQGIAKLPFIEEKLLLAATRKLEETLTVEEQQRN............................. 606
48 -9.300[L] COG0470 ATPase involved in DNA replication  ali follow..  19  12.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................NLPW---------VEKYRPETLDEVYGQNEVITTVRKFVDEGKL------PHLLFYGPPGTGKTSTIVALAREIYGKNYSNMV------LELNASDDRGIDVVRNQIKDFASTRQIFSKLIILDEADAMTN-----AAQNALRRVIERYTKNT----------------FCVLANYAHKLTPALLSRCTRFRFQPLPQEAIERRIAN-----------LVHEKLKLSPNAEKALI--ELSNGDMRRVLNVLQSCKA.................................................................................................................................................................................................................................................................... 217
49 -9.110[KT] COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains  ali follow..  17  144.............................................................................................................................................................................................................................................................................................................................................................................................................................................SPRSLEILAAIAAATLKMTLTFSELENQAKQTQLRLEELNQEAWSRDSVEIIGNSGPMLAMKADI---DVVAPSQFNIL-IHGETGVGKELVARTIHQRSNRKLVYVNCAAIPEESELFGHVK---GAFTGADRARMGKFALAD-TLFLDEIGELPLS------QSKILRAL---QNHEIQDRVQTVDV---RILAATNRDLKKEVEADLYHRLSVYPIY---RKGDLSLLAGYFVEQARRKLGIT--QLKLHGDVLSQLIQ-YPWPGNVRELEHVINRAALKAKARQRGRPVTTLKVEDLGELQGPRAAMVEPTAQDEPMLGEWIGELGLRDATDEFQR.......................................................................................................................................................................................................... 481
50 -9.090[L] KOG0991 Replication factor C, subunit RFC2  ali follow..  17  35.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................ELPW---------VEKYRPVKLNEIVGNEDTVSRLEVFAREGNV------PNIIIAGPPGTGKTTSILCLARALLGPALKDAM------LELNASNDRGIDVVRNKIKMFAQQKVTLPKIIILDEADSMTD-----GAQQALRRTMEIYSKTT----------------FALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMN-----------IEKERVPYTDDGLEAII--FTAQGDMRQALNNLQSTFS.................................................................................................................................................................................................................................................................... 241
51 -9.060[R] COG0714 MoxR-like ATPases  ali follow..  22  19......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KDEAIRLVLVALLSG---GHAL-LEDVPGVGKTLLAKSLARSINGKFQRVQCTPDLLPTDITGPSSREFEFLPGPAFAN---------ILLADEINRATPR-----TQAALLEVMEEKQTVDGETRLVPHPF-----FVIATQNPIEPLPEAQLDRFALSLSLGYSEAEELKMLQRQQNPEAIAVGDLESCISLEEVEALQKAVRQVKLTEDLQQYLLRLVRASRT................................................................................................................................................................................................................................................................... 233
52 -9.050[T] KOG4658 Apoptotic ATPase  ali follow..  13  1..............................................................................................................................................................................................................................................................................................................................MGSCFSLQVSDQTLNRIFNCLIGKSYIRTLEKNLRALQREMEDLRIQHEVQNKVARDEARHQR---RLEAVQVWLDRVNSVDIECKDLLSVTPVELQKLCL--KYGKKVFLLLEEVKKLNSEGNFDEVS-----------------QPPPRSEVEERPTQPTIGQEDMLEKAWNRLMEDGVG------IMGLHGMGGVGKTTLFKKIHNKFAEIVIWIVVSKGVMISKLQEDIAEKLHNESDKATDIHRVLKGKRFVLMLDDIWEKVDLEAIGIPY--------PSEVNK------------CKVAFTTRSREV-------MGDHKPMQVNCLEPEDAWELFKNKV-----------GDNTLSSDPVIVELAREVAQKCR--GLPLALNVIGETMSSKTMVQEWEHAIHVFNTSAAEFSDMQNKILP-------------ILKYSYDSLGDEHIKSCFLYCALFPEDGEIYNEKLIDYWICEGFIGEDQVIKRARNKGYAMLGTLTRANLLTKVGTYYCVM-HDVVREMALWIASD---FGKQKENFVVQAGVGLHEIPKVKDWGAVRKMSLMDNEEITCESKCSELTTLFLQSNKLKNLPGAFIRYMQ---KLVVLDLSYNRDFNKLPEQISGLVSLQFLD........... 587
53 -9.050[L] COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  16  19................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ARMRPQTVEQYIGQQHLGPGKPLRRALEAGHIHS---------MILWGPPGTGKTTLAEVAANYANAEVERVSTSGVKEIRAAIEKARE-------------NKLSGRRTILFVDEVHRFNKS-----------------QQDAFLPH-----IEDGTVTFITTENPSFELNNALLSRARVYKLTSLNQQEILQALHQAI---ADTERGLGKVAAVFADNVLDRLAELVNGDA--RMSLNYLELLYDMA---------------------------------------REDDQGRKQIDLPLLAEVAGEKVSRFDN------------------KGDIWYDLISAVHKSIRGSDPDAALYWAARMISAGCDPLYIARRLLAIASEDVGNADP--RGMQVALAAWDCFTRVGPAEGERAIAQAIVYLAC............................................................................... 343

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Lesley SA, Kuhn P, Godzik A., Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor SS, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11664-9. Epub 2002 Aug 22.