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# Query Length Result vs. Range Score %id Covered by template(s)
1 gi|108885075|ref|NP_072661.2| DNA polymerase III, beta subunit (MG_001) [Mycoplasma genitalium G37] 380 COG0516 1-380 -82.400 18  [L] COG0592 DNA polymerase sliding clamp subunit (PCNA homolog)
H.sapiens 140-378 -8.730 11  sp|P12004|PCNA_HUMAN Proliferating cell nuclear antigen OS=Homo sapiens GN=PCNA PE=1 SV=1
HGM_OVER 65-282 -2.470 PB038401 Q8RFH0_FUSNN/1-210 PB038401; Pfam-B_38401;
JCSG0516 1-380 -93.400 20  XB5465A NP_344555.1 358603 PDB-2005-08-31
NEW_HUMAN_DOMAINS 34-120 -4.640 12  tr|F8VZC6|F8VZC6_HUMAN Uncharacterized protein OS=Homo sapiens GN=PMEL PE=4 SV=1 (Range: 25-162)
PDB0516 1-380 -93.300 18  2avt_A mol:protein length:378 DNA polymerase III beta subunit
PfamA30U 1-120 -44.100 20  PF00712.17; DPO3B_CAUCR/1-121; DNA polymerase III beta subunit, N-terminal domain
135-256 -39.100 11  PF02767.14; DPO3B_PSEPK/129-244; DNA polymerase III beta subunit, central domain
258-380 -54.600 29  PF02768.13; DPO3B_BACSU/253-376; DNA polymerase III beta subunit, C-terminal domain
SCOP206 1-121 -49.800 21  d1vpka1 d.131.1.1 (A:1-120) DNA polymerase III, beta subunit {Thermotoga maritima [TaxId: 2336]}
129-257 -42.200 14  d4k3la2 d.131.1.1 (A:123-244) DNA polymerase III, beta subunit {Escherichia coli [TaxId: 562]}
258-380 -51.400 23  d1vpka3 d.131.1.1 (A:244-366) DNA polymerase III, beta subunit {Thermotoga maritima [TaxId: 2336]}
VFDB 9-357 -3.680 VFG041320(gi:52842428) (legA2) Dot/Icm type IV secretion system effector LegA2 [Dot/Icm (SS047)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
2 gi|108885076|ref|NP_072662.2| DnaJ domain-containing protein (MG_002) [Mycoplasma genitalium G37] 310 COG0516 2-309 -98.600 17  [O] COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain
H.sapiens 2-310 -90.200 19  sp|Q9UBS4|DJB11_HUMAN(removed signalp:1-22) DnaJ homolog subfamily B member 11 OS=Homo sapiens GN=DNAJB11 PE=1 SV=1
HGM_OVER 9-63 -5.410 21  PB002794 gi|86143885|ref|ZP_01062253.1| hypothetical protein MED217_03525 [Flavobacterium sp. MED217]gi|85829592|gb|EAQ48055.1| hypothetical protein MED217_03525 [Leeuwenhoekiella blandensis MED217]
JCSG0516 2-308 -109.000 19  TM0849 TM0849 282719 Selected-2001-10-12
NEW_HUMAN_DOMAINS 1-59 -7.650 13  sp|Q9UBC1|IKBL1_HUMAN NF-kappa-B inhibitor-like protein 1 OS=Homo sapiens GN=NFKBIL1 PE=1 SV=1 (Range: 294-381)
PDB0516 2-309 -72.000 16  3lz8_A mol:protein length:329 Putative chaperone DnaJ
PfamA30U 2-61 -40.300 46  PF00226.29; Q22028_CAEEL/17-79; DnaJ domain
121-309 -60.900 12  PF01556.16; T0NBZ6_9EURY/129-343; DnaJ C terminal domain
SCOP206 2-76 -46.400 33  d2o37a_ a.2.3.0 (A:) automated matches {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
135-223 -26.600 12  d1exka_ g.54.1.1 (A:) Cysteine-rich domain of the chaperone protein DnaJ {Escherichia coli [TaxId: 562]}
187-265 -15.100 14  d1nlta1 b.4.1.1 (A:110-138,A:213-257) Mitochondrial protein import protein mas5 (Hsp40, Ydj1), C-terminal domain {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
VFDB 11-66 -5.190 26  VFG002034(gi:13508191) (hmw3) cytadherence accessory protein HMW3 [Cytadherence organelle (VF0330)] [Mycoplasma pneumoniae M129]
3 gi|12044853|ref|NP_072663.1| DNA gyrase subunit B (MG_003) [Mycoplasma genitalium G37] 650 COG0516 3-650 -156.000 47  [L] COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit
H.sapiens 2-247 -52.000 24  sp|P11388|TOP2A_HUMAN DNA topoisomerase 2-alpha OS=Homo sapiens GN=TOP2A PE=1 SV=3 (Range: 1-300)
87-408 -65.200 19  sp|Q02880|TOP2B_HUMAN DNA topoisomerase 2-beta OS=Homo sapiens GN=TOP2B PE=1 SV=3 (Range: 151-450)
263-552 -76.400 26  sp|Q02880|TOP2B_HUMAN DNA topoisomerase 2-beta OS=Homo sapiens GN=TOP2B PE=1 SV=3 (Range: 301-600)
411-650 -52.800 28  sp|Q02880|TOP2B_HUMAN DNA topoisomerase 2-beta OS=Homo sapiens GN=TOP2B PE=1 SV=3 (Range: 451-750)
HGM_OVER 472-639 -3.700 20  HGC00522 gi|163636101|dbj|BABG01000172.1|3.0 TMP00580;
JCSG0516 8-650 -198.000 48  TM0833 TM0833 282703 Purified-2005-04-05
NEW_HUMAN_DOMAINS 263-404 -6.810 sp|Q8N6G2|CM026_HUMAN Uncharacterized protein C13orf26 OS=Homo sapiens GN=C13orf26 PE=2 SV=1 (Range: 105-289)
PDB0516 2-649 -191.000 46  4juo_C mol:protein length:670 DNA topoisomerase 4 subunit B
PfamA30U 228-407 -82.400 39  PF00204.23; A9KS52_CLOPH/226-396; DNA gyrase B
548-645 -20.100 20  PF16898.3; K5XBZ3_PHACS/641-767; C-terminal associated domain of TOPRIM
577-639 -46.600 63  PF00986.19; M9X0E0_MANHA/738-800; DNA gyrase B subunit, carboxyl terminus
SCOP206 20-227 -87.700 53  d4k4oa1 d.122.1.0 (A:18-224) automated matches {Enterococcus faecalis [TaxId: 226185]}
228-409 -83.400 36  d1kija1 d.14.1.3 (A:221-392) DNA gyrase B {Thermus thermophilus [TaxId: 274]}
430-629 -97.400 57  d3m4ia_ e.78.1.1 (A:) DNA gyrase beta-prime domain {Mycobacterium tuberculosis [TaxId: 1773]}
VFDB 3-546 -6.550 11  VFG000434(gi:17233482) (pefC) plasmid-encoded fimbriae usher protein PefC [Pef (VF0104)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
4 gi|12044854|ref|NP_072664.1| DNA gyrase subunit A (MG_004) [Mycoplasma genitalium G37] 836 COG0516 16-836 -212.000 39  [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
H.sapiens 17-216 -24.000 29  sp|P11388|TOP2A_HUMAN DNA topoisomerase 2-alpha OS=Homo sapiens GN=TOP2A PE=1 SV=3 (Range: 601-900)
86-392 -57.200 23  sp|P11388|TOP2A_HUMAN DNA topoisomerase 2-alpha OS=Homo sapiens GN=TOP2A PE=1 SV=3 (Range: 751-1050)
246-497 -30.500 15  sp|P11388|TOP2A_HUMAN DNA topoisomerase 2-alpha OS=Homo sapiens GN=TOP2A PE=1 SV=3 (Range: 901-1200)
HGM_OVER 409-496 -3.350 PB045072 _Gut.Meta.Jp.0111663_ gi|163310555|dbj|BABD01000145.1||3 (+ 1662:2028~0 complete)
JCSG0516 17-817 -205.000 40  TM1084 TM1084 282951 Purified-2001-04-24
NEW_HUMAN_DOMAINS 49-177 -5.190 20  sp|Q9H1B7|I2BPL_HUMAN Interferon regulatory factor 2-binding protein-like OS=Homo sapiens GN=IRF2BPL PE=1 SV=1 (Range: 373-516)
PDB0516 12-512 -149.000 52  4ddq_A mol:protein length:502 DNA gyrase subunit A
42-746 -129.000 32  1zvu_A mol:protein length:716 Topoisomerase IV subunit A
512-835 -69.500 32  3uc1_A mol:protein length:327 DNA gyrase subunit A
PfamA30U 44-482 -63.600 20  PF00521.18; A0A0D1DXS4_USTMA/785-1232; DNA gyrase/topoisomerase IV, subunit A
620-665 -13.900 37  PF03989.11; GYRA_HAEIN/641-686; DNA gyrase C-terminal domain, beta-propeller
SCOP206 42-498 -135.000 49  d3ilwa_ e.11.1.0 (A:) automated matches {Mycobacterium tuberculosis [TaxId: 1773]}
512-817 -68.100 33  d4g3na_ b.68.10.0 (A:) automated matches {Mycobacterium tuberculosis [TaxId: 83332]}
VFDB 52-644 -7.070 13  VFG000079(gi:16802278) (clpC) endopeptidase Clp ATP-binding chain C [ClpC (VF0072)] [Listeria monocytogenes EGD-e]
5 gi|12044855|ref|NP_072665.1| seryl-tRNA synthetase (MG_005) [Mycoplasma genitalium G37] 417 COG0516 1-413 -133.000 42  [J] COG0172 Seryl-tRNA synthetase
H.sapiens 1-416 -115.000 27  sp|Q9NP81|SYSM_HUMAN Seryl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=SARS2 PE=1 SV=1
HGM_OVER 255-361 -3.130 15  PB031792 gi|154174791|ref|YP_001409041.1| flavodoxin family protein [Campylobacter curvus 525.92]gi|112804021|gb|EAU01365.1| flavodoxin family protein [Campylobacter curvus 525.92]
JCSG0516 1-416 -136.000 41  TM1379 TM1379 283240 Crystal|NMR-2004-06-10
NEW_HUMAN_DOMAINS 26-104 -5.210 10  tr|B5MDG7|B5MDG7_HUMAN Uncharacterized protein OS=Homo sapiens GN=HMG20B PE=4 SV=2 (Range: 199-286)
PDB0516 1-417 -135.000 43  2dq3_A mol:protein length:425 Seryl-tRNA synthetase
PfamA30U 1-103 -25.500 23  PF02403.20; C5WTV8_SORBI/1-114; Seryl-tRNA synthetase N-terminal domain
SCOP206 1-109 -38.600 22  d1seta1 a.2.7.1 (A:1-110) Seryl-tRNA synthetase (SerRS) {Thermus thermophilus, strain hb27 [TaxId: 274]}
113-417 -113.000 37  d1seta2 d.104.1.1 (A:111-421) Seryl-tRNA synthetase (SerRS) {Thermus thermophilus, strain hb27 [TaxId: 274]}
VFDB 1-244 -11.200 11  VFG045487(gi:52840451) (ravF) Dot/Icm type IV secretion system effector RavF [Dot/Icm (VF0156)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
6 gi|12044856|ref|NP_072666.1| thymidylate kinase (MG_006) [Mycoplasma genitalium G37] 210 COG0516 3-210 -92.400 31  [F] COG0125 Thymidylate kinase
H.sapiens 1-207 -57.800 20  sp|P23919|KTHY_HUMAN Thymidylate kinase OS=Homo sapiens GN=DTYMK PE=1 SV=4
HGM_OVER 4-105 -3.260 10  PB040621 Q8A865_BACTN/1-132 PB040621; Pfam-B_40621;
JCSG0516 5-207 -85.800 28  TM1099 TM1099 282965 Purified-2003-11-26
NEW_HUMAN_DOMAINS 6-88 -6.390 13  sp|Q8IVG5|SAM9L_HUMAN Sterile alpha motif domain-containing protein 9-like OS=Homo sapiens GN=SAMD9L PE=1 SV=2 (Range: 687-863)
PDB0516 1-207 -91.400 27  2ccg_A mol:protein length:225 THYMIDYLATE KINASE
PfamA30U 9-197 -88.700 33  PF02223.15; KTHY_BACSU/8-199; Thymidylate kinase
SCOP206 4-206 -90.100 27  d4hlca_ c.37.1.0 (A:) automated matches {Staphylococcus aureus [TaxId: 282458]}
VFDB 2-202 -9.790 14  VFG001988(gi:15792733) (cysC) adenylylsulfate kinase [Capsule (VF0323)] [Campylobacter jejuni subsp. jejuni NCTC 11168]
7 gi|12044857|ref|NP_072667.1| DNA polymerase III subunit delta' (MG_007) [Mycoplasma genitalium G37] 254 COG0516 2-254 -81.000 16  [L] COG2812 DNA polymerase III, gamma/tau subunits
H.sapiens 2-235 -31.800 12  sp|Q9Y230|RUVB2_HUMAN RuvB-like 2 OS=Homo sapiens GN=RUVBL2 PE=1 SV=3
HGM_OVER 73-201 -3.870 HGC00962 gi|162759780|dbj|BAAZ01005693.1|3.0 TMP01305;
JCSG0516 2-254 -83.000 15  TM0686 TM0686 282556 Purified-2001-02-28
NEW_HUMAN_DOMAINS 19-251 -6.310 10  sp|Q9NYY8|FAKD2_HUMAN FAST kinase domain-containing protein 2 OS=Homo sapiens GN=FASTKD2 PE=1 SV=1 (Range: 164-455)
PDB0516 2-205 -73.500 20  1njf_A mol:protein length:250 DNA polymerase III subunit gamma
2-253 -69.300 17  3glf_B mol:protein length:395 DNA polymerase III subunit tau
PfamA30U 1-186 -32.400 11  PF06068.11; RUVB2_CAEEL/17-408; TIP49 C-terminus
2-143 -75.200 23  PF13177.4; A5VIC8_LACRD/13-171; DNA polymerase III, delta subunit
5-251 -12.100 10  PF03215.13; RAD24_YEAST/58-575; Rad17 cell cycle checkpoint protein
SCOP206 2-205 -74.900 20  d1njfa_ c.37.1.20 (A:) delta prime subunit of DNA polymerase III, N-domain {Escherichia coli [TaxId: 562]}
VFDB 1-238 -12.700 VFG002401(gi:15608935) (eccA5) ESX-5 type VII secretion system AAA+ ATPase EccA5 [ESX-5 (VF0402)] [Mycobacterium tuberculosis H37Rv]
8 gi|12044858|ref|NP_072668.1| tRNA modification GTPase TrmE (MG_008) [Mycoplasma genitalium G37] 442 COG0516 1-442 -112.000 28  [J] KOG1191 Mitochondrial GTPase
H.sapiens 3-442 -98.500 25  sp|Q969Y2|GTPB3_HUMAN tRNA modification GTPase GTPBP3, mitochondrial OS=Homo sapiens GN=GTPBP3 PE=2 SV=2
HGM_OVER 88-141 -3.980 HGC00573 gi|163306732|dbj|BABD01003960.1|2.0 TMP00669;
JCSG0516 26-427 -25.100 12  TT0527A YP_322606.1 404770 Selected-2009-08-14
220-362 -25.400 23  MJ12771A YP_137184.1 403034 Purified-2009-10-17
NEW_HUMAN_DOMAINS 195-334 -5.720 15  sp|Q8IVG5|SAM9L_HUMAN Sterile alpha motif domain-containing protein 9-like OS=Homo sapiens GN=SAMD9L PE=1 SV=2 (Range: 687-863)
PDB0516 1-442 -129.000 28  3geh_A mol:protein length:462 tRNA modification GTPase mnmE
PfamA30U 6-121 -59.300 40  PF10396.7; A4CKF7_ROBBH/5-124; GTP-binding protein TrmE N-terminus
124-439 -92.400 26  PF12631.5; D5XDU4_THEPJ/127-455; MnmE helical domain
SCOP206 5-121 -62.300 42  d1xzpa3 d.250.1.2 (A:1-117) TrmE formyl-THF-binding domain {Thermotoga maritima [TaxId: 2336]}
122-442 -38.800 24  d1xzpa1 a.24.25.1 (A:118-211,A:372-450) TrmE connector domain {Thermotoga maritima [TaxId: 2336]}
217-362 -54.000 32  d2gj8a_ c.37.1.8 (A:) automated matches {Escherichia coli [TaxId: 469008]}
VFDB 218-361 -8.820 27  VFG001859(gi:52842863) (feoB) ferrous iron transporter B [FeoAB (VF0160)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
9 gi|12044859|ref|NP_072669.1| TatD family deoxyribonuclease (MG_009) [Mycoplasma genitalium G37] 262 COG0516 1-261 -104.000 27  [L] COG0084 Mg-dependent DNase
H.sapiens 1-260 -95.000 23  sp|Q17R31|TATD3_HUMAN Putative deoxyribonuclease TATDN3 OS=Homo sapiens GN=TATDN3 PE=1 SV=1
HGM_OVER 74-250 -4.150 11  HGC00374 gi|162831834|dbj|BABA01012875.1|1.0 TMP00304;
JCSG0516 3-261 -105.000 31  TM0667 TM0667 282539 PDB-2002-07-09
NEW_HUMAN_DOMAINS 177-260 -6.510 sp|P14543|NID1_HUMAN Nidogen-1 OS=Homo sapiens GN=NID1 PE=1 SV=3 (Range: 52-175)
PDB0516 1-261 -104.000 31  1j6o_A mol:protein length:268 TatD-related deoxyribonuclease
PfamA30U 4-260 -93.900 29  PF01026.19; Y454_HAEIN/4-256; TatD related DNase
SCOP206 3-261 -105.000 31  d1j6oa1 c.1.9.12 (A:0-255) Hypothetical protein TM0667 {Thermotoga maritima [TaxId: 2336]}
VFDB 3-260 -7.600 10  VFG001351(gi:22537332) (cpsB) CpsB phosphatase [Capsule (VF0274)] [Streptococcus agalactiae 2603V/R]
10 gi|12044860|ref|NP_072670.1| DNA primase-related protein (MG_010) [Mycoplasma genitalium G37] 218 COG0516 2-217 -60.700 17  [L] COG0358 DNA primase (bacterial type)
H.sapiens 25-216 -29.700 16  sp|Q96RR1|PEO1_HUMAN(removed signalp:1-19) Twinkle protein, mitochondrial OS=Homo sapiens GN=PEO1 PE=1 SV=1 (Range: 151-450)
HGM_OVER 36-162 -4.200 13  PB012991 Q2RHT0_MOOTA/1-175 PB012991; Pfam-B_12991;
JCSG0516 5-217 -64.300 19  TM1452 TM1452 283310 Selected-2001-10-12
NEW_HUMAN_DOMAINS 115-165 -4.470 25  sp|Q9Y2V7|COG6_HUMAN Conserved oligomeric Golgi complex subunit 6 OS=Homo sapiens GN=COG6 PE=2 SV=2 (Range: 1-54)
PDB0516 1-215 -77.900 18  4e2k_A mol:protein length:329 DNA primase
PfamA30U 1-106 -39.200 11  PF08275.9; Q8F416_LEPIN/119-248; DNA primase catalytic core, N-terminal domain
114-201 -41.900 22  PF13155.4; Q8EPY5_OCEIH/263-348; Toprim-like
SCOP206 2-217 -66.400 18  d1dd9a_ e.13.1.1 (A:) DNA primase DnaG catalytic core {Escherichia coli [TaxId: 562]}
VFDB 60-217 -8.990 13  VFG045552(gi:52842203) (lpg1986) Dot/Icm type IV secretion system effector [Dot/Icm (VF0156)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
11 gi|12044861|ref|NP_072671.1| hypothetical protein (MG_011) [Mycoplasma genitalium G37] 287 COG0516 1-282 -29.700 12  [HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)
H.sapiens 8-285 -72.800 15  sp|Q8IXN7|RIMKA_HUMAN Ribosomal protein S6 modification-like protein A OS=Homo sapiens GN=RIMKLA PE=2 SV=2
HGM_OVER 181-285 -3.270 PB004996 Q5NNS6_ZYMMO/1-150 PB004996; Pfam-B_4996;
JCSG0516 9-287 -69.700 16  PU9803J YP_001095162.1 381332 Crystal|NMR-2007-12-14
NEW_HUMAN_DOMAINS 79-196 -6.460 sp|Q66K74|MAP1S_HUMAN Microtubule-associated protein 1S OS=Homo sapiens GN=MAP1S PE=1 SV=2 (Range: 328-458)
PDB0516 9-279 -76.000 17  3vpb_A mol:protein length:282 Putative acetylornithine deacetylase
PfamA30U 5-275 -32.800 12  PF05770.9; ITPK1_ORYSJ/37-341; Inositol 1, 3, 4-trisphosphate 5/6-kinase
94-273 -65.200 19  PF08443.9; RIMK_HAEIN/105-293; RimK-like ATP-grasp domain
SCOP206 13-96 -17.300 14  d3vpda1 c.30.1.0 (A:1-88) automated matches {Thermus thermophilus [TaxId: 274]}
97-278 -62.800 17  d3vpda2 d.142.1.7 (A:89-281) automated matches {Thermus thermophilus [TaxId: 274]}
VFDB 178-279 -5.790 10  VFG002249(gi:49476210) (trwN) Trw type IV secretion sysmtem trwN protein [Trw type IV secretion system (VF0372)] [Bartonella henselae str. Houston-1]
12 gi|12044862|ref|NP_072672.1| alpha-L-glutamate ligase (MG_012) [Mycoplasma genitalium G37] 287 COG0516 1-287 -29.000 21  [HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)
H.sapiens 2-287 -76.500 22  sp|Q8IXN7|RIMKA_HUMAN Ribosomal protein S6 modification-like protein A OS=Homo sapiens GN=RIMKLA PE=2 SV=2
HGM_OVER 154-287 -4.840 PB015954 Q6WBB3_BIFBR/1-225 PB015954; Pfam-B_15954;
JCSG0516 8-287 -73.900 18  PU9803C NP_873685.1 381379 Purified-2007-10-11
NEW_HUMAN_DOMAINS 188-259 -4.470 12  sp|Q96NE9|FRMD6_HUMAN FERM domain-containing protein 6 OS=Homo sapiens GN=FRMD6 PE=1 SV=1 (Range: 547-622)
PDB0516 8-287 -75.500 23  4iwx_A mol:protein length:320 Ribosomal protein S6 modification protein
PfamA30U 6-287 -28.700 10  PF05770.9; ITPK1_ORYSJ/37-341; Inositol 1, 3, 4-trisphosphate 5/6-kinase
90-287 -65.800 23  PF08443.9; RIMK_HAEIN/105-293; RimK-like ATP-grasp domain
SCOP206 13-92 -17.000 15  d3vpda1 c.30.1.0 (A:1-88) automated matches {Thermus thermophilus [TaxId: 274]}
93-287 -58.700 21  d3vpda2 d.142.1.7 (A:89-281) automated matches {Thermus thermophilus [TaxId: 274]}
VFDB 155-275 -5.260 14  VFG000007(gi:33592928) (fimB) chaperone protein [Fimbriae (VF0031)] [Bordetella pertussis Tohama I]
13 gi|108885077|ref|NP_072673.2| methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase (MG_013) [Mycoplasma genitalium G37] 273 COG0516 2-266 -113.000 28  [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase
H.sapiens 2-272 -108.000 30  sp|P13995|MTDC_HUMAN(removed signalp:1-20) Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Homo sapiens GN=MTHFD2 PE=1 SV=2
HGM_OVER 2-202 -3.570 PB005346 A0R807_PELPD/1-258 PB005346; Pfam-B_5346;
JCSG0516 1-267 -105.000 28  TM1767 TM1767 283621 Purified-2001-12-11
NEW_HUMAN_DOMAINS 225-272 -15.900 12  sp|Q6UB35|C1TM_HUMAN Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Homo sapiens GN=MTHFD1L PE=1 SV=1 (Range: 298-355)
PDB0516 2-267 -117.000 30  3p2o_A mol:protein length:285 Bifunctional protein folD
PfamA30U 2-111 -55.800 31  PF00763.21; FOLD_BACSK/6-121; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
114-264 -77.200 23  PF02882.17; FOLD1_ARATH/184-349; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
SCOP206 2-112 -56.600 35  d4b4ua1 c.58.1.0 (A:1-121) automated matches {Acinetobacter baumannii [TaxId: 575584]}
113-267 -77.900 31  d4b4ua2 c.2.1.0 (A:122-282) automated matches {Acinetobacter baumannii [TaxId: 575584]}
VFDB 1-267 -5.100 VFG000163(gi:15597594) (fpvA) ferripyoverdine receptor FpvA [Pyoverdine (VF0094)] [Pseudomonas aeruginosa PAO1]
14 gi|12044864|ref|NP_072674.1|(removed signalp:1-25) ABC transporter, ATP-binding/permease protein (MG_014) [Mycoplasma genitalium G37] 598 COG0516 2-590 -91.500 23  [V] COG1132 ABC-type multidrug transport system, ATPase and permease components
H.sapiens 77-377 -41.700 17  sp|Q03518|TAP1_HUMAN Antigen peptide transporter 1 OS=Homo sapiens GN=TAP1 PE=1 SV=2 (Range: 301-600)
164-477 -56.000 17  sp|Q9NUT2|ABCB8_HUMAN ATP-binding cassette sub-family B member 8, mitochondrial OS=Homo sapiens GN=ABCB8 PE=1 SV=3 (Range: 301-600)
194-510 -67.500 25  sp|Q03519|TAP2_HUMAN(removed signalp:1-28) Antigen peptide transporter 2 OS=Homo sapiens GN=TAP2 PE=1 SV=1 (Range: 301-600)
312-596 -73.200 33  sp|Q9NP78|ABCB9_HUMAN(removed signalp:1-23) ATP-binding cassette sub-family B member 9 OS=Homo sapiens GN=ABCB9 PE=1 SV=1 (Range: 451-743)
HGM_OVER 377-591 -4.590 10  HGC00374 gi|162831834|dbj|BABA01012875.1|1.0 TMP00304;
JCSG0516 1-596 -142.000 30  TM0287 TM0287 282163 Purified-2001-02-27
NEW_HUMAN_DOMAINS 291-385 -4.100 sp|Q6P2S7|GNN_HUMAN Tetratricopeptide repeat protein GNN OS=Homo sapiens GN=GNN PE=2 SV=3 (Range: 217-335)
PDB0516 1-596 -142.000 30  4q4j_A mol:protein length:587 ABC transporter
PfamA30U 1-265 -13.500 11  PF13748.4; G8PNQ8_PSEUV/20-254; ABC transporter transmembrane region
358-517 -27.700 22  PF00005.25; YTFR_ECOLI/25-174; ABC transporter
SCOP206 2-324 -37.600 16  d4a82a1 f.37.1.1 (A:1-323) Putative multidrug export ATP-binding/permease protein SAV1866 {Human (Homo sapiens) [TaxId: 9606]}
362-589 -94.400 37  d4q7ka_ c.37.1.0 (A:) automated matches {Thermotoga maritima [TaxId: 243274]}
VFDB 2-590 -92.200 27  VFG013248(gi:16272034) (msbA) lipid transporter ATP-binding/permease [LOS (CVF494)] [Haemophilus influenzae Rd KW20]
15 gi|12044865|ref|NP_072675.1|(removed signalp:1-25) ABC transporter, ATP-binding/permease protein (MG_015) [Mycoplasma genitalium G37] 564 COG0516 4-564 -92.600 27  [U] KOG0058 Peptide exporter, ABC superfamily
37-564 -106.000 30  [V] COG1132 ABC-type multidrug transport system, ATPase and permease components
H.sapiens 3-306 -38.700 13  sp|Q9NUT2|ABCB8_HUMAN ATP-binding cassette sub-family B member 8, mitochondrial OS=Homo sapiens GN=ABCB8 PE=1 SV=3 (Range: 151-450)
58-362 -48.600 18  sp|Q03518|TAP1_HUMAN Antigen peptide transporter 1 OS=Homo sapiens GN=TAP1 PE=1 SV=2 (Range: 301-600)
140-444 -60.100 23  sp|Q9NP78|ABCB9_HUMAN(removed signalp:1-23) ATP-binding cassette sub-family B member 9 OS=Homo sapiens GN=ABCB9 PE=1 SV=1 (Range: 301-600)
181-485 -66.900 25  sp|Q03519|TAP2_HUMAN(removed signalp:1-28) Antigen peptide transporter 2 OS=Homo sapiens GN=TAP2 PE=1 SV=1 (Range: 301-600)
212-511 -68.800 27  sp|Q03518|TAP1_HUMAN Antigen peptide transporter 1 OS=Homo sapiens GN=TAP1 PE=1 SV=2 (Range: 451-750)
297-562 -80.100 39  sp|Q9NP78|ABCB9_HUMAN(removed signalp:1-23) ATP-binding cassette sub-family B member 9 OS=Homo sapiens GN=ABCB9 PE=1 SV=1 (Range: 451-743)
HGM_OVER 427-543 -4.110 14  PB202086 Q8G498_BIFLO/2-200 PB202086; Pfam-B_202086;
JCSG0516 3-564 -157.000 34  TM0288 TM0288 282164 Purified-2001-02-27
NEW_HUMAN_DOMAINS 462-551 -4.510 13  sp|Q9UJX4|APC5_HUMAN Anaphase-promoting complex subunit 5 OS=Homo sapiens GN=ANAPC5 PE=1 SV=2 (Range: 655-755)
PDB0516 3-564 -157.000 34  3qf4_B mol:protein length:598 Uncharacterized ABC transporter ATP-binding p
PfamA30U 3-251 -27.000 PF13748.4; G8PNQ8_PSEUV/20-254; ABC transporter transmembrane region
343-492 -27.100 28  PF00005.25; YTFR_ECOLI/25-174; ABC transporter
353-536 -11.500 17  PF00625.19; KGUA_ECOLI/4-186; Guanylate kinase
SCOP206 3-311 -58.700 15  d4a82a1 f.37.1.1 (A:1-323) Putative multidrug export ATP-binding/permease protein SAV1866 {Human (Homo sapiens) [TaxId: 9606]}
327-564 -83.000 36  d1mv5a_ c.37.1.12 (A:) Multidrug resistance ABC transporter LmrA, C-terminal domain {Lactococcus lactis [TaxId: 1358]}
VFDB 3-564 -91.800 19  VFG002176(gi:21693305) (cylB) ABC-type transporter [Cytolysin (VF0356)] [Enterococcus faecalis str. MMH594]
37-563 -103.000 31  VFG013248(gi:16272034) (msbA) lipid transporter ATP-binding/permease [LOS (CVF494)] [Haemophilus influenzae Rd KW20]
16 gi|108885078|ref|NP_072678.2| SNF2 family helicase putative (MG_018) [Mycoplasma genitalium G37] (Range: 1-500) 500 COG0516 1-100 -28.000 19  [S] COG4715 Uncharacterized conserved protein
1-500 -21.100 11  [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family
H.sapiens 1-191 -32.000 11  sp|Q9P217|ZSWM5_HUMAN Zinc finger SWIM domain-containing protein 5 OS=Homo sapiens GN=ZSWIM5 PE=2 SV=2 (Range: 151-450)
HGM_OVER 313-499 -5.940 10  PB023890 Q7MUU3_PORGI/1-263 PB023890; Pfam-B_23890;
JCSG0516 430-498 -6.290 13  GS13881A YP_001300746.1 384506 Purified-2008-05-17
NEW_HUMAN_DOMAINS 1-134 -34.200 12  sp|Q9H7M6|ZSWM4_HUMAN Zinc finger SWIM domain-containing protein 4 OS=Homo sapiens GN=ZSWIM4 PE=2 SV=3 (Range: 33-228)
PDB0516 277-500 -7.120 11  2fgt_A mol:protein length:417 Two-component system yycF/yycG regulatory pro
PfamA30U 46-85 -12.000 42  PF04434.15; Y020_MYCPN/46-86; SWIM zinc finger
217-500 -41.700 13  PF08455.8; R4KHE0_9FIRM/244-621; Bacterial SNF2 helicase associated
SCOP206 11-75 -6.360 12  d1l3wa5 b.1.6.1 (A:434-540) C-cadherin ectodomain {African clawed frog (Xenopus laevis) [TaxId: 8355]}
VFDB 418-499 -5.570 13  VFG000392(gi:16082730) (yscP) type III secretion system needle length regulator [TTSS (VF0140)] [Yersinia pestis CO92]
17 gi|108885078|ref|NP_072678.2| SNF2 family helicase putative (MG_018) [Mycoplasma genitalium G37] (Range: 251-750) 500 COG0516 38-500 -73.400 22  [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family
H.sapiens 102-400 -48.200 16  sp|O14981|BTAF1_HUMAN TATA-binding protein-associated factor 172 OS=Homo sapiens GN=BTAF1 PE=1 SV=2 (Range: 1051-1350)
205-469 -49.300 20  sp|Q5T890|RAD26_HUMAN Putative DNA repair and recombination protein RAD26-like OS=Homo sapiens GN=RAD26L PE=2 SV=1 (Range: 1-300)
240-500 -62.900 26  sp|Q2NKX8|ERC6L_HUMAN DNA excision repair protein ERCC-6-like OS=Homo sapiens GN=ERCC6L PE=1 SV=1 (Range: 1-300)
280-500 -67.000 30  sp|O14981|BTAF1_HUMAN TATA-binding protein-associated factor 172 OS=Homo sapiens GN=BTAF1 PE=1 SV=2 (Range: 1201-1500)
HGM_OVER 324-500 -3.750 13  PB028090 gi|167758043|ref|ZP_02430170.1| hypothetical protein CLOSCI_00381 [Clostridium scindens ATCC 35704]gi|167663940|gb|EDS08070.1| hypothetical protein CLOSCI_00381 [Clostridium scindens ATCC 35704]
JCSG0516 125-500 -38.100 12  FR15026A NP_905257.1 392915 Crystal|NMR-2009-05-13
298-500 -43.800 29  RF3866A.HELLS BC100394 421236 Purified-2011-02-13
NEW_HUMAN_DOMAINS 338-498 -4.990 13  sp|Q8N9H9|CA127_HUMAN Uncharacterized protein C1orf127 OS=Homo sapiens GN=C1orf127 PE=2 SV=2 (Range: 1-200)
PDB0516 119-499 -10.300 10  4a2w_A mol:protein length:936 RETINOIC ACID INDUCIBLE PROTEIN I
204-500 -21.600 15  4s20_K mol:protein length:974 RNA polymerase-associated protein RapA
317-500 -46.000 41  1z63_A mol:protein length:500 Helicase of the snf2/rad54 family
PfamA30U 3-321 -36.500 13  PF08455.8; R4KHE0_9FIRM/244-621; Bacterial SNF2 helicase associated
331-500 -38.500 30  PF00176.21; RAD54_SCHPO/267-575; SNF2 family N-terminal domain
SCOP206 211-491 -17.500 13  d1rifa_ c.37.1.23 (A:) DNA helicase UvsW {Bacteriophage T4 [TaxId: 10665]}
316-500 -65.300 41  d1z63a1 c.37.1.19 (A:432-661) Helicase of the SNF2/Rad54 hamily {Sulfolobus solfataricus [TaxId: 2287]}
VFDB 318-497 -6.230 15  VFG002395(gi:15608922) (eccCb5) ESX-5 type VII secretion system FtsK/SpoIIIE family protein EccCb5 [ESX-5 (VF0402)] [Mycobacterium tuberculosis H37Rv]
18 gi|108885078|ref|NP_072678.2| SNF2 family helicase putative (MG_018) [Mycoplasma genitalium G37] (Range: 501-1000) 500 COG0516 1-500 -111.000 33  [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family
H.sapiens 1-264 -64.400 27  sp|Q2NKX8|ERC6L_HUMAN DNA excision repair protein ERCC-6-like OS=Homo sapiens GN=ERCC6L PE=1 SV=1 (Range: 1-300)
36-283 -74.000 31  sp|O14981|BTAF1_HUMAN TATA-binding protein-associated factor 172 OS=Homo sapiens GN=BTAF1 PE=1 SV=2 (Range: 1201-1500)
196-491 -84.900 24  sp|Q5FWF4|ZRAB3_HUMAN Zinc finger Ran-binding domain-containing protein 3 OS=Homo sapiens GN=ZRANB3 PE=2 SV=2 (Range: 151-450)
HGM_OVER 341-494 -4.120 14  PB007843 JCVI_PEP_1096682172521 /source_dna_id=JCVI_ORF_1096682172520 /offset=0 /translation_table=11 /length=152 /full_length=152
JCSG0516 48-500 -84.500 29  RF3866A.HELLS BC100394 421236 Purified-2011-02-13
NEW_HUMAN_DOMAINS 202-281 -6.500 15  sp|P57076|CU059_HUMAN Uncharacterized protein C21orf59 OS=Homo sapiens GN=C21orf59 PE=1 SV=1 (Range: 101-187)
PDB0516 67-499 -101.000 37  1z63_A mol:protein length:500 Helicase of the snf2/rad54 family
PfamA30U 81-354 -56.300 29  PF00176.21; RAD54_SCHPO/267-575; SNF2 family N-terminal domain
297-500 -23.100 10  PF11496.6; Q6FSK5_CANGA/26-299; Class II histone deacetylase complex subunits 2 and 3
SCOP206 66-296 -81.600 39  d1z63a1 c.37.1.19 (A:432-661) Helicase of the SNF2/Rad54 hamily {Sulfolobus solfataricus [TaxId: 2287]}
298-499 -61.300 35  d1z5za1 c.37.1.19 (A:663-906) Helicase of the SNF2/Rad54 hamily {Sulfolobus solfataricus [TaxId: 2287]}
VFDB 82-412 -4.880 VFG001393(gi:15608485) (mbtM) Probable fatty acyl-AMP ligase MbtM [FadD33 (VF0308)] [Mycobacterium tuberculosis H37Rv]
19 gi|108885078|ref|NP_072678.2| SNF2 family helicase putative (MG_018) [Mycoplasma genitalium G37] (Range: 751-1031) 281 COG0516 1-281 -76.000 34  [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family
H.sapiens 1-241 -78.200 22  sp|Q5FWF4|ZRAB3_HUMAN Zinc finger Ran-binding domain-containing protein 3 OS=Homo sapiens GN=ZRANB3 PE=2 SV=2 (Range: 151-450)
2-281 -78.000 20  sp|Q9NZC9|SMAL1_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 OS=Homo sapiens GN=SMARCAL1 PE=1 SV=1 (Range: 601-900)
HGM_OVER 91-266 -3.970 12  PB007843 JCVI_PEP_1096682172521 /source_dna_id=JCVI_ORF_1096682172520 /offset=0 /translation_table=11 /length=152 /full_length=152
JCSG0516 1-281 -54.700 28  RF3866A.HELLS BC100394 421236 Purified-2011-02-13
NEW_HUMAN_DOMAINS 169-279 -5.280 10  sp|Q9NR09|BIRC6_HUMAN Baculoviral IAP repeat-containing protein 6 OS=Homo sapiens GN=BIRC6 PE=1 SV=2 (Range: 2039-2203)
PDB0516 27-281 -83.400 33  1z5z_A mol:protein length:271 Helicase of the snf2/rad54 family
PfamA30U 1-104 -16.400 29  PF00176.21; RAD54_SCHPO/267-575; SNF2 family N-terminal domain
47-281 -28.900 10  PF11496.6; Q6FSK5_CANGA/26-299; Class II histone deacetylase complex subunits 2 and 3
SCOP206 1-46 -9.970 37  d1z63a1 c.37.1.19 (A:432-661) Helicase of the SNF2/Rad54 hamily {Sulfolobus solfataricus [TaxId: 2287]}
48-281 -80.100 35  d1z5za1 c.37.1.19 (A:663-906) Helicase of the SNF2/Rad54 hamily {Sulfolobus solfataricus [TaxId: 2287]}
VFDB 87-275 -5.770 VFG002520(gi:53720902) (flhG) flagellar biosynthesis protein FlhG [Flagella (VF0430)] [Burkholderia pseudomallei K96243]
20 gi|12044869|ref|NP_072679.1| chaperone protein DnaJ (MG_019) [Mycoplasma genitalium G37] 389 COG0516 3-388 -119.000 32  [O] COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain
H.sapiens 3-389 -113.000 26  sp|Q96EY1|DNJA3_HUMAN(removed signalp:1-21) DnaJ homolog subfamily A member 3, mitochondrial OS=Homo sapiens GN=DNAJA3 PE=1 SV=2
HGM_OVER 1-78 -3.600 15  PB009671 Q5LCM2_BACFN/1-111 PB009671; Pfam-B_9671;
JCSG0516 1-378 -136.000 32  TM0849 TM0849 282719 Selected-2001-10-12
NEW_HUMAN_DOMAINS 137-225 -8.450 15  sp|Q6ZRI0|OTOG_HUMAN Otogelin OS=Homo sapiens GN=OTOG PE=2 SV=3 (Range: 2441-2829)
PDB0516 1-375 -85.000 23  3lz8_A mol:protein length:329 Putative chaperone DnaJ
PfamA30U 7-74 -38.800 52  PF00226.29; Q22028_CAEEL/17-79; DnaJ domain
137-355 -85.200 28  PF01556.16; T0NBZ6_9EURY/129-343; DnaJ C terminal domain
SCOP206 1-87 -45.800 26  d2yuaa1 a.2.3.0 (A:8-93) automated matches {Human (Homo sapiens) [TaxId: 9606]}
151-234 -36.000 31  d1exka_ g.54.1.1 (A:) Cysteine-rich domain of the chaperone protein DnaJ {Escherichia coli [TaxId: 562]}
203-277 -11.700 13  d1nlta1 b.4.1.1 (A:110-138,A:213-257) Mitochondrial protein import protein mas5 (Hsp40, Ydj1), C-terminal domain {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
278-369 -21.300 25  d3agxa2 b.4.1.0 (A:246-340) automated matches {Human (Homo sapiens) [TaxId: 9606]}
VFDB 10-197 -5.720 10  VFG002358(gi:123442806) (flhC) flagellar biosynthesis transcription activator FlhC [Flagella (VF0394)] [Yersinia enterocolitica subsp. enterocolitica 8081]


FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Friedberg I, Godzik A. Functional differentiation of proteins: implications for structural genomics. Structure. 2007 Apr;15(4):405-15.